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https://www.readbyqxmd.com/read/29056980/youth-mental-health-family-practice-and-knowledge-translation-video-games-about-psychosis-family-physicians-perspectives
#1
Manuela Ferrari, Archie Suzanne
OBJECTIVE: Family practitioners face many challenges providing mental healthcare to youth. Digital technology may offer solutions, but the products often need to be adapted for primary care. This study reports on family physicians' perspectives on the relevance and feasibility of a digital knowledge translation (KT) tool, a set of video games, designed to raise awareness about psychosis, marijuana use, and facilitate access to mental health services among youth. METHOD: As part of an integrated knowledge translation project, five family physicians from a family health team participated in a focus group...
2017: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/29056625/the-development-of-a-community-engagement-workshop-a-community-led-approach-for-building-researcher-capacity
#2
Jake Coffey, Anna Huff-Davis, Christie Lindsey, Onie Norman, Henryetter Curtis, Calvin Criner, M Kathryn Stewart
BACKGROUND: Although community-engaged research (CEnR) is increasingly promoted in the literature, academic programs often fail to prepare researchers for the critical, ethical, and power issues involved in CEnR. This article documents a community-created and led workshop for CEnR researchers. OBJECTIVES: The workshop's main objective is to increase researchers' knowledge and felt experience of the "dos and don'ts" of CEnR in three research domains: entering the community, accommodating the realities and constraints of community-based organizations, and dissemination...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29056126/review-typology-the-basic-types-of-reviews-for-synthesizing-evidence-for-the-purpose-of-knowledge-translation
#3
Sunil Sadruddin Samnani, Marcus Vaska, Salim Ahmed, Tanvir C Turin
With advances in medical practice and fields of research, reviews occupy a key position for summarizing existing knowledge. Due to the differences and overlap in terminology, the full potential for reviews may be lost due to confusion of indistinct approaches. The main objective of this study was to provide a descriptive outline of each of the common review types with their characteristics and examples in a health care system. Ascoping search was conducted using the keywords associated with the literature review typology...
October 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29054357/stem-cells-and-heart-disease-brake-or-accelerator
#4
Gustav Steinhoff, Julia Nesteruk, Markus Wolfien, Jana Große, Ulrike Ruch, Praveen Vasudevan, Paula Müller
After two decades of intensive research and attempts of clinical translation, stem cell based therapies for cardiac diseases are not getting closer to clinical success. This review tries to unravel the obstacles and focuses on underlying mechanisms as the target for regenerative therapies. At present, the principal outcome in clinical therapy does not reflect experimental evidence. It seems that the scientific obstacle is a lack of integration of knowledge from tissue repair and disease mechanisms. Recent insights from clinical trials delineate mechanisms of stem cell dysfunction and gene defects in repair mechanisms as cause of atherosclerosis and heart disease...
October 17, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29053143/momp-cell-suicide-as-a-bcl-2-family-business
#5
REVIEW
Halime Kalkavan, Douglas R Green
Apoptosis shapes development and differentiation, has a key role in tissue homeostasis, and is deregulated in cancer. In most cases, successful apoptosis is triggered by mitochondrial outer membrane permeabilization (MOMP), which defines the mitochondrial or intrinsic pathway and ultimately leads to caspase activation and protein substrate cleavage. The mitochondrial apoptotic pathway centered on MOMP is controlled by an intricate network of events that determine the balance of the cell fate choice between survival and death...
October 20, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29050514/modelling-self-assessed-vulnerability-to-hiv-and-its-associated-factors-in-a-hiv-burdened-country
#6
A F Fagbamigbe, A M Lawal, E S Idemudia
BACKGROUND: Globally, individuals' self-assessment of vulnerability to HIV infection is important to maintain safer sexual behaviour and reduce risky behaviours. However, determinants of self-perceived risk of HIV infection are not well documented and differ. We assessed the level of self-perceived vulnerability to HIV infection in Nigeria and also identified its risk factors. METHODS: We explored a recent nationally representative data with self-reported vulnerability ('high', 'low' and 'no risk at all') to HIV infection as the outcome of interest...
December 2017: SAHARA J: Journal of Social Aspects of HIV/AIDS Research Alliance
https://www.readbyqxmd.com/read/29049930/antibiotic-efficacy-context-matters
#7
REVIEW
Jason H Yang, Sarah C Bening, James J Collins
Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each contribute to antibiotic-induced cell death. Moreover, environmental factors such as oxygen availability, extracellular metabolites, population heterogeneity and multidrug contexts alter antibiotic efficacy by impacting bacterial metabolism and stress responses...
