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https://www.readbyqxmd.com/read/29239130/establishing-the-cascade-of-care-for-hepatitis-c-in-england-benchmarking-to-monitor-impact-of-direct-acting-antivirals
#1
Ruth Simmons, Georgina Ireland, Will Irving, Matthew Hickman, Caroline Sabin, Samreen Ijaz, Mary Ramsay, Sam Lattimore, Sema Mandal
Little is known about engagement and retention in care of people diagnosed with chronic hepatitis C (HCV) in England. Establishing a cascade of care informs targeted interventions for improving case-finding, referral, treatment uptake and retention in care. Using data from the Sentinel Surveillance of Blood Borne Virus testing (SSBBV) between 2005-2014 we investigate the continuum of care of those tested for HCV in England. Persons ≥1 years old, with an anti-HCV test and subsequent RNA tests between 2005-2014 reported to SSBBV were collated...
December 14, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29235461/oxytocin-enhances-observational-fear-in-mice
#2
Marc T Pisansky, Leah R Hanson, Irving I Gottesman, Jonathan C Gewirtz
Empathy is fundamental to human relations, but its neural substrates remain largely unknown. Here we characterize the involvement of oxytocin in the capacity of mice to display emotional state-matching, an empathy-like behavior. When exposed to a familiar conspecific demonstrator in distress, an observer mouse becomes fearful, as indicated by a tendency to freeze and subsequent efforts to escape. Both intranasal oxytocin administration and chemogenetic stimulation of oxytocin neurons render males sensitive to the distress of an unfamiliar mouse...
December 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29233329/bedside-to-bench-and-back-again-surgeon-initiated-translational-research
#3
EDITORIAL
Eric J Charles, Irving L Kron
No abstract text is available yet for this article.
January 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29226531/pre-implant-left-ventricular-apex-position-predicts-risk-of-heartmate-ii-pump-thrombosis
#4
Leora T Yarboro, James Hunter Mehaffey, Robert B Hawkins, Irving L Kron, Gorav Ailawadi, John A Kern, Ravi K Ghanta
BACKGROUND: Thrombosis within a left ventricular assist device (LVAD) is a devastating complication that often necessitates device exchange. Few studies have evaluated the relationship between patient anatomy and pump thrombosis. We hypothesize that lateral displacement of the left ventricular (LV) apex increases risk for pump thrombosis. METHODS: All patients who underwent primary implantation of a HeartMate II (HM2) device (Thoratec, Pleasanton, CA) at a single center (2009-2015) were evaluated...
December 10, 2017: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29224257/models-of-care-for-non-invasive-ventilation-in-the-acute-copd-comparison-of-three-tertiary-hospitals-act3-study
#5
Kerry Parker, Vara Perikala, Ali Aminazad, Zheng Deng, Brigitte Borg, Catherine Buchan, Jo Toghill, Louis B Irving, Jeremy Goldin, David Charlesworth, Ajay Mahal, Suhith Illesinghe, Matthew T Naughton, Alan Young
BACKGROUND AND OBJECTIVE: Non-invasive ventilation (NIV) improves clinical outcomes in hypercapnic acute exacerbations of COPD (AECOPD), but the optimal model of care remains unknown. METHODS: We conducted a prospective observational non-inferiority study comparing three models of NIV care: general ward (Ward) (1:4 nurse to patient ratio, thrice weekly consultant ward round), a high dependency unit (HDU) (1:2 ratio, twice daily ward round) and an intensive care unit (ICU) (1:1 ratio, twice daily ward round) model in three similar teaching tertiary hospitals...
December 10, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29216836/key-stakeholders-experiences-of-respite-services-for-people-with-dementia-and-their-perspectives-on-respite-service-development-a-qualitative-systematic-review
#6
Emma O' Shea, Suzanne Timmons, Eamon O' Shea, Siobhan Fox, Kate Irving
BACKGROUND: Respite services provide a break in the caregiving relationship for people with dementia and their carers, however they are often under-used and service acceptability can be low. This study aims to understand key stakeholders' experiences of respite services for people with dementia, with a view to informing respite service development. METHODS: A systematic search was conducted of the Pubmed/MedLine, Embase, Cinahl, PsychInfo, Scopus, Web of Science, and Cochrane databases (1980-2016, English) with fixed search terms relating to 'respite' and 'dementia', following PRISMA guidelines...
December 7, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29203681/patients-views-on-interactions-with-practitioners-for-type-2-diabetes-a-longitudinal-qualitative-study-in-primary-care-over-10-years
#7
Hajira Dambha-Miller, Barbora Silarova, Greg Irving, Ann Louise Kinmonth, Simon J Griffin
BACKGROUND: It has been suggested that interactions between patients and practitioners in primary care have the potential to delay progression of complications in type 2 diabetes. However, as primary care faces greater pressures, patient experiences of patient-practitioner interactions might be changing. AIM: To explore the views of patients with type 2 diabetes on factors that are of significance to them in patient-practitioner interactions in primary care after diagnosis, and over the last 10 years of living with the disease...
