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https://www.readbyqxmd.com/read/28515509/anti-nuclear-cytoplasmic-antibody-associated-vasculitis-a-probable-adverse-effect-of-sofosbuvir-treatment-in-chronic-hepatitis-c-patients
#1
Youssef K Ahmad, Salwa Tawfeek, Mohamed Sharaf-Eldin, Hassan E Elbatea, Abdelrahman Kobtan, Ferial El-Kalla, Rehab Badawi, Sherief Abd-Elsalam
Background: Egypt has the largest hepatitis C virus (HCV) epidemic worldwide. Sofosbuvir is an antiviral drug acting by inhibition of the HCV NS5B polymerase. It has shown high efficacy in combination with several other drugs and has a low reported rate of side effects. Objective: The aim of this prospective cohort study was to assess the safety of sofosbuvir-based treatment regimens used to treat chronic hepatitis C infections and to detect any side effects of sofosbuvir not previously reported. Methods: We studied treatment side effects in 3,000 patients with chronic HCV infection treated with sofosbuvir and ribavirin for 24 weeks or treated by pegylated interferon, sofosbuvir, and ribavirin triple therapy for 12 weeks...
April 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28486578/development-of-a-validated-comparative-stability-indicating-assay-method-for-some-h2-receptor-antagonists
#2
Sameh Ahmed, Salwa R Elshaboury, Niveen A Mohamed, Shereen Farrag
A comparative force degradation high performance thin layer chromatography (HPTLC) method was developed and validated for some H2-receptor antagonists. The studied H2-receptor antagonists were ranitidine (RAN), nizatidine (NIZ) and famotidine (FAM). The degradation behaviors of the studied H2-receptor antagonists were studied under different stress conditions (hydrolytic, thermal and oxidative) conditions as well as storage conditions according to International Conference on Harmonization (ICH) recommendations...
May 9, 2017: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/28482597/electrochemical-hydroxyapatite-cobalt-ferrite-nanocomposite-coatings-as-well-hyperthermia-treatment-of-cancer
#3
Z Abdel-Hamid, M M Rashad, Salwa M Mahmoud, A T Kandil
The fabrication of hydroxyapatite-Co-ferrite nanocomposite coatings was performed on stainless steel by chronoamperometry technique. HA-CoFe2O4 nanocomposite films were characterized using X-ray diffraction, scanning electron microscopy, and vibrating sample magnetometer (VSM). The results reveal that CoFe2O4 nanoparticles dispersed within the HA matrix have flake and strip shapes. The magnetic property of the nanocomposite was increased by increasing the concentration of CoFe2O4 and a good saturation magnetization value was found to be 20...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28474494/a-putative-association-of-interleukin-10-promoter-polymorphisms-with-cardiovascular-disease
#4
Shams Tabrez, Murtaza Ali, Nasimudeen R Jabir, Chelapram K Firoz, Ghulam Md Ashraf, Salwa Hindawi, Ghazi A Damanhouri, Mohammed Nabil Alama
Interleukin-10 (IL-10) is an anti inflammatory cytokine involved in the ongoing coronary inflammation and related patho-physiological processes. The piece of work presented herein is aimed at investigating possible association of polymorphisms in IL-10 promoter with Saudi cardiovascular disease (CVD) patients. The study included 80 confirmed CVD patients with diabetes and 75 healthy control individuals both men and women. Concentration of IL-10 in the serum samples were measured by ELISA method. For single nucleotide polymorphism (SNP) analysis, Sanger method of DNA sequencing was followed...
