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Endolymphatic hydrops

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https://www.readbyqxmd.com/read/29762197/high-frequency-horizontal-semicircular-canal-function-in-certain-meni%C3%A3-re-s-disease
#1
Claudia Jerin, Rebecca Maxwell, Robert Gürkov
OBJECTIVES: To characterize video head impulse testing (vHIT) in definitive Menière's disease and to investigate the relationship between vHIT results and other audiovestibular function tests. DESIGN: Fifty-four patients with certain Menière's disease, that is, patients with clinically definite Menière's disease and endolymphatic hydrops visualized by locally enhanced inner ear MR imaging, were recruited for this study. All patients underwent vHIT. The vestibular-ocular reflex gain at 60 ms and refixation saccades were the outcome parameters measured...
May 14, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29747307/-clinical-features-and-imaging-characteristics-of-meniere-s-disease-verified-by-intravenous-gadolinium-contrast-enhanced-magnetic-resonance-imaging
#2
S M Shi, W F Sun, W Q Wang
Objective: To analyze the clinical features and imaging characteristics of Meniere's disease (MD)verified by intravenous gadolinium contrast-enhanced magnetic resonance imaging(MRI). Methods: A total of 174 patients with Meniere's disease were involved in this study between March 2016 and October 2017. All of them underwent 3D-fluid attenuated inversion recovery (FLAIR) MRI and presented endolymphatic hydrops and clinical characteristics of suspected Meniere's disease. The clinical characteristics, the grades of endolymphatic hydrops (EH) using Nakashima grading standard were analyzed, and the correlation between grade and clinical features was evaluated...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29737749/-recurrent-low-frequency-sensorineural-deafness
#3
REVIEW
Ying Lin, Jin Ling Wang, Fei Sun, Jin Jin Shen, Zhao Xia Wang, Jian Hua Qiu, Ding Jun Zha
Low frequency sensorineural deafness is a common subtype of idiopathic sudden deafness. Certain patients suffered recurrent attacks without vertigo, much alike Meniere's disease. Few of them developed into definite Meniere's disease during long-term follow-up in many clinical studies. Although the pathophysiology of recurrent low frequency deafness is yet unknown, the desease is considered associated with early state of endolymphatic hydrops or migraine. Otologists shall be aware of its clinical course and careful explanation is necessary at time of initial informed consent...
March 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29735658/osmotic-stabilization-prevents-cochlear-synaptopathy-after-blast-trauma
#4
Jinkyung Kim, Anping Xia, Nicolas Grillet, Brian E Applegate, John S Oghalai
Traumatic noise causes hearing loss by damaging sensory hair cells and their auditory synapses. There are no treatments. Here, we investigated mice exposed to a blast wave approximating a roadside bomb. In vivo cochlear imaging revealed an increase in the volume of endolymph, the fluid within scala media, termed endolymphatic hydrops. Endolymphatic hydrops, hair cell loss, and cochlear synaptopathy were initiated by trauma to the mechanosensitive hair cell stereocilia and were K+ -dependent. Increasing the osmolality of the adjacent perilymph treated endolymphatic hydrops and prevented synaptopathy, but did not prevent hair cell loss...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29698363/relationship-between-audio-vestibular-functional-tests-and-inner-ear-mri-in-meniere-s-disease
#5
Raphaële Quatre, Arnaud Attyé, Alexandre Karkas, Agnès Job, Georges Dumas, Sébastien Schmerber
OBJECTIVES: Meniere's disease is an inner ear disorder generally attributed to an endolymphatic hydrops. Different electrophysiological tests and imaging techniques have been developed to improve endolymphatic hydrops diagnosis. The goal of our study was to compare the sensitivity and the specificity of delayed inner ear magnetic resonance imaging (MRI) after intravenous injection of gadolinium with extratympanic clicks electrocochleography (EcochG), phase shift of distortion product otoacoustic emissions (shift-DPOAEs), and cervical vestibular-evoked myogenic potentials (cVEMP) for the diagnosis of Meniere's disease...
April 25, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29557845/endolymphatic-hydrops-a-warning-about-the-interpretation-of-magnetic-resonance-images-without-refreshed-knowledge-of-inner-ear-endolymphatic-structure-anatomy
#6
Arnaud Attyé, Michael Eliezer
No abstract text is available yet for this article.
March 19, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29553505/in-vivo-morphometric-analysis-of-human-cranial-nerves-using-magnetic-resonance-imaging-in-meni%C3%A3-re-s-disease-ears-and-normal-hearing-ears
#7
Wilhelm H Flatz, Annika Henneberger, Maximilian F Reiser, Robert Gürkov, Birgit Ertl-Wagner
Analysis of neural structures in Menière's Disease (MD) is of importance, since a loss of such structures has previously been proposed for this patient group but has yet to be confirmed. This protocol describes a method of in vivo evaluation of neural changes especially well suitable for cranial nerve analysis using magnetic resonance imaging (MRI). MD-patients and normal hearing persons were examined in a 3-T MR-scanner using a scan protocol including strongly T2-weighted 3D gradient-echo-sequence (3D-CISS)...