December 4, 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29202893/the-role-of-the-early-social-environment-on-epstein-barr-virus-infection-a-prospective-observational-design-using-the-millennium-cohort-study
#8
V Gares, L Panico, R Castagne, C Delpierre, M Kelly-Irving
Epstein-Barr virus (EBV) is a highly prevalent herpesvirus linked to infectious mononucleosis and several malignancies. This paper aims to study the association between children's early life social environment at 9 months and EBV infection at 3 years of age. METHODS: We used data on children included in the UK Millennium Cohort Study. We described the social environment using area-level and material factors as well as socioeconomic position (SEP) at 9 months. EBV was measured at 3 years of age (n = 12 457)...
December 5, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29200864/efficacy-of-noninvasive-cardiac-imaging-tests-in-diagnosis-and-management-of-stable-coronary-artery-disease
#9
REVIEW
Ify R Mordi, Athar A Badar, R John Irving, Jonathan R Weir-McCall, J Graeme Houston, Chim C Lang
The aim of this review was to discuss the current literature regarding the utility of noninvasive imaging in diagnosis and management of stable coronary artery disease (CAD) including recent data from large randomized trials assessing diagnosis and prognosis. Current guidelines recommend revascularization in patients with refractory angina and in those with potential prognostic benefit. Appropriate risk stratification through noninvasive assessment is important in ensuring patients are not exposed to unnecessary invasive coronary angiograms...
2017: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29183919/managing-alcohol-related-attendances-in-emergency-care-can-diversion-to-bespoke-services-lessen-the-burden
#10
EDITORIAL
Andy Irving, Steve Goodacre, Joanne Blake, Davina Allen, Simon C Moore
Acute alcohol intoxication (AAI) has a long history of burdening emergency care services. Healthcare systems around the world have explored a variety of different services that divert AAI away from EDs to better manage their condition. Little formal evaluation has been undertaken, particularly in the UK where alcohol misuse is one of the highest in the world. In this article, we outline a brief history of diversionary services, introduce the concept of Alcohol Intoxication Management Services (AIMS) and describe examples of AIMS in the UK...
November 28, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29180808/engagement-of-mhc-class-i-by-the-inhibitory-receptor-lilrb1-suppresses-macrophages-and-is-a-target-of-cancer-immunotherapy
#11
Amira A Barkal, Kipp Weiskopf, Kevin S Kao, Sydney R Gordon, Benyamin Rosental, Ying Y Yiu, Benson M George, Maxim Markovic, Nan G Ring, Jonathan M Tsai, Kelly M McKenna, Po Yi Ho, Robin Z Cheng, James Y Chen, Layla J Barkal, Aaron M Ring, Irving L Weissman, Roy L Maute
Exciting progress in the field of cancer immunotherapy has renewed the urgency of the need for basic studies of immunoregulation in both adaptive cell lineages and innate cell lineages. Here we found a central role for major histocompatibility complex (MHC) class I in controlling the phagocytic function of macrophages. Our results demonstrated that expression of the common MHC class I component β2-microglobulin (β2M) by cancer cells directly protected them from phagocytosis. We further showed that this protection was mediated by the inhibitory receptor LILRB1, whose expression was upregulated on the surface of macrophages, including tumor-associated macrophages...
November 27, 2017: Nature Immunology
https://www.readbyqxmd.com/read/29174394/visual-and-binocular-status-in-elementary-school-children-with-a-reading-problem
#12
Lisa W Christian, Krithika Nandakumar, Patricia K Hrynchak, Elizabeth L Irving
PURPOSE: This descriptive study provides a summary of the binocular anomalies seen in elementary school children identified with reading problems. METHODS: A retrospective chart review of all children identified with reading problems and seen by the University of Waterloo, Optometry Clinic, from September 2012 to June 2013. RESULTS: Files of 121 children (mean age 8.6 years, range 6-14 years) were reviewed. No significant refractive error was found in 81% of children...
November 21, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/29171661/a-randomised-controlled-trial-comparing-high-flow-nasal-oxygen-with-standard-management-for-conscious-sedation-during-bronchoscopy
#13
N Douglas, I Ng, F Nazeem, K Lee, P Mezzavia, R Krieser, D Steinfort, L Irving, R Segal
Traditional conscious sedation for endobronchial ultrasound procedures places patients at risk of desaturation, and high-flow nasal oxygen may reduce the risk. We designed a parallel-group randomised controlled trial of high-flow nasal oxygen at a flow rate of 30-70 l.min(-1) via nasal cannulae, compared with standard oxygen therapy at 10 l.min(-1) via a bite block in adults planned for conscious sedation for endobronchial ultrasound. The primary outcome was the proportion of patients experiencing desaturation (defined as SpO2 < 90%)...
