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https://www.readbyqxmd.com/read/28548971/allergic-contact-dermatitis-in-preservatives-current-standing-and-future-options
#1
Gustavo Deza, Ana M Giménez-Arnau
PURPOSE OF REVIEW: Preservatives are well known skin sensitizers and represent one of the main causes of contact allergy. The purpose of this article is to review the current state of contact sensitization induced by preservatives and point future alternatives for products' preservation. RECENT FINDINGS: Isothiazolinones currently are the most common preservatives responsible of contact allergy in Europe and in the United States, and although some regulatory interventions have been taken place, the current contact allergy outbreak is not yet under control...
May 25, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28538006/evaluation-and-management-of-patch-test-negative-patients-with-generalized-dermatitis
#2
Alison Spiker, Christen M Mowad
BACKGROUND: Patients with generalized dermatitis are common in dermatology practices. Allergic contact dermatitis is often suspected, and patients frequently undergo patch testing. When patch testing result is negative, further evaluation and management of these patients are challenging. OBJECTIVE: The purpose of this study was to survey members of the American Contact Dermatitis Society regarding the evaluation and management of patch test-negative patients with generalized dermatitis...
May 23, 2017: Dermatitis
https://www.readbyqxmd.com/read/28530059/-chronic-dermatitis-of-the-dorsum-of-the-feet-and-shins-due-to-allergic-contact-dermatitis-to-leather-products
#3
Liran Horev
A 40 year old woman presented with dermatitis mainly involving her dorsal feet and shins, a condition which was present for a prolonged period of time. The distribution was suggestive of allergic contact dermatitis, possibly to her shoes. Patch tests disclosed allergy to chromates, cobalt, colophony, all present in leather products, and allergy to myroxylon pereirae (Balsam of Peru). The patient was instructed to avoid wearing some of her shoes and sitting on her leather sofa. As a consequence, her symptoms ameliorated...
October 2016: Harefuah
https://www.readbyqxmd.com/read/28524256/quantification-of-l-carvone-in-toothpastes-available-on-the-swedish-market
#4
Liv Kroona, Gunnar Warfvinge, Marléne Isaksson, Camilla Ahlgren, Jakob Dahlin, Östen Sörensen, Magnus Bruze
BACKGROUND: Toothpastes have widespread use in the population, and contain flavours used to give a pleasant and often minty aroma. Flavours are prevalent allergens in toothpastes, and adverse reactions often present as perioral dermatitis or stomatitis. l-Carvone, a mint flavour found in spearmint oil, is one of these allergens. There are few studies on contact allergy to l-carvone, and some of them have indicated a positive relationship with oral lichenoid lesions. OBJECTIVES: To qualitatively and quantitatively investigate the presence of l-carvone in commercially available toothpastes on the Swedish market...
May 19, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28523864/allergic-contact-dermatitis-due-to-methylisothiazolinone-in-a-young-girl-s-laundry-detergent
#5
Colleen H Cotton, Cliff G Duah, Catalina Matiz
Methylisothiazolinone (MI) is an emerging and increasing cause of allergic contact dermatitis (ACD) in children. We present the case of a 7-year-old girl with an unusual dermatitis suspicious for contact allergy. Patch testing confirmed allergy to MI, found only in the patient's laundry detergent. This case highlights the importance of checking household product ingredients and the role of MI as an increasing cause of ACD in children.
May 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28516256/-skin-diseases-associated-with-environmental-factors
#6
REVIEW
Vera Mahler
BACKGROUND: Multiple environmental exposures may derange the regulatory and repair mechanisms of the skin and lead to dermatological disease. OBJECTIVES: Provide an overview of non-allergic skin diseases associated with environmental factors. MATERIALS AND METHODS: Review of current scientific evidence for associations of non-allergic skin diseases with environmental exposures: irritation, chemicals, infection, UV-radiation, temperature. RESULTS: Predisposition (constitution e...
May 17, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28511194/brushing-your-way-to-allergic-contact-dermatitis-anethole-allergy
#7
Kelly A Aschenbeck, Sara A Hylwa
No abstract text is available yet for this article.
May 2017: Dermatitis
https://www.readbyqxmd.com/read/28509716/multicenter-patch-testing-with-methylchloroisothizoline-methylisothiazolinone-in-100-and-200-ppm-within-the-international-contact-dermatitis-research-group
#8
Malin Engfeldt, Iris Ale, Klaus E Andersen, Peter Elsner, Chee-Leok Goh, An Goossens, Hemangi Jerajani, Kayoko Matsunaga, Magnus Bruze
BACKGROUND: The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known contact sensitizer. Historically, there have been different opinions on the optimal patch test concentration of MCI/MI, and both 0.01% and 0.02% aqueous (aq.) have been proposed. In 2011, based on literature reviews, it was recommended that the concentration of 0.02% aq. should be used in the international baseline series. OBJECTIVES: The aim of this study was to verify the recommendation from 2011 by comparing the patch test results from consecutive patch testing with MCI/MI 0...
