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https://www.readbyqxmd.com/read/29677663/haptic-based-perception-empathy-biofeedback-system-for-balance-rehabilitation-in-patients-with-chronic-stroke-concepts-and-initial-feasibility-study
#1
Kazuhiro Yasuda, Kenta Saichi, Naomi Kaibuki, Hiroaki Harashima, Hiroyasu Iwata
BACKGROUND: Most individuals have sensory disturbances post stroke, and these deficits contribute to post-stroke balance impairment. The haptic-based biofeedback (BF) system appears to be one of the promising tools for balance rehabilitation in patients with stroke, and the BF system can increase the objectivity of feedback and encouragement than that provided by a therapist. RESEARCH QUESTION: Studies in skill science indicated that feedback or encouragement from a coach or trainer enhances motor learning effect...
April 14, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29677558/robust-generalized-mittag-leffler-synchronization-of-fractional-order-neural-networks-with-discontinuous-activation-and-impulses
#2
A Pratap, R Raja, C Sowmiya, O Bagdasar, Jinde Cao, G Rajchakit
Fractional order system is playing an increasingly important role in terms of both theory and applications. In this paper we investigate the global existence of Filippov solutions and the robust generalized Mittag-Leffler synchronization of fractional order neural networks with discontinuous activation and impulses. By means of growth conditions, differential inclusions and generalized Gronwall inequality, a sufficient condition for the existence of Filippov solution is obtained. Then, sufficient criteria are given for the robust generalized Mittag-Leffler synchronization between discontinuous activation function of impulsive fractional order neural network systems with (or without) parameter uncertainties, via a delayed feedback controller and M-Matrix theory...
April 4, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29676798/afferent-neural-feedback-overrides-the-modulating-effects-of-arousal-hypercapnia-and-hypoxemia-on-neonatal-cardio-respiratory-control
#3
Kathleen J Lumb, Jennifer M Schneider, Thowfique Ibrahim, Anita Rigaux, Shabih U Hasan
KEY POINTS: Evidence at whole animal, organ-system, and cellular and molecular levels suggests that afferent volume feedback is critical for establishment of adequate ventilation at birth. Due to the irreversible nature of vagal ablation studies to date, it was difficult to quantify the roles of afferent volume input, arousal and changes in blood gas tensions on neonatal respiratory control. During reversible perineural vagal block, profound apneas, and hypoxemia and hypercarbia were observed necessitating termination of perineural blockade...
April 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29674986/comparing-feedback-types-in-multimedia-learning-of-speech-by-young-children-with-common-speech-sound-disorders-research-protocol-for-a-pretest-posttest-independent-measures-control-trial
#4
Wendy Doubé, Paul Carding, Kieran Flanagan, Jordy Kaufman, Hannah Armitage
Children with speech sound disorders benefit from feedback about the accuracy of sounds they make. Home practice can reinforce feedback received from speech pathologists. Games in mobile device applications could encourage home practice, but those currently available are of limited value because they are unlikely to elaborate "Correct"/"Incorrect" feedback with information that can assist in improving the accuracy of the sound. This protocol proposes a "Wizard of Oz" experiment that aims to provide evidence for the provision of effective multimedia feedback for speech sound development...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29674959/meal-sensing-signaling-pathways-in-functional-dyspepsia
#5
REVIEW
Amanda J Page, Hui Li
The upper gastrointestinal tract plays an important role in sensing the arrival, amount and chemical composition of a meal. Ingestion of a meal triggers a number of sensory signals in the gastrointestinal tract. These include the response to mechanical stimulation (e.g., gastric distension), from the presence of food in the gut, and the interaction of various dietary nutrients with specific "taste" receptors on specialized enteroendocrine cells in the small intestine culminating in the release of gut hormones...
