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https://www.readbyqxmd.com/read/29753282/efficient-hptlc-dual-wavelength-spectrodensitometric-method-for-simultaneous-determination-of-sofosbuvir-and-daclatasvir-biological-and-pharmaceutical-analysis
#1
Mohammad Nabil Abo-Zeid, Samia M El-Gizawy, Noha N Atia, Salwa R El-Shaboury
Sofosbuvir (SOF) and daclatasvir (DCS) are newly discovered anti-hepatitis C drugs that have direct antiviral activity. A novel and simple high-performance thin-layer chromatography (HPTLC) method was designed for simultaneous determination of SOF and DCS in miscellaneous matrices. The method adopts coupling HPTLC with dual wavelength spectrodensitometry. Consequently, this enabled sensitive, specific and cost-effective determination of the SOF-DCS mixture. The developed HPTLC procedure is based on a simple liquid-liquid extraction, enrichment of the analytes and subsequent chromatographic separation with UV detection...
May 1, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29748941/health-risk-behaviours-of-palestinian-youth-findings-from-a-representative-survey
#2
Peter Glick, Umaiyeh Al-Khammash, Mohammed Shaheen, Ryan Brown, Prodyumna Goutam, Rita Karam, Sebastian Linnemayr, Salwa Massad
Background: There is little systematic information about health risk behaviours among youth in Middle Eastern countries, leaving public health authorities unprepared to deal with emerging public health threats at a time of major social change. Aim: The Palestinian Youth Health Risk study investigates patterns of risk behaviours among Palestinian youth, their perceptions of the risks and benefits of such behaviours, and the relationship of exposure to violence with mental health and engagement in risk behaviours...
May 3, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29743915/anginal-pain-and-elevated-troponin-level-despite-normal-coronary-angiography-hypertrophic-cardiomyopathy-with-severe-obstruction-due-to-vasodilator-diuretic-therapy-for-coincident-arterial-hypertension
#3
Adam Gębka, Renata Rajtar-Salwa, Rafał Hładij, Paweł Petkow Dimitrow
No abstract text is available yet for this article.
2018: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/29739353/changes-in-serum-prolactin-level-during-intracytoplasmic-sperm-injection-and-effect-on-clinical-pregnancy-rate-a-prospective-observational-study
#4
Ahmed Kamel, Ayman A Halim, Mohamed Shehata, Salwa AlFarra, Yahia El-Faissal, Wafaa Ramadan, Ahmed M Hussein
BACKGROUND: Transient hyperprolactinemia was proven to adversely affect the outcome of IVF. We aimed to identify changes in serum prolactin levels in patients undergoing ICSI, and to evaluate the effect of these changes on the clinical pregnancy rate. METHODS: A prospective observational study included 90 patients scheduled for ICSI cycles. In each case 4 serum samples were collected during the cycle (midluteal, before ovum pick up procedure (OPU), 2 h after OPU, and before embryo transfer)...
May 9, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29737549/effect-of-pb-resistant-plant-growth-promoting-rhizobacteria-inoculation-on-growth-and-lead-uptake-by-lathyrus-sativus
#5
Souhir Abdelkrim, Salwa H Jebara, Omar Saadani, Manel Chiboub, Ghassen Abid, Moez Jebara
In search of efficient and resistant plant growth-promoting rhizobacteria (PGPR) strains with multiple activities, a total of twelve bacterial belonging to R. leguminosarum, S. meliloti, Pseudomonas sp., P. fluorescens, Luteibacter sp., Variovorax sp., B. simplex, and B. megaterium were isolated from root nodules of grass pea (Lathyrus sativus L.) grown in contaminated soils. Upon screening, all test strains were able to synthesize indoleacetic acid; more than 90% were siderophore producers and 75% showed varying levels of phosphate solubilizing ability...
