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https://www.readbyqxmd.com/read/29144549/zuclopenthixol-dihydrochloride-for-schizophrenia
#1
REVIEW
Edward J Bryan, Marie Ann Purcell, Ajit Kumar
BACKGROUND: Oral zuclopenthixol dihydrochloride (Clopixol) is an anti-psychotic treatment for people with psychotic symptoms, especially those with schizophrenia. It is associated with neuroleptic malignant syndrome, a prolongation of the QTc interval, extra-pyramidal reactions, venous thromboembolism and may modify insulin and glucose responses. OBJECTIVES: To determine the effects of zuclopenthixol dihydrochloride for treatment of schizophrenia. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Trials Register (latest search 09 June 2015)...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29128195/-what-support-of-young-presenting-a-first-psychotic-episode-when-schooling-is-being-challenged
#2
M-N Vacheron, H Veyrat-Masson, E Wehbe
Psychiatric disorders (more specifically mood disorders and psychosis) represent the 1st cause of disability among young people. Unemployment rate between 75 to 95% for the person with schizophrenia. It is correlated to poor social integration and bad economic status, worse symptomatology loss of autonomy as well as global bad functioning. It is responsible of more than half of the overall cost of psychosis. The onset of most of psychiatric disorders occur between the age of 25 and 35 years old, a critical time in young adult life when they should build their professional as well as social future...
November 8, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29125018/the-glasgow-antipsychotic-side-effects-scale-for-clozapine-in-inpatients-and-outpatients-with-schizophrenia-or-schizoaffective-disorder
#3
Dragana Ignjatović Ristić, Dan Cohen, Andrea Obradović, Katarina Nikić-Đuričić, Marija Drašković, Darko Hinić
BACKGROUND: The inconsistency in clinician and patient ratings of clozapine-induced side effects underscore the need to supplement clinician-based estimates of side effects with patient-reported ones. AIMS: The main aims of the study are validation of the Glasgow antipsychotic side-effects scale for clozapine (GASS-C) in Serbian inpatients/outpatients with schizophrenia or schizo-affective disorder and recommendations for its future use, based on common and rare clozapine-associated side-effects...
November 10, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29120842/do-cognitive-deficits-predict-negative-emotionality-and-aggression-in-schizophrenia
#4
Anthony O Ahmed, Jenae Richardson, Alex Buckner, Sabrina Romanoff, Michelle Feder, Njideka Oragunye, Andriana Ilnicki, Ishrat Bhat, Matthew J Hoptman, Jean-Pierre Lindenmayer
Schizophrenia is associated with an elevated risk of aggression. Cognitive deficits have been associated with inpatient aggression and future violence. The relationship between cognitive deficits and violent behavior has however been inconsistent across studies. In addition, studies have failed to inform how cognitive deficits may contribute to aggression in schizophrenia. The current study examined the association of cognitive deficits with schizophrenia-related aggression and violent offending. It also explored the putative mediating role of negative emotionality on the impact of cognitive deficits on aggression...
November 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29117910/increased-resting-state-global-functional-connectivity-density-of-default-mode-network-in-schizophrenia-subjects-treated-with-electroconvulsive-therapy
#5
Huan Huang, Yuchao Jiang, Mengqing Xia, Yingying Tang, Tianhong Zhang, Huiru Cui, Junjie Wang, Yu Li, Lihua Xu, Adrian Curtin, Jianhua Sheng, Yuping Jia, Dezhong Yao, Chunbo Li, Cheng Luo, Jijun Wang
Modified electroconvulsive therapy (MECT) has been widely applied to help treat schizophrenia patients who are treatment-resistant to pharmaceutical therapy. Although the technique is increasingly prevalent, the underlying neural mechanisms have not been well clarified. We conducted a longitudinal study to investigate the alteration of global functional connectivity density (gFCD) in schizophrenia patients undergoing MECT using resting state fMRI (functional magnetic resonance imaging). Two groups of schizophrenia inpatients were recruited...
