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post part haemorrhage

M Z Mahmoud, M Alkhorayef, A Sulieman
Objective: This study was designed with an aim to visualize the status of the posterior portion of the eye globe of adult Saudi cataract patients with brightness mode (B-mode) ultrasound, to find out any posterior segment lesions in such preoperative cases. Methods: A prospective study was performed between May 2014 and May 2015. A 375 pre-operative cataract (184, 49.1%) males and (191, 50.9%) females between the ages from 18 to 90 years; mean age of 54 ± 0.5 years were scanned at two Radiology Departments...
February 15, 2016: West Indian Medical Journal
Lesley J Scott
Tetravalent, live-attenuated, dengue vaccine (Dengvaxia(®); CYD-TDV) is the first vaccine approved for the prevention of dengue disease caused by dengue virus (DENV) serotypes 1-4 in individuals aged 9-45 or 9-60 years living in high dengue endemic areas. This narrative review discusses the immunogenicity, protective efficacy, reactogenicity and safety of CYD-TDV in the prevention of dengue disease. In Latin American and Asian phase 3 trials in children and adolescents (n > 30,000), the recommended three-dose CYD-TDV regimen was efficacious in preventing virologically-confirmed dengue (VCD) during the period from 28 days after the last dose (month 13) to month 25, meeting the primary endpoint criteria...
September 2016: Drugs
Kavita Yadav, Akanksha Singh, Ashok Kumar Jaryal, Poonam Coshic, Kabita Chatterjee, K K Deepak
Non-hypotensive hypovolemia, observed during mild haemorrhage or blood donation leads to reflex readjustment of the cardiac autonomic tone. In the present study, the cardiac autonomic tone was quantified using heart rate and blood pressure variability during and after non-hypotensive hypovolemia of blood donation. 86 voluntary healthy male blood donors were recruited for the study (age 35 ± 9 years; weight 78 ± 12 kg; height 174 ± 6 cms). Continuous lead II ECG and beat-to-beat blood pressure was recorded before, during and after blood donation followed by offline time and frequency domain analysis of HRV and BPV...
August 2, 2016: Journal of Clinical Monitoring and Computing
A S Ducloy-Bouthors, A Duhamel, E Kipnis, A Tournoys, A Prado-Dupont, A Elkalioubie, E Jeanpierre, G Debize, E Peynaud-Debayle, D DeProst, C Huissoud, A Rauch, S Susen
BACKGROUND: Beneficial effects of tranexamic acid (TA) have been established in surgery and trauma. In ongoing postpartum haemorrhage (PPH), a moderate reduction of blood loss was observed in a previously published randomized controlled trial. Analysis of haemostasis parameters obtained from samples collected as part of this study are presented. METHODS: Women with PPH >800 ml after vaginal delivery were assigned to receive either TA (4 g over 1 h, then 1 g per h over six h) (TA) or not (H)...
May 2016: British Journal of Anaesthesia
Angelika Mennecke, Stanislav Svergun, Bernhard Scholz, Kevin Royalty, Arnd Dörfler, Tobias Struffert
OBJECTIVES: Metal artefacts can impair accurate diagnosis of haemorrhage using flat detector CT (FD-CT), especially after aneurysm coiling. Within this work we evaluate a prototype metal artefact reduction algorithm by comparison of the artefact-reduced and the non-artefact-reduced FD-CT images to pre-treatment FD-CT and multi-slice CT images. METHODS: Twenty-five patients with acute aneurysmal subarachnoid haemorrhage (SAH) were selected retrospectively. FD-CT and multi-slice CT before endovascular treatment as well as FD-CT data sets after treatment were available for all patients...
April 16, 2016: European Radiology
Esther Cathyln Atukunda, Godfrey Rwambuka Mugyenyi, Celestino Obua, Elly Bronney Atuhumuza, Nicholas Musinguzi, Yarine Fajardo Tornes, Amon Ganaafa Agaba, Mark Jacob Siedner
BACKGROUND: Accurate estimation of blood loss is central to prompt diagnosis and management of post-partum hemorrhage (PPH), which remains a leading cause of maternal mortality in low-resource countries. In such settings, blood loss is often estimated visually and subjectively by attending health workers, due to inconsistent availability of laboratory infrastructure. We evaluated the diagnostic accuracy of weighed blood loss (WBL) versus changes in peri-partum hemoglobin to detect PPH...
