keyword
MENU ▼
Read by QxMD icon Read
search

feed-forward

keyword
https://www.readbyqxmd.com/read/29330945/cyclosporine-a-induces-endothelin-converting-enzyme-ece-1-studies-in-vivo-and-in-vitro
#1
Samuel N Heyman, Zaid Abassi, Christian Rosenberger, Hiba Yaseen, Galia Skarjinski, Ahuva Shina, Susanne Mathia, Natalia Krits, Mogher Khamaisi
AIM: Cyclosporine A (CsA) induces renal vasoconstriction and hypoxia and enhances the expression of endothelin-1 (ET-1) pro-hormone (pre-pro ET-1), plausibly leading to a feed-forward loop of renal vasoconstriction, hypoxia, and enhanced synthesis of the potent vasoconstrictor ET-1. Endothelin converting enzyme (ECE)-1 cleaves big endothelin to generate endothelin (ET)-1 and is up-regulated by hypoxia via hypoxia-inducible factor (HIF). We hypothesized that in addition to the direct induction of ET-1 synthesis, CsA might also intensify renal ECE-1expression, thus contributing to enhanced ET-1 synthesis following CsA...
January 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29330773/mechanistic-regulation-of-epithelial-to-mesenchymal-transition-through-ras-signaling-pathway-and-therapeutic-implications-in-human-cancer
#2
REVIEW
Kiran Tripathi, Minal Garg
RAS effector signaling instead of being simple, unidirectional and linear cascade, is actually recognized as highly complex and dynamic signaling network. RAF-MEK-ERK cascade, being at the center of complex signaling network, links to multiple scaffold proteins through feed forward and feedback mechanisms and dynamically regulate tumor initiation and progression. Three isoforms of Ras harbor mutations in a cell and tissue specific manner. Besides mutations, their epigenetic silencing also attributes them to exhibit oncogenic activities...
January 12, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29330456/20-hete-promotes-glucose-stimulated-insulin-secretion-in-an-autocrine-manner-through-ffar1
#3
Sorin Tunaru, Remy Bonnavion, Isabell Brandenburger, Jens Preussner, Dominique Thomas, Klaus Scholich, Stefan Offermanns
The long-chain fatty acid receptor FFAR1 is highly expressed in pancreatic β-cells. Synthetic FFAR1 agonists can be used as antidiabetic drugs to promote glucose-stimulated insulin secretion (GSIS). However, the physiological role of FFAR1 in β-cells remains poorly understood. Here we show that 20-HETE activates FFAR1 and promotes GSIS via FFAR1 with higher potency and efficacy than dietary fatty acids such as palmitic, linoleic, and α-linolenic acid. Murine and human β-cells produce 20-HETE, and the ω-hydroxylase-mediated formation and release of 20-HETE is strongly stimulated by glucose...
January 12, 2018: Nature Communications
https://www.readbyqxmd.com/read/29321164/kras-oncoprotein-expression-is-regulated-by-a-self-governing-eif5a-peak1-feed-forward-regulatory-loop
#4
Ken Fujimura, Huawei Wang, Felicia Watson, Richard L Klemke
There remains intense interest in tractable approaches to target or silence the KRAS oncoprotein as a rational therapeutic strategy to attack pancreatic adenocarcinoma (PDAC) and other cancers which overexpress it. Here we provide evidence that accumulation of the KRAS oncoprotein is controlled by a self-regulating feed-forward regulatory loop that utilizes a unique hypusinated isoform of the translation elongation factor eIF5A and the tyrosine kinase PEAK1. Oncogenic activation of KRAS increased eIF5A-PEAK1 translational signaling, which in turn facilitated increased KRAS protein synthesis...
