keyword
MENU ▼
Read by QxMD icon Read
search

Knowledge translation

keyword
https://www.readbyqxmd.com/read/29667202/knowledge-translation-in-transfusion-medicine-part-3-interventions-and-tools
#1
Ziad Solh, Melissa Brouwers, Ivan D Florez
No abstract text is available yet for this article.
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29666949/precision-medicine-against-alk-positive-non-small-cell-lung-cancer-beyond-crizotinib
#2
REVIEW
Biagio Ricciuti, Andrea De Giglio, Carmen Mecca, Cataldo Arcuri, Sabrina Marini, Giulio Metro, Sara Baglivo, Angelo Sidoni, Guido Bellezza, Lucio Crinò, Rita Chiari
Anaplastic lymphoma kinase (ALK) rearrangements represent the molecular driver of a subset of non-small cell lung cancers (NSCLCs). Despite the initial response, virtually all ALK-positive patients develop an acquired resistance to the ALK inhibitor crizotinib, usually within 12 months. Several next-generation ALK inhibitors have been developed in order to overcome crizotinib limitation, providing an unprecedented survival for this subset of patients. The aim of this review to summarize the current knowledge on ALK tyrosine kinase inhibitors (TKIs) in the treatment of advanced ALK-positive NSCLC, focusing on the role of novel ALK inhibitors in this setting...
April 17, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29666811/immune-checkpoint-pathways-in-non-small-cell-lung-cancer
#3
REVIEW
Young Kwang Chae, Ayush Arya, Wade Iams, Marcello Cruz, Nisha Mohindra, Victoria Villaflor, Francis J Giles
Immunotherapy has evolved at a phenomenal pace in cancer therapeutics. This has primarily been fueled by the much perceived necessity to procure an alternative to current standard of care chemotherapy agents, owing to several concerns such as treatment-related toxicity and poor long-term survival associated with the same. The knowledge of various mechanisms involved in regulation of immune response to cancer cells has served a fundamental role in identifying key molecules through which immune cell activity may be modulated...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666617/perspectives-of-phage-eukaryotic-cell-interactions-to-control-epstein-barr-virus-infections
#4
Andrzej Górski, Ryszard Międzybrodzki, Ewa Jończyk-Matysiak, Beata Weber-Dąbrowska, Natalia Bagińska, Jan Borysowski
Recently, leading medical journals emphasized the importance of further studies on the potential application of bacterial viruses (phages) for the treatment of antibiotics-resistant infections outlining the present status of the therapy and perspectives for the future. Furthermore, a leading scientific journal pointed to the recent progress in research on phage interactions with eukaryotic cells (especially cells of the immune system) and potential implications of their results for our broader understanding of the role of phages - not only as "bacteria eaters" - but also as an important part of our body defense protecting against external and internal pathogenic invaders (as suggested previously)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29665886/antimicrobial-resistance-from-basic-science-to-translational-innovation
#5
Jun Lin
The rise in antimicrobial resistance (AMR) poses a major threat to animal agriculture and human health. To summarize and update current and emerging AMR issues that are significant for animal health and food safety, this issue presents a virtual AMR symposium consisting of seven review papers. These reviews cover a newly described AMR mechanism in Campylobacter, effects of AMR and microbiome on Campylobacter infection, plasmid-mediated colistin resistance in food-producing animals, the impact of point source or antibiotic residues on the environmental resistome, and potential factors influencing horizontal gene transfer in the intestines of food animals...
December 2017: Animal Health Research Reviews
https://www.readbyqxmd.com/read/29665672/regulatory-network-of-arf-in-cancer-development
#6
Aram Ko, Su Yeon Han, Jaewhan Song
ARF is a tumor suppressor protein that has a pivotal role in the prevention of cancer development through regulating cell proliferation, senescence, and apoptosis. As a factor that induces senescence, the role of ARF as a tumor suppressor is closely linked to the p53-MDM2 axis, which is a key process that restrains tumor formation. Thus, many cancer cells either lack a functional ARF or p53, which enables them to evade cell oncogenic stress-mediated cycle arrest, senescence, or apoptosis. In particular, the ARF gene is a frequent target of genetic and epigenetic alterations including promoter hypermethylation or gene deletion...
April 18, 2018: Molecules and Cells
https://www.readbyqxmd.com/read/29664158/spread-of-injectate-around-hip-articular-sensory-branches-of-the-femoral-nerve-in-cadavers
#7
N D Nielsen, M Greher, B Moriggl, R Hoermann, T D Nielsen, J Børglum, T F Bendtsen
BACKGROUND: Anatomical knowledge dictates that regional anaesthesia after total hip arthroplasty requires blockade of the hip articular branches of the femoral and obturator nerves. A direct femoral nerve block increases the risk of fall and impedes mobilisation. We propose a selective nerve block of the hip articular branches of the femoral nerve by an ultrasound-guided injection in the plane between the iliopsoas muscle and the iliofemoral ligament (the iliopsoas plane). The aim of this study was to assess whether dye injected in the iliopsoas plane spreads to all hip articular branches of the femoral nerve...