February 21, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29515085/improved-3d-real-inversion-recovery-a-robust-imaging-technique-for-endolymphatic-hydrops-after-intravenous-administration-of-gadolinium
#8
Shinji Naganawa, Hisashi Kawai, Toshiaki Taoka, Michihiko Sone
No abstract text is available yet for this article.
March 7, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29500497/on-the-classification-of-hydropic-ear-disease-meni%C3%A3-re-s-disease
#9
REVIEW
R Gürkov, J Hornibrook
More than 150 years after its initial description by Prosper Menière, the disease named after him is still at the center of scientific debates. Two recent developments have specifically created a breeding ground for controversy: (1) Since its first description 10 years ago, magnetic resonance imaging diagnosis of endolymphatic hydrops in living patients has seen an increasing and worldwide application. (2) The Bárány Society Classification Committee published diagnostic criteria for Menière's disease in 2015 and proposed a concept of the disease that has elicited widespread criticism...
March 2, 2018: HNO
https://www.readbyqxmd.com/read/29498964/structural-analysis-of-tensor-tympani-muscle-tympanic-diaphragm-epitympanum-and-protympanum-in-meni%C3%A3-re-s-disease-a-human-temporal-bone-study
#10
Takahiro Azuma, Taketoshi Nogaki, Patricia Schachern, Michael M Paparella, Sebahattin Cureoglu
HYPOTHESIS: We hypothesized that there would be significant anatomic differences of the tensor tympani muscle (TTM), tympanic diaphragm, epitympanum, and protympanum in patients with versus without Menière's disease. BACKGROUND: The effects of tenotomy on Menière's disease suggested it relieves the pressure on the inner ear of the contraction of the TTM and of negative middle ear pressure. METHODS: Using human temporal bones from patients with Menière's disease, two studies were conducted...
April 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29495044/-head-neck-mri-what-ent-specialists-should-know
#11
Gerlig Widmann
Magnetic resonance imaging (MRI) has become an important imaging technique for otorhinolaryngology. The aim of the present CME contribution for ENT physicians is to provide an overview of the advantages and disadvantages as well as the possibilities of head and neck MRI and to summarize the main clinical applications of the various MRI sequences. Basic sequences (T1w, T2w, T1wC+) and fat suppression sequences (TIRM/STIR, Dixon, Spectral Fat sat) are the basis for evaluating inflammation, congenital lesions and tumors...
March 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29455211/intratympanic-injections-of-dexamethasone-in-delayed-endolymphatic-hydrops-a-prospective-clinical-study
#12
Ashraf Elsayed Morgan, Elshahat Ibrahem Ismail, Bassem Ashraf
OBJECTIVE: This study was designed to evaluate the effectiveness of intratympanic dexamethazone (ITD) for the treatment of ipsilateral delayed endolymphatic hydrops (DEH). METHODS: Forty-one patients were diagnosed with ipsilateral DEH. Only 37 patients completed this study. Patients were randomly divided into 2 groups. Group A (n = 16) received oral medication, and group B (n = 21) received ITD once weekly for 4 consecutive weeks. RESULTS: In group A, 6 patients showed improvement in their vertigo...
2018: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/29436285/m%C3%A3-ni%C3%A3-re-s-disease-pathophysiology-endolymphatic-sac-immunohistochemical-study-of-aquaporin-2-v2r-vasopressin-receptor-nkcc2-and-trpv4
#13
Marc-Henri Asmar, Louis Gaboury, Issam Saliba
Objectives Endolymphatic sac (ELS) pathophysiology in Ménière's disease (MD) remains poorly understood. We identified from the literature a group of proteins expressed on the ELS and involved in endolymph volume regulation: aquaporin-2 (AQP2), vasopressin receptor V2R, sodium potassium chloride cotransporter 2 (NKCC2), and transient receptor potential cation channel V4 (TRPV4). Our objective was to determine whether their ELS expression was altered in MD, to better understand the pathophysiology of endolymphatic hydrops...
April 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29379961/review-of-the-neurological-implications-of-von-hippel-lindau-disease
#14
David Dornbos, H Jeffrey Kim, John A Butman, Russell R Lonser
Importance: von Hippel-Lindau (VHL) disease-associated central nervous system (CNS) lesions include hemangioblastomas and endolymphatic sac tumors (ELSTs), which are associated with significant neurological morbidity and mortality. Recent studies provide critical new biological, diagnostic, and management insights into these tumors. Observations: Biological features, natural history, clinical findings, and management strategies of VHL disease-associated CNS tumors are reviewed...
