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https://www.readbyqxmd.com/read/29223072/alteration-of-autophagy-related-proteins-in-peripheral-blood-mononuclear-cells-of-patients-with-parkinson-s-disease
#1
Yasuo Miki, Shuji Shimoyama, Tomoya Kon, Tatsuya Ueno, Ryo Hayakari, Kunikazu Tanji, Tomoh Matsumiya, Eiki Tsushima, Fumiaki Mori, Koichi Wakabayashi, Masahiko Tomiyama
Previous postmortem studies demonstrated dysregulation of autophagy in patients with Parkinson's disease (PD). To clarify whether this alteration reflects a fundamental aspect of PD or represents the final stage of autophagy dysregulation resulting from a long neurodegenerative process, we focused on basal autophagy in peripheral blood mononuclear cells (PBMCs) of PD patients (n = 35) and controls (n = 23). The whole-transcriptome assay revealed downregulation of mRNAs for 6 core regulators of autophagy (UNC-51-like kinase [ULK] 3, autophagy-related [Atg] 2A, Atg4B, Atg5, Atg16L1, and histone deacetylase 6)...
November 21, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29222939/which-outcomes-are-reported-in-cellulitis-trials-results-of-a-review-of-outcomes-included-in-cellulitis-trials-and-a-patient-priority-setting-survey
#2
REVIEW
E Smith, M Patel, K Thomas
BACKGROUND: There is an emerging need to develop consistent outcomes in clinical trials to allow effective comparison of treatment effects. No systematic review has previously looked at the reporting of outcome measures used in randomised controlled trials (RCTs) on treatment and prevention of cellulitis (erysipelas). OBJECTIVES: The primary aim of this review was to describe the breadth of outcomes reported from RCTs on cellulitis treatment and prevention. The secondary aim was to identify outcome themes from patient and health care professionals' feedback from a cellulitis priority setting partnership (PSP)...
December 9, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29220402/bodily-motion-fluctuation-improves-reaching-success-rate-in-a-neurophysical-agent-via-geometric-stochastic-resonance
#3
Shogo Yonekura, Yasuo Kuniyoshi
Organisms generate a variety of noise types, including neural noise, sensory noise, and noise resulting from fluctuations associated with movement. Sensory and neural noises are known to induce stochastic resonance (SR), which improves information transfer to the subjects control systems, including the brain. As a consequence, sensory and neural noise provide behavioral benefits, such as stabilization of posture and enhancement of feeding efficiency. In contrast, the benefits of fluctuations in the movements of a biological system remain largely unclear...
2017: PloS One
https://www.readbyqxmd.com/read/29220348/the-pea-branching-rms2-gene-encodes-the-psafb4-5-auxin-receptor-and-is-involved-in-an-auxin-strigolactone-regulation-loop
#4
Yasmine Ligerot, Alexandre de Saint Germain, Tanya Waldie, Christelle Troadec, Sylvie Citerne, Nikita Kadakia, Jean-Paul Pillot, Michael Prigge, Grégoire Aubert, Abdelhafid Bendahmane, Ottoline Leyser, Mark Estelle, Frédéric Debellé, Catherine Rameau
Strigolactones (SLs) are well known for their role in repressing shoot branching. In pea, increased transcript levels of SL biosynthesis genes are observed in stems of highly branched SL deficient (ramosus1 (rms1) and rms5) and SL response (rms3 and rms4) mutants indicative of negative feedback control. In contrast, the highly branched rms2 mutant has reduced transcript levels of SL biosynthesis genes. Grafting studies and hormone quantification led to a model where RMS2 mediates a shoot-to-root feedback signal that regulates both SL biosynthesis gene transcript levels and xylem sap levels of cytokinin exported from roots...