2016: PloS One
Gary P Morris, Amanda L Wright, Richard P Tan, Amadeus Gladbach, Lars M Ittner, Bryce Vissel
The intraluminal filament model of middle cerebral artery occlusion (MCAO) in mice and rats has been plagued by inconsistency, owing in part to the multitude of variables requiring control. In this study we investigated the impact of several major variables on survival rate, lesion volume, neurological scores, cerebral blood flow (CBF) and body weight including filament width, time after reperfusion, occlusion time and the choice of surgical method. Using the Koizumi method, we found ischemic injury can be detected as early as 30 min after reperfusion, to a degree that is not statistically different from 24 h post-perfusion, using 2,3,5-Triphenyltetrazolium chloride (TTC) staining...
2016: PloS One
Raj N Kalaria, Rufus Akinyemi, Masafumi Ihara
The global burden of ischaemic strokes is almost 4-fold greater than haemorrhagic strokes. Current evidence suggests that 25-30% of ischaemic stroke survivors develop immediate or delayed vascular cognitive impairment (VCI) or vascular dementia (VaD). Dementia after stroke injury may encompass all types of cognitive disorders. States of cognitive dysfunction before the index stroke are described under the umbrella of pre-stroke dementia, which may entail vascular changes as well as insidious neurodegenerative processes...
May 2016: Biochimica et Biophysica Acta
Felix Sayinzoga, Leon Bijlmakers, Jeroen van Dillen, Victor Mivumbi, Fidèle Ngabo, Koos van der Velden
OBJECTIVE: Presenting the results of 5 years of implementing health facility-based maternal death audits in Rwanda, showing maternal death classification, identification of substandard (care) factors that have contributed to death, and conclusive recommendations for quality improvements in maternal and obstetric care. DESIGN: Nationwide facility-based retrospective cohort study. SETTINGS: All cases of maternal death audited by district hospital-based audit teams between January 2009 and December 2013 were reviewed...
2016: BMJ Open
A Kovitvadhi, F Gai, S Dabbou, I Ferrocino, L Rotolo, M Falzone, C Vignolini, M S Gennero, S Bergagna, Daniela Dezzutto, R Barbero, P Nebbia, S Rosati, L Cocolin, I Zoccarato, L Gasco
Echinacea pallida (EPAL), a herbaceous flowering plant with immunomodulatory properties, has been chosen to determine the pre- and post-supplementary effects on the growth performances, bacterial community, blood parameters and immunity of growing rabbits. The same Grimaud does (14-week-old) from the studied in the first part of this study were randomly divided into two groups (n=50/group). The first group was fed a basal diet without supplementation (Control group, C) while the another group was fed a basal diet supplemented with 3 g EPAL/kg diet (Echinacea group, E)...
July 2016: Animal: An International Journal of Animal Bioscience
R Gray, F Baldwin, S Bruemmer-Smith
UNLABELLED: A previously fit and well 57-year-old gentleman who had recently undergone a colonoscopy and biopsy of a polyp presented with a 4-day history of progressive breathlessness and abdominal discomfort. The day after admission, he became haemodynamically unstable, developed ischaemic legs and suffered a brief cardiac arrest. Blood tests demonstrated a coagulopathy and hypoglycaemia. Continued haemodynamic instability post-arrest and clinical findings of high right-sided heart pressures were investigated by bedside screening echocardiogram...
March 1, 2015: Echo Research and Practice
Abdullah Pandor, Daniel Pollard, Tim Chico, Robert Henderson, Matt Stevenson
As part of its Single Technology Appraisal process, the National Institute for Health and Care Excellence (NICE) invited the company that manufactures rivaroxaban (Xarelto, Bayer) to submit evidence of the clinical and cost effectiveness of rivaroxaban for the prevention of adverse outcomes in patients after the acute management of acute coronary syndrome (ACS). The School of Health and Related Research Technology Appraisal Group at the University of Sheffield was commissioned to act as the independent Evidence Review Group (ERG)...
May 2016: PharmacoEconomics
Lisa S Manning, Thompson G Robinson
Although blood pressure (BP) levels may rise in the weeks preceding intracerebral haemorrhage (ICH), in contrast to findings in the ischaemic stroke population, the initial post-ICH BP is often much higher than the last pre-morbid level. Elevated BP is therefore common in acute ICH, often with markedly elevated levels, and is associated with poor outcomes, though the exact pathophysiological mechanisms remain unclear. The Antihypertensive Treatment of Acute Cerebral Haemorrhage (ATACH) trial and the INTEnsive blood pressure Reduction in Acute Cerebral haemorrhage Trial (INTERACT) demonstrated that early and intensive lowering of elevated BP in the acute ICH period is feasible and safe...
