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https://www.readbyqxmd.com/read/29055276/nonadiabatic-dynamics-simulation-of-photoisomerization-mechanism-of-the-second-stablest-isomer-of-n-salicilydenemethylfurylamine
#1
Aihua Gao, Jianpeng Li, Dehua Wang, Xiaoguang Ma, Meishan Wang
The photoisomerization processes of the second stablest isomer in the aromatic Schiff base, N-salicilydenemethylfurylamine, in the gas phase have been studied by static electronic structure calculations and surface-hopping dynamics simulations based on the Zhu-Nakamura theory. Various stable structures are obtained in the optimization because of different orientations of methyl-furyl part with respect to the salicylaldimine part and different orientations of hydroxy group with respect to the benzene ring. Upon photoexcitation into the first excited state, bond isomerization in the salicylaldimine part is completely suppressed until the strong excited-state hydrogen bond is broken...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055194/a-graphene-quantum-dots-based-electrochemiluminescence-immunosensor-for-carcinoembryonic-antigen-detection-using-poly-5-formylindole-reduced-graphene-oxide-nanocomposite
#2
Guangming Nie, Yang Wang, Yun Tang, Dan Zhao, Qingfu Guo
A novel electrochemiluminescence (ECL) immunosensor for ultrasensitive detection of carcinoembryonic antigen (CEA) was developed using signal amplification strategy based on poly(5-formylindole)/reduced graphene oxide nanocomposite (P5FIn/erGO) and Au nanoparticle (AuNP) decorated graphene quantum dots (GQDs) (GQDs@AuNP). As an effective matrix for immobilization of primary antibody (Ab1), P5FIn/erGO nanocomposite facilitated the ion transport during the redox reactions and provided larger surface areas for the immobilization of Ab1...
October 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29055186/designed-inhibitors-with-hetero-linkers-for-gastric-proton-pump-h-k-atpase-steered-molecular-dynamics-and-metadynamics-studies
#3
Kalyanashis Jana, Tusar Bandyopadhyay, Bishwajit Ganguly
Acid suppressant SCH28080 and its derivatives reversibly reduce acid secretion activity of the H(+),K(+)-ATPase in a K(+) competitive manner. The results on homologation of the SCH28080 by varying the linker chain length suggested the improvement in efficacy. However, the pharmacokinetic studies reveal that the hydrophobic nature of the CH2 linker units may not help it to function as a better acid suppressant. We have exploited the role of linker unit to enhance the efficacy of such reversible acid suppressant drug molecules using hetero linker, i...
October 12, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29055169/diversification-in-tropics-and-subtropics-following-the-mid-miocene-climate-change-a-case-study-of-the-spider-genus-nesticella
#4
Francesco Ballarin, Shuqiang Li
Caves may offer suitable refugia for troglophilic invertebrates during periods of unfavourable climatic conditions because of their stable microclimates. As a consequence, allopatric divergence from their epigean counterparts may occur, leading to formation of truly hypogean communities (the Climatic Relict Hypothesis). Unlike the well-studied effects of Pleistocene glaciations, we know little about how ancient climate changes drove the development of cave-dwelling organisms living at both middle and lower latitudes...
October 21, 2017: Global Change Biology
https://www.readbyqxmd.com/read/29055114/sorafenib-response-in-hepatocellular-carcinoma-micrornas-as-tuning-forks-mirnas-as-regulators-of-sorafenib-response-in-hcc
#5
REVIEW
Shruthi Kanthaje, Ankita Makol, Anuradha Chakraborti
Hepatocellular carcinoma (HCC), the primary liver malignancy attributes towards the second foremost cause of cancer related mortality. The targeted chemotherapeutic agent, sorafenib is known to exhibit a statistically significant but limited overall survival advantage in advanced HCC. However, the individual patient response towards sorafenib varies drastically with most of them demonstrating stable disease (SD), few with partial response (PR) and very rare complete response (CR). Progressive disease (PD) despite the treatment has also been demonstrated in many patients indicating drug resistance...
October 20, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29055113/accelerating-patient-access-to-novel-biologics-using-stable-pool-derived-product-for-non-clinical-studies-and-single-clone-derived-product-for-clinical-studies
#6
Trent P Munro, Kim Le, Huong Le, Li Zhang, Jennitte Stevens, Neil Soice, Sabrina A Benchaar, Robert W Hong, Chetan T Goudar
Cell cloning and subsequent process development activities are on the critical path directly impacting the timeline for advancement of next generation therapies to patients with unmet medical needs. The use of stable cell pools for early stage material generation and process development activities is an enabling technology to reduce timelines. To successfully use stable pools during development, it is important that bioprocess performance and requisite product quality attributes be comparable to those observed from clonally derived cell lines...
