keyword
https://read.qxmd.com/read/38378755/long-term-complications-and-outcomes-of-augmentation-cystoplasty-in-children-with-neurogenic-bladder
#21
JOURNAL ARTICLE
Jei-Wen Chang, Fang-Cheng Kuo, Tzu-Ching Lin, Tai-Wai Chin, Ling-Yu Yang, Hsin-Hung Chen, Yu-Hua Fan, Hui-Hsin Yang, Chin-Su Liu, Hsin-Lin Tsai
Augmentation cystoplasty (AC) is an effective surgical procedure for patients with neurogenic bladder whenever conservative treatments have failed. The present study aimed to determine the risks of metabolic complications, malignancy, long-term outcomes and histopathologic changes of native bladder and the augmented intestine after AC in children with neurogenic bladder. Pediatric patients < 18 years who underwent AC between 2000 and 2020 were enrolled. Early postoperative complications, long-term outcomes and histopathologic changes in mucosal biopsies of native bladder and the augmented intestine after AC were reviewed...
February 20, 2024: Scientific Reports
https://read.qxmd.com/read/38376662/acoustic-emission-of-kidney-stones-a-medical-adaptation-of-statistical-breakdown-mechanisms
#22
JOURNAL ARTICLE
Jack T Eckstein, Oliver J Wiseman, Michael A Carpenter, Ekhard K H Salje
Kidney stones have a prevalence rate of > 10% in some countries. There has been a significant increase in surgery to treat kidney stones over the last 10 years, and it is crucial that such techniques are as effective as possible, while limiting complications. A selection of kidney stones with different chemical and structural properties were subjected to compression. Under compression, they emit acoustic signals called crackling noise. The variability of the crackling noise was surprisingly great comparing weddellite, cystine and uric acid stones...
February 20, 2024: Urolithiasis
https://read.qxmd.com/read/38376588/molecular-mechanism-of-rhizoma-polygonati-in-the-treatment-of-nephrolithiasis-network-pharmacology-analysis-and-in-vivo-experimental-verification
#23
JOURNAL ARTICLE
Yuexian Xu, Hu Liang, Xike Mao, Yang Chen, Bingbing Hou, Zongyao Hao
Rhizoma Polygonati (RP) is the dried rhizome of the liliaceous plant. It has anti-inflammatory and anti-apoptosis effects. But its role in kidney stones has not been studied. The purpose of this study was to verify the effect of RP in the treatment of nephrolithiasis through network pharmacological analysis and in vivo experiments. The active compounds and protein targets of RP, as well as the potential targets of the nephrolithiasis were searched from the database. The protein-protein interaction (PPI) network diagram and the drug-compounds-targets-disease network were constructed...
February 20, 2024: Urolithiasis
https://read.qxmd.com/read/38362039/the-anti-urolithiatic-effect-of-the-roots-of-saussurea-costus-falc-lipsch-agonist-ethylene-glycol-and-magnesium-oxide-induced-urolithiasis-in-rats
#24
JOURNAL ARTICLE
Naima Mammate, Fatima Ezzahra El Oumari, Hamada Imtara, Salim Belchkar, Ramzi A Mothana, Hinde E L Fatemi, Mohammed Danouche, Sara Er-Rahmani, Nabil Boucetta, Omar M Noman, Mahmoud Tarayrah, Tarik Sqalli Houssaini
Phytotherapy, which involves the use of plant extracts and natural compounds for medicinal purposes, is indeed a promising alternative for managing urinary lithiasis. Many plants have been studied for their potential to prevent and treat kidney stones, and they may offer a more natural and potentially less harmful approach compared to conventional treatments. Additionally, phytotherapy may be more cost-effective. The aim of the present study was to investigate the antilithic potential of extracts and essential oils of Saussurea costus (Falc) Lipsch in two in vivo models, one on ethylene glycol-induced calcium oxalate crystal formation and the other to assess the effects of these extracts on magnesium oxide-induced struvite crystal formation...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38345349/naringenin-s-effects-on-diuresis-and-prevention-of-urolithiasis-in-hypertensive-rats
#25
JOURNAL ARTICLE
Rita de Cássia Vilhena da Silva, Anelize Dada, Sabrina Lucietti Dick, Martina Odebrecht Cavichiolo, Mariana Zanovello, Valdir Cechinel Filho, Priscila de Souza
This research demonstrates the diuretic effect of naringenin, a flavanone aglycone found in citrus, on spontaneously hypertensive female and male rats (SHR). The data reinforces existing literature findings that male SHR exhibits higher systolic blood pressure than age-matched females. Urine volume assessed over 8 hours was lower when obtained from SHR males than females. When these animals were orally treated with different doses of naringenin (0.1 - 1 mg/kg), this increased urinary volume in both genders at the highest dose tested...
