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https://www.readbyqxmd.com/read/29029116/upregulation-of-irs1-enhances-igf1-response-in-y537s-and-d538g-esr1-mutant-breast-cancer-cells
#1
Zheqi Li, Kevin M Levine, Amir Bahreini, Peilu Wang, David Chu, Ben Ho Park, Steffi Oesterreich, Adrian V Lee
Increased evidence suggests that somatic mutations in the ligand binding domain of estrogen receptor (ERα/ESR1) are critical mediators of endocrine-resistant breast cancer progression. Insulin-like growth factor-1 (IGF1) is an essential regulator of breast development and tumorigenesis, and also has a role in endocrine resistance. A recent study showed enhanced crosstalk between IGF1 and ERα in ESR1 mutant cells, but detailed mechanisms are incompletely understood. Using genome-edited MCF-7 and T47D cell lines harboring Y537S and D538G ESR1 mutations, we characterized altered IGF1 signaling...
September 27, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028222/role-of-rbp2-induced-er-and-igf1r-erbb-signaling-in-tamoxifen-resistance-in-breast-cancer
#2
Hee-Joo Choi, Hyeong-Seok Joo, Hee-Young Won, Kyueng-Whan Min, Hyung-Yong Kim, Taekwon Son, Young-Ha Oh, Jeong-Yeon Lee, Gu Kong
Background: Despite the benefit of endocrine therapy, acquired resistance during or after treatment still remains a major challenge in estrogen receptor (ER)-positive breast cancer. We investigated the potential role of histone demethylase retinoblastoma-binding protein 2 (RBP2) in endocrine therapy resistance of breast cancer. Methods: Survival of breast cancer patients according to RBP2 expression was analyzed in three different breast cancer cohorts including METABRIC (n = 1980) and KM plotter (n = 1764)...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29028113/the-role-of-plin-protein-in-healthy-lipid-storage-and-lipid-droplet-expansion
#3
G C Hayward, R K Fenech, A J Yang, B J Baranowski
In skeletal muscle, fatty acids are stored in vesicle-like organelles known as lipid droplets (LDs). The importance of how lipids are stored in skeletal muscle has emerged from studies demonstrating a strong association between muscle lipids and insulin sensitivity. This article is protected by copyright. All rights reserved.
October 13, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29027995/microbiota-fmt-transiently-improves-insulin-sensitivity
#4
Claire Greenhill
No abstract text is available yet for this article.
October 13, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29027136/oligonol-promotes-glucose-uptake-by-modulating-the-insulin-signaling-pathway-in-insulin-resistant-hepg2-cells-via-inhibiting-protein-tyrosine-phosphatase-1b
#5
Himanshu Kumar Bhakta, Pradeep Paudel, Hajime Fujii, Atsuya Sato, Chan Hum Park, Takako Yokozawa, Hyun Ah Jung, Jae Sue Choi
Insulin resistance and protein tyrosine phosphatase 1B (PTP1B) overexpression are strongly associated with type 2 diabetes mellitus (T2DM), which is characterized by defects in insulin signaling and glucose intolerance. In a previous study, we demonstrated oligonol inhibits PTP1B and α-glucosidase related to T2DM. In this study, we examined the molecular mechanisms underlying the anti-diabetic effects of oligonol in insulin-resistant HepG2 cells. Glucose uptake was assessed using a fluorescent glucose tracer, 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxyglucose, and the signaling pathway was investigated by western blotting...
