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https://www.readbyqxmd.com/read/29124877/sporadic-primary-hyperparathyroidism-and-stone-disease-a-comprehensive-metabolic-evaluation-before-and-after-parathyroidectomy
#1
Giovanni S Marchini, Kauy V M Faria, Fábio C M Torricelli, Manoj Monga, Miguel Srougi, William C Nahas, Eduardo Mazzucchi
OBJECTIVES: to characterize the stone risk and the impact of parathyroidectomy on the metabolic profile of patients with primary hyperparathyroidism (PHPT) and urolithiasis. SUBJECTS AND METHODS: We analyzed the prospectively collected charts of patients treated at our stone clinic from Jan/2001-Jan/2016 searching for patients with PHPT and urolithiasis. Imaging evaluation of the kidneys, bones and parathyroid glands were assessed. We analyzed the demographic data, serum and urinary parameters before and after parathyroidectomy...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29082325/endoscopic-treatment-of-intrauterine-device-migration-into-the-bladder-with-stone-formation
#2
Masayuki Sano, Kaoru Nemoto, Takafumi Miura, Yasutomo Suzuki
Background: An intrauterine device is commonly used for contraception globally. Although intrauterine device placement is an effective and safe method of contraception, migration into the bladder with stone formation is a rare and serious complication. The management approaches for an intrauterine device embedded in the bladder include endoscopic procedures and open surgical removal. In this study, we report the case of a patient with recurrent urinary tract infection associated with intrauterine device migration and urolithiasis, who successfully underwent endoscopic treatment combined with laser fragmentation...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29071757/potential-cow-milk-xanthine-oxidase-inhibitory-and-antioxidant-activity-of-selected-phenolic-acid-derivatives
#3
Shivraj Hariram Nile, Young Soo Keum, Arti Shivraj Nile, Young Deuk Kwon, Doo Hwan Kim
Xanthine oxidase (XO) found in all mammals and excess activity leads to urolithiasis. The cow milk XO was purified to 305-fold with a specific activity of 8.76 EU/mg and overall yield of 87% by using DEAE-Sepharose chromatography. The phenolics showed potent XO inhibitory effect with Ki , P1 (0.412), P2 (0.632), P3 (0.585), P4 (0.886), P5 (1.633), P6 (0.503), P7 (2.882), P8 (3.761), P9 (4.487), and P10 (5.841) μM. The phenolics P9 and P10 exhibited uncompetitive inhibition; the phenolics P1, P2, P3, P4, and P6 showed competitive inhibition, and other phenolic acids showed noncompetitive inhibition...
October 26, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29062183/erythrocyte-membrane-bound-atpase-and-antioxidant-enzyme-changes-associated-with-vascular-calcification-is-reduced-by-sodium-thiosulfate
#4
Ramya Ramani, Abirami Ramachandran, Sriram Ravindran, Gino A Kurian
Sodium thiosulfate (STS), a cyanide antidote has been reported to possess antioxidant and calcium chelation effects, useful for the treatment of renal failure due to vascular calcification and urolithiasis. The present study investigated the in vivo modulatory effects of STS on erythrocyte calcium, phosphorous levels, lipid peroxidation, antioxidant enzyme and membrane ATPase activities (Ca(2+), Na(+)K(+), Mg(2+) and 5'' nucleotidase) in an adenine induced model of vascular calcification in rats. Adenine (0...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29037089/patient-reported-outcomes-in-nephrolithiasis-can-we-do-better
#5
Jonathan S Ellison, Marc Williams, Francis X Keeley
PURPOSE: Nephrolithiasis contributes significantly to the worldwide healthcare burden. Patient-reported outcome measures (PROMs) are widely recognized as important outcome measures for patient-centered care. We sought to summarize what is currently known about PROMs in urinary stone disease and to characterize use of PROMs in randomized controlled trials (RCTs) for nephrolithiasis. MATERIALS AND METHODS: Health-related quality of life (HRQOL) in patients with nephrolithiasis is reviewed...
