keyword
https://read.qxmd.com/read/34693601/crosstalk-between-h-2-s-and-no-an-emerging-signalling-pathway-during-waterlogging-stress-in-legume-crops
#21
REVIEW
A Tyagi, S Sharma, S Ali, K Gaikwad
In legumes, waterlogging is a major detrimental factor leading to huge yield losses. Generally, legumes lack tolerance to submergence, and conventional breeding to develop tolerant varieties are limited due to the lack of tolerant germplasm and potential target genes. Moreover, our understanding of the various signalling cascades, their interactions and key pathways induced during waterlogging is limited. Here, we focus on the role of two important plant signalling molecules, viz. hydrogen sulphide (H2 S) and nitric oxide (NO), during waterlogging stress in legumes...
October 24, 2021: Plant Biology
https://read.qxmd.com/read/34080216/circulating-levels-of-hydrogen-sulphide-negatively-correlate-to-nitrite-levels-in-gestational-hypertensive-and-preeclamptic-pregnant-women
#22
JOURNAL ARTICLE
Jose Sergio Possomato-Vieira, Ana Carolina Palei, Caroline Cristina Pinto-Souza, Ricardo Cavalli, Carlos Alan Dias-Junior, Valeria Sandrim
Endothelial dysfunction is a hallmark of preeclampsia and the role of nitric oxide (NO) has been extensively studied in this pregnancy complication. In recent years, hydrogen sulphide (H2 S) has arisen as a new gasotransmitter with impact on endothelial function. However, the involvement of H2 S in the pathophysiology of preeclampsia is not fully comprehended, and only few studies with limited sample size have investigated circulating levels of H2 S in preeclamptic patients. Moreover, H2 S levels have not been previously evaluated in gestational hypertension...
June 3, 2021: Clinical and Experimental Pharmacology & Physiology
https://read.qxmd.com/read/33974111/nitric-oxide-crosstalk-with-stress-regulators-and-plant-abiotic-stress-tolerance
#23
REVIEW
Xianrong Zhou, Shrushti Joshi, Tushar Khare, Suraj Patil, Jin Shang, Vinay Kumar
Nitric oxide is a dynamic gaseous molecule involved in signalling, crosstalk with stress regulators, and plant abiotic-stress responses. It has great exploratory potentials for engineering abiotic stress tolerance in crops. Nitric oxide (NO), a redox-active gaseous signalling molecule, though present uniformly through the eukaryotes, maintain its specificity in plants with respect to its formation, signalling, and functions. Its cellular concentrations are decisive for its function, as a signalling molecule at lower concentrations, but triggers nitro-oxidative stress and cellular damage when produced at higher concentrations...
May 11, 2021: Plant Cell Reports
https://read.qxmd.com/read/33665834/emerging-warriors-against-salinity-in-plants-nitric-oxide-and-hydrogen-sulphide
#24
JOURNAL ARTICLE
Vinod Goyal, Dharmendra Jhanghel, Shweta Mehrotra
Agriculture sector is vulnerable to various environmental stresses which significantly mitigate plant growth, performance and development. Abiotic stresses such as salinity and drought cause severe losses in crop productivity worldwide. Soil salinity is a major stress which suppresses plant development through osmotic stress accompanied by ion toxicity, nutritional imbalance, and oxidative stress. Various defense mechanisms like osmolytes accumulations, activation of stress-induced genes and transcription factors, production of plant growth hormones, accumulation of anti-oxidants and redox defense system in plants are responsible for combating salt stress...
March 4, 2021: Physiologia Plantarum
https://read.qxmd.com/read/33486763/impairment-of-platelet-nitric-oxide-signaling-in-coronary-artery-spasm-role-of-hydrogen-sulphide
#25
JOURNAL ARTICLE
Hasan Imam, Thanh H Nguyen, Irene Stafford, Saifei Liu, Tamila Heresztyn, Yuliy Y Chirkov, John D Horowitz
BACKGROUND AND PURPOSE: The pathophysiology of coronary artery spasm (CAS), with its associated ischaemic crises, is currently poorly understood, and treatment is frequently ineffective. In view of increasing evidence that platelet-based defects may occur in CAS patients, we investigated platelet reactivity in CAS patients and whether symptomatic crises reflect activation of platelet-endothelial interactions. EXPERIMENTAL APPROACH: CAS patients were evaluated during acute and/or chronic symptomatic phases, and compared with healthy control subjects...