April 17, 2018: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/29663183/three-visions-of-doctoring-a-gadamerian-dialogue
#8
Benjamin Chin-Yee, Atara Messinger, L Trevor Young
Medicine in the twenty-first century faces an 'identity crisis,' as it grapples with the emergence of various 'ways of knowing,' from evidence-based and translational medicine, to narrative-based and personalized medicine. While each of these approaches has uniquely contributed to the advancement of patient care, this pluralism is not without tension. Evidence-based medicine is not necessary individualized; personalized medicine may be individualized but is not necessarily person-centered. As novel technologies and big data continue to proliferate today, the focus of medical practice is shifting away from the dialogic encounter between doctor and patient, threatening the loss of humanism that many view as integral to medicine's identity...
April 16, 2018: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29662759/investigation-of-bioeffects-of-g-protein-coupled-receptor-1-on-bone-turnover-in-male-mice
#9
Jian Li, Liang Xiang, Xiaotong Jiang, Bin Teng, Yutao Sun, Guanlian Chen, Jie Chen, Jian V Zhang, Pei-Gen Ren
Maintenance of healthy bone quality and quantity requires a well-coordinated balance between bone formation by osteoblasts and bone resorption by osteoclasts. Chemerin is a novel adipokine with known functions such as regulating immunity and energy homeostasis through activation of chemokine-like receptor 1 (CMKLR1). G protein-coupled receptor 1 (GPR1) is the second mammalian chemerin receptor with similar binding affinity as CMKLR1. In male GPR1-/- mice, a phenotype with significantly low bone mineral density was observed...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29662685/adaptation-translation-and-reliability-of-the-australian-juniors-enjoying-cricket-safely-injury-risk-perception-questionnaire-for-sri-lanka
#10
Prasanna J Gamage, Lauren V Fortington, Caroline F Finch
Objectives: Cricket is a very popular sport in Sri Lanka. In this setting there has been limited research; specifically, there is little knowledge of cricket injuries. To support future research possibilities, the aim of this study was to cross-culturally adapt, translate and test the reliability of an Australian-developed questionnaire for the Sri Lankan context. Methods: The Australian 'Juniors Enjoying Cricket Safely' (JECS-Aus) injury risk perception questionnaire was cross-culturally adapted to suit the Sri Lankan context and subsequently translated into the two main languages (Sinhala and Tamil) based on standard forward-back translation...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29662017/use-of-unpalatable-forages-by-ruminants-the-influence-of-experience-with-the-biophysical-and-social-environment
#11
REVIEW
Roberto A Distel, Juan J Villalba
Unpalatable forage resources (low nutrient density, potentially toxic metabolites) are widespread and represent a challenge for ruminant nutrition, health, and welfare. Our objective was to synthesize the role of biophysical and social experience on the use of unpalatable forages by ruminants, and highlight derived behavioural solutions for the well-being of soils, plants, and animals. Environmental experiences early in life modulate gene expression and promote learning, which alters morpho-physiological and psychological mechanisms that modify behavioural responses and change food and habitat selection...
April 14, 2018: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29661749/a-website-supporting-sensitive-religious-and-cultural-advance-care-planning-acptalk-formative-and-summative-evaluation
#12
Amanda Pereira-Salgado, Patrick Mader, Clare O'Callaghan, Leanne Boyd
BACKGROUND: Advance care planning (ACP) promotes conversations about future health care needs, enacted if a person is incapable of making decisions at end-of-life that may be communicated through written documentation such as advance care directives. To meet the needs of multicultural and multifaith populations in Australia, an advance care planning website, ACPTalk, was funded to support health professionals in conducting conversations within diverse religious and cultural populations...
April 16, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29661609/assessing-the-effect-of-an-educational-intervention-on-nurses-and-patient-care-assistants-comprehension-and-documentation-of-functional-ability-in-pediatric-patients-with-sickle-cell-disease
#13
Katherine M Bernier, Megan Strobel, Ruth Lucas
PURPOSE: In 2014, the Youth Acute Pain Functional Ability Questionnaire (YAPFAQ) was developed to investigate patient's self-rated functional ability during times of acute pain in the inpatient clinical setting. Although it has great potential, the application of this tool has not been made a standard of care. The purpose of this multiple methods study was to determine if, through an educational intervention, hospital staff could consistently document the YAPFAQ in children with sickle cell disease (SCD) during a vaso-occlusive episode...
April 13, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29661002/female-gynecologists-and-their-birth-control-clinics-eugenics-in-practice-in-1920s-1930s-china
#14
Mirela David
Yang Chao Buwei, the first Chinese translator of Margaret Sanger's What Every Girl Should Know, was the first female gynecologist to open up a birth control clinic in China. By the 1930s, other female gynecologists, like Guo Taihua, had internalized and combined national and eugenic concerns of race regeneration to focus on the control of women's reproduction. This symbiosis between racial regeneration and birth control is best seen in Yang Chongrui's integration of birth control into her national hygiene program...
