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Hydrogen sulphide and corpus cavernosum

Nilima Shukla, Giuseppe Rossoni, Matthew Hotston, Anna Sparatore, Piero Del Soldato, Valerio Tazzari, Raj Persad, Gianni D Angelini, Jamie Y Jeremy
OBJECTIVE To study the effect of the H(2)S-donating derivative of sildenafil (ACS6) compared to sildenafil citrate and sodium hydrosulphide (NaHS) on relaxation, superoxide formation and NADPH oxidase and type 5 phosphodiesterase (PDE5) expression in isolated rabbit cavernosal tissue and smooth muscle cells (CSMCs), and in vivo on indices of oxidative stress induced with buthionine sulphoximine (BSO). MATERIALS AND METHODS Relaxation was studied in an organ bath in response to carbachol and after incubation with interleukin-1beta for 12 h...
June 2009: BJU International
Balasubramanian Srilatha, P Ganesan Adaikan, Ling Li, Philip K Moore
INTRODUCTION: In a pilot study, we found that the novel gasotransmitter, hydrogen sulfide (H2S), had a vasodilatory and proerectile action on the cavernosum. In the present work, we explored the ability of the cavernosum to synthesize H2S and its mechanism on the cavernosal pathways. AIM: To evaluate the physiopharmacological responses and mechanism in the erectile function of H2S in rabbit cavernosum. METHODS: Rabbit corpus cavernosum (CC) smooth muscle tissue (N = 5) was homogenized and incubated with L-cysteine (10 mM) and pyridoxal 5'-phosphate (2 mM) to detect H2S formation...
September 2007: Journal of Sexual Medicine
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