May 5, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28458730/complications-during-maxillary-sinus-augmentation-associated-with-interfering-septa-a-new-classification-of-septa
#5
Tassos Irinakis, Valentin Dabuleanu, Salwa Aldahlawi
PURPOSE: A new classification of maxillary sinus interfering septa based on its orientation is presented along with its relationship to the prevalence and severity of sinus membrane perforations. Additionally, the impact of membrane perforation on post-operative complications and marginal bone loss during the first year of loading is evaluated. MATERIALS & METHODS: Retrospective chart review of 79 consecutive sinus lift procedures with lateral window technique and 107 implants...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28443521/synthesis-anticancer-screening-and-molecular-docking-studies-of-new-heterocycles-with-trimethoxyphenyl-scaffold-as-combretastatin-analogues
#6
Korany A Ali, Naglaa A Abdel Hafez, Mohamed A Elsayed, Manal M Elshahawi, Salwa M El-Hallouty, Abd El-Galil E Amr
In this study, synthesis, molecular docking and anticancer screening of new series of substituted heterocycles with trimethoxy phenyl scaffold as Combretastatin analogues were described. Substituted pyridines were synthesized via reaction of (E)-3-(dimethylamino)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one (2)with active methylene reagents. Substituted pyrimidines were prepared by the reaction of the enaminone (2) with heterocyclic amines and 6-amino thiouracil. Furthermore, a series of pyrazoles substituted with trimethoxyphenyl scaffold were prepared by reaction of the enaminone 2, with selected examples of hydrazonoyl halides...
April 24, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28434857/a-study-evaluating-the-postprandial-plasma-glucose-control-among-type-2-diabetes-patients-attending-a-teaching-hospital-in-malaysia
#7
REVIEW
Salwa Selim Ibrahim Abougalambou, Nahid Osman Ahmed, Ayman S Abougalambou
BACKGROUND AND OBJECTIVE: Type 2 DM is rapidly rising as a global health care problem that threatens to reach pandemic levels by 2030. Type 2 diabetes mellitus is a disease with no cure and chronic disease that results in major morbidity and mortality. The main objective of this study is to evaluate postprandial plasma glucose level and to determine factors affect on postprandial plasma glucose level among type 2 diabetes outpatients attending endocrinology clinics at Hospital Universiti Sains Malaysia, Teaching Hospital...
April 10, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28429836/increased-levels-of-soluble-hla-g-molecules-in-tunisian-patients-with-chronic-hepatitis-b-infection
#8
Ahmed Baligh Laaribi, Daria Bortolotti, Naila Hannachi, Asma Mehri, Olfa Hazgui, Hamza Ben Yahia, Wafa Babay, Manel Belhadj, Houda Chaouech, Salwa Yacoub, Amel Letaief, Imene Ouzari, Abdellatif Boudabous, Dario Di Luca, Jalel Boukadida, Roberta Rizzo, Ines Zidi
Hepatitis B virus (HBV) infection is a global health problem. The mechanisms of immune tolerance in HBV infection are still unclear. The host immune response plays a critical role in determining the outcome of HBV infection. Human leukocyte antigen-G (HLA-G) is involved in immunotolerogenic process and infectious diseases. The present study aimed to explore the implication of soluble HLA-G (sHLA-G) and its isoforms in HBV infection. Total sHLA-G (including shedding HLA-G1 and HLA-G5) was analysed by ELISA in 95 chronic HBV patients, 83 spontaneously resolvers and 100 healthy controls...
April 21, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/28414590/reduction-in-cd16-cd56-and-cd16-cd3-cd56-natural-killer-cells-in-coronary-artery-disease
#9
Nasimudeen R Jabir, Chelapram K Firoz, Farid Ahmed, Mohammad A Kamal, Salwa Hindawi, Ghazi A Damanhouri, Hussein A Almehdar, Shams Tabrez
BACKGROUND: Natural killer (NK) cells are the potential modulators of inflammatory reactions that exert several unique biological effects and could lead to future adverse events of coronary artery disease (CAD). HYPOTHESIS: The purpose of this study was to find out the possible association of modulation in NK cell, TNK cells, T cells, B cells, and tumor necrosis factor alpha (TNF-α) in CAD patients and various forms of myocardial infarction. METHODS: The present study included total 190 subjects (98 confirmed CAD patients both men and women and 92 healthy control individuals)...