October 21, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/29055111/genetic-based-dissection-of-arsenic-accumulation-in-maize-using-a-genome-wide-association-analysis-method
#7
Zhan Zhao, Huaisheng Zhang, Zhongjun Fu, Hao Chen, Yanan Lin, Pengshuai Yan, Weihua Li, Huiling Xie, Zhanyong Guo, Xuehai Zhang, Jihua Tang
Understanding the mechanism of arsenic (As) accumulation in plants is important in reducing As's toxicity to plants and its potential risks to human health. Here, we performed a genome-wide association study to dissect the genetic basis of the As contents of different maize tissues in Xixian, which was irrigated with As-rich surface water, and Changge using an association population consisting of 230 representative inbred maize lines. Phenotypic data revealed a wide normal distribution and high repeatability for the As contents in maize tissues...
October 21, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29055106/streptavidin-coated-surfaces-suppress-bacterial-colonisation-by-inhibiting-non-specific-protein-adsorption
#8
Volker Ettelt, Katharina Ekat, Peer W Kämmerer, Bernd Kreikemeyer, Matthias Epple, Michael Veith
Streptavidin is a 58 kDa tetrameric protein with the highest known affinity to biotin with a wide range of applications in bionanotechnology and molecular biology. Dissolved streptavidin is stable at a broad range of temperature, pH, proteolytic enzymes and exhibits low non-specific binding. In this study, a streptavidin monolayer was assembled directly on a biotinylated TiO2 -surface to investigate its stability against proteolytic digestion and its suppression of initial bacterial adsorption of Escherichia coli, Bacillus subtilis, and Streptococcus intermedius...
October 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29054986/phase-1-study-of-enavatuzumab-a-first-in-class-humanized-monoclonal-antibody-targeting-the-tweak-receptor-in-patients-with-advanced-solid-tumors
#9
Elaine T Lam, S Gail Eckhardt, Wells Messersmith, Antonio Jimeno, Cindy L O'Bryant, Ramesh K Ramanathan, Glen J Weiss, Manpreet Chadha, Abbie Oey, Han Ting Ding, Patricia A Culp, Stephan F Keller, Vivian Y Zhao, L Claire Tsao, Anil Singhal, Kyle D Holen, Daniel D Von Hoff
This phase I study evaluates the safety, maximum tolerated dose (MTD), pharmacokinetics (PK), pharmacodynamics, and preliminary anticancer activity of enavatuzumab, a humanized IgG1 antibody to the TWEAK receptor, in patients with advanced solid malignancies. Patients received escalating doses of enavatuzumab given intravenously over 60 minutes every 2 weeks. Blood was obtained for PK and biomarker assessment. Three patients were enrolled per dose level in a standard 3+3 design with response assessment by RECIST version 1...
October 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29054974/laryngeal-closure-impedes-non-invasive-ventilation-at-birth
#10
Jessica R Crawshaw, Marcus J Kitchen, Corinna Binder-Heschl, Marta Thio, Megan J Wallace, Lauren T Kerr, Charles C Roehr, Katie L Lee, Genevieve A Buckley, Peter G Davis, Andreas Flemmer, Arjan B Te Pas, Stuart B Hooper
BACKGROUND: Non-invasive ventilation is sometimes unable to provide the respiratory needs of very premature infants in the delivery room. While airway obstruction is thought to be the main problem, the site of obstruction is unknown. We investigated whether closure of the larynx and epiglottis is a major site of airway obstruction. METHODS: We used phase contrast X-ray imaging to visualise laryngeal function in spontaneously breathing premature rabbits immediately after birth and at approximately 1 hour after birth...
October 20, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29054872/transcriptional-activities-of-the-microbial-consortium-living-with-the-marine-nitrogen-fixing-cyanobacterium-trichodesmium-reveal-potential-roles-in-community-level-nitrogen-cycling
#11
Michael D Lee, Eric A Webb, Nathan G Walworth, Fei-Xue Fu, Noelle A Held, Mak A Saito, David A Hutchins
Trichodesmium are globally distributed cyanobacteria whose nitrogen-fixing capabilities fuel primary production in warm, oligotrophic oceans. Like many photoautotrophs, Trichodesmium serve as hosts to various other microorganisms, yet little is known about how this associated community modulates fluxes of environmentally relevant chemical species into and out of the supraorganismal structure. Here we utilized metatranscriptomics to examine gene-expression activities of microbial communities associated with Trichodesmium erythraeum (strain IMS101) using laboratory-maintained enrichment cultures that have previously been shown to harbor similar microbial communities to those of natural populations...
