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https://www.readbyqxmd.com/read/29288706/improved-vaginal-retention-and-enhanced-antifungal-activity-of-miconazole-microsponges-gel-formulation-development-and-in-vivo-therapeutic-efficacy-in-rats
#1
Salwa Salah, Ghada E A Awad, Amal I A Makhlouf
Traditional azole antifungal formulations suffer from poor retention in the vaginal cavity, irritation and burning of the vaginal area. In the present work, we aim at the development of a novel miconazole (MCZ) microsponges gel as an attractive dosage form for vaginal candidiasis. The proposed formula has the potential to minimize the local side effects of the drug due to the controlled release characteristic, which increases patient compliance. Moreover, the mucosal retention effect of the microsponges in addition to the bioadhesion property of Carbopol gel prolongs the retention of the dosage form in the vagina and consequently improves the therapeutic efficiency...
December 27, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29278373/risk-assessment-and-implication-of-human-exposure-to-road-dust-heavy-metals-in-jeddah-saudi-arabia
#2
Ibrahim I Shabbaj, Mansour A Alghamdi, Magdy Shamy, Salwa K Hassan, Musaab M Alsharif, Mamdouh I Khoder
Data dealing with the assessment of heavy metal pollution in road dusts in Jeddah, Saudi Arabia and its implication to human health risk of human exposure to heavy metals, are scarce. Road dusts were collected from five different functional areas (traffic areas (TA), parking areas (PA), residential areas (RA), mixed residential commercial areas (MCRA) and suburban areas (SA)) in Jeddah and one in a rural area (RUA) in Hada Al Sham. We aimed to measure the pollution levels of heavy metals and estimate their health risk of human exposure applying risk assessment models described by United States Environmental Protection Agency (USEPA)...
December 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29274208/the-light-microscopy-and-ultrastructural-characteristics-of-myxobolus-naffari-myxosporea-myxobolidae-infecting-the-nile-carp-labeo-niloticus-cyprinidae-and-its-histological-impact
#3
Naksheen M Ardalan, Salam F Al-Hashimi, Manal El Garhy, Salwa AH Hamdi, Ali Al Ghamdi, Kareem Morsy
During a survey of myxosporean parasites infecting freshwater fishes from the River Nile at Giza Governorates, Egypt between March and September 2016, nine out of 30 specimens of the Nile carp Labeo niloticus (Cyprinidae) were found to be naturally infected with Myxobolus naffari (Myxobolidae). Small macroscopic plasmodia appeared embedded in the host gill tissue accompanied with fusion of the gill epithelia, and atrophy was observed at the site of infection. The host reaction was manifested by the encapsulation of the plasmodia with a thick layer of connective tissue...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/29258491/dental-and-medical-health-status-and-oral-health-knowledge-among-visually-impaired-and-sighted-female-schoolchildren-in-riyadh-a-comparative-study
#4
Salwa A AlSadhan, Asma M Al-Jobair, Mariam Bafaqeeh, Hanadi Abusharifa, Maram Alagla
BACKGROUND: The impact of visual impairment on oral health in the literature is inconclusive, and the available information on the medical and dental health status of visually impaired children is limited. The aim of this study was to evaluate the dental and medical health status, and to assess the oral health knowledge of visually impaired girls aged 6-12 years, and compare them to that of sighted children. METHODS: This analytical cross-sectional study was carried out on 79 visually impaired and 83 age-matched sighted female primary school children...
December 19, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29249235/kidney-stone-composition-in-the-kingdom-of-saudi-arabia%C3%A2
#5
Abdulrazack Amir, Brian R Matlaga, Justin B Ziemba, Salwa Sheikh
INTRODUCTION: Urolithiasis is a globally-distributed disease; however, its prevalence varies across countries and regions. Countries in the Middle East have been reported to have particularly high nephrolithiasis prevalence rates. To date, however, we have an incomplete understanding of the composition of stones seen in this region. Therefore, we performed a study to characterize stone composition over a 14-year period in the Eastern Province of the Kingdom of Saudi Arabia (KSA). MATERIALS AND METHODS: A retrospective review of all adult patients who had the composition of their upper urinary tract calculi analyzed at Johns Hopkins Aramco Healthcare (JHAH) between 1999 and 2013 was performed...