April 17, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28393667/disability-quality-of-life-and-pain-coping-in-pediatric-migraine-an-observational-study
#10
Serena L Orr, Suzanne N Christie, Salwa Akiki, Hugh J McMillan
OBJECTIVES: The objective was to examine the relationship between disability, health-related quality of life (HrQoL), and pain coping in pediatric migraineurs. METHOD: Eighty-five patients with migraine were recruited from Pediatric Neurology clinics. Participants completed the Pediatric Migraine Disability Assessment Scale, the Pediatric Quality of Life Inventory, the Pain Coping Questionnaire, and the Pain Catastrophizing Scale. Means were compared to published norms using t-tests...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28387052/examining-trends-in-type-2-diabetes-incidence-prevalence-and-mortality-in-the-uk-between-2004-and-2014
#11
Salwa S Zghebi, Douglas T Steinke, Matthew J Carr, Martin K Rutter, Richard A Emsley, Darren M Ashcroft
AIMS: Contemporary data describing type 2 diabetes prevalence, incidence and mortality are limited. We aimed to (i) estimate annual incidence and prevalence rates of type 2 diabetes in the UK between 2004 and 2014; (ii) examine relationships between observed rates with age, gender, socio-economic status and geographic region; and (iii) assess how temporal changes in incidence and all-cause mortality rates influence changes in prevalence. METHODS: Type 2 diabetes cases aged ≥16 years between January 2004 and December 2014 were identified using the Clinical Practice Research Datalink (CPRD)...
April 7, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28377546/high-prevalence-of-coronary-artery-calcification-in-saudi-patients-with-normal-myocardial-perfusion
#12
Ahmed L Fathala, Salwa Q Bukhari, Mohamed Shoukri, Hani El Sergani, Bandar Al-Ghamdi, Abdulaziz Al-Sugair
BACKGROUND: Normal single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) has a high negative predictive value for ischemic heart disease. Thus, the presence of subclinical coronary atherosclerosis detected by coronary artery calcification (CAC) score in patients who have under-gone SPECT MPI is unknown. OBJECTIVES: Determine the prevalence of coronary artery calcification (CAC) in patients with normal SPECT MPI and examine the association of CAC with conventional coronary artery disease (CAD) risk factors...
March 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28376548/effect-of-an-educational-presentation-about-extremely-preterm-infants-on-knowledge-and-attitudes-of-health-care-providers
#13
Stefani Doucette, Brigitte Lemyre, Thierry Daboval, Sandra Dunn, Salwa Akiki, Nick Barrowman, Gregory P Moore
Objective To determine healthcare providers' knowledge (HCP) about survival rates of extremely preterm infants (EPI) and attitudes toward resuscitation before and after an educational presentation and, to examine the relationship between knowledge and attitudes toward resuscitation. Study Design Participants completed a survey before and after attending a presentation detailing evidence-based estimates of survival rates and surrounding ethical issues. Respondents included neonatologists, obstetricians, pediatricians, maternal-fetal medicine specialists, trainees in pediatrics, obstetrics, neonatal-perinatal medicine and neonatal and obstetrical nurses...
April 4, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28365630/thrombolysis-and-thrombectomy-for-acute-ischaemic-stroke
#14
Salwa El Tawil, Keith W Muir
The likelihood of disability-free recovery after acute ischemic stroke is significantly improved by reperfusion either by intravenous thrombolytic drug treatment or with endovascular mechanical thrombectomy in selected cases. The use of intravenous thrombolysis is limited by the short treatment window and you need to assess individual balance of benefit and risk of symptomatic intracranial haemorrhage. Benefit is greater for shorter onset-to-reperfusion time intervals, requiring optimisation of pre-hospital and in-hospital pathways...
April 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/28363654/production-of-exopolysaccharides-by-selected-bacillus-strains-optimization-of-media-composition-to-maximize-the-yield-and-structural-characterization
#15
Afshan Malick, Nastaran Khodaei, Noreddine Benkerroum, Salwa Karboune
Selected Bacillus strains were investigated for the production of exopolysaccharides (EPS) by fermentation in three different culture media: (i) mineral base-medium with added yeast extract (M1), (ii) succinate-containing mineral base-medium with added yeast extract (M2) and (iii) tryptone and yeast extract-containing base-medium (M3). Modest EPS yield of 6.7g/L was recorded for Bacillus amyloliquefaciens 23350 grown on M1, where the EPS produced was characterized by a low MW (<5kDa) and of being mainly glucans...
