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https://www.readbyqxmd.com/read/29246629/one-year-safety-and-efficacy-of-inosine-to-increase-the-serum-urate-level-for-patients-with-parkinson-s-disease-in-japan
#1
Hirotaka Iwaki, Rina Ando, Noriyuki Miyaue, Satoshi Tada, Tomoaki Tsujii, Hayato Yabe, Noriko Nishikawa, Masahiro Nagai, Masahiro Nomoto
BACKGROUND: Epidemiological studies have repeatedly reported that increased serum urate level is associated with a slower progress of Parkinson's disease (PD). The urate precursor, inosine, raises the serum urate level and is therefore a candidate for a disease modifying treatment. However, an elevated serum urate level is a risk factor for gout, urolithiasis, and cardiovascular diseases. Although there have been previous clinical studies, the use of inosine in a clinical setting is still limited, and its safety is unclear, especially in an Asian population...
December 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29239803/ultrasound-guided-ureteroscopy-in-children-safety-and-success
#2
Jeffrey C Morrison, Jason P Van Batavia, Kassa Darge, Christopher J Long, Aseem R Shukla, Arun K Srinivasan
INTRODUCTION: Ureteroscopy has been shown to be a highly efficacious and safe modality for the treatment of pediatric urolithiasis. However, conventional ureteroscopy relies on fluoroscopy for intraoperative guidance, exposing both patient and operating room personnel to ionizing radiation. Pediatric urolithiasis patients are at a particularly increased risk from this radiation exposure. The use of ultrasound in place of fluoroscopy for intraoperative guidance has emerged as one modification that can reduce radiation exposure during ureteroscopy...
October 14, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29236151/the-effects-of-hap-and-macrophage-cells-to-the-expression-of-inflammatory-factors-and-apoptosis-in-hk-2-cells-of-vitro-co-cultured-system
#3
Junchuan Yu, Yaoliang Deng, Zhiwei Tao, Weixia Liang, Xiaofeng Guan, Jihua Wu, Xin Ning, Yunlong Liu, Quan Liu, Ziqi He
This study developed an in vitro system by co-culturing HK-2 cells with different concentration of hydroxyapatite (HAP) and/or macrophage cells to simulate the internal environment of urolithiasis as far as possible, investigating the regulatory effects of macrophage cells on HAP-induced expression of relative inflammatory factors of HK-2 cells. The control group (H group) was only comprised of HK-2 cells. Experimental groups included co-culturing HK-2 cells and macrophage cells (H + M group), co-culturing HK-2 cells and HAP (H + A group), co-culturing macrophage cells and HAP (M + A group), and co-culturing HK-2 cells and macrophage cells with HAP (H + M + A group)...
December 13, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29234532/bilateral-same-session-ureterorenoscopy-a-feasible-approach-to-treat-pan-urinary-stone-disease
#4
Bora Özveren, Murat Tugrul Eren, Hakan Özveri, Uğur Altuğ, Ahmet Şahin
Objectives: To assess treatment effectiveness and safety of bilateral same-session ureterorenoscopy (BSSU) for the management of stone disease involving the entire urinary system. Patients and methods: We reviewed the records of 64 patients who underwent BSSU for the treatment of bilateral ureteric and/or kidney stones. Size, number, location per side, and the total burden of stones were recorded. Data on stenting, lithotripsy, and stone retrieval, and details of hospital stay and operation times were investigated...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29234529/the-effectiveness-of-ureteric-metal-stents-in-malignant-ureteric-obstructions-a-systematic-review
#5
REVIEW
Panagiotis Kallidonis, Dimitrios Kotsiris, Francesco Sanguedolce, Panteleimon Ntasiotis, Evangelos Liatsikos, Athanasios Papatsoris
Objective: To review the literature on the effectiveness, safety and long-term patency of ureteric metal mesh stents (MSs), as a variety of MSs have been used for managing malignant ureteric obstruction over the last three decades. Materials and methods: A systematic review using the search string; Ureter∗ AND (stent OR endoprosthesis) AND metal∗ was conducted on PubMed, Scopus, Web of science and Cochrane Library online databases in May 2016. Prospective, retrospective, and comparative studies including MSs were included...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29212367/assessment-of-patient-and-surgical-variables-including-residency-training-level-on-adverse-events-after-ureteroscopy-for-ureteral-stones-a-multivariate-analysis
#6
Carrie Johans, Woodson Smelser, Chelsea DeRoche, Jack Campbell, James Cummings
Purpose With advances in technology, ureteroscopy is increasingly utilized for the management of urolithiasis. Previous studies have attempted to characterize the post-operative complication and readmission rates relative to the technical difficulty of the procedure. There is limited data exploring resident level of training and its effect on adverse outcomes in these cases. We review our experience with ureteroscopy to create a model to predict factors, including resident experience,that affect rates of post-operative complications Materials and Methods We reviewed ureteroscopies performed at our academic facility from January 2009 to December 2013...
