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https://www.readbyqxmd.com/read/28815915/synthesis-and-characterization-of-iridium-v-coordination-complexes-with-an-n-o-donor-organic-ligand
#1
Liam Sharninghausen, Shashi Bhushan Sinha, Dimitar Y Shopov, Brandon Q Mercado, David Balcells, Gary W Brudvig, Robert H Crabtree
We have prepared and fully characterized two isomers of [IrIV(dpyp)2] (dpyp = meso-2,4-di(2-pyridynyl)-2,4-pentanediolate). These complexes can be cleanly oxidized to [IrV(dpyp)2]+, which to our knowledge represent the first coordination complexes of Ir(V) in an N,O-donor environment. One isomer has been fully characterized in the Ir(V) state, including by x-ray crystallography, XPS, and DFT calculations, all of which support metal-centered oxidation. The unprecedented stability of these Ir(V) complexes is ascribed to the exceptional donor strength of the ligands, their resistance to oxidative degradation, and the presence of four highly donor alkoxide groups in a plane, which breaks the degeneracy of the d-orbitals and favors oxidation...
August 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28802872/smoking-and-binge-drinking-among-adolescents-ontario-canada-does-the-school-neighbourhood-matter
#2
Kristian Larsen, Teresa To, Hyacinth M Irving, Angela Boak, Hayley A Hamilton, Robert E Mann, Robert Schwartz, Guy E J Faulkner
This study examines whether access to alcohol and tobacco around the school relates to higher or lower odds of cigarette smoking and binge-drinking among Ontario high school students. The 2013 Ontario Student Drug Use and Health Survey provides data on self-reported smoking and drinking, individual covariates and subjective socio-economic status for 6142 students (grades 9-12) in Ontario, Canada. Locations of schools were geocoded and 1.6km network buffers defined the school neighbourhoods. Multi-level logistic regression examines individual and school neighbourhood factors with smoking and binge drinking as the dependent variable...
August 10, 2017: Health & Place
https://www.readbyqxmd.com/read/28800955/preface
#3
EDITORIAL
Vincenza Andrisano, Manuela Bartolini, Daniele Tedesco, Irving W Wainer
No abstract text is available yet for this article.
September 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28798907/building-sustainable-partnerships-to-strengthen-pediatric-capacity-at-a-government-hospital-in-malawi
#4
Michelle Eckerle, Heather L Crouse, Msandeni Chiume, Ajib Phiri, Peter N Kazembe, Hanny Friesen, Tisungane Mvalo, Marideth C Rus, Elizabeth F Fitzgerald, Allyson McKenney, Irving F Hoffman, Megan Coe, Beatrice M Mkandawire, Charles Schubert
INTRODUCTION: To achieve sustained reductions in child mortality in low- and middle-income countries, increased local capacity is necessary. One approach to capacity building is support offered via partnerships with institutions in high-income countries. However, lack of cooperation between institutions can create barriers to successful implementation of programs and may inadvertently weaken the health system they are striving to improve. A coordinated approach is necessary. BACKGROUND: Three U...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28796613/segmentation-of-vasculature-from-fluorescently-labeled-endothelial-cells-in-multi-photon-microscopy-images
#5
Russell Bates, Benjamin Irving, Bostjan Markelc, Jakob Kaeppler, Graham Brown, Ruth J Muschel, Sir Michael Brady, Vicente Grau, Julia A Schnabel
Vasculature is known to be of key biological significance, especially in the study of tumors. As such, considerable effort has been focused on the automated segmentation of vasculature in medical and pre-clinical images. The majority of vascular segmentation methods focus on bloodpool labeling methods, however, particularly in the study of tumors it is of particular interest to be able to visualize both perfused and non-perfused vasculature. Imaging vasculature by highlighting the endothelium provides a way to separate the morphology of vasculature from the potentially confounding factor of perfusion...
August 9, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28793859/investigating-knockdown-resistance-kdr-mechanism-against-pyrethroids-ddt-in-the-malaria-vector-anopheles-funestus-across-africa
#6
Helen Irving, Charles S Wondji
BACKGROUND: Understanding the molecular basis of insecticide resistance is key to improve the surveillance and monitoring of malaria vector populations under control. In the major malaria vector Anopheles funestus, little is currently known about the role of the knockdown resistance (kdr) mechanism. Here, we investigated the presence and contribution of knockdown resistance (kdr) to pyrethroids/DDT resistance observed in Anopheles funestus across Africa. RESULTS: Pyrosequencing genotyping and sequencing of the voltage gated sodium channel (VGSC) gene did not detect the common L1014F mutation in field collected An...
August 9, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28793350/ifnar2-dependent-gene-expression-profile-induced-by-ifn-%C3%AE-in-pteropus-alecto-bat-cells-and-impact-of-ifnar2-knockout-on-virus-infection
#7
Qian Zhang, Lei-Ping Zeng, Peng Zhou, Aaron T Irving, Shang Li, Zheng-Li Shi, Lin-Fa Wang
Bats are important reservoirs of many viruses, which are capable of infecting the host without inducing obvious clinical diseases. Interferon and the downstream interferon regulated genes (IRGs) are known to act as the first line of defense against viral infections. Little is known about the transcriptional profile of genes being induced by interferon in bats and their role in controlling virus infection. In this study, we constructed IFNAR2 knockout bat cell lines using CRISPR technology and further characterized gene expression profiles induced by the most abundant IFN-α (IFN-α3)...