January 29, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29360091/ear-fullness-as-a-symptom-of-endolymphatic-hydrops-in-non-m%C3%A3-ni%C3%A3-re-s-patient
#15
Maxime Maheu, Salman F Alhabib, Simon P Landry, Marc Elie Nader, François Champoux, Issam Saliba
OBJECTIVE: 1) To determine if unexplained ear fullness might be a symptom of endolymphatic hydrops (EH) by using Electrocochleography (ECochG) SP/AP area and amplitude ratios. 2) To assess if individuals with unexplained ear fullness without vertigo differ significantly from individuals with ear fullness due to Ménière's disease (MD). MATERIALS AND METHODS: In a case-control study in our tertiary care center, we evaluated 62 ears across 49 patients, including 18 normal healthy ears across 12 control patients, 26 ears with unexplained ear fullness across 20 patients (6 had bilateral symptoms of ear fullness), and 18 ears with definite MD across 17 patients (1 bilateral disease)...
December 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29343658/differences-in-signal-intensity-and-enhancement-on-mr-images-of-the-perivascular-spaces-in-the-basal-ganglia-versus-those-in-white-matter
#16
Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka
PURPOSE: To elucidate differences between the perivascular space (PVS) in the basal ganglia (BG) versus that found in white matter (WM) using heavily T2-weighted FLAIR (hT2-FL) in terms of 1) signal intensity on non-contrast enhanced images, and 2) the degree of contrast enhancement by intravenous single dose administration of gadolinium based contrast agent (IV-SD-GBCA). MATERIALS AND METHODS: Eight healthy men and 13 patients with suspected endolymphatic hydrops were included...
January 18, 2018: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/29336131/vestibular-schwannoma-and-ipsilateral-endolymphatic-hydrops-an-unusual-association
#17
Massimo Ralli, Antonio Greco, Giancarlo Altissimi, Rosaria Turchetta, Lucia Longo, Vittorio D'Aguanno, Mario Tombolini, Giancarlo Cianfrone, Marco de Vincentiis
Vestibular schwannoma and endolymphatic hydrops are two conditions that may present with similar audio-vestibular symptoms. The association of the two in the same patient represents an unusual finding that may lead clinicians to errors and delays in diagnosis and clinical management of affected subjects. We discuss the case of a patient with an intrameatal vestibular schwannoma reporting symptoms suggestive for ipsilateral endolymphatic hydrops. The patient presented with fluctuating hearing loss, tinnitus, and acute rotatory vertigo episodes, and underwent a full audiological evaluation and imaging of the brain with contrast-enhanced Magnetic Resonance Imaging...
December 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/29335859/arginine-vasopressin-aquaporin-2-pathway-mediated-dehydration-effects-of-electroacupuncture-in-guinea-pig-model-of-avp-induced-endolymphatic-hydrops
#18
Li-Yuan Jiang, Jiao-Jun He, Xi-Xi Chen, Xue-Jiao Sun, Xue-Zhong Wang, Shan Zhong, Hua-de Chen
OBJECTIVE: To investigate the effects of electroacupuncture (EA) on endolymphatic hydrops (EH) and the regulation of arginine vasopressin (AVP)-aquaporin-2 (AQP2) pathway in guinea pigs. METHODS: EH was induced in male guinea pigs by an intraperitoneal injection of AVP. For the treatment, EA was delivered to Baihui (GV 20) and Tinggong (SI 19) acupoints, once per day for 10 consecutive days. In histomorphological studies, cochlear hydrops degree was evaluated by hematoxylin-eosin (HE) staining, and then the ratio of scala media (SM) area to SM + scala vestibuli (SV) area (R value) was calculated...
January 15, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29315188/relationship-between-the-extent-of-endolymphatic-hydrops-and-the-severity-and-fluctuation-of-audiovestibular-symptoms-in-patients-with-meni%C3%A3-re-s-disease-and-mri-evidence-of-hydrops
#19
Claudia Jerin, Sonja Floerke, Rebecca Maxwell, Robert Gürkov
OBJECTIVE: To characterize the short-, middle-, and long-term occurrence of vertigo attacks in a large population of Menière's disease (MD) and to investigate the relationship between the extent of endolymphatic hydrops (ELH) and the severity of audiovestibular symptoms. STUDY DESIGN: Prospective observational study. METHODS: One hundred ninety-two patients with clinically definite MD participated in this study. The degree of ELH was visualized by locally enhanced inner ear magnetic resonance imaging...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29299506/longitudinal-up-regulation-of-endolymphatic-hydrops-in-patients-with-meniere-s-disease-during-medical-treatment
#20
Munehisa Fukushima, Tadashi Kitahara, Ryohei Oya, Shiro Akahani, Hidenori Inohara, Shinji Naganawa, Noriaki Takeda
Objective/Hypothesis: Meniere's disease (MD) is a common inner ear disease characterized by repeated episodic vertigo, fluctuating sensorineural hearing loss, and tinnitus. Its pathology is defined as endolymphatic hydrops (EH) in the inner ear and EH has been hypothesized to correlate with the clinical symptoms of MD. We presented the dynamics of in vivo EH in MD patients during medical treatments. Study Design: Prospective, single-arm repeated measures. Methods: Eleven MD patients were enrolled...
December 2017: Laryngoscope Investigative Otolaryngology
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