January 10, 2018: Cancer Research
https://www.readbyqxmd.com/read/29311615/hoxc5-and-mir-615-3p-target-newly-evolved-genomic-regions-to-repress-htert-and-inhibit-tumorigenesis
#5
TingDong Yan, Wen Fong Ooi, Aditi Qamra, Alice Cheung, DongLiang Ma, Gopinath Meenakshi Sundaram, Chang Xu, Manjie Xing, LaiFong Poon, Jing Wang, Yan Ping Loh, Jess Hui Jie Ho, Joscelyn Jun Quan Ng, Muhammad Khairul Ramlee, Luay Aswad, Steve G Rozen, Sujoy Ghosh, Frederic A Bard, Prabha Sampath, Vinay Tergaonkar, James O J Davies, Jim R Hughes, Eyleen Goh, Xuezhi Bi, Melissa Jane Fullwood, Patrick Tan, Shang Li
The repression of telomerase activity during cellular differentiation promotes replicative aging and functions as a physiological barrier for tumorigenesis in long-lived mammals, including humans. However, the underlying mechanisms remain largely unclear. Here we describe how miR-615-3p represses hTERT expression. mir-615-3p is located in an intron of the HOXC5 gene, a member of the highly conserved homeobox family of transcription factors controlling embryogenesis and development. Unexpectedly, we found that HoxC5 also represses hTERT expression by disrupting the long-range interaction between hTERT promoter and its distal enhancer...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29305708/identification-of-specific-feed-forward-apoptosis-mechanisms-and-associated-higher-survival-rates-for-low-grade-glioma-and-lung-squamous-cell-carcinoma
#6
Dhiraj Sikaria, Yaping N Tu, Diana A Fisler, James A Mauro, George Blanck
The mechanisms of cell proliferation due to the overexpression of certain transcription factors (TFs) have been well documented in the cancer setting. However, many of these same TFs have pro-apoptotic effects, particularly when expressed or activated at high levels, a process referred to as feed-forward apoptosis (FFA). To determine whether cancers could be stratified on the basis of specific FFA signatures, RNASeq data representing samples from the cancer genome atlas were analyzed, revealing that high expression of the pro-proliferative TFs, MYC and YY1, is associated with a favorable outcome in low-grade glioma (LGG) and lung squamous cell carcinoma (LUSC), respectively...
January 5, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29300432/falls-risk-prediction-for-older-inpatients-in-acute-care-medical-wards-is-there-an-interest-to-combine-an-early-nurse-assessment-and-the-artificial-neural-network-analysis
#7
O Beauchet, F Noublanche, R Simon, H Sekhon, J Chabot, E J Levinoff, A Kabeshova, C P Launay
BACKGROUND: Identification of the risk of falls is important among older inpatients. This study aims to examine performance criteria (i.e.; sensitivity, specificity, positive predictive value, negative predictive value and accuracy) for fall prediction resulting from a nurse assessment and an artificial neural networks (ANNs) analysis in older inpatients hospitalized in acute care medical wards. METHODS: A total of 848 older inpatients (mean age, 83.0±7.2 years; 41...
2018: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29282304/type-2-cysteinyl-leukotriene-receptors-drive-il-33-dependent-type-2-immunopathology-and-aspirin-sensitivity
#8
Tao Liu, Nora A Barrett, Yoshihide Kanaoka, Eri Yoshimoto, Denise Garofalo, Haley Cirka, Chunli Feng, Joshua A Boyce
Cysteinyl leukotrienes (cysLTs) facilitate mucosal type 2 immunopathology by incompletely understood mechanisms. Aspirin-exacerbated respiratory disease, a severe asthma subtype, is characterized by exaggerated eosinophilic respiratory inflammation and reactions to aspirin, each involving the marked overproduction of cysLTs. Here we demonstrate that the type 2 cysLT receptor (CysLT2R), which is not targeted by available drugs, is required in two different models to amplify eosinophilic airway inflammation via induced expression of IL-33 by lung epithelial cells...
December 27, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29280391/development-of-a-new-esomeprazole-delayed-release-gastro-resistant-pellet-formulation-with-improved-storage-stability
#9
Panagiotis Barmpalexis, Agni Grypioti
The present study describes the development of a new esomeprazole (ESO) delayed release gastro-resistant formulation with improved storage stability. A three step (drug-, sub(seal)- and enteric-) coating process was employed with the aid of a fluid bed coater. Several formulation factors (namely size and quantity of starting non-pareil sugar spheres, binder quantity during drug-layering, sub(seal)-coating polymer type and quantity and enteric coating quantity) were evaluated and the whole process was modelled with the aid of feed-forward back-propagation artificial neural networks (ANNs)...
