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https://www.readbyqxmd.com/read/28103486/combined-toxic-effects-and-mechanisms-of-microsystin-lr-and-copper-on-vallisneria-natans-lour-hara-seedlings
#1
Zhi Wang, Junqian Zhang, Enhua Li, Liang Zhang, Xuelei Wang, Lirong Song
Microcystin-LR (MCLR) and copper are commonly found in eutrophic water bodies because of eutrophic run-offs, cyanobacterial blooms, and copper algicide applications. However, the ecotoxicological risk of their combination remains unknown. This study investigated the effect of MCLR, Cu, and their mixture on the growth and physiological responses of Vallisneria natans. Results showed that the combined toxicity of them was concentration dependent. Synergistic effects were elicited at low concentrations of MCLR and Cu exposure (≤0...
January 3, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28103181/positive-schemas-psychopathology-and-quality-of-life-in-children-with-pediatric-cancer-a-pilot-study
#2
Brae Anne McArthur, Douglas Strother, Fiona Schulte
PURPOSE: Research in the area of pediatric oncology has shown that although some children and youth diagnosed with this disease cope adaptively after their diagnosis, others continue to have long-term psychosocial difficulties. The potential mechanisms that may protect against the experience of psychopathology and poor quality of life within this population are not well known. The purpose of this pilot study was to utilize a new comprehensive measure of positive schemas to better understand the relationship between positive schemas, quality of life, and psychopathology, for children on active treatment for cancer...
January 19, 2017: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/28098747/integrated-treatment-of-ptsd-and-substance-use-disorders-the-mediating-role-of-ptsd-improvement-in-the-reduction-of-depression
#3
Kristina J Korte, Kaitlin E Bountress, Rachel L Tomko, Therese Killeen, Megan Moran-Santa Maria, Sudie E Back
Posttraumatic stress disorder (PTSD) represents one of the most common mental health disorders, particularly among veterans, and is associated with significant distress and impairment. This highly debilitating disorder is further complicated by common comorbid psychiatric disorders, such as substance use disorders (SUD). Individuals with PTSD and co-occurring SUD also commonly present with secondary symptoms, such as elevated depression. Little is known, however, about how these secondary symptoms are related to treatment outcome...
January 13, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28097793/living-with-cardiac-resynchronization-therapy-challenges-for-people-with-heart-failure
#4
Shadi Dehghanzadeh, Nahid Dehghan Nayeri, Shokoh Varaei, Jalal Kheirkhah
The number of people with heart failure requiring implantation of a cardiac resynchronization device is increasing in Iran. Although this intervention is an effective life-saving treatment, several challenges are associated with patients' lifestyle after insertion. This study identified the challenges and coping mechanisms of Iranians with heart failure living with cardiac resynchronization therapy. A qualitative approach using conventional content analysis was adopted. Seventeen people with heart failure and three nurses were recruited between December 2014 and November 2015 from a teaching hospital and a private clinic in Rasht, Iran...
January 18, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/28087802/cytochrome-c-peroxidase-ccp-is-a-molecular-determinant-of-the-oxidative-stress-response-in-the-extreme-acidophilic-leptospirillum-sp-cf-1
#5
C Zapata, B Paillavil, R Chávez, P Álamos, G Levicán
Bioleaching processes are used to recover metals from sulfidic ores. Biofilm formation on ores is important for bioleaching because the attached microorganisms start the leaching process by concentrating ferric ions in the extracellular matrix. It has been shown that hydrogen peroxide is spontaneously generated on the surface of ores and that it negatively influences the growth and activity of microorganisms. However, the mechanism by which bioleaching microorganisms tolerate exogenous H2O2 as an adaptive trait remains elusive...