May 2017: Dermatitis
https://www.readbyqxmd.com/read/28509715/epidemic-of-isothiazolinone-allergy-in-north-america-prevalence-data-from-the-north-american-contact-dermatitis-group-2013-2014
#9
Matthew J Zirwas, Dathan Hamann, Erin M Warshaw, Howard I Maibach, James S Taylor, Denis Sasseville, Joel G DeKoven, Anthony F Fransway, C G Toby Mathias, Kathryn A Zug, Vincent A DeLeo, Joseph F Fowler, James G Marks, Melanie D Pratt, Donald V Belsito
BACKGROUND: Preservative sensitivity patterns evolve with changing use patterns in products. During the last decade, the use of methylisothiazolinone (MI) at higher concentrations in both leave-on and rinse-off products has significantly increased. This is the first North American Contact Dermatitis Group reporting cycle that includes both methylchloroisothiazolinone (MCI)/MI and MI data. OBJECTIVE: The aim of this study was to report the prevalence of isothiazolinone allergy (MCI/MI and MI) in the North American Contact Dermatitis Group patch-test population from January 1, 2013, to December 31, 2014...
May 2017: Dermatitis
https://www.readbyqxmd.com/read/28508257/diagnosing-allergic-contact-dermatitis-through-elimination-perception-detection-and-deduction
#10
REVIEW
Korbkarn Pongpairoj, Pailin Puangpet, Supitchaya Thaiwat, John P McFadden
Several authors have commented upon the skills of detection required in making a diagnosis of allergic contact dermatitis. Here, we emphasise the search for clues in a systematic manner. We describe four stages as part of a systematic method for diagnosing allergic contact dermatitis. Firstly, elimination (or inclusion) of non-allergic diagnoses. Secondly, perception: the pre-patch test diagnosis and the 'three scenarios' principle. Thirdly, detection: optimising the sensitivity of the patch test process. Fourthly, deduction: diagnosing allergic contact dermatitis by associating the dermatitis with the allergen exposure...
May 15, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28472426/chemical-or-drug-hypersensitivity-is-the-immune-system-clearing-the-danger
#11
Marc Pallardy, Rami Bechara
Hypersensitivity reaction or allergy, initially perceived as a secondary disorder, is now believed to be a major public health. For instance, contact dermatitis is a type IV delayed-type hypersensitivity reaction to skin allergens. An estimated 15-20% of the general population has acquired contact allergy. To maintain immune tolerance our immune system need to differentiate between harmful non-self and innocuous non-self. Living organisms have developed during their evolution a set of biological mechanisms to protect them from the "outside": physical barrier, inflammation, cell-based mechanisms, metabolism and elimination and biochemical pathways such as glutathione...
May 4, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28470762/contact-allergy-in-children-with-atopic-dermatitis-a-systematic-review
#12
REVIEW
A B Simonsen, J D Johansen, M Deleuran, C G Mørtz, M Sommerlund
The importance of contact allergy in children with atopic dermatitis is frequently debated. Previously, patients with atopic dermatitis were believed to have a reduced ability to produce a type IV immunologic response. However, this belief has been challenged and authors have highlighted the risk of underestimating and overlooking allergic contact dermatitis in children with atopic dermatitis. Several studies have been published aiming to shed light on this important question but results are contradictory. To provide an overview of the existing knowledge, we systematically reviewed studies that report frequencies of positive patch test reactions in children with atopic dermatitis...
May 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28469764/re-international-survey-on-skin-patch-test-procedures-attitudes-and-interpretation-l-k-tanno-et-al-waoj-2016-9-8
#13
Wolfgang Uter, Magnus Bruze, Thomas Rustemeyer, David Orton, Vera Mahler
A previous survey on the practice of diagnostic patch testing among representatives of member societies of the World Allergy Organization (WAO) has, in some countries, not addressed those stakeholders actually involved in patch testing, mainly dermatologists. The need for further standardisation is acknowledged and has been addressed e.g. by publication of a patch test guideline by the European Society of Contact Dermatitis in October 2015.
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28449346/airborne-allergic-contact-dermatitis-caused-by-isothiazolinones-in-water-based-paints-a-retrospective-study-of-44-cases
#14
Emmanuelle Amsler, Olivier Aerts, Nadia Raison-Peyron, Michèle Debons, Brigitte Milpied, Françoise Giordano-Labadie, Julie Waton, Marie C Ferrier-Le Bouëdec, Isabelle Lartigau, Catherine Pecquet, Haudrey Assier, Martine Avenel-Audran, Claire Bernier, Florence Castelain, Evelyne Collet, Marie-Noëlle Crépy, Nathalie Genillier, Pascal Girardin, Pauline Pralong, Florence Tetart, Dominique Vital-Durand, Angele Soria, Annick Barbaud
BACKGROUND: Airborne allergic contact dermatitis caused by paints containing isothiazolinones has been recognized as a health hazard. OBJECTIVES: To collect epidemiological, clinical and patch test data on airborne allergic contact dermatitis caused by isothiazolinone-containing paints in France and Belgium. METHODS: A descriptive, retrospective study was initiated by the Dermatology and Allergy Group of the French Society of Dermatology, including methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI)- and/or MI-sensitized patients who developed airborne allergic contact dermatitis following exposure to isothiazolinone-containing paint...