December 27, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29259132/histone-deacetylase-6-hdac6-deacetylates-extracellular-signal-regulated-kinase-1-erk1-and-thereby-stimulates-erk1-activity
#10
Jheng-Yu Wu, Shengyan Xiang, Mu Zhang, Bin Fang, He Huang, Oh Kwang Kwon, Yingming Zhao, Zhe Yang, Wenlong Bai, Gerold Bepler, Xiaohong Mary Zhang
Histone deacetylase 6 (HDAC6), a class IIb HDAC, plays an important role in many biological and pathological processes. Previously, we found that ERK1, a downstream kinase in the MAPK signaling pathway, phosphorylates HDAC6, thereby increasing HDAC6-mediated deacetylation of α-tubulin. However, whether HDAC6 reciprocally modulates ERK1 activity is unknown. Here, we report that both ERK1 and 2 are acetylated and that HDAC6 promotes ERK1 activity via deacetylation. Briefly, we found that both ERK1 and 2 physically interact with HDAC6...
December 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29249342/predictions-of-ocular-changes-caused-by-diabetes-in-glaucoma-patients
#11
Nicoleta Anton Apreutesei, Filip Tircoveanu, Alina Cantemir, Camelia Bogdanici, Cătălin Lisa, Silvia Curteanu, Dorin Chiseliţă
BACKGROUND AND OBJECTIVE: This paper builds different neural network models with simple topologies, having one or two hidden layers which were subsequently employed in the prediction of ocular changes progression in patients with diabetes associated with primer open-angle glaucoma. MATERIAL AND METHODS: For attempting to indicate whether there is a relationship between glaucoma and diabetes, a simulation method, based on artificial neural networks (ANN), Jordan Elman networks (JEN) type, in particular, was applied in conjunction with clinical observation...
February 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29226965/brain-reflections-a-circuit-based-framework-for-understanding-information-processing-and-cognitive-control
#12
Gabriele Gratton
Here, I propose a view of the architecture of the human information processing system, and of how it can be adapted to changing task demands (which is the hallmark of cognitive control). This view is informed by an interpretation of brain activity as reflecting the excitability level of neural representations, encoding not only stimuli and temporal contexts, but also action plans and task goals. The proposed cognitive architecture includes three types of circuits: open circuits, involved in feed-forward processing such as that connecting stimuli with responses and characterized by brief, transient brain activity; and two types of closed circuits, positive feedback circuits (characterized by sustained, high-frequency oscillatory activity), which help select and maintain representations, and negative feedback circuits (characterized by brief, low-frequency oscillatory bursts), which are instead associated with changes in representations...
December 11, 2017: Psychophysiology
https://www.readbyqxmd.com/read/29224674/drivers-of-the-immunopathogenesis-in-systemic-lupus-erythematosus
#13
REVIEW
Thomas Rose, Thomas Dörner
This review summarises a number of current insights into the pathogenesis of SLE. On the basis of the interaction of environmental factors within a predisposed host, a chronic autoimmune process gains function with a positive feed-forward loop between innate and adaptive immunity. A current focus of SLE pathogenesis is on the enhanced production of certain cytokines, such as type I interferons and BLyS/BAFF, suggesting continuous plasmacytoid dendritic and myeloid cell activity together with disturbances of B lineage cells (increased autoantibodies, including anti-dsDNA and plasmablasts, which correlate with SLE activity and memory B-cell abnormalities)...
June 2017: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/29222490/ran-translation-at-c9orf72-associated-repeat-expansions-is-selectively-enhanced-by-the-integrated-stress-response
#14
Katelyn M Green, M Rebecca Glineburg, Michael G Kearse, Brittany N Flores, Alexander E Linsalata, Stephen J Fedak, Aaron C Goldstrohm, Sami J Barmada, Peter K Todd
Repeat-associated non-AUG (RAN) translation allows for unconventional initiation at disease-causing repeat expansions. As RAN translation contributes to pathogenesis in multiple neurodegenerative disorders, determining its mechanistic underpinnings may inform therapeutic development. Here we analyze RAN translation at G4C2 repeat expansions that cause C9orf72-associated amyotrophic lateral sclerosis and frontotemporal dementia (C9RAN) and at CGG repeats that cause fragile X-associated tremor/ataxia syndrome...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29218420/an-improved-pathological-brain-detection-system-based-on-two-dimensional-pca-and-evolutionary-extreme-learning-machine
#15
Deepak Ranjan Nayak, Ratnakar Dash, Banshidhar Majhi
Pathological brain detection has made notable stride in the past years, as a consequence many pathological brain detection systems (PBDSs) have been proposed. But, the accuracy of these systems still needs significant improvement in order to meet the necessity of real world diagnostic situations. In this paper, an efficient PBDS based on MR images is proposed that markedly improves the recent results. The proposed system makes use of contrast limited adaptive histogram equalization (CLAHE) to enhance the quality of the input MR images...
