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https://www.readbyqxmd.com/read/29652246/metformin-in-non-diabetic-hyperglycaemia-the-glint-feasibility-rct
#1
Simon J Griffin, M Angelyn Bethel, Rury R Holman, Kamlesh Khunti, Nicholas Wareham, Gwen Brierley, Melanie Davies, Andrew Dymond, Rose Eichenberger, Philip Evans, Alastair Gray, Colin Greaves, Kyla Harrington, Graham Hitman, Greg Irving, Sarah Lessels, Ann Millward, John R Petrie, Martin Rutter, Mike Sampson, Naveed Sattar, Stephen Sharp
BACKGROUND: The treatment of people with diabetes with metformin can reduce cardiovascular disease (CVD) and may reduce the risk of cancer. However, it is unknown whether or not metformin can reduce the risk of these outcomes in people with elevated blood glucose levels below the threshold for diabetes [i.e. non-diabetic hyperglycaemia (NDH)]. OBJECTIVE: To assess the feasibility of the Glucose Lowering In Non-diabetic hyperglycaemia Trial (GLINT) and to estimate the key parameters to inform the design of the full trial...
April 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29643865/moonlighting-proteins-and-their-role-in-the-control-of-signaling-microenvironments-as-exemplified-by-cgmp-and-phytosulfokine-receptor-1-pskr1
#2
Helen R Irving, David M Cahill, Chris Gehring
Signal generating and processing complexes and changes in concentrations of messenger molecules such as calcium ions and cyclic nucleotides develop gradients that have critical roles in relaying messages within cells. Cytoplasmic contents are densely packed, and in plant cells this is compounded by the restricted cytoplasmic space. To function in such crowded spaces, scaffold proteins have evolved to keep key enzymes in the correct place to ensure ordered spatial and temporal and stimulus-specific message generation...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29643207/synchronous-diversification-of-sulawesi-s-iconic-artiodactyls-driven-by-recent-geological-events
#3
Laurent A F Frantz, Anna Rudzinski, Abang Mansyursyah Surya Nugraha, Allowen Evin, James Burton, Ardern Hulme-Beaman, Anna Linderholm, Ross Barnett, Rodrigo Vega, Evan K Irving-Pease, James Haile, Richard Allen, Kristin Leus, Jill Shephard, Mia Hillyer, Sarah Gillemot, Jeroen van den Hurk, Sharron Ogle, Cristina Atofanei, Mark G Thomas, Friederike Johansson, Abdul Haris Mustari, John Williams, Kusdiantoro Mohamad, Chandramaya Siska Damayanti, Ita Djuwita Wiryadi, Dagmar Obbles, Stephano Mona, Hally Day, Muhammad Yasin, Stefan Meker, Jimmy A McGuire, Ben J Evans, Thomas von Rintelen, Simon Y W Ho, Jeremy B Searle, Andrew C Kitchener, Alastair A Macdonald, Darren J Shaw, Robert Hall, Peter Galbusera, Greger Larson
The high degree of endemism on Sulawesi has previously been suggested to have vicariant origins, dating back to 40 Ma. Recent studies, however, suggest that much of Sulawesi's fauna assembled over the last 15 Myr. Here, we test the hypothesis that more recent uplift of previously submerged portions of land on Sulawesi promoted diversification and that much of its faunal assemblage is much younger than the island itself. To do so, we combined palaeogeographical reconstructions with genetic and morphometric datasets derived from Sulawesi's three largest mammals: the babirusa, anoa and Sulawesi warty pig...
April 11, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29618366/bisphosphonate-therapy-for-spinal-osteoporosis-in-hajdu-cheney-syndrome-new-data-and-literature-review
#4
James F H Pittaway, Christopher Harrison, Yumie Rhee, Muriel Holder-Espinasse, Alan E Fryer, Tim Cundy, William M Drake, Melita D Irving
BACKGROUND: Hajdu-Cheney syndrome (HCS) (#OMIM 102500) is a rare, autosomal dominant condition that presents in early childhood. It is caused by mutations in the terminal exon of NOTCH2, which encodes the transmembrane NOTCH2 receptor. This pathway is involved in the coupled processes of bone formation and resorption. The skeletal features of HCS include acro-osteolysis of the digits and osteoporosis commonly affecting vertebrae and long bones. Fractures are a prominent feature and are associated with significant morbidity...