January 24, 2021: British Journal of Pharmacology
https://read.qxmd.com/read/33318876/targeting-hydrogen-sulphide-signaling-in-breast-cancer
#26
REVIEW
Rana Ahmed Youness, Ahmed Zakaria Gad, Khaled Sanber, Yong Jin Ahn, Gi-Ja Lee, Emad Khallaf, Hafez Mohamed Hafez, Amira Abdel Motaal, Nabil Ahmed, Mohamed Zakaria Gad
INTRODUCTION: Hydrogen sulphide (H2 S) has been established as a key member of the gasotransmitters family that recently showed a pivotal role in various pathological conditions including cancer. OBJECTIVES: This study investigated the role of H2 S in breast cancer (BC) pathogenesis, on BC immune recognition capacity and the consequence of targeting H2 S using non-coding RNAs. METHODS: Eighty BC patients have been recruited for the study. BC cell lines were cultured and transfected using validated oligonucleotide delivery system...
January 2021: Journal of Advanced Research
https://read.qxmd.com/read/33246971/h-2-s-promotes-developmental-brain-angiogenesis-via-the-nos-no-pathway-in-zebrafish
#27
JOURNAL ARTICLE
Weiqing Jiang, Chen Liu, Mingzhu Deng, Fei Wang, Xiao Ren, Yilin Fan, Jiulin Du, Yonggang Wang
BACKGROUND: Hydrogen sulphide (H2 S) is considered as the third member of the gasotransmitter family, along with nitric oxide (NO) and carbon monoxide. H2 S has been reported to induce angiogenesis by promoting the growth, migration and tube-like structure formation of endothelial cells. Those studies were conducted in conditions of cell culture, mouse Matrigel plug assay model, rat wound healing model or rat hindlimb ischaemia model. Recent in vivo studies showed the physiological importance of H2 S in muscle angiogenesis...
November 27, 2020: Stroke and Vascular Neurology
https://read.qxmd.com/read/32871779/hydrogen-sulphide-and-nitric-oxide-cooperate-in-cardioprotection-against-ischemia-reperfusion-injury-in-isolated-rat-heart
#28
JOURNAL ARTICLE
Savas Ustunova, Selcuk Takir, Nadim Yilmazer, Huri Bulut, Didem Altindirek, Ozden Hatirnaz Ng, Cihan Demirci Tansel, B Sonmez Uydes Dogan, Ugur Ozbek, Elif Ilkay Armutak, Ebru Gurel Gurevin
BACKGROUND/AIM: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H2 S) and nitric oxide (NO) in ischemia/reperfusion (I/R) injury. MATERIALS AND METHODS: Rat hearts were studied with the Langendorff technique using the H2 S donor sodium hydrosulfide (NaHS, 40 μM) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation...
September 2020: In Vivo
https://read.qxmd.com/read/32383522/the-role-of-mitochondrial-reactive-oxygen-species-no-and-h-2-s-in-ischaemia-reperfusion-injury-and-cardioprotection
#29
REVIEW
Ioanna Andreadou, Rainer Schulz, Andreas Papapetropoulos, Belma Turan, Kirsti Ytrehus, Peter Ferdinandy, Andreas Daiber, Fabio Di Lisa
Redox signalling in mitochondria plays an important role in myocardial ischaemia/reperfusion (I/R) injury and in cardioprotection. Reactive oxygen and nitrogen species (ROS/RNS) modify cellular structures and functions by means of covalent changes in proteins including among others S-nitros(yl)ation by nitric oxide (NO) and its derivatives, and S-sulphydration by hydrogen sulphide (H2 S). Many enzymes are involved in the mitochondrial formation and handling of ROS, NO and H2 S under physiological and pathological conditions...
June 2020: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/32068124/effect-of-gasotransmitters-treatment-on-expression-of-hypertension-vascular-and-cardiac-remodeling-and-hypertensive-nephropathy-genes-in-left-ventricular-hypertrophy
#30
JOURNAL ARTICLE
Ashfaq Ahmad, Zainab Riaz, Munavvar Abdul Sattar, Safia Akhtar Khan, Edward James John, Sumbal Arshad, Syed Tahir Abbas Shah, Muhammad Arshad Rafiq, Maleeha Azam, Raheel Qamar
BACKGROUND: Cardiac and renal dysfunction are often co-morbid pathologies leading to worsening prognosis resulting in difficulty in therapy of left ventricular hypertrophy (LVH). The aim of the current study was to determine the changes in expression of human ortholog genes of hypertension, vascular and cardiac remodeling and hypertensive nephropathy phenotypes under normal, disease and upon treatment with gasotransmitter including H2 S (hydrogen sulphide), NO (nitric oxide) and combined (H2 S+NO)...