December 7, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/29213235/changes-in-predictive-task-switching-with-age-and-with-cognitive-load
#16
Shelly Levy-Tzedek
Predictive control of movement is more efficient than feedback-based control, and is an important skill in everyday life. We tested whether the ability to predictively control movements of the upper arm is affected by age and by cognitive load. A total of 63 participants were tested in two experiments. In both experiments participants were seated, and controlled a cursor on a computer screen by flexing and extending their dominant arm. In Experiment 1, 20 young adults and 20 older adults were asked to continuously change the frequency of their horizontal arm movements, with the goal of inducing an abrupt switch between discrete movements (at low frequencies) and rhythmic movements (at high frequencies)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29213232/stress-induced-chronic-visceral-pain-of-gastrointestinal-origin
#17
REVIEW
Beverley Greenwood-Van Meerveld, Anthony C Johnson
Visceral pain is generally poorly localized and characterized by hypersensitivity to a stimulus such as organ distension. In concert with chronic visceral pain, there is a high comorbidity with stress-related psychiatric disorders including anxiety and depression. The mechanisms linking visceral pain with these overlapping comorbidities remain to be elucidated. Evidence suggests that long term stress facilitates pain perception and sensitizes pain pathways, leading to a feed-forward cycle promoting chronic visceral pain disorders such as irritable bowel syndrome (IBS)...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/29209747/an-adverse-outcome-pathway-for-parkinsonian-motor-deficits-associated-with-mitochondrial-complex-i-inhibition
#18
REVIEW
Andrea Terron, Anna Bal-Price, Alicia Paini, Florianne Monnet-Tschudi, Susanne Hougaard Bennekou, Marcel Leist, Stefan Schildknecht
Epidemiological studies have observed an association between pesticide exposure and the development of Parkinson's disease, but have not established causality. The concept of an adverse outcome pathway (AOP) has been developed as a framework for the organization of available information linking the modulation of a molecular target [molecular initiating event (MIE)], via a sequence of essential biological key events (KEs), with an adverse outcome (AO). Here, we present an AOP covering the toxicological pathways that link the binding of an inhibitor to mitochondrial complex I (i...
December 5, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/29205362/anti-oncostatin-m-antibody-inhibits-the-pro-malignant-effects-of-oncostatin-m-receptor-over-expression-in-squamous-cell-carcinoma
#19
Justyna A Kucia-Tran, Valtteri Tulkki, Cinzia G Scarpini, Stephen Smith, Maja Wallberg, Marta Paez-Ribes, Angela M Araujo, Jan Botthoff, Maria Feeney, Katherine Hughes, Maria M Caffarel, Nicholas Coleman
The oncostatin M receptor (OSMR) shows frequent gene copy-number gain and over-expression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the major ligand OSM induces multiple pro-malignant effects, including invasion, secretion of angiogenic factors and metastasis. Here we demonstrate, for the first time, that OSMR over-expression in SCC cells activates cell-autonomous feed-forward signalling, via further expression of OSMR and OSM and sustained STAT3 activation despite expression of the negative regulator SOCS3...
December 4, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29201944/bystander-effects-of-nitric-oxide-in-anti-tumor-photodynamic-therapy
#20
Jerzy Bazak, Jonathan M Fahey, Katarzyna Wawak, Witold Korytowski, Albert W Girotti
Ionizing radiation of specifically targeted cells in a given population is known to elicit pro-death or pro-survival responses in non-targeted bystander cells, which often make no physical contact with the targeted ones. We have recently demonstrated a similar phenomenon for non-ionizing photodynamic therapy (PDT), showing that prostate cancer cells subjected to targeted photodynamic stress stimulated growth and migration of non-stressed, non-contacting bystander cells. Diffusible nitric oxide (NO) generated by stress-upregulated inducible nitric oxide synthase (iNOS) was shown to play a dominant role in these responses...
2017: Cancer Cell & Microenvironment
keyword
keyword
88989
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"