January 12, 2017: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/28087151/the-key-to-mn-homeostasis-in-plants-regulation-of-mn-transporters
#6
REVIEW
Ji Feng Shao, Naoki Yamaji, Ren Fang Shen, Jian Feng Ma
Plants only require small amounts of manganese (Mn) for healthy growth, but Mn concentrations in soil solution vary from sub-micromolar to hundreds of micromolar across the growth period. Therefore, plants must deal with large Mn concentration fluctuations, but the molecular mechanisms underlying how plants cope with low and high Mn concentrations are poorly understood. In this Opinion we discuss the role of Mn transporters in the uptake, distribution, and detoxification of Mn in response to changes in Mn concentrations through their regulation at the transcriptional and protein levels, mainly focusing on rice, an Mn-tolerant and -accumulating species...
January 10, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28080096/emotion-dysregulation-explains-associations-between-anxiety-sensitivity-and-hazardous-drinking-and-drinking-motives-among-adult-treatment-seeking-smokers
#7
Daniel J Paulus, Jaclyn Valadka, Michael S Businelle, Matthew W Gallagher, Andres G Viana, Norman B Schmidt, Michael J Zvolensky
Smoking and drinking frequently co-occur. For example, alcohol use is associated with smoking lapses during quit attempts. However, little is known regarding psychological factors explaining drinking among smokers. Anxiety sensitivity is a risk factor associated with hazardous drinking and drinking to cope and/or conform, although little is known about mechanisms underlying such associations. One potential explanatory factor is emotion dysregulation. The current study examined emotion dysregulation as an explanatory factor underlying Anxiety Sensitivity and 5 alcohol-related outcomes: hazardous drinking, alcohol consumption, alcohol problems, coping-oriented drinking, and drinking to conform...
January 12, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28075024/uncovering-iron-regulation-with-species-specific-transcriptome-patterns-in-atlantic-and-coho-salmon-during-a-caligus-rogercresseyi-infestation
#8
V Valenzuela-Muñoz, S Boltaña, C Gallardo-Escárate
Salmon species cultured in Chile evidence different levels of susceptibility to the sea louse Caligus rogercresseyi. These differences have mainly been associated with specific immune responses. Moreover, iron regulation seems to be an important mechanism to confer immunity during the host infestation. This response called nutritional immunity has been described in bacterial infections, despite that no comprehensive studies involving in marine ectoparasites infestation have been reported. With this aim, we analysed the transcriptome profiles of Atlantic and coho salmon infected with C...
January 11, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28071755/variation-in-short-term-and-long-term-responses-of-photosynthesis-and-isoprenoid-mediated-photoprotection-to-soil-water-availability-in-four-douglas-fir-provenances
#9
Laura Verena Junker, Anita Kleiber, Kirstin Jansen, Henning Wildhagen, Moritz Hess, Zachary Kayler, Bernd Kammerer, Jörg-Peter Schnitzler, Jürgen Kreuzwieser, Arthur Gessler, Ingo Ensminger
For long-lived forest tree species, the understanding of intraspecific variation among populations and their response to water availability can reveal their ability to cope with and adapt to climate change. Dissipation of excess excitation energy, mediated by photoprotective isoprenoids, is an important defense mechanism against drought and high light when photosynthesis is hampered. We used 50-year-old Douglas-fir trees of four provenances at two common garden experiments to characterize provenance-specific variation in photosynthesis and photoprotective mechanisms mediated by essential and non-essential isoprenoids in response to soil water availability and solar radiation...
January 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071586/milestones-in-crh-research
#10
George P Chrousos, Emmanouil Zoumakis
The Corticotropin-releasing Hormone (CRH) mammalian family members include CRH, urocortin I, Stresscopin (SCP) and Stresscopin-related peptide (SRP), along with the CRH receptors type 1 (CRHR1) and type 2 (CRHR2), and CRH-binding protein (CRH-BP). These family members differ in their tissue distribution and pharmacology. Several studies have provided evidence supporting an important role of this family in the regulation of the neuroendocrine and behavioral responses to stress. Regulation of the relative contribution of CRH and its homologs and the two CRH receptors in brain CRH pathways may be essential in coordinating physiologic responses to stress...