October 16, 2017: Current Opinion in Microbiology
https://www.readbyqxmd.com/read/29049353/should-preventive-antibiotics-be-used-in-patients-with-acute-stroke-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#8
Feng Zheng, Niklas von Spreckelsen, Xintong Zhang, Pantelis Stavrinou, Marco Timmer, Christian Dohmen, Roland Goldbrunner, Fang Cao, Qiang Zhang, Qishan Ran, Gang Li, Ruiming Fan, Shengtao Yao, Boris Krischek
BACKGROUND: Infection is a common complication in acute stroke. Whether or not preventive antibiotics reduce the risk of infection or even lead to a favorable outcome and reduction of mortality after a stroke still remains equivocal. This review was performed to update the current knowledge on the effect and possible benefits of prophylactic antibiotic therapy in patients with stroke. METHODS: A systematic review and meta-analysis of preventive antibiotics`effect on the incidence of infection, favorable outcome (mRS≤2) and mortality in patients with acute stroke is performed with relevant randomized controlled trials...
2017: PloS One
https://www.readbyqxmd.com/read/29048929/the-effect-of-hamstring-tendon-autograft-harvest-on-the-restoration-of-knee-stability-in-the-setting-of-concurrent-anterior-cruciate-ligament-and-medial-collateral-ligament-injuries
#9
Thomas J Kremen, Landon S Polakof, Sean S Rajaee, Trevor J Nelson, Melodie F Metzger
BACKGROUND: A hamstring autograft is commonly used in anterior cruciate ligament (ACL) reconstruction (ACLR); however, there is evidence to suggest that the tendons harvested may contribute to medial knee instability. HYPOTHESIS: We tested the hypothesis that the gracilis (G) and semitendinosus (ST) tendons significantly contribute to sagittal, coronal, and/or rotational knee stability in the setting of ACLR with a concurrent partial medial collateral ligament (MCL) injury...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29045622/international-exchanges-in-primary-care-learning-from-thy-neighbour
#10
Bernadeta Bridgwood, John Park, Claire Hawcroft, Natasha Kay, Eugene Tang
This systematic review describes how international exchange programmes in primary care have been received and evaluated. Electronic databases (MEDLINE, Embase, PsycINFO, EBM reviews, CAB abstracts and PubMED) were searched to identify articles where the main focus of the study was exchanges undertaken in primary care/family medicine until March 2016. Articles were included if they (i) discussed participant exchanges in primary care; (ii) presented associated outcome data-this included (a) individual/group experience of exchange; (b) mechanism of exchange and (c) observations during the exchange...
October 14, 2017: Family Practice
https://www.readbyqxmd.com/read/29044650/knowledge-translation-in-occupational-therapy
#11
EDITORIAL
Sally Bennett
No abstract text is available yet for this article.
October 2017: Australian Occupational Therapy Journal
https://www.readbyqxmd.com/read/29044409/improving-pain-care-with-project-echo-in-community-health-centers
#12
Daren Anderson, Ianita Zlateva, Bennet Davis, Lauren Bifulco, Tierney Giannotti, Emil Coman, Douglas Spegman
Objective: Pain is an extremely common complaint in primary care, and patient outcomes are often suboptimal. This project evaluated the impact of Project ECHO Pain videoconference case-based learning sessions on knowledge and quality of pain care in two Federally Qualified Health Centers. Design: Quasi-experimental, pre-post intervention, with comparison group. Setting: Two large, multisite federally qualified health centers in Connecticut and Arizona...
October 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29044368/use-of-bayesian-networks-in-predicting-contamination-of-drinking-water-with-e-coli-in-rural-vietnam
#13
David C Hall, Quynh B Le
Background: More than 70 million Vietnamese rely on small-scale farming for some form of household income. Water on many of those farms is contaminated with waste, including animal manure, partly due to non-sustainable waste management. This increases the risk of water-related zoonotic disease transmission. The purpose of this research was to examine the impact of various demographic and management factors on the likelihood of finding Escherichia coli in drinking water sourced from wells and rainwater on farms in Vietnam...