2017: PloS One
https://www.readbyqxmd.com/read/28776700/significant-range-extensions-for-two-fish-species-at-pitcairn-island-south-pacific
#8
H J Duffy, T B Letessier, R A Irving
A baited videographic survey at Pitcairn Island has significantly extended the known range for two reef-fish species: blue-lined triggerfish Xanthichthys caeruleolineatus and greater amberjack Seriola dumerili, with an additional minor extension noted for giant trevally Caranx ignobilis. This highlights the importance of further research in this remote, poorly studied island group and provides evidence supplementing the understanding of oceanographic patterns in the South Pacific.
August 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28775306/rts-s-as01-malaria-vaccine-efficacy-is-not-modified-by-seasonal-precipitation-results-from-a-phase-3-randomized-controlled-trial-in-malawi
#9
Larry Han, Michael G Hudgens, Michael E Emch, Jonathan J Juliano, Corinna Keeler, Francis Martinson, Portia Kamthunzi, Gerald Tegha, Marc Lievens, Irving F Hoffman
The World Health Organization has selected Malawi as one of three sites to pilot the roll-out of RTS,S/AS01 in phase 4 trials. As policy discussions for the expanded use of RTS,S/AS01 continue, it will be critical to determine the performance of the vaccine according to seasonal patterns of malaria transmission in regions of Africa. Given waning vaccine efficacy over time, this secondary analysis demonstrates that administering the vaccine to children in the months prior to malaria season could maximize impact of the vaccine...
August 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28774307/perspectives-of-policy-and-political-decision-makers-on-access-to-formal-dementia-care-expert-interviews-in-eight-european-countries
#10
Anja Broda, Anja Bieber, Gabriele Meyer, Louise Hopper, Rachael Joyce, Kate Irving, Orazio Zanetti, Elisa Portolani, Liselot Kerpershoek, Frans Verhey, Marjolein de Vugt, Claire Wolfs, Siren Eriksen, Janne Røsvik, Maria J Marques, Manuel Gonçalves-Pereira, Britt-Marie Sjölund, Bob Woods, Hannah Jelley, Martin Orrell, Astrid Stephan
BACKGROUND: As part of the ActifCare (ACcess to Timely Formal Care) project, we conducted expert interviews in eight European countries with policy and political decision makers, or representatives of relevant institutions, to determine their perspectives on access to formal care for people with dementia and their carers. METHODS: Each ActifCare country (Germany, Ireland, Italy, The Netherlands, Norway, Portugal, Sweden, United Kingdom) conducted semi-structured interviews with 4-7 experts (total N = 38)...
August 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28770324/impact-of-metformin-on-cardiovascular-disease-a-meta-analysis-of-randomised-trials-among-people-with-type-2-diabetes
#11
REVIEW
Simon J Griffin, James K Leaver, Greg J Irving
AIMS/HYPOTHESIS: Metformin is the most-prescribed oral medication to lower blood glucose worldwide. Yet previous systematic reviews have raised doubts about its effectiveness in reducing risk of cardiovascular disease, the most costly complication of type 2 diabetes. We aimed to systematically identify and pool randomised trials reporting cardiovascular outcomes in which the effect of metformin was 'isolated' through comparison to diet, lifestyle or placebo. METHODS: We performed an electronic literature search of MEDLINE, EMBASE and the Cochrane Library...
August 2, 2017: Diabetologia
https://www.readbyqxmd.com/read/28765440/teaching-cultural-competence-in-dental-education-a-systematic-review-and-exploration-of-implications-for-indigenous-populations-in-australia
#12
REVIEW
Cathryn J Forsyth, Michelle J Irving, Marc Tennant, Stephanie D Short, John A Gilroy
Indigenous and other minority populations worldwide experience higher rates of disease including poor oral health than other populations. Cultural competence of practitioners is increasingly being recognized as fundamental to health care and quality of life in addressing these disparities. The aims of this study were to conduct a systematic review of the literature about teaching cultural competence in dental education and to explore the particular relevance of that teaching for the oral health care of Indigenous populations in Australia...
August 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/28763154/best-practices-in-peri-operative-management-of-patients-with-skeletal-dysplasias
#13
Klane K White, Viviana Bompadre, Michael J Goldberg, Michael B Bober, Tae-Joon Cho, Julie E Hoover-Fong, Melita Irving, William G Mackenzie, Shawn E Kamps, Cathleen Raggio, Gregory J Redding, Samantha S Spencer, Ravi Savarirayan, Mary C Theroux
Patients with skeletal dysplasia frequently require surgery. This patient population has an increased risk for peri-operative complications related to the anatomy of their upper airway, abnormalities of tracheal-bronchial morphology and function; deformity of their chest wall; abnormal mobility of their upper cervical spine; and associated issues with general health and body habitus. Utilizing evidence analysis and expert opinion, this study aims to describe best practices regarding the peri-operative management of patients with skeletal dysplasia...