January 9, 2017: Current Molecular Pharmacology
https://www.readbyqxmd.com/read/28070283/spatial-and-temporal-avoidance-of-risk-within-a-large-carnivore-guild
#11
Egil Dröge, Scott Creel, Matthew S Becker, Jassiel M'soka
Within a large carnivore guild, subordinate competitors (African wild dog, Lycaon pictus, and cheetah, Acinonyx jubatus) might reduce the limiting effects of dominant competitors (lion, Panthera leo, and spotted hyena, Crocuta crocuta) by avoiding them in space, in time, or through patterns of prey selection. Understanding how these competitors cope with one other can inform strategies for their conservation. We tested how mechanisms of niche partitioning promote coexistence by quantifying patterns of prey selection and the use of space and time by all members of the large carnivore guild within Liuwa Plain National Park in western Zambia...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28070121/nrsf-dependent-epigenetic-mechanisms-contribute-to-programming-of-stress-sensitive-neurons-by-neonatal-experience-promoting-resilience
#12
A Singh-Taylor, J Molet, S Jiang, A Korosi, J L Bolton, Y Noam, K Simeone, J Cope, Y Chen, A Mortazavi, T Z Baram
Resilience to stress-related emotional disorders is governed in part by early-life experiences. Here we demonstrate experience-dependent re-programming of stress-sensitive hypothalamic neurons, which takes place through modification of neuronal gene expression via epigenetic mechanisms. Specifically, we found that augmented maternal care reduced glutamatergic synapses onto stress-sensitive hypothalamic neurons and repressed expression of the stress-responsive gene, Crh. In hypothalamus in vitro, reduced glutamatergic neurotransmission recapitulated the repressive effects of augmented maternal care on Crh, and this required recruitment of the transcriptional repressor repressor element-1 silencing transcription factor/neuron restrictive silencing factor (NRSF)...
January 10, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28069435/astrocytes-and-presynaptic-plasticity-in-the-striatum-evidence-and-unanswered-questions
#13
Anton Dvorzhak, Igor Melnick, Rosemarie Grantyn
One of the main functions of astrocytes is to ensure glutamate homeostasis by glutamate uptake and glutamine synthesis. However, during the past ten years it has become clear that astrocytes may also induce changes in synaptic glutamate release when respective pathways must cope with the consequences of brain damage or other alterations in their functional requirements. The loss of glutamatergic synapses in Parkinson's and Huntington's disease is likely to associate with a continuous redistribution of presynaptic activity within the pool of surviving synapses, and astrocytes may have a role in the maintenance of independent control at individual glutamate release sites...
January 6, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28068907/hospitalized-care-for-mdr-tb-in-port-harcourt-nigeria-a-qualitative-study
#14
Kingsley Lezor Bieh, Ralf Weigel, Helen Smith
BACKGROUND: In Nigeria multidrug-resistant tuberculosis (MDR-TB) is prevalent in 2.9% of new TB cases and 14% of retreatment cases, and the country is one of 27 with high disease burden globally. Patients are admitted and confined to one of ten MDR-TB treatment facilities throughout the initial 8 months of treatment. The perspectives of MDR-TB patients shared on social media and in academic research and those of providers are limited to experiences of home-based care. In this study we explored the views of hospitalised MDR-TB patients and providers in one treatment facility in Nigeria, and describe how their experiences are linked to accessibility of care and support services, in line with international goals...
January 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28063599/-risk-factors-and-psychological-vulnerabilities-to-binge-drinking-in-youth
#15
E De Wever, V Quaglino
For years, a large number of studies have demonstrated the harmful effects of alcohol consumption on the brain and therefore on behavior and cognition. These studies first aimed at identifying the consequences of alcohol abuse consumption, more specifically in pathologies such as alcohol-dependence or Korsakoff syndrome. Researchers then also started to focus on vulnerabilities to alcohol consumption, especially in hyper fast alcohol consumption called binge-drinking (BD). Indeed BD, which is a particularly dangerous form of alcohol consumption, is usually observed in adolescents and young adults...