May 8, 2018: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/29734825/skin-and-eye-irritation-assessment-of-oil-palm-elaeis-guineensis-leaf-extract-for-topical-application
#6
Nor Zuliana Yusof, Siti Salwa Abd Gani, Zafarizal Aldrin Azizul Hasan, Zainab Idris
Many types of phytochemicals have been found to be present in oil palm leaf and could potentially be used as functional ingredients for skincare product. However, as of today, there is no published report on hazard identification and safety assessment of oil palm ( Elaeis guineensis) leaf extract (OPLE), particularly on skin and eye irritation. In this study, potential hazard of OPLE on skin and eye irritation was evaluated as an initial step to the safety assessment of OPLE. In vitro cell viability study of OPLE on normal human dermal fibroblasts showed that OPLE was nontoxic to the cells with percentage viability more than 90% after 24 and 48 hours of incubation...
January 1, 2018: International Journal of Toxicology
https://www.readbyqxmd.com/read/29731925/serum-apelin-a-new-marker-of-early-atherosclerosis-in-children-with-type-1-diabetes-mellitus
#7
Rania N Sabry, Maged A El Wakeel, Ghada M El-Kassas, Ahmed F Amer, Wael H El Batal, Salwa Refat El-Zayat, Mohamed Abou-El-Asrar
INTRODUCTION: Type 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be complicated by micro or macrovascular complications. Measurement of the carotid intima-media thickness (CIMT) allows the early detection of atherosclerotic alterations of blood vessels that may complicate T1DM. SUBJECTS AND METHODS: This study is a case-control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731632/development-of-nanoemulsion-for-efficient-brain-parenteral-delivery-of-cefuroxime-designs-characterizations-and-pharmacokinetics
#8
Siti Norhawani Harun, Syafinaz Amin Nordin, Siti Salwa Abd Gani, Ahmad Fuad Shamsuddin, Mahiran Basri, Hamidon Bin Basri
Background and aim: Drugs that are effective against diseases in the central nervous system and reach the brain via blood must pass through the blood-brain barrier (BBB), a unique interface that protects against potential harmful molecules. This presents a major challenge in neuro-drug delivery. This study attempts to fabricate the cefuroxime-loaded nanoemulsion (CLN) to increase drug penetration into the brain when parenterally administered. Methods: The nanoemulsions were formulated using a high-pressure homogenization technique and were characterized for their physicochemical properties...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29729865/new-leadership-for-the-who-regional-office-for-the-eastern-mediterranean-exceptional-election-in-an-exceptional-time
#9
Samer Jabbour, Sameen Siddiqi, Rita Giacaman, Hani Serag, Jawad Al-Lawati, Amirhossein Takian, Habiba Ben Romdhane, Elsheikh Badr, Laith J Abu-Raddad, Aida Seif El-Dawla, Salwa Najjab, Driss Moussaoui, Mustafa Khogali, Yousef Khader, Bothaina Attal, Iman Nuwayhid
No abstract text is available yet for this article.
May 2, 2018: Lancet
https://www.readbyqxmd.com/read/29709235/-tunisian-national-protocol-for-adult-hodgkin-s-lymphoma-treatment-results-of-a-therapeutic-regimen-adapted-to-the-2-cycle-ct-response-about-444-patients
#10
Raihane Ben Lakhal, Sondos Hdiji, Sami Zriba, Amina Mokrani, Mohamed Adnen Laatiri, Yossra BenYoussef, Faten Ezzaier, Nabil Toumi, Salwa Ladeb, Hanen BenSalah, Sameh Tebra, Hatem Frikha, Taha Messai, Jamel Daoued, Noureddine Bouaouina, Monji Maalej, Mounir Frikha, Tarek BenOthmen, Slim BenAhmed, Abderrahim Khelif, Fehmi Msaddek, Amel Mezlini, Moez Elloumi, Balkis Meddeb
OBJECTIVE: In Tunisia, the management of Adult Hodgkin's Lymphoma (HL) has been standardized since 1999. We propose in this study to report the therapeutic results of the national protocol of adult HL treatment (MDH2008). PATIENTS AND METHODS: Our study is prospective multicenter interesting 444 patients followed for HL between July 2008 and June 2013 and treated according to the MDH2008 protocol. The median age of our patients was 30 years. B symptoms were present in 62...