2018: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29674365/protocol-of-a-multicenter-international-randomized-controlled-manikin-study-on-different-protocols-of-cardiopulmonary-resuscitation-for-laypeople-mani-cpr
#6
Enrico Baldi, Enrico Contri, Roman Burkart, Paola Borrelli, Ottavia Eleonora Ferraro, Michela Tonani, Amedeo Cutuli, Daniele Bertaia, Pasquale Iozzo, Caroline Tinguely, Daniel Lopez, Susi Boldarin, Claudio Deiuri, Sandrine Dénéréaz, Yves Dénéréaz, Michael Terrapon, Christian Tami, Cinzia Cereda, Alberto Somaschini, Stefano Cornara, Andrea Cortegiani
INTRODUCTION: Out-of-hospital cardiac arrest is one of the leading causes of death in industrialised countries. Survival depends on prompt identification of cardiac arrest and on the quality and timing of cardiopulmonary resuscitation (CPR) and defibrillation. For laypeople, there has been a growing interest on hands-only CPR, meaning continuous chest compression without interruption to perform ventilations. It has been demonstrated that intentional interruptions in hands-only CPR can increase its quality...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29674362/implementation-of-an-evidence-based-model-of-care-for-low-back-pain-in-emergency-departments-protocol-for-the-sydney-health-partners-emergency-department-shaped-trial
#7
Gustavo C Machado, Bethan Richards, Chris Needs, Rachelle Buchbinder, Ian A Harris, Kirsten Howard, Kirsten McCaffery, Laurent Billot, James Edwards, Eileen Rogan, Rochelle Facer, David Lord Cowell, Chris G Maher
INTRODUCTION: Patients with low back pain often seek care in emergency departments, but the problem is that many patients receive unnecessary or ineffective interventions and at the same time miss out on the basics of care, such as advice on self-management. This pattern of care has important consequences for the healthcare system (expensive and inefficient) and for patients (poor health outcomes). We hypothesised that the implementation of an evidence-based model of care for low back pain will improve emergency care by reducing inappropriate overuse of tests and treatments and improving patient outcomes...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29673553/the-discoveries-of-molecular-mechanisms-for-the-circadian-rhythm-the-2017-nobel-prize-in-physiology-or-medicine
#8
Rong-Chi Huang
Circadian clocks evolved to allow plants and animals to adapt their behaviors to the 24-hr change in the external environment due to the Earth's rotation. While the first scientific observation of circadian rhythm in the plant leaf movement may be dated back to the early 18th century, it took 200 years to realize that the leaf movement is controlled by an endogenous circadian clock. The cloning and characterization of the first Drosophila clock gene period in the early 1980s, independently by Jeffery C. Hall and Michael Rosbash at Brandeis University and Michael Young at Rockefeller University, paved the way for their further discoveries of additional genes and proteins, culminating in establishing the so-called transcriptional translational feedback loop (TTFL) model for the generation of autonomous oscillator with a period of ∼24 h...
February 2018: Biomedical Journal
https://www.readbyqxmd.com/read/29673391/parenting-resilient-kids-park-an-online-parenting-program-to-prevent-anxiety-and-depression-problems-in-primary-school-aged-children-study-protocol-for-a-randomised-controlled-trial
#9
Luwishennadige Madhawee N Fernando, Wan Hua Sim, Anthony F Jorm, Ron Rapee, Katherine A Lawrence, Marie B H Yap
BACKGROUND: Preventive efforts targeting childhood anxiety and depression symptoms have the potential to alter the developmental trajectory of depression and anxiety disorders across the lifespan. Substantial previous research suggests that modifiable parenting factors such as parental aversiveness and over-involvement are associated with childhood anxiety, depressive and internalising symptoms, indicating that parents can play a critical role in prevention. The Parenting Resilient Kids study is a new evidence-based online parenting program designed to prevent anxiety and depression problems in primary school-aged children by reducing family-based risk factors and enhancing protective factors through increased positive interactions between parent and child...
April 19, 2018: Trials
https://www.readbyqxmd.com/read/29672526/structured-patient-handoff-on-an-internal-medicine-ward-a-cluster-randomized-control-trial
#10
Penny Tam, Aman P Nijjar, Mark Fok, Chris Little, Alexandra Shingina, Jesse Bittman, Rashmi Raghavan, Nadia A Khan
BACKGROUND: The effect of a multi-faceted handoff strategy in a high volume internal medicine inpatient setting on process and patient outcomes has not been clearly established. We set out to determine if a multi-faceted handoff intervention consisting of education, standardized handoff procedures, including fixed time and location for face-to-face handoff would result in improved rates of handoff compared with usual practice. We also evaluated resident satisfaction, health resource utilization and clinical outcomes...
