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https://www.readbyqxmd.com/read/27932965/the-neural-correlates-of-humor-creativity
#1
Ori Amir, Irving Biederman
Unlike passive humor appreciation, the neural correlates of real-time humor creation have been unexplored. As a case study for creativity, humor generation uniquely affords a reliable assessment of a creative product's quality with a clear and relatively rapid beginning and end, rendering it amenable to neuroimaging that has the potential for reflecting individual differences in expertise. Professional and amateur "improv" comedians and controls viewed New Yorker cartoon drawings while being scanned. For each drawing, they were instructed to generate either a humorous or a mundane caption...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27931915/stratifying-empiric-risk-of-schizophrenia-among-first-degree-relatives-using-multiple-predictors-in-two-independent-indian-samples
#2
Triptish Bhatia, Elizabeth A Gettig, Irving I Gottesman, Jonathan Berliner, N N Mishra, Vishwajit L Nimgaonkar, Smita N Deshpande
BACKGROUND: Schizophrenia (SZ) has an estimated heritability of 64-88%, with the higher values based on twin studies. Conventionally, family history of psychosis is the best individual-level predictor of risk, but reliable risk estimates are unavailable for Indian populations. Genetic, environmental, and epigenetic factors are equally important and should be considered when predicting risk in 'at risk' individuals. OBJECTIVE: To estimate risk based on an Indian schizophrenia participant's family history combined with selected demographic factors...
December 2016: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/27931123/developments-in-multibreath-washout-testing-in-children-with-cystic-fibrosis
#3
Clare Saunders, Katie Bayfield, Samantha Irving, Christopher Short, Andrew Bush, Jane C Davies
Lung Clearance Index (LCI) is becoming recognized as an important addition in the monitoring of pediatric cystic fibrosis (CF). The non-invasive technique is easy to perform in all ages, reproducible and increasingly being used in clinical trials. There is interest to utilize it within the clinic setting but its current use is mostly as a research tool. The procedure is highly dependent on skilled operators and a relaxed testing environment is key to obtaining good quality measurements. Standardization of LCI is part of an ongoing collaborative, multicenter process...
December 9, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27923460/comparison-of-characteristics-and-complications-in-men-versus-women-undergoing-chronic-total-occlusion-percutaneous-intervention
#4
Vinoda Sharma, William Wilson, William Smith, Margaret McEntegart, Keith Oldroyd, Novalia Sidik, Alan Bagnall, Mohaned Egred, John Irving, Julian Strange, Thomas Johnson, Simon Walsh, Colm Hanratty, James Spratt
Gender differences exist in clinical outcomes after routine percutaneous coronary intervention (PCI), but studies reporting such outcomes after chronic total occlusion (CTO) PCI are limited. We assessed the characteristics and outcomes of female patients undergoing CTO PCI. We retrospectively analyzed a dedicated national (United Kingdom) prospective CTO database from 2011 to 2015 for outcomes and characteristics of female patients undergoing CTO PCI (unmatched and propensity matched). Female patients constituted 20...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27914345/biopolymer-matrix-for-nano-encapsulation-of-urease-a-model-protein-and-its-application-in-urea-detection
#5
Abhishek Saxena, Arpita Bhattacharya, Satish Kumar, Irving R Epstein, Rachana Sahney
Alginate microparticles and nanoparticles crosslinked with Ca(+2) ions are frequently employed in biomedical applications. Here we use microemulsion polymerization to prepare alginate nanoparticles (nanogels) using different crosslinking ions (Ca(+2), Sr(+2), Ba(+2)) to encapsulate a model protein, urease enzyme (jackbeans). With alginate concentrations of 0.2wt% in the aqueous phase, emulsion droplets showed good stability and narrow, monomodal distributions with radii ∼65±10nm. The size of the nanogel varies with the crosslinking cation and its affinity for the mannuronate and guluronate units in the linear alginate chain...