October 12, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29026804/the-effect-of-cardamom-supplementation-on-serum-lipids-glycemic-indices-and-blood-pressure-in-overweight-and-obese-pre-diabetic-women-a-randomized-controlled-trial
#6
Yaghooblou Fatemeh, Fereydoun Siassi, Abbas Rahimi, Fariba Koohdani, Farideh Doostan, Mostafa Qorbani, Gity Sotoudeh
BACKGROUND: Spice consumption helps the treatment of diseases due to their antioxidant and anti-inflammatory contents. Cardamom is one of this spices; therefore, this study is designed to determine the effect of cardamom supplementation on serum lipids, glycemic indices, and blood pressure in pre-diabetic women. METHODS: Eighty overweight or obese pre-diabetic women were randomly allocated to two groups. The intervention group received 3 g of green cardamom and the placebo group received 3 g of rusk powder for 2 months...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/29026762/correlation-of-vitamin-d-with-metabolic-parameters-in-polycystic-ovarian-syndrome
#7
Arun Kumar, Satish Barki, Vinod Raghav, Ashutosh Chaturvedi, K V S Hari Kumar
BACKGROUND: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS. MATERIALS AND METHODS: We included 100 PCOS patients (age 18-40 years, duration >6 months) serially, in this cross-sectional study. We excluded patients with past use of insulin sensitizers and hormone therapy...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026411/healthy-eating-index-and-cardiovascular-risk-factors-among-iranian-elderly-individuals
#8
Nafiseh Rashidipour-Fard, Majid Karimi, Sahar Saraf-Bank, Mohammad Hassan Baghaei, Fahimeh Haghighatdoost, Leila Azadbakht
BACKGROUND: Concurrent with increase in life expectancy, the prevalence of chronic diseases such as cardiovascular diseases (CVD) has also increased. Therefore, the aim of this study was to evaluate the association between healthy eating index (HEI) score and CVD risk factors among Iranian elderly. METHODS: This cross-sectional study was performed on a sample of elderly persons from Isfahan, Iran, in 2013. Totally, 107 retired subjects were entered in statistical analysis...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29025979/the-melatonin-receptor-agonist-piromelatine-ameliorates-impaired-glucose-metabolism-in-chronically-stressed-rats-fed-a-high-fat-diet
#9
Jun Zhou, Deng Wang, Xiaohong Luo, Xu Jia, Maoxing Li, Laudon Moshe, Ruxue Zhang, Zhengping Jia
Modern lifestyle factors (high-caloric food rich in fat) and daily chronic stress are important risk factors for metabolic disturbances. Increased hypothalamic-pituitary-adrenal (HPA) axis activity and the subsequent excess production of glucocorticoids (GCs) in response to chronic stress (CS) leads to increases in metabolic complications, such as type 2 diabetes and insulin resistance (IR). Melatonin (MLT), which protects several regulatory components of the HPA axis from GC-induced deterioration, might improve glucose homeostasis...
October 12, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29025280/effects-of-prenatal-ppar-%C3%AE-agonist-rosiglitazone-exposure-on-rat-hippocampus-development-in-a-time-dependent-manner-a-stereological-and-histopathological-study
#10
D Sağır, B Eren, B D Yılmaz, Z Eren, O N Keleş, A B Gökçe
Rosiglitazone is in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes mellitus. It works as an insulin sensitizer by binding to the peroxisome proliferator-activated receptor gamma. We investigated the effects of prenatally administered rosiglitazone on pyramidal cell numbers and morphologies in the hippocampus at postnatal period using histochemical and stereological techniques, congenital morphological properties and the number of offspring in rats. Eighteen female rats were grouped into control (C), low-dose rosiglitazone (LDR) and high-dose rosiglitazone (HDR)...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29025204/insulin-resistance-and-bone-age-advancement-in-girls-with-central-precocious-puberty
#11
Jin Ho Hur, Sora Park, Mo Kyung Jung, Seok Jin Kang, Ahreum Kwon, Hyun Wook Chae, Ho-Seong Kim, Duk Hee Kim
PURPOSE: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study was to determine whether insulin resistance is associated with bone age (BA) advancement in girls with CPP. METHODS: We retrospectively analyzed the records of 804 girls referred for puberty evaluation. Anthropometric measurements, BA, sex hormone, sex hormone binding globulin (SHBG), and insulin levels, lipid profiles, and gonadotropin releasing hormone stimulation tests were assessed...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29025201/the-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-in-overweight-korean-children-and-adolescents