March 29, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28362355/daily-intake-of-grape-powder-prevents-the-progression-of-kidney-disease-in-obese-type-2-diabetic-zsf1-rats
#16
Salwa M K Almomen, Qiunong Guan, Peihe Liang, Kaidi Yang, Ahmad M Sidiqi, Adeera Levin, Caigan Du
Individuals living with metabolic syndrome (MetS) such as diabetes and obesity are at high risk for developing chronic kidney disease (CKD). This study investigated the beneficial effect of whole grape powder (WGP) diet on MetS-associated CKD. Obese diabetic ZSF1 rats, a kidney disease model with MetS, were fed WGP (5%, w/w) diet for six months. Kidney disease was determined using blood and urine chemical analyses, and histology. When compared to Vehicle controls, WGP intake did not change the rat bodyweight, but lowered their kidney, liver and spleen weight, which were in parallel with the lower serum glucose and the higher albumin or albumin/globin ratio...
March 31, 2017: Nutrients
https://www.readbyqxmd.com/read/28357833/the-assessment-of-seafarers-knowledge-attitudes-and-practices-related-to-sti-hiv-aids-in-northern-morocco
#17
Salwa Laraqui, Omar Laraqui, Nadia Manar, Tarik Ghailan, Mohamed Belabsir, Frederic Deschamps, Chakib H Laraqui
BACKGROUND: The purpose of this study was to assess the knowledge, attitudes and practices of seafarers in relation to sexually transmitted infections (STI) and human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS). MATERIALS AND METHODS: This transversal, descriptive and behavioural study was conducted in 2014 on a representative sample of 1447 seafarers. RESULTS: The rate of participation was 95%. The mean age was 36...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28357832/prevalence-of-consumption-of-addictive-substances-amongst-moroccan-fishermen
#18
Omar Laraqui, Salwa Laraqui, Nadia Manar, Tarik Ghailan, Frederic Deschamps, Chakib H Laraqui
BACKGROUND: The prevalence of toxic habits is constantly increasing in developing countries and all professional sectors are concerned. Seafarers are a particular target because of the dangerousness and complexity of their work. However, few studies have investigated toxic habits in this population. The aim of the study was to determine the prevalence of the use and misuse of addictive substances in seafarers and to appreciate poly-consumptions according to socio-demographic and occupational characteristics...
2017: International Maritime Health
https://www.readbyqxmd.com/read/28330941/nurse-driven-clinical-pathway-for-inpatient-asthma-a-randomized-controlled-trial
#19
Catherine M Pound, Victoria Gelt, Salwa Akiki, Kaylee Eady, Katherine Moreau, Franco Momoli, Barbara Murchison, Roger Zemek, Brett Mulholland, Tom Kovesi
OBJECTIVE: We examined the impact of a nurse-driven clinical pathway on length of stay (LOS) for children hospitalized with asthma. METHODS: We conducted a randomized controlled trial involving children hospitalized with asthma. Nurses of children in the intervention group weaned salbutamol frequency using an asthma scoring tool, whereas physicians weaned salbutamol frequency for the control group patients as per standard care. The primary outcome was LOS in hours...
April 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28316424/ovicidal-effect-of-chitinase-and-protease-enzymes-produced-by-soil-fungi-on-the-camel-tick-hyalomma-dromedarii-eggs-acari-ixodidae
#20
Salwa M Habeeb, Heba M Ashry, Moataza M Saad
The aim of this study was to evaluate the effect of chitinase and protease enzymes produced by environmentally safe soil Fungi; Aspergillus sp. NRC 4/5H; Mucor sp. NRC 5; Trichoderma sp. NRC 4/56; Aspergillus sojae; Mucor ranosisinus; Aspergillus oryzae on embryo development of the camel tick Hyalomma dromedarii eggs. The experiment was carried out on the 7 day aged eggs. Concentrations of the chitinase and protease crude enzymes [1:1, 1:2, 1:3, 1:4 and 1:5 (v/v)] were prepared from six stock solutions whose concentrations were 5 units/ml each...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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