Angela L Caipa Garcia, Jill E Kucab, Halh Al-Serori, Rebekah S S Beck, Madjda Bellamri, Robert J Turesky, John D Groopman, Hayley E Francies, Mathew J Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M Arlt, David H Phillips
Human tissue three-dimensional (3D) organoid cultures have the potential to reproduce in vitro the physiological properties and cellular architecture of the organs from which they are derived. The ability of organoid cultures derived from human stomach, liver, kidney, and colon to metabolically activate three dietary carcinogens, aflatoxin B1 (AFB1 ), aristolochic acid I (AAI), and 2-amino-1-methyl-6-phenylimidazo[4,5- b ]pyridine (PhIP), was investigated. In each case, the response of a target tissue (liver for AFB1 ; kidney for AAI; colon for PhIP) was compared with that of a nontarget tissue (gastric)...
January 17, 2024: Chemical Research in Toxicology