#12
Dong-Yoon Yoo, Yu Sun Kang, Eun Byul Kwon, Eun-Gyong Yoo
PURPOSE: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio has recently been reported as a biomarker of cardiometabolic risk in obese children and adolescents. The purpose of this study is to describe the TG/HDL-C ratio and related factors in overweight and normal weight Korean children and to evaluate whether the high TG/HDL-C ratio is associated with insulin resistance in overweight children and adolescents. METHODS: Data from 255 overweight (aged 8...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29025046/decreased-insulin-secretion-in-pregnant-rats-fed-a-low-protein-diet
#13
Haijun Gao, Eric Ho, Meena Balakrishnan, Vijay Yechoor, Chandra Yallampalli
Low protein (LP) diet during pregnancy leads to reduced plasma insulin levels in rodents, but the underlying mechanisms remain unclear. Glucose is the primary insulin secretagogue and enhanced glucose stimulated insulin secretion (GSIS) in beta cells contributes to compensation for insulin resistance and maintenance of glucose homeostasis during pregnancy. In this study we hypothesized that plasma insulin levels in pregnant rats fed LP diet is reduced due to disrupted GSIS of pancreatic islets. We first confirmed reduced plasma insulin levels, then investigated in vivo insulin secretion by glucose tolerance test and ex vivo GSIS of pancreatic islets in the presence of glucose at different doses, and KCl, glibenclamide and L-arginine...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024807/reactive-oxygen-species-enhance-mitochondrial-function-insulin-sensitivity-and-glucose-uptake-in-skeletal-muscle-of-senescence-accelerated-prone-mice-samp8
#14
Valentin Barquissau, Frédéric Capel, Dominique Dardevet, Christine Feillet-Coudray, Anne Gallinier, Marie-Agnès Chauvin, Jennifer Rieusset, Béatrice Morio
Whereas reactive oxygen species (ROS) can have opposite impacts on insulin signaling, they have mainly been associated with mitochondrial dysfunction in skeletal muscle. We analyzed the relationship between these three features in skeletal muscle of senescence accelerated mice (SAM) prone (P8), which are characterized by enhanced oxidative stress compared to SAM resistant (R1). Oxidative stress, ROS production, antioxidant system, mitochondrial content and functioning, as well as in vitro and in vivo insulin signaling were investigated in gastrocnemius and quadriceps muscles...
October 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29023424/dietary-anthocyanins-and-insulin-resistance-when-food-becomes-a-medicine
#15
REVIEW
Tarun Belwal, Seyed Fazel Nabavi, Seyed Mohammad Nabavi, Solomon Habtemariam
Insulin resistance is an abnormal physiological state that occurs when insulin from pancreatic β-cells is unable to trigger a signal transduction pathway in target organs such as the liver, muscles and adipose tissues. The loss of insulin sensitivity is generally associated with persistent hyperglycemia (diabetes), hyperinsulinemia, fatty acids and/or lipid dysregulation which are often prevalent under obesity conditions. Hence, insulin sensitizers are one class of drugs currently employed to treat diabetes and associated metabolic disorders...
October 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29023387/combination-of-%C3%AE-glucan-and-morus-alba-l-leaf-extract-promotes-metabolic-benefits-in-mice-fed-a-high-fat-diet
#16
Jie Xu, Xiaojie Wang, Ke Cao, Zhizhong Dong, Zhihui Feng, Jiankang Liu
β-glucan (BG) and mulberry have received increasing attention for their benefits as natural sources of metabolic health. In the current study, we investigated the synergetic beneficial effects of BG and mulberry leaf extract (MLE) in mice fed a high-fat diet (HFD). Male C57BL6 mice were fed a HFD for twelve weeks to induce significant obesity and insulin resistance. BG and MLE were administrated orally throughout the feeding period. The administration of BG resulted in a significant reduction in body weight gain, perirenal fat mass, fasting insulin, serum lipids, serum inflammation markers, and fatty liver, showing systemic health improvement...