November 9, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27908786/distinct-requirements-of-wls-wnt9a-wnt5b-and-gpc4-in-regulating-chondrocyte-maturation-and-timing-of-endochondral-ossification
#6
Irving Tc Ling, Lucie Rochard, Eric C Liao
Formation of the mandible requires progressive morphologic change, proliferation, differentiation and organization of chondrocytes preceding osteogenesis. The Wnt signaling pathway is involved in regulating bone development and maintenance. Chondrocytes that are fated to become bone require Wnt to polarize and orientate appropriately to initiate the endochondral ossification program. Although the canonical Wnt signaling has been well studied in the context of bone development, the effects of non-canonical Wnt signaling in regulating the timing of cartilage maturation and subsequent bone formation in shaping ventral craniofacial structure is not fully understood...
November 29, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27905678/a-phase-i-ii-trial-of-at9283-a-selective-inhibitor-of-aurora-kinase-in-children-with-relapsed-or-refractory-acute-leukemia-challenges-to-run-early-phase-clinical-trials-for-children-with-leukemia
#7
B Vormoor, G J Veal, M J Griffin, A V Boddy, J Irving, L Minto, M Case, U Banerji, K E Swales, J R Tall, A S Moore, M Toguchi, G Acton, K Dyer, C Schwab, C J Harrison, J D Grainger, D Lancaster, P Kearns, D Hargrave, J Vormoor
Aurora kinases regulate mitosis and are commonly overexpressed in leukemia. This phase I/IIa study of AT9283, a multikinase inhibitor, was designed to identify maximal tolerated doses, safety, pharmacokinetics, and pharmacodynamic activity in children with relapsed/refractory acute leukemia. The trial suffered from poor recruitment and terminated early, therefore failing to identify its primary endpoints. AT9283 caused tolerable toxicity, but failed to show clinical responses. Future trials should be based on robust preclinical data that provide an indication of which patients may benefit from the experimental agent, and recruitment should be improved through international collaborations and early combination with established treatment strategies...
December 1, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27904541/effect-of-eight-week-aerobic-resistive-and-interval-exercise-routines-on-respiratory-parameters-in-non-athlete-women
#8
Vahan Moradians, Alireza Rahimi, Seyed Ali Javad Moosavi, Fateme Sadat Sahebkar Khorasani, Ali Mazaherinejad, Masoud Mortezazade, Hanieh Raji
BACKGROUND: There are not many studies about the effects of physical activity on pulmonary function in normal population. However, it seems that strengthening and persevering respiratory muscles is an effective technique for improving pulmonary function. OBJECTIVE: The purpose of this study was to evaluate and compare the effects of eight-week aerobic, resistance, and interval exercise routines on respiratory parameters in non-athlete women. MATERIALS AND METHODS: Thirty-six non-athlete women between 18-25 years old participated in this prospective quasi-experimental trial...
2016: Tanaffos
https://www.readbyqxmd.com/read/27901550/ultrafast-optical-property-map-generation-using-lookup-tables
#9
Joseph Angelo, Christina R Vargas, Bernard T Lee, Irving J Bigio, Sylvain Gioux
No abstract text is available yet for this article.
November 1, 2016: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/27900598/oxidative-stress-mediated-hippocampal-neuron-apoptosis-participated-in-carbon-disulfide-induced-rats-cognitive-dysfunction
#10
Shuo Wang, Gleniece Irving, Lulu Jiang, Hui Wang, Ming Li, Xujing Wang, Wenting Han, Yongpeng Xu, Yilin Yang, Tao Zeng, Fuyong Song, Xiulan Zhao, Keqin Xie
Occupational exposure to carbon disulfide (CS2) exhibits central nervous systems toxicity. But the mechanism is unclear. The present study was designed to investigate the relationship between the CNS damage and cognitive dysfunction caused by CS2, and eventually reveal the possible oxidative-related mechanism of hippocampus pathological changes in CS2 exposed rats. Male Wistar rats were administrated with CS2 at dosage of 200, 400 and 600 mg/kg for consecutive 20 days, respectively. Cognitive performances were evaluated by Morris water maze tests...
