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https://www.readbyqxmd.com/read/29793090/anti-haemostatic-compounds-from-the-vampire-snail-cumia-reticulata-molecular-cloning-and-in-silico-structure-function-analysis
#1
Maria Vittoria Modica, Jonathan Reinoso Sánchez, Andrea Pasquadibisceglie, Marco Oliverio, Paolo Mariottini, Manuela Cervelli
Blood-feeding animals are known for their ability to produce bioactive compounds to impair haemostasis and suppress pain perception in the host. These compounds are extremely appealing for pharmacological development since they are generally very effective and specific for their molecular target. A preliminary RNA-Seq based characterization of the secretion from salivary and mid-oesophageal tissues of the vampire snail Cumia reticulata, revealed a complex mixture of feeding-related transcripts with potential anaesthetic and anticoagulant action...
May 16, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29793051/promising-antileishmanial-activity-of-novel-imidazole-antifungal-drug-luliconazole-against-leishmania-major-in-vitro-and-in-silico-studies
#2
Azar Shokri, Mahdi Abastabar, Masoud Keighobadi, Saeed Emami, Mahdi Fakhar, Saeed Hosseini Teshnizi, Koichi Makimura, Ali Rezaei-Matehkolaei, Hassan Mirzaei
OBJECTIVES: Pentavalent antimonials have been used for the treatment of leishmaniasis for more than 70 years; however their toxicity limits their benefits. Unfortunately, the efficacy of the first line drugs has been decreased and resistance seems to be noticeable. Luliconazole is a new azole with unique effects on fungi which has not been tested on Leishmania parasites yet. METHODS: In the present study, we evaluated cytotoxicity and anti-leishmanial activities of Luliconazole on promastigotes and intracellular amastigotes of Leishmania major (L...
May 21, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29792975/bladder-agenesis-and-associated-pelvic-arterial-anomaly-in-two-female-pediatric-patients
#3
Thomas Lowrey, Shellie Josephs, Linda A Baker
Bladder agenesis is an extremely rare congenital anomaly of the genitourinary tract. Two female patients with known diagnoses of bladder agenesis presented for pre-renal transplant evaluation and neobladder creation. Similar unique pelvic arterial malformations were identified through pre-operative imaging and intraoperative examination. With these similar findings, it could be proposed that such anatomical variants are products of the same insult or involve a causal relationship, with vascular aberrancies potentially provoking pelvic organ maldevelopment...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792837/total-avulsed-ear-management-with-radial-forearm-free-flap
#4
Uzair Luqman, Zahid Qayyum, Zahid Furqan, Kaleem Ullah
Avulsive injuries to the ear are extremely challenging to treat. The literature documents numerous ways to manage such injuries. This report describes a case of total auricular cartilaginous avulsion that occurred during a motor vehicle accident. The avulsed segment had an ischemia time longer than 8 hours by the time of presentation at the authors' tertiary care facility. The avulsed segment was de-epithelialized and embedded into the volar forearm. After a healing period of 6 months, a radial forearm free flap was harvested and the ear was reconstructed...
April 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29792755/dalangtan-saline-playa-in-a-hyperarid-region-on-tibet-plateau-i-evolution-and-environments
#5
Fanjing Kong, Mianping Zheng, Bin Hu, Alian Wang, Nina Ma, Pablo Sobron
Since 2008, we have been studying a saline lake, Dalangtan (DLT) Playa, and its surroundings in a hyperarid region of the Qaidam Basin on the Tibetan Plateau as a potential Mars analog site. We describe the evolution of saline deposits in the Qaidam Basin (including DLT), based on investigative findings accumulated over the course of 60 years of geological surveys. In addition, we report regional meteorological patterns recorded for the past 32 years along with meteorological station recorded data at DLT since 2012...