December 8, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29218250/evaluation-of-the-role-of-downregulation-of-snf5-ini1-core-subunit-of-swi-snf-complex-in-clear-cell-renal-cell-carcinoma-development
#5
Elzbieta Sarnowska, Michal Szymanski, Nataliia Rusetska, Marcin Ligaj, Iga Jancewicz, Pawel Cwiek, Marta Skrodzka, Marcin Leszczynski, Joanna Szarkowska, Alicja Chrzan, Malgorzata Stachowiak, Jaroslaw Steciuk, Anna Maassen, Lech Galek, Tomasz Demkow, Janusz A Siedlecki, Tomasz J Sarnowski
Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in von Hippel-Lindau (VHL) gene. Additionally, in about 40% of ccRCC cases the mutation in PBRM1 (POLYBROMO1) gene coding for a non-core subunit of SWI/SNF chromatin remodeling complex was found suggesting potential impairment of this complex function in ccRCC. In this study we assessed the extent to which the core SWI/SNF complex subunit - INI1 (hSNF5/SMARCB1) is affected in ccRCC and whether it has any consequences on the development of this type of cancer...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29218127/the-effect-of-group-discussion-based-education-on-self-management-of-adults-with-type-2-diabetes-mellitus-compared-with-usual-care-a-randomized-control-trial
#6
Hosein Habibzadeh, Akbar Sofiani, Leyla Alilu, Mark Gillespie
Objectives: We sought to determine the effect of group discussion-based education on the self-management capability of patients with type 2 diabetes in Iran. Methods: This randomized control trial was conducted on 90 patients with type 2 diabetes. Participants were allocated randomly into one of two groups; intervention and control. The intervention group received the group discussion-based education while the control group received routine care only. The Lin's self-management questionnaire was completed at baseline and three months post-intervention...
November 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/29218022/association-between-unintentional-interpersonal-postural-coordination-produced-by-interpersonal-light-touch-and-the-intensity-of-social-relationship
#7
Tomoya Ishigaki, Ryota Imai, Shu Morioka
Interpersonal postural coordination (IPC) produced by interpersonal light touch (ILT), whereby time-series variations in the postural sway between two people unintentionally resemble each other, may be a possible social interaction. From a sociopsychological standpoint, close mutual behavioral coordination is recognized as "social glue," which represents the closeness of relationships and contributes to the building of a good rapport. Therefore, we hypothesized that if IPC functions as social glue, then IPC produced by ILT also represents a social relationship...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29216112/real-time-physical-random-bit-generation-at-gbps-based-on-random-fiber-lasers
#8
Yanping Xu, Ping Lu, Stephen Mihailov, Xiaoyi Bao
We demonstrate for the first time, to the best of our knowledge, a high-speed physical random bit generator at gigabits/second without the time-delay signature based on chaotic power fluctuations of a random fiber laser. The random fiber laser is configured using a ring structure with semiconductor optical amplifiers as the optical gain and a fiber random grating as the random feedback medium. The long-length ring cavity provides a large number of densely spaced cavity modes that co-exist within the gain bandwidth tailored by the optical filter...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29215961/analysis-of-air-quality-in-dire-dawa-ethiopia
#9
Oluwasinaayomi Faith Kasim, Muluneh Woldetisadik Abshare, Samuel Babatunde Agbola
Ambient air quality was monitored and analysed to develop air quality index and its implications for liveability and climate change in Dire Dawa, Ethiopia. Using survey research design, 16 geo-referenced locations, representing different land uses, were randomly selected and assessed for sulphur dioxide (SO2) nitrogen dioxide (NO2), carbon dioxide (CO2), carbon monoxide (CO),Volatile Organic Compound (VOC) and meteorological parameters (temperature and relative humidity). The study found mean concentrations across all land uses for SO2 of 0...