October 20, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29054815/whole-brain-radiotherapy-or-autologous-stem-cell-transplantation-as-consolidation-strategies-after-high-dose-methotrexate-based-chemoimmunotherapy-in-patients-with-primary-cns-lymphoma-results-of-the-second-randomisation-of-the-international-extranodal-lymphoma
#12
Andrés J M Ferreri, Kate Cwynarski, Elisa Pulczynski, Christopher P Fox, Elisabeth Schorb, Paul La Rosée, Mascha Binder, Alberto Fabbri, Valter Torri, Eleonora Minacapelli, Monica Falautano, Fiorella Ilariucci, Achille Ambrosetti, Alexander Roth, Claire Hemmaway, Peter Johnson, Kim M Linton, Tobias Pukrop, Jette Sønderskov Gørløv, Monica Balzarotti, Georg Hess, Ulrich Keller, Stephan Stilgenbauer, Jens Panse, Alessandra Tucci, Lorella Orsucci, Francesco Pisani, Alessandro Levis, Stefan W Krause, Hans J Schmoll, Bernd Hertenstein, Mathias Rummel, Jeffery Smith, Michael Pfreundschuh, Giuseppina Cabras, Francesco Angrilli, Maurilio Ponzoni, Martina Deckert, Letterio S Politi, Jürgen Finke, Michele Reni, Franco Cavalli, Emanuele Zucca, Gerald Illerhaus
BACKGROUND: The International Extranodal Lymphoma Study Group-32 (IELSG32) trial is an international randomised phase 2 study that addresses two key clinical questions in the treatment of patients with newly diagnosed primary CNS lymphoma. Results of the first randomisation have demonstrated that methotrexate, cytarabine, thiotepa, and rituximab (called the MATRix regimen) is the induction combination associated with significantly better outcome compared with the other induction combinations tested...
October 17, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/29054812/the-impact-of-inter-annual-rainfall-variability-on-african-savannas-changes-with-mean-rainfall
#13
Alexis D Synodinos, Britta Tietjen, Dirk Lohmann, Florian Jeltsch
Savannas are mixed tree-grass ecosystems whose dynamics are predominantly regulated by resource competition and the temporal variability in climatic and environmental factors such as rainfall and fire. Hence, increasing inter-annual rainfall variability due to climate change could have a significant impact on savannas. To investigate this, we used an ecohydrological model of stochastic differential equations and simulated African savanna dynamics along a gradient of mean annual rainfall (520-780 mm/year) for a range of inter-annual rainfall variabilities...
October 17, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/29054782/multi-level-spondylolysis-repair-using-the-smiley-face-technique-with-3d-intraoperative-spinal-navigation
#14
Mathew R Voisin, Christopher D Witiw, Ryan Deorajh, Daipayan Guha, Adetunji Oremakinde, Shelly Wang, Victor Yang
BACKGROUND / OBJECTIVE: Multi-level spondylolysis is a rare cause of progressive lower back pain and patients that fail conservative management are treated surgically. Direct repair methods can maintain mobility and lead to decreased morbidity compared with spinal fusion in single-level spondylolysis. In this paper, we present a patient with non-adjacent multi-level spondylolysis that underwent the 'smiley face' technique of direct multi-level repair without fusion using 3D intraoperative spinal navigation...
October 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29054760/polymorphisms-of-vitamin-k-related-genes-ephx1-and-vkorc1l1-and-stable-warfarin-doses
#15
Jee-Eun Chung, Kyung Eun Lee, Byung Chul Chang, Hye Sun Gwak
The aim of this study was to investigate the possible effects of EPHX1 and VKORC1L1 polymorphisms on variability of responses to warfarin. Sixteen single nucleotide polymorphisms (SNPs) in 201 patients with stable warfarin doses were analyzed including genes of VKORC1, CYP2C9, CYP4F2, GGCX, EPHX1 and VKORC1L1. Univariate analysis was conducted for the association of genotypes with stable warfarin doses. Multiple linear regression analysis was used to investigate factors that independently affected the inter-individual variability of warfarin dose requirements...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29054717/-evaluation-of-quality-of-life-qol-of-tunisians-patients-with-copd
#16
R Khalladi, I Gargouri, M Mahjoub, S Belhareth, H Ben Saad
AIM: To test the Arabic version of the St. George's Hospital Respiratory Questionnaire (SGRQ) in stable Tunisian COPD patients. HYPOTHESES: A correlation coefficient between the post-bronchodilator FEV1 and the "Total" score of SGRQ higher than "-0.40", and QOL scores lower in COPD with "mild to moderate airway obstruction" than in those with "severe to very severe airway obstruction" will be in favor of a possible application of the Arabic version of the SGRQ in Tunisians COPD patients...