April 27, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29695917/four-cycles-of-adriamycin-and-cyclophosphamide-followed-by-four-cycles-of-docetaxel-nsabp-b27-with-concomitant-trastuzumab-as-neoadjuvant-therapy-for-high-risk-early-stage-her2-positive-breast-cancer-patients
#11
Hikmat Abdel-Razeq, Salwa S Saadeh, Mahmoud Abu-Nasser, Hazem Abdulelah, Lina Marie, Murad Salam, Basel Al-Haj Ali, Mohammad Ibrahim, Dalia Rimawi
Background: The majority of breast cancer patients in Jordan are diagnosed at a young age and present with metastatic or locally advanced disease. The National Surgical Adjuvant Breast and Bowel Project Protocol B27 (NSABP-B27) (four cycles of adriamycin and cyclophosphamide [AC] followed by four cycles of docetaxel) is a standard neoadjuvant regimen in our institution. In this study, we report the efficacy of adding trastuzumab to docetaxel in this regimen for high-risk human epidermal growth factor receptor 2 (HER2)-positive early-stage disease...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29692247/synthesis-molecular-docking-and-dynamics-simulation-studies-of-new-7-oxycoumarin-derivatives-as-potential-antioxidant-agents
#12
Nehad Ahmed Abdel Latif, Rasha Zakaria Batran, Salwa F Mohamed, Mohamed A Khedr, Mohamed Kobeasy, Sara Al-Shehri, Hanem Awad
METHOD: Two new series of 4-styryl-7-oxycoumarin derivatives 3a-i and 4-styryl-7-oxycoumarin-8-Mannich bases 6a-r were designed and synthesized. Ten compounds were evaluated for their antioxidant activity in vitro against DPPH and in vivo against lipid peroxidation, superoxide dismutase (SOD), glutathione-s-transferase (GST) and catalase (CAT) activities. Molecular modeling study was performed to predict the mode of binding of the target compounds in the binding site. RESULTS & CONCLUSION: Although the tested compounds showed moderate to low dose dependent DPPH inhibition activities in vitro, most of them displayed remarkable antioxidant effects in vivo...
April 23, 2018: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29683094/role-of-inflammatory-markers-in-elderly-type-2-diabetic-patients-with-mild-cognitive-impairment
#13
Salwa S Hosny, Ahmed M Bahaaeldin, Mohamed S Khater, Meram M Bekhet, Hayam A Hebah, Ghada A Hasanin
BACKGROUND: Type 2 diabetes (T2DM) is a risk factor for Alzheimer's disease and mild cognitive impairment. The etiology of cognitive impairment in people with T2DM is uncertain but, chronic hyperglycemia, cerebral micro vascular disease, severe hypoglycemia, and increased prevalence of macro vascular disease are implicated. OBJECTIVES: to determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and highly sensitive C-reactive protein (hs-CRP) in elderly type 2 diabetics with mild cognitive impairment (MCI)...
April 22, 2018: Current Diabetes Reviews
https://www.readbyqxmd.com/read/29681822/mullerianosis-of-the-urinary-bladder-a-case-report
#14
Rawan Abdul Razack Amir, Khalid M Taheini, Salwa S Sheikh
Mullerianosis is a rare entity consisting of an admixture of 2 or more of the following tissues: endometriosis, endocervicosis, and endosalpingiosis. It most commonly affects the urinary bladder and affects females of fertile age. It presents clinically as hematuria, dysuria, and pelvic pain which may be associated with menstruation. Radiologically and macroscopically, it typically presents as a polypoid mass in the dome or posterior wall of the bladder. Histologically, it consists of glands of varying size lined by endometrial, endocervical, or tubal epithelium...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29659771/infectious-complications-after-deployment-trauma-following-wounded-united-states-military-personnel-into-veterans-affairs-care
#15
Jay R McDonald, Stephen Y Liang, Ping Li, Salwa Maalouf, Clinton K Murray, Amy C Weintrob, Elizabeth R Schnaubelt, Janis Kuhn, Anuradha Ganesan, William Bradley, David R Tribble
Background: Infectious complications related to deployment trauma significantly contribute to the morbidity and mortality impacting wounded service members. The Trauma Infectious Disease Outcomes Study (TIDOS) collects data on U.S. military personnel injured in Iraq and Afghanistan in an observational cohort study of infectious complications. Patients enrolled in TIDOS may also consent to follow-up through the Department of Veterans Affairs (VA). We present data from the first 337 TIDOS enrollees to receive VA healthcare...
