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glycogenic acanthosis

Yun Hee Kang, Hye Kyung Lee, Geon Park
Cowden syndrome (CS) is a rare autosomal dominant disorder characterized by multiple hamartomas in various tissues and cancers (breast, thyroid, and endometrium). We report CS of the esophagus and gastrointestinal tract that was incidentally detected by positron emission tomography/computed tomography (PET/CT) at postoperative surveillance in an endometrial cancer patient. PET/CT showed mildly increased FDG uptake along the entire esophagus and stomach. Upper GI endoscopy and histologic examination revealed glycogenic acanthosis of the esophagus and several hundred gastric polyps...
September 2016: Nuclear Medicine and Molecular Imaging
Ming-Wun Wong, Ming-Joug Bair, Shou-Chuan Shih, Cheng-Hsin Chu, Horng-Yuan Wang, Tsang-En Wang, Chen-Wang Chang, Ming-Jen Chen
AIM: To better understand some of the superficial tiny lesions that are recognized as squamous papilloma of the esophagus (SPE) and receive a different pathological diagnosis. METHODS: All consecutive patients with esophageal polypoid lesions detected by routine endoscopy at our Endoscopy Centre between October 2009 and June 2014 were retrospectively analysed. We enrolled patients with SPE or other superficial lesions to investigate four key endoscopic appearances (whitish color, exophytic growth, wart-like shape, and surface vessels) and used narrow band imaging (NBI) to distinguish their differences...
February 21, 2016: World Journal of Gastroenterology: WJG
Shu-Jung Tsai, Ching-Chung Lin, Chen-Wang Chang, Chien-Yuan Hung, Tze-Yu Shieh, Horng-Yuan Wang, Shou-Chuan Shih, Ming-Jen Chen
Benign esophageal lesions have a wide spectrum of clinical and pathologic features. Understanding the endoscopic and pathologic features of esophageal lesions is essential for their detection, differential diagnosis, and management. The purpose of this review is to provide updated features that may help physicians to appropriately manage these esophageal lesions. The endoscopic features of 2997 patients are reviewed. In epithelial lesions, the frequency of occurrence was in the following order: glycogenic acanthosis, heterotopic gastric mucosa, squamous papilloma, hyperplastic polyp, ectopic sebaceous gland and xanthoma...
January 28, 2015: World Journal of Gastroenterology: WJG
Y Kumagai, K Kawada, M Higashi, T Ishiguro, J Sobajima, M Fukuchi, K Ishibashi, H Baba, E Mochiki, J Aida, T Kawano, H Ishida, K Takubo
Endocytoscopy (ECS) is a novel endoscopic technique that allows detailed diagnostic examination of the gastrointestinal tract at the cellular level. We previously reported that use of ECS at ×380 magnification (GIF-Y0002) allowed a pathologist to diagnose esophageal squamous cell carcinoma (ESCC) with high sensitivity (94.9%) but considerably low specificity (46.7%) because this low magnification did not reveal information about nuclear abnormality. In the present study, we used the same magnifying endoscope to observe various esophageal lesions, but employed digital 1...
April 2015: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Robert Pilarski, Randall Burt, Wendy Kohlman, Lana Pho, Kristen M Shannon, Elizabeth Swisher
BACKGROUND: PTEN hamartoma tumor syndrome (PHTS) refers to a spectrum of disorders caused by mutations in the phosphatase and tensin homolog (PTEN) gene. Diagnostic criteria for Cowden syndrome, the principal PTEN-related disorder, were first established in 1996 before the identification of the PTEN gene and the ability to molecularly confirm a clinical diagnosis. These consortium criteria were based on clinical experience and case reports in the existing literature, with their inherent selection biases...
November 6, 2013: Journal of the National Cancer Institute
Almeida Elia C S, Etchebehere Renata M, Miranzi Benito A S, Santos Vitorino M, Reis Maria G
HIV infections frequently affect the oral cavity, and local changes may be utilized as indicators of immunosuppression in HIV-positive patients. Morphometric and morphological features of the lining, masticatory, and specialized epithelium of the oral mucosa were studied in 12 HIV-positive and 12 HIV-negative patients autopsied from 2007 to 2010. Mucosal samples from the cheek, gingival, and tongue of 24 individuals were fixed in Carnoy solution and stained with hematoxylin-eosin. Various morphometric characteristics (epithelial thickness, number of cell layers, mean cell diameter) and morphological parameters (basal layer hyperplasia, exocytosis of inflammatory cells, glycogenic acanthosis, cell ballooning degeneration) were then measured...