April 4, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29617634/surgical-weight-loss-to-improve-functional-status-trajectories-following-total-knee-arthroplasty-swift-trial-rationale-design-and-methods
#5
Peter N Benotti, Christopher D Still, G Craig Wood, Jamie L Seiler, Christopher J Seiler, Shane P Thomas, Anthony T Petrick, Michael Suk, Brian A Irving
Total Knee Arthroplasty (TKA, also known as total knee replacement) is a highly effective surgical intervention for the restoration of physical function and improving quality of life in patients with disabling knee osteoarthritis. Recent data suggest that obesity is a major risk factor in the pathogenesis and progression of knee osteoarthritis, with increases in body mass index (BMI, kg/m2 ) directly correlating with the prevalence of knee osteoarthritis. However, recent data also suggest that there are increased risks associated with TKAs when performed in patients with morbid obesity (BMI > 40 kg/m2 )...
April 1, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29615488/development-and-clinical-validation-of-the-genedrive-point-of-care-test-for-qualitative-detection-of-hepatitis-c-virus
#6
Alba Llibre, Yusuke Shimakawa, Estelle Mottez, Shaun Ainsworth, Tan-Phuc Buivan, Rick Firth, Elliott Harrison, Arielle R Rosenberg, Jean-François Meritet, Arnaud Fontanet, Pablo Castan, Antonio Madejón, Mark Laverick, Allison Glass, Raquel Viana, Stanislas Pol, C Patrick McClure, William Lucien Irving, Gino Miele, Matthew L Albert, Darragh Duffy
OBJECTIVE: Recently approved direct acting antivirals provide transformative therapies for chronic hepatitis C virus (HCV) infection. The major clinical challenge remains to identify the undiagnosed patients worldwide, many of whom live in low-income and middle-income countries, where access to nucleic acid testing remains limited. The aim of this study was to develop and validate a point-of-care (PoC) assay for the qualitative detection of HCV RNA. DESIGN: We developed a PoC assay for the qualitative detection of HCV RNA on the PCR Genedrive instrument...
April 3, 2018: Gut
https://www.readbyqxmd.com/read/29615005/improving-risk-prediction-accuracy-for-new-soldiers-in-the-u-s-army-by-adding-self-report-survey-data-to-administrative-data
#7
Samantha L Bernecker, Anthony J Rosellini, Matthew K Nock, Wai Tat Chiu, Peter M Gutierrez, Irving Hwang, Thomas E Joiner, James A Naifeh, Nancy A Sampson, Alan M Zaslavsky, Murray B Stein, Robert J Ursano, Ronald C Kessler
BACKGROUND: High rates of mental disorders, suicidality, and interpersonal violence early in the military career have raised interest in implementing preventive interventions with high-risk new enlistees. The Army Study to Assess Risk and Resilience in Servicemembers (STARRS) developed risk-targeting systems for these outcomes based on machine learning methods using administrative data predictors. However, administrative data omit many risk factors, raising the question whether risk targeting could be improved by adding self-report survey data to prediction models...
April 3, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29614083/optimizing-prevention-of-hiv-mother-to-child-transmission-duration-of-antiretroviral-therapy-and-viral-suppression-at-delivery-among-pregnant-malawian-women
#8
Maganizo B Chagomerana, William C Miller, Jennifer H Tang, Irving F Hoffman, Bryan C Mthiko, Jacob Phulusa, Mathias John, Allan Jumbe, Mina C Hosseinipour
BACKGROUND: Effective antiretroviral therapy during pregnancy minimizes the risk of vertical HIV transmission. Some women present late in their pregnancy for first antenatal visit; whether these women achieve viral suppression by delivery and how suppression varies with time on ART is unclear. METHODS: We conducted a prospective cohort study of HIV-infected pregnant women initiating antiretroviral therapy for the first time at Bwaila Hospital in Lilongwe, Malawi from June 2015 to November 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29609890/increasing-circulating-sphingosine-1-phosphate-attenuates-lung-injury-during-ex-vivo-lung-perfusion
#9
J Hunter Mehaffey, Eric J Charles, Adishesh K Narahari, Sarah Schubert, Victor E Laubach, Nicholas R Teman, Kevin R Lynch, Irving L Kron, Ashish K Sharma
BACKGROUND: Sphingosine-1-phosphate regulates endothelial barrier integrity and promotes cell survival and proliferation. We hypothesized that upregulation of sphingosine-1-phosphate during ex vivo lung perfusion would attenuate acute lung injury and improve graft function. METHODS: C57BL/6 mice (n = 4-8/group) were euthanized, followed by 1 hour of warm ischemia and 1 hour of cold preservation in a model of donation after cardiac death. Subsequently, mice underwent 1 hour of ex vivo lung perfusion with 1 of 4 different perfusion solutions: Steen solution (Steen, control arm), Steen with added sphingosine-1-phosphate (Steen + sphingosine-1-phosphate), Steen plus a selective sphingosine kinase 2 inhibitor (Steen + sphingosine kinase inhibitor), or Steen plus both additives (Steen + sphingosine-1-phosphate + sphingosine kinase inhibitor)...