April 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28425114/a-multi-institutional-joint-study-of-contact-dermatitis-related-to-hair-colouring-and-perming-agents-in-japan
#15
Akiko Ito, Kazue Nishioka, Hiromi Kanto, Akiko Yagami, Shigeki Yamada, Mariko Sugiura, Chihiro Yasunaga, Keiko Yoshii, Hiromi Kobayashi, Atsuko Adachi, Yuko Ikezawa, Kumiko Washizaki, Shigeki Inui, Hitoshi Miyazawa, Naoki Oiso, Tokio Nakata, Kayoko Matsunaga
BACKGROUND: In Japan, allergic contact dermatitis caused by hair colouring agents is a considerable problem for those occupationally exposed and also for consumers. Over the last 20 years, p-phenylenediamine (PPD) has been a common allergen, with ∼7% positive patch test reactions. OBJECTIVES: To investigate which ingredients caused allergic contact dermatitis related to hair dye and perming solutions in Japan, to assess whether PPD is suitable for screening for hair dye allergy, and to propose allergens for a Japanese hairdresser series...
April 20, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28421670/an-epidemic-of-allergic-contact-dermatitis-caused-by-a-new-allergen-caprylhydroxamic-acid-in-moisturizers
#16
Leena Ackermann, Hannele Virtanen, Laura Korhonen, Arja Laukkanen, Laura Huilaja, Riitta Riekki, Taina Hasan
BACKGROUND: In 2016, dermatologists in Finland suspected contact allergy in several patients using moisturizers under the trade name Apobase®. Following a formulation change, Phenostat™, which is a mixture of phenoxyethanol, caprylhydroxamic acid, and methylpropanediol, was used as a preservative in Apobase® moisturizers in Finland. OBJECTIVES: To confirm the suspected contact allergy to Apobase® cream, oily cream, and/or lotion, and to identify the specific contact allergen and define its optimal patch test concentration...
April 19, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28416298/-epicutaneous-patch-testing-in-delayed-drug-hypersensitivity-reactions-induced-by-antiepileptic-drugs
#17
Lobna Ben Mahmoud, Najla Bahloul, Hanen Ghozzi, Brahim Kammoun, Ahmed Hakim, Zouheir Sahnoun, Sami Kammoun, Khaled Zeghal
INTRODUCTION: Antiepileptic drugs are widely used and are associated with numerous side effects including skin eruptions. Epicutaneous tests have been used with variable success in skin drug reactions. The purpose of this study was to evaluate the profitability of epicutaneous tests in delayed hypersensitivity reactions induced by antiepileptic drugs. METHODS: We analyzed all cases of allergic skin reactions to antiepileptic drugs notified in regional pharmacovigilance center of Sfax (Tunisia) between June 1, 2014 and April 30, 2016...
March 25, 2017: Thérapie
https://www.readbyqxmd.com/read/28401153/metals-are-important-contact-sensitizers-an-experience-from-lithuania
#18
Kotryna Linauskienė, Laura Malinauskienė, Audra Blažienė
Background. Metals are very frequent sensitizers causing contact allergy and allergic contact dermatitis worldwide; up-to-date data based on patch test results has proved useful for the identification of a problem. Objectives. In this retrospective study prevalence of contact allergy to metals (nickel, chromium, palladium, gold, cobalt, and titanium) in Lithuania is analysed. Patients/Methods. Clinical and patch test data of 546 patients patch tested in 2014-2016, in Vilnius University Hospital Santariskiu Klinikos, was analysed and compared with previously published data...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28396898/-allergic-contact-dermatitis-of-the-scalp
#19
REVIEW
L Koch, W Aberer
Contact allergy represents an important differential diagnosis to other skin diseases of the scalp. The typical efflorescences, spreading in the periphery, pruritus, and the clinical history support the differential diagnosis. Since the scalp is particularly resistant to contact dermatitis, allergens applied to this area often produce dermatitis of the eyelids, ears and neck. Nevertheless, potent allergens such as para-phenylendiamine can also cause severe reactions of the scalp. The most important allergens eliciting contact allergy of the scalp are found in bleaches and dyes, shampoos and conditioners, products for perm waves and straighteners as well as topical drugs...
April 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28396866/survey-of-occupational-allergic-contact-dermatitis-and-patch-test-among-clothing-employees-in-beijing
#20
Yu-Xin Chen, Bing-Ai Gao, Hai-Yan Cheng, Lin-Feng Li
Occupational population-based epidemiological data relating to occupational contact allergies in the Chinese clothing industry are limited. To investigate the prevalence of occupational allergic contact dermatitis (OACD) and to identify the causative allergens among clothing employees in China, a cross-sectional study was conducted in 529 clothing employees at 12 clothing factories in Beijing. All employees were subjected to an interview using self-administered questionnaire and skin examination, and those who were diagnosed with occupational contact dermatitis (OCD) were patch tested...
2017: BioMed Research International
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