December 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29204974/effects-of-discontinuation-of-urate-lowering-therapy-a-systematic-review
#7
Virginie Beslon, Perrine Moreau, Annabel Maruani, Hubert Maisonneuve, Bruno Giraudeau, Jean-Pascal Fournier
BACKGROUND: Urate-lowering therapy (ULT) is associated with low rates of adherence, leading to a potential risk of relapse of gouty arthritis, tophi, or urolithiasis. Our main aim was to identify the recurrence of gouty arthritis, tophi, or urolithiasis after discontinuation of ULT. Secondary aims included an assessment of ULT reintroduction rates and factors associated with relapse. METHODS: We conducted a systematic literature review of clinical studies investigating the effect of discontinuing any ULT (allopurinol, febuxostat, probenecid, sulfinpyrazone, benzbromarone) in adults on long-term therapy...
December 4, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29197934/effects-of-statin-treatment-with-atorvastatin-on-urolithiasis-associated-urinary-metabolic-risk-factors-an-experimental-study
#8
Mustafa Zafer Temiz, Emrah Yuruk, Kasim Ertas, Oguzhan Zengi, Atilla Semercioz
PURPOSE: To investigate whether atorvastatin has favorable effects on urinary metabolic risk factors associated with urolithiasis. METHODS: Sixteen male Sprague-Dawley rats were randomly divided into two groups, and baseline spot and 24-h urine samples were collected. Distilled water and atorvastatin were administered to rats during 4 weeks in the control and atorvastatin groups, respectively. At the end of the experimental procedure, spot and 24-h urine samples were collected again...
December 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29194397/comparative-evaluation-of-chemical-profiles-of-pyrrosiae-folium-originating-from-three-pyrrosia-species-by-hplc-dad-combined-with-multivariate-statistical-analysis
#9
Wei Xiao, Yude Peng, Zhexu Tan, Qiuyue Lv, Chi-On Chan, Jingyu Yang, Sibao Chen
Pyrrosiae Folium (PF) is a commonly used Chinese herb medicine originating from three Pyrrosia species for the treatment of urinary infection and urolithiasis. According to Chinese medicine practice, different specie origins led to some variations in the therapeutic effects of PF. To ensure the safety and efficacy of PF in clinical practice, it is necessary to establish a reliable and integrative method to distinguish PF occurring from the three species. In the present paper, a HPLC-DAD method was developed and applied to simultaneously analyze five major compounds in PF...
December 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29189886/antiurolithiatic-effect-of-the-taraxasterol-on-ethylene-glycol-induced-kidney-calculi-in-male-rats
#10
Mahboubeh Yousefi Ghale-Salimi, Maryam Eidi, Nasser Ghaemi, Ramezan Ali Khavari-Nejad
Taraxasterol is one of the important constituents of Taraxacum officinale L. (Compositae) with antioxidant potential. The present study was designed to evaluate and compare the antiurolithiatic effects of taraxasterol and potassium citrate in the ethylene glycol induced urolithiatic rat. Urolithiasis was induced by ammonium chloride and ethylene glycol in adult male rats. Taraxasterol (2, 4 and 8 mg/kg) and potassium citrate (2.5 g/kg) were treated for 33 days by gavage. Then, the animals were anesthetized and weighted and blood, urine, liver and kidney sampling were done...
