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Hydrogen sulphide and nitric oxide

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https://www.readbyqxmd.com/read/28512525/h2s-donor-nahs-changes-the-production-of-endogenous-h2s-and-no-in-d-galactose-induced-accelerated-ageing
#1
Wei Wu, Cui-Lan Hou, Xue-Pan Mu, Chen Sun, Yi-Chun Zhu, Ming-Jie Wang, Qian-Zhou Lv
Aims. The study was designed to explore whether hydrogen sulphide (H2S) and nitric oxide (NO) generation changed in D-galactose- (D-gal-) induced ageing, the possible effects of exogenous H2S supplementation, and related mechanisms. Results. In D-gal-induced senescent mice, both H2S and NO levels in the heart, liver, and kidney tissues were decreased significantly. A similar trend was observed in D-gal-challenged human umbilical vein endothelial cells (HUVECs). Sustained H2S donor (NaHS) treatment for 2 months elevated H2S and NO levels in these mice, and during this period, the D-gal-induced senescent phenotype was reversed...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28467198/chronic-nahs-treatment-decreases-oxidative-stress-and-improves-endothelial-function-in-diabetic-mice
#2
Hooi H Ng, Gunes S Yildiz, Jacqueline M Ku, Alyson A Miller, Owen L Woodman, Joanne L Hart
Hydrogen sulphide (H2S) is endogenously produced in vascular tissue and has anti-oxidant and vasoprotective properties. This study investigates whether chronic treatment using the fast H2S donor NaHS could elicit a vasoprotective effect in diabetes. Diabetes was induced in male C57BL6/J mice with streptozotocin (60 mg/kg daily, ip for 2 weeks) and confirmed by elevated blood glucose and glycated haemoglobin levels. Diabetic mice were then treated with NaHS (100 µmol/kg/day) for 4 weeks, and aortae collected for functional and biochemical analyses...
May 2017: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/28433660/redox-regulation-of-gasotransmission-in-the-vascular-system-a-focus-on-angiogenesis
#3
REVIEW
Rajesh K Mistry, Alison C Brewer
Reactive oxygen species have emerged as key participants in a broad range of physiological and pathophysiological processes, not least within the vascular system. Diverse cellular functions which have been attributed to some of these pro-oxidants within the vasculature include the regulation of blood pressure, neovascularisation and vascular inflammation. We here highlight the emerging roles of the enzymatically-generated reaction oxygen species, O2(-) and H2O2, in the regulation of the functions of the gaseous signalling molecules: nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H2S)...
April 19, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28251989/silver-nanoparticles-reduce-brain-inflammation-and-related-neurotoxicity-through-induction-of-h2s-synthesizing-enzymes
#4
Daniel A Gonzalez-Carter, Bey Fen Leo, Pakatip Ruenraroengsak, Shu Chen, Angela E Goode, Ioannis G Theodorou, Kian Fan Chung, Raffaella Carzaniga, Milo S P Shaffer, David T Dexter, Mary P Ryan, Alexandra E Porter
Silver nanoparticles (AgNP) are known to penetrate into the brain and cause neuronal death. However, there is a paucity in studies examining the effect of AgNP on the resident immune cells of the brain, microglia. Given microglia are implicated in neurodegenerative disorders such as Parkinson's disease (PD), it is important to examine how AgNPs affect microglial inflammation to fully assess AgNP neurotoxicity. In addition, understanding AgNP processing by microglia will allow better prediction of their long term bioreactivity...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28150299/role-of-pvat-in-coronary-atherosclerosis-and-vein-graft-patency-friend-or-foe
#5
REVIEW
M S Fernández-Alfonso, M Gil-Ortega, I Aranguez, D Souza, M Dreifaldt, B Somoza, M R Dashwood
Perivascular adipose tissue (PVAT) releases numerous factors and adipokines with paracrine effects on both vascular structure and function. These effects are variable as they depend on regional differences in PVAT among blood vessels and vary with changes in adiposity. There is considerable evidence demonstrating an association between coronary PVAT and the development and progression of coronary artery disease, which is associated with inflammation, oxidative stress, angiogenesis, vascular remodelling and blood clotting...
