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3d model kidney

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https://www.readbyqxmd.com/read/29779157/3d-ct-of-renal-pathology-initial-experience-with-cinematic-rendering
#1
REVIEW
Steven P Rowe, Alexa R Meyer, Michael A Gorin, Pamela T Johnson, Elliot K Fishman
3D computed tomography (CT) visualizations of volumetric data have become an important aspect of diagnostic imaging. The utility of 3D CT has been well described for the imaging of a number of renal pathologies. Recently, a new 3D visualization technique known as cinematic rendering (CR) has become available and provides photorealistic images derived from standard CT acquisitions by use of a complex global lighting model. Herein, we describe a number of normal variant and pathologic conditions of the kidney visualized with CR...
May 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29774184/a-systematic-review-of-clinical-value-of-three-dimensional-printing-in-renal-disease
#2
Zhonghua Sun, Dongting Liu
The aim of this systematic review is to analyse current literature related to the clinical value of three-dimensional (3D) printed models in renal disease. A literature search of PubMed and Scopus databases was performed to identify studies reporting the clinical application and usefulness of 3D printed models in renal disease. Fifteen studies were found to meet the selection criteria and were included in the analysis. Eight of them provided quantitative assessments with five studies focusing on dimensional accuracy of 3D printed models in replicating renal anatomy and tumour, and on measuring tumour volume between 3D printed models and original source images and surgical specimens, with mean difference less than 10%...
April 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29744824/usefulness-of-personalized-three-dimensional-printed-model-on-the-satisfaction-of-preoperative-education-for-patients-undergoing-robot-assisted-partial-nephrectomy-and-their-families
#3
Jun Teishima, Yukihiro Takayama, Shogo Iwaguro, Tetsutaro Hayashi, Shogo Inoue, Keisuke Hieda, Shunsuke Shinmei, Ryoji Kato, Koji Mita, Akio Matsubara
OBJECTIVE: To clarify the usefulness of a personalized three-dimensional (3D) printed model of the kidney for preoperative education among patients who underwent robot-assisted partial nephrectomy (RAPN). METHODS: Twenty-nine cases of patients who planned to undergo RAPN and 19 of their families participated in this study. A three-dimensional model consisting of the kidney, tumors, ureter, inferior vena cava, and abdominal aorta in each case was generated using a Z Printer 450 based on the findings of preoperative enhanced CT...
May 9, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29744639/drug-transporter-expression-profiling-in-a-three-dimensional-kidney-proximal-tubule-in-vitro-nephrotoxicity-model
#4
Dorina Diekjürgen, David W Grainger
Given currently poor toxicity translational predictions for drug candidates, improved mechanistic understanding underlying nephrotoxicity and drug renal clearance is needed to improve drug development and safety screening. Therefore, better relevant and well-characterized in vitro screening models are required to reliably predict human nephrotoxicity. Because kidney proximal tubules are central to active drug uptake and secretion processes and therefore to nephrotoxicity, this study acquired regio-specific expression data from recently reported primary proximal tubule three-dimensional (3D) hyaluronic acid gel culture and non-gel embedded cultured murine proximal tubule suspensions used in nephrotoxicity assays...
May 9, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29693448/three-dimensional-in-vitro-models-answer-the-right-questions-in-adpkd-cystogenesis
#5
Eryn E Dixon, Owen M Woodward
Novel technologies, new understanding of the basement membrane composition, and better comprehension of the embryonic development of the mammalian kidney have led to explosive growth in the use of three dimensional (3D) in vitro models to study a range of human disease pathologies(6, 35). The development of these effective model systems represents a new tool to study the progressive cystogenesis of autosomal dominant polycystic kidney disease (ADPKD). ADPKD is a prevalent and complex monogenetic disease, characterized by the pathological formation of fluid fill cysts in renal tissue(17, 40)...