March 11, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29607034/projected-effects-of-climate-change-induced-flow-alterations-on-stream-macroinvertebrate-abundances
#10
Karan Kakouei, Jens Kiesel, Sami Domisch, Katie S Irving, Sonja C Jähnig, Jochem Kail
Global change has the potential to affect river flow conditions which are fundamental determinants of physical habitats. Predictions of the effects of flow alterations on aquatic biota have mostly been assessed based on species ecological traits (e.g., current preferences), which are difficult to link to quantitative discharge data. Alternatively, we used empirically derived predictive relationships for species' response to flow to assess the effect of flow alterations due to climate change in two contrasting central European river catchments...
March 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29605718/a-novel-mouse-model-of-intervertebral-disc-degeneration-shows-altered-cell-fate-and-matrix-homeostasis
#11
Hyowon Choi, Steven Tessier, Elizabeth S Silagi, Rutvin Kyada, Farzad Yousefi, Nancy Pleshko, Irving M Shapiro, Makarand V Risbud
Intervertebral disc degeneration and associated low back and neck pain is a ubiquitous health condition that affects millions of people world-wide, and causes high incidence of disability and enormous medical/societal costs. However, lack of appropriate small animal models with spontaneous disease onset has impeded our ability to understand the pathogenetic mechanisms that characterize and drive the degenerative process. We report, for the first time, early onset spontaneous disc degeneration in SM/J mice known for their poor regenerative capacities compared to "super-healer" LG/J mice...
March 29, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29601485/biopsychosocial-assessment-of-pain-with-thermal-imaging-of-emotional-facial-expression-in-breast-cancer-survivors
#12
David Alberto Rodríguez Medina, Benjamín Domínguez Trejo, Patricia Cortés Esteban, Irving Armando Cruz Albarrán, Luis Alberto Morales Hernández, Gerardo Leija Alva
Background : Recent research has evaluated psychological and biological characteristics associated with pain in survivors of breast cancer (BC). Few studies consider their relationship with inflammatory activity. Voluntary facial expressions modify the autonomic activity and this may be useful in the hospital environment for clinical biopsychosocial assessment of pain. Methods: This research compared a BC survivors group under integral treatment (Oncology, Psychology, Nutrition) with a control group to assess the intensity of pain, behavioral interference, anxiety, depression, temperament-expression, anger control, social isolation, emotional regulation, and alexithymia and inflammatory activity, with salivary interleukin 6 (IL-6)...
March 30, 2018: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29590632/vitamin-d-deficiency-in-the-apc-pirc-rat-does-not-exacerbate-colonic-tumorigenesis-while-low-dietary-calcium-might-be-protective
#13
Amy A Irving, Elizabeth G Duchow, Lori A Plum, Hector F DeLuca
Human studies have shown that individuals with colon cancer tend to have lower serum 25-hydroxy-vitamin D3 [25(OH)D3 ] levels compared with healthy controls, but whether this link is causative, a result of the disease or an indicator of another factor altogether has yet to be demonstrated. In humans, vitamin D, calcium and UV exposure are inextricably linked; therefore, understanding the individual and combined roles of each of these will require animal models specifically designed to address these questions...
March 7, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29582071/vaccination-patterns-in-children-after-autism-spectrum-disorder-diagnosis-and-in-their-younger-siblings
#14
Ousseny Zerbo, Sharareh Modaressi, Kristin Goddard, Edwin Lewis, Bruce H Fireman, Matthew F Daley, Stephanie A Irving, Lisa A Jackson, James G Donahue, Lei Qian, Darios Getahun, Frank DeStefano, Michael M McNeil, Nicola P Klein
Importance: In recent years, rates of vaccination have been declining. Whether this phenomenon disproportionately affects children with autism spectrum disorder (ASD) or their younger siblings is unknown. Objectives: To investigate if children after receiving an ASD diagnosis obtain their remaining scheduled vaccines according to the Advisory Committee on Immunization Practices (ACIP) recommendations and to compare the vaccination patterns of younger siblings of children with ASD with the vaccination patterns of younger siblings of children without ASD...