2015: Frontiers of Neurology and Neuroscience
Polly Scutt, Dan Blackburn, Kailash Krishnan, Clive Ballard, Alistair Burns, Gary A Ford, Jonathan Mant, Peter Passmore, Stuart Pocock, John Reckless, Nikola Sprigg, Rob Stewart, Joanna M Wardlaw, Philip M Bath
BACKGROUND: A common complication after stroke is development of cognitive impairment and dementia. However, effective strategies for reducing the risk of developing these problems remain undefined. Potential strategies include intensive lowering of blood pressure (BP) and/or lipids. This paper summarises the baseline characteristics, statistical analysis plan and feasibility of a randomised control trial of blood pressure and lipid lowering in patients post-stroke with the primary objective of reducing cognitive impairment and dementia...
2015: Trials
Jacques Bouget, Emmanuel Oger
INTRODUCTION: To describe the population admitted in an emergency department of a teaching hospital for severe bleeding associated with direct oral anticoagulants (DOAC). METHOD: During a three-year period (2012-2014) patients older than 16 years were prospectively identified by haemorrhagic symptoms from computerised requests. At least one of the following criteria defined major haemorrhage: haemorrhagic shock, unstable haemodynamic, need for transfusion or haemostatic procedure, or a life threatening location...
December 2015: Thrombosis Research
Antonio Barquet, Andrés Gelink, Peter V Giannoudis
INTRODUCTION: Vascular injuries (VI) presenting during internal fixation (IF) of proximal femoral fractures (PFF) are potentially limb- and life-threatening. The purpose of this systematic review of the literature is to report on their incidence, associated complications and to give special emphasis in their prevention. MATERIALS AND METHODS: A comprehensive review of the literature was undertaken using the PRISMA guidelines with no language restriction. Case reports of VIPFF-IF and series of PFF-IF with cases of VI published between inception of journals to March 2015 were eligible for inclusion...
December 2015: Injury
Abby Keable, Kate Fenna, Ho Ming Yuen, David A Johnston, Neil R Smyth, Colin Smith, Rustam Al-Shahi Salman, Neshika Samarasekera, James A R Nicoll, Johannes Attems, Rajesh N Kalaria, Roy O Weller, Roxana O Carare
Deposition of amyloid β (Aβ) in the walls of cerebral arteries as cerebral amyloid angiopathy (CAA) suggests an age-related failure of perivascular drainage of soluble Aβ from the brain. As CAA is associated with Alzheimer's disease and with intracerebral haemorrhage, the present study determines the unique sequence of changes that occur as Aβ accumulates in artery walls. Paraffin sections of post-mortem human occipital cortex were immunostained for collagen IV, fibronectin, nidogen 2, Aβ and smooth muscle actin and the immunostaining was analysed using Image J and confocal microscopy...
May 2016: Biochimica et Biophysica Acta
Kypros H Nicolaides, Argyro Syngelaki, Liona C Poon, Catalina de Paco Matallana, Walter Plasencia, Francisca S Molina, Gemma Picciarelli, Natasa Tul, Ebru Celik, Tze Kin Lau, Roberto Conturso
BACKGROUND: Preterm birth is the leading cause of neonatal death and handicap in survivors. Although twins are found in 1.5% of pregnancies they account for about 25% of preterm births. Randomized controlled trials in singleton pregnancies reported that the prophylactic use of progestogens, cervical cerclage and cervical pessary reduce significantly the rate of early preterm birth. In twin pregnancies, progestogens and cervical cerclage have been shown to be ineffective in reducing preterm birth...
January 2016: American Journal of Obstetrics and Gynecology
Noel Aaron Peter, Hermant Pandit, Grace Le, Godfrey Muguti, Christopher Lavy
BACKGROUND: Africa has one of the highest road-traffic mortality rates in the world. Nurses and clinical officers play a pivotal part in trauma care as a result of substantial shortage of doctors. The COOL (COSECSA-Oxford-Orthopaedic-Link) programme has delivered primary trauma care (PTC) training in nine sub-Saharan African countries across a wide cadre of health-workers (540 doctors, 260 nurses, 119 clinical officers, and 111 medical students). This prospective study investigates the effect of 28 consecutive PTCs and the training challenges that exist between different cadres and health institutions...
April 27, 2015: Lancet
Lian-Chen Wang, Shih-Ming Jung, Kuang-Yao Chen, Tzu-Yi Wang, Chung-Han Li
Human cerebral angiostrongyliasis becomes an emerging disease in many parts of the world. By postmortem examination, Angiostrongylus cantonensis have been reported to cause severe pathological changes in the central nervous system. The present study was designed to determine the temporal-spatial pathological changes through experimental infections and histopathological examination of permissive (SD rats) and non-permissive (ICR mice) hosts. After infecting SD rats with 25, 50, or 100 third-stage larvae (L3) and ICR mice with 25 L3, one animal from each group was sacrificed daily from day 1 to day 30 post-infection...
October 2015: Experimental Parasitology
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