December 7, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/29214975/home-based-health-promotion-for-older-people-with-mild-frailty-the-homehealth-intervention-development-and-feasibility-rct
#10
Kate Walters, Rachael Frost, Kalpa Kharicha, Christina Avgerinou, Benjamin Gardner, Federico Ricciardi, Rachael Hunter, Ann Liljas, Jill Manthorpe, Vari Drennan, John Wood, Claire Goodman, Ana Jovicic, Steve Iliffe
BACKGROUND: Mild frailty or pre-frailty is common and yet is potentially reversible. Preventing progression to worsening frailty may benefit individuals and lower health/social care costs. However, we know little about effective approaches to preventing frailty progression. OBJECTIVES: (1) To develop an evidence- and theory-based home-based health promotion intervention for older people with mild frailty. (2) To assess feasibility, costs and acceptability of (i) the intervention and (ii) a full-scale clinical effectiveness and cost-effectiveness randomised controlled trial (RCT)...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29214241/text-messaging-may-engage-and-benefit-adults-with-type-2-diabetes-regardless-of-health-literacy-status
#11
Erin M Bergner, Lyndsay A Nelson, Russell L Rothman, Lindsay Mayberry
Background: Technology-delivered interventions have the potential to improve diabetes self-care and glycemic control among adults with type 2 diabetes (T2D). However, patients who do not engage with interventions may not reap benefits, and there is little evidence on how engagement with mobile health interventions varies by health literacy status. Objective: This study explored how patients with limited health literacy engaged with and experienced Rapid Education/Encouragement and Communications for Health (REACH), a text messaging intervention designed to support the self-care adherence of disadvantaged patients with T2D...
October 2017: Health Literacy Research and Practice
https://www.readbyqxmd.com/read/29214128/a-clinic-based-assessment-for-evaluating-job-related-social-skills-in-adolescents-and-adults-with-autism
#12
Dorothea C Lerman, Bridgette White, Carolyn Grob, Courtney Laudont
Many individuals with autism spectrum disorder (ASD) have difficulties obtaining and maintaining employment, yet little research has evaluated methods for assessing and improving critical vocational skills. In this study, we evaluated an assessment of job-related social skills for individuals with ASD by arranging conditions that simulated on-the-job experiences in a clinic setting. The experimenter contrived situations to assess a variety of social skills, including asking for help, asking for more materials, and responding to corrective feedback...
December 2017: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29213235/changes-in-predictive-task-switching-with-age-and-with-cognitive-load
#13
Shelly Levy-Tzedek
Predictive control of movement is more efficient than feedback-based control, and is an important skill in everyday life. We tested whether the ability to predictively control movements of the upper arm is affected by age and by cognitive load. A total of 63 participants were tested in two experiments. In both experiments participants were seated, and controlled a cursor on a computer screen by flexing and extending their dominant arm. In Experiment 1, 20 young adults and 20 older adults were asked to continuously change the frequency of their horizontal arm movements, with the goal of inducing an abrupt switch between discrete movements (at low frequencies) and rhythmic movements (at high frequencies)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29213229/reflex-modification-audiometry-reveals-dual-roles-for-olivocochlear-neurotransmission
#14
Paul D Allen, Anne E Luebke
Approximately 15% of American adults report some degree of difficulty hearing in a noisy environment or have auditory filtering difficulties. There are objective clinical tests of auditory filtering, yet few tests exist for mouse models that do not rely on extensive training. We have used reflex modification audiometry (RMA) and developed exclusion criteria for the mouse model. This RMA based test makes use of the acoustic startle response (ASR) and the ability of prepulses to inhibit the ASR [i.e., prepulse inhibition (PPI)] to assess the mouse's ability to detect prepulse signals presented in quiet or embedded in masking noise...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29212757/the-tactile-perception-of-transient-changes-in-friction
#15
David Gueorguiev, Eric Vezzoli, André Mouraux, Betty Lemaire-Semail, Jean-Louis Thonnard
When we touch an object or explore a texture, frictional strains are induced by the tactile interactions with the surface of the object. Little is known about how these interactions are perceived, although it becomes crucial for the nascent industry of interactive displays with haptic feedback (e.g. smartphones and tablets) where tactile feedback based on friction modulation is particularly relevant. To investigate the human perception of frictional strains, we mounted a high-fidelity friction modulating ultrasonic device on a robotic platform performing controlled rubbing of the fingertip and asked participants to detect induced decreases of friction during a forced-choice task...
