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https://www.readbyqxmd.com/read/29352750/histomorphological-analysis-of-the-variability-of-the-human-skeleton-forensic-implications
#1
Marco Cummaudo, Annalisa Cappella, Miranda Biraghi, Caterina Raffone, Nicholas Màrquez-Grant, Cristina Cattaneo
One of the fundamental questions in forensic medicine and anthropology is whether or not a bone or bone fragment is human. Surprisingly at times for the extreme degradation of the bone (charred, old), DNA cannot be successfully performed and one must turn to other methods. Histological analysis at times can be proposed. However, the variability of a single human skeleton has never been tested. Forty-nine thin sections of long, flat, irregular and short bones were obtained from a well-preserved medieval adult human skeleton...
January 20, 2018: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29352683/discharge-to-inpatient-rehab-does-not-result-in-improved-functional-outcomes-following-primary-total-knee-arthroplasty
#2
Douglas E Padgett, Alexander B Christ, Amethia D Joseph, You-Yu Lee, Stephen B Haas, Stephen Lyman
BACKGROUND: Monitored rehabilitation has long been considered an essential part of the recovery process in total knee arthroplasty (TKA). However, the optimal setting for rehabilitation remains uncertain. We sought to determine whether inpatient rehabilitation settings result in improved functional and patient-reported outcomes after primary TKA. METHODS: All patients undergoing primary TKA from May 2007 to February 2011 were identified from our institutional total joint registry...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352678/e-bike-related-trauma-in-children-and-adults
#3
Itai Gross, Daniel J Weiss, Elior Eliasi, Miklosh Bala, Saar Hashavya
BACKGROUND: Electric bike (e-bike) usage is growing worldwide, and so is the e-bike-related injury rate. OBJECTIVE: This study was undertaken to characterize e-bike-related injuries. METHODS: Data of all e-bike-related injuries presenting to our level I trauma center between 2014 and 2016 were collected and analyzed. Adult and pediatric (<18 years of age) e-bike-related injuries were then analyzed separately and compared. RESULTS: Forty-eight patients suffering from e-bike-related injuries presented to our trauma center between January 1, 2014 and December 31, 2016...
January 15, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29352655/legume-consumption-and-risk-of-all-cause-cardiovascular-and-cancer-mortality-in-the-predimed-study
#4
Christopher Papandreou, Nerea Becerra-Tomás, Mònica Bulló, Miguel Ángel Martínez-González, Dolores Corella, Ramon Estruch, Emilio Ros, Fernando Arós, Helmut Schroder, Montserrat Fitó, Lluís Serra-Majem, José Lapetra, Miquel Fiol, Miguel Ruiz-Canela, Jose V Sorli, Jordi Salas-Salvadó
BACKGROUND & AIMS: Limited prospective studies have examined the association between legumes consumption and mortality, whereas scarce, if at all, previous studies have evaluated such associations taking into consideration specific grain legumes. We aimed to investigate the association between total legumes consumption and grain legumes species (dry beans, chickpeas, lentils, and fresh peas) with all-cause, cardiovascular disease (CVD), cancer and other-cause mortality among elderly Mediterranean individuals at high CVD risk...
January 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29352511/draft-genome-and-reference-transcriptomic-resources-for-the-urticating-pine-defoliator-thaumetopoea-pityocampa-lepidoptera-notodontidae
#5
B Gschloessl, F Dorkeld, H Berges, G Beydon, O Bouchez, M Branco, A Bretaudeau, C Burban, E Dubois, P Gauthier, E Lhuillier, J Nichols, S Nidelet, S Rocha, L Sauné, R Streiff, M Gautier, C Kerdelhué
The pine processionary moth Thaumetopoea pityocampa (Lepidoptera: Notodontidae) is the main pine defoliator in the Mediterranean region. Its urticating larvae cause severe human and animal health concerns in the invaded areas. This species shows a high phenotypic variability for various traits, such as phenology, fecundity, and tolerance to extreme temperatures. This study presents the construction and analysis of extensive genomic and transcriptomic resources, which are an obligate prerequisite to understand their underlying genetic architecture...
