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Agnieszka Antonowicz, Piotr Skrzypczyk, Beata Kępa, Małgorzata Pańczyk-Tomaszewska
: Toxocariasis is a common zoonosis caused by infection with Toxocara canis or cati larvae. Ocular toxocariasis is one of the forms of infestation found in 1/1,000 - 1/10,000 children. Children with idiopathic nephrotic syndrome (INS) are at high risk of infections, also parasitic infestations, which can, in turn, cause relapses of the disease. A CASE REPORT: We present a case of a 6-year-old boy with steroiddependent nephrotic syndrome. The disease started at age of 2, the boy had 9 relapses of INS, and was treated with oral prednisone, levamisole, and cyclophosphamide...
October 19, 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Ricardo da Silva Raposo, Vamilton Alvares Santarém, Yslla Fernanda Fitz Balo Merigueti, Guita Rubinsky-Elefant, Letícia Maria de Lima Cerazo, Ludimilla Pereira, Bianca Pelegi Zampieri, Aristeu Vieira da Silva, Cecília Braga Laposy
Toxocariasis is a geohelminth zoonosis with worldwide distribution, mainly transmitted through the ingestion of embryonated eggs of nematodes of the Toxocara genus. The disease can also be transmitted to humans as a result of eating raw or undercooked meat of paratenic hosts, such as chickens. Here, we standardized an enzyme-linked immunosorbent assay (ELISA) for evaluating experimentally the kinetic and avidity index (AI) of IgY in broiler chickens infected with different doses of Toxocara canis eggs (G1:100; G2: 1000; and G3: 5000; n = 12 per group)...
October 13, 2016: Experimental Parasitology
Myhanh Nguyen, Jay Siak, Soon-Phaik Chee, Vo Quang Hong Diem
PURPOSE: To describe the pattern of uveitis among Vietnamese at two eye hospitals in Southern Vietnam. METHODS: We retrospectively reviewed the charts of 212 consecutive uveitis cases that presented to two eye hospitals in Ho Chi Minh City, Vietnam, from July 2011 to February 2015. The patients were identified from a database maintained by the hospitals. Patients with keratitis, episcleritis, orbital inflammation, post-surgical endophthalmitis, traumatic iritis, and corneal graft rejection were excluded...
October 11, 2016: Ocular Immunology and Inflammation
Gabriela Torres Mattos, Paula Costa Dos Santos, Paula de Lima Telmo, Maria Elisabeth Aires Berne, Carlos James Scaini
Human toxocariasis is a neglected parasitic disease worldwide. Researchers studying this disease use infectious strains of Toxocara for experiments. Health workers are at risk in the course of their daily routine and must adhere to biosafety standards while carrying out the activities. Researchers on biosafety concerning working with these parasites are insufficient. The aim of this study was to determine the rate of seroprevalence of Toxocara species among health-care research laboratory workers (professors, technicians, and students), and to investigate the risk factors of Toxocara infection associated with laboratory practices...
October 3, 2016: American Journal of Tropical Medicine and Hygiene
Rita Leal Sperotto, Frederico Schmitt Kremer, Maria Elisabeth Aires Berne, Luciana F Costa de Avila, Luciano da Silva Pinto, Karina Mariante Monteiro, Karin Silva Caumo, Henrique Bunselmeyer Ferreira, Natália Berne, Sibele Borsuk
Toxocariasis is a neglected disease, and its main etiological agent is the nematode Toxocara canis. Serological diagnosis is performed by an enzyme-linked immunosorbent assay using T. canis excretory and secretory (TES) antigens produced by in vitro cultivation of larvae. Identification of TES proteins can be useful for the development of new diagnostic strategies since few TES components have been described so far. Herein, we report the results obtained by proteomic analysis of TES proteins using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach...
September 13, 2016: Molecular and Biochemical Parasitology
Ana M Olave, Jairo A Mesa, Jorge H Botero, Edwin B Patiño, Gisela M García, Juan F Alzate
INTRODUCTION: Toxocara canis is a pathogenic nematode of canines which can be accidentally transmitted to humans. Although serology is the most important diagnostic tool for this zoonosis, diagnostic kits use crude excretion/secretion antigens, most of them being glycoproteins which are not species-specific and may cross-react with antibodies generated against other parasites.  OBJECTIVES: To produce the rTES-30 recombinant antigen of Toxocara canis and evaluate it in the immunodiagnosis of toxocariasis...
