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Rahim Bagheri, Hadi Jafari, Fatemeh Bagheri
Badab Sourt travertine-depositing springs in the north of Iran, naturally create a unique surreal landscape containing a range of stepped travertine terraces, similarly found only in a few other places on earth. This site comprises of three travertine saline springs with different values of salinity and discharge (SP1 , SP2 , and SP3 ) and one non-travertine fresh karstic spring (SP4 ) within a distance of about 300 m. The etiology behind this salinity and the water origin are the main research's dilemma that were investigated using geological, hydrochemical, and stable isotopic techniques...
December 14, 2017: Ground Water
ElisabethJohanna Grub, Georg Wydra, Michael Käfer, Volker Köllner
Aim of the study For many rehabilitants both the motor balance and the feeling of being emotionally stable and in balance are essential preconditions for participation in employment and society. The goal of this study was to capture changes in motor balance in the course of an inpatient psychosomatic rehabilitation and to set them in relation to changes in mental variables. Methods 118 patients of a psychosomatic clinic (49.3±8.6 years; 75.4 % women) were examined at the beginning and the end of rehabilitation...
December 2017: Die Rehabilitation
Jiangmin Zhao, Le Li, Qian Wang, Hongxiu Han, Qing Zhan, Ming Xu
BACKGROUND/AIMS: Lung adenocarcinoma, a form of non-small cell lung cancer with high lethality at an advanced stage, is becoming more common in women, non- or never-smokers, and even young adults. At present, there are still no effective early diagnosis methods for patients to be cured in a timely manner. Circular RNAs (circRNAs), which are stable and conserved non-coding RNA in mammalian cells, have been reported to be widely involved in the processes of cancer disease. However, it is still a puzzle as to which specific circRNAs are involved in the development of early-stage lung adenocarcinoma...
December 12, 2017: Cellular Physiology and Biochemistry
Robert E Harris, Jessica Richardson, Rosemary Frasso, Evan D Anderson
BACKGROUND: People who inject drugs (PWID) are at high risk for infectious diseases, skin and soft tissue infections, and overdose. However, these harms are all avoidable when sterile injection equipment, hygienic places to inject, and medical care are accessible. Unfortunately, many PWID in the U.S lack these resources. The most vulnerable are forced to inject in public spaces, where individual risks are high and communal harms are sometimes many. Supervised Injection Facilities (SIFs) are an established intervention for reducing these harms...
December 10, 2017: International Journal on Drug Policy
Qiunan Lyu, Bowen Hu, Chunguang Zhou, Limin Liu, Yueming Song, Xi Yang, Liang Wang, Lei Wang
OBJECTIVE: Hemivertebrae (HV) located at the lower lumbar or lumbosacral region often produce early trunk imbalance and long compensatory curves. Because of the biomechanical characteristics of the lumbosacral junction, the rate of instrumentation failures at the region has always been high. Our study aimed to evaluate the results of posterior HV resection with lumbosacral fixation and fusion in the treatment of congenital scoliosis and to make a preliminary analysis of the possible risk factors for instrument failures...
December 9, 2017: Clinical Neurology and Neurosurgery
Emmanuel Njumbe Ediage, Lieve Dillen, Ann Vroman, Luc Diels, Annett Kunze, Jan Snoeys, Tom Verhaeghe
Coproporphyrins are proposed as endogenous biomarkers of hepatic Organic Anion Transporting Polypeptide (OATP)1B functional activity. In this study, a new sample extraction method based on a mixed-mode anion exchange sorbent (SPE clean-up using Oasis 30mg Max 96 well plates) was developed for absolute quantification of coproporphyrin I and III (CP-I and CP-III) in human plasma. Chromatographic separation was performed with an Ace Excel 2 C18 PFP, 3μm, 2.1×150mm, maintained at 60°C. A 10mM ammonium formate containing 0...
December 6, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Tiantian Li, Radley M Horton, Daniel A Bader, Fangchao Liu, Qinghua Sun, Patrick L Kinney
BACKGROUND: Changing climates have been causing variations in the number of global ischemic heart disease and stroke incidences, and will continue to affect disease occurrence in the future. OBJECTIVES: To project temperature-related mortality for acute ischemic heart disease, and ischemic and hemorrhagic stroke with concomitant climate warming. METHODS: We estimated the exposure-response relationship between daily cause-specific mortality and daily mean temperature in Beijing...