July 2013: Pathology, Research and Practice
Tadashi Terada
The author reviewed 910 cases of consecutive esophageal biopsies in the last 15 year in the pathology laboratory of our hospital. There were 693 normal mucosa and benign lesions (76.2%) and 217 malignant lesions (23.8%). No significant changes were recognized in the esophagus in 50 biopsies (5.5%). In benign lesions, the number and frequency (percentages) were as follows: 263 chronic esophagitis (28.9%), 98 heterotopic gastric mucosa (10.8%), 3 heterotopic colonic mucosa (0.3%), 71 glycogenic acanthosis (7...
2013: International Journal of Clinical and Experimental Pathology
Yaşar Nazligül, Mehmet Aslan, Ramazan Esen, Abdullah Özgür Yeniova, Ayşe Kefeli, Metin Küçükazman, Ahmet Cumhur Dülger, Yilmaz Celik
BACKGROUND/AIMS: Glycogenic acanthosis is described as benign thickening of the esophageal squamous epithelium of unknown etiology. Although its etiology is unknown, it has been reported that glycogenic acanthosis may be related to gastroesophageal reflux and hiatal hernia. The aim of the present study was to review the patients who were diagnosed with glycogenic acanthosis on upper gastrointestinal endoscopy and to determine whether there is any association between glycogenic acanthosis and gastroesophageal reflux and hiatal hernia...
June 2012: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
L Montebugnoli, L Felicetti, F Cervellati, M P Foschini
This report describes a rare case of glycogenic acanthosis (GA) located on the tongue of a 72-year-old man. The patient presented with a white plaque that had been on the right side of the tongue for 5 years. Histologically, the lesion was characterised by thickened squamous epithelium with abundant intracellular glycogen deposits. No epithelial dysplasia was noted. This is the first report of GA involving the tongue. This benign condition should be added to the large number of lesions responsible for leukoplakia in this anatomical location...
2010: BMJ Case Reports
Abderrahmen Masmoudi, Zied Mohamed Chermi, Slaheddine Marrekchi, Ben Salah Raida, Sonia Boudaya, Madiha Mseddi, Meziou Taha Jalel, Hamida Turki
BACKGROUND: Cowden syndrome is a rare genodermatosis charactarized by presence of multiple hamartomas. The aim of the study was to specify the clinical, therapeutic and prognostic aspects of Cowden syndrome. CASES REPORT: Our study included 4 patients with Cowden syndrome, 2 males and 2 females between 14 and 46 years old. Clinical examination of the skin revealed facials papules (4 cases), acral keratosis (1 case), translucent keratotic papules (2 cases). Oral examination revealed papules (4 cases), papillomatosis (4 cases), gingival hypertrophy (4 cases) and scrotal tongue (2 cases)...
March 26, 2011: Journal of Dermatological Case Reports
R Coriat, M Mozer, F Caux, E Caux, A Chryssostalis, B Terris, S Grandjouan, R Benamouzig, A Martin, S Chaussade
Cowden syndrome is characterized by diffuse hamartomas involving the whole digestive tract. The gastrointestinal expression of the disease is inconstant, but hamartomatous polyposes are frequent. In a multicenter study we studied the endoscopic appearance of Cowden syndrome--as defined by fulfillment of international consortium criteria--in 10 patients. In 6 of the 10 patients the connection with Cowden syndrome was made retrospectively on the basis of the gastrointestinal endoscopic findings. All patients had upper and lower gastrointestinal tract involvement...
August 2011: Endoscopy
A Nishizawa, T Satoh, R Watanabe, K Takayama, H Nakano, D Sawamura, H Yokozeki
No abstract text is available yet for this article.
May 2009: British Journal of Dermatology
Khalid Al-Thihli, Laura Palma, Victoria Marcus, Matthew Cesari, Yael B Kushner, Alan Barkun, William D Foulkes
BACKGROUND: A 73-year-old white man was referred to a cancer genetics clinic for evaluation of a approximately 20-year history of mixed upper and lower gastrointestinal polyposis, including hyperplastic, inflammatory and adenomatous polyps, colonic ganglioneuromas, and associated diffuse, esophageal glycogenic acanthosis. Two synchronous gastric carcinomas had been identified before referral and the patient had undergone a total gastrectomy, omentectomy and cholecystectomy. Multiple hyperplastic polyps and small, sessile polyps were also observed in the gastrectomy specimen...