April 16, 2018: Canadian Bulletin of Medical History, Bulletin Canadien D'histoire de la Médecine
https://www.readbyqxmd.com/read/29660481/scoping-review-identifies-significant-number-of-knowledge-translation-theories-models-and-frameworks-with-limited-use
#15
REVIEW
Lisa Strifler, Roberta Cardoso, Jessie McGowan, Elise Cogo, Vera Nincic, Paul A Khan, Alistair Scott, Marco Ghassemi, Heather MacDonald, Yonda Lai, Victoria Treister, Andrea C Tricco, Sharon E Straus
OBJECTIVE: To conduct a scoping review of knowledge translation (KT) theories, models and frameworks that have been used to guide dissemination or implementation of evidence-based interventions targeted to prevention and/or management of cancer or other chronic diseases. STUDY DESIGN AND SETTING: We used a comprehensive multistage search process from 2000-2016, which included traditional bibliographic database searching, searching using names of theories, models and frameworks, and cited reference searching...
April 13, 2018: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29660181/descriptive-versus-mechanistic-scientific-approach-to-study-wound-healing-and-its-inhibition-is-there-a-value-of-translational-research-involving-human-subjects
#16
REVIEW
Irena Pastar, Lulu Lu Wong, Andjela N Egger, Marjana Tomic-Canic
The clinical field of wound healing is challenged by numerous hurdles. Not only are wound healing disorders complex and multifactorial, but the corresponding patient population is diverse, often elderly and burdened by multiple comorbidities such as diabetes, cardiovascular disease, etc. The care of such patients requires a dedicated, multi-disciplinary team of physicians, surgeons, nurses, and scientists. In spite of the critical clinical need, it has been over 15 years since a treatment received approval for efficacy by the FDA in the United States...
April 16, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29659694/nutritional-genomics-and-direct-to-consumer-genetic-testing-an-overview
#17
Marta Guasch-Ferré, Hassan S Dashti, Jordi Merino
The increasing prevalence in polygenic diseases, such as obesity, cardiovascular disease, and type 2 diabetes, observed over the past few decades is more likely linked to a rapid transition in lifestyle rather than to changes in the sequence of the nuclear genome. In the new era of precision medicine, nutritional genomics holds the promise to be translated into tailored nutritional strategies to prevent and manage polygenic diseases more effectively. Nutritional genomics aims to prevent, treat, and manage polygenic diseases through targeted therapies formulated from individuals' genetic makeup and dietary intake...
March 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29659311/a-knowledge-translation-intervention-designed-using-audit-and-feedback-and-the-theoretical-domains-framework-for-physical-therapists-working-in-inpatient-rehabilitation-a-case-report
#18
Wendy Romney, Nancy Salbach, James Scott Parrott, Judith E Deutsch
BACKGROUND AND PURPOSE: Little is known about the process of engaging key stakeholders to select and design a knowledge translation (KT) intervention to increase the use of an outcome measure using audit and feedback. The purpose of this case report was to describe the development of a KT intervention designed with organizational support to increase physical therapists' (PTs) use of a selected outcome measure in an inpatient sub-acute rehabilitation hospital. CASE DESCRIPTION: Eleven PTs who worked at a sub-acute rehabilitation hospital participated...
April 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29658978/innovation-and-entrepreneurship-perspectives-from-orthopedic-surgery
#19
Kevin J Campbell, Philip K Louie, Derek A Khorsand, Nicholas B Frisch, Tad L Gerlinger, Brett R Levine
Orthopedic surgeons are tasked with treating complex patients while employing critical surgical skills, clinical knowledge, and new technologies. The constant inundation of information, coupled with hours in the hospital setting, provides unique perspectives on various aspects of how health care is delivered, thereby creating a milieu ripe for innovation. The rigors of an orthopedic career make it challenging for physicians to translate an idea into a great product. Through the authors' experiences at a tertiary orthopedic practice, they review the process of taking an idea from concept to fruition...
April 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29657853/training-scientists-as-future-industry-leaders-teaching-translational-science-from-an-industry-executive-s-perspective
#20
Gloria Lee, Jay D Kranzler, Ravichandran Ramasamy, Gabrielle Gold-von Simson
PhDs and post-doctoral biomedical graduates, in greater numbers, are choosing industry based careers. However, most scientists do not have formal training in business strategies and venture creation and may find senior management positions untenable. To fill this training gap, "Biotechnology Industry: Structure and Strategy" was offered at New York University School of Medicine (NYUSOM). The course focuses on the business aspects of translational medicine and research translation and incorporates the practice of business case discussions, mock negotiation, and direct interactions into the didactic...
2018: Journal of Translational Science
keyword
keyword
8895
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"