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https://www.readbyqxmd.com/read/28229860/distinct-contributions-of-the-thin-and-thick-filaments-to-length-dependent-activation-in-heart-muscle
#1
Xuemeng Zhang, Thomas Kampourakis, Ziqian Yan, Ivanka Sevrieva, Malcolm Irving, Yin-Biao Sun
The Frank-Starling relation is a fundamental auto-regulatory property of the heart that ensures the volume of blood ejected in each heartbeat is matched to the extent of venous filling. At the cellular level, heart muscle cells generate higher force when stretched, but despite intense efforts the underlying molecular mechanism remains unknown. We applied a fluorescence-based method, which reports structural changes separately in the thick and thin filaments of rat cardiac muscle, to elucidate that mechanism...
February 23, 2017: ELife
https://www.readbyqxmd.com/read/28224997/clonal-reversal-of-ageing-associated-stem-cell-lineage-bias-via-a-pluripotent-intermediate
#2
Martin Wahlestedt, Eva Erlandsson, Trine Kristiansen, Rong Lu, Cord Brakebusch, Irving L Weissman, Joan Yuan, Javier Martin-Gonzalez, David Bryder
Ageing associates with significant alterations in somatic/adult stem cells and therapies to counteract these might have profound benefits for health. In the blood, haematopoietic stem cell (HSC) ageing is linked to several functional shortcomings. However, besides the recent realization that individual HSCs might be preset differentially already from young age, HSCs might also age asynchronously. Evaluating the prospects for HSC rejuvenation therefore ultimately requires approaching those HSCs that are functionally affected by age...
February 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/28221073/irving-isadore-gottesman-1930-2016
#3
Thomas J Bouchard, Matt McGue
Presents an obituary for Irving Isadore Gottesman who passed away on June 29, 2016, at his home in Edina, Minnesota. Gottesman was a gifted writer and clnician who will be best remembered as a courageous psychologist who "swam against the current" and researched genetic influence on human behavior, especially psychopathology, at a time when it was considered heresy. (PsycINFO Database Record
February 2017: American Psychologist
https://www.readbyqxmd.com/read/28220772/tumour-and-host-cell-pd-l1-is-required-to-mediate-suppression-of-anti-tumour-immunity-in-mice
#4
Janet Lau, Jeanne Cheung, Armando Navarro, Steve Lianoglou, Benjamin Haley, Klara Totpal, Laura Sanders, Hartmut Koeppen, Patrick Caplazi, Jacqueline McBride, Henry Chiu, Rebecca Hong, Jane Grogan, Vincent Javinal, Robert Yauch, Bryan Irving, Marcia Belvin, Ira Mellman, Jeong M Kim, Maike Schmidt
Expression of PD-L1, the ligand for T-cell inhibitory receptor PD-1, is one key immunosuppressive mechanism by which cancer avoids eradication by the immune system. Therapeutic use of blocking antibodies to PD-L1 or its receptor PD-1 has produced unparalleled, durable clinical responses, with highest likelihood of response seen in patients whose tumour or immune cells express PD-L1 before therapy. The significance of PD-L1 expression in each cell type has emerged as a central and controversial unknown in the clinical development of immunotherapeutics...
February 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28220589/pcnl-access-by-urologist-or-interventional-radiologist-practice-and-outcomes-in-the-united-kingdom
#5
James N Armitage, John Withington, Sarah Fowler, William Jg Finch, Neil A Burgess, Stuart O Irving, Jonathan Glass, Oliver J Wiseman
INTRODUCTION AND OBJECTIVE: Obtaining percutaneous access to the renal collecting system is fundamental to safe and effective percutaneous nephrolithotomy (PCNL). Practice varies between countries, hospitals and individual surgeons as to whether access is obtained by a urologist or an interventional radiologist (IR). We compared outcomes of urologist versus IR tracts in the contemporary UK setting. PATIENTS AND METHODS: Data submitted to the British Association of Urological Surgeons (BAUS) PCNL data registry between 2009 and 2015 were analysed according to whether access was obtained by a urologist or an IR...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28219659/dementia-like-pathology-in-type-2-diabetes-a-novel-microrna-mechanism
#6
Anuradha Kalani, Pankaj Chaturvedi, Claudio Maldonado, Philip Bauer, Irving G Joshua, Suresh C Tyagi, Neetu Tyagi
Although type-2 diabetes (T2D) has been reported to increase the risk of cognitive dysfunction and dementia, the underlying mechanisms remain unclear. Dementia-like pathology is attributed to the accumulation of cellular prion protein (PrP(c)) which plays a role in cognitive dysfunction. However, its involvement and regulation in diabetic dementia-like pathology is not well understood. Using T2D db/db (leptin receptor knockout) mice subjected to object recognition and Y-maze behavioral tests, we determined that short-term memory was compromised and that the mice displayed abrupt spontaneous behaviour compared to db/m control mice...