December 11, 2017: Environment International
Caleb F Harris, Christopher S Kuehner, John Bacsa, Jake D Soper
Visible light capture activates a thermodynamically inert CoIII-CF3 bond for direct C-H trifluoromethylation of arenes and heteroarenes. New trifluoromethylcobalt(III) complexes supported by a redox-active [OCO] pincer ligand were prepared. Coordinating solvents, such as MeCN, afford quasi-octahedral [(SOCO)CoIII(CF3)(MeCN)2] (2), but in non-coordinating solvents the complex is square pyramidal [(SOCO)CoIII(CF3)(MeCN)] (3). Both are thermally stable, and 2 is stable in light. But exposure of 3 to low-energy light results in facile homolysis of the CoIII-CF3 bond, releasing ●CF3 radical, which is trapped by TEMPO● or (hetero)arenes...
December 14, 2017: Angewandte Chemie
Carlton J Bequette, Sarah R Hind, Sarah Pulliam, Rebecca Higgins, Johannes W Stratmann
Plant responses to the environment and developmental processes are mediated by a complex signaling network. The Arabidopsis thaliana mitogen-activated protein kinases (MAPKs) MPK3 and MPK6 and their orthologs in other plants are shared signal transducers that respond to many developmental and environmental signals and thus represent highly connected hubs in the cellular signaling network. In animals, specific MAPK signaling complexes are assembled which enable input-specific protein-protein interactions and thus specific signaling outcomes...
December 12, 2017: Journal of Experimental Botany
Luke Springall, Craig D Hughes, Michelle Simons, Stavros Azinas, Bennett Van Houten, Neil M Kad
Nucleotide excision repair (NER) is the primary mechanism for removal of ultraviolet light (UV)-induced DNA photoproducts and is mechanistically conserved across all kingdoms of life. Bacterial NER involves damage recognition by UvrA2 and UvrB, followed by UvrC-mediated incision either side of the lesion. Here, using a combination of in vitro and in vivo single-molecule studies we show that a UvrBC complex is capable of lesion identification in the absence of UvrA. Single-molecule analysis of eGFP-labelled UvrB and UvrC in living cells showed that UV damage caused these proteins to switch from cytoplasmic diffusion to stable complexes on DNA...
December 12, 2017: Nucleic Acids Research
Jonathan R Thompson, Joshua S Plisinski, Pontus Olofsson, Christopher E Holden, Matthew J Duveneck
New England has lost more than 350,000 ha of forest cover since 1985, marking a reversal of a two-hundred-year trend of forest expansion. We a cellular land-cover change model to project a continuation of recent trends (1990-2010) in forest loss across six New England states from 2010 to 2060. Recent trends were estimated using a continuous change detection algorithm applied to twenty years of Landsat images. We addressed three questions: (1) What would be the consequences of a continuation of the recent trends in terms of changes to New England's forest cover mosaic? (2) What social and biophysical attributes are most strongly associated with recent trends in forest loss, and how do these vary geographically? (3) How sensitive are projections of forest loss to the reference period-i...
2017: PloS One
Kristin Haynert, Mirijam Kiggen, Bernhard Klarner, Mark Maraun, Stefan Scheu
Mesofauna taxa fill key trophic positions in soil food webs, even in terrestrial-marine boundary habitats characterized by frequent natural disturbances. Salt marshes represent such boundary habitats, characterized by frequent inundations increasing from the terrestrial upper to the marine pioneer zone. Despite the high abundance of soil mesofauna in salt marshes and their important function by facilitating energy and carbon flows, the structure, trophic ecology and habitat-related diet shifts of mesofauna species in natural salt marsh habitats is virtually unknown...
2017: PloS One
Fengming Yu, Yoji Okabe
Recently, the authors have proposed a remote acoustic emission (AE) measurement configuration using a sensitive fiber-optic Bragg grating (FBG) sensor. In the configuration, the FBG sensor was remotely bonded on a plate, and an optical fiber was used as the waveguide to propagate AE waves from the adhesive point to the sensor. The previous work (Yu et al., Smart Materials and Structures 25 (10), 105,033 (2016)) has clarified the sensing principle behind the special remote measurement system that enables accurate remote sensing of AE signals...
December 14, 2017: Sensors
Alexander A Fokin, Ivan Puente, Nir Huss, Eugenio Rodriguez, Russell D Weisz
Use of biologic scaffolds such as extracellular matrix (ECM) is a promising 4 trend in the treatment of complex wounds in orthopaedic trauma patients.In this clinical series we describe the technique of the successful application of porcine urinary bladder ECM products in the treatment of open fractures of the extremities with complex wounds and large soft tissue defects. The clinical outcomes demonstrated that even in challenging cases where local flap coverage of bone or neurovascular structures is not possible, sequential xenograft implantation allowed us to achieve a stable soft tissue envelope...