April 6, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29627656/design-synthesis-and-evaluation-of-some-pyrazolo-3-4-d-pyrimidines-as-anti-inflammatory-agents
#16
Gina N Tageldin, Salwa M Fahmy, Hayam M Ashour, Mounir A Khalil, Rasha A Nassra, Ibrahim M Labouta
New pyrazolo[3,4-d]pyrimidines substituted with various functionalities or attached to a substituted pyrazole ring through different linkages were synthesized. The synthesized compounds were evaluated for their anti-inflammatory activity using in vitro COX-1/COX-2 inhibition assay and in vivo formalin induced paw edema and cotton pellet-induced granuloma assays. Results revealed that compounds 17b and 18 possessed COX-1/COX-2 selectivity indices higher than diclofenac sodium and celecoxib. However, compounds 16a,b exhibited selectivity indices higher than diclofenac sodium and nearly equivalent to celecoxib, whereas, 9b displayed selectivity index comparable to diclofenac sodium...
April 3, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29622963/role-of-2d-speckle-tracking-echocardiography-in-predicting-acute-coronary-occlusion-in-patients-with-non-st-segment-elevation-myocardial-infarction
#17
Viola William Keddeas, Salwa Mohammed Swelim, Ghada Kamel Selim
Background: A substantial fraction of patients with non ST-elevation acute coronary syndrome have an occluded culprit vessel on coronary angiography. Acute coronary occlusion often results in myocardial infarction and loss of systolic function. Identification of these patients may have considerable impact on treatment and prognosis. Aim: The study aims at investigating role of 2D speckle tracking echocardiography as a non-invasive predictor of acute coronary artery occlusion in patients with non ST-segment elevation myocardial infarction...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29611610/prevalence-of-skin-diseases-amongst-moroccan-fishermen
#18
Omar Laraqui, Nadia Manar, Salwa Laraqui, Tarik Ghailan, Frédéric Deschamps, Reda Hammouda, Chakib El Houssine Laraqui
BACKGROUND: The main objective was to evaluate the prevalence of skin diseases amongst fishermen, to specify the different clinical forms, associations and most frequent localisations, and to identify potential aetiological factors. The secondary objectives were to assess the knowledge, attitudes and practices of seafarers regarding occupational dermatoses to conduct information, awareness and education campaigns on risk factors and behaviours and to propose adapted prevention. MATERIALS AND METHODS: This cross-sectional survey involved 1102 artisanal fishermen who attended the annual legal medical consultation at the occupational health service...
2018: International Maritime Health
https://www.readbyqxmd.com/read/29611609/prevalence-of-chronic-obstructive-respiratory-diseases-amongst-fishermen
#19
Omar Laraqui, Reda Hammouda, Salwa Laraqui, Nadia Manar, Tarik Ghailan, Jaouda Ben Amor, Frédéric Deschamps, Chakib El Houssine Laraqui
BACKGROUND: The objective was to screen and evaluate the prevalence of respiratory diseases and obstructive ventilatory defects among fishermen in Morocco. MATERIALS AND METHODS: This observational and cross-sectional epidemiological study involved 924 men over 20 years old and with at least two years of seniority. It included a questionnaire and a spirometry. The questionnaire is composed of four sections: sociodemographic and occupational characteristics, toxic habits, medical history and respiratory clinical symptoms...
2018: International Maritime Health
https://www.readbyqxmd.com/read/29565312/development-of-phaleria-macrocarpa-scheff-boerl-fruits-using-response-surface-methodology-focused-on-phenolics-flavonoids-and-antioxidant-properties
#20
Khurul Ain Mohamed Mahzir, Siti Salwa Abd Gani, Uswatun Hasanah Zaidan, Mohd Izuan Effendi Halmi
In this study, the optimal conditions for the extraction of antioxidants from the Buah Mahkota Dewa fruit ( Phaleria macrocarpa) was determined by using Response Surface Methodology (RSM). The optimisation was applied using a Central Composite Design (CCD) to investigate the effect of three independent variables, namely extraction temperature (°C), extraction time (minutes) and extraction solvent to-feed ratio (% v / v ) on four responses: free radical scavenging activity (DPPH), ferric ion reducing power assay (FRAP), total phenolic content (TPC) and total flavonoid content (TFC)...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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