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https://www.readbyqxmd.com/read/28922839/first-description-of-a-new-uncultured-epsilon-sulfur-bacterium-colonizing-marine-mangrove-sediment-in-the-caribbean-thiovulum-sp-strain-karukerense
#1
Olivier Gros
Here, the first description is reported of an epsilon sulfur-oxidizing bacterium from sulfide-rich sediments of marine mangrove in the Caribbean. By transition electron microscopy it was shown that this new strain contains intracytoplasmic large internal sulfur granules, which was confirmed by energy-dispersive X-ray spectroscopy analyses performed using an environmental scanning electron microscope. The sulfur distribution obtained for this sulfur-oxidizing bacterial strain allowed us to conclude that elemental sulfur is formed as an intermediate oxidation product and stored intracellularly...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28922838/comparative-genomics-of-a-drug-resistant-pseudomonas-aeruginosa-panel-and-the-challenges-of-antimicrobial-resistance-prediction-from-genomes
#2
J Jeukens, I Kukavica-Ibrulj, J G Emond-Rheault, L Freschi, R C Levesque
Antimicrobial resistance (AMR) is now recognized as a global threat to human health. The accessibility of microbial whole-genome sequencing offers an invaluable opportunity for resistance surveillance via the resistome, i.e. the genes and mutations underlying AMR. Unfortunately, AMR prediction from genomic data remains extremely challenging, especially for species with a large pan-genome. One such organism, for which multidrug-resistant (MDR) isolates are frequently encountered in the clinic, is Pseudomonas aeruginosa...
October 2, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28922704/direct-acting-antivirals-for-chronic-hepatitis-c
#3
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs), e.g. sofosbuvir, are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). Sustained virological response (SVR) is used by investigators and regulatory agencies as a surrogate outcome for morbidity and mortality, based solely on observational evidence...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922607/antdas-automatic-data-analysis-strategy-for-uplc-qtof-based-nontargeted-metabolic-profiling-analysis
#4
Hai-Yan Fu, Xiao-Ming Guo, Yue-Ming Zhang, Jing-Jing Song, Qing-Xia Zheng, Ping-Ping Liu, Peng Lu, Qian-Si Chen, Yong-Jie Yu, Yuanbin She
High-quality data analysis methodology remains a bottleneck for metabolic profiling analysis based on ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. The present work aims to address this problem by proposing a novel data analysis strategy wherein (1) chromatographic peaks in the UPLC-QTOF dataset are automatically extracted by using an advanced multiscale Gaussian smoothing-based peak extraction strategy. (2) A peak annotation stage is used to cluster fragment ions that belong to the same compound...
September 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28922585/climatic-and-anthropogenic-drivers-of-northern-amazon-fires-during-the-2015-2016-el-ni%C3%A3-o-event
#5
Marisa G Fonseca, Liana O Anderson, Egidio Arai, Yosio E Shimabukuro, Haron A M Xaud, Maristela R Xaud, Nima Madani, Fabien H Wagner, Luiz E O C Aragão
The strong El Niño Southern Oscillation (ENSO) event that occurred in 2015/2016 caused extreme drought in the northern Brazilian Amazon, especially in the state of Roraima, increasing fire occurrence. Here we map the extent of precipitation and fire anomalies and quantify the effects of climatic and anthropogenic drivers on fire occurrence during the 2015/2016 dry season (from December 2015 to March 2016) in the state of Roraima. To achieve these objectives we first estimated the spatial pattern of precipitation anomalies, based on long-term data from the TRMM (Tropical Rainfall Measuring Mission), and the fire anomaly, based on MODIS (Moderate Resolution Imaging Spectroradiometer) active fire detections during the referred period...
September 18, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28922555/laser-micro-ablation-of-fibrocartilage-tissue-effects-of-tissue-processing-on-porosity-modification-and-mechanics
#6
A M Matuska, P S McFetridge
The temporomandibular joint disk (TMJd) is an extremely dense and avascular fibrocartilaginous extracellular matrix (ECM) resulting in a limited regenerative capacity. The use of decellularized TMJd as a biocompatible scaffold to guide tissue regeneration is restricted by innate subcellular porosity of the ECM that hinders cellular infiltration and regenerative events. Incorporation of an artificial microporosity through laser micro-ablation (LMA) can alleviate these cell and diffusion based limitations. In this study, LMA was performed either before or after decellularization to assess to effect of surfactant treatment on porosity modification as well as the resultant mechanical and physical scaffold properties...
September 18, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28922520/a-review-of-joint-attention-and-social-cognitive-brain-systems-in-typical-development-and-autism-spectrum-disorder
#7
Peter Mundy
This article provides a review of the increasingly detailed literature on the neurodevelopment of joint attention. Many findings from this literature support and inform the hypothesis that the neurodevelopment of joint attention contributes to the functional development of neural systems for human social cognition. Joint attention begins to develop by 5 months of age and is tantamount to the ability to adopt a common perspective with another person. It involves a whole-brain system with nodes in the: (a) dorsal and medial frontal cortex, (b) orbital frontal/insula cortex, (c) anterior/ posterior cingulate cortex, (d) superior temporal cortex, (e) precuneus/parietal cortex, and (f) amygdala and striatum...