December 13, 2017: Journal of Orthopaedic Trauma
Sunita Thapa, Arielle S Selya, Yvonne Jonk
INTRODUCTION: Children of alcoholic parents are at increased risk for lifetime depression. However, little is known about how this risk may change in magnitude across age, especially in mid-adulthood and beyond. METHODS: We used a nationally representative sample (N = 36,057) of US adults from the National Epidemiologic Survey on Alcohol and Related Conditions, wave III. After adjusting for demographic characteristics, we examined the relationship between parental alcoholism and outcomes of 1) major depressive disorder, Diagnostic and Statistical Manual of Mental Disorders-5th edition (DSM-5) and 2) DSM-5 persistent depressive disorder...
December 14, 2017: Preventing Chronic Disease
Paolo Andrea Zucali, Tommaso De Pas, Giovannella Palmieri, Adolfo Favaretto, Antonio Chella, Marcello Tiseo, Michele Caruso, Matteo Simonelli, Matteo Perrino, Fabio De Vincenzo, Francesca Toffalorio, Vincenzo Damiano, Giulia Pasello, Erika Garbella, Marco Ali, Fabio Conforti, Margaret Ottaviano, Angela Cioffi, Sabino De Placido, Laura Giordano, Monica Bertossi, Annarita Destro, Luca Di Tommaso, Armando Santoro
Purpose No effective salvage treatments are available for patients with advanced/recurrent thymoma (T) or thymic carcinoma (TC) who have progressed after platinum-based chemotherapy. This study evaluated the activity of everolimus in patients with advanced/recurrent T or TC previously treated with cisplatin-containing chemotherapy. Patients and Methods This was a single-arm, single-stage, open-label, multicenter, phase II trial. Patients received oral everolimus 10 mg/d until disease progression, unacceptable toxicity, or patient refusal...
December 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
H K Hussein, Plr Nicolson, K Fordwor, G C Lowe
Patients with mild bleeding disorders are under-recognized and frequently present to general physicians. The underlying reasons for bleeding are multifactorial. There is little evidence to guide diagnostic and management decision making in patients with mild bleeding disorders. This article outlines different types of mild bleeding disorders, with a particular focus on bleeding associated with low levels of von Willebrand factor and mild platelet defects. It gives practical, evidence-based advice on the investigation and management of patients with a suspected or known mild bleeding disorder, considering the scenarios of an acute bleed, stable outpatient, peri-surgical management and thrombosis...
December 2, 2017: British Journal of Hospital Medicine
Rezvan Chitsazi, Jeffrey D Veals, Yi Shi, Tommy Sewell
Density functional theory (DFT) and ab initio electronic structure calculations were used to study the Al + CO2 → AlO + CO reaction on the electronic ground-state potential-energy surface (PES). Geometries were optimized using DFT (M11/jun-cc-pV(Q+d)Z) and more accurate energies were obtained using the composite Weizmann-1 theory with Brueckner doubles (W1BD). The results comprise the most complete, most systematic characterization of the Al + CO2 reaction surface to date and are based on consistent application of high-level methods for all stationary points identified...
December 14, 2017: Journal of Physical Chemistry. A
Samar Kumar Das, Subhabrata Mukhopadhyay, Joyashish Debgupta, Chandani Singh, Aranya Kar
Keggin type of polyoxometalate anions, [XM12O40]n-, are as versatile as their applications in interdisciplinary areas. We have shown that Keggin anion [CoW12O40]6- turns into an efficient and robust electrocatalyst upon its confinement in the well-defined void space of ZIF-8, a metal organic framework (MOF). We have demonstrated that [H6CoW12O40]@ZIF-8 is so stable to water oxidation, that it retains its initial activity even after 1000 catalytic cycles. The catalyst shows turnover frequency (TOF) of 10.8 mol O2(mol Co)-1s-1...
December 14, 2017: Angewandte Chemie
Markus Wiesemann, Johannes Klösener, Beate Neumann, Hans-Georg Stammler, Berthold Hoge
The tin-tin bond cleavage of hexaorganodistannanes by nucleophiles is a long known reaction and widely used for stannate formation or stannyl group transfer. Herein we detail our experiments to provide analytical evidence for the existence of reasonably stable anionic complexes [XSn(C2F5)3{Sn(C2F5)3}]- (X = Cl, Br, I, Sn(C2F5)3) derived from hexakis(pentafluoroethyl)distannane. NMR investigations at low temperature lend further mechanistic insights. Thus, by detection of the imposing anion [Sn(C2F5)3{Sn(C2F5)3}2]-, one can surmise that the chemistry of Sn2(C2F5)6 has more in common with the isolobal iodine than with classical distannanes...
December 14, 2017: Chemistry: a European Journal
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