November 30, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29189885/invited-review-the-tale-of-ecirs-endoscopic-combined-intrarenal-surgery-in-the-galdakao-modified-supine-valdivia-position
#11
REVIEW
Cesare Marco Scoffone, Cecilia Maria Cracco
Modern-day percutaneous nephrolithotomy (PNL) has undergone considerable evolution, mainly driven by the improvement in access techniques, endoscopic instrumentation technology, lithotripsy devices and drainage management. The introduction of the supine and supine-modified positions is also part of this evolution, enabling comfortable and safe procedures from an anaesthesiological point of view, and an easy combined retrograde surgery [Endoscopic Combined IntraRenal Surgery (ECIRS)], allowing tailoring of the procedure on the patient, the dynamic anatomy of the collecting system and the urolithiasis...
November 30, 2017: Urolithiasis
https://www.readbyqxmd.com/read/29181438/parsley-mechanism-as-antiurolithiasis-remedy
#12
Fayed Al-Yousofy, Hussein Gumaih, Hassan Ibrahim, Afrah Alasbahy
Parsley is a medicinal plant used widely in urolithiasis. The present study aimed to evaluate the antiurolithiatic effect of parsley and its mechanism. 24 rats divided into four groups: group A (negative control), group B (positive control), group C (cystone® group) and group D (parsley group). Group B were treated with EG and Ammonium chloride (AC). Group C were treated as B plus cystone® and group D was treated as B plus parsley. The period of experiment was 15 days. Urine samples were analysis on days 0 and 15 days...
2017: American Journal of Clinical and Experimental Urology
https://www.readbyqxmd.com/read/29177872/morphological-evaluation-of-the-influence-of-the-peptide-complex-from-tissue-of-porcine-kidneys-on-the-experimental-urolithiasis
#13
A Yu Zharikov, V I Kiselev, I P Saldan, G V Zharikova, A V Lepilov, I P Bobrov
We performed morphological analysis of the effect of the peptide complex from porcine kidneys on the course of experimental urolithiasis modeled in rats by treatment with 1% ethylene glycol solution (in drinking water) for 6 weeks. The peptide complex obtained by acetic acid extraction was administered in a dose of 15 mg. Administration of the peptide complex to animals with experimental kidney stone disease leads to 100% destruction of large and medium stones to the "dust" granularity.
November 27, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29174580/a-systematic-review-and-meta-analysis-comparing-the-efficacy-of-nonsteroidal-anti-inflammatory-drugs-opioids-and-paracetamol-in-the-treatment-of-acute-renal-colic
#14
REVIEW
Sameer A Pathan, Biswadev Mitra, Peter A Cameron
CONTEXT: Renal colic is a common, acute presentation of urolithiasis that requires immediate pain relief. European Association of Urology guidelines recommend nonsteroidal anti-inflammatory drugs (NSAIDs) as the preferred analgesia. However, the fear of NSAID adverse effects and the uncertainty about superior analgesic effect have maintained the practice of advocating intravenous opioids as the initial analgesia. OBJECTIVE: The objective of this systematic review and meta-analysis was to compare the safety and efficacy of NSAIDs with opioids and paracetamol (acetaminophen) for the management of acute renal colic...
November 21, 2017: European Urology
https://www.readbyqxmd.com/read/29169771/antiurolithiatic-activity-of-natural-constituents-isolated-from-aerva-lanata
#15
Basavaraj M Dinnimath, Sunil S Jalalpure, Umesh K Patil
BACKGROUND: Pashanabheda is used as antiurolithiatic in Ayurveda. In the present study, Aerva lanata (L) Juss. ex. Schult (Amaranthaceae) from Western Ghats of India was selected for isolation of active constituents and screening for antiurolithiatic potentials. OBJECTIVE: Screening of compounds isolated from A. lanata for antiurolithiatic potentials. MATERIALS AND METHODS: Ethylene glycol (0.75% v/v) induced urolithiasis model was used to study the antiurolithiatic activity in male Wistar albino rats...