April 25, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29673945/three-dimensional-texture-analysis-with-machine-learning-provides-incremental-predictive-information-for-successful-shock-wave-lithotripsy-in-patients-with-kidney-stones
#6
Manoj Mannil, Jochen von Spiczak, Thomas Hermanns, Cédric Poyet, Hatem Alkadhi, Christian Daniel Fankhauser
PURPOSE: To determine the predictive value of three-dimensional texture analysis (3D-TA) in computed tomography (CT) images for successful shock wave lithotripsy (SWL) in patients with kidney stones. MATERIAL AND METHODS: Patients with pre and postoperative CT scans, previously untreated kidney stones and a stone diameter of 5-20 mm were included. A total of 224 3D-TA features of each kidney stone, including the attenuation measured in Hounsfield Units (HU), and the clinical variables body mass index (BMI), initial stone size, and skin-to-stone distance (SSD) were analyzed using five commonly used machine learning models...
April 16, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29673177/the-hippo-yap-pathway-regulates-3d-organ-formation-and-homeostasis
#7
Erika Ishihara, Hiroshi Nishina
The vertebrate body shape is formed by the specific sizes and shapes of its resident tissues and organs, whose alignments are essential for proper functioning. To maintain tissue and organ shape, and thereby function, it is necessary to remove senescent, transformed, and/or damaged cells, which impair function and can lead to tumorigenesis. However, the molecular mechanisms underlying three-dimensional (3D) organ formation and homeostasis are not fully clear. Yes-associated protein (YAP) is a transcriptional co-activator that is involved in organ size control and tumorigenesis...
April 17, 2018: Cancers
https://www.readbyqxmd.com/read/29658563/preclinical-evaluation-of-a-novel-engineered-recombinant-human-anti-cd44v6-antibody-for-potential-use-in-radio-immunotherapy
#8
Anja C Mortensen, Diana Spiegelberg, Anna-Karin Haylock, Hans Lundqvist, Marika Nestor
CD44v6 is overexpressed in a variety of cancers, rendering it a promising target for radio-immunotherapy (RIT). In this study, we have characterized a novel engineered recombinant monoclonal anti-CD44v6 antibody, AbN44v6, and assessed its potential for use in RIT using either 177Lu or 131I as therapeutic radionuclides. In vitro affinity and specificity assays characterized the binding of the antibody labeled with 177Lu, 125I or 131I. The therapeutic effects of 177Lu-AbN44v6 and 131I-AbN44v6 were investigated using two in vitro 3D tumor models with different CD44v6 expression...
April 11, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29650317/monte-carlo-based-assessment-of-magic-magicaug-pagatug-and-pagataug-polymer-gel-dosimeters-for-ovaries-and-uterus-organ-dosimetry-in-brachytherapy-nuclear-medicine-and-tele-therapy
#9
Karim Adinehvand, Fereidoun Nowshiravan Rahatabad
BACKGROUND AND OBJECTIVES: Calculation of 3D dose distribution during radiotherapy and nuclear medicine helps us for better treatment of sensitive organs such as ovaries and uterus. In this research, we investigate two groups of normoxic dosimeters based on meta-acrylic acid (MAGIC and MAGICAUG) and polyacrylamide (PAGATUG and PAGATAUG) for brachytherapy, nuclear medicine and Tele-therapy in their sensitive and critical role as organ dosimeters. METHODS: These polymer gel dosimeters are compared with soft tissue while irradiated by different energy photons in therapeutic applications...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29626256/dual-layer-spectral-detector-ct-non-inferiority-assessment-compared-to-dual-source-dual-energy-ct-in-discriminating-uric-acid-from-non-uric-acid-renal-stones-ex-vivo
#10
Lakshmi Ananthakrishnan, Xinhui Duan, Yin Xi, Matthew A Lewis, Margaret S Pearle, Jodi A Antonelli, Harold Goerne, Elysha M Kolitz, Suhny Abbara, Robert E Lenkinski, Julia R Fielding, John R Leyendecker
PURPOSE: To assess the non-inferiority of dual-layer spectral detector CT (SDCT) compared to dual-source dual-energy CT (dsDECT) in discriminating uric acid (UA) from non-UA stones. METHODS: Fifty-seven extracted urinary calculi were placed in a cylindrical phantom in a water bath and scanned on a SDCT scanner (IQon, Philips Healthcare) and second- and third-generation dsDECT scanners (Somatom Flash and Force, Siemens Healthcare) under matched scan parameters. For SDCT data, conventional images and virtual monoenergetic reconstructions were created...
