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Matthew C Ferroni, Kevin J Rycyna, Timothy D Averch, Michelle J Semins
PURPOSE: Vitamin D deficiency is often detected during metabolic evaluation in the nephrolithiasis population. Multiple vitamin D repletion protocols exist, however their differing impact on urinary stone formation risk factors is unclear. MATERIALS AND METHODS: Patients with a history of calcium stones and vitamin D deficiency (<30ng/ml) were randomized to receive either 1,000 International Units (IU) daily or 50,000 IU weekly of vitamin D supplementation for 6 weeks...
October 17, 2016: Journal of Urology
Chi-Fai Ng, Sylvia Luke, Chi-Hang Yee, Winnie Chu, Ka-Tak Wong, John Yuen
Objectives To perform a prospective study to evaluate the renal protective effects of ramping protocol and pause protocol for extracorporeal shockwave lithotripsy in human subjects. Patients and Methods 320 patients with solitary renal stone <15mm, were randomized to receive one of four protocols: (1) 80% power from beginning until the end of treatment; (2) the first 100 SWs at 40% power, and then 80% power until the end of treatment; (3) the first 100 shocks at 40% power, followed by a 3-minute pause and then further SWs at 80% power until the end of treatment; and (4) the first 100 shocks at 80% power, followed by a 3-minute pause and then further SWs at 80% power until the end of treatment...
October 20, 2016: Journal of Endourology
Ravindra D Hiremath, Sunil S Jalalpure
OBJECTIVE: Aim of this study is to evaluate antiurolithiatic potential of whole plant hydro-alcoholic (30:70) extract of Vernonia cinerea Less. in accordance to its claims made in ancient literature and also being one of the ingredients of cystone, a marketed formulation widely used in the management of urolithiasis. MATERIALS AND METHODS: To induce urolithiasis, 0.75% v/v ethylene glycol was administered orally for 14 days. The curative dose of 400 mg/kg b.w. and preventive doses of 100, 200, and 400 mg/kg b...
July 2016: Indian Journal of Pharmacology
Ryan S Hsi, Thomas Sanford, David S Goldfarb, Marshall L Stoller
PURPOSE: Kidney stone prevention relies on the 24-hour urine collection to diagnose metabolic abnormalities and direct dietary and pharmacologic therapy. While its use is guideline-supported for high risk and interested patients, evidence that the test can accurately predict recurrence or treatment response is limited. We sought to critically reassess the role of the 24-hour urine collection in stone prevention. MATERIALS AND METHODS: In addition to a MEDLINE® search to identify controlled studies of dietary and pharmacologic interventions, evidence supporting the AUA and EAU guidelines for metabolic stone prevention were evaluated...
October 13, 2016: Journal of Urology
Donna Arvans, Yong-Chul Jung, Dionysios Antonopoulos, Jason Koval, Ignacio Granja, Mohamed Bashir, Eltayeb Karrar, Jayanta Roy-Chowdhury, Mark Musch, John Asplin, Eugene Chang, Hatim Hassan
Hyperoxaluria is a major risk factor for kidney stones and has no specific therapy, although Oxalobacter formigenes colonization is associated with reduced stone risk. O. formigenes interacts with colonic epithelium and induces colonic oxalate secretion, thereby reducing urinary oxalate excretion, via an unknown secretagogue. The difficulties in sustaining O. formigenes colonization underscore the need to identify the derived factors inducing colonic oxalate secretion. We therefore evaluated the effects of O...
October 13, 2016: Journal of the American Society of Nephrology: JASN
Mordechai Duvdevani
Endoscopic treatment is currently the mainstay of management for urolithiasis. The high effectiveness of PCNL is well documented in the literature, as are its complications. Bleeding during PCNL is directly related to the size of the dilatation.(1) Several minimally invasive refinements in percutaneous surgery have been made to reduce access related complications and bleeding rates.(2) This was achieved mainly by reducing tract diameter, but the advantage over standard PCNL has yet to be proven.(3) The effectiveness of RIRS is decreasing with increasing stone burden...
October 12, 2016: Journal of Endourology
David T Tzou, Manint Usawachintachit, Kazumi Taguchi, Thomas Chi
Ultrasound has become a mainstay tool in urologists' armamentarium for the diagnosis and management of nephrolithiasis. From starting as a rudimentary form of imaging, it has come to play a more prominent role over time, paralleling evolution in ultrasound technology. Throughout the medical community there is a growing emphasis on reducing the amount of ionizing radiation delivered to patients during routine imaging. As such there has been a resurgence of interest in ultrasound given its lack of associated radiation exposure and proven effectiveness as a diagnostic and therapeutic imaging modality...