February 17, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28207247/ortho-methoxyphenols-as-convenient-oxidative-bioconjugation-reagents-with-application-to-site-selective-heterobifunctional-crosslinkers
#7
Adel M ElSohly, James Irving MacDonald, Nina B Hentzen, Ioana Laura Aanei, Kareem M El Muslemany, Matthew B Francis
The synthesis of complex protein-based bioconjugates has been facilitated greatly by recent developments in chemoselective methods for biomolecular modification. The oxidative coupling of o-aminophenols or catechols with aniline functional groups is chemoselective, mild, and rapid; however, the oxidatively sensitive nature of the electron-rich aromatics and the paucity of commercial sources pose some obstacles to the general use of these reactive strategies. Herein, we identify o-methoxyphenols as air-stable, commercially available derivatives that undergo efficient oxidative couplings with anilines in the presence of periodate as oxidant...
February 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28205255/effect-of-postnatal-hiv-treatment-on-clinical-mastitis-and-breast-inflammation-in-hiv-infected-breast-feeding-women
#8
Sabrina Zadrozny, Daniel Westreich, Michael G Hudgens, Charles Chasela, Denise J Jamieson, Francis Martinson, Chifundo Zimba, Gerald Tegha, Irving Hoffman, William C Miller, Brian W Pence, Caroline C King, Athena P Kourtis, Wezi Msungama, Charles van der Horst
BACKGROUND: The relationship between mastitis and antiretroviral therapy among HIV-positive, breast-feeding women is unclear. METHODS: In the Breastfeeding, Antiretrovirals, and Nutrition (BAN) study, conducted in Lilongwe, Malawi, 2369 mother-infant pairs were randomized to a nutritional supplement group and to one of three treatment groups: maternal antiretroviral therapy (ART), infant nevirapine (NVP) or standard of care for 24 weeks of exclusive breast-feeding and 4 weeks of weaning...
March 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28203366/sex-differences-in-variability-across-timescales-in-balb-c-mice
#9
Benjamin L Smarr, Azure D Grant, Irving Zucker, Brian J Prendergast, Lance J Kriegsfeld
BACKGROUND: Females are markedly underinvestigated in the biological and behavioral sciences due to the presumption that cyclic hormonal changes across the ovulatory cycle introduce excess variability to measures of interest in comparison to males. However, recent analyses indicate that male and female mice and rats exhibit comparable variability across numerous physiological and behavioral measures, even when the stage of the estrous cycle is not considered. Hormonal changes across the ovulatory cycle likely contribute cyclic, intra-individual variability in females, but the source(s) of male variability has, to our knowledge, not been investigated...
2017: Biology of Sex Differences
https://www.readbyqxmd.com/read/28191507/mapping-the-distribution-of-anopheles-funestus-across-benin-highlights-a-sharp-contrast-of-susceptibility-to-insecticides-and-infection-rate-to-plasmodium-between-southern-and-northern-populations
#10
Rousseau Djouaka, Romaric Akoton, Genevieve M Tchigossou, Seun M Atoyebi, Helen Irving, Michael O Kusimo, Innocent Djegbe, Jacob M Riveron, Eric Tossou, Akadiri Yessoufou, Charles S Wondji
Background. Malaria remains an important public health issue in Benin, with Anopheles gambiae s.l. and Anopheles funestus s.s being the predominant vectors. This study was designed to generate information on An. funestus distribution, molecular speciation, Plasmodium infection rate and insecticide susceptibility status across Benin. Methods. Mosquito samples were collected from December 2014 to January 2016 in 46 localities in Benin. These samples were mapped and An. funestus collected were speciated to the molecular level...
December 14, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28190606/2016-update-to-the-american-association-for-thoracic-surgery-consensus-guidelines-ischemic-mitral-valve-regurgitation
#11
EDITORIAL
Irving L Kron, Damien J LaPar, Michael A Acker, David H Adams, Gorav Ailawadi, Steven F Bolling, Judy W Hung, D Scott Lim, Michael J Mack, Patrick T O'Gara, Michael K Parides, John D Puskas
No abstract text is available yet for this article.