November 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29034196/protective-effect-of-ethyl-acetate-fraction-of-biophytum-sensitivum-extract-against-sodium-oxalate-induced-urolithiasis-in-rats
#6
Anil T Pawar, Niraj S Vyawahare
The methanolic whole plant extract of Biophytum sensitivum (gǎnyìng cǎo) has been found to possess antiurolithiatic effect. The present study was undertaken to evaluate the antiurolithiatic effect of some fractions of methanolic whole plant extract of B. sensitivum (MBS) in rats as a step toward activity-directed isolation of antiurolithiatic component. The MBS was successively extracted with dichloromethane, ethyl acetate, ethanol and water to obtain fractions. Sodium oxalate (70 mg/kg, i.p.) was administered to rats for seven days to develop calcium oxalate urolithiasis...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29025177/-the-recommendations-of-the-s2k-guideline-for-the-diagnosis-therapy-and-metaphylaxis-of-urolithiasis-provide-a-safe-course-of-action-for-ureterorenoscopic-stone-treatment-results-of-the-buster-study
#7
Steffen Lebentrau, Matthias May, Heiko Ziegler, Peter Werthemann, Thomas Enzmann, Martin Schostak, Markus Porsch
Background Given the high incidence, prevalence and rate of recurrence, urolithiasis stone treatment at a high stone-free rate should have a low complication rate. The German S2k guideline (GS2k-GL) for the diagnostic testing, therapy and metaphylaxis of urolithiasis provides recommendations for the first and second choice for stone treatment, depending on stone location and size. Ureterorenoscopy (URS) is the treatment of first choice for most stones. URS is only the second option for renal stones > 20 mm and proximal ureteric stones ≤ 10 mm...
October 12, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28993159/prevention-of-cholesterol-gallstone-disease-by-schaftoside-in-lithogenic-diet-induced-c57bl-6-mouse-model
#8
Meijing Liu, Changhui Liu, Hao Chen, Xiaotao Huang, Xiaohui Zeng, Juncheng Zhou, Suiqing Mi
Schaftoside (SS) is a bioactive compound present in the Herba Desmodii Styracifolii (DS), a herb that has been used to treat cholelithiasis and urolithiasis in Chinese medicine. Whether SS inhibits cholesterol (Ch) gallstone formation has not been investigated. This study examined the effects of oral intake of SS on Ch gallstone formation in C57BL/6 mice fed a lithogenic diet. The rate of gallstone formation was recorded. Levels of Ch, triglycerides (TG) and bile salts (BS) were measured in the bile and serum...
October 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28980141/asymptomatic-hyperuricemia-is-it-time-to-intervene
#9
Binoy J Paul, K Anoopkumar, Vinod Krishnan
Whether to treat hyperuricemia uncomplicated by articular gout, urolithiasis, or uric acid nephropathy is an exercise in clinical judgment and universal agreement is lacking. Patients with coronary artery disease, chronic kidney disease, and early onset hypertension with persistent hyperuricemia are likely to be benefited with urate-lowering therapy. The paradigm of the causative association of hyperuricemia with cardiovascular and chronic kidney diseases seems to have progressed from skepticism to increasing evidence of a true relationship...
December 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28965151/sodium-thiosulfate-preconditioning-ameliorates-ischemia-reperfusion-injury-in-rat-hearts-via-reduction-of-oxidative-stress-and-apoptosis
#10
Sriram Ravindran, Sri Rahavi Boovarahan, Karthi Shanmugam, Ramalingam C Vedarathinam, Gino A Kurian
PURPOSE: Sodium thiosulfate (STS) has of late been proven efficacious in models of urolithiasis and vascular calcification. However, its cardiovascular effects on ischemia reperfusion injury (IR) have not been revealed. Being an antioxidant and calcium chelator, it is assumed to play a vital role in IR as ROS production and calcium overload are major perpetrators of IR injury. METHODS: The cardioprotective effect of STS was evaluated in vitro using H9C2 cardiomyocytes and in vivo using both isolated rat heart and intact left anterior descending artery (LAD) occlusion models of ischemia reperfusion injury...