February 14, 2020: Gene
https://read.qxmd.com/read/31479515/regulation-of-physiological-aspects-in-plants-by-hydrogen-sulfide-and-nitric-oxide-under-challenging-environment
#31
JOURNAL ARTICLE
Saikat Paul, Aryadeep Roychoudhury
Plants are exposed to a plethora of abiotic stresses like drought, salinity, heavy metal and temperature stresses at different stages of their life cycle, from germination to seedling till reproductive phase. As protective mechanisms, plants release signalling molecules that initiate a cascade of stress-signalling events, leading either to programmed cell death or plant acclimation. Hydrogen sulphide (H2 S) and nitric oxide (NO) are considered as new 'gasotransmitter' molecules which play key roles in regulating gene expression, post-translational modification, as well as cross-talk with other hormones...
September 3, 2019: Physiologia Plantarum
https://read.qxmd.com/read/31406919/causation-of-human-ulcerative-colitis-a-lead-from-an-animal-model-that-mirrors-human-disease
#32
JOURNAL ARTICLE
William E W Roediger
Most models of experimental colitis do not replicate human ulcerative colitis and do not help in defining the causation of human ulcerative colitis. Inducing pantothenic acid deficiency in pigs produces an ideal model in terms of extent, histology, and chronicity of human ulcerative colitis. Comparing metabolic changes in human ulcerative colitis with metabolic changes in experimental colitis in pigs provided a guide for the search of initiating factors of human ulcerative colitis. Observations showed that bacterial nitric oxide with bacterial hydrogen sulphide reproduced the metabolic changes of human ulcerative colitis...
August 2019: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
https://read.qxmd.com/read/31350249/pharmacological-interventions-for-the-prevention-of-fetal-growth-restriction-protocol-for-a-systematic-review-and-network-meta-analysis
#33
JOURNAL ARTICLE
Alessandra Bettiol, Niccolò Lombardi, Giada Crescioli, Laura Avagliano, Alessandro Mugelli, Claudia Ravaldi, Alfredo Vannacci
INTRODUCTION: Fetal growth restriction (FGR) includes different conditions in which a fetus fails to reach the own full growth, and accounts for 28%-45% of non-anomalous stillbirths. The management of FGR is based on the prolongation of pregnancy long enough for fetal organs to mature while preventing starvation. As for pharmacological management, most guidelines recommend treatment with low-dose aspirin and/or with heparin, although this approach is still controversial and innovative promising therapies are under investigation...
July 26, 2019: BMJ Open
https://read.qxmd.com/read/31249256/recent-advances-in-the-neuroprotective-effects-of-medical-gases
#34
REVIEW
Yue-Zhen Wang, Ting-Ting Li, Hong-Ling Cao, Wan-Chao Yang
Central nervous system injuries are a leading cause of death and disability worldwide. Although the exact pathophysiological mechanisms of various brain injuries vary, central nervous system injuries often result in an inflammatory response, and subsequently lead to brain damage. This suggests that neuroprotection may be necessany in the treatment of multiple disease models. The use of medical gases as neuroprotective agents has gained great attention in the medical field. Medical gases include common gases, such as oxygen, hydrogen and carbon dioxide; hydrogen sulphide and nitric oxide that have been considered toxic; volatile anesthetic gases, such as isoflurane and sevoflurane; and inert gases like helium, argon, and xenon...
April 2019: Medical Gas Research
https://read.qxmd.com/read/31113654/gaseous-transmitters-in-human-retinogenesis
#35
JOURNAL ARTICLE
Sergei G Kalinichenko, Natalya Yu Matveeva, Igor I Pushchin
Endogenous gaseous transmitters (nitric oxide, carbon monoxide, and hydrogen sulphide) form a special neuromodulation system mediating the development and modification of nerve centers. Here, we examined the localization of key gaseous transmitter enzymes: cystathionine β-synthetase (CBS), cystathionine γ-lyase (CSE), heme oxygenase 2 (HO-2), and constitutive NO synthase (nNOS) in the fetal human retina at different stages of development. The number of CBS- and CSE-positive photoreceptors and intermediate retinal neurons was high in trimester I and gradually decreased to the end of trimester III...