February 1, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/27983540/plasma-nitric-oxide-level-is-correlated-with-microvascular-functions-in-the-peripheral-arterial-disease
#6
Muzaffer Akkoca, Suzan Emel Usanmaz, Cuneyt Koksoy, Ugur Bengisun, Emine Demirel-Yilmaz
At present there is no widely accepted biomarker for monitoring of vascular functions. The purpose of this prospective study was to investigate the association of some blood biomarkers with vascular reactivity in patients with peripheral arterial diseases (PAD). A prospective evaluation was made of 3 groups comprising a control group of healthy individuals, and patients with PAD caused by either atherosclerosis or Buerger's disease. Microvascular perfusion was examined using laser Doppler imaging of cutaneous erythrocyte flux after iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP)...
2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27779471/the-adaptive-role-of-nitric-oxide-and-hydrogen-sulphide-in-vasoactive-responses-of-thoracic-aorta-is-triggered-already-in-young-spontaneously-hypertensive-rats
#7
S Cacanyiova, A Berenyiova, F Kristek, M Drobna, K Ondrias, M Grman
The aorta plays an important role in blood pressure control so the early determination of its vasoactive properties could predict pathological changes in hypertension. The aim of study was to compare vasoactive properties and geometry of thoracic aorta (TA) and the participation of two vasoactive transmitters, nitric oxide (NO) and hydrogen sulphide (H2S), in TA tone regulation in young Wistar rats (WR) and spontaneously hypertensive rats (SHR). Four-weeks-old WR and SHR were used. Systolic blood pressure (sBP) was measured by plethysmography...
August 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27775418/cardiovascular-effects-of-gasotransmitter-donors
#8
REVIEW
M Cebová, M Košútová, O Pecháňová
Gasotransmitters represent a subfamily of the endogenous gaseous signaling molecules that include nitric oxide (NO), carbon monoxide (CO), and hydrogen sulphide (H(2)S). These particular gases share many common features in their production and function, but they fulfill their physiological tasks in unique ways that differ from those of classical signaling molecules found in tissues and organs. These gasotransmitters may antagonize or potentiate each other's cellular effects at the level of their production, their downstream molecular targets and their direct interactions...
October 24, 2016: Physiological Research
https://www.readbyqxmd.com/read/27775417/the-role-of-hydrogen-sulphide-in-blood-pressure-regulation
#9
REVIEW
S Cacanyiova, A Berenyiova, F Kristek
Cardiovascular studies have confirmed that hydrogen sulphide (H(2)S) is involved in various signaling pathways in both physiological and pathological conditions, including hypertension. In contrast to nitric oxide (NO), which has a clear vasorelaxant action, H(2)S has both vasorelaxing and vasoconstricting effects on the cardiovascular system. H(2)S is an important antihypertensive agent, and the reduced production of H(2)S and the alterations in its functions are involved in the initiation of spontaneous hypertension...
October 24, 2016: Physiological Research
https://www.readbyqxmd.com/read/27271248/left-ventricular-function-during-porcine-resuscitated-septic-shock-with-pre-existing-atherosclerosis
#10
Benedikt L Nußbaum, Oscar McCook, Clair Hartmann, José Matallo, Martin Wepler, Elena Antonucci, Miriam Kalbitz, Markus Huber-Lang, Michael Georgieff, Enrico Calzia, Peter Radermacher, Sebastian Hafner
BACKGROUND: Reversible, depressed cardiac function is frequently encountered during septic shock and commonly called septic cardiomyopathy. Previous studies demonstrated reduced ejection fraction and left ventricular dilatation in both humans and animal models. However, the majority of the studies in humans excluded pre-existing cardiac disease and animal studies were performed on healthy specimen and/or without vasopressor support during sepsis. In order to more closely mimic the actual patients' conditions on intensive care units and to assess the influence of both cardiac comorbidity and vasopressor support on septic cardiomyopathy, we evaluated the left ventricular function in a porcine model of resuscitated septic shock with pre-existing atherosclerosis...