March 2009: Nature Clinical Practice. Gastroenterology & Hepatology
Mee-Yon Cho, Hyun Soo Kim, Charis Eng, Dae Sung Kim, Seong Joon Kang, Minseob Eom, Sang Yeop Yi, Mary P Bronner
We present the first report of ovarian dysgerminoma in Cowden syndrome, presenting in a 7-year-old girl. In her second decade, a hamartomatous soft tissue extremity mass and diffuse gastrointestinal hamartomatous polyposis with pathologic features suggestive of either juvenile, Peutz-Jeghers, or Cowden polyps were identified, along with diffuse esophageal glycogenic acanthosis and skin manifestations. During regular thyroid cancer surveillance under the provisional diagnosis of Cowden syndrome, papillary thyroid carcinoma and benign follicular nodules were diagnosed at age 23...
August 2008: American Journal of Surgical Pathology
J K Lee, J Kum, P Ghosh
No abstract text is available yet for this article.
September 2007: Journal of Gastroenterology and Hepatology
Peter Vasovcak, Anna Krepelova, Alena Puchmajerova, Julius Spicak, Ludek Voska, Andrea Musilova, Jan Mestak, Jan Martinek
Cowden syndrome is an inherited disease characterized by mucocutaneous lesions, gastrointestinal hamartomatous polyposis and an increased risk of breast, thyroid and endometrial carcinomas. Despite well described phenotypic expression of this disease, it is not easy to determine correct clinical diagnosis. In this case report we present a clinical history of a patient with Cowden syndrome. When he was 22 years old, he was found to have polyposis of gastrointestinal tract. The diagnosis of Peutz-Jeghers syndrome was established...
June 2007: European Journal of Gastroenterology & Hepatology
Hajime Isomoto, Hisashi Furusu, Ken Ohnita, Yusuke Takehara, Chun-Yang Wen, Shigeru Kohno
A 21-year-old woman with complaints of hematochezia was diagnosed as having Cowden's disease (CD), an autosomal dominant condition characterized by multiple hamartomas, since facial papules and gingival papillomas were identified. On endoscopy, multiple hyperplastic polyps were seen in the rectum and left-side colon. There were also esophageal glycogenic acanthosis and hyperplastic polyposis in the antrum accompanied by Helicobacter pylori-related gastritis. Although gastric hyperplastic polyposis had by no means regressed with unsuccessful first-line eradication therapy for H pylori, following cure of the infection with salvage therapy consisting of rabeprazole, amoxicillin and metronidazole, the polyposis lesions almost disappeared...
March 14, 2005: World Journal of Gastroenterology: WJG
O D Suoglu, H H Emiroglu, S Sokucu, S Cantez, U Cevikbas, G Saner
UNLABELLED: A 6-y-old boy and an 8-y-old girl were admitted to our clinic with anaemia and failure to thrive. Laboratory tests revealed iron deficiency anaemia and positive antigliadin antibodies in both of the patients. Slightly raised grey-white plaques were observed on oesophageal mucosa during endoscopical investigation of the patients. While intestinal mucosal samples confirmed diagnosis of celiac disease histologically, histopathological assessment of oesophageal lesions demonstrated glycogenic acanthosis...
April 2004: Acta Paediatrica
Peter C Belafsky
No abstract text is available yet for this article.
April 2004: Ear, Nose, & Throat Journal
Atsushi Katagiri, Kazuhiro Kaneko, Kazuo Konishi, Hiroaki Ito, Miki Kushima, Keiji Mitamura
BACKGROUND/AIMS: Squamous cell carcinoma of the esophagus often arises in the setting of chronic esophagitis. We investigated whether chronic esophagitis was associated with carcinogenesis in the esophageal squamous epithelium. METHODOLOGY: Videoendoscopy with Lugol staining was performed in 70 patients with invasive carcinoma of the esophagus. We especially focused the study on background epithelium of the esophagus, then background epithelium was classified into two groups according to differences in Lugol staining patterns...
May 2004: Hepato-gastroenterology
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