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https://www.readbyqxmd.com/read/28345030/wearable-disposable-sweat-based-glucose-monitoring-device-with-multistage-transdermal-drug-delivery-module
#1
Hyunjae Lee, Changyeong Song, Yong Seok Hong, Min Sung Kim, Hye Rim Cho, Taegyu Kang, Kwangsoo Shin, Seung Hong Choi, Taeghwan Hyeon, Dae-Hyeong Kim
Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging...
March 2017: Science Advances
https://www.readbyqxmd.com/read/28344052/keeping-fat-on-time-circadian-control-of-adipose-tissue
#2
REVIEW
Stine Ninel Hansen, Julia Peics, Zachary Gerhart-Hines
Circadian clocks harmonize processes ranging from intracellular biochemistry to whole-body physiology in accordance with the Earth's 24 hour rotation. These intrinsic oscillators are based on an interlocked transcriptional-translational feedback loop comprised from a set of core clock factors. In addition to maintaining rhythmicity in nearly every cell of the body, these clock factors also mediate tissue specific metabolic functions. In this review, we will explore how the molecular clock shapes the unique features of different adipose depots...
March 23, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28343334/design-and-test-of-a-microsoft-kinect-based-system-for-delivering-adaptive-visual-feedback-to-stroke-patients-during-training-of-upper-limb-movement
#3
Daniel Simonsen, Mirjana B Popovic, Erika G Spaich, Ole Kæseler Andersen
The present paper describes the design and test of a low-cost Microsoft Kinect-based system for delivering adaptive visual feedback to stroke patients during the execution of an upper limb exercise. Eleven sub-acute stroke patients with varying degrees of upper limb function were recruited. Each subject participated in a control session (repeated twice) and a feedback session (repeated twice). In each session, the subjects were presented with a rectangular pattern displayed on a vertical mounted monitor embedded in the table in front of the patient...
March 25, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28342901/the-sympathetic-neuro-adipose-connection-and-the-control-of-body-weight
#4
REVIEW
Inês Mahú, Ana I Domingos
In recent decades, obesity has become a global public health crisis irrespective of age or gender [21]. But according to historic records, concerns over appropriate maintenance of body size have been long established. For more than to 2 millennia, the main therapeutic approach to curb excess weight has been to recommend dietary restrictions and regular exercise (Haslam, 2016). Nevertheless, more contemporary studies indicate that the employment of such approaches in the treatment of severely obese patients causes metabolic adaptions which impair their long-term success in weight management [8]...
March 22, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28342397/conflict-adaptation-in-positive-and-negative-mood-applying-a-success-failure-manipulation
#5
Stefanie Schuch, Jana Zweerings, Patricia Hirsch, Iring Koch
Conflict adaptation is a cognitive mechanism denoting increased cognitive control upon detection of conflict. This mechanism can be measured by the congruency sequence effect, indicating the reduction of congruency effects after incongruent trials (where response conflict occurs) relative to congruent trials (without response conflict). Several studies have reported increased conflict adaptation under negative, as compared to positive, mood. In these studies, sustained mood states were induced by film clips or music combined with imagination techniques; these kinds of mood manipulations are highly obvious, possibly distorting the actual mood states experienced by the participants...
March 22, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28342214/real-time-fmri-neurofeedback-in-adolescents-with-attention-deficit-hyperactivity-disorder
#6
Analucia A Alegria, Melanie Wulff, Helen Brinson, Gareth J Barker, Luke J Norman, Daniel Brandeis, Daniel Stahl, Anthony S David, Eric Taylor, Vincent Giampietro, Katya Rubia
Attention Deficit Hyperactivity Disorder (ADHD) is associated with poor self-control, underpinned by inferior fronto-striatal deficits. Real-time functional magnetic resonance neurofeedback (rtfMRI-NF) allows participants to gain self-control over dysregulated brain regions. Despite evidence for beneficial effects of electrophysiological-NF on ADHD symptoms, no study has applied the spatially superior rtfMRI-NF neurotherapy to ADHD. A randomized controlled trial tested the efficacy of rtfMRI-NF of right inferior prefrontal cortex (rIFG), a key region that is compromised in ADHD and upregulated with psychostimulants, on improvement of ADHD symptoms, cognition, and inhibitory fMRI activation...
March 25, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28341619/assessing-feasibility-and-acceptability-of-web-based-enhanced-relapse-prevention-for-bipolar-disorder-erponline-a-randomized-controlled-trial
#7
Fiona Lobban, Alyson L Dodd, Adam P Sawczuk, Ozgur Asar, Dave Dagnan, Peter J Diggle, Martin Griffiths, Mahsa Honary, Dawn Knowles, Rita Long, Richard Morriss, Rob Parker, Steven Jones
BACKGROUND: Interventions that teach people with bipolar disorder (BD) to recognize and respond to early warning signs (EWS) of relapse are recommended but implementation in clinical practice is poor. OBJECTIVES: The objective of this study was to test the feasibility and acceptability of a randomized controlled trial (RCT) to evaluate a Web-based enhanced relapse prevention intervention (ERPonline) and to report preliminary evidence of effectiveness. METHODS: A single-blind, parallel, primarily online RCT (n=96) over 48 weeks comparing ERPonline plus usual treatment with "waitlist (WL) control" plus usual treatment for people with BD recruited through National Health Services (NHSs), voluntary organizations, and media...
