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https://www.readbyqxmd.com/read/28213333/hmba-is-a-putative-hsp70-activator-stimulating-hexim1-expression-that-is-down-regulated-by-estrogen
#1
Rati Lama, Chunfang Gan, Nethrie Idippily, Viharika Bobba, David Danielpour, Monica Montano, Bin Su
Hexamethylene bis-acetamide inducible protein 1 (HEXIM1) is identified as a novel inhibitor of estrogen stimulated breast cell growth, and it suppresses estrogen receptor-α transcriptional activity. HEXIM1 protein level has been found to be downregulated by estrogens. Recently, HEXIM1 has been found to inhibit androgen receptor transcriptional activity as well. Researchers have used Hexamethylene bis-acetamide (HMBA) for decades to stimulate HEXIM1 expression, which also inhibit estrogen stimulated breast cancer cell gene activation and androgen stimulated prostate cancer gene activation...
February 14, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28209447/topical-aqueous-extract-of-ephedra-alata-can-improve-wound-healing-in-an-animal-model
#2
Naim Kittana, Hanood Abu-Rass, Ruba Sabra, Lama Manasra, Hadeel Hanany, Nidal Jaradat, Fatima Hussein, Abdel Naser Zaid
PURPOSE: Ephedra alata (E. alata) is perennial tough shrub plant that grows in Palestine and other regions. It is used often in folk's medicine for the treatment of various diseases. In this project, E. alata extract was tested for its ability to improve wound and burn healing. METHODS: An aqueous extract of E. alata was prepared and underwent several phytochemical analyses for the presence of the major classes of phytochemical compounds. After that, a polyethylene glycol-based ointment containing the extract of E...
January 20, 2017: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28209122/effects-and-meanings-of-a-person-centred-and-health-promoting-intervention-in-home-care-services-a-study-protocol-of-a-non-randomised-controlled-trial
#3
Karin Bölenius, Kristina Lämås, Per-Olof Sandman, David Edvardsson
BACKGROUND: The literature indicates that current home care service are largely task oriented with limited focus on the involvement of the older people themselves, and studies show that lack of involvement might reduce older people's quality of life. Person-centred care has been shown to improve the satisfaction with care and quality of life in older people cared for in hospitals and nursing homes, with limited published evidence about the effects and meanings of person-centred interventions in home care services for older people...
February 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28203412/predictive-models-of-malignant-transudative-pleural-effusions
#4
Lucía Ferreiro, Francisco Gude, María E Toubes, Adriana Lama, Juan Suárez-Antelo, Esther San-José, Francisco Javier González-Barcala, Antonio Golpe, José M Álvarez-Dobaño, Carlos Rábade, Nuria Rodríguez-Núñez, Carla Díaz-Louzao, Luis Valdés
BACKGROUND: There are no firm recommendations when cytology should be performed in pleural transudates, since some malignant pleural effusions (MPEs) behave biochemically as transudates. The objective was to assess when would be justified to perform cytology on pleural transudates. METHODS: Consecutive patients with transudative pleural effusion (PE) were enrolled and divided in two groups: malignant and non-MPE. Logistic regression analysis was used to estimate the probability of malignancy...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28203071/long-acting-bronchodilators-with-or-without-inhaled-corticosteroids-and-30-day-readmission-in-patients-hospitalized-for-copd
#5
Raju Bishwakarma, Wei Zhang, Yong-Fang Kuo, Gulshan Sharma
BACKGROUND: The ability of a long-acting muscarinic antagonist (LAMA) and long-acting beta 2 agonists (LABAs; long-acting bronchodilators, LABDs) with or without inhaled corticosteroids (ICSs) to reduce early readmission in hospitalized patients with COPD is unknown. METHODS: We studied a 5% sample of Medicare beneficiaries enrolled in Medicare parts A, B and D and hospitalized for COPD in 2011. We examined prescriptions filled for LABDs with or without ICSs (LABDs±ICSs) within 90 days prior to and 30 days after hospitalization...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28202504/expression-profiling-of-circulating-microvesicles-reveals-intercellular-transmission-of-oncogenic-pathways
#6
Gloria Milani, Tobia Lana, Silvia Bresolin, Sanja Aveic, Anna Pasto, Chiara Frasson, Geertruy Te Kronnie
: Circulating microvesicles (MVs) have been described as important players in cell-to-cell communication carrying biological information under normal or pathological condition. MVs released by cancer cells may incorporate diverse biomolecules (e.g. active lipids, proteins and RNA) which can be delivered and internalized by recipient cells, potentially altering gene expression of recipient cells and eventually impacting disease progression. Leukemia in vitro model systems were used to investigate MVs as vehicles of protein-coding messages...
February 15, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28196583/opportunistic-screening-for-atrial-fibrillation-versus-detecting-symptomatic-patients-aged-65-years-and-older-a-cluster-controlled-clinical-trial
#7
Virginia González Blanco, Luis Ángel Pérula de Torres, Enrique Martín Rioboó, Miguel Ángel Martínez Adell, Juan Manuel Parras Rejano, Jesús González Lama, Javier Ruiz Moruno, Remedios Martín Alvarez, José Ángel Fernández García, Joaquin Ruiz de Castroviejo, Ana Roldán Villalobos, Roger Ruiz Moral
OBJECTIVE: The goal of this study was to assess the effectiveness of opportunistic screening through pulse palpation in the early detection of atrial fibrillation in subjects aged≥65 years versus detection through an active search for patients with symptoms and/or complications and sequelae associated. MATERIAL AND METHODS: This was a cluster randomized controlled trial performed in 