2018: PloS One
https://www.readbyqxmd.com/read/29672027/meniscus-on-demand-parallel-3d-nanoprinting
#11
Mojun Chen, Zhaoyi Xu, Jung Hyun Kim, Seung Kwon Seol, Ji Tae Kim
Exploiting a femtoliter liquid meniscus formed on a nanopipette is a powerful approach to spatially control mass transfer or chemical reaction at the nanoscale. However, the insufficient reliability of techniques for the meniscus formation still restricts its practical use. We report on a noncontact, programmable method to produce a femtoliter liquid meniscus that is utilized for parallel three-dimensional (3D) nanoprinting. The method based on electrohydrodynamic dispensing enables one to create an ink meniscus at a pipette-substrate gap without physical contact and positional feedback...
April 19, 2018: ACS Nano
https://www.readbyqxmd.com/read/29670516/the-effects-of-fluency-enhancing-conditions-on-sensorimotor-control-of-speech-in-typically-fluent-speakers-an-eeg-mu-rhythm-study
#12
Tiffani Kittilstved, Kevin J Reilly, Ashley W Harkrider, Devin Casenhiser, David Thornton, David E Jenson, Tricia Hedinger, Andrew L Bowers, Tim Saltuklaroglu
Objective : To determine whether changes in sensorimotor control resulting from speaking conditions that induce fluency in people who stutter (PWS) can be measured using electroencephalographic (EEG) mu rhythms in neurotypical speakers. Methods : Non-stuttering (NS) adults spoke in one control condition (solo speaking) and four experimental conditions (choral speech, delayed auditory feedback (DAF), prolonged speech and pseudostuttering). Independent component analysis (ICA) was used to identify sensorimotor μ components from EEG recordings...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29670188/assessing-the-quality-of-supplementary-sensory-feedback-using-the-crossmodal-congruency-task
#13
Daniel Blustein, Adam Wilson, Jon Sensinger
Advanced neural interfaces show promise in making prosthetic limbs more biomimetic and ultimately more intuitive and useful for patients. However, approaches to assess these emerging technologies are limited in scope and the insight they provide. When outfitting a prosthesis with a feedback system, such as a peripheral nerve interface, it would be helpful to quantify its physiological correspondence, i.e. how well the prosthesis feedback mimics the perceived feedback in an intact limb. Here we present an approach to quantify this aspect of feedback quality using the crossmodal congruency effect (CCE) task...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669462/the-negative-feedback-dysregulation-effect-losses-of-motor-control-in-response-to-negative-feedback
#14
Robert J Klein, Michael D Robinson
Negative feedback has paradoxical features to it. This form of feedback can have informational value under some circumstances, but it can also threaten the ego, potentially upsetting behaviour as a result. To investigate possible consequences of the latter type, two experiments (total N = 159) presented positive or negative feedback within a sequence-prediction task that could not be solved. Following feedback, participants had to control their behaviours as effectively as possible in a motor control task...
April 19, 2018: Cognition & Emotion
https://www.readbyqxmd.com/read/29669288/mutual-stabilization-between-trim9-short-isoform-and-mkk6-potentiates-p38-signaling-to-synergistically-suppress-glioblastoma-progression
#15
Kunpeng Liu, Chuanxia Zhang, Bowen Li, Weihong Xie, Jindong Zhang, Xichen Nie, Peng Tan, Limin Zheng, Song Wu, Yunfei Qin, Jun Cui, Feng Zhi
p38 signaling is broadly involved in controlling inflammation and stress-induced cell death; however, the mechanisms controlling its activity have seldom been studied. Here, we report that TRIM9 short isoform (TRIM9s) potentiates p38 signaling by stabilizing MKK6. Mechanistic studies revealed that TRIM9s promotes the K63-linked ubiquitination of MKK6 at Lys82, thus inhibiting the degradative K48-linked ubiquitination of MKK6 at the same lysine. MKK6 could also stabilize TRIM9s by promoting the phosphorylation of TRIM9s at Ser76/80 via p38, thereby blocking the ubiquitin-proteasome pathway...