2016: Biomédica: Revista del Instituto Nacional de Salud
Toan Nguyen, Fei Wen Cheong, Jonathan Wee Kent Liew, Yee Ling Lau
BACKGROUND: Despite the global effort against neglected tropical diseases (NTDs), developing countries with middle to low income are still burdened by them. Vietnam has been undergoing substantial economic growth and urbanization, but underprivileged people living in rural and suburban areas are still having little access to public health infrastructure and proper sanitation. Hitherto, limited information is available for seroprevalence and risk factors of several parasitic diseases in Vietnam...
2016: Parasites & Vectors
Felix Lötsch, Markus Obermüller, Johannes Mischlinger, Ghyslain Mombo-Ngoma, Mirjam Groger, Akim Ayola Adegnika, Selidji Todagbe Agnandji, Renate Schneider, Herbert Auer, Michael Ramharter
Toxocara spp. are zoonotic parasites with global distribution infecting humans by incidental ingestions of eggs shed in feces of dogs or cats. High seroprevalences have been reported from several regions of Africa, however data from the Central African region remain limited. Although several clinical entities caused by larvae of Toxocara spp. have been described, the public heath impact of this infection has so far often been neglected. This study was conducted to estimate the prevalence in a rural central African population...
December 2016: Parasitology International
Alparslan Merdin, Emine Ogur, Çiğdem Çiçek Kolak, Fatma Avcı Merdin
Toxocariasis is a parasitic disease caused by the larval stage of Toxocara cati and T. canis, which live in the intestinal system of cats (T. cati) and dogs (T. canis). Infective eggs can enter the gastrointestinal system by the oral route via foods contaminated with feces of dogs or cats or via dirty contaminated hands. The larvae penetrate the small intestine and migrate to visceral organs by systemic circulation. Hypereosinophilia is a common finding in the tissue invasion of parasites. Serological methods are the principle diagnostic methods for toxocariasis...
June 2016: Türkiye Parazitolojii Dergisi
M Zibaei, S M Sadjjadi, S Maraghi
Consuming raw and undercooked meat is known to enhance the risk of human toxocariasis because Toxocara species have a wide range of paratenic hosts, including chickens. The aim of this study was to identify species of Toxocara in naturally infected broiler chickens using molecular approaches. A polymerase chain reaction (PCR) method was used for the differentiation of Toxocara canis and Toxocara cati larvae recovered from tissues and organs, and identified by microscopic observations. Thirty-three 35- to 47-day-old broiler chickens were used for examination of Toxocara larvae...
August 30, 2016: Journal of Helminthology
Mansour Rahimi, Marjan Oustad, Afsaneh Ashrafi
PURPOSE: To determine the clinical features and distribution of uveitis in the pediatric age group at a referral eye care center in Shiraz, South Iran. MATERIALS AND METHODS: All new cases of uveitis in patients 18-year-old or younger referred from January 2007 to December 2013 were enrolled in this study. The patient underwent a complete history of systemic and ocular diseases, comprehensive ophthalmic examination. Patients were classified according to the International Uveitis Study Group definitions...
July 2016: Middle East African Journal of Ophthalmology
Kang Yeun Pak, Sung Who Park, Ik Soo Byon, Ji Eun Lee
BACKGROUND: This report details ocular toxocariasis presenting as bilateral scleritis with suspect retinal granuloma in the nerve fiber layer. CASE PRESENTATION: The patient presented with scleritis, which did not improve with systemic steroid. Intraocular pressure was elevated, and well demarcated hyper-reflective round lesion were noted in both eyes. He had a history of general ache and concurrent onset of ocular symptoms the day after eating raw meat. Systemic work-ups revealed no remarkable abnormalities except antibody for toxocara...
2016: BMC Infectious Diseases
Serap Ural, Behiye Özer, Fazıl Gelal, Derya Dirim Erdoğan, Nurbanu Sezak, Recep Balık, Tuna Demirdal, Metin Korkmaz
Toxocariasis caused by Toxocara canis or less frequently by T.catis is a common parasitic infection worldwide. Clinical spectrum in humans can vary from asymptomatic infection to serious organ disfunction depending on the load of parasite, migration target of the larva and the inflammatory response of the host. Transverse myelitis (TM) due to toxocariasis is an uncommon illness identified mainly as case reports in literature. In this report, a case of TM who was diagnosed as neurotoxocariasis by serological findings has been presented...