January 4, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28062561/sperm-sensory-signaling
#16
Dagmar Wachten, Jan F Jikeli, U Benjamin Kaupp
Fertilization is exceptionally complex and, depending on the species, happens in entirely different environments. External fertilizers in aquatic habitats, like marine invertebrates or fish, release their gametes into the seawater or freshwater, whereas sperm from most internal fertilizers like mammals cross the female genital tract to make their way to the egg. Various chemical and physical cues guide sperm to the egg. Quite generally, these cues enable signaling pathways that ultimately evoke a cellular Ca(2+) response that modulates the waveform of the flagellar beat and, hence, the swimming path...
January 6, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/28058803/would-behavioral-thermoregulation-enables-pregnant-viviparous-tropical-lizards-to-cope-with-a-warmer-world
#17
Saúl López-Alcaide, Miguel Nakamura, Eric N Smith, Enrique Martínez-Meyer
Sceloporus lizards depend on external heat to achieve their preferred temperature (Tse1 ) for performing physiological processes. Evidence both in the field and laboratory indicates that pregnant females of this genus select body temperatures (Tb ) lower than 34°C as higher temperatures may be lethal to embryos. Therefore, thermoregulation is crucial for successful embryo development. Given the increase in global air temperature, it is expected that the first compensatory response of species that inhabit tropical climates will be behavioral thermoregulation...
January 5, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/28058723/contrasting-phenotypic-plasticity-in-the-photoprotective-strategies-of-the-invasive-species-carpobrotus-edulis-and-the-coexisting-native-species-crithmum-maritimum
#18
Erola Fenollosa, Sergi Munné-Bosch, Marta Pintó-Marijuan
Photoprotective strategies vary greatly within the plant kingdom and reflect a plant's physiological status and capacity to cope with environment variations. The plasticity and intensity of these responses may determine plant success. Invasive species are reported to show increased vigor to displace native species. Describing the mechanisms that confer such vigor is essential to understanding the success of invasive species. We performed an experiment whereby two species were monitored: Carpobrotus edulis, an aggressive invasive species in the Mediterranean basin, and Crithmum maritimum, a coexisting native species in the Cap de Creus Natural Park (NE Spain)...
January 5, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28054417/aboriginal-prisoners-and-cognitive-impairment-the-impact-of-dual-disadvantage-on-social-and-emotional-wellbeing
#19
S M Shepherd, J R P Ogloff, D Shea, J E Pfeifer, Y Paradies
BACKGROUND: Negligible information is available regarding the Social and Emotional Wellbeing (SEWB) needs of Aboriginal Australian individuals in custody with cognitive impairment. This is problematic given that Aboriginal people with cognitive impairment often experience dual disadvantage in the context of the justice system. This study sought to ascertain the relationship between cognitive impairment and mental health/cultural needs (SEWB) Aboriginal and Torres Strait Islander people in custody...
January 5, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28052711/-like-the-worst-toothache-you-ve-had-how-people-with-rheumatoid-arthritis-describe-and-manage-pain
#20
Maria Bergström, Inger Ahlstrand, Ingrid Thyberg, Torbjörn Falkmer, Björn Börsbo, Mathilda Björk
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease often associated with disability. Despite new treatments, pain and activity limitations are still present. OBJECTIVES: To describe how persons with RA experience and manage pain in their daily life. METHODS: Seven semi-structured focus groups (FGs) were conducted and analyzed using content analysis. RESULTS: The analysis revealed four categories: 1) Pain expresses itself in different ways referred to pain as overwhelming, aching or as a feeling of stiffness...
January 5, 2017: Scandinavian Journal of Occupational Therapy
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