November 29, 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27883085/phenotypic-and-functional-characterization-of-the-major-lymphocyte-populations-in-the-fruit-eating-bat-pteropus-alecto
#11
Julia María Martínez Gómez, Pravin Periasamy, Charles-Antoine Dutertre, Aaron Trent Irving, Justin Han Jia Ng, Gary Crameri, Michelle L Baker, Florent Ginhoux, Lin-Fa Wang, Sylvie Alonso
The unique ability of bats to act as reservoir for viruses that are highly pathogenic to humans suggests unique properties and functional characteristics of their immune system. However, the lack of bat specific reagents, in particular antibodies, has limited our knowledge of bat's immunity. Using cross-reactive antibodies, we report the phenotypic and functional characterization of T cell subsets, B and NK cells in the fruit-eating bat Pteropus alecto. Our findings indicate the predominance of CD8(+) T cells in the spleen from wild-caught bats that may reflect either the presence of viruses in this organ or predominance of this cell subset at steady state...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882501/a-review-of-a-gp-registrar-run-mobile-health-clinic-for-homeless-people
#12
A O'Carroll, N Irving, J O'Neill, E Flanagan
BACKGROUND: Homeless people have excessively high morbidity and mortality rates, yet they face barriers accessing primary care. A mobile health clinic, staffed by GP registrars, was developed to provide services to homeless people, particularly rough sleepers and sex workers. AIM: The aims were to improve access to primary care and to challenge the stereotypes and prejudices of GP registrars through direct contact with homeless people. DESIGN AND SETTING: This was a qualitative study; questionnaires were completed on the mobile health clinic and two focus groups were conducted...
November 24, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27880904/lyve1-marks-the-divergence-of-yolk-sac-definitive-hemogenic-endothelium-from-the-primitive-erythroid-lineage
#13
Lydia K Lee, Yasamine Ghorbanian, Wenyuan Wang, Yanling Wang, Yeon Joo Kim, Irving L Weissman, Matthew A Inlay, Hanna K A Mikkola
The contribution of the different waves and sites of developmental hematopoiesis to fetal and adult blood production remains unclear. Here, we identify lymphatic vessel endothelial hyaluronan receptor-1 (LYVE1) as a marker of yolk sac (YS) endothelium and definitive hematopoietic stem and progenitor cells (HSPCs). Endothelium in mid-gestation YS and vitelline vessels, but not the dorsal aorta and placenta, were labeled by Lyve1-Cre. Most YS HSPCs and erythro-myeloid progenitors were Lyve1-Cre lineage traced, but primitive erythroid cells were not, suggesting that they represent distinct lineages...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27879405/does-citrulline-sit-at-the-nexus-of-metformin-s-pleotropic-effects-on-metabolism-and-mediate-its-salutatory-effects-in-individuals-with-type-2-diabetes
#14
Brian A Irving, Guillaume Spielmann
No abstract text is available yet for this article.
December 2016: Diabetes
https://www.readbyqxmd.com/read/27876039/evidence-of-a-multiple-insecticide-resistance-in-the-malaria-vector-anopheles-funestus-in-south-west-nigeria
#15
Rousseau J Djouaka, Seun M Atoyebi, Genevieve M Tchigossou, Jacob M Riveron, Helen Irving, Romaric Akoton, Michael O Kusimo, Adekunle A Bakare, Charles S Wondji
BACKGROUND: Knowing the extent and spread of insecticide resistance in malaria vectors is vital to successfully manage insecticide resistance in Africa. This information in the main malaria vector, Anopheles funestus sensu stricto, is completely lacking in the most populous country in Africa, Nigeria. This study reports the insecticide susceptibility status and the molecular basis of resistance of An. funestus as well as its involvement in malaria transmission in Akaka-Remo, a farm settlement village in southwest Nigeria...
