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Endolymphatic hydrops

Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone
No abstract text is available yet for this article.
March 7, 2018: Magnetic Resonance in Medical Sciences: MRMS
R Gürkov, J Hornibrook
More than 150 years after its initial description by Prosper Menière, the disease named after him is still at the center of scientific debates. Two recent developments have specifically created a breeding ground for controversy: (1) Since its first description 10 years ago, magnetic resonance imaging diagnosis of endolymphatic hydrops in living patients has seen an increasing and worldwide application. (2) The Bárány Society Classification Committee published diagnostic criteria for Menière's disease in 2015 and proposed a concept of the disease that has elicited widespread criticism...
March 2, 2018: HNO
Takahiro Azuma, Taketoshi Nogaki, Patricia Schachern, Michael M Paparella, Sebahattin Cureoglu
HYPOTHESIS: We hypothesized that there would be significant anatomic differences of the tensor tympani muscle (TTM), tympanic diaphragm, epitympanum, and protympanum in patients with versus without Menière's disease. BACKGROUND: The effects of tenotomy on Menière's disease suggested it relieves the pressure on the inner ear of the contraction of the TTM and of negative middle ear pressure. METHODS: Using human temporal bones from patients with Menière's disease, two studies were conducted...
March 1, 2018: Otology & Neurotology
Gerlig Widmann
Magnetic resonance imaging (MRI) has become an important imaging technique for otorhinolaryngology. The aim of the present CME contribution for ENT physicians is to provide an overview of the advantages and disadvantages as well as the possibilities of head and neck MRI and to summarize the main clinical applications of the various MRI sequences. Basic sequences (T1w, T2w, T1wC+) and fat suppression sequences (TIRM/STIR, Dixon, Spectral Fat sat) are the basis for evaluating inflammation, congenital lesions and tumors...
March 2018: Laryngo- Rhino- Otologie
Ashraf Elsayed Morgan, Elshahat Ibrahem Ismail, Bassem Ashraf
OBJECTIVE: This study was designed to evaluate the effectiveness of intratympanic dexamethazone (ITD) for the treatment of ipsilateral delayed endolymphatic hydrops (DEH). METHODS: Forty-one patients were diagnosed with ipsilateral DEH. Only 37 patients completed this study. Patients were randomly divided into 2 groups. Group A (n = 16) received oral medication, and group B (n = 21) received ITD once weekly for 4 consecutive weeks. RESULTS: In group A, 6 patients showed improvement in their vertigo...
February 16, 2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
Marc-Henri Asmar, Louis Gaboury, Issam Saliba
Objectives Endolymphatic sac (ELS) pathophysiology in Ménière's disease (MD) remains poorly understood. We identified from the literature a group of proteins expressed on the ELS and involved in endolymph volume regulation: aquaporin-2 (AQP2), vasopressin receptor V2R, sodium potassium chloride cotransporter 2 (NKCC2), and transient receptor potential cation channel V4 (TRPV4). Our objective was to determine whether their ELS expression was altered in MD, to better understand the pathophysiology of endolymphatic hydrops...
February 1, 2018: Otolaryngology—Head and Neck Surgery
David Dornbos, H Jeffrey Kim, John A Butman, Russell R Lonser
Importance: von Hippel-Lindau (VHL) disease-associated central nervous system (CNS) lesions include hemangioblastomas and endolymphatic sac tumors (ELSTs), which are associated with significant neurological morbidity and mortality. Recent studies provide critical new biological, diagnostic, and management insights into these tumors. Observations: Biological features, natural history, clinical findings, and management strategies of VHL disease-associated CNS tumors are reviewed...
January 29, 2018: JAMA Neurology
Maxime Maheu, Salman F Alhabib, Simon P Landry, Marc Elie Nader, François Champoux, Issam Saliba
OBJECTIVE: 1) To determine if unexplained ear fullness might be a symptom of endolymphatic hydrops (EH) by using Electrocochleography (ECochG) SP/AP area and amplitude ratios. 2) To assess if individuals with unexplained ear fullness without vertigo differ significantly from individuals with ear fullness due to Ménière's disease (MD). MATERIALS AND METHODS: In a case-control study in our tertiary care center, we evaluated 62 ears across 49 patients, including 18 normal healthy ears across 12 control patients, 26 ears with unexplained ear fullness across 20 patients (6 had bilateral symptoms of ear fullness), and 18 ears with definite MD across 17 patients (1 bilateral disease)...