March 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28341617/internet-delivered-health-interventions-that-work-systematic-review-of-meta-analyses-and-evaluation-of-website-availability
#8
Mary Am Rogers, Kelsey Lemmen, Rachel Kramer, Jason Mann, Vineet Chopra
BACKGROUND: Due to easy access and low cost, Internet-delivered therapies offer an attractive alternative to improving health. Although numerous websites contain health-related information, finding evidence-based programs (as demonstrated through randomized controlled trials, RCTs) can be challenging. We sought to bridge the divide between the knowledge gained from RCTs and communication of the results by conducting a global systematic review and analyzing the availability of evidence-based Internet health programs...
March 24, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28341334/h-%C3%A2-output-feedback-fuzzy-proportional-integral-control-of-fully-delayed-input-output-systems
#9
Chian-Song Chiu, Tung-Sheng Chiang
This paper presents the output-feedback fuzzy proportional-integral (PI) controller design for uncertain nonlinear systems with both fully delayed input and output. Based on the Takagi-Sugeno (T-S) fuzzy model representation, the output-feedback PI control is realized via parallel distributed PI compensation and novel LMI gain design. Although the T-S fuzzy PI controller is simple, asymptotic output regulation is assured to overcome the effect of uncertainty, state delay, and full input/output delays. When considering disturbance and measurement noise, the control performance is achieved by robust gain design...
January 2017: ISA Transactions
https://www.readbyqxmd.com/read/28341333/h%C3%A2-control-for-a-class-of-singular-systems-with-state-time-varying-delay
#10
Shaohua Long, Shouming Zhong
This paper is concerned with the H∞ control problem for a class of singular systems. The systems under consideration involve state time-varying delay. The aim of this paper is to design a dynamic feedback controller such that the resultant closed-loop system is regular, impulse-free and stable with given H∞ performance index. By using the Lyapunov-Krasovskii functional method, some delay-dependent sufficient criteria which guarantee the existence of the dynamic feedback controller and determine explicitly the parameters of the dynamic feedback controller are presented...
January 2017: ISA Transactions
https://www.readbyqxmd.com/read/28341164/expectation-violation-and-attention-to-pain-jointly-modulate-neural-gain-in-somatosensory-cortex
#11
Francesca Fardo, Ryszard Auksztulewicz, Micah Allen, Martin J Dietz, Andreas Roepstorff, Karl J Friston
The neural processing and experience of pain are influenced by both expectations and attention. For example, the amplitude of event-related pain responses is enhanced by both novel and unexpected pain, and by moving the focus of attention towards a painful stimulus. Under predictive coding, this congruence can be explained by appeal to a precision-weighting mechanism, which mediates bottom-up and top-down attentional processes by modulating the influence of feedforward and feedback signals throughout the cortical hierarchy...
March 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/28340994/biological-effect-of-aqueous-c60-aggregates-on-scenedesmus-obliquus-revealed-by-transcriptomics-and-non-targeted-metabolomics
#12
Chunlei Du, Bo Zhang, Yiliang He, Chaoyang Hu, Qin Xiang Ng, Hui Zhang, Choon Nam Ong, ZhifenLin
This work evaluated biological effect of nC60 on Scenedesmus obliquus. The cells were exposed to various concentrations of nC60 for 7days. Low-dose of nC60 was found to have a minor growth inhibitory effect. The transcriptomics and metabolomics were integrated to examine intricate molecular and cellular effects of nC60 on Scenedesmus obliquus. We found that Scenedesmus obliquus cells exposed to nC60 had several significant alterations in cellular transcription and biochemical processes. During the 7-day exposure to nC60, 2234 and 2,448 unigenes were differentially expressed by 0...
February 15, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28340390/the-association-of-eating-performance-and-environmental-stimulation-among-older-adults-with-dementia-in-nursing-homes-a-secondary-analysis
#13
Wen Liu, Ying-Ling Jao, Kristine Williams
BACKGROUND: Nursing home residents with dementia experience increased risk for compromised eating performance due to intrapersonal, interpersonal, and environmental factors. Environmental stimulation is physical, social, and/or sensory stimulation present in the environment that can potentially trigger individuals' emotion or motivate physical reactions. Beyond the personal factors, there is a lack of evidence on how environmental stimulation influences individuals' eating performance at mealtimes...