October 12, 2016: Journal of Endourology
Sacha L Moore, Ewa Bres-Niewada, Paul Cook, Hannah Wells, Bhaskar K Somani
INTRODUCTION: Kidney stone disease is increasing worldwide with its most common location being in the lower pole. A clear strategy for effective management of these stones is essential in the light of ever increasing choice, effectiveness, and complications of different treatment options. MATERIAL AND METHODS: This review identifies the latest and clinically relevant publications focused on optimal management of lower pole stones. RESULTS: We present an up-to-date European Association of Urology and American Urological Association algorithm for lower pole stones, risks and benefits of different treatments, and changing landscape with the miniaturization of percutaneous stone treatments...
2016: Central European Journal of Urology
Tarik Emre Sener, Goksel Sener, Ozge Cevik, Pinar Eker, Sule Cetinel, Olivier Traxer, Yiloren Tanidir, Cem Akbal
OBJECTIVE: To evaluate the protective effects of melatonin (Mel) on an ethylene glycol-induced nephrolithiasis model in rats. METHODS: Thirty-two Wistar albino rats were divided into 4 groups; control, ethylene glycol (EG), melatonin prevention (Mel+EG+Mel), melatonin treatment (EG+Mel) groups. 0.75% EG was added to drinking water to create nephrolithiasis model. EG group received EG and Mel+EG+Mel group received both EG and melatonin for 8 weeks. In EG+Mel group, EG is given for 8 weeks and melatonin is given for the last 4 weeks of the experiment...
October 4, 2016: Urology
Deepika Aggarwal, Diksha Gautam, Minu Sharma, S K Singla
Bergenin, isolated from Bergenia ligulata is a potent antioxidant and antilithiatic agent. Present work was designed to establish the biochemical role of bergenin on mitochondrial dysfunction in the ethylene glycol induced hyperoxaluric rat model. Bergenin was administrated at a dose of 10mg/kg body wt i.p. from 14th day of establishing the 28 days hyperoxaluria rat model. α-Tocopherol was given as positive control at a dose of 100mg/kg body wt i.p. Mitochondrial dysfunction was studied by evaluating the activities of respiratory chain complexes, mitochondrial membrane potential and reactive oxygen species...
October 5, 2016: European Journal of Pharmacology
Akbar Nouralizadeh, Abbas Basiri, Seyed Amir Mohsen Ziaee, Ali Tabibi, Farzaneh Sharifiaghdas, Behzad Narouie, Reza Sarhangnejad, Reza Valipour, Mehdi Sotoudeh, Hamidreza Shemshaki, Nooshin Ketabi, Saeed Movahed
BACKGROUND: Using percutaneous nephrolitotomy (PCNL) with large adult instruments in treatment of pediatricurolithiasis is still in debate. This study was conducted to evaluate the efficacy and safety of PCNL with adult's instrument in treatment of patients less than 3 years old. METHODS: Data on patient characteristics and outcomes for 261 consecutive children undergoing PCNL at a Labbafinejad University Hospital were collected prospectively from September 2006 to February 2016...
October 1, 2016: Urologia
Arif Demirbas, Berkan Resorlu, Mehmet Melih Sunay, Tolga Karakan, Mehmet Ali Karagoz, Omer Gokhan Doluoglu
Purpose Comparison of effectiveness and safety of ultramini percutaneous nephrolithotomy (UMPNL) and retrograde intrarenal surgery (RIRS) in treatment of moderate-sized renal stones. Material and methods The patients scheduled for surgery due to renal stones with the greatest diameter of 10-25 mm were prospectively analyzed. Patients were randomized into groups with tossing a coin method. The patients that had UMPNL and RIRS were defined as Group I and Group II, respectively. The groups were compared for demograhic data, stone characteristics, operative and postoperative data, stone-free status, and the complications...
October 5, 2016: Journal of Endourology
Maharan Kabha, Snir Dekalo, Sophie Barnes, Ishay Mintz, Haim Matzkin, Mario Sofer
Background: Obstructive nephropathy is an uncommon side effect of sulfadiazine, which is used for the treatment of toxoplasmosis. We present a case of acute renal colic and urine extravasation of a patient shortly after she was started on this medication. Case Presentation: A 31-year-old female presented with acute renal colic 2 weeks after starting treatment with sulfadiazine and pyrimethamine for ocular toxoplasmosis. Results: A noncontrast computed tomography revealed left hydronephrosis and fluid located around the kidney and in the left gutter...
2016: J Endourol Case Rep
Sarwar Noori Mahmood, Hewa Mahmood Toffeq
Background: Percutaneous nephrostolithotomy is an important approach for removing kidney stones. Puncturing and dilatation are two mandatory steps in percutaneous nephrolithotomy (PCNL). Uncommonly, during dilatation, the dilators can cause direct injury to the main renal vein or to their tributaries. Case Presentation: A 75-year-old female underwent PCNL for partial staghorn stone in the left kidney. During puncturing and dilatation, renal vein tributary was injured, and the nephroscope entered the renal vein and inferior vena cava, which was clearly recognized...