December 2017: Journal of International Advanced Otology
Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
PURPOSE: To elucidate differences between the perivascular space (PVS) in the basal ganglia (BG) versus that found in white matter (WM) using heavily T2-weighted FLAIR (hT2-FL) in terms of 1) signal intensity on non-contrast enhanced images, and 2) the degree of contrast enhancement by intravenous single dose administration of gadolinium based contrast agent (IV-SD-GBCA). MATERIALS AND METHODS: Eight healthy men and 13 patients with suspected endolymphatic hydrops were included...
January 18, 2018: Magnetic Resonance in Medical Sciences: MRMS
Massimo Ralli, Antonio Greco, Giancarlo Altissimi, Rosaria Turchetta, Lucia Longo, Vittorio D'Aguanno, Mario Tombolini, Giancarlo Cianfrone, Marco de Vincentiis
Vestibular schwannoma and endolymphatic hydrops are two conditions that may present with similar audio-vestibular symptoms. The association of the two in the same patient represents an unusual finding that may lead clinicians to errors and delays in diagnosis and clinical management of affected subjects. We discuss the case of a patient with an intrameatal vestibular schwannoma reporting symptoms suggestive for ipsilateral endolymphatic hydrops. The patient presented with fluctuating hearing loss, tinnitus, and acute rotatory vertigo episodes, and underwent a full audiological evaluation and imaging of the brain with contrast-enhanced Magnetic Resonance Imaging...
December 1, 2017: International Tinnitus Journal
Li-Yuan Jiang, Jiao-Jun He, Xi-Xi Chen, Xue-Jiao Sun, Xue-Zhong Wang, Shan Zhong, Hua-de Chen
OBJECTIVE: To investigate the effects of electroacupuncture (EA) on endolymphatic hydrops (EH) and the regulation of arginine vasopressin (AVP)-aquaporin-2 (AQP2) pathway in guinea pigs. METHODS: EH was induced in male guinea pigs by an intraperitoneal injection of AVP. For the treatment, EA was delivered to Baihui (GV 20) and Tinggong (SI 19) acupoints, once per day for 10 consecutive days. In histomorphological studies, cochlear hydrops degree was evaluated by hematoxylin-eosin (HE) staining, and then the ratio of scala media (SM) area to SM + scala vestibuli (SV) area (R value) was calculated...
January 15, 2018: Chinese Journal of Integrative Medicine
Claudia Jerin, Sonja Floerke, Rebecca Maxwell, Robert Gürkov
OBJECTIVE: To characterize the short-, middle-, and long-term occurrence of vertigo attacks in a large population of Menière's disease (MD) and to investigate the relationship between the extent of endolymphatic hydrops (ELH) and the severity of audiovestibular symptoms. STUDY DESIGN: Prospective observational study. METHODS: One hundred ninety-two patients with clinically definite MD participated in this study. The degree of ELH was visualized by locally enhanced inner ear magnetic resonance imaging...
February 2018: Otology & Neurotology
Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda
Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design: Prospective, single-arm repeated measures. Methods: Eleven MD patients were enrolled...
December 2017: Laryngoscope Investigative Otolaryngology
Shiyin Yang, Huaming Zhu, Bijun Zhu, Hui Wang, Zhengnong Chen, Yaqin Wu, Bin Chen, Haibo Shi, Yuehua Li, Jing Zou, Shankai Yin
OBJECTIVE: This study was performed to reevaluate the diagnostic significance of clinically well-accepted audiological tests in indicating endolymphatic hydrops (EH) in Menière's disease (MD). STUDY DESIGN: Retrospective case review. SETTINGS: Hospital. PATIENTS: Fifty patients (52 affected ears) diagnosed with MD were enrolled. INTERVENTION: Diagnostic. MAIN OUTCOME MEASURE: To analyze the correlations between endolymphatic hydrops and results of audiological test including the pure-tone audiometry threshold, suprathreshold function tests, electrocochleogram, and glycerol test...