May 24, 2018: Astrobiology
https://www.readbyqxmd.com/read/29792734/clinical-updates-on-perianal-fistulas-in-crohn-s-disease
#6
Ori Rackovsky, Robert Hirten, Ryan Ungaro, Jean-Frederic Colombel
Perianal fistulizing disease is an aggressive and debilitating phenotype of Crohn's disease (CD), representing a significant therapeutic challenge. New work has led to advancement in epidemiology and long term outcomes of perianal disease. The range of therapeutic options continues to expand, including new biologic agents, biosimilars, and stem cell therapy. Areas covered: We discuss updates to all aspects of management of perianal disease, with a focus on the last three years of published data. Areas considered include new data on epidemiology and prognostication, medical and surgical therapy, and stem cell therapy...
May 24, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29792725/novel-breast-imaging-and-machine-learning-predicting-breast-lesion-malignancy-at-cone-beam-ct-using-machine-learning-techniques
#7
Johannes Uhlig, Annemarie Uhlig, Meike Kunze, Tim Beissbarth, Uwe Fischer, Joachim Lotz, Susanne Wienbeck
OBJECTIVE: The purpose of this study is to evaluate the diagnostic performance of machine learning techniques for malignancy prediction at breast cone-beam CT (CBCT) and to compare them to human readers. SUBJECTS AND METHODS: Five machine learning techniques, including random forests, back propagation neural networks (BPN), extreme learning machines, support vector machines, and K-nearest neighbors, were used to train diagnostic models on a clinical breast CBCT dataset with internal validation by repeated 10-fold cross-validation...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792707/nano-scale-conductive-filament-with-alternating-rectification-as-an-artificial-synapse-building-block
#8
Dan Berco, Yu Zhou, Sankara Rao Gollu, Pranav Sairam Kalaga, Abhisek Kole, Mohamed Hassan, Diing Shenp Ang
A popular approach for resistive memory (RRAM) based hardware implementation of neural networks utilizes one (or two) device that functions as an analog synapse in a crossbar structure of perpendicular pre- and post-synaptic neurons. An ideal fully automated, large scale artificial neural network, that matches a biologic counterpart (in terms of density and energy consumption), thus requires nano sized, extremely low power devices with a wide dynamic range and multi level functionality. Unfortunately the tradeoff between these traits proves to be a serious obstacle in the realization of brain inspired computing platforms yet to be overcome...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792676/dramatic-increase-in-polymer-glass-transition-temperature-under-extreme-nanoconfinement-in-weakly-interacting-nanoparticle-films
#9
Haonan Wang, Jyo Lyn Hor, Yue Zhang, Tianyi Liu, Daeyeon Lee, Zahra Fakhraai
Properties of polymers in polymer nanocomposites and nanopores have been shown to deviate from their respective bulk properties due to chain confinement as well as polymer-particle interfacial interactions. However, separating the confinement effects from the interfacial effects under extreme nanoconfinement is experimentally challenging. Capillary Rise Infiltration (CaRI) enables polymer infiltration into nanoparticle (NP) packings, thereby confining polymers within extremely small pores and dramatically increasing the interfacial area, providing a unique system to systematically distinguish the role of each effect on polymer properties...
May 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29792468/teamwork-and-collaboration-in-long-duration-space-missions-going-to-extremes
#10
Lauren Blackwell Landon, Kelley J Slack, Jamie D Barrett
The scientific study of teamwork in the context of spaceflight has uncovered a considerable amount of knowledge over the past 20 years. Although much is known about the underlying factors and processes of teamwork, much is left to be discovered for teams who will be operating in extreme isolation and confinement during a future Mars mission. Special considerations must be made to enhance teamwork and team well-being for multi-year missions during which the small team will live and work together. We discuss the unique challenges of effective teamwork in a Mars mission scenario, and the difficulties of studying teamwork using analogs of the space environment...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792462/extreme-teams-toward-a-greater-understanding-of-multiagency-teamwork-during-major-emergencies-and-disasters
#11
Nicola Power
Major emergencies are extreme team decision making environments. They are complex, dynamic, high-stakes and fast paced events, wherein successful resolution is contingent upon effective teamwork. Not only do emergency teams coordinate at the intrateam level (e.g., police team), but they are increasingly required to operate at the interteam level (e.g., police, fire and ambulance teams). This is in response to the desire for networked and cost-effective practice and due to the evolving nature of modern threats, such as extreme weather events and terrorist attacks, which require a multi- rather than single-agency response...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792253/genocide-rape-trauma-a-conceptual-framework-for-understanding-the-psychological-suffering-of-rwandan-survivors
#12
Donatilla Mukamana, Anthony Collins, William E Rosa
In 1994, the Rwandan genocide claimed the lives of approximately 1 million Tutsi and moderate Hutu citizens. Systematic rape was a strategic component of the Hutu extremist plan to eradicate the Tutsi minority population. This involved collective and repeated sexual assaults with brutal violence, public humiliation, and torture. This article maps the ongoing psychological impact on Rwandan genocide rape survivors and identifies implications for international nursing practice. The research formalizes their narratives, identifying a number of interconnected elements that combine to produce myriad forms of chronic psychological suffering in the Rwandan context...