January 20, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29352482/influence-of-pharmacogenetic-polymorphisms-and-demographic-variables-on-metformin-pharmacokinetics-in-an-admixed-brazilian-cohort
#6
Ana Beatriz Santoro, Mariana Rodrigues Botton, Claudio José Struchiner, Guilherme Suarez-Kurtz
AIM: To identify pharmacogenetic and demographic variables that influence the systemic exposure to metformin in an admixed Brazilian cohort. METHODS: The extreme discordant phenotype was used to select 106 data sets from nine metformin bioequivalence trials, comprising 256 healthy adults. Eleven single-nucleotide polymorphisms in SLC22A1, SLC22A2, SLC47A1 SLC47A2 and in transcription factor SP1 were genotyped and a validated panel of ancestry informative markers was used to estimate the individual proportions of biogeographical ancestry...
January 20, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29352469/amoxicillin-current-use-in-swine-medicine
#7
REVIEW
D G S Burch, D Sperling
Amoxicillin has become a major antimicrobial substance in pig medicine for the treatment and control of severe, systemic infections such as Streptococcus suis. The minimum inhibitory concentration 90% (MIC 90) is 0.06 μg amoxicillin/ml, and the proposed epidemiological cut-off value (ECOFF) is 0.5 μg/ml, giving only 0.7% of isolates above the ECOFF or of reduced susceptibility. Clinical breakpoints have not been set for amoxicillin against porcine pathogens yet, hence the use of ECOFFs. It has also been successfully used for bacterial respiratory infections caused by Actinobacillus pleuropneumoniae and Pasteurella multocida...
January 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29352467/systematic-misclassification-of-gestational-age-by-ultrasound-biometry-implications-for-clinical-practice-and-research-methodology-in-the-nordic-countries
#8
Alkistis Skalkidou, Merit Kullinger, Marios K Georgakis, Helle Kieler, Ulrik S Kesmodel
Historically, pregnancy dating has been based on self-reported information on first day of the last menstrual period. In the 1970s, ultrasound biometry was introduced as an alternative for pregnancy dating, and is now the leading method in Nordic countries. The use of ultrasound led to a reduction of postterm births and fewer inductions and is considered more precise than last menstrual period-based methods for pregnancy dating. Nevertheless, differences in early growth and specific situations, such as maternal obesity, can render its estimates less precise, leading to gestational age misclassification...
January 20, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29352449/continuous-exposure-to-microplastics-does-not-cause-physiological-effects-in-the-cultivated-mussel-perna-perna
#9
Marina F M Santana, Fabiana T Moreira, Camilo D S Pereira, Denis M S Abessa, Alexander Turra
The environmental impact of microplastics is a challenging theme, especially under realistic experimental conditions. We investigated physiological responses to 0.1-1.0 μm PVC particles intake by the mussel Perna perna after a relative long-term exposure (90 days) at a less extreme concentration compared with previous studies (0.125 g/L). Microplastic intake was inferred by the presence of PVC in the feces of mussels, and physiological damages were assessed through ingestion rate, assimilation efficiency, growth rate, cellular and molecular biomarkers (lysosomal integrity, lipid peroxidation, and DNA damage), and condition index...
January 19, 2018: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29352436/posterolateral-tibial-plateau-fractures-how-to-buttress-reversed-l-posteromedial-or-the-posterolateral-approach-a-comparative-cadaveric-study
#10
Wich Orapiriyakul, Theerachai Apivatthakakul, Chanakarn Phornphutkul
INTRODUCTION: The selection of a surgical approach for buttressing posterolateral tibial plateau fractures is controversial. OBJECTIVE: This study compared the surgical exposure area between the reversed L posteromedial approach (R-PM) and the posterolateral (PL) approach using the lateral plateau width as a metric. MATERIALS AND METHODS: Twenty lower extremities from fresh frozen cadavers were included. The R-PM approach was used first and the boundary of the posterior tibial cortex exposure was marked with metal pins...