December 28, 2017: Otology & Neurotology
Rainer Spiegel, Heiko Rust, Thomas Baumann, Hergen Friedrich, Raoul Sutter, Martina Göldlin, Christiane Rosin, René Müri, Georgios Mantokoudis, Roland Bingisser, Michael Strupp, Roger Kalla
This review provides an update on interdisciplinary treatment for dizziness. Dizziness can have various causes and the treatment offered should depend on the cause. After reading this article, the clinician will have an overview of current treatment recommendations. Recommendations are made for the most prevalent causes of dizziness including acute and chronic vestibular syndromes, vestibular neuritis, benign paroxysmal positional vertigo, endolymphatic hydrops and Menière’s disease, vestibular paroxysmia and vestibular migraine, cardiac causes, transient ischaemic attacks and strokes, episodic ataxia type 2, persistent postural-perceptual dizziness, bilateral vestibulopathy, degenerative, autoimmune and neoplastic diseases, upbeat- and downbeat nystagmus...
December 28, 2017: Swiss Medical Weekly
Leif Erik Walther
Vertigo is a multisensory syndrome that otolaryngologists are confronted with every day. With regard to the complex functions of the sense of orientation, vertigo is considered today as a disorder of the sense of direction, a disturbed spatial perception of the body. Beside the frequent classical syndromes for which vertigo is the leading symptom (e.g. positional vertigo, vestibular neuritis, Menière's disease), vertigo may occur as main or accompanying symptom of a multitude of ENT-related diseases involving the inner ear...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
Wei Li, Yan Lei, Jiang Zhu, Yi Qian, Guo-Ting Ma, Tao Lu, Guo-Hua Hu, Hou-Yong Kang
Endolymphatic hydrops (ELH) is a well-established histological marker of Ménière's Disease (MD). The diagnosis of MD still depends on clinical symptoms complemented with inner ear function tests. Thus far, definitive diagnosis remains difficult. It is necessary for clinicians to explore an objective examination to diagnose MD and to monitor patients' ELH. This article is protected by copyright. All rights reserved.
December 13, 2017: Clinical Otolaryngology
Roxana Moayer, Gail P Ishiyama, Stellios Karnezis, Ali R Sepahdari, Akira Ishiyama
OBJECTIVE: Advances in high resolution magnetic resonance imaging (MRI) have enabled the detection of endolymphatic hydrops (EH), a pathological ballooning of the endolymphatic fluid system, known to be associated with Menière's disease. When a patient has a known diagnosis of vestibular schwannoma and develops recurrent episodic vertigo spells, many surgeons recommend surgical intervention, attributing the vestibular symptoms to the vestibular schwannoma. The aim of this study is to evaluate the clinical outcome in patients with vestibular schwannoma and EH, treated medically, for recurrent spells of vertigo...
January 2018: Otology & Neurotology
Ji Eun Choi, Yi-Kyung Kim, Young Sang Cho, Kieun Lee, Hyun Woo Park, Sung Hoon Yoon, Hyung-Jin Kim, Won-Ho Chung
The purpose of this study was to prove the hypothesis that caloric response in Ménière's disease (MD) is reduced by hydropic expansion of the vestibular labyrinth, not by vestibular hypofunction, by evaluating the correlation morphologically using an intravenous Gadolinium (IV-Gd) inner ear MRI. In study I, the prevalence of abnormal video Head Impulse Test (vHIT) results among the patients with definite unilateral MD (n = 24) and vestibular neuritis (VN) (n = 22) were investigated. All patients showed abnormal canal paresis (CP) (> 26%) on caloric tests...
2017: PloS One
Robert Gürkov
BACKGROUND: Over 75 years ago, endolymphatic hydrops was discovered as the pathologic correlate of Menière's disease. However, this pathologic finding could be ascertained only in postmortem histologic studies. Due to this diagnostic dilemma and the variable manifestation of the various audiovestibular symptoms, diagnostic classification systems based on clinical findings have been used hitherto. METHODS: A review of the literature of magnetic resonance (MR) imaging of hydropic ear disease...
December 2017: Otology & Neurotology
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