May 1, 2018: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/29792248/metataxonomic-analysis-of-individuals-at-bmi-extremes-and-monozygotic-twins-discordant-for-bmi
#13
Casey T Finnicum, Stieneke Doornweerd, Conor V Dolan, Justin M Luningham, Jeffrey J Beck, Gonneke Willemsen, Erik A Ehli, Dorret I Boomsma, Richard G Ijzerman, Gareth E Davies, Eco J C de Geus
OBJECTIVE: The human gut microbiota has been demonstrated to be associated with a number of host phenotypes, including obesity and a number of obesity-associated phenotypes. This study is aimed at further understanding and describing the relationship between the gut microbiota and obesity-associated measurements obtained from human participants. SUBJECTS/METHODS: Here, we utilize genetically informative study designs, including a four-corners design (extremes of genetic risk for BMI and of observed BMI; N = 50) and the BMI monozygotic (MZ) discordant twin pair design (N = 30), in order to help delineate the role of host genetics and the gut microbiota in the development of obesity...
June 2018: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/29792178/anti-ganglioside-complex-antibody-profiles-in-a-recurrent-complicated-case-of-gq1b-seronegative-miller-fisher-syndrome-and-bickerstaff-brainstem-encephalitis-a-case-report
#14
Hiroto Ito, Yuki Hatanaka, Yuki Fukami, Yumiko Harada, Rei Kobayashi, Hisashi Okada, Ayumi Uchibori, Atsuro Chiba, Satoshi Okuda
BACKGROUND: Guillain-Barré syndrome (GBS), Miller Fisher syndrome (MFS) and Bickerstaff brainstem encephalitis (BBE) are a group of autoimmune neurological disorders (GBS spectrum disorder) that rarely recur. Recently, anti-ganglioside complex antibodies (GSC-Abs) were identified in patients with GBS spectrum disorder. However, there has been no case report describing GSC-Abs profiles in a recurrent case showing different phenotypes. CASE PRESENTATION: We report the case of a 33-year-old male patient with GQ1b-seronegative BBE-GBS after two prior episodes of MFS-GBS...
May 23, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29792170/liddle-s-like-syndrome-associated-with-nephrotic-syndrome-secondary-to-membranous-nephropathy-the-first-case-report
#15
Eriko Yamaguchi, Kazuhiro Yoshikawa, Izaya Nakaya, Karen Kato, Yoshikazu Miyasato, Terumasa Nakagawa, Yutaka Kakizoe, Masashi Mukoyama, Jun Soma
BACKGROUND: Liddle's syndrome is a rare monogenic form of hypertension caused by truncating or missense mutations in the C termini of the epithelial sodium channel (ENaC) β or γ subunits. Patients with this syndrome present with early onset of hypertension, hypokalemia, metabolic alkalosis, hyporeninemia and hypoaldosteronism, and a potassium-sparing diuretics (triamterene or amiloride) can drastically improves the disease condition. Although elderly patients having these characteristics were considered to have Liddle's syndrome or Liddle's-like syndrome, no previous report has indicated that Liddle's-like syndrome could be caused by nephrotic syndrome of primary glomerular disease, which is characterized by urinary excretion of > 3 g of protein/day plus edema and hypoalbuminemia, or has explained how the activity function of ENaC could be affected in the setting of high proteinuria...