December 2016: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27191852/cystathione-gamma-lyase-hydrogen-sulphide-pathway-up-regulation-enhances-the-responsiveness-of-%C3%AE-1a-and-%C3%AE-1b-adrenoreceptors-in-the-kidney-of-rats-with-left-ventricular-hypertrophy
#11
Ashfaq Ahmad, Munavvar A Sattar, Maleeha Azam, Mohammed H Abdulla, Safia A Khan, Fayyaz Hashmi, Nor A Abdullah, Edward J Johns
The purpose of the present study was to investigate the interaction between H2S and NO (nitric oxide) in the kidney and to evaluate its impact on the functional contribution of α1A and α1B-adrenoreceptors subtypes mediating the renal vasoconstriction in the kidney of rats with left ventricular hypertrophy (LVH). In rats the LVH induction was by isoprenaline administration and caffeine in the drinking water together with intraperitoneal administration of H2S. The responsiveness of α1A and α1B to exogenous noradrenaline, phenylephrine and methoxaminein the absence and presence of 5-methylurapidil (5-MeU) and chloroethylclonidine (CEC) was studied...
2016: PloS One
https://www.readbyqxmd.com/read/26906467/the-function-of-hydrogen-sulphide-in-iron-availability-sulfur-nutrient-or-signaling-molecule
#12
Juan Chen, Zhou-Ping Shangguan, Hai-Lei Zheng
Hydrogen sulphide (H2S) has traditionally been considered as a phytotoxin, having deleterious effects on the plant growth and survival. Recently, it was recongnized as a potential signaling molecule involving in physiological regulation similar to nitric oxide (NO) and carbon monoxide (CO) in plants. In a recent study, we mainly focused on the signaling function of H2S in improving adaptation of Zea mays seedlings to iron deficiency. We reported that H2S was closely related to iron uptake, transport, and accumulation, and consequently increased chlorophyll biosynthesis, chloroplast development, and photosynthesis in Z...
June 2, 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/26683634/a-nanoengineered-conductometric-device-for-accurate-analysis-of-elemental-mercury-vapor
#13
Matthew J Griffin, K M Mohibul Kabir, Victoria E Coyle, Ahmad Esmaielzadeh Kandjani, Ylias M Sabri, Samuel J Ippolito, Suresh K Bhargava
We developed a novel conductometric device with nanostructured gold (Au) sensitive layer which showed high-performance for elemental mercury (Hg(0)) vapor detection under simulated conditions that resemble harsh industrial environments. That is, the Hg(0) vapor sensing performance of the developed sensor was investigated under different operating temperatures (30-130 °C) and working conditions (i.e., humid) as well as in the presence of various interfering gas species, including ammonia (NH3), hydrogen sulfide (H2S), nitric oxide (NO), carbon mono-oxide (CO), carbon dioxide (CO2), sulfur dioxide (SO2), hydrogen (H2), methane (CH4), and volatile organic compounds (VOCs) such as ethylmercaptan (EM), acetaldehyde (MeCHO) and methyl ethyl ketone (MEK) among others...
February 2, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/26660653/an-emerging-role-for-gasotransmitters-in-the-control-of-breathing-and-ionic-regulation-in-fish
#14
REVIEW
Steve Perry, Y Kumai, C S Porteus, V Tzaneva, R W M Kwong
Three gases comprising nitric oxide, carbon monoxide and hydrogen sulphide, collectively are termed gasotransmitters. The gasotransmitters control several physiological functions in fish by acting as intracellular signaling molecules. Hydrogen sulphide, first implicated in vasomotor control in fish, plays a critical role in oxygen chemoreception owing to its production and downstream effects within the oxygen chemosensory cells, the neuroepithelial cells. Indeed, there is emerging evidence that hydrogen sulphide may contribute to oxygen sensing in both fish and mammals by promoting membrane depolarization of the chemosensory cells...
February 2016: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/26486177/three-gaseous-neurotransmitters-nitric-oxide-carbon-monoxide-and-hydrogen-sulfide-are-involved-in-the-neurogenic-relaxation-responses-of-the-porcine-internal-anal-sphincter
#15
Oladayo Folasire, Kylie A Mills, Donna J Sellers, Russ Chess-Williams
BACKGROUND/AIMS: The internal anal sphincter (IAS) plays an important role in maintaining continence and a number of neurotransmitters are known to regulate IAS tone. The aim of this study was to determine the relative importance of the neurotransmitters involved in the relaxant and contractile responses of the porcine IAS. METHODS: Responses of isolated strips of IAS to electrical field stimulation (EFS) were obtained in the absence and presence of inhibitors of neurotransmitter systems...