July 2016: Mikrobiyoloji Bülteni
Mohammad Zibaei, Shoji Uga
Human toxocariasis, extraintestinal-migration of Toxocara species, is a worldwide helminthic zoonosis in many places of the undeveloped countries. Toxocara cati is one of the common helminths in cats and it is a potentially preventable disease. Its diagnosis and treatment depend on the demonstration of specific excretory-secretory Toxocara antibodies from Toxocara larvae by immunological assays. This study provides a simple manual technique which can be performed in any laboratory for recovering a large number of Toxocara cati larvae from the thick-shelled eggs...
October 2016: Experimental Parasitology
Mohammad Zibaei
Toxocariasis is the clinical term used to describe human infection with either the dog ascarid Toxocara canis or the feline ascarid Toxocara cati. As with other helminths zoonoses, the infective larvae of these Toxocara species cannot mature into adults in the human host. Instead, the worms wander through organs and tissues, mainly the liver, lungs, myocardium, kidney and central nervous system, in a vain attempt to find that, which they need to mature into adults. The migration of these immature nematode larvae causes local and systemic inflammation, resulting in the "larva migrans" syndrome...
August 3, 2016: Current Cardiology Reviews
Ki Woong Bae, Seong Joon Ahn, Kyu Hyung Park, Se Joon Woo
PURPOSE: This study evaluated the prevalence of ocular toxocariasis (OT) in patients with uveitis of unknown etiology who visited a tertiary hospital in South Korea and assessed the success of serum anti-Toxocara immunoglobulin G (IgG) enzyme-linked immunosorbent assay (ELISA) as a diagnostic test for OT. METHODS: The records of consecutive patients with intraocular inflammation of unknown etiology were reviewed. All participants underwent clinical and laboratory investigations, including ELISA for serum anti-Toxocara IgG...
August 2016: Korean Journal of Ophthalmology: KJO
G-L Yang, X-X Zhang, C-W Shi, W-T Yang, Y-L Jiang, Z-T Wei, C-F Wang, Q Zhao
Toxocariasis is a very prevalent zoonotic disease worldwide. Recently, investigators have focused more on Toxocara spp. seroprevalence in humans. Information regarding Toxocara seroprevalence in people from different ethnic backgrounds in China is limited. For this study, blood samples were collected from a total of 802 Han, 520 Korean, 303 Manchu, and 217 Mongol subjects from Jilin and Shandong provinces. The overall Toxocara seroprevalence was 16·07% (14·21% Han, 20·58% Korean, 11·22% Manchu, 18·89% Mongol)...
October 2016: Epidemiology and Infection
Maysa Ahmad Eraky, Soha Abdel-Hady, Karim Fetouh Abdallah
The present study aimed to investigate the possible association of Toxoplasma gondii and Toxocara spp. infections with cryptogenic epilepsy in children. The study was carried out between June 2014 and March 2015. Total 90 children (40 with cryptogenic epilepsy, 30 with non-cryptogenic epilepsy, and 20 healthy control children) were evaluated to determine the anti-Toxocara and anti-T. gondii IgG seropositivity using ELISA kits. Epileptic cases were selected from those attending the pediatrics outpatient clinic of Benha University Hospital, Pediatrics Neurology Unit, and from Benha Specialized Hospital of children...
June 2016: Korean Journal of Parasitology
P C Santos, P L Telmo, L M Lehmann, G T Mattos, G B Klafke, C Lorenzi, C Hirsch, L Lemos, M E A Berne, C V Gonçalves, C J Scaini
Toxoplasmosis causes complications during pregnancy that have serious effects on fetal development. Thus far, toxocariasis has been reported to spread only via vertical transmission. Nonetheless, the population of pregnant women is also exposed to this infection. Co-infection with both Toxoplasma gondii and Toxocara spp. has been reported in children, but there are no reports of co-infection in the population of pregnant women. The aim of this study was to determine the prevalence of co-infection with T. gondii and Toxocara spp...
July 14, 2016: Journal of Helminthology
D Jorge, C Strady, B Guy, G Deslée, F Lebargy, S Dury
INTRODUCTION: Toxocariasis is a parasitosis which complicates the accidental infestation of the humans by larvae of a roundworms belonging of the genus Toxocara. In adults, the discovery is often incidental during a hypereosinophilia check-up. Clinical signs are not specific and depend on affected organs. CASE REPORT: We report the case of a 53-year-old-woman who has consulted for a recent cough, after spontaneous resolution of abdominal pain. The laboratory examination isolated an hypereosinophilia and the liver sonography showed two hypoechogenic nodules...
August 2016: Revue de Pneumologie Clinique
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