August 1, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28763070/-knowledge-of-vector-borne-diseases-dengue-rickettsiosis-and-chagas-disease-in-physicians
#14
César I Lugo-Caballero, Karla Dzul-Rosado, Irving Dzul-Tut, Ángel Balam-May, Jorge Zavala-Castro
BACKGROUND: The ecological conditions of Yucatan made it a suitable region for the acquisition of vector-borne diseases such as dengue, rickettsiosis, and Chagas disease. As the epidemiological burden of these diseases shows an alarming increase of severe cases, the early establishment of diagnosis and therapeutics by first-contact physicians is a critical step that is not being fulfilled due to several reasons, including poor knowledge. OBJECTIVE: To determine the level of knowledge related to dengue, Chagas disease, and rickettsiosis among rural first-contact physicians of Yucatan...
May 2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/28760961/autonomous-reciprocating-migration-of-an-active-material
#15
Lin Ren, Meng Wang, Changwei Pan, Qingyu Gao, Yang Liu, Irving R Epstein
Periodic to-and-fro migration is a sophisticated mode of locomotion found in many forms of active matter in nature. Providing a general description of periodic migration is challenging, because many details of animal migration remain a mystery. We study periodic migration in a simpler system using a mechanistic model of a photosensitive, active material in which a stimulus-responsive polymer gel is propelled by chemical waves under the regulation of an illumination gradient sensed by the gel, which plays a role analogous to the environment in periodic animal migration...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28759371/beyond-bad-luck-induced-mutations-and-hallmarks-of-cancer
#16
Michelle Kelly-Irving, Cyrille Delpierre, Paolo Vineis
No abstract text is available yet for this article.
August 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28754951/mass-spectrometry-based-determination-of-kallikrein-related-peptidase-7-klk7-cleavage-preferences-and-subsite-dependency
#17
Lakmali Munasinghage Silva, Thomas Stoll, Thomas Kryza, Carson Ryan Stephens, Marcus Lachlan Hastie, Helen Frances Irving-Rodgers, Ying Dong, Jeffrey John Gorman, Judith Ann Clements
The cleavage preferences of Kallikrein-related peptidase 7 (KLK7) have previously been delineated using synthetic peptide libraries of fixed length, or single protein chains and have suggested that KLK7 exerts a chymotryptic-like cleavage preference. Due to the short length of the peptides utilised, only a limited number of subsites have however been assessed. To determine the subsite preferences of KLK7 in a global setting, we used a mass spectrometry (MS)-based in-depth proteomics approach that utilises human proteome-derived peptide libraries of varying length, termed Proteomic Identification of protease Cleavage Sites (PICS)...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28753631/enhancement-of-early-warning-properties-in-the-kuramoto-model-and-in-an-atrial-fibrillation-model-due-to-an-external-perturbation-of-the-system
#18
David García-Gudiño, Emmanuel Landa, Joel Mendoza-Temis, Alondra Albarado-Ibañez, Juan C Toledo-Roy, Irving O Morales, Alejandro Frank
When a complex dynamical system is externally disturbed, the statistical moments of signals associated to it can be affected in ways that depend on the nature and amplitude of the perturbation. In systems that exhibit phase transitions, the statistical moments can be used as Early Warnings (EW) of the transition. A natural question is thus to wonder what effect external disturbances have on the EWs of system. In this work we study the impact of external noise added to the system on the EWs, with particular focus on understanding the importance of the amplitude and complexity of the noise...
2017: PloS One
https://www.readbyqxmd.com/read/28752518/the-color-of-cancer-margin-guidance-for-oral-cancer-resection-using-elastic-scattering-spectroscopy
#19
Gregory A Grillone, Zimmern Wang, Gintas P Krisciunas, Angela C Tsai, Vishnu R Kannabiran, Robert W Pistey, Qing Zhao, Eladio Rodriguez-Diaz, Ousama M A'Amar, Irving J Bigio
OBJECTIVES/HYPOTHESIS: To evaluate the usefulness of elastic scattering spectroscopy (ESS) as a diagnostic adjunct to frozen section analysis in patients with diagnosed squamous cell carcinoma of the oral cavity. STUDY DESIGN: Prospective analytic study. METHODS: Subjects for this single institution, institutional review board-approved study were recruited from among patients undergoing surgical resection for squamous cell cancer of the oral cavity...
July 28, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28752464/electrophoresis-and-fret-based-measures-of-serpin-polymerization
#20
Sarah V Faull, Anwen E Brown, Imran Haq, James A Irving
Many serpinopathies, including alpha-1 antitrypsin (A1AT) deficiency, are associated with the formation of unbranched polymer chains of mutant serpins. In vivo, this deficiency is the result of mutations that cause kinetic or thermodynamic destabilization of the molecule. However, polymerization can also be induced in vitro from mutant or wild-type serpins under destabilizing conditions. The characteristics of the resulting polymers are dependent upon induction conditions. Due to their relationship to disease, serpin polymers, mainly those formed from A1AT, have been widely studied...
2017: Methods in Molecular Biology
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