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https://www.readbyqxmd.com/read/27924845/caffeine-prevents-kidney-stone-formation-by-translocation-of-apical-surface-annexin-a1-crystal-binding-protein-into-cytoplasm-in-vitro-evidence
#1
Paleerath Peerapen, Visith Thongboonkerd
Recent large 3 cohorts have shown that caffeinated beverage consumption was associated with lower risk of kidney stone disease. However, its protective mechanisms remained unknown and had not been previously investigated. We thus evaluated protective effects of caffeine (1 μM-10 mM) on calcium oxalate monohydrate (COM) kidney stone formation, using crystallization, crystal growth, cell-crystal adhesion, Western blotting, and immunofluorescence assays. The results showed that caffeine reduced crystal number but, on the other hand, increased crystal size, resulting in unchanged crystal mass, consistent with crystal growth that was not affected by caffeine...
December 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27924508/ultrasonography-guided-percutaneous-nephrolithotomy-with-chinese-one-shot-tract-dilation-technique-based-on-stimulated-diuresis-a-report-of-67-cases
#2
Ying Shi, Hua-Geng Liang, Xiong Yang, Bo Hai, Liang Wang, Yi-Fei Xing, Wen Ju, Fu-Qing Zeng, Xiao-Ping Zhang, Wen-Cheng Li
The safety and effectiveness of a novel Chinese one-shot dilation technique based on stimulated diuresis for percutaneous nephrolithotomy (PCNL) were investigated. After the feasibility of the Chinese one-shot dilation based on stimulated diuresis was verified by an animal study, this technique was applied in the clinical practice. A total of 67 patients in our department underwent the modified PCNL from July 2014 to June 2015. After the renal infundibulum was distended by stimulated diuresis, the kidney was punctured under the ultrasonographic guidance via the fornix of the target calyx...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27921023/effects-of-hydrophilic-extract-of-nasturtium-officinale-on-prevention-of-ethylene-glycol-induced-renal-stone-in-male-wistar-rats
#3
Sadrollah Mehrabi, Eslam Askarpour, Farhad Mehrabi, Ramin Jannesar
BACKGROUND: Nasturtium officinale is a traditional herb that is used for diuresis. OBJECTIVES: The aim of this study is to determine the effects of hydrophilic extract of Nasturtium officinale on ethylene glycol-induced renal stone in male Wistar rats. MATERIALS AND METHODS: In this study 32 male Wistar rats were randomly divided in six groups and studied during 30 days. Two groups of negative and healthy control received 1% ethylene glycol in water respectively...
October 2016: Journal of Nephropathology
https://www.readbyqxmd.com/read/27913854/the-role-of-macromolecules-in-the-formation-of-kidney-stones
#4
REVIEW
Jeffrey D Rimer, Ann M Kolbach-Mandel, Michael D Ward, Jeffrey A Wesson
The formation of crystal aggregates, one of the critical processes in kidney stone pathogenesis, involves interactions between crystals (predominantly calcium oxalate monohydrate, COM) and urinary constituents (e.g., proteins), which serve as an adhesive "glue" between crystals in stones. To develop a better understanding of the protein-crystal interactions that lead to crystal aggregation, we have measured the effect of model proteins on bulk COM crystal properties as well as their adsorption on crystal surfaces using three synthetic polyanions: poly(aspartic acid) (polyD), poly(glutamic acid) (polyE), and poly(acrylic acid) (polyAA)...
December 2, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27909619/the-role-of-ultra-mini-percutaneous-nephrolithotomy-in-the-treatment-of-kidney-stones
#5
Abdulkadir Tepeler, İsmail Başıbüyük, Muhammed Tosun, Abdullah Armağan
OBJECTIVE: In our study we aimed to evaluate outcomes of ultra-mini-percutaneous nephrolithotomy (UMP) performed for the treatment of kidney stones. MATERIAL AND METHODS: Between October 2014 and September 2015, a single surgeon performed UMP on a total of 49 consecutive patients with symptomatic kidney stones at our center. Pregnants, anticogulant users, patients with bleeding diathesis pyonephrosis, and partial/complete staghorn stones were excluded from the study...