January 17, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28188201/a-day-of-immersive-physiology-experiments-increases-knowledge-and-excitement-towards-physiology-and-scientific-careers-in-native-american-students
#12
Bryan K Becker, Alicia M Schiller, Irving H Zucker, Eric A Eager, Liliana P Bronner, Maurice Godfrey
Underserved minority groups are disproportionately absent from the pursuit of careers in science, technology, engineering, and mathematics (STEM) fields. One such underserved population, Native Americans, are particularly underrepresented in STEM fields. Although recent advocacy and outreach designed toward increasing minority involvement in health care-related occupations have been mostly successful, little is known about the efficacy of outreach programs in increasing minority enthusiasm toward careers in traditional scientific professions...
March 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28188079/current-practices-in-home-management-of-nasogastric-tube-placement-in-pediatric-patients-a-survey-of-parents-and-homecare-providers
#13
LaDonna Northington, Beth Lyman, Peggi Guenter, Sharon Y Irving, Lori Duesing
: Enteral feeding tubes are used in pediatric patients to deliver nutrition, fluids or medications. The literature related to short-term feeding tube (nasogastric [NG], hereafter known as NGT, or orogastric [OGT],) use in pediatric homecare patients is sparse. This descriptive study sought to gather baseline information about these children and how their feeding tubes are managed at home. Specifically, we sought to better understand how the tubes are placed and the method(s) used for tube placement verification...
February 7, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28187105/reply
#14
Claudia Carvalho, Irving Kirsch, Ted J Kaptchuk
No abstract text is available yet for this article.
March 2017: Pain
https://www.readbyqxmd.com/read/28185528/early-warning-signs-fdg-pet-to-diagnose-bleomycin-toxicity
#15
Michael Dickinson, Lou Irving, Michael Hofman
No abstract text is available yet for this article.
May 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28179421/it-s-time-to-redefine-inflammation
#16
REVIEW
Maria Antonelli, Irving Kushner
Inflammation has been defined for many years as the response to tissue injury and infection. We are now forced to reconsider this definition by the avalanche of reports that molecules and cells associated with inflammation are activated or expressed in high concentration in a large variety of states in the absence of tissue injury or infection. Modest increases in concentration of C-reactive protein, a circulating marker of inflammation, have been reported to be associated with an astounding number of conditions and lifestyles felt to be associated with poor health; these conditions represent or reflect minor metabolic stresses...
February 8, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28178072/side-effects-can-enhance-treatment-response-through-expectancy-effects-an-experimental-analgesic-randomized-controlled-trial
#17
Chantal Berna, Irving Kirsch, Sean R Zion, Yvonne C Lee, Karin B Jensen, Pamela Sadler, Ted J Kaptchuk, Robert R Edwards
In randomized controlled trials (RCTs), medication side effects may lead to beliefs that one is receiving the active intervention and enhance active treatment responses, thereby majoring drug-placebo differences. We tested these hypotheses with an experimental double-blind RCT of a nonsteroidal anti-inflammatory medication (NSAID) with and without the addition of atropine to induce side effects. One hundred healthy volunteers were told they would be randomized to either combined analgesics that might produce dry mouth or inert placebos...
February 4, 2017: Pain
https://www.readbyqxmd.com/read/28177752/a-computational-approach-to-studying-protein-folding-problems-considering-the-crucial-role-of-the-intracellular-environment
#18
Pedro P González-Pérez, Daniel J Orta, Irving Peña, Eduardo C Flores, José U Ramírez, Hiram I Beltrán, Salomón J Alas
Intracellular protein folding (PF) is performed in a highly inhomogeneous, crowded, and correlated environment. Due to this inherent complexity, the study and understanding of PF phenomena is a fundamental issue in the field of computational systems biology. In particular, it is important to use a modeled medium that accurately reflects PF in natural systems. In the current study, we present a simulation wherein PF is carried out within an inhomogeneous modeled medium. Simulation resources included a two-dimensional hydrophobic-polar (HP) model, evolutionary algorithms, and the dual site-bond model...
February 8, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28175223/n802-improving-care-for-patients-with-perianal-crohn-s-disease-review-of-a-perianal-virtual-clinic
#19
H Yarrow, P Irving, A Williams, F Hibberts, I Koumoutsos, A Darakhshan, E Westcott, J Duncan
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172862/p220-current-practices-in-ileal-pouch-surveillance-for-ulcerative-colitis-patients-in-three-london-ibd-referral-centres
#20
M Kabir, S Morgan, M A Samaan, K Forsyth, J P Segal, S Elkady, A P Z Arenaza, K Kok, E Seward, R Vega, S Di Caro, E Westcott, S Mehta, F Rahman, S McCartney, S L Bloom, M Northover, A Darakhshan, A Williams, S Anderson, J Sanderson, A Hart, P M Irving
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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