November 24, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29170251/clustered-f8-missense-mutations-cause-hemophilia-a-by-combined-alteration-of-splicing-and-protein-biosynthesis-activity
#14
Irving Donadon, John H McVey, Isabella Garagiola, Alessio Branchini, Mimosa Mortarino, Flora Peyvandi, Francesco Bernardi, Mirko Pinotti
Dissection of pleiotropic effects of missense mutations, scarcely investigated in inherited diseases, is fundamental to understanding genotype-phenotype relationships. Missense mutations might impair mRNA processing in addition to protein properties. As a model for haemophilia A (HA) we investigated the highly prevalent F8 p.R2016W/c.6046c>t (exon 19) mutation. In expression studies exploiting lentiviral vectors, we demonstrated that the aminoacid change impairs both secretion (FVIII:Ag 11.0+/-0.4% of wild-type) and activity (FVIII:C 6...
November 23, 2017: Haematologica
https://www.readbyqxmd.com/read/29170247/origins-of-north-american-arid-land-verbenaceae-more-than-one-way-to-skin-a-cat
#15
Laura A Frost, Sarah McAdams Tyson, Patricia Lu-Irving, Nataly O'Leary, Richard G Olmstead
PREMISE OF THE STUDY: Verbenaceae originated and initially diversified in South America in wet forest habitats. They have diversified extensively in arid habitats in both South and North America. This study aims to understand the origin of the North American arid-land members of Verbenaceae. METHODS: A phylogenetic approach is used to examine four genera (Aloysia, Citharexylum, Glandularia, Verbena) in three distinct clades with representatives in North American deserts and disjunct South and North American distributions...
November 23, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/29168897/early-socioeconomic-conditions-and-severe-tooth-loss-in-middle-aged-costa-ricans
#16
Romain Fantin, Cyrille Delpierre, Michelle Kelly-Irving, Cristina Barboza Solís
OBJECTIVE: A wide literature shows a strong social gradient in tooth loss according to income, education and occupation, in both developed and developing countries. It has been shown associations between tooth loss and parental education and occupation, independently of adult conditions. To explore the role of early socioeconomic circumstances on tooth loss, we used a lifecourse model. We analysed the direct and indirect links between early socioeconomic conditions and severe adult tooth loss...
November 23, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29166080/continuum-balances-from-extended-hamiltonian-dynamics
#17
Giulio G Giusteri, Paolo Podio-Guidugli, Eliot Fried
The classical procedure devised by Irving and Kirkwood in 1950 and completed slightly later by Noll produces counterparts of the basic balance laws of standard continuum mechanics starting from an ordinary Hamiltonian description of the dynamics of a system of material points. Post-1980 molecular dynamics simulations of the time evolution of such systems use extended Hamiltonians such as those introduced by Andersen, Nosé, and Parrinello and Rahman. The additional terms present in these extensions affect the statistical properties of the system so as to capture certain target phenomenologies that would otherwise be beyond reach...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29166053/towards-the-irving-kirkwood-limit-of-the-mechanical-stress-tensor
#18
E R Smith, D M Heyes, D Dini
The probability density functions (PDFs) of the local measure of pressure as a function of the sampling volume are computed for a model Lennard-Jones (LJ) fluid using the Method of Planes (MOP) and Volume Averaging (VA) techniques. This builds on the study of Heyes, Dini, and Smith [J. Chem. Phys. 145, 104504 (2016)] which only considered the VA method for larger subvolumes. The focus here is typically on much smaller subvolumes than considered previously, which tend to the Irving-Kirkwood limit where the pressure tensor is defined at a point...
June 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29158380/anti-sirp%C3%AE-antibody-immunotherapy-enhances-neutrophil-and-macrophage-antitumor-activity
#19
Nan Guo Ring, Dietmar Herndler-Brandstetter, Kipp Weiskopf, Liang Shan, Jens-Peter Volkmer, Benson M George, Melanie Lietzenmayer, Kelly M McKenna, Tejaswitha J Naik, Aaron McCarty, Yunjiang Zheng, Aaron M Ring, Richard A Flavell, Irving L Weissman
Cancer immunotherapy has emerged as a promising therapeutic intervention. However, complete and durable responses are only seen in a fraction of patients who have cancer. A key factor that limits therapeutic success is the infiltration of tumors by cells of the myeloid lineage. The inhibitory receptor signal regulatory protein-α (SIRPα) is a myeloid-specific immune checkpoint that engages the "don't eat me" signal CD47 expressed on tumors and normal tissues. We therefore developed the monoclonal antibody KWAR23, which binds human SIRPα with high affinity and disrupts its binding to CD47...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29158301/author-response-dementia-risk-in-renal-dysfunction-a-systematic-review-and-meta-analysis-of-prospective-studies
#20
Kay Deckers, Ileana Camerino, Martin P J van Boxtel, Frans R J Verhey, Kate Irving, Carol Brayne, Miia Kivipelto, John M Starr, Kristine Yaffe, Peter W de Leeuw, Sebastian Köhler
No abstract text is available yet for this article.
November 21, 2017: Neurology
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