December 18, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29239484/inactivation-of-middle-east-respiratory-syndrome-coronavirus-in-human-plasma-using-amotosalen-and-ultraviolet-a-light
#6
Salwa I Hindawi, Anwar M Hashem, Ghazi A Damanhouri, Sherif A El-Kafrawy, Ahmed M Tolah, Ahmed M Hassan, Esam I Azhar
BACKGROUND: Middle East respiratory syndrome-coronavirus (MERS-CoV) is a novel zoonotic pathogen. Although the potential for MERS-CoV transmission through blood transfusion is not clear, MERS-CoV was recognized as a pathogen of concern for the safety of the blood supply especially after its detection in whole blood, serum, and plasma of infected individuals. Here we investigated the efficacy of amotosalen and ultraviolet A light (UVA) to inactivate MERS-CoV in fresh-frozen plasma (FFP)...
December 14, 2017: Transfusion
https://www.readbyqxmd.com/read/29235903/brain-targeted-intranasal-zaleplon-solid-dispersion-in-hydrophilic-carrier-system-23-full-factorial-design-and-in-vivo-determination-of-gaba-neurotransmitter
#7
Eman Abd-Elrasheed, Sara Nageeb El-Helaly, Manal M El-Ashmoony, Salwa Salah
Intranasal Zaleplon solid dispersion was formulated to enhance the solubility, bioavailability and deliver an effective therapy. Zaleplon belongs to Class II drugs, and undergoes extensive first-pass metabolism after oral absorption exhibiting 30% bioavailability. A 23full factorial design was chosen for the investigation of solid dispersion formulations. The effects of different variables include drug to carrier ratio (1:1 and 1:2), carrier type (polyethylene glycol 4000 and poloxamer 407), and preparation method (solvent evaporation and freeze drying) on different dissolution parameters were studied...
December 13, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29231258/retrospective-review-of-immunocompromised-children-undergoing-skin-biopsy-for-suspected-invasive-infection-analysis-of-factors-predictive-of-invasive-mold
#8
Robert J Smith, Sarah B Klieger, Salwa E Sulieman, Emily Berger, James R Treat, Brian T Fisher
OBJECTIVES: Cutaneous lesions are often the first marker of invasive mold infection, which can cause substantial morbidity in immunocompromised children. The purpose of this study was to describe the evaluation and outcomes of immunocompromised children who presented with findings requiring skin biopsy because of concern about invasive infection. In children who were biopsied, we sought to determine the factors predictive of invasive mold infection. METHODS: A retrospective review was conducted at the Children's Hospital of Philadelphia...
December 12, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29225641/foramen-changes-following-over-instrumentation-of-curved-canals-with-three-engine-driven-instruments-an-in-vitro-study
#9
Salwa Yammine, Edgard Jabbour, Paul Nahas, Zeina Majzoub
Introduction: The present in vitro study aimed to evaluate and compare the changes in shape and surface area of the major foramen following shaping of curved canals with three new generation NiTi engine-driven instruments naming ProTaper Next, BT RaCe and WaveOne Gold- with 3 different levels of protrusion beyond the major apical foramen. Methods and Materials: A total of 45 extracted human molars with at least one curved canal were distributed in 3 comparable groups of 15 that were instrumented using either ProTaper Next (PTN), BT RaCe (BTR) or WaveOne Gold (WOG)...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/29224587/the-prevalence-of-beh%C3%A3-et-s-disease-in-the-north-of-jordan-a-hospital-based-epidemiological-survey
#10
Wafa Y Madanat, Khaldoon M Alawneh, Mahmoud M Smadi, Salwa S Saadeh, Muntasser M Omari, Anas B Bani Hani, Hasan Yazici
OBJECTIVES: To estimate the prevalence of Behçet's disease (BD) in Jordan, with the additional aim of comparing this prevalence among hospital workers in other geographical areas. METHODS: In the first stage of our survey, 2,569 employees from 6 hospitals in north Jordan were interviewed using a screening questionnaire to identify individuals with recurrent oral ulcers (ROU), a previous diagnosis of BD (PDBD) and/or any major symptom related to BD. In the second stage, all individuals with ROU or PDBD identified at stage 1, were examined by 2 rheumatologists for the presence/confirmation of BD according to the International Study Group (ISG) criteria...