September 30, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28933510/-unusual-case-of-struvite-urolithiasis-in-a-dog-a-case-report-ein-fallbericht
#11
Julia K Mack, Ellen Kienzle
A dog was referred for nutrition consultation after surgical removal of struvite uroliths from the bladder. Inspection of the dog's current ration revealed a pronounced vitamin-A deficiency together with a marked deficiency of protein, phosphorus and magnesium. Therefore, a supersaturation of the urine with ammonium, magnesium and phosphate, the three constituents of struvite, as a cause of struvite calculi formation appears rather unlikely. Vitamin-A deficiency can promote urinary infections and consequently struvite stone formation because of the lack of the protective effect of vitamin A on the epithelia of the urinary tract...
September 20, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28921009/radiation-overexposure-from-repeated-ct-scans-in-young-adults-with-acute-abdominal-pain
#12
Massimo Tonolini, Elena Valconi, Angelo Vanzulli, Roberto Bianco
PURPOSE: The purpose of this study is to assess the dose of ionizing radiation caused by repeated CT scans performed to investigate non-traumatic acute abdominal conditions in young adults. METHODS: Over 26 months, we collected a cohort of patients aged 18 to 45 years who were subject to at least one urgent contrast-enhanced abdomen/pelvis CT. Patients affected with urolithiasis, HIV infection, tumors, and vascular and chronic inflammatory bowel diseases were excluded...
September 18, 2017: Emergency Radiology
https://www.readbyqxmd.com/read/28900827/lifetime-radiation-exposure-in-patients-with-recurrent-nephrolithiasis
#13
REVIEW
Mohamed A Elkoushy, Sero Andonian
Patients presenting with nephrolithiasis often undergo repeated imaging studies before, during, and after management. Considering the significant risk of stone recurrence in primary stone-formers, repeated imaging studies are not uncommon. Cumulative effects of ionizing radiation exposure from various imaging studies could potentially increase the risk for developing cataracts and solid malignancies in urolithiasis patients. Therefore, practitioners planning or performing imaging studies with ionizing radiation are compelled to keep radiation exposure to humans and the environment as low as possible, thus strictly adhering to the ALARA (As Low as Reasonably Achievable) principles...
September 12, 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28865885/stone-growth-patterns-and-risk-for-surgery-among-children-presenting-with-hypercalciuria-hypocitraturia-and-cystinuria-as-underlying-metabolic-causes-of-urolithiasis
#14
F Zu'bi, M Sidler, E Harvey, R I Lopes, A Hojjat, N Naoum, M Pokarowski, A J Lorenzo, W A Farhat, F Papanikolaou, J Dos Santos
INTRODUCTION: Hypercalciuria, hypocitraturia and cystinuria are the most common underlying metabolic stone abnormalities in children. The present study compared stone growth patterns, stone burden, and the risk of stone-related surgery among these underlying metabolic conditions. METHODS: A retrospective cohort of 356 children with renal stones, followed from 2000 to 2015, was studied. Differences among metabolic groups were determined using Kruskal-Wallis test; the Scheffé-test was used for multiple comparisons to determine differences among single groups...