January 31, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/26130330/the-sensing-of-respiratory-gases-in-fish-mechanisms-and-signalling-pathways
#16
REVIEW
S F Perry, V Tzaneva
Chemoreception in fish is critical for sensing changes in the chemical composition of the external and internal environments and is often the first step in a cascade of events leading to cardiorespiratory and metabolic adjustments. Of paramount importance is the ability to sense changes in the levels of the three respiratory gases, oxygen (O2), carbon dioxide (CO2) and ammonia (NH3). In this review, we discuss the role of piscine neuroepithelial cells (NEC), putative peripheral chemoreceptors, as tri-modal sensors of O2, CO2 and NH3...
April 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/25807236/interactions-of-the-gasotransmitters-contribute-to-microvascular-tone-dys-regulation-in-the-preterm-neonate
#17
Rebecca M Dyson, Hannah K Palliser, Joanna L Latter, Megan A Kelly, Grazyna Chwatko, Rafal Glowacki, Ian M R Wright
BACKGROUND & AIMS: Hydrogen sulphide (H2S), nitric oxide (NO), and carbon monoxide (CO) are involved in transitional microvascular tone dysregulation in the preterm infant; however there is conflicting evidence on the interaction of these gasotransmitters, and their overall contribution to the microcirculation in newborns is not known. The aim of this study was to measure the levels of all 3 gasotransmitters, characterise their interrelationships and elucidate their combined effects on microvascular blood flow...
2015: PloS One
https://www.readbyqxmd.com/read/25789644/-pharmacotherapy-and-analysis-of-gaseous-mediators-in-hypertensive-patients
#18
Letícia Palota Eid, Renato Nery Soriano, Marcelo Eduardo Batalhão, Lais Palotta Balderrama, Evelin Capellari Carnio
OBJECTIVE: To evaluate the effect of using antihypertensive classes of drugs of the calcium channel antagonists and inhibitors of angiotensin-converting enzyme in plasma concentrations of hydrogen sulfide and nitric oxide in patients with hypertension. METHODS: Cross-sectional study with quantitative approach conducted with hypertensive patients in use of antihypertensive classes of drugs: angiotensin-converting enzyme inhibitors or calcium channel antagonists. RESULTS: It was found that the concentration of plasma nitric oxide was significantly higher in hypertensive patients that were in use of angiotensin-converting enzyme inhibitors (p<0...
February 2015: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/25751010/endogenous-cardioprotective-agents-role-in-pre-and-postconditioning
#19
REVIEW
Claudia Penna, Riccarda Granata, Carlo Gabriele Tocchetti, Maria Pia Gallo, Giuseppe Alloatti, Pasquale Pagliaro
Cardiovascular diseases (CVD) are the leading cause of death, chronic illness and disability in Western countries. The most common cause of CVD derives from the harmful effects of acute myocardial ischemia and subsequent reperfusion injury. Cardioprotection against acute ischemia/ reperfusion injury is made possible by the "conditioning protocols." Conditioning is obtained by applying a few periods of brief ischemia and reperfusion in the event of prolonged (index) ischemia that may cause myocardial infarction...
2015: Current Drug Targets
https://www.readbyqxmd.com/read/25711469/hydrogen-sulphide-induces-vasoconstriction-of-rat-coronary-artery-via-activation-of-ca-2-influx
#20
N-N Ping, S Li, Y-N Mi, L Cao, Y-X Cao
AIM: Hydrogen sulphide (H2S) exhibits a dual modulation of isolated artery tension. This study investigated the vasoconstrictive effect of sulphur sodium hydride (NaHS), a donor of gaseous H2S, on rat coronary artery. METHODS: The contractile response of isolated arteries was recorded using a wire myograph. Fluo-3/AM was used to load vascular smooth muscle, and intracellular calcium was determined using confocal laser microscopy. The protein expression of Rho kinase was examined using Western blot...
May 2015: Acta Physiologica
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