October 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29023014/influence-of-grand-multiparity-on-the-levels-of-insulin-glucose-and-homa-ir-in-comparison-with-nulliparity-and-primiparity
#17
Kamal Eldin Ahmed Abdelsalam, Abdelsamee Alobeid M Elamin
OBJECTIVE: It is to compare the levels of fasting glucose and insulin as well as insulin resistance in grand multiparas with primiparity and nulliparity. METHODOLOGY: Fasting blood samples were collected from 100 non-pregnant ladies as control group, 100 primiparity pregnant women and 100 grand multiparity pregnant women. Glucose (FBS) and insulin (FSI) concentrations were measured by Hitachi 912 full automated Chemistry Analyzer (Roche Diagnostics, Germany) as manufacturer procedure...
2017: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/29022350/sensitive-and-accurate-quantitation-of-phosphopeptides-using-tmt-isobaric-labeling-technique
#18
Xiaoyue Jiang, Ryan Bomgarden, Joseph Brown, Devin L Drew, Aaron M Robitaille, Rosa Viner, Andreas R Huhmer
Phosphorylation is an essential post-translational modification for regulating protein function and cellular signal transduction. Mass spectrometry (MS) combined with isobaric tandem mass tags (TMT) have become a powerful platform for simultaneous, large scale phospho-proteome site identification and quantitation. In order to improve the accuracy of isobaric tag-based quantitation in complex proteomic samples, MS3-based acquisition methods such as Synchronous Precursor Selection (SPS) have been used. However, the method suffers from lower peptide identification rates when applied to enriched phosphopeptide samples compared to unmodified samples due to differences in phosphopeptide fragmentation patterns during tandem MS...
October 12, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29022212/effect-of-food-on-the-pharmacokinetics-of-saroglitazar-magnesium-a-novel-dual-ppar%C3%AE-%C3%AE-agonist-in-healthy-adult-subjects
#19
Maulik R Patel, Kevinkumar A Kansagra, Devang P Parikh, Deven V Parmar, Hardik B Patel, Mayur M Soni, Uday S Patil, Harilal V Patel, Jaimik A Patel, Swagat S Gujarathi, Krupi V Parmar, Nuggehally R Srinivas
BACKGROUND AND OBJECTIVE: Peroxisome proliferator-activated receptors (PPARs) have recently become a focus of interest for their important roles in glucose and lipid metabolism. In humans, PPARα activation causes a decrease in plasma triglyceride (TG) levels, enhancement of high-density lipoprotein cholesterol (HDL-C) and simultaneous enhancement of very-low-density lipoprotein (VLDL) lipolysis, whereas PPARγ agonists act as insulin sensitizers and improve insulin resistance, which is very useful in patients with type 2 diabetes mellitus (T2DM)...
October 11, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/29021781/cross-talk-between-adipose-tissue-and-placenta-in-obese-and-gestational-diabetes-mellitus-pregnancies-via-exosomes
#20
REVIEW
Nanthini Jayabalan, Soumyalekshmi Nair, Zarin Nuzhat, Gregory E Rice, Felipe A Zuñiga, Luis Sobrevia, Andrea Leiva, Carlos Sanhueza, Jaime Agustín Gutiérrez, Martha Lappas, Dilys Jane Freeman, Carlos Salomon
Obesity is an important public health issue worldwide, where it is commonly associated with the development of metabolic disorders, especially insulin resistance (IR). Maternal obesity is associated with an increased risk of pregnancy complications, especially gestational diabetes mellitus (GDM). Metabolism is a vital process for energy production and the maintenance of essential cellular functions. Excess energy storage is predominantly regulated by the adipose tissue. Primarily made up of adipocytes, adipose tissue acts as the body's major energy reservoir...
2017: Frontiers in Endocrinology
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