May 18, 2019: Acta Histochemica
https://read.qxmd.com/read/30980533/integrative-roles-of-nitric-oxide-and-hydrogen-sulfide-in-melatonin-induced-tolerance-of-pepper-capsicum-annuum-l-plants-to-iron-deficiency-and-salt-stress-alone-or-in-combination
#36
JOURNAL ARTICLE
Cengiz Kaya, David Higgs, Muhammad Ashraf, Mohammed Nasser Alyemeni, Parvaiz Ahmad
There seems to be no report in the literature on the effect of melatonin (MT) in relieving the detrimental effects of combined application of salt stress (SS) and iron deficiency (ID). Furthermore, the effect of MT on the accumulation/synthesis of endogenous nitric oxide (NO) and hydrogen sulphide (H2 S) and how far these molecules are involved in MT-improved tolerance to the combined application of ID and SS in pepper (Capsicum annuum L) were tested. Hence, two individual trials were set up. The treatments in the first experiment comprised: Control, ID (0...
April 13, 2019: Physiologia Plantarum
https://read.qxmd.com/read/30706510/effects-of-hydrogen-sulphide-donor-sodium-hydrosulphide-treatment-on-the-erectile-dysfunction-in-l-name-induced-hypertensive-rats
#37
JOURNAL ARTICLE
Enis Yilmaz, Ecem Kaya-Sezginer, Didem Yilmaz-Oral, Tugba Cengiz, Nur Bayatli, Serap Gur
Men with hypertension often develop erectile dysfunction (ED). The present study aimed to examine the effects of sodium hydrosulphide (NaHS), a hydrogen (H2 S) donor, treatment on ED in nitric oxide synthase (NOS) inhibitor (L-NAME)-induced hypertensive rats. Forty adult Sprague-Dawley rats were divided into four groups: control, NaHS (0.037 mg kg day-1 )-treated control, L-NAME-induced hypertension (40 mg kg day-1 ) and NaHS-treated L-NAME-induced hypertension. The ratio of intracavernosal pressure to mean arterial pressure and isometric tension of corpus cavernosum (CC) were measured...
January 31, 2019: Andrologia
https://read.qxmd.com/read/30689461/lps-induced-apoptosis-is-partially-mediated-by-hydrogen-sulphide-in-raw-264-7-murine-macrophages
#38
JOURNAL ARTICLE
Leema George, Tamizhselvi Ramasamy, Kns Sirajudeen, Venkatraman Manickam
Lipopolysaccharide (LPS) induces apoptosis in murine macrophages through the autocrine secretion of tumor necrosis factor (TNF)-α and nitric oxide (NO). LPS-induced inflammation in murine macrophages is associated with hydrogen sulfide (H2 S) production. In this present study, we reported the novel role of H2 S in LPS-induced apoptosis and its underlying molecular mechanism specifically at late phases in murine macrophage cells. Stimulation of RAW 264.7 macrophages with LPS resulted in a time- and dose-dependent induction of apoptosis...
January 28, 2019: Immunological Investigations
https://read.qxmd.com/read/30596400/functional-protection-against-cardiac-diseases-depends-on-atp-sensitive-potassium-channels
#39
REVIEW
Peng Ye, Yan-Rong Zhu, Yue Gu, Dai-Min Zhang, Shao-Liang Chen
ATP-sensitive potassium channels (KATP ) channels are widely distributed in various tissues, including pancreatic beta cells, muscle tissue and brain tissue. KATP channels play an important role in cardioprotection in physiological/pathological situations. KATP channels are inhibited by an increase in the intracellular ATP concentration and are stimulated by an increase in the intracellular MgADP concentration. Activation of KATP channels decreases ischaemia/reperfusion injury, protects cardiomyocytes from heart failure, and reduces the occurrence of arrhythmias...
December 2018: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/30403161/metabolic-resuscitation-strategies-to-prevent-organ-dysfunction-in-sepsis
#40
REVIEW
Vera A Reitsema, Bastiaan S Star, Vincent D de Jager, Matijs van Meurs, Robert H Henning, Hjalmar R Bouma
Significance: Sepsis is the main cause of death among patients admitted to the intensive care unit. As current treatment is limited to antimicrobial therapy and supportive care, mortality remains high, which warrants efforts to find novel therapies. Recent Advances: Mitochondrial dysfunction is emerging as a key process in the induction of organ dysfunction during sepsis, and metabolic resuscitation might reveal to be a novel cornerstone in the treatment of sepsis. Critical Issues: Here, we review novel strategies to maintain organ function in sepsis by precluding mitochondrial dysfunction by lowering energetic demand to allow preservation of adenosine triphosphate-levels, while reducing free radical generation...
July 10, 2019: Antioxidants & Redox Signaling
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