October 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29124877/sporadic-primary-hyperparathyroidism-and-stone-disease-a-comprehensive-metabolic-evaluation-before-and-after-parathyroidectomy
#16
Giovanni S Marchini, Kauy V M Faria, Fábio C M Torricelli, Manoj Monga, Miguel Srougi, William C Nahas, Eduardo Mazzucchi
OBJECTIVES: to characterize the stone risk and the impact of parathyroidectomy on the metabolic profile of patients with primary hyperparathyroidism (PHPT) and urolithiasis. SUBJECTS AND METHODS: We analyzed the prospectively collected charts of patients treated at our stone clinic from Jan/2001-Jan/2016 searching for patients with PHPT and urolithiasis. Imaging evaluation of the kidneys, bones and parathyroid glands were assessed. We analyzed the demographic data, serum and urinary parameters before and after parathyroidectomy...
November 10, 2017: BJU International
https://www.readbyqxmd.com/read/29082325/endoscopic-treatment-of-intrauterine-device-migration-into-the-bladder-with-stone-formation
#17
Masayuki Sano, Kaoru Nemoto, Takafumi Miura, Yasutomo Suzuki
Background: An intrauterine device is commonly used for contraception globally. Although intrauterine device placement is an effective and safe method of contraception, migration into the bladder with stone formation is a rare and serious complication. The management approaches for an intrauterine device embedded in the bladder include endoscopic procedures and open surgical removal. In this study, we report the case of a patient with recurrent urinary tract infection associated with intrauterine device migration and urolithiasis, who successfully underwent endoscopic treatment combined with laser fragmentation...
2017: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/29071757/potential-cow-milk-xanthine-oxidase-inhibitory-and-antioxidant-activity-of-selected-phenolic-acid-derivatives
#18
Shivraj Hariram Nile, Young Soo Keum, Arti Shivraj Nile, Young Deuk Kwon, Doo Hwan Kim
Xanthine oxidase (XO) found in all mammals and excess activity leads to urolithiasis. The cow milk XO was purified to 305-fold with a specific activity of 8.76 EU/mg and overall yield of 87% by using DEAE-Sepharose chromatography. The phenolics showed potent XO inhibitory effect with Ki , P1 (0.412), P2 (0.632), P3 (0.585), P4 (0.886), P5 (1.633), P6 (0.503), P7 (2.882), P8 (3.761), P9 (4.487), and P10 (5.841) μM. The phenolics P9 and P10 exhibited uncompetitive inhibition; the phenolics P1, P2, P3, P4, and P6 showed competitive inhibition, and other phenolic acids showed noncompetitive inhibition...
October 26, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29062183/erythrocyte-membrane-bound-atpase-and-antioxidant-enzyme-changes-associated-with-vascular-calcification-is-reduced-by-sodium-thiosulfate
#19
Ramya Ramani, Abirami Ramachandran, Sriram Ravindran, Gino A Kurian
Sodium thiosulfate (STS), a cyanide antidote has been reported to possess antioxidant and calcium chelation effects, useful for the treatment of renal failure due to vascular calcification and urolithiasis. The present study investigated the in vivo modulatory effects of STS on erythrocyte calcium, phosphorous levels, lipid peroxidation, antioxidant enzyme and membrane ATPase activities (Ca2+, Na+K+, Mg2+ and 5'' nucleotidase) in an adenine induced model of vascular calcification in rats. Adenine (0.75%) was supplemented through the diet for 28 days, which resulted in significantly (P < 0...
October 2017: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29037089/patient-reported-outcomes-in-nephrolithiasis-can-we-do-better
#20
Jonathan S Ellison, Marc Williams, Francis X Keeley
PURPOSE: Nephrolithiasis contributes significantly to the worldwide healthcare burden. Patient-reported outcome measures (PROMs) are widely recognized as important outcome measures for patient-centered care. We sought to summarize what is currently known about PROMs in urinary stone disease and to characterize use of PROMs in randomized controlled trials (RCTs) for nephrolithiasis. MATERIALS AND METHODS: Health-related quality of life (HRQOL) in patients with nephrolithiasis is reviewed...
November 10, 2017: Journal of Endourology
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