keyword
MENU ▼
Read by QxMD icon Read
search

Knowledge translation

keyword
https://www.readbyqxmd.com/read/28654728/finding-similar-nucleotide-sequences-using-network-blast-searches
#1
Istvan Ladunga
The Basic Local Alignment Search Tool (BLAST) is the first tool in the annotation of nucleotide or amino acid sequences. BLAST is a flagship of bioinformatics due to its performance and user-friendliness. Beginners and intermediate users will learn how to design and submit blastn and Megablast searches on the Web pages at the National Center for Biotechnology Information. We map nucleic acid sequences to genomes, find identical or similar mRNAs, expressed sequence tag, and noncoding RNA sequences, and run Megablast searches, which are much faster than blastn...
June 27, 2017: Current Protocols in Bioinformatics
https://www.readbyqxmd.com/read/28654541/caring-for-older-surgical-patients-contemporary-attitudes-knowledge-practices-and-needs-of-general-surgeons-and-residents
#2
Tyler R Chesney, George Pang, Najma Ahmed
OBJECTIVE: To gain contemporary insights from residents and surgeons regarding the care of older surgical patients. BACKGROUND DATA: With worldwide aging, efforts over the past decade have attempted to increase surgeons' abilities to care for older adults, but a current understanding of attitudes, knowledge, practices, and needs is missing. METHODS: Between July 2016 and September 2016 we conducted a national Web-based survey sampling all general surgery residents and academic general surgeons using a questionnaire designed and tested for this purpose...
June 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28654479/knowledge-translation-in-rehabilitation-a-shared-vision
#3
Jennifer L Moore, Keiko Shikako-Thomas, Deborah Backus
PURPOSE: Advances in rehabilitation provide the infrastructure for research and clinical data to improve care and patient outcomes. However, gaps between research and practice are prevalent. Knowledge translation (KT) aims to decrease the gap between research and its clinical use. This special communication summarizes KT-related proceedings from the 2016 IV STEP conference, describes current KT in rehabilitation science, and provides suggestions for its application in clinical care. SUMMARY OF KEY POINTS: We propose a vision for rehabilitation clinical practice and research that includes the development, adaptation, and implementation of evidence-based practice recommendations, which will contribute to a learning health care system...
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654069/optimized-protocol-for-the-extraction-of-proteins-from-the-human-mitral-valve
#4
Cristina Banfi, Anna Guarino, Maura Brioschi, Stefania Ghilardi, Valeria Mastrullo, Elena Tremoli, Gianluca Polvani
Analysis of the cellular proteome can help to elucidate the molecular mechanisms underlying diseases due to the development of technologies that permit the large-scale identification and quantification of the proteins present in complex biological systems.The knowledge gained from a proteomic approach can potentially lead to a better understanding of the pathogenic mechanisms underlying diseases, allowing for the identification of novel diagnostic and prognostic disease markers, and, hopefully, of therapeutic targets...
June 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28653443/stem-cell-derived-extracellular-vesicles-as-a-novel-potential-therapeutic-tool-for-tissue-repair
#5
EDITORIAL
Bi Chen, Qing Li, Bizeng Zhao, Yang Wang
Stem cells, with their therapeutic potential in tissue repair and regeneration, have been widely used in translational medicine. Recent evidence suggests that the beneficial effects are mediated largely by their paracrine actions rather than the engraftment and differentiation at the injured sites. Extracellular vesicles (EVs), actively released from cells, play important roles in cell-to-cell communication and display multiple functions in tissue regeneration. In this present report, we will briefly review the current knowledge related to the therapeutic potential of EVs, particularly stem cell or progenitor cell-derived ones for promoting tissue repair and regeneration, and focus on the restorative properties of exosomes/microvesicles in cutaneous wound healing, bone regeneration, hindlimb ischemia, and vascular injury repair...
June 27, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28652803/effects-of-acculturation-coping-strategies-locus-of-control-and-self-efficacy-on-chronic-pain-study-of-chinese-immigrant-women-in-italy-insights-from-a-thematic-field-analysis
#6
Tania Simona Re, Nicola Luigi Bragazzi, Anna Siri, César Cisneros Puebla, Susanne Friese, Mário Simões, Joël Candau, Hicham Khabbache
Chronic pain represents a common public health concern worldwide. It is a complex phenomenon, owing to the interaction of different factors, including biological, physiological, psychological, environmental, and social variables. Some groups, such as women and immigrants, are particularly vulnerable. However, little is known about how Chinese women in Italy live with and face chronic pain. The present study aimed at filling this knowledge gap by examining the burden of chronic pain in Chinese immigrants in Italy in terms of acculturation processes, perceived control over disease, social networks, and coping strategies...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28652179/non-coding-rna-regulation-of-t-cell-biology-implications-for-age-associated-cardiovascular-diseases
#7
REVIEW
Jose Coelho-Lima, Ioakim Spyridopoulos
Prevalence of age-associated cardiovascular diseases (CVD) has dramatically increased as a result of improvements in life expectancy. Chronic inflammation is a shared pathophysiological feature of age-associated CVDs, indicating a role for the immune system in the onset and development of CVDs. Indeed, ageing elicits profound changes in both the cardiovascular and immune system, especially in the T cell compartment. Although such changes have been well described at the cellular level, the molecular mechanisms underlying immune-mediated cardiovascular ageing remain largely unexplored...
