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METTL21C

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https://www.readbyqxmd.com/read/27628047/association-between-snps-and-haplotypes-in-the-mettl21c-gene-and-peak-bone-mineral-density-and-body-composition-in-chinese-male-nuclear-families
#1
Fei Zhao, Li-Hong Gao, Shan-Shan Li, Zhan-Ying Wei, Wen-Zhen Fu, Jin-Wei He, Yu-Juan Liu, Yun-Qiu Hu, Jing Dong, Zhen-Lin Zhang
The methyltransferase-like 21C gene (METTL21C), which is mainly expressed in muscle, can promote the differentiation of myoblasts to myotubes and reduce glucocorticoid-induced apoptosis of osteocytes. The purpose of this study was to explore the association between single nucleotide polymorphisms of METTL21C and peak bone mineral density (BMD), body mass index, total fat mass (TFM), and total lean mass (TLM) in Chinese young men. Fifteen tagging single nucleotide polymorphisms were genotyped, and haplotype blocks were derived in 400 Chinese male nuclear families...
September 14, 2016: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/27404287/genetic-and-epigenetic-methylation-defects-and-implication-of-the-ermn-gene-in-autism-spectrum-disorders
#2
A Homs, M Codina-Solà, B Rodríguez-Santiago, C M Villanueva, D Monk, I Cuscó, L A Pérez-Jurado
Autism spectrum disorders (ASD) are highly heritable and genetically complex conditions. Although highly penetrant mutations in multiple genes have been identified, they account for the etiology of <1/3 of cases. There is also strong evidence for environmental contribution to ASD, which can be mediated by still poorly explored epigenetic modifications. We searched for methylation changes on blood DNA of 53 male ASD patients and 757 healthy controls using a methylomic array (450K Illumina), correlated the variants with transcriptional alterations in blood RNAseq data, and performed a case-control association study of the relevant findings in a larger cohort (394 cases and 500 controls)...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/26115316/saccharomyces-cerevisiae-eukaryotic-elongation-factor-1a-eef1a-is-methylated-at-lys-390-by-a-mettl21-like-methyltransferase
#3
Magnus E Jakobsson, Erna Davydova, Jędrzej Małecki, Anders Moen, Pål Ø Falnes
The human methyltransferases (MTases) METTL21A and VCP-KMT (METTL21D) were recently shown to methylate single lysine residues in Hsp70 proteins and in VCP, respectively. The yet uncharacterized MTase encoded by the YNL024C gene in Saccharomyces cerevisiae shows high sequence similarity to METTL21A and VCP-KMT, as well as to their uncharacterized paralogues METTL21B and METTL21C. Despite being most similar to METTL21A, the Ynl024c protein does not methylate yeast Hsp70 proteins, which were found to be unmethylated on the relevant lysine residue...
2015: PloS One
https://www.readbyqxmd.com/read/24677265/mettl21c-is-a-potential-pleiotropic-gene-for-osteoporosis-and-sarcopenia-acting-through-the-modulation-of-the-nf-%C3%AE%C2%BAb-signaling-pathway
#4
Jian Huang, Yi-Hsiang Hsu, Chenglin Mo, Eduardo Abreu, Douglas P Kiel, Lynda F Bonewald, Marco Brotto, David Karasik
Sarcopenia and osteoporosis are important public health problems that occur concurrently. A bivariate genome-wide association study (GWAS) identified METTL21c as a suggestive pleiotropic gene for both bone and muscle. The METTL21 family of proteins methylates chaperones involved in the etiology of both myopathy and inclusion body myositis with Paget's disease. To validate these GWAS results, Mettl21c mRNA expression was reduced with siRNA in a mouse myogenic C2C12 cell line and the mouse osteocyte-like cell line MLO-Y4...
July 2014: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
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