November 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29219144/apical-pseudoaneurysm-after-transapical-transcatheter-aortic-valve-implantation
#11
Agata Krawczyk-Ożóg, Danuta Sorysz, Artur Dziewierz, Renata Rajtar-Salwa, Marzena Daniec, Dariusz Dudek
No abstract text is available yet for this article.
December 8, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29219053/triazolopyrimidines-and-thiazolopyrimidines-synthesis-anti-hsv-1-cytotoxicity-and-mechanism-of-action
#12
Salwa F Mohamed, Eman M H Abbas, Hemat S Khalaf, Thoraya A Farghaly, Dina N Abd El-Shafy
Merged pyrimidine derivatives were designed by one pot synthesis of pyrimidinethione derivative with halogenated compounds. The structure of all prepared compounds was characterized by their spectroscopic data and also, their ability to inhibit the in vitro replication of HSV-1 was estimated. Amongst the tested compounds 2-acetyl-3-methyl-5-(p-tolyl)indeno[1,2-d]thiazolo[3,2-a]pyrimidin-6(5H)-one (9b) and ethyl 3-methyl-6-oxo-5-(p-tolyl)-5,6-dihydroindeno[1,2-d]thiazolo[3,2-a]pyrimidine-2-carboxylate (9c), caused viral inhibition over 90%...
December 7, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29210947/toward-optimizing-cervical-vestibular-evoked-myogenic-potentials-cvemp-combining-air-bone-gap-and-cvemp-thresholds-to-improve-diagnosis-of-superior-canal-dehiscence
#13
Kimberley S Noij, Maria J Duarte, Kevin Wong, Y Song Cheng, Salwa Masud, Barbara S Herrmann, Hugh D Curtin, Vivek V Kanumuri, John J Guinan, Elliott D Kozin, Osama Tarabichi, David H Jung, Daniel J Lee, Steven D Rauch
OBJECTIVE: To develop a novel approach combining low-frequency air-bone gap (ABG) and cervical vestibular evoked myogenic potential (cVEMP) thresholds to improve screening for superior canal dehiscence (SCD) syndrome. STUDY DESIGN: Retrospective study. SETTING: Tertiary care center. PATIENTS: One hundred forty patients with SCD and 21 healthy age-matched controls were included. Ears for each patient were divided into three groups based on computed tomography (CT) findings: 1) dehiscent, 2) thin, or 3) unaffected...
November 28, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29203378/occurrence-of-acanthamoeba-genotypes-in-central-west-malaysian-environments
#14
Mohamad Hafiz Abdul Basher, Init Ithoi, Rohela Mahmud, Awatif Mohamed Abdulsalam, Agus Iwan Foead, Salwa Dawaki, Wahib Mohammed Mohsen Atroosh, Veeranoot Nissapatorn, Wan Omar Abdullah
Acanthamoeba species are ubiquitous free-living protozoa that can be found worldwide. Occasionally, it can become parasitic and the causative agent of acanthamoebic keratitis (AK) and Granulomatous Amoebic Encephalitis (GAE) in man. A total of 160 environmental samples and 225 naturally-infected animal corneal swabs were collected for Acanthamoeba cultivation. Acanthamoeba was found to be high in samples collected from environments (85%, 136/160) compared to infected animal corneas (24.89%, 56/225) by microscopic examination...
December 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29189154/brain-targeted-intranasal-zaleplon-nano-emulsion-in-vitro-characterization-and-assessment-of-gamma-aminobutyric-acid-levels-in-rabbits-brain-and-plasma-at-low-and-high-doses
#15
Eman Abd-Elrasheed, Sara Nageeb El-Helaly, Manal M El-Ashmoony, Salwa Salah
BACKGROUND: Zaleplon is a pyrazolopyrimidin derivative hypnotic drug indicated for the short-term management of insomnia. Zaleplon belongs to Class II drugs, according to the biopharmaceutical classification system (BCS), showing poor solubility and high permeability. It undergoes extensive first-pass hepatic metabolism after oral absorption, with only 30% of Zaleplon being systemically available. It is available in tablet form which is unable to overcome the previous problems. OBJECTIVE: The aim of this study is to enhance solubility and bioavailability via utilizing nanotechnology in the formulation of intranasal Zaleplon nano-emulsion (ZP-NE) to bypass the barriers and deliver an effective therapy to the brain...