February 12, 2024: Chemistry & Biodiversity
https://read.qxmd.com/read/38342873/association-between-klotho-gene-polymorphisms-and-urolithiasis-a-meta-analysis
#26
Jiaxuan Qin, Bo Duan, Bowen Chen, Jinchun Xing, Tao Wang
Former studies have suggested that urolithiasis is related to Klotho gene polymorphisms. The aim of this meta-analysis was to investigate this relationship. Studies on the association between urolithiasis susceptibility and Klotho gene polymorphisms were systematically searched for in databases. Odds ratios and 95% confidence intervals were pooled as the effect size. This meta-analysis incorporated ten articles. Klotho rs1207568 adenine (A) may be related to a decreased urolithiasis risk in Caucasians. The results showed that Klotho rs3752472 may not be related to urolithiasis risk in the Han Asian subgroup...
February 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://read.qxmd.com/read/38340263/prediction-of-spontaneous-distal-ureteral-stone-passage-using-artificial-intelligence
#27
JOURNAL ARTICLE
Tugay Aksakalli, Isil Karabey Aksakalli, Ahmet Emre Cinislioglu, Adem Utlu, Saban Oguz Demirdogen, Feyzullah Celik, Ibrahim Karabulut
PURPOSE: Identifying factors predicting the spontaneous passage of distal ureteral stones and evaluating the effectiveness of artificial intelligence in prediction. MATERIALS AND METHODS: The files of patients presenting with distal ureteral stones were retrospectively evaluated. Those who experienced spontaneous passage were assigned to Group P, while those who did not were assigned to Group N. Demographic and clinical data of both groups were compared. Then, logistic regression analysis was performed to determine the factors predicting spontaneous stone passage...
February 10, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38340151/multicentric-evaluation-of-high-and-low-power-lasers-on-rirs-success-using-propensity-score-analysis
#28
MULTICENTER STUDY
Eren Erol, Gokhan Ecer, Murat Can Kiremit, Mehmet İlker Gokce, Mehmet Balasar, Ahmet Furkan Sarikaya, Muammer Babayigit, Umut Can Karaarslan, Elif Ipek Aksoy, Kemal Sarica, Kamran Ahmed, Selçuk Güven
In this study, we aimed to evaluate the effect of HPL on different parameters by different centers and urologists. While doing this, we evaluated different parameters by comparing HPL(High Power laser) and LPL(Low-power laser). This is an observational, retrospective, comparative, multicentric study of prospectively organised database. A total of 217 patients who underwent RIRS for kidney stones smaller than 2 cm in three different centers were included in the study. The patients were divided into two groups; LPL used (Group1, n:121 patients) and HPL used (Group2, n:96)...
February 10, 2024: Urolithiasis
https://read.qxmd.com/read/38339883/inhibition-of-pde-4-isoenzyme-attenuates-frequency-and-overall-contractility-of-agonist-evoked-ureteral-phasic-contractions
#29
JOURNAL ARTICLE
Iris Lim, Taishi Masutani, Hikaru Hashitani, Russ Chess-Williams, Donna Sellers
The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre-contracted with 5-HT (100 μM). Upon generation of stable phasic contractions, PDE-4 and PDE-5 inhibitors were added cumulatively to separate tissues. PDE-4 inhibitors, such as rolipram (10 nM and greater) and roflumilast (100 nM and greater), resulted in significant attenuation of ureteral contractile responses, while a higher concentration of piclamilast (1 μM and greater) was required to induce a significant depressant effect...
February 2024: Pharmacology Research & Perspectives
https://read.qxmd.com/read/38317880/-desmodium-styracifolium-botanical-and-ethnopharmacological-insights-phytochemical-investigations-and-prospects-in-pharmacology-and-pharmacotherapy
#30
REVIEW
Valentyna Opryshko, Anna Prokhach, Oleh Akimov, Mykola Riabushko, Heorhii Kostenko, Viktoriia Kostenko, Artur Mishchenko, Natalia Solovyova, Vitalii Kostenko
The purpose of this inquiry is to provide a conprehensive summary and analysis of the literature concerning the pharmacological properties of components that can be extracted from Desmodium styracifolium , a preparation in Chinese medicine. This study also aims to explore their potential application in elaborating medicinal products for the effective prevention and treatment of such conditions as urolithiasis, cholelithiasis, type 2 diabetes mellitus, metabolic syndrome, pro-oxidant and inflammatory processes, etc...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38312818/multi-aspect-analysis-of-ureteral-access-sheath-usage-in-retrograde-intrarenal-surgery-a-rirsearch-group-study
#31
JOURNAL ARTICLE
Oktay Özman, Hacı M Akgül, Cem Başataç, Önder Çınar, Eyüp B Sancak, Cenk M Yazıcı, Bülent Önal, Haluk Akpınar
OBJECTIVE: To evaluate the effect of ureteral access sheath (UAS) use and calibration change on stone-free rate and complications of retrograde intrarenal surgery (RIRS). METHODS: Data from 568 patients undergoing RIRS for kidney or upper ureteral stones were retrospectively included. Firstly, patients were compared after 1:1 propensity score matching, according to UAS usage during RIRS (UAS used [+ ] 87 and UAS non-used [- ] 87 patients). Then all UAS+  patients ( n =481) were subdivided according to UAS calibration: 9...