September 18, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28922505/enhancing-the-antimicrobial-activity-of-alamethicin-f50-5-by-incorporating-n-terminal-hydrophobic-triazole-substituents
#8
Sanjit Das, Khoubaib Ben Haj Salah, Emmanuel Wenger, Jean Martinez, Jules Kotarba, Vanessa Andreu, Nicolas Ruiz, Filippo Savini, Lorenzo Stella, Claude Didierjean, Baptiste Legrand, Nicolas Inguimbert
We propose a simple and efficient strategy to significantly improve the antibacterial activity of peptaibols and other antimicrobial peptides by N-terminal capping with 1,2,3-triazole bearing various hydrophobic substituents on C-4. We showed, herein, that such N-terminal insertions on alamethicin F50/5 could enhance its antimicrobial activity on gram-positive bacteria without modification of its overall three-dimensional structure. Indeed, while the native peptide and its analogues shared comparable helical contents, the crystal structure of one of the most active derivative showed a local slight distortion of the N-terminal extremity, which was also observed in solution using NMR spectroscopy...
September 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28922443/primary-hepatic-lymphoma-complicated-by-a-hepatic-inflammatory-pseudotumor-and-tumor-forming-pancreatitis
#9
Rena Kaneko, Hiroyuki Mitomi, Natsuko Nakazaki, Yuichiro Yano, Masazumi Ogawa, Yuzuru Sato
BACKGROUND: Hepatic inflammatory pseudotumor (IPT) is considered to be benign in biological behavior, and its malignant transformation is extremely rare. There has only been one published case of primary hepatic lymphoma complicated by hepatic IPT. CASE PRESENTATION: A 73-year-old man presented with obstructive jaundice and a pancreatic head mass. Histology of the mass revealed chronic pancreatitis with lymphoid follicle formation, leading to a diagnosis of a suspicion of follicular pancreatitis...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28922322/-vectra-3d-imaging-for-quantitative-volumetric-analysis-of-the-upper-limb-a-feasibility-study-for-tracking-outcomes-of-lymphedema-treatment
#10
Mark J Landau, Jennifer S Kim, Daniel J Gould, Ketan M Patel
BACKGROUND: Secondary lymphedema of the upper limb is a common sequela following lymphadenectomy during oncologic surgery. The gold standard for evaluating treatment outcomes in upper limb lymphedema is limb volume measurement. However, current techniques lack sensitivity to localized changes. In this study, the Vectra 3D imaging system was utilized to accurately and precisely obtain volume measurements of the upper limb in patients with lymphedema. METHODS: A feasibility study was performed in 11 patients with lymphedema and 22 upper extremities; 24 arms were evaluated in total...
September 14, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28922282/the-grind-project-get-ready-to-initiate-a-nursing-degree
#11
Philisie Starling Washington
Numbers of students who declare a prenursing major and who enter a nursing program are vastly different. The GRIND (Get Ready to Initiate a Nursing Degree) research project, which operated for 3-week sessions from 2011 to 2015, exposed students to the nursing career through hospital tours and human simulation while instructing in study skills, dosage calculation, and standardized test preparation. Participants' understanding of nursing improved, and most felt at least somewhat to extremely prepared for nursing after participation...
September 15, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/28922110/an-automated-system-for-the-detection-and-classification-of-retinal-changes-due-to-red-lesions-in-longitudinal-fundus-images
#12
Kedir M Adal, Peter G van Etten, Jose P Martinez, Kenneth W Rouwen, Koenraad A Vermeer, Lucas J van Vliet
People with diabetes mellitus need annual screening to check for the development of diabetic retinopathy. Tracking small retinal changes due to early diabetic retinopathy lesions in longitudinal fundus image sets is challenging due to intra- and inter-visit variability in illumination and image quality, the required high registration accuracy, and the subtle appearance of retinal lesions compared to other retinal features. This paper presents a robust and flexible approach for automated detection of longitudinal retinal changes due to small red lesions by exploiting normalized fundus images that significantly reduce illumination variations and improve the contrast of small retinal features...
September 15, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28922081/clinical-outcomes-following-conservative-management-of-chronic-traumatic-cervical-myelopathy-a-case-report
#13
Justin Bridges, Roberto Sandoval
BACKGROUND AND PURPOSE: There is limited evidence supporting the conservative management of patients with cervical myelopathy. The purpose of this report is to describe the intervention and outcomes of conservative physical therapy interventions for one patient with chronic cervical myelopathy. CASE DESCRIPTION: This case was a 50-year-old male who sustained a neck injury following a rear-end collision 4 years prior to this therapeutic episode. The patient presented with decreased range of motion in the cervical spine and right upper extremity, strength deficits, altered sensation, poor posture, and reported chronic cervical region pain and difficulty sleeping...