March 26, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29577930/need-for-permanent-pacemaker-after-surgical-aortic-valve-replacement-reduces-long-term-survival
#15
J Hunter Mehaffey, Nathan S Haywood, Robert B Hawkins, John A Kern, Nicholas R Teman, Irving L Kron, Leora T Yarboro, Gorav Ailawadi
BACKGROUND: Permanent pacemaker (PPM) has been touted as an inconsequential complication following Transcatheter Aortic Valve Replacement (TAVR). As TAVR moves to lower risk patients, the long-term implications remain poorly understood; therefore we evaluated the long-term outcomes of pacemaker in Surgical Aortic Valve Replacement (SAVR) patients. METHODS: A total of 2,600 consecutive patients undergoing SAVR over the past 15 years were reviewed using an institutional Society of Thoracic Surgeons (STS) database and social security death records...
March 22, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29575490/important-patient-and-public-ppi-perspectives-on-addiction-as-a-reason-for-performing-euthanasia
#16
Andy Irving
No abstract text is available yet for this article.
March 24, 2018: Addiction
https://www.readbyqxmd.com/read/29572376/socioeconomic-status-non-communicable-disease-risk-factors-and-walking-speed-in-older-adults-multi-cohort-population-based-study
#17
MULTICENTER STUDY
Silvia Stringhini, Cristian Carmeli, Markus Jokela, Mauricio Avendaño, Cathal McCrory, Angelo d'Errico, Murielle Bochud, Henrique Barros, Giuseppe Costa, Marc Chadeau-Hyam, Cyrille Delpierre, Martina Gandini, Silvia Fraga, Marcel Goldberg, Graham G Giles, Camille Lassale, Rose Anne Kenny, Michelle Kelly-Irving, Fred Paccaud, Richard Layte, Peter Muennig, Michael G Marmot, Ana Isabel Ribeiro, Gianluca Severi, Andrew Steptoe, Martin J Shipley, Marie Zins, Johan P Mackenbach, Paolo Vineis, Mika Kivimäki
OBJECTIVE: To assess the association of low socioeconomic status and risk factors for non-communicable diseases (diabetes, high alcohol intake, high blood pressure, obesity, physical inactivity, smoking) with loss of physical functioning at older ages. DESIGN: Multi-cohort population based study. SETTING: 37 cohort studies from 24 countries in Europe, the United States, Latin America, Africa, and Asia, 1990-2017. PARTICIPANTS: 109 107 men and women aged 45-90 years...
March 23, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29567041/refractive-error-magnitude-and-variability-relation-to-age
#18
Elizabeth L Irving, Carolyn M Machan, Sharon Lam, Patricia K Hrynchak, Linda Lillakas
PURPOSE: To investigate mean ocular refraction (MOR) and astigmatism, over the human age range and compare severity of refractive error to earlier studies from clinical populations having large age ranges. METHODS: For this descriptive study patient age, refractive error and history of surgery affecting refraction were abstracted from the Waterloo Eye Study database (WatES). Average MOR, standard deviation of MOR and astigmatism were assessed in relation to age...
March 19, 2018: Journal of Optometry
https://www.readbyqxmd.com/read/29566844/associations-of-smoking-physical-inactivity-heavy-drinking-and-obesity-with-quality-adjusted-life-expectancy-among-us-adults-with-depression
#19
Haomiao Jia, Matthew M Zack, Irving I Gottesman, William W Thompson
OBJECTIVES: To examine associations between four health behaviors (smoking, physical inactivity, heavy alcohol drinking, and obesity) and three health indices (health-related quality of life, life expectancy, and quality-adjusted life expectancy (QALE)) among US adults with depression. METHODS: Data were obtained from the 2006, 2008, and 2010 Behavioral Risk Factor Surveillance System data. The EuroQol five-dimensional questionnaire (EQ-5D) health preference scores were estimated on the basis of extrapolations from the Centers for Disease Control and Prevention's healthy days measures...
March 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29563072/d-serine-is-a-potential-biomarker-for-clinical-response-in-treatment-of-post-traumatic-stress-disorder-using-r-s-ketamine-infusion-and-timber-psychotherapy-a-pilot-study
#20
Basant Pradhan, Ludmil Mitrev, Ruin Moaddell, Irving W Wainer
Post-traumatic stress disorder (PTSD) is a chronic and debilitating condition that is often refractory to standard frontline antidepressant therapy. A promising new approach to PTSD therapy is administration of a single sub-anesthetic dose of (R,S)-ketamine (Ket). The treatment produces rapid and significant therapeutic response, which lasts for only 4-7 days. In one of our studies, the mean duration of response was increased to 33 days when Ket administration was combined with a mindfulness-based cognitive therapy, Trauma Interventions using Mindfulness Based Extinction and Reconsolidation (TIMBER)...
March 18, 2018: Biochimica et Biophysica Acta
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