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Alexey Tsyganov, Jan Petru, Jan Skoda, Lucie Sediva, Pavel Hala, Jiri Weichet, Marek Janotka, Milan Chovanec, Petr Neuzil, Vivek Y Reddy
PURPOSE: We evaluated the correlation between pulmonary venous (PV) anatomy and acute and long-term success of PV isolation (PVI) with two balloon-based ablation catheter techniques. METHODS: One hundred consecutive patients were analyzed in two equal groups treated with either the second-generation cryoballoon (CRYO) catheter or the visually guided laser ablation (VGLA) catheter. All patients underwent multi-detector computed tomography (CT) imaging. The primary and secondary efficacy endpoints were the procedural achievement of proven electrical isolation of all veins and freedom from atrial fibrillation (AF) within a 1-year follow-up period, respectively...
December 2015: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Ekrem Üçer, Sabine Fredersdorf, Carsten Gerald Jungbauer, Joachim Seegers, Kurt Debl, Günter Riegger, Lars Siegfried Maier
AIMS: The isolation of the pulmonary veins (PVs) is the mainstay of atrial fibrillation (AF) ablation, which with current ablation techniques can be achieved in almost all cases. Reconnection of PVs constitutes the most frequent cause of AF recurrence. Visually guided laser balloon ablation (VGLA) is a novel system with very high rate of persistence of pulmonary vein isolation (PVI) three months after the first procedure shown in preclinical and clinical studies. We aimed to determine the acute efficiency of the laser energy during PVI with the help of adenosine provocation...
September 2015: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Lucie Šedivá, Jan Petrů, Jan Škoda, Marek Janotka, Milan Chovanec, Vivek Reddy, Petr Neužil
AIMS: Durable isolation of the pulmonary veins (PVs) remains the cornerstone of treatment for paroxysmal atrial fibrillation (PAF) and is also used in the treatment of some patients with persistent atrial fibrillation. Visually guided laser ablation (VGLA) has been proven to be safe and effective as a treatment for atrial fibrillation (AF). It has shown high levels of durable PV isolation (PVI), even in the hands of less experienced users. This paper presents the long-term clinical outcomes of all patients treated with VGLA over the course of 4 years in the world's most experienced centre: from early product feasibility work treating only PAF patients to our work using the commercially available product, when we also treated persistent AF patients...
December 2014: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Srinivas R Dukkipati, Karl-Heinz Kuck, Petr Neuzil, Ian Woollett, Josef Kautzner, H Thomas McElderry, Boris Schmidt, Edward P Gerstenfeld, Shephal K Doshi, Rodney Horton, Andreas Metzner, Andre d'Avila, Jeremy N Ruskin, Andrea Natale, Vivek Y Reddy
BACKGROUND: Because of the technical difficulty with achieving pulmonary vein (PV) isolation in the treatment of patients with paroxysmal atrial fibrillation, novel catheter designs to facilitate the procedure are in development. A visually guided laser ablation (VGLA) catheter was designed to allow the operator to directly visualize target tissue for ablation and then deliver laser energy to perform point-to-point circumferential ablation. Single-center studies have demonstrated favorable safety and efficacy...
June 2013: Circulation. Arrhythmia and Electrophysiology
Srinivas R Dukkipati, Petr Neuzil, Josef Kautzner, Jan Petru, Dan Wichterle, Jan Skoda, Robert Cihak, Petr Peichl, Antonio Dello Russo, Gemma Pelargonio, Claudio Tondo, Andrea Natale, Vivek Y Reddy
BACKGROUND: The visually guided laser ablation (VGLA) catheter is a compliant, variable-diameter balloon that delivers laser energy around the pulmonary vein (PV) ostium under real-time endoscopic visualization. While acute PV isolation has been shown to be feasible, limited data exist regarding the durability of isolation. OBJECTIVE: We sought to determine the durability of PV isolation following ablation using the balloon-based VGLA catheter. METHODS: The VGLA catheter was evaluated in patients with paroxysmal atrial fibrillation (3 sites, 10 operators)...
June 2012: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Susanne Brummelte, Ruth E Grunau, Anat Zaidman-Zait, Joanne Weinberg, David Nordstokke, Ivan L Cepeda
Cortisol levels were compared in children born preterm at extremely low gestational age (ELGA; 24-28 weeks), very low gestational age (VGLA; 29-32 weeks), and full-term in response to cognitive assessment at 18 months corrected age (CA). Further, we investigated the relationship between maternal interactive behaviors and child internalizing behaviors (rated by the mother) in relation to child cortisol levels. EGLA children had higher "pretest" cortisol levels and a different pattern of cortisol response to cognitive assessment compared to VGLA and full-terms...
March 2011: Developmental Psychobiology
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