August 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28861294/retrograde-intrarenal-surgery-for-renal-stones-part-2
#15
REVIEW
Özcan Kılıç, Murat Akand, Ben Van Cleynenbreugel
Retrograde intrarenal surgery (RIRS) has become an effective and safe treatment modality in the management of urinary system stone disease. Recent developments and innovations in the flexible ureterorenoscope and auxiliary equipment have made this procedure easier and more effective with increased success rates. RIRS can be used as a primary treatment in patients with renal stones smaller than 2 cm, prior unsuccessful shock wave lithotripsy, infundibular stenosis, renoureteral malformation, skeletal-muscular deformity, bleeding diathesis and obese patients...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28845947/-dual-energy-computed-tomography-in-diagnosis-of-urolithiasis-a-new-method-for-determining-the-chemical-composition-of-urinary-stones
#16
REVIEW
A G Martov, D A Mazurenko, M M Klimkova, V E Sinitsyn, L A Nersisyan, N K Gadzhiev
The "gold standard" for the diagnosis and evaluation of urinary stones is native computed tomography, which allows determining stone localization and size of with high accuracy. However, this imaging technique has limited diagnostic usefulness in determining the stone chemical composition. The newly introduced method of dual-energy computed tomography, based on obtaining images at two different energy levels is highly effective in determining the composition of urinary stones. The review outlines the principles and methods of performing dual-energy computed tomography using various scanners...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28845946/-nephrolithiasis-coexisting-with-type-2-diabetes-current-concept-of-the-features-of-stone-formation-and-the-effects-of-hypoglycemic-therapy-on-lithogenesis
#17
REVIEW
S K Yarovoi, S A Golovanov, M R Khaziakhmetova, O V Dzhalilov
The article analyzes Russian and international literature examining specific features of the pathogenesis of renal stones in the setting of carbohydrate metabolism disorders. The authors outline the renal effects of the main pharmacological groups of oral hypoglycemic drugs regarding metaphylaxis of nephrolithiasis. An increased risk of nephrolithiasis in type 2 diabetes mellitus is realized through hyperuricemia with concurrent urine acidification. Current literature is lacking studies on the effects of oral hypoglycemic drugs on urine properties...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28845939/-experience-in-ureteroscopy-for-managing-urolithiasis-in-one-clinic-when-does-quantity-transform-into-quality
#18
V Yu Ivanov, V A Malkhasyan, I V Semenyakin, D Yu Pushkar
INTRODUCTION: In recent years, there has been an increasing role of ureteroscopy in managing urinary tract calculi of various locations. Several studies have reported the relationship between the efficacy and safety of ureteroscopic interventions and surgeons skills and hospital caseload volume. The aim of our study was to assess the effectiveness of urethroscopic stone removal, the changes in treatment effectiveness, frequency and types of complications along with gaining experience in these interventions...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28845934/-troyakov-experience-in-using-hytolysin-in-the-integrated-management-of-urinary-tract-infections-and-methapylactics-of-nephrolithiasis
#19
V S Saenko, F P Kapsargin, S V Pesegov, V M
RELEVANCE: Urinary tract infection (UTI) are a risk factor for diseases leading to impairment of renal function and kidney stone disease (KSD). Growing resistance of uropathogens to antibacterial agents is a challenging issue in most countries of the world. Urolithiasis is the second most prevalent urologic condition following urinary tract infections and has a pronounced tendency to recur. Rational stone metaphylaxis leads to a significant reduction in the incidence of recurrent stones...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28808392/antiurolithiatic-effect-of-sirupeelai-samoola-kudineer-a-polyherbal-siddha-decoction-on-ethylene-glycol-induced-renal-calculus-in-experimental-rats
#20
A Hannah Rachel Vasanthi, V Muthulakshmi, V Gayathri, R Manikandan, S Ananthi, Sarah Kuruvilla
BACKGROUND: Sirupeelai Samoola Kudineer (SK), a polyherbal decoction containing four medicinal plants has been used in Siddha system of medicine, practiced in Southern parts of India for the management of urolithiasis. OBJECTIVE: The present study is carried out to scientifically validate the traditional claim and to study the mechanism of action of the drug. MATERIALS AND METHODS: In the present study, anti-urolithiatic effect of SK was evaluated in Sprague-Dawley rats using ethylene glycol through drinking water and intraperitoneal injection of sodium oxalate...
July 2017: Pharmacognosy Magazine
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