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https://www.readbyqxmd.com/read/28628529/appraising-viral-load-thresholds-and-adherence-support-recommendations-in-the-world-health-organization-guidelines-for-detection-and-management-of-virologic-failure
#1
Suzanne M McCluskey, Yap Boum, Nicholas Musinguzi, Jessica E Haberer, Jeffrey N Martin, Peter W Hunt, Vincent C Marconi, David R Bangsberg, Mark J Siedner
BACKGROUND: The World Health Organization defines HIV virologic failure as two consecutive viral loads >1,000 copies/mL, measured 3-6 months apart with interval adherence support. We sought to empirically evaluate these guidelines using data from an observational cohort. SETTING: The Uganda AIDS Rural Treatment Outcomes study observed adults with HIV in southwestern Uganda from the time of antiretroviral therapy (ART) initiation, and monitored adherence with electronic pill bottles...
June 15, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28600469/classic-spotlight-1992-and-1993-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#2
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
July 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28598903/self-reported-difficulties-with-everyday-function-cognitive-symptoms-and-cognitive-function-in-people-with-hiv
#3
Rosanna Laverick, Lewis Haddow, Marina Daskalopoulou, Fiona Lampe, Richard Gilson, Andrew Speakman, Andrea Antinori, Tina Bruun, Anna Vassilenko, Simon Collins, Alison Rodger
BACKGROUND: We determined factors associated with self-reported decline in activities of daily living (ADLs) and symptoms of cognitive impairment in HIV positive (HIV+) adults in five European clinics. METHODS: HIV+ adults underwent computerized and pen-and-paper neuropsychological tests and questionnaires of cognitive symptoms and ADLs. We considered cognitive function in five domains, psychosocial factors and clinical parameters as potentially associated with symptoms...
June 7, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28585310/direct-acting-antivirals-for-chronic-hepatitis-c
#4
REVIEW
Janus C Jakobsen, Emil Eik Nielsen, Joshua Feinberg, Kiran Kumar Katakam, Kristina Fobian, Goran Hauser, Goran Poropat, Snezana Djurisic, Karl Heinz Weiss, Milica Bjelakovic, Goran Bjelakovic, Sarah Louise Klingenberg, Jian Ping Liu, Dimitrinka Nikolova, Ronald L Koretz, Christian Gluud
BACKGROUND: Millions of people worldwide suffer from hepatitis C, which can lead to severe liver disease, liver cancer, and death. Direct-acting antivirals (DAAs) are relatively new and expensive interventions for chronic hepatitis C, and preliminary results suggest that DAAs may eradicate hepatitis C virus (HCV) from the blood (sustained virological response). However, it is still questionable if eradication of hepatitis C virus in the blood eliminates hepatitis C in the body, and improves survival and leads to fewer complications...
June 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28550112/classic-spotlight-1990-and-1991-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#5
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
June 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28548882/finding-conducting-and-nurturing-science-a-virologist-s-memoir
#6
Anna Marie Ann Skalka Skalka
My laboratory investigations have been driven by an abiding interest in understanding the consequences of genetic rearrangement in evolution and disease, and in using viruses to elucidate fundamental mechanisms in biology. Starting with bacteriophages and moving to the retroviruses, my use of the tools of genetics, molecular biology, biochemistry, and biophysics has spanned more than half a century-from the time when DNA structure was just discovered to the present day of big data and epigenetics. Both riding and contributing to the successive waves of technology, my laboratory has elucidated fundamental mechanisms in DNA replication, repair, and recombination...
May 26, 2017: Annual Review of Virology
https://www.readbyqxmd.com/read/28548881/constraints-drivers-and-implications-of-influenza-a-virus-reassortment
#7
Anice C Lowen
Influenza A viruses are constantly changing. This change accounts for seasonal epidemics, infrequent pandemics, and zoonotic outbreaks. A major mechanism underlying the genetic diversification of influenza A virus is reassortment of intact gene segments between coinfecting viruses. This exchange is possible because of the segmented nature of the viral genome. Here, I first consider the constraints and drivers acting on influenza A virus reassortment, including the likelihood of coinfection at the host and cellular levels, mixing and assembly of heterologous gene segments within coinfected cells, and the fitness associated with reassortant genotypes...
May 26, 2017: Annual Review of Virology
https://www.readbyqxmd.com/read/28500066/classic-spotlight-1988-and-1989-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#8
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
June 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28455353/classic-spotlight-1986-and-1987-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#9
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
May 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28443981/mapping-the-dengue-scientific-landscape-worldwide-a-bibliometric-and-network-analysis
#10
Fabio Batista Mota, Bruna de Paula Fonseca E Fonseca, Andréia Cristina Galina, Roseli Monteiro da Silva
BACKGROUND: Despite the current global trend of reduction in the morbidity and mortality of neglected diseases, dengue's incidence has increased and occurrence areas have expanded. Dengue also persists as a scientific and technological challenge since there is no effective treatment, vaccine, vector control or public health intervention. Combining bibliometrics and social network analysis methods can support the mapping of dengue research and development (R&D) activities worldwide. OBJECTIVES: The aim of this paper is to map the scientific scenario related to dengue research worldwide...