December 2016: Turkish Journal of Urology
https://www.readbyqxmd.com/read/27900407/do-inhibitors-of-crystallisation-play-any-role-in-the-prevention-of-kidney-stones-a-critique
#6
REVIEW
William G Robertson
A critical examination of data in the literature and in as yet unpublished laboratory records on the possible role of so-called inhibitors of crystallisation in preventing the formation of calcium-containing kidney stones leads to the following conclusions. So-called inhibitors of spontaneous "self-nucleation" are unlikely to play any role in the initiation of the crystallisation of CaOx or CaP in urine because excessive urinary supersaturation of urine with respect to these salts dominates the onset of "self-nucleation" within the normal time frame of the transit of tubular fluid through the nephron (3-4 min)...
November 29, 2016: Urolithiasis
https://www.readbyqxmd.com/read/27885825/multiphase-fluid-solid-coupled-analysis-of-shock-bubble-stone-interaction-in-shockwave-lithotripsy
#7
K G Wang
A novel multiphase fluid-solid coupled computational framework is applied to investigate the interaction of a kidney stone immersed in liquid with a lithotripsy shock wave (LSW) and a gas bubble near the stone. The main objective is to elucidate the effects of a bubble in the shock path to the elastic and fracture behaviors of the stone. The computational framework couples a finite volume two-phase computational fluid dynamics (CFD) solver with a finite element (FE) computational solid dynamics (CSD) solver...
November 24, 2016: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/27878116/minijfil%C3%A2-a-new-safe-and-effective-stent-for-well-tolerated-repeated-extracorporeal-shockwave-lithotripsy-or-ureteroscopy-for-medium-to-large-kidney-stones
#8
Benoit Vogt, Francois-Noel Desfemmes, Arnaud Desgrippes, Yves Ponsot
BACKGROUND: Percutaneous nephrolithotomy (PCNL) is recommended for treating staghorn stones or stones measuring > 20 mm. Extracorporeal shockwave lithotripsy (ESWL) or flexible ureteroscopy (URS) may be used as a complement. However, PCNL can cause trauma to the kidney parenchyma, and patients may find a noninvasive procedure, such as ESWL, to be more attractive. OBJECTIVES: The aim of this study was to evaluate the clinical efficiency of MiniJFil® stenting associated with ESWL or second-line URS for the treatment of medium-to-large kidney stones...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27868099/endourologic-and-open-ureterolithotomy-and-common-sheath-reimplant-for-large-bladder-and-distal-ureteral-calculi
#9
Madeline Cancian, Joseph Brito, Joseph Renzulli, Gyan Pareek
A twenty-eight-year-old female with a history of suprapubic pain and recurrent urinary tract infections presents for urology referral with a kidney, ureter, and bladder radiograph showing a 4.4 cm bladder calculus and 6.5 cm distal left ureteral stone. She underwent effective cystolitholapaxy of the bladder stone. Endourologic attempt (left ureteroscopy) was unsuccessful because of ureteral stone burden. Findings at ureteroscopy revealed a duplicated system on the left with the lower pole moiety joining just proximal to the ureteral orifice...
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27864113/chenopodium-album-linn-leaves-prevent-ethylene-glycol-induced-urolithiasis-in-rats
#10
Indu Sikarwar, Yadu Nandan Dey, Manish M Wanjari, Ajay Sharma, Sudesh N Gaidhani, Ankush D Jadhav
ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Chenopodium album Linn. are traditionally used for correction of kidney diseases and urinary stones. The present work investigated the effect of methanolic and aqueous extracts of leaves of Chenopodium album on experimentally induced urolithiasis in rats to substantiate its traditional use as antilithiatic agent. MATERIALS AND METHODS: The leaf extract was standardized by HPLC. Urolithiasis was induced in rats by administration 0...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27863458/bench-top-and-initial-clinical-evaluation-of-the-shockpulse-stone-eliminator%C3%A2-in-percutaneous-nephrolithotomy
#11
Andre Alessandro Matteliano, Thomas de Los Reyes, Ryan F Paterson, Dirk Lange, Michael Eric Lipkin, Ben Hall Chew
PURPOSE: Standardized bench testing of the new ShockPulseTM intracorporeal lithotripter was performed against three commercially available lithotripsy systems to determine differences and nuances in performance. MATERIALS & METHODS: The ShockPulse intracorporeal lithotripter was tested against the LUS-2TM, CyberWandTM and EMS LithoClastTM in a standardized bench setting using hard (Ultracal-30) and soft (Plaster of Paris) stone phantoms. An in vitro kidney model was used to record the time needed to fragment stone samples into retrievable sized pieces...