March 9, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28340375/repetitive-tms-in-right-sensorimotor-areas-affects-the-selection-and-completion-of-contralateral-movements
#14
Maria Gutierrez-Herrera, Styrmir Saevarsson, Thomas Huber, Joachim Hermsdörfer, Waltraud Stadler
Although the existence of directional motor deficits (DMD) associated with movement planning and/or execution seems to be widely recognized, neglect and single cell studies examining their neuroanatomical foundation have produced contradictory and inconclusive findings. The present study assessed the occurrence of DMD following the application of repetitive transcranial magnetic stimulation (rTMS) over two regions, as commonly reported in the neglect literature, namely the right middle frontal gyrus (rMFG) and the right angular gyrus (rAG)...
February 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28340346/the-upsides-and-downsides-of-organelle-interconnectivity
#15
REVIEW
Daniel E Gottschling, Thomas Nyström
Interconnectivity and feedback control are hallmarks of biological systems. This includes communication between organelles, which allows them to function and adapt to changing cellular environments. While the specific mechanisms for all communications remain opaque, unraveling the wiring of organelle networks is critical to understand how biological systems are built and why they might collapse, as occurs in aging. A comprehensive understanding of all the routes involved in inter-organelle communication is still lacking, but important themes are beginning to emerge, primarily in budding yeast...
March 23, 2017: Cell
https://www.readbyqxmd.com/read/28339590/reducing-antimicrobial-use-in-an-academic-pediatric-institution-evaluation-of-the-effectiveness-of-a-prospective-audit-with-real-time-feedback
#16
Zachary I Willis, Jessica Gillon, Meng Xu, James C Slaughter, M Cecilia Di Pentima
Introduction: Antimicrobial use is decreasing across freestanding children's hospitals, predominantly in institutions with antimicrobial stewardship programs (ASPs) in place. A highly effective ASP should effect a greater decrease in use than predicted by existing trends. Antimicrobial stewardship programs depend on clinician adherence to program recommendations, but little is known about factors associated with adherence. Methods: Parenteral antimicrobial-use data for our institution and 43 additional freestanding children's hospitals were obtained and normalized for patient census...
October 7, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28338795/-mom-i-don-t-want-to-hear-it-brain-response-to-maternal-praise-and-criticism-in-adolescents-with-major-depressive-disorder
#17
Jennifer S Silk, Kyung Hwa Lee, Rosalind D Elliott, Jill M Hooley, Ronald E Dahl, Anita Barber, Greg J Siegle
Recent research has implicated altered neural response to interpersonal feedback as an important factor in adolescent depression, with existing studies focusing on responses to feedback from virtual peers. We investigated whether depressed adolescents differed from healthy youth in neural response to social evaluative feedback from mothers. During neuroimaging, twenty adolescents in a current episode of major depressive disorder (MDD) and 28 healthy controls listened to previously recorded audio clips of their own mothers' praise, criticism and neutral comments...
February 17, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/28338406/a-feasibility-study-for-improved-physical-activity-after-total-knee-arthroplasty
#18
Roger J Paxton, Jeri E Forster, Matthew J Miller, Kristine L Gerron, Jennifer E Stevens-Lapsley, Cory L Christiansen
BACKGROUND: Physical activity outcomes are poor following total knee arthroplasty (TKA). The purpose was to evaluate feasibility of a physical activity feedback intervention for patients after TKA. METHODS: Participants completing conventional TKA rehabilitation were randomized to a physical activity feedback (PAF; n=22) or control (CTL; n=23) group. The PAF intervention included real-time activity feedback, weekly action planning, and monthly group support meetings (12-weeks)...
March 24, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28337434/influence-of-power-delivery-timing-on-the-energetics-and-biomechanics-of-humans-wearing-a-hip-exoskeleton
#19
Aaron J Young, Jessica Foss, Hannah Gannon, Daniel P Ferris
A broad goal in the field of powered lower limb exoskeletons is to reduce the metabolic cost of walking. Ankle exoskeletons have successfully achieved this goal by correctly timing a plantarflexor torque during late stance phase. Hip exoskeletons have the potential to assist with both flexion and extension during walking gait, but the optimal timing for maximally reducing metabolic cost is unknown. The focus of our study was to determine the best assistance timing for applying hip assistance through a pneumatic exoskeleton on human subjects...
2017: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/28335809/poor-uptake-of-an-online-intervention-in-a-cluster-randomised-controlled-trial-of-online-diabetes-education-for-rural-general-practitioners
#20
Christine L Paul, Leon Piterman, Jonathan E Shaw, Catherine Kirby, Kristy L Forshaw, Jennifer Robinson, Isaraporn Thepwongsa, Robert W Sanson-Fisher
BACKGROUND: In Australia, rural and remote communities have high rates of diabetes-related death and hospitalisation. General practitioners (GPs) play a major role in diabetes detection and management. Education of GPs could optimise diabetes management and improve patient outcomes at a population level. The study aimed to describe the uptake of a continuing medical education intervention for rural GPs and its impact on the viability of a cluster randomised controlled trial of the effects of continuing medical education on whole-town diabetes monitoring and control...
March 23, 2017: Trials
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