November 6, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29109559/curriculum-in-psychiatry-and-neurology-for-pharmacy-programs
#6
Julie A Dopheide, Jolene R Bostwick, Lisa W Goldstone, Kelan Thomas, Ruth Nemire, Kelly N Gable, Marshall Cates, Joshua Caballero, Tawny Smith, Jacquelyn Bainbridge
Objective. To describe pharmacy curricula in psychiatry and neurology and to report on neuropsychiatric pharmacy specialists' views on optimal curriculum. Methods. Design and administer one electronic survey to accredited pharmacy programs asking them to report information on curricula in psychiatry and neurology for the 2014-2015 academic year. Design and administer a separate electronic survey to board certified pharmacists with an academic affiliation who are members of the College of Psychiatric and Neurologic Pharmacists (CPNP) asking about their teaching activities and their opinion on optimal curricula...
September 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29097970/the-construct-of-the-schizophrenia-quality-of-life-scale-revision-4-for-the-population-of-taiwan
#7
Chia-Ting Su, Ai-Lun Yang, Chung-Ying Lin
This study examines the factor structure of the Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4) for inpatients with schizophrenia in a psychiatric hospital in southern Taiwan. All the participants (n = 100) filled out the SQLS-R4, Mini Mental Status Examination (MMSE), and Brief Psychiatric Rating Scale (BPRS) under the supervision of one experienced occupational therapist. Using confirmatory factor analysis, we first determined that a 29-item model was more satisfactory than the original 33-item model based on the findings of better fit indices for the 29-item model...
2017: Occupational Therapy International
https://www.readbyqxmd.com/read/29095057/high-inpatient-utilization-among-veterans-health-administration-patients-with-substance-use-disorders-and-co-occurring-mental-health-conditions
#8
Janelle M Painter, Carol A Malte, Anna D Rubinsky, Timothy R Campellone, Amanda K Gilmore, John S Baer, Eric J Hawkins
BACKGROUND: Substance-use disorders (SUDs) are common and costly conditions. Understanding high inpatient utilization (HIU) among patients with SUD can inform the development of treatment approaches designed to reduce healthcare expenditures and improve service quality. OBJECTIVES: To examine the prevalence, type, and predictors of HIU among patients with SUD and co-occurring mental health conditions. METHODS: Service utilization and demographic and clinical variables were extracted from a national sample of Veterans Health Administration (VA) patients with SUD-only [n = 148,960 (98...
November 2, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/29081923/healthcare-resource-use-in-schizophrenia-eurosc-findings
#9
A Millier, M Horváth, F Ma, K Kóczián, A Götze, M Toumi
Background: It is unclear if the burden associated with schizophrenia is affected by the type and severity of patient's symptoms. Objective: This study aims to quantify healthcare resource use associated with different profiles of schizophrenia symptoms. Study design: Post-hoc analysis of data from a naturalistic follow-up study. Setting: Secondary psychiatric services in France, Germany and the UK. Patients: EuroSC cohort:, representative sample of 1,208 schizophrenia patients Main outcome measure: We classified patients into eight health states, according to the Lenert classification (HS1-HS8), and estimated 6-month healthcare resource use (outpatient and day clinic visits, and hospitalisations) across the health states...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/29079989/osteopenia-and-the-physical-function-in-japanese-patients-with-schizophrenia
#10
Satoru Uchida, Tsuyoshi Ichinose, Yoichi Iizuka, Koichi Okamura, Hitoshi Shitara, Manabu Yamazaki, Kenji Takagishi, Haku Iizuka
We evaluated the state of osteopenia and the physical function in 121 schizophrenic patients. These factors were worse in the inpatient group than in the outpatient group. The age, sex, body mass index (BMI), and physical function were correlated to the state of osteopenia. Physicians should consider the risk of osteopenia in elderly female psychiatric patients with low BMI. PURPOSE: Information about the actual state of osteopenia in patients with schizophrenia is limited. In the present study, we evaluated the factors related to osteopenia and patient's physical function and compared these factors between inpatients and outpatients...