November 18, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27862806/a-prospective-and-randomised-trial-comparing-fluoroscopic-total-ultrasonographic-and-combined-guidance-for-renal-access-in-mini-percutaneous-nephrolithotomy
#12
Wei Zhu, Jiasheng Li, Jian Yuan, Yongda Liu, Shaw P Wan, Guanzhao Liu, Wenzhong Chen, Wenqi Wu, Jintai Luo, Dongliang Zhong, Defeng Qi, Ming Lei, Wen Zhong, Ze Zhang, Zhaohui He, Zhijian Zhao, Suilin Lu, Yuji Wu, Guohua Zeng
OBJECTIVE: To compare the safety and efficacy of fluoroscopic guidance (FG), total ultrasonographic guidance (USG), and combined ultrasonographic and fluoroscopic guidance (CG) for percutaneous renal access in mini-percutaneous nephrolithotomy (mini-PCNL). PATIENTS AND METHODS: The present study was conducted between July 2014 and May 2015 as a prospective randomised trial at the First Affiliated Hospital of Guangzhou Medical University. In all, 450 consecutive patients with renal stones of >2 cm were randomised to undergo FG, USG, or CG mini-PCNL (150 patients for each group)...
November 8, 2016: BJU International
https://www.readbyqxmd.com/read/27856353/urolithiasis-in-renal-transplant-donors-and-recipients-an-update
#13
REVIEW
Ahmed M Harraz, Ahmed I Kamal, Ahmed A Shokeir
Urolithiasis in the context of renal transplant is a quite rare event that requires keeping a higher index of suspicion and vigilance. Donors with incidentally discovered asymptomatic renal stones "donor gifted lithiasis" are potentially considered for donation should they are not recurrent stone formers and in the absence of active biochemical disorders. Stone clearance from the donors can be done before donation using shock wave lithotripsy and/or flexible ureteroscopy. Ex vivo ureteroscopy at time of transplant is equally feasible and safe...
November 14, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27856088/tolvaptan-and-kidney-pain-in-patients-with-autosomal-dominant%C3%A2-polycystic-kidney-disease-secondary-analysis-from%C3%A2-a-randomized-controlled-trial
#14
Niek F Casteleijn, Jaime D Blais, Arlene B Chapman, Frank S Czerwiec, Olivier Devuyst, Eiji Higashihara, Anna M Leliveld, John Ouyang, Ronald D Perrone, Vicente E Torres, Ron T Gansevoort
BACKGROUND: Kidney pain is a common complication in patients with autosomal dominant polycystic kidney disease (ADPKD), and data from the TEMPO 3:4 trial suggested that tolvaptan, a vasopressin V2 receptor antagonist, may have a positive effect on kidney pain in this patient group. Because pain is difficult to measure, the incidence of kidney pain leading to objective medical interventions was used in the present study to assess pain. STUDY DESIGN: Secondary analysis from a randomized controlled trial...
November 14, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27847292/the-role-of-the-microbiome-in-kidney-stone-formation
#15
REVIEW
Mansi Mehta, David S Goldfarb, Lama Nazzal
Nephrolithiasis is a complex disease of worldwide prevalence that is influenced by both genetic and environmental factors. About 75% of kidney stones are predominantly composed of calcium oxalate and urinary oxalate is considered a crucial risk factor. Microorganisms may have a role in the pathogenesis and prevention of kidney stones and the involvement of the intestinal microbiome in this renal disease has been a recent area of interest. Oxalobacter formigenes is a gram negative bacteria that degrades oxalate in the gut decreasing urinary oxalate excretion...