2016: J Endourol Case Rep
Xin-Yuan Sun, Jian-Ming Ouyang, Poonam Bhadja, Qin Gui, Hua Peng, Jie Liu
This study aimed to investigate the protective effects of degraded soybean polysaccharides (DSP) on oxidatively damaged African green monkey kidney epithelial (Vero) cells. Low DSP concentration (10 μg/mL) elicited an evident protective effect on H2O2-induced cell injury (0.3 mmol/L). The cell viabilities of the H2O2-treated group and the DSP-protected group were 57.3% and 93.1%, respectively. The cell viability decreased to 88.3% when the dosage was increased to 100 μg/mL. DSP protected Vero cells from H2O2-mediated oxidative damage by enhancing cellular superoxide dismutase activity and total antioxidant capacity and by decreasing malonaldehyde content and lactate dehydrogenase release...
October 5, 2016: Journal of Agricultural and Food Chemistry
Mahmoud Bahmani, Babak Baharvand-Ahmadi, Pegah Tajeddini, Mahmoud Rafieian-Kopaei, Nasrollah Naghdi
INTRODUCTION: Kidney stones are the third most common urinary tract problems after urinary tract infections and prostate pathology. Kidney stones may cause extreme pain and blockage of urine flow. They are usually treated with medications that may cause a number of side-effects. Medicinal herbs are used in different cultures as a reliable source of natural remedies. OBJECTIVES: This study aimed to determine native medicinal plants used by traditional healers of Shiraz for the treatment of kidney stones...
2016: Journal of Renal Injury Prevention
Ahmed R El-Nahas, Mohamed M Elsaadany, Diaa-Eldin Taha, Ahmed M Elshal, Mohamed Abo El-Ghar, Amani M Ismail, Essam A Elsawy, Hazem H Saleh, Ehab W Wafa, Amira Awadalla, Tamer S Barakat, Khaled Z Sheir
OBJECTIVE: To evaluate the protective effects of selenium with vitamins A, C and E (selenium ACE, i.e. antioxidants), verapamil (calcium channel blocker), and losartan (angiotensin receptor blocker) against extracorporeal shockwave lithotripsy (ESWL)-induced renal injury. PATIENTS AND METHODS: A randomised controlled trial was conducted between August 2012 and February 2015. Inclusion criteria were adult patients with a single renal stone (<2 cm) suitable for ESWL...
September 30, 2016: BJU International
Tarek Soliman, Hammouda Sherif, Ahmed Sebaey Ahmed, Ahmed Mohey, Bashir Almohamdy
INTRODUCTION: To detect safety and feasibility of miniperc and SWL for treatment of average sized (1-2 cm) radiopaque lower pole calculi in a prospective randomized manner. MATERIAL AND METHODS: In the period from January 2014 to June 2015, 150 patients were attached to this study with single lower pole radiopaque stone ranging from 10- 20mm. Patients were divided randomly into two groups using computer generated randomization in an equal manner. First group patients were subjected to miniperc procedure while second group patients underwent SWL...
September 27, 2016: Journal of Endourology
Amisha Mittal, Simran Tandon, Surender Kumar Singla, Chanderdeep Tandon
Kidney stone formation during hyperoxaluric condition is inherently dependent on the interaction between renal epithelial cells and calcium oxalate (CaOx) crystals. Although modern medicine has progressed in terms of removal of these stones, recurrence and persistent side effects restricts their use. Strategies involving plant based agents which could be used as adjunct therapy is an area which needs to be explored. Plant proteins having antilithiatic activity is a hitherto unexplored area and therefore, we conducted a detailed identification and characterization of antilithiatic proteins from Terminalia arjuna (T...
2016: PloS One
Sedat Yahsi, Senol Tonyali, Cavit Ceylan, Kenan Y Yildiz, Levent Ozdal
A 34 year-old woman was admitted to our hospital with left flank pain. A non-contrast enhanced computerized tomography (NCCT) revealed a 1.5x2cm left proximal ureter stone. Patient was scheduled for ureterorenoscopy (URS) and stone removal. She was submitted to retrograde intrarenal surgery (RIRS). At the postoperative 1st day, the patient began to suffer from left flank pain. A NCCT was taken, which revealed a subcapsular hematoma and perirenal fluid. The patient was managed conservatively with intravenous fluid, antibiotic and non-steroidal anti-inflammatory drug therapy and was discharged at the postoperative 6th day...
September 20, 2016: International Braz J Urol: Official Journal of the Brazilian Society of Urology
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