January 2024: Asian Journal of Urology
https://read.qxmd.com/read/38308025/low-dose-versus-conventional-ct-urography-using-dual-source-ct-with-different-time-current-product-values-and-the-same-tube-voltage-image-quality-and-diagnostic-performance-in-various-diagnoses
#32
JOURNAL ARTICLE
Moon Hyung Choi, Sheen-Woo Lee, Seongyong Pak
OBJECTIVES: To compare the image quality and diagnostic performance of low-dose CT urography to that of concurrently acquired conventional CT using dual-source CT. METHODS: This retrospective study included 357 consecutive CT urograms performed by third-generation dual-source CT in a single institution between April 2020 and August 2021. Two-phase CT images (unenhanced phase, excretory phase with split bolus) were obtained with two different tube current-time products (280 mAs for the conventional-dose protocol and 70 mAs for the low-dose protocol) and the same tube voltage (90 kVp) for the two X-ray tubes...
February 2, 2024: British Journal of Radiology
https://read.qxmd.com/read/38301759/a-unified-framework-for-assessing-interaction-effects-among-environmental-exposures-in-epidemiologic-studies-a-case-study-on-temperature-air-pollution-and-kidney-related-conditions-in-new-york-state
#33
JOURNAL ARTICLE
Lingzhi Chu, Kai Chen, Zhuoran Yang, Susan Crowley, Robert Dubrow
BACKGROUND: There are various methods to assess interaction effects. However, current methods have limitations, and quantification of interaction effects is rarely performed. This study aimed to develop a unified quantitative framework for assessing interaction effects. METHODS: We proposed a novel framework using log-linear models with a product term(s) across the exposures that generates parametric bi-variate association and interaction effect surfaces and allows flexible functional forms for exposures in the interaction term(s)...
January 30, 2024: Environmental Research
https://read.qxmd.com/read/38300331/is-traditional-stone-clinic-the-optimal-use-of-nhs-resources
#34
JOURNAL ARTICLE
Joel Corkill, Adrian Sale, Christopher Gallegos, Edward Jefferies
There is no clear guidance on the efficacy of stone follow-up. NICE have been unable to make recommendations with current published evidence. The aim of this study was to understand the patient journey resulting in surgical intervention, and whether traditional stone follow-up is effective. A retrospective review of patients undergoing ureteroscopy (URS) or percutaneous nephrolithotomy (PCNL) over a 3 year period identified 471 patients who underwent these procedures to treat stone disease. Records were interrogated for the following: symptoms, mechanism of booking, reason for intervention, stone size, stone location, risk factors and previous follow-up...
February 1, 2024: Urolithiasis
https://read.qxmd.com/read/38272103/inhibitory-effect-of-incarvillea-diffusa-royle-extract-in-the-formation-of-calcium-oxalate-nephrolithiasis-by-regulating-ros-induced-nrf2-ho-1-pathway-in-rats
#35
JOURNAL ARTICLE
Ming Gao, Tengteng Meng, Faju Chen, Mei Peng, Qiji Li, Liangqun Li, Lishou Yang, Yanfang Yan, Tingfei Deng, Xiong Pan, Zhongsheng Luo, Juan Yang, Xiaosheng Yang
ETHNOPHARMACOLOGICAL RELEVANCE: Calcium oxalate (CaOx) kidney stones are widely acknowledged as the most prevalent type of urinary stones, with high incidence and recurrence rates. Incarvillea diffusa Royle (ID) is a traditionally used medicinal herb in the Miao Minzu of Guizhou province, China, for treating urolithiasis. However, the active components and the underlying mechanism of its pharmacodynamic effects remain unclear. AIM OF THE STUDY: This study aimed to investigate the potential inhibitory effect of the active component of ID on the formation of CaOx nephrolithiasis and elucidate the underlying mechanism...
