Hironobu Ishimaru, Kenta Nakamoto, Mariko Yamane, Takenobu Yamamoto, Keisuke Kitakaze, Yasuhiro Takenouchi, Kazuhito Tsuboi, Yasuo Okamoto, Yumi Aoyama
Although subtle barrier defects may facilitate allergen penetration, thereby enabling allergic sensitization, the relationship between sweating disturbance and skin barrier function is unknown. However, many studies on contact hypersensitivity in mice examined ear skin, which does not sweat, instead of the footpad, where sweating is uniquely present. Here, we assessed whether sweat suppression in the footpad before hapten application provoked a skin barrier abnormality and reduced inflammatory thresholds to topical haptens...
March 22, 2024: Journal of Investigative Dermatology