May 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28408610/classic-spotlight-1984-and-1985-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#11
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28356495/classic-spotlight-1982-and-1983-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#12
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28346233/clinical-efficacy-and-tolerability-of-direct-acting-antivirals-in-elderly-patients-with-chronic-hepatitis-c
#13
Jagannath M Sherigar, Vijay Gayam, Arifa Khan, Osama Mukhtar, Yavgeniy Arefiev, Mazin Khalid, Imran Siddiqui, Ayyappa M Rangaraju, Nibash Budhathoki, Mohammed Mansour, Debra Guss, Smruti R Mohanty
BACKGROUND: There is a lack of evidence-based data on aged patients with newer direct-acting antivirals (DAAs) and with shorter duration of treatment regimens involving DAAs with or without ribavirin (RBV) and pegylated interferon (Peg IFN). PATIENTS AND METHODS: Medical records of 240 patients treated with DAAs with or without Peg IFN and RBV between January 2013 and July 2015 were retrospectively analyzed. Patients were divided into two groups: patients aged 65 years and older (N=84) and patients aged younger than 65 years (N=156)...
July 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28289234/classic-spotlight-1980-and-1981-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#14
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28272163/real-world-efficacy-of-daclatasvir-and-sofosbuvir-with-and-without-ribavirin-in-hiv-hcv-coinfected-patients-with-advanced-liver-disease-in-a-french-early-access-cohort
#15
Karine Lacombe, Hélène Fontaine, Catherine Dhiver, Sophie Metivier, Eric Rosenthal, Teresa Antonini, Marc Antoine Valantin, Patrick Miailhes, Stanislas Harent, Dominique Batisse, Georges-Philippe Pageaux, Julie Chas, Hugues Aumaitre, Stephanie Dominguez, Thierry Allegre, Alain Lafeuillade, Eric Billaud, Pierre De Truchis, Philippe Perre, Vincent Leroy, Victor De Ledinghen, Philippe Sogni, François Dabis, Yue Zhao, Anne Filipovics, Larysa Fedchuk, Raoudha Akremi, Yacia Bennai, Dominique Salmon Ceron
BACKGROUND: Efficacious, well-tolerated, direct antiviral agents have drastically changed the prognosis of hepatitis C virus (HCV) disease, but real-world data for oral treatments are limited in key populations such as HIV/HCV coinfection with advanced liver disease. Daclatasvir (DCV) efficacy and safety was assessed in the French "Autorisation Temporaire d'Utilisation" (ATU) program, providing DCV ahead of market authorization to patients with advanced HCV disease without other treatment options...
May 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28246367/classic-spotlight-1978-and-1979-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28246142/evaluating-the-effectiveness-impact-and-safety-of-live-attenuated-and-seasonal-inactivated-influenza-vaccination-protocol-for-the-seasonal-influenza-vaccination-effectiveness-ii-sive-ii-study
#17
Colin R Simpson, Nazir I Lone, Kimberley Kavanagh, Chris Robertson, Jim McMenamin, Beatrix von Wissmann, Eleftheria Vasileiou, Chris Butler, Lewis D Ritchie, Rory Gunson, Jürgen Schwarze, Aziz Sheikh
INTRODUCTION: Seasonal (inactivated) influenza vaccination is recommended for all individuals aged 65+ and in individuals under 65 who are at an increased risk of complications of influenza infection, for example, people with asthma. Live attenuated influenza vaccine (LAIV) was recommended for children as they are thought to be responsible for much of the transmission of influenza to the populations at risk of serious complications from influenza. A phased roll-out of the LAIV pilot programme began in 2013/2014...
February 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/28218575/journal-of-general-virology-introduction-to-ictv-virus-taxonomy-profiles
#18
Andrew J Davison
No abstract text is available yet for this article.
January 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28206852/british-journal-of-biomedical-science-in-2016-what-have-we-learned
#19
Andrew Blann
In 2016, the British Journal of Biomedical Science published 36 reports outlining specific advances in each of the various disciplines within biomedical science. These were one review, 25 original articles, 9 'In Brief' reports and one letter to the Editor. Of these, the majority were in blood science (5 in biochemistry, 7 in haematology and 2 in immunology) and infection science (8 in microbiology, 2 in virology) with a smaller number in cellular sciences (6 in cellular pathology and 2 in cytopathology). Three reports considered both biochemistry and immunology, while another reported an advance in the identification of chromosomal abnormalities...
January 2017: British Journal of Biomedical Science
https://www.readbyqxmd.com/read/28196923/classic-spotlight-1976-and-1977-articles-of-significant-interest-selected-from-the-journal-of-virology-archives-by-the-editors
#20
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 1, 2017: Journal of Virology
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