June 23, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28651530/perspectives-of-health-care-professionals-on-the-facilitators-and-barriers-to-the-implementation-of-a-stroke-rehabilitation-guidelines-cluster-randomized-controlled-trial
#8
Sarah E P Munce, Ian D Graham, Nancy M Salbach, Susan B Jaglal, Carol L Richards, Janice J Eng, Johanne Desrosiers, Marilyn MacKay-Lyons, Sharon Wood-Dauphinee, Nicol Korner-Bitensky, Nancy E Mayo, Robert W Teasell, Merrick Zwarenstein, Jennifer Mokry, Sandra Black, Mark T Bayley
BACKGROUND: The Stroke Canada Optimization of Rehabilitation by Evidence Implementation Trial (SCORE-IT) was a cluster randomized controlled trial that evaluated two knowledge translation (KT) interventions for the promotion of the uptake of best practice recommendations for interventions targeting upper and lower extremity function, postural control, and mobility. Twenty rehabilitation centers across Canada were randomly assigned to either the facilitated or passive KT intervention. The objective of the current study was to understand the factors influencing the implementation of the recommended treatments and KT interventions from the perspective of nurses, occupational therapists and physical therapists, and clinical managers following completion of the trial...
June 26, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28649785/stari-aims-to-overcome-knowledge-translation-inertia-the-standards-for-reporting-implementation-studies-guidelines
#9
EDITORIAL
Christopher R Carpenter, Hilary Pinnock
No abstract text is available yet for this article.
June 26, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28649447/certification-of-clinical-and-translational-researchers-an-ill-conceived-notion
#10
EDITORIAL
Paul R Marantz, Harry P Selker, Emma A Meagher
The National Board of Medical Examiners (NBME) has instituted a new multiple choice examination in order to "certify" clinical and translational investigators. As experienced research educators, we argue that this certification process is unnecessary, values knowledge over competency, may be counter-productive, and is unlikely to achieve any worthwhile outcome. We lay out these arguments in the hope of stimulating a robust discussion among leaders, faculty, and learners engaged in clinical research education and training...
February 2017: Journal of clinical and translational science
https://www.readbyqxmd.com/read/28649438/translational-learning-from-clinical-studies-predicts-drug-pharmacokinetics-across-patient-populations
#11
Markus Krauss, Ute Hofmann, Clemens Schafmayer, Svitlana Igel, Jan Schlender, Christian Mueller, Mario Brosch, Witigo von Schoenfels, Wiebke Erhart, Andreas Schuppert, Michael Block, Elke Schaeffeler, Gabriele Boehmer, Linus Goerlitz, Jan Hoecker, Joerg Lippert, Reinhold Kerb, Jochen Hampe, Lars Kuepfer, Matthias Schwab
Early indication of late-stage failure of novel candidate drugs could be facilitated by continuous integration, assessment, and transfer of knowledge acquired along pharmaceutical development programs. We here present a translational systems pharmacology workflow that combines drug cocktail probing in a specifically designed clinical study, physiologically based pharmacokinetic modeling, and Bayesian statistics to identify and transfer (patho-)physiological and drug-specific knowledge across distinct patient populations...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28648568/application-of-machine-learning-classification-for-structural-brain-mri-in-mood-disorders-critical-review-from-a-clinical-perspective
#12
REVIEW
Yong-Ku Kim, Kyoung-Sae Na
Mood disorders are a highly prevalent group of mental disorders causing substantial socioeconomic burden. There are various methodological approaches for identifying the underlying mechanisms of the etiology, symptomatology, and therapeutics of mood disorders; however, neuroimaging studies have provided the most direct evidence for mood disorder neural substrates by visualizing the brains of living individuals. The prefrontal cortex, hippocampus, amygdala, thalamus, ventral striatum, and corpus callosum are associated with depression and bipolar disorder...