January 23, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38264681/physicochemical-understanding-of-biomineralization-by-molecular-vibrational-spectroscopy-from-mechanism-to-nature
#36
REVIEW
Hao Liu, Hui Jiang, Xiaohui Liu, Xuemei Wang
The process and mechanism of biomineralization and relevant physicochemical properties of mineral crystals are remarkably sophisticated multidisciplinary fields that include biology, chemistry, physics, and materials science. The components of the organic matter, structural construction of minerals, and related mechanical interaction, etc., could help to reveal the unique nature of the special mineralization process. Herein, the paper provides an overview of the biomineralization process from the perspective of molecular vibrational spectroscopy, including the physicochemical properties of biomineralized tissues, from physiological to applied mineralization...
December 2023: Exploration (Beijing)
https://read.qxmd.com/read/38256393/urolithiasis-in-kidney-transplant-patients-a-multicenter-kser-research-series
#37
MULTICENTER STUDY
Kang Hee Shim, Kwi Bok Choi, Woong Bin Kim, Seung Woo Yang, Do Kyung Kim, Min Soo Choo, Doo Yong Chung, Hae Do Jung, Sin Woo Lee, Bum Soo Kim, Seung Hyun Jeon, Seok Ho Kang, Sunghyun Paick, Joo Yong Lee
Background and Objectives : Urolithiasis occurrence is uncommon in kidney transplantation patients, though it has serious implications, including acute kidney injury in the transplanted kidney. This study investigates the leading causes of urolithiasis in kidney transplantation patients, the diagnostic process, and the outcomes of multimodal management. Materials and Methods : Data collection spanned from January 1997 to December 2021, involving kidney transplantation patients with urolithiasis from the database of the Korean Society of Endourology and Robotics (KSER) research committee...
January 10, 2024: Medicina
https://read.qxmd.com/read/38244281/modified-tube-cystostomy-technique-for-management-of-obstructive-urolithiasis-in-small-ruminants-procedure-and-outcome-in-17-sheep-and-goats
#38
JOURNAL ARTICLE
Rachel E Oman, Luis Rivero, Leslie F Weaver, Katharine M Simpson
OBJECTIVE: To describe the surgical technique and clinical outcome of small ruminants treated for obstructive urolithiasis using a modified tube cystostomy (MTC) technique. ANIMALS: 15 goats and 2 sheep treated with an MTC between March 2018 and February 2023. CLINICAL PRESENTATION: Animals were diagnosed with obstructive urolithiasis on the basis of history, physical examination, and ultrasonographic examination. An MTC was performed with sedation and a local block...
February 1, 2024: Journal of the American Veterinary Medical Association
https://read.qxmd.com/read/38236079/diet-induced-nephrocalcinosis-in-aquarium-raised-juvenile-spotted-wolffish-anarhichas-minor
#39
JOURNAL ARTICLE
Karine Béland, Catherine Rousseau, Stéphane Lair
Wolffish are regularly housed in aquaria, but little data on their husbandry and health is available for caretakers. High occurrence rates of nephrocalcinosis and urolithiasis have been observed in Atlantic Anarhichas lupus and spotted A. minor wolffish housed at 2 Canadian zoological institutions. To explore the effect of diet on nephrocalcinosis and urolithiasis development, a 16 mo prospective study was conducted. A total of 32 juvenile spotted wolffish were randomly assigned to one of 4 experimental groups fed exclusively with the following diet: (1) Skretting® Europa 18 pellets; (2) Mazuri® LS Aquatic Carni-Blend Diet Formula; (3) vitamin-supplemented fish-based diet, and (4) vitamin-supplemented invertebrate-based diet...
January 18, 2024: Diseases of Aquatic Organisms
https://read.qxmd.com/read/38225797/utilizing-the-drug-repurposing-strategy-on-current-drugs-new-leads-for-peptic-ulcers-via-biochemical-and-biomolecular-dynamics-studies
#40
JOURNAL ARTICLE
Majid Khan, Arsalan Nizamani, Luqman Shah, Imran Ullah, Muhammad Waqas, Sobia Ahsan Halim, Farid Shokry Ataya, Ahmed M Elgazzar, Gaber El-Saber Batiha, Ajmal Khan, Ahmed Al-Harrasi
The hyperactivity of urease enzymes plays a crucial role in the development of hepatic coma, hepatic encephalopathy, urolithiasis, gastric and peptic ulcers. Additionally, these enzymes adversely impact the soil's nitrogen efficiency for crop production. In the current study 100 known drugs were tested against Jack Bean urease and Proteus mirabilis urease and identified three inhibitors i.e. terbutaline (compound 1 ), Ketoprofen (compound 2 ) and norepinephrine bitartrate (compound 3 ). As a result, these compounds showed excellent inhibition against Jack Bean urease i...
January 15, 2024: Journal of Biomolecular Structure & Dynamics
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