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Yan P Yu, Ying Ding, Zhanghui Chen, Silvia Liu, Amantha Michalopoulos, Rui Chen, Zulfiqar G Gulzar, Bing Yang, Kathleen M Cieply, Alyssa Luvison, Bao-Guo Ren, James D Brooks, David Jarrard, Joel B Nelson, George K Michalopoulos, George C Tseng, Jian-Hua Luo
The mechanisms underlying the potential for aggressive behavior of prostate cancer (PCa) remain elusive. In this study, whole genome and/or transcriptome sequencing was performed on 19 specimens of PCa, matched adjacent benign prostate tissues, matched blood specimens, and organ donor prostates. A set of novel fusion transcripts was discovered in PCa. Eight of these fusion transcripts were validated through multiple approaches. The occurrence of these fusion transcripts was then analyzed in 289 prostate samples from three institutes, with clinical follow-up ranging from 1 to 15 years...
October 2014: American Journal of Pathology
Manish Kohli, Shaun M Riska, Douglas W Mahoney, High S Chai, David W Hillman, David N Rider, Brian A Costello, Rui Qin, Jatinder Lamba, Deepak M Sahasrabudhe, James R Cerhan
OBJECTIVE: To evaluate whether germline variations in genes involved in sex steroid biosynthesis and metabolic pathways predict time to treatment failure for patients with advanced prostate cancer undergoing androgen deprivation therapy (ADT), because there are few known clinical predictors of response. PATIENTS AND METHODS: In a cohort of 304 patients with advanced prostate cancer undergoing ADT, we genotyped 746 single-nucleotide polymorphisms (SNPs) from 72 genes from germline DNA (680 tagSNPs from 58 genes and 66 candidate SNPs from 20 genes [6 genes common in both])...
March 2012: Mayo Clinic Proceedings
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