May 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29792168/trends-in-the-incidence-and-associated-factors-of-late-onset-sepsis-associated-with-improved-survival-in-extremely-preterm-infants-born-at-23-26-weeks-gestation-a-retrospective-study
#16
Jin Kyu Kim, Yun Sil Chang, Sein Sung, So Yoon Ahn, Won Soon Park
BACKGROUND: To investigate the trends in the incidence and associated factors of late-onset sepsis (LOS) associated with improved survival in extremely preterm infants. METHODS: Medical records of 364 infants who were born at 23-26 weeks' gestation from 2000 to 2005 (period I, n = 124) and from 2006 to 2011 (period II, n = 240) were retrospectively reviewed. The infants were stratified into subgroups of 23-24 and 25-26 weeks' gestation within each period, and survival, LOS rate, and clinical characteristics were analyzed...
May 23, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29792108/does-maximalist-footwear-lower-impact-loading-during-level-ground-and-downhill-running
#17
Zoe Y S Chan, Ivan P H Au, Fannie O Y Lau, Eric C K Ching, Janet H Zhang, Roy T H Cheung
A new model of running shoes which features an extreme cushioning and an oversized midsole, known as the maximalist (MAX) was launched. This design claims to provide excellent shock absorption, particularly during downhill running. This study sought to assess the effects of MAX on the external impact loading, footstrike pattern, and stride length during level ground and downhill running on an instrumented treadmill. Twenty-seven distance runners completed four 5-minute running trials in the two footwear conditions (MAX and traditional running shoes (TRS)) on a level surface (0%) and downhill (10%-declination)...
May 24, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29792071/phosphoramidates-and-phosphonamidates-protides-with-antiviral-activity
#18
Magdalena Slusarczyk, Michaela Serpi, Fabrizio Pertusati
Following the first report on the nucleoside phosphoramidate (ProTide) prodrug approach in 1990 by Chris McGuigan, the extensive investigation of ProTide technology has begun in many laboratories. Designed with aim to overcome limitations and the key resistance mechanisms associated with nucleoside analogues used in the clinic (poor cellular uptake, poor conversion to the 5'-monophosphate form), the ProTide approach has been successfully applied to a vast number of nucleoside analogues with antiviral and anticancer activity...
January 2018: Antiviral Chemistry & Chemotherapy
https://www.readbyqxmd.com/read/29791988/-liver-abscess-secondary-to-perforation-after-duodenal-endoscopic-resection
#19
Seung Ho Choi, Su Jin Kim, Dae Hwan Kang, Hyung Wook Kim, Cheol Woong Choi, Tae Un Kim, Jeong Seok Lee, Ji Hwan Ko
Duodenal perforation is a complication of endoscopic mucosal resection. Liver abscess secondary to iatrogenic perforation is extremely rare. A 43-year-old female visited the hospital to remove a sub-epithelial tumor on the duodenal bulb. After endoscopic mucosal resection with band ligation, duodenal perforation occurred. Endoscopic closure was performed successfully using a clipping device to manage duodenal perforation. After 4 weeks, the patient visited our outpatient clinic due to abdominal pain and fever...
May 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29791962/nerve-entrapment-syndromes-at-the-wrist-and-elbow-by-sonography
#20
Andrea S Klauser, Tommaso Buzzegoli, Mihra S Taljanovic, Sylvia Strobl, Stefan Rauch, James Teh, Julia Wanschitz, Wolfgang Löscher, Carlo Martinoli
Nerve entrapment syndromes of the upper extremity are associated with structural abnormalities or by an intrinsic abnormality of the nerve. Nerve entrapment syndromes generally have a typical clinical presentation, and findings on physical examination and in conjunction with electrodiagnostic studies imaging is used to evaluate the cause, severity, and etiology of the entrapment. With the development of high-frequency linear array transducers (12-24 MHz), ultrasound (US) is incomparable in terms of spatial resolution to depict morphological aspects and changes in nerves...
July 2018: Seminars in Musculoskeletal Radiology
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