November 12, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27829958/antioxidant-and-renoprotective-effects-of-mushroom-extract-implication-in-prevention-of-nephrolithiasis
#16
Ariel Schulman, Matthew Chaimowitz, Muhammad Choudhury, Majid Eshghi, Sensuke Konno
BACKGROUND: The pathogenesis of nephrolithiasis (kidney stone) remains elusive, while several therapeutic options are available but not effective as we expected. Accumulating data yet suggest that oxidative stress (generation of oxygen free radicals) may play a primary role in its occurrence. Particularly, calcium oxalate (CaOx) is a key element in the most common form (> 75%) of kidney stones, and its crystal form known as CaOx monohydrate (COM) has been shown to exert oxidative stress, facilitating CaOx stone formation...
December 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27819138/super-mini-percutaneous-nephrolithotomy-in-the-treatment-of-pediatric-nephrolithiasis-evaluation-of-the-initial-results
#17
Yongda Liu, Wenqi Wu, Aierken Tuerxun, Yang Liu, Abulizi Simayi, Jinxing Huang, Abudukahaer Batuer, Yizhou Zhou, Jiawei Luo, Wen Zhong, Zhijian Zhao, Wei Zhu, Guohua Zeng
OBJECTIVE: To evaluate the efficacy and safety of super-mini percutaneous nephrolithotomy (SMP) in the treatment of pediatric kidney stones. PATIENTS AND METHODS: We reviewed the records of 111 children with renal stones treated with SMP technique in four different centers between September 2014 and September 2015. The indications for SMP treatment in all these kids were either previously failed shock wave lithotripsy or retrograde intrarenal surgery approaches, according to their parents' preferences...
December 5, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27816709/urolithiasis-in-pregnancy
#18
REVIEW
Renato N Pedro, Krishanu Das, Noor Buchholz
Urolithiasis in pregnancy is a major health concern and can potentially affect the well-being of both mother and foetus. Management of this condition often entails simultaneous multidisciplinary involvement of obstetrician, radiologist and urologist. Additionally, adverse effects with usage of anaesthesia, radiation, medications and surgery on mother and foetus, limit utilisation of the full armamentarium of diagnostic and therapeutic modalities that are commonly used in non-pregnant women. This review was conducted using an electronic literature search of peer reviewed journal articles...
November 2, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27810168/ultra-low-dose-low-dose-and-standard-dose-ct-of-the-kidney-ureters-and-bladder-is-there-a-difference-results-from-a-systematic-review-of-the-literature
#19
REVIEW
S Rob, T Bryant, I Wilson, B K Somani
AIM: To investigate whether reducing the radiation dose of computed tomography (CT) of the kidney, ureters, and bladder (KUB) for acute renal colic impacts upon the specificity, sensitivity, and detection of urolithiasis. MATERIALS AND METHODS: A systematic review of the literature over a 20-year period between 1995 and 2015 was conducted of all prospective studies in the English language reporting on adult patients who underwent CT KUB or non-contrast CT for renal colic or urolithiasis...
October 31, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27800047/expanding-living-kidney-donor-criteria-with-ex-vivo-surgery-for-renal-anomalies
#20
Thomas B McGregor, Christie Rampersad, Premal Patel
INTRODUCTION: Renal transplantation remains the gold standard treatment for end-stage renal disease, with living donor kidneys providing the best outcomes in terms of allograft survival. As the number of patients on the waitlist continues to grow, solutions to expand the donor pool are ongoing. A paradigm shift in the eligibility of donors with renal anomalies has been looked at as a potential source to expand the living donor pool. We sought to determine how many patients presented with anatomic renal anomalies at our transplant centre and describe the ex-vivo surgical techniques used to render these kidneys suitable for transplantation...
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
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