June 22, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28647910/perception-of-spirituality-and-spiritual-care-among-muslim-nurses-in-indonesia
#13
Risa Herlianita, Miaofen Yen, Ching-Huey Chen, Susan J Fetzer, Esther Ching-Lan Lin
This cross-sectional study was conducted to examine 256 Muslim nurses' perception of spirituality and spiritual care in Indonesia. The Spirituality and Spiritual Care Rating Scale (SSCRS) was translated and culturally adapted. Moderately high degrees in five domains and total SSCRS were found. Specialty, education level, clinical seniority, having spiritual training, and previous spiritual caring experience could impact on the SSCRS. Most nurses have cared for patients with spiritual needs, but denied having any formal training in providing spiritual care...
June 24, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28647171/worm-control-in-livestock-bringing-science-to-the-field
#14
REVIEW
Fiona Kenyon, Fiona Hutchings, Claire Morgan-Davies, Jan van Dijk, Dave J Bartley
Parasitic roundworm infections are ubiquitous in grazing livestock. Chemical control through the frequent 'blanket' administration of anthelmintics (wormers) has been, and remains, the cornerstone in controlling these infections, but this practice is unsustainable. Alternative strategies are available but, even with the plethora of best practice advice available, have yet to be integrated into routine farming practice. This is probably due to a range of factors, including contradictory advice from different sources, changes to advice following increased scientific understanding, and top-down knowledge exchange patterns...
June 21, 2017: Trends in Parasitology
https://www.readbyqxmd.com/read/28645931/a-potential-role-of-the-unfolded-protein-response-in-post-transplant-cancer
#15
REVIEW
Sandra Bodeau, Chloé Sauzay, Olivier Pluquet, Gabriel Choukroun, Antoine Galmiche
Cancer is one of the major causes of mortality in organ transplant patients receiving immunosuppressive regimen based on Cyclosporin A (CsA). Organ transplantation and chronic immunosuppression are typically associated with skin cancers (both squamous cell carcinoma and melanoma) and renal cell carcinoma (RCC). Recent studies have shown that in addition to its immunosuppressive effects, accounted for by the inhibition of calcineurin and the modulation of the transcriptional programme of lymphocytes, CsA also directly stimulates the growth and aggressive behaviour of various cancer cells...
July 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28645362/measuring-most-informative-titles-declarative-titles-as-a-knowledge-translation-dissemination-tool-is-possible-using-altmetrics
#16
Jessie McGowan
No abstract text is available yet for this article.
May 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28644300/breathlessness-in-the-primary-care-setting
#17
Noel Baxter
PURPOSE OF REVIEW: Breathlessness is a high-volume problem with 10% of adults experiencing the symptom daily placing a heavy burden on the health and wider economy. As it worsens, they enter the specialist and hospital-based symptom services where costs quickly escalate and people may find themselves in a place not of their choosing. For many, their care will be delivered by a disease or organ specialist and can find themselves passing between physicians without coordination for symptom support...
July 20, 2017: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/28643003/recent-developments-in-solution-nuclear-magnetic-resonance-nmr-based-molecular-biology
#18
REVIEW
Joshua J Ziarek, Diego Baptista, Gerhard Wagner
Visualizing post-translational modifications, conformations, and interaction surfaces of protein structures at atomic resolution underpins the development of novel therapeutics to combat disease. As computational resources expand, in silico calculations coupled with experimentally derived structures and functional assays have led to an explosion in structure-based drug design (SBDD) with several compounds in clinical trials. It is increasingly clear that "hidden" transition-state structures along activation trajectories can be harnessed to develop novel classes of allosteric inhibitors...
June 23, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28642604/turning-the-tide-in-myelodysplastic-myeloproliferative-neoplasms
#19
REVIEW
Michael W N Deininger, Jeffrey W Tyner, Eric Solary
Myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) are aggressive myeloid malignancies recognized as a distinct category owing to their unique combination of dysplastic and proliferative features. Although current classification schemes still emphasize morphology and exclusionary criteria, disease-defining somatic mutations and/or germline predisposition alleles are increasingly incorporated into diagnostic algorithms. The developing picture suggests that phenotypes are driven mostly by epigenetic mechanisms that reflect a complex interplay between genotype, physiological processes such as ageing and interactions between malignant haematopoietic cells and the stromal microenvironment of the bone marrow...
June 23, 2017: Nature Reviews. Cancer
https://www.readbyqxmd.com/read/28642080/impact-of-juvenile-chronic-stress-on-adult-cortico-accumbal-function-implications-for-cognition-and-addiction
#20
REVIEW
Michael J Watt, Matthew A Weber, Shaydel R Davies, Gina L Forster
Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One possible explanation lies in stress-induced disruption to the development of specific brain regions associated with executive function and reward processing, deficits in which are common to the disorders promoted by childhood stress...
June 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
keyword
keyword
8895
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"