December 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29212475/implementation-of-shared-decision-making-in-oncology-development-and-pilot-study-of-a-nurse-led-decision-coaching-programme-for-women-with-ductal-carcinoma-in-situ
#16
Birte Berger-Höger, Katrin Liethmann, Ingrid Mühlhauser, Anke Steckelberg
BACKGROUND: To implement informed shared decision-making (ISDM) in breast care centres, we developed and piloted an inter-professional complex intervention. METHODS: We developed an intervention consisting of three components: an evidence-based patient decision aid (DA) for women with ductal carcinoma in situ, a decision-coaching led by specialised nurses (breast care nurses and oncology nurses) and structured physician encounters. In order to enable professionals to gain ISDM competencies, we developed and tested a curriculum-based training programme for specialised nurses and a workshop for physicians...
December 6, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29212345/a-pilot-investigation-of-an-ios-based-app-for-toilet-training-children-with-autism-spectrum-disorder
#17
Daniel W Mruzek, Stephen McAleavey, Whitney A Loring, Eric Butter, Tristram Smith, Erin McDonnell, Lynne Levato, Courtney Aponte, Rebekah P Travis, Rachel E Aiello, Cora M Taylor, Jonathan W Wilkins, Patricia Corbett-Dick, Dianne M Finkelstein, Alyssa M York, Katherine Zanibbi
We developed an iOS-based app with a transmitter/disposable sensor and corresponding manualized intervention for children with autism spectrum disorder. The app signaled the onset of urination, time-stamped accidents for analysis, reminded parents to reinforce intervals of continence, provided a visual outlet for parents to communicate reinforcement, and afforded opportunity for timely feedback from clinicians. We compared this intervention with an intervention that uses standard behavioral treatment in a pilot randomized controlled trial of 33 children with autism spectrum disorder aged 3-6 years with urinary incontinence...
December 1, 2017: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/29211627/proprioceptive-flexible-fluidic-actuators-using-conductive-working-fluids
#18
Tim Helps, Jonathan Rossiter
Soft robotic systems generally require both soft actuators and soft sensors to perform complex functions. Separate actuators and sensors are often combined into one composite device when proprioception (self-sensing) is required. In this article, we introduce the concept of using a conductive liquid to perform both the sensing and actuation functions of a proprioceptive soft actuator. The working fluid drives actuator deformation while simultaneously acting as a strain-sensing component for detecting actuator deformation...
December 6, 2017: Soft Robotics
https://www.readbyqxmd.com/read/29210791/design-and-evaluation-of-a-closed-loop-anesthesia-system-with-robust-control-and-safety-system
#19
Nicholas West, Klaske van Heusden, Matthias Görges, Sonia Brodie, Aryannah Rollinson, Christian L Petersen, Guy A Dumont, J Mark Ansermino, Richard N Merchant
BACKGROUND: Closed-loop control of anesthesia involves continual adjustment of drug infusion rates according to measured clinical effect. The NeuroSENSE monitor provides an electroencephalographic measure of depth of hypnosis (wavelet-based anesthetic value for central nervous system monitoring [WAVCNS]). It has previously been used as feedback for closed-loop control of propofol, in a system designed using robust control engineering principles, which implements features specifically designed to ensure patient safety...
November 22, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29209188/age-related-decline-of-wrist-position-sense-and-its-relationship-to-specific-physical-training
#20
Ann Van de Winckel, Yu-Ting Tseng, Daniel Chantigian, Kaitlyn Lorant, Zinat Zarandi, Jeffrey Buchanan, Thomas A Zeffiro, Mia Larson, Becky Olson-Kellogg, Jürgen Konczak, Manda L Keller-Ross
Perception of limb and body positions is known as proprioception. Sensory feedback, especially from proprioceptive receptors, is essential for motor control. Aging is associated with a decline in position sense at proximal joints, but there is inconclusive evidence of distal joints being equally affected by aging. In addition, there is initial evidence that physical activity attenuates age-related decline in proprioception. Our objectives were, first, to establish wrist proprioceptive acuity in a large group of seniors and compare their perception to young adults, and second, to determine if specific types of training or regular physical activity are associated with preserved wrist proprioception...
2017: Frontiers in Human Neuroscience
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