June 1, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29042387/nature-based-care-opportunities-and-barriers-in-oncology-contexts-a-modified-international-e-delphi-survey
#14
Sarah Blaschke, Clare C O'Callaghan, Penelope Schofield
OBJECTIVE: To develop recommendations regarding opportunities and barriers for nature-based care in oncology contexts using a structured knowledge generation process involving relevant healthcare and design experts. DESIGN: Four-round modified electronic Delphi study. Oncology patients' nature-based recommendations, uncovered in preceding qualitative investigation, were included in the first round for the expert participants' consideration. Key items (opportunities and barriers) were developed using data aggregation and synthesis, followed by item prioritisation and 10-point Likert scale ranking (1=not important, 10=very important)...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29042191/roadmap-to-achieve-25-hypertension-control-in-africa-by-2025
#15
Anastase Dzudie, Brian Rayner, Dike Ojji, Aletta E Schutte, Marc Twagirumukiza, Albertino Damasceno, Seringe Abdou Ba, Abdoul Kane, Euloge Kramoh, Jean Baptiste Anzouan Kacou, Basden Onwubere, Ruth Cornick, Karen Sliwa, Benedict Anisiuba, Ana Olga Mocumbi, Elijah Ogola, Mohamed Awad, George Nel, Harun Otieno, Ali Ibrahim Toure, Samuel Kingue, Andre Pascal Kengne, Pablo Perel, Alma Adler, Neil Poulter, Bongani Mayosi
BACKGROUND: The Pan-African Society of Cardiology (PASCAR) has identified hypertension as the highest area of priority action to reduce heart disease and stroke on the continent. OBJECTIVES: The aim of this PASCAR roadmap on hypertension was to develop practical guidance on how to implement strategies that translate existing knowledge into effective action and improve detection, treatment and control of hypertension and cardiovascular health in sub-Saharan Africa (SSA) by the year 2025...
October 14, 2017: Global Heart
https://www.readbyqxmd.com/read/29041800/an-exploration-of-the-knowledge-attitudes-and-beliefs-of-xhosa-men-concerning-traditional-circumcision
#16
Salome Froneman, Paul A Kapp
BACKGROUND: The practice of traditional circumcision is associated with considerable morbidity and mortality, yet there is a paucity of literature that provides an understanding of the cultural values that influence men to choose traditional rather than medical circumcision.The aim of this study was to better understand the culture surrounding traditional circumcision, with a view to addressing morbidity and mortality rates associated with the Xhosa male initiation rituals.We explored Xhosa men's perceptions regarding the need for the risks and the social pressure to undergo traditional circumcision, the impact of non-initiation or failed initiation and the perceived barriers to obtaining medical help for the complications of traditional circumcisions...
October 13, 2017: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29040388/rna-structure-interactions-and-ribonucleoprotein-processes-of-the-influenza-a-virus
#17
Wayne K Dawson, Michal Lazniewski, Dariusz Plewczynski
In one more years, we will 'celebrate' an exact centenary of the Spanish flu pandemic. With the rapid evolution of the influenza virus, the possibility of novel pandemic remains ever a concern. This review covers our current knowledge of the influenza A virus: on the role of RNA in translation, replication, what is known of the expressed proteins and the protein products generated from alternative splicing, and on the role of base pairing in RNA structure. We highlight the main events associated with viral entry into the cell, the transcription and replication process, an export of the viral genetic material from the nucleus and the final release of the virus...
October 10, 2017: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/29038612/dna-methylation-as-a-noninvasive-epigenetic-biomarker-for-the-detection-of-cancer
#18
REVIEW
Catherine Leygo, Marissa Williams, Hong Chuan Jin, Michael W Y Chan, Wai Kit Chu, Michael Grusch, Yuen Yee Cheng
In light of the high incidence and mortality rates of cancer, early and accurate diagnosis is an important priority for assigning optimal treatment for each individual with suspected illness. Biomarkers are crucial in the screening of patients with a high risk of developing cancer, diagnosing patients with suspicious tumours at the earliest possible stage, establishing an accurate prognosis, and predicting and monitoring the response to specific therapies. Epigenetic alterations are innovative biomarkers for cancer, due to their stability, frequency, and noninvasive accessibility in bodily fluids...
2017: Disease Markers
https://www.readbyqxmd.com/read/29038335/preclinical-and-coclinical-studies-in-prostate-cancer
#19
Ming Chen, Pier Paolo Pandolfi
Men who develop metastatic castration-resistant prostate cancer (mCRPC) will invariably succumb to their disease. Thus there remains a pressing need for preclinical testing of new drugs and drug combinations for late-stage prostate cancer (PCa). Insights from the mCRPC genomic landscape have revealed that, in addition to sustained androgen receptor (AR) signaling, there are other actionable molecular alterations and distinct molecular subclasses of PCa; however, the rate at which this knowledge translates into patient care via current preclinical testing is painfully slow and inefficient...
October 16, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29037484/australian-midwives-views-and-experiences-of-practice-and-politics-related-to-water-immersion-for-labour-and-birth-a-web-based-survey
#20
Megan Cooper, Jane Warland, Helen McCutcheon
BACKGROUND: There is little published research that has examined practitioners' views and experiences of pain relieving measures commonly used during labour and birth, particularly for non-pharmacological measures such as water immersion. Furthermore, there is minimal published research examining the process of policy and guideline development, that is, the translation of published research to usable practice guidance. AIMS: The aims of phase three of a larger study were to explore midwives knowledge, experiences and support for the option of water immersion for labour and birth in practice and their involvement, if any, in development of policy and guidelines pertaining to the option...
October 13, 2017: Women and Birth: Journal of the Australian College of Midwives
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