January 19, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29352303/perfusion-decellularization-of-a-human-limb-a-novel-platform-for-composite-tissue-engineering-and-reconstructive-surgery
#11
Mattia Francesco Maria Gerli, Jacques Paul Guyette, Daniele Evangelista-Leite, Brian Burns Ghoshhajra, Harald Christian Ott
Muscle and fasciocutaneous flaps taken from autologous donor sites are currently the most utilized approach for trauma repair, accounting annually for 4.5 million procedures in the US alone. However, the donor tissue size is limited and the complications related to these surgical techniques lead to morbidities, often involving the donor sites. Alternatively, recent reports indicated that extracellular matrix (ECM) scaffolds boost the regenerative potential of the injured site, as shown in a small cohort of volumetric muscle loss patients...
2018: PloS One
https://www.readbyqxmd.com/read/29352173/maize-chlorotic-mottle-virus-exhibits-low-divergence-between-differentiated-regional-sub-populations
#12
Luke Braidwood, Diego F Quito-Avila, Darlene Cabanas, Alberto Bressan, Anne Wangai, David C Baulcombe
Maize chlorotic mottle virus has been rapidly spreading around the globe over the past decade. The interactions of maize chlorotic mottle virus with Potyviridae viruses causes an aggressive synergistic viral condition - maize lethal necrosis, which can cause total yield loss. Maize production in sub-Saharan Africa, where it is the most important cereal, is threatened by the arrival of maize lethal necrosis. We obtained maize chlorotic mottle virus genome sequences from across East Africa and for the first time from Ecuador and Hawaii, and constructed a phylogeny which highlights the similarity of Chinese to African isolates, and Ecuadorian to Hawaiian isolates...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352162/a-prolonged-run-in-period-of-standard-subcutaneous-microdialysis-ameliorates-quality-of-interstitial-glucose-signal-in-patients-after-major-cardiac-surgery
#13
Othmar Moser, Julia Münzker, Stefan Korsatko, Christoph Pachler, Karlheinz Smolle, Wolfgang Toller, Thomas Augustin, Johannes Plank, Thomas R Pieber, Julia K Mader, Martin Ellmerer
We evaluated a standard subcutaneous microdialysis technique for glucose monitoring in two critically ill patient populations and tested whether a prolonged run-in period improves the quality of the interstitial glucose signal. 20 surgical patients after major cardiac surgery (APACHE II score: 10.1 ± 3.2) and 10 medical patients with severe sepsis (APACHE II score: 31.1 ± 4.3) were included in this investigation. A microdialysis catheter was inserted in the subcutaneous adipose tissue of the abdominal region...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352152/selection-and-validation-of-reference-genes-for-qrt-pcr-analysis-of-gene-expression-in-microsporum-canis-growing-under-different-adhesion-inducing-conditions
#14
Anita Ciesielska, Paweł Stączek
Dermatophytes are the group of filamentous fungi infecting keratinized structures such as skin, hair, and nails. Knowledge about genes and molecular mechanisms responsible for pathogenicity, as well as other biological properties of Microsporum canis is still relatively poor. The qRT-PCR is a reliable technique for quantifying gene expression across various biological processes, and choosing a set of suitable reference genes to normalize the expression data is a crucial step of this technique. We investigated the suitability of nine candidate reference genes: β-act, β-tub, adp-rf, ef1-α, sdha, rpl2, mbp1, psm1, and rGTPa for gene expression analysis in the dermatophyte M...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29351983/partial-tandem-duplication-of-kmt2a-mll-may-predict-a-subset-of-myelodysplastic-syndrome-with-unique-characteristics-and-poor-outcome
#15
Sarah M Choi, Rajan Dewar, Patrick W Burke, Lina Shao
Partial tandem duplication (PTD) of the KMT2A (MLL) gene is a poor prognostic factor in acute myeloid leukemia, but its significance in the context of myelodysplastic syndrome (MDS) is unknown. Here, we used cytogenomic array to identify MLL-PTD in a group of MDS patients and compared their clinicopathologic characteristics with a cohort of high-risk MDS patients without MLL-PTD. We show that MLL-PTD defines a subset of MDS characterized by high blast count, normal karyotype, and extremely poor prognosis exceeding that of non-MLL-PTD high risk MDS, including those with complex karyotype...