April 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/29668981/wnts-role-in-bovine-folliculogenesis-and-estrogen-production
#16
B I Gomez, B H Aloqaily, C A Gifford, D M Hallford, J A Hernandez Gifford
Appreciation of mechanisms that affect steroidogenesis is critical to identifying compromising signals that may decrease reproductive efficiency. Follicle maturation and steroidogenesis requires coordinated actions from the pituitary gonadotropins, and local ovarian signaling molecules. Beta-catenin (CTNNB1), the lynchpin molecule of canonical wingless-type mouse mammary tumor virus integration site (WNT) signaling is required for maximal gonadotropin stimulation of steroid production from granulosa (GC) and luteal cells...
April 13, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29668389/stepping-responses-to-treadmill-perturbations-vary-with-severity-of-motor-deficits-in-human-sci
#17
Virginia Way Tong Chu, T George Hornby, Brian D Schmit
In this study, we investigated the responses to tread perturbations during human stepping on a treadmill. Our approach was to test the effects of perturbations to a single leg using a split-belt treadmill in healthy participants and in participants with varying severity of spinal cord injury (SCI). We recruited 11 people with incomplete SCI and 5 noninjured participants. As participants walked on an instrumented treadmill, the belt on one side was stopped or accelerated briefly during mid to late stance. A majority of participants initiated an unnecessary swing when the treadmill was stopped in mid stance, although the likelihood of initiating a step was decreased in participants with more severe SCI...
April 18, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29668382/the-cross-education-of-strength-and-skill-following-unilateral-strength-training-in-the-upper-and-lower-limbs
#18
Lara A Green, David A Gabriel
Cross education is the strength gain or skill improvement transferred to the contralateral limb following unilateral training or practice. The present study examined the transfer of both strength and skill following a strength training program. Forty participants (20M, 20F) completed a 6-week unilateral training program of dominant wrist flexion or dorsiflexion. Strength, force variability, and muscle activity were assessed pre-training, post-training, and following 6-weeks of detraining (retention). Analyses of covariance compared the experimental limb (trained or untrained) to the control (dominant or non-dominant)...
April 18, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29668325/is-cushing-mechanism-a-dynamic-blood-pressure-stabilizing-system-insights-from-granger-causality-analysis-of-spontaneous-blood-pressure-and-cerebral-blood-flow
#19
Saqib Saleem, Paul D Teal, Connor A Howe, Michael M Tymko, Philip N Ainslie, Yu-Chieh Tzeng
Blood pressure regulation is widely recognised as being integral to the control of end-organ perfusion but it remains unclear whether end-organ perfusion also plays a role in driving changes in blood pressure (BP). A randomized and placebo controlled study design was followed to examine the feedback relationships between very-low-frequency fluctuations in BP and cerebral blood flow (CBF) in humans under placebo treatment and α1-adrenergic blockade. To determine the causal relations among haemodynamic variables, BP, middle cerebral artery blood velocity (MCAv), and end-tidal CO2 time-series were decimated, low-pass filtered (<0...
April 18, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29667908/the-macula-densa-prorenin-receptor-is-essential-in-renin-release-and-blood-pressure-control
#20
Anne D M Riquier-Brison, Arnold Sipos, Ágnes Prókai, Sarah L Vargas, Ildiko Toma, Elliott J Meer, Karie G Villanueva, Jennifer C M Chen, Georgina Gyarmati, Christopher Yih, Elaine Tang, Bahram Nadim, Sujith Pendekanti, Ingrid M Garrelds, Genevieve Nguyen, A H Jan Danser, Janos Peti-Peterdi
The prorenin receptor (PRR) was originally proposed to be a member of the renin-angiotensin system (RAS), however recent work questioned their association. The present paper describes a functional link between the PRR and RAS in the renal juxtaglomerular apparatus (JGA), a classic anatomical site of the RAS. PRR expression was found in the sensory cells of the JGA, the macula densa (MD), and immunohistochemistry localized PRR to the MD basolateral cell membrane in mouse, rat, and human kidneys. MD cell PRR activation led to MAP kinase ERK1/2 signaling and stimulation of PGE2 release, the classic pathway of MD-mediated renin release...
April 18, 2018: American Journal of Physiology. Renal Physiology
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