October 27, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29061438/symptom-profile-of-catatonia-in-children-and-adolescents-admitted-to-psychiatry-inpatient-unit
#11
Sandeep Grover, Nidhi Chauhan, Akhilesh Sharma, Subho Chakrabarti, Ajit Avasthi
AIM: To study the symptom profile of catatonia in children and adolescents. METHODOLOGY: Treatment records of all the inpatients aged (≤19 years) were reviewed for the period January 2005 to January 2017. Patients with catatonia (diagnosed as having at least two symptoms as per the Bush Francis Catatonia Rating scale) were included. RESULTS: During the study period, data was available for 52 children and adolescent. The mean age of the sample was 16...
October 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29056492/prevalence-risk-factors-and-clinical-characteristics-of-osteoporosis-in-chinese-inpatients-with-schizophrenia
#12
Jingyi Cui, Huaqing Liu, Jing Shao, Dong-Mei Xu, Yi Wang, Zheng Fei, Jiyu Wei, Wei Lu, Chun-Rong Wang, Rui He, Yangya Tan, Yi Fan, Yuping Ning, Ryan M Cassidy, Jair C Soares, Xingbing Huang, Xiang Yang Zhang
Patients with schizophrenia have a high prevalence of developing osteoporosis and osteoporosis-related fractures. We examined the prevalence of osteoporosis and its clinical correlates in Chinese patients with schizophrenia, which is not well-studied. A total of 199 inpatients (males/females=132/67; average age: 54.5±11.1years) and 107 healthy controls (males/females=22/85; average age: 41.7±11.9years) were recruited. Bone mineral density (BMD) was measured by ultrasonography of the calcaneus. The prevalence of osteoporosis and low BMD (osteoporosis and osteopenia) was 23...
October 19, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29054486/prevalence-of-underweight-in-patients-with-schizophrenia-a-meta-analysis
#13
Norio Sugawara, Kazushi Maruo, Takuro Sugai, Yutaro Suzuki, Yuji Ozeki, Kazutaka Shimoda, Toshiyuki Someya, Norio Yasui-Furukori
AIMS: Although the relationship between body mass index and all-cause mortality is U-shaped, underweight has received comparatively less attention than obesity. There is only limited evidence to date regarding underweight among patients with schizophrenia. This is the first meta-analysis to address the prevalence of underweight in these patients. METHODS: We conducted database searches (PubMed, PsycINFO) to identify studies examining underweight in patients with schizophrenia...
October 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/29053485/the-effects-of-electroconvulsive-therapy-augmentation-of-antipsychotic-treatment-on-cognitive-functions-in-patients-with-treatment-resistant-schizophrenia
#14
Bjanka Vuksan Ćusa, Nataša Klepac, Nenad Jakšić, Zoran Bradaš, Marija Božičević, Natalia Palac, Marina Šagud
OBJECTIVES: Treatment-resistant schizophrenia (TRS) continues to be a challenge in modern psychiatry. Most of these patients have severe neurocognitive deficits. Electroconvulsive therapy (ECT) has proved effective and safe in the treatment of TRS, but because of potential neurocognitive adverse effects, it is associated with many controversies. The aim of this prospective, open study was to evaluate the effects of ECT augmentation of antipsychotics on cognitive functions in patients with TRS...
October 19, 2017: Journal of ECT
https://www.readbyqxmd.com/read/29049078/hearts-and-minds-real-life-cardiotoxicity-with-clozapine-in-psychosis
#15
George Joy, Eromona Whiskey, Mark Bolstridge, Alejandro Porras-Segovia, Theresa A McDonagh, Carla M Plymen, Sukhi S Shergill
BACKGROUND: Schizophrenia has a 1% prevalence in the population; 30% of these patients are treatment refractory. Clozapine is the only drug licensed to treat treatment refractory psychosis, but concerns about potential adverse effects result in only a proportion of eligible patients being treated. Although a well-documented neutropenia risk is mitigated by routine blood testing, cardiac toxicity is a commonly cited reason to discontinue clozapine treatment. However, there is little data on the real-life cardiac outcomes in those receiving clozapine treatment...