January 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29351939/retroperitoneal-bile-leak-after-laparoscopic-cholecystectomy
#16
Dee Zhen Lim, Enoch Wong, Sayed Hassen, Yahya Al-Habbal
Bile duct injury (BDI) is a well-recognised complication of laparoscopic cholecystectomy (LC). Following a BDI, bile usually leaks into the peritoneal space and causes biliary peritonitis. This manifests as non-specific abdominal pain and fever occurring several days after the surgery. It can be managed by laparoscopic washout with or without bile duct repair. We present a rare case of retroperitoneal bile leak post-LC. The mechanism of injury here was likely partial avulsion from excessive traction of the cystic duct during intraoperative cholangiogram...
January 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29351896/internet-exposure-associated-with-canadian-parents-perception-of-risk-on-childhood-immunization-cross-sectional-study
#17
Jordan Lee Tustin, Natasha Sarah Crowcroft, Dionne Gesink, Ian Johnson, Jennifer Keelan
BACKGROUND: There is a large presence of provaccination and antivaccination content on the Internet. The Internet has been identified as an important source for parents to seek and share vaccine information. There are concerns that parental fears or hesitancy on childhood immunizations are increasing due to the popularity of social media and exposure to online antivaccination sentiment. No other studies have investigated the association between seeking vaccine information online and Canadian parents' perception of risk on childhood immunization...
January 19, 2018: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/29351884/crucial-role-of-chelatable-iron-in-silver-nanoparticles-induced-dna-damage-and-cytotoxicity
#18
Agnieszka Grzelak, Maria Wojewódzka, Sylwia Meczynska-Wielgosz, Mariusz Zuberek, Dominika Wojciechowska, Marcin Kruszewski
Damage to mitochondria and subsequent ROS leakage is a commonly accepted mechanism of nanoparticle toxicity. However, malfunction of mitochondria results in generation of superoxide anion radical (O2•-), which due to the relatively low chemical reactivity is rather unlikely to cause harmful effects triggered by nanoparticles. We show that treatment of HepG2 cells with silver nanoparticles (AgNPs) resulted in generation of H2O2 instead of O2•-, as measured by ROS specific mitochondrial probes. Moreover, addition of a selective iron chelator diminished AgNPs toxicity...
January 9, 2018: Redox Biology
https://www.readbyqxmd.com/read/29351879/the-importance-of-monochromatic-lights-in-the-production-of-phenolic-acids-and-flavonoids-in-shoot-cultures-of-aronia-melanocarpa-aronia-arbutifolia-and-aronia%C3%A2-%C3%A3-%C3%A2-prunifolia
#19
Agnieszka Szopa, Anna Starzec, Halina Ekiert
Shoot cultures of Aronia melanocarpa, A. arbutifolia and A. × prunifolia were maintained on Murashige and Skoog medium with 1 mg/l each of BA and NAA under monochromatic lights (far-red, red, blue lights, UV-A-irradiation), in darkness, and under white light (control). HPLC-DAD analyses of 19 phenolic acids and 11 flavonoids in methanolic extracts from the shoots revealed in all of them the presence of three depsides (chlorogenic, neochlorogenic and rosmarinic acids), protocatechuic acid, four flavonoid glycosides (cynaroside, quercitrin, hyperoside and rutoside), and additionally, in A...
January 10, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29351871/systemic-signaling-in-response-to-wounding-and-pathogens
#20
REVIEW
Richard Hilleary, Simon Gilroy
Plants possess systemic signaling networks that allow the perception of local stresses to be translated into plant-wide responses. Although information can be propagated via a variety of molecules such as hormones and RNAs moving within the bulk flow of the phloem or in the transpiration stream, the vasculature also appears to be a major pathway whereby extremely rapid signals move bi-directionally throughout the plant. In these cases, the movement mechanisms are not dependent on redistribution through bulk flow...
January 16, 2018: Current Opinion in Plant Biology
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