November 22, 2016: Malaria Journal
https://www.readbyqxmd.com/read/27875363/pmtct-option-b-does-not-increase-preterm-birth-risk-and-may-prevent-extreme-prematurity-a-retrospective-cohort-study-in-malawi
#16
Maganizo B Chagomerana, William C Miller, Brian W Pence, Mina C Hosseinipour, Irving F Hoffman, Robert J Flick, Hannock Tweya, Soyapi Mumba, Frank Chibwandira, Kimberly A Powers
OBJECTIVE: To estimate preterm birth risk among infants of HIV-infected women in Lilongwe, Malawi according to maternal antiretroviral therapy (ART) status and initiation time under Option B+. DESIGN: Retrospective cohort study of HIV-infected women delivering at ≥27 weeks of gestation, April 2012-November 2015. Among women on ART at delivery, we restricted our analysis to those who initiated ART before 27 weeks of gestation. METHODS: We defined preterm birth as a singleton live birth at ≥27 and <37 weeks of gestation, with births at <32 weeks classified as extremely to very preterm...
November 21, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27875309/rna-sequencing-reveals-a-role-of-tonebp-in-regulation-of-pro-inflammatory-genes-in-response-to-hyperosmolarity-in-healthy-nucleus-pulposus-cells-a-homeostatic-response
#17
Zariel I Johnson, Irving M Shapiro, Makarand V Risbud
Transcription factor Tonicity-Responsive Enhancer-Binding Protein (TonEBP/NFAT5) is critical for osmo-adaptation and extracellular matrix homeostasis of nucleus pulposus (NP) cells in their hypertonic tissue niche. Recent studies implicate TonEBP signaling in inflammatory disease and rheumatoid arthritis pathogenesis. However, broader functions of TonEBP in the disc remain unknown. RNA-sequencing was performed on NP cells with TonEBP knockdown under hypertonic conditions. 1140 TonEBP-dependent genes were identified and categorized using Ingenuity Pathway Analysis...
November 8, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27872267/endophenotypes-epigenetics-polygenicity-and-more-irv-gottesman-s-dynamic-legacy
#18
David L Braff, Carol A Tamminga
First, we describe the hallmark contributions of Irv Gottesman's pioneering scholarship for schizophrenia research including concepts of polygenicity, gene × environment interactions, epigenetics and the endophenotype concept. Gottesman and colleagues' twin studies showed that genes, not social factors, mediate schizophrenia risk. He then showed that schizophrenia is highly polygenic. Next, he introduced the concept of epigenetics into schizophrenia research. Gottesman then introduced the quantitative endophenotype concept...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27869480/caregiver-profiles-in-dementia-related-to-quality-of-life-depression-and-perseverance-time-in-the-european-actifcare-study-the-importance-of-social-health
#19
Eveline P C J Janssen, Marjolein de Vugt, Sebastian Köhler, Claire Wolfs, Liselot Kerpershoek, Ron L H Handels, Martin Orrell, Bob Woods, Hannah Jelley, Astrid Stephan, Anja Bieber, Gabriele Meyer, Knut Engedal, Geir Selbaek, Anders Wimo, Kate Irving, Louise Hopper, Maria Marques, Manuel Gonçalves-Pereira, Elisa Portolani, Orazio Zanetti, Frans R Verhey
OBJECTIVES: To identify caregiver profiles of persons with mild to moderate dementia and to investigate differences between identified caregiver profiles, using baseline data of the international prospective cohort study Actifcare. METHODS: A latent class analysis was used to discover different caregiver profiles based on disease related characteristics of 453 persons with dementia and their 453 informal caregivers. These profiles were compared with regard to quality of life (CarerQoL score), depressive symptoms (HADS-D score) and perseverance time...
November 21, 2016: Aging & Mental Health
https://www.readbyqxmd.com/read/27867654/patient-prosthesis-mismatch-surgical-aortic-valve-replacement-versus-transcatheter-aortic-valve-replacement-in-high-risk-patients-with-aortic-stenosis
#20
COMMENT
Ravi K Ghanta, Irving L Kron
Patient prosthesis mismatch (PPM) can occur when a prosthetic aortic valve has an effective orifice area (EOA) less than that of a native valve. A recent study by Zorn and colleagues evaluated the incidence and significance of PPM in high risk patients with severe aortic stenosis who were randomized to transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR). TAVR is associated with decreased incidence of severe PPM compared to traditional SAVR valves. Severe PPM increases risk for death at 1 year postoperatively in high risk patients...
October 2016: Journal of Thoracic Disease
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