October 19, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29036206/risk-characterization-of-hospitalizations-for-mental-illness-and-or-behavioral-disorders-with-concurrent-heat-related-illness
#16
Michael T Schmeltz, Janet L Gamble
BACKGROUND: Many studies have found significant associations between high ambient temperatures and increases in heat-related morbidity and mortality. Several studies have demonstrated that increases in heat-related hospitalizations are elevated among individuals with diagnosed mental illnesses and/or behavioral disorders (MBD). However, there are a limited number of studies regarding risk factors associated with specific mental illnesses that contribute, at least in part, to heat-related illnesses (HRI) in the United States...
2017: PloS One
https://www.readbyqxmd.com/read/29029972/development-of-indicators-for-a-nationwide-cross-sectoral-quality-assurance-procedure-for-mental-health-care-of-patients-with-schizophrenia-schizotypal-and-delusional-disorders-in-germany
#17
Constance Stegbauer, Gerald Willms, Katja Kleine-Budde, Anke Bramesfeld, Carina Stammann, Joachim Szecsenyi
PURPOSE: This paper describes the development of quality indicators for an external statutory and cross-sectoral quality assurance (QA) procedure in the context of the German health care system for adult patients suffering from schizophrenia, schizotypal and delusional disorders (F20-F29). METHODS: Indicators were developed by a modified RAND/UCLA Appropriateness Method with 1) the compilation of an indicator register based on a systematic literature search and analyses of health care claims data, 2) the selection of indicators by an expert panel that rated them for relevance and for feasibility regarding implementation...
October 10, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29023285/predictors-of-electroconvulsive-therapy-use-in-a-large-inpatient-psychiatry-population
#18
Julia Knight, Micaela Jantzi, John Hirdes, Terry Rabinowitz
OBJECTIVE: There is limited research on reliable and clinically useful predictors of electroconvulsive therapy (ECT) use. We aimed to examine factors that predict ECT use in an inpatient psychiatric population. DESIGN: Retrospective analysis of provincial database for inpatient psychiatry. METHODS: This study is a retrospective analysis of a provincial database for inpatient psychiatry. The study includes all psychiatric inpatients 18 years or older in Ontario, Canada, assessed with the Resident Assessment Instrument for Mental Health (RAI-MH) within the first 3 days of admission between 2009 and 2014 (n = 153,023)...
October 12, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28965809/predictors-of-negative-symptoms-in-the-chronic-phase-of-schizophrenia-a-cross-sectional-study
#19
Koichiro Fujimaki, Shigeru Toki, Hidehisa Yamashita, Takahiro Oyamada, Shigeto Yamawaki
This study was designed to investigate the relationship between negative symptoms and key indicators for long-term hospital stays among inpatients with schizophrenia. A further aim was to elucidate the clinical determinants of negative symptoms. The following were used as index factors: age, duration of illness, duration of hospitalization, age at onset, years of education, smoking status, body mass index, concentrations of serum triglycerides, total cholesterol, uric acid, QTc interval duration from electrocardiography, dose equivalents of antipsychotic and anticholinergic agents, neurocognitive function, drug-induced extrapyramidal symptoms, involuntary movements, and psychiatric symptoms...
September 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28965780/drug-related-predictors-of-readmission-for-schizophrenia-among-patients-admitted-to-treatment-for-drug-use-disorders
#20
Kristine Rømer Thomsen, Birgitte Thylstrup, Michael Mulbjerg Pedersen, Mads Uffe Pedersen, Erik Simonsen, Morten Hesse
BACKGROUND: Patients with schizophrenia and comorbid drug use disorders (DUD) have a severe course of illness. Despite strong evidence that drug use can exacerbate psychotic symptoms, we have limited knowledge of how specific drugs may increase risk of schizophrenia readmission in this group. This study aimed to assess drug-related predictors of readmission for schizophrenia among a national cohort of patients with a history of schizophrenia admitted to DUD treatment. METHODS: A record-linkage study was used to assess drug-related factors associated with readmission to mental health treatment for schizophrenia, using a consecutive cohort of 634 patients admitted to DUD treatment between 2000 and 2006 in Danish treatment services and tracked until February 2013 or death, controlling for baseline psychiatric treatment variables...
September 28, 2017: Schizophrenia Research
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