November 30, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29181228/knowledge-of-warning-signs-presenting-symptoms-and-risk-factors-of-coronary-heart-disease-among-the-population-of-dubai-and-northern-emirates-in-uae-a-cross-sectional-study
#16
Nelofar Sami Khan, Syed Ilyas Shehnaz, Gomathi Kadayam Guruswami, Salwa Abdelzaher Mabrouk Ibrahim, Sana Abdul Jabbar Mustafa
Background: To evaluate the level of knowledge regarding warning signs, presenting symptoms and risk factors associated with coronary heart disease (CHD) among population of Dubai and Northern Emirates in UAE. Materials and Methods: A cross sectional survey of 1367 residents of Dubai and Northern Emirates was conducted using a self-administered questionnaire. Results: Respondents were classified into two groups: Young Adult Population (YAP; 18-24 years of age) and General Population (GP; 25 years and older)...
June 2017: Nepal Journal of Epidemiology
https://www.readbyqxmd.com/read/29181142/molecular-screening-for-malaria-among-blood-donors-in-a-who-claimed-region-of-egypt-fayoum-governorate
#17
Salwa Bakr, Sherif Edris, Nashwa S Abdel Fattah, Noha Mohamed Ibrahim, Manal F El-Khadragy
Background: Transfusion-transmitted malaria is undoubtedly a potential health hazard for blood recipients. Egypt is still on the prevention of reintroduction phase of malaria control program. Fayoum Governorate is considered one of the high-risk foci in Egypt due to its geology. However, no studies have been reported to evaluate the current status of subclinical Plasmodium infection based on sensitive molecular techniques. Moreover, screening of malaria is not listed within screening protocols of blood-borne pathogens in Fayoum blood banks...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29175586/design-synthesis-of-novel-triazolones-and-bis-triazolones-derivatives-under-ultrasound-irradiation-and-evaluation-as-potent-angiotensin-converting-enzyme-ace-inhibitors
#18
Bochra Ben Salah, Salwa Hamzaoui, Fatma Krichen, Ikram Saadaoui, Riadh Ben Mansour, Nabil Miled, Ali Bougatef, Mohamed Kossentini
The condensation of several primary amines and diamines with various N1-ethoxycarbonyles N1-tosylhydrazonates (1a-b), triazolones (2) and bis-triazolone (3) resulted in ethanol under ultrasound irradiation. Compared with the conventional methods, the main advantages of the present procedure are milder conditions, shorter reaction time and higher yields. The newly synthesized compounds were evaluated for angiotensin I-converting enzyme (ACE) inhibition. The results were compared to Captopril as a reference drug...
November 17, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29171116/impact-of-weight-loss-on-ablation-outcome-in-obese-patients-with-longstanding-persistent-atrial-fibrillation
#19
Sanghamitra Mohanty, Prasant Mohanty, Veronica Natale, Chintan Trivedi, Carola Gianni, J David Burkhardt, Javier E Sanchez, Rodney Horton, G Joseph Gallinghouse, Richard Hongo, Salwa Beheiry, Amin Al-Ahmad, Luigi Di Biase, Andrea Natale
AIMS: This study investigated the impact of weight loss in longstanding persistent (LSPAF) patients undergoing catheter ablation (CA). METHODS: Ninety consecutive obese LSPAF patients were approached; 58 volunteered to try weight loss interventions for up to 1 year (Group 1), while 32 patients declined weight loss interventions and were included as a control (Group 2). Both groups remained on antiarrhythmic drugs. If they continued to experience AF, CA was performed...
November 24, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29168411/primary-healthcare-policy-implementation-in-the-eastern-mediterranean-region-experiences-of-six-countries
#20
Chris van Weel, Faisal Alnasir, Taghreed Farahat, Jinan Usta, Mona Osman, Mariam Abdulmalik, Nagwa Nashat, Wadeia Mohamed Alsharief, Salwa Sanousi, Hassan Saleh, Mohammed Tarawneh, Felicity Goodyear-Smith, Amanda Howe, Ryuki Kassai
BACKGROUND: Primary healthcare (PHC) is essential for equitable access and cost-effective healthcare. This makes PHC a key factor in the global strategy for universal health coverage (UHC). Implementing PHC requires an understanding of the health system under prevailing circumstances, but for most countries, no data are available. OBJECTIVES: This paper describes and analyses the health systems of Bahrain, Egypt, Lebanon, Qatar, Sudan and the United Arab Emirates, in relation to PHC...
November 23, 2017: European Journal of General Practice
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