September 18, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28921939/extreme-hepatic-resections-for-the-treatment-of-advanced-hepatoblastoma-are-planned-close-margins-an-acceptable-approach
#14
Adriana Fonseca, Abha Gupta, Furqan Shaikh, Raveena Ramphal, Vicky Ng, Ian McGilvray, J Ted Gerstle
BACKGROUND: Orthotopic liver transplantation (OLT) is considered the standard for children with hepatoblastoma (HB) in whom complete surgical resection is not possible. However, OLT is not always available or feasible. OBJECTIVE: To describe the outcome of children with HB who were initially deemed unresectable and underwent complex hepatectomy with planned close margins, and ultimately avoided OLT. METHODS: Demographic data, surgical and pathologic details, and survival information were collected from children treated for HB between January 2010 to December 2015...
September 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28921813/what-is-the-safest-mode-of-birth-for-extremely-preterm-breech-singleton-infants-who-are-actively-resuscitated-a-systematic-review-and-meta-analyses
#15
Marinela Grabovac, Jehan N Karim, Tetsuya Isayama, Sugee Korale Liyanage, Sarah D McDonald
BACKGROUND: The safest delivery mode of extremely preterm breech singletons is unknown. OBJECTIVES: To determine safest delivery mode of actively resuscitated extremely preterm breech singletons. SEARCH STRATEGY: We searched Cochrane CENTRAL, MEDLINE, EMBASE, CINAHL and ClinicalTrials. gov from 1994-May 2017. SELECTION CRITERIA: We included studies comparing outcomes by delivery mode in actively resuscitated breech infants between 23(+0) -27(+6) weeks...
September 18, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28921750/successful-treatment-with-intrauterine-delivery-of-dexamethasone-for-repeated-implantation-failure
#16
Tao Zhang, Chunyu Huang, Yan Du, Ruochun Lian, Meilan Mo, Yong Zeng, Gil Mor
PROBLEM: Effective therapy for endometrial receptivity of patients with repeated embryo implantation failure (RIF) is far undeveloped. Whether intrauterine perfusion of dexamethasone (DXM), local administration of drugs with less systematic side-effects, benefit for embryo implantation by suppressing uterine NK (uNK) cells to improve endometrial receptivity remains unknown. METHOD OF STUDY: Women with RIF were analyzed for the correlation between the percentage of uNK cells during implantation window and following clinical pregnancy rate to determine the appropriate range of uNK for embryo implantation...
September 16, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28921657/reporting-anxiety-symptoms-in-extremely-preterm-born-adolescents-and-by-their-mothers
#17
M J Sømhovd, B H Esbjørn, B M Hansen, G Greisen
AIM: To compare anxiety symptoms in adolescents born extremely prematurely to term-born controls. METHODS: We had 96 preterm-born adolescents and 40 term-born controls from Denmark and their mothers score the adolescents on the Revised Children Anxiety and Depression scale. We analysed group differences, cross-informant correlations, and relative risks for elevated anxiety symptoms. RESULTS: Self-reported anxiety symptoms did not significantly differ, although the upper confidence limit (95% CI [-3...
September 16, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28921506/neurologic-injury-and-patient-displacement-in-gynecologic-laparoscopic-surgery-using-a-beanbag-and-shoulder-supports
#18
Alejandro D Treszezamsky, Suzanne Fenske, Erin L Moshier, Charles J Ascher-Walsh
OBJECTIVE: To quantify the incidence of peripheral neuropathy in gynecologic laparoscopic surgery using a combination of beanbag, eggcrate foam, and shoulder supports; and to assess patient displacement during surgery in a steep Trendelenburg position and determine variables correlated with displacement. METHODS: A retrospective study included all gynecologic laparoscopic surgeries performed by one high-volume surgeon at a US center between September 15, 2007, and September 15, 2012...
September 16, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28921474/origins-of-phantom-limb-pain
#19
Damien P Kuffler
Phantom limb pain (PLP) is a chronic neuropathic pain occurring in 45-85% of patients who undergo major amputations of the upper and lower extremities. Chronic pain is physically and mentally debilitating, affecting an individual's potential for self-care and the performance of daily living activities essential for personal and economic independence. In addition, chronic pain may lead to depression and feelings of hopelessness. A National Center for Biotechnology Information study found that in the USA alone, the annual cost of dealing with neuropathic pain is more than $600 billion, with an estimated 20 million people in the USA suffering this condition...
September 18, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28921440/microplate-based-method-for-high-throughput-screening-hts-of-chromatographic-conditions-studies-for-recombinant-protein-purification
#20
Rimenys J Carvalho, Thayana A Cruz
High-throughput screening (HTS) systems have emerged as important tools to provide fast and low cost evaluation of several conditions at once since it requires small quantities of material and sample volumes. These characteristics are extremely valuable for experiments with large number of variables enabling the application of design of experiments (DoE) strategies or simple experimental planning approaches. Once, the capacity of HTS systems to mimic chromatographic purification steps was established, several studies were performed successfully including scale down purification...
2018: Methods in Molecular Biology
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