Hsin-Yi Chang, Josephine Dermawan, Aarti Sharma, Brendan Dickson, Gulisa Turashvili, Dianne Torrence, Marisa Nucci, Sarah Chiang, Esther Oliva, Martina Kirchner, Albrecht Stenzinger, Gunhild Mechtersheimer, Cristina Antonescu
RAD51B-rearranged sarcomas are rare neoplasms that exhibit a heterogeneous morphology. To date, 6 cases have been reported, all involving the uterus, including 4 perivascular epithelioid cell tumors (PEComas) and 2 leiomyosarcomas (LMS). In this study, we describe the morphologic, immunohistochemical, and molecular features of 8 additional sarcomas with RAD51B rearrangement, including the first extrauterine example. All patients were women with a median age of 57 years at presentation. Seven tumors originated in the uterus, and one in the lower extremity soft tissue, with a median tumor size of 12 cm...
February 2024: Modern Pathology