October 17, 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29054692/plasmacytoid-dendritic-cells-drive-acute-exacerbations-of-asthma
#17
Aikaterini-Dimitra Chairakaki, Maria-Ioanna Saridaki, Katerina Pyrillou, Marios-Angelos Mouratis, Ourania Koltsida, Ross P Walton, Nathan W Bartlett, Athanasios Stavropoulos, Louis Boon, Nikoletta Rovina, Nikolaos G Papadopoulos, Sebastian L Johnston, Evangelos Andreakos
BACKGROUND: Although acute exacerbations, mostly triggered by viruses, account for the majority of hospitalizations in asthma, there is still very little known about the pathophysiological mechanisms involved. Plasmacytoid DCs (pDCs), prominent cells of antiviral immunity, exhibit pro-inflammatory or tolerogenic functions depending on the context, yet their involvement in asthma exacerbations remains unexplored. OBJECTIVES: We sought to investigate the role of pDCs in allergic airway inflammation and acute exacerbations of asthma...
October 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29054650/vitamin-b12-effects-on-chlorinated-methanes-degrading-microcosms-dual-isotope-and-metabolically-active-microbial-populations-assessment
#18
Diana Rodríguez-Fernández, Clara Torrentó, Miriam Guivernau, Marc Viñas, Daniel Hunkeler, Albert Soler, Cristina Domènech, Mònica Rosell
Field-derived anoxic microcosms were used to characterize chloroform (CF) and carbon tetrachloride (CT) natural attenuation to compare it with biostimulation scenarios in which vitamin B12 was added (B12/pollutant ratio of 0.01 and 0.1) by means of by-products, carbon and chlorine compound-specific stable-isotope analysis, and the active microbial community through 16S rRNA MiSeq high-throughput sequencing. Autoclaved slurry controls discarded abiotic degradation processes. B12 catalyzed CF and CT biodegradation without the accumulation of dichloromethane, carbon disulphide, or CF...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054640/apportioning-source-of-erosion-induced-organic-matter-in-the-hilly-gully-region-of-loess-plateau-in-china-insight-from-lipid-biomarker-and-isotopic-signature-analysis
#19
Chun Liu, Zhongwu Li, Xiaofeng Chang, Xiaodong Nie, Lin Liu, Haibing Xiao, Danyang Wang, Hao Peng, Guangming Zeng
Understanding the dynamics of organic matter (OM) at global and local scales is one of the challenges in the environmental sciences and i.e. terrestrial biogeochemistry. The accurate identification of OM is an essential element to achieve this goal. In our study, a novel application for quantitatively apportioning sources of eroded sedimentary OM from an eco-geomorphologic perspective was shown successfully via a coupled molecular n-alkane biomarkers and stable isotopic signatures ((13)C and (15)N) along with elemental compositions (TOC and TN) using a Bayesian mixing model (SIAR)...
October 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29054622/effect-of-a-strengthened-ecological-floating-bed-on-the-purification-of-urban-landscape-water-supplied-with-reclaimed-water
#20
Wen-Huai Wang, Yi Wang, Zhi Li, Cun-Zhi Wei, Jing-Chan Zhao, Lu-Qin Sun
A floating bed (FB) system vegetated with calamus, iris, lythrum, and Hydrocotyle vulgaris, and a strengthened FB (SFB) system with zeolite and sponge iron as fillers were simultaneously applied to purify urban landscape water in different zones. The urban landscape water, an artificial lake of approximately 326m(2), was supplied with reclaimed water during a six-month experiment. Results indicated that the concentrations of nitrogen (N) and phosphorus (P) in the SFB zone (SFBZ) were significantly lower than those in the control zone (CZ) and the FB zone (FBZ) after six months of operation...
October 17, 2017: Science of the Total Environment
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