April 7, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29571154/postmortem-interval-estimation-using-the-animal-model-of-postmortem-gas-volume-changes
#11
Chika Iwamoto, Kenoki Ohuchida, Miki Okumura, Yosuke Usumoto, Junji Kishimoto, Masaharu Murata, Noriaki Ikeda, Makoto Hashizume
It is important to estimate the postmortem interval in forensic autopsy. Many methods to estimate the postmortem interval have been reported, and are typically associated with internal examination. However, there are issues such as rejection of autopsy by the family and a lack of forensic doctor in internal examination. Therefore, it is necessary to develop new methods, such as autopsy imaging, that can substitute for internal examination. Here, we first evaluated whether gas volume in the body increased with postmortem interval...
December 20, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29563634/the-tyrosine-kinase-inhibitor-sunitinib-targets-vascular-endothelial-ve-cadherin-a-marker-of-response-to-antitumoural-treatment-in-metastatic-renal-cell-carcinoma
#12
Helena Polena, Julie Creuzet, Maeva Dufies, Adama Sidibé, Abir Khalil-Mgharbel, Aude Salomon, Alban Deroux, Jean-Louis Quesada, Caroline Roelants, Odile Filhol, Claude Cochet, Ellen Blanc, Céline Ferlay-Segura, Delphine Borchiellini, Jean-Marc Ferrero, Bernard Escudier, Sylvie Négrier, Gilles Pages, Isabelle Vilgrain
BACKGROUND: Vascular endothelial (VE)-cadherin is an endothelial cell-specific protein responsible for endothelium integrity. Its adhesive properties are regulated by post-translational processing, such as tyrosine phosphorylation at site Y685 in its cytoplasmic domain, and cleavage of its extracellular domain (sVE). In hormone-refractory metastatic breast cancer, we recently demonstrated that sVE levels correlate to poor survival. In the present study, we determine whether kidney cancer therapies had an effect on VE-cadherin structural modifications and their clinical interest to monitor patient outcome...
March 22, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29546508/intraoperative-utilization-of-advanced-imaging-modalities-in-a-complex-kidney-stone-case-a-pilot-case-study
#13
Andrew R Christiansen, Rami M Shorti, Cory D Smith, William C Prows, Jay T Bishoff
PURPOSE: Despite the increasing use of advanced 3D imaging techniques and 3D printing, these techniques have not yet been comprehensively compared in a surgical setting. The purpose of this study is to explore the effectiveness of five different advanced imaging modalities during a complex renal surgical procedure. METHODS: A patient with a horseshoe kidney and multiple large, symptomatic stones that had failed Extracorporeal Shock Wave Lithotripsy (ESWL) and ureteroscopy treatment was used for this evaluation...
March 15, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29449648/the-role-of-disease-linked-residue-glutamine-913-in-support-of-the-structure-and-function-of-the-human-electrogenic-sodium-bicarbonate-cotransporter-nbce1-a
#14
Evan J Myers, Aniko Marshall, Mark D Parker
Mutations in the sodium bicarbonate cotransporter NBCe1 (SLC4A4) cause proximal renal tubular acidosis (pRTA). We recently described a novel pRTA mutation p.Gln913Arg (Q913R), inherited in compound heterozygous form with p.Arg510His (R510H). Q913R causes intracellular retention of NBCe1 and a 'gain of function' Cl- leak. To learn more about the importance of glutamine at position 913, we substituted a variety of alternative amino-acid residues (Cys, Glu, Lys, Leu, Ser) at position 913. Studying cRNA-injected Xenopus oocytes by voltage clamp, we find that most de novo mutants exhibit close-to-normal NBCe1 activity; only Q913K expresses a Cl- leak...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29441430/prenatal-diagnosis-of-apert-syndrome-using-ultrasound-magnetic-resonance-imaging-and-three-dimensional-virtual-physical-models-three-case-series-and-literature-review
#15
Heron Werner, Pedro Castro, Pedro Daltro, Jorge Lopes, Gerson Ribeiro, Edward Araujo Júnior
OBJECTIVE: This aimed to describe the prenatal diagnosis of three cases of Apert syndrome using two-dimensional (2D) and three-dimensional (3D) ultrasound, magnetic resonance imaging (MRI), and 3D virtual/physical models. METHODS: We retrospectively analyzed three cases of Apert syndrome at our service. The prenatal diagnostic methods used were 2D ultrasound, 3D ultrasound in conventional and HDlive rendering modes, T2-weighted MRI sequences, and 3D virtual/physical models from MRI or 3D ultrasound scan data...
February 13, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29430921/maldi-ms-imaging-reveals-asymmetric-spatial-distribution-of-lipid-metabolites-from-bisphenol-s-induced-nephrotoxicity
#16
Chao Zhao, Peisi Xie, Ting Yong, Hailin Wang, Arthur Chi Kong Chung, Zongwei Cai
With the continuous exposure of environmental pollutants in organisms, determination of abundance variation and spatial distribution of lipids might expand our understanding of toxicological mechanisms occurring in the kidney. Herein, an integrated method involving mass spectrometry (MS)-based lipidomics and matrix-assisted laser desorption/ionization-MS imaging (MALDI-MSI) was developed for the study of nephrotoxicity in mice exposed to 10 and 100 μg bisphenol S (BPS)/kg body weight/day. The BPS exposure remarkable perturbed abundances of 91 potential markers that mainly involved in five metabolic pathways...
March 6, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29421300/development-and-validity-of-a-silicone-renal-tumor-model-for-robotic-partial-nephrectomy-training
#17
Steven M Monda, Jonathan R Weese, Barrett G Anderson, Joel M Vetter, Ramakrishna Venkatesh, Kefu Du, Gerald L Andriole, Robert S Figenshau
OBJECTIVE: To provide a training tool to address the technical challenges of robot-assisted laparoscopic partial nephrectomy, we created silicone renal tumor models using 3-dimensional printed molds of a patient's kidney with a mass. In this study, we assessed the face, content, and construct validity of these models. MATERIALS AND METHODS: Surgeons of different training levels completed 4 simulations on silicone renal tumor models. Participants were surveyed on the usefulness and realism of the model as a training tool...
April 2018: Urology
https://www.readbyqxmd.com/read/29396705/biokinetics-dosimetry-and-radiation-risk-in-infants-after-99m-tc-mag3-scans
#18
J Soares Machado, J Tran-Gia, S Schlögl, A K Buck, M Lassmann
BACKGROUND: Renal scans are among the most frequent exams performed on infants and toddlers. Due to the young age, this patient group can be classified as a high-risk group with a higher probability for developing stochastic radiation effects compared to adults. As there are only limited data on biokinetics and dosimetry in this patient group, the aim of this study was to reassess the dosimetry and the associated radiation risk for infants undergoing 99m Tc-MAG3 renal scans based on a retrospective analysis of existing patient data...
February 2, 2018: EJNMMI Research
https://www.readbyqxmd.com/read/29376589/-application-of-3d-soft-print-models-of-the-kidney-for-treatment-of-patients-with-localized-cancer-of-the-kidney-a-pilot-study
#19
Yu G Alyaev, E S Sirota, E A Bezrukov, D N Fiev, M D Bukatov, A V Letunovskii, I Sh Byadretdinov
AIM: To evaluate the possibility of using 3D-printing in the management of patients with localized kidney cancer. MATERIALS AND METHODS: The study comprised five patients with localized kidney cancer who were treated at the Urology Clinic of the I.M. Sechenov First Moscow State Medical University from January 2016 to April 2017. Along with the standard examination, the patients underwent multispiral computed tomography (MSCT) to produce patient-specific 3D-printed models of the kidney tumors using 3D modeling and 3D printing...
December 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29374811/a-novel-3d-printed-hybrid-simulation-model-for-robotic-assisted-kidney-transplantation-rakt
#20
Raphael Uwechue, Petrut Gogalniceanu, Nicos Kessaris, Nick Byrne, Pankaj Chandak, Jonathon Olsburgh, Kamran Ahmed, Nizam Mamode, Ioannis Loukopoulos
Robotic-assisted kidney transplantation (RAKT) offers key benefits for patients that have been demonstrated in several studies. A barrier to the wider uptake of RAKT is surgical skill acquisition. This is exacerbated by the challenges of modern surgery with reduced surgical training time, patient safety concerns and financial pressures. Simulation is a well-established method of developing surgical skill in a safe and controlled environment away from the patient. We have developed a 3D printed simulation model for the key step of the kidney transplant operation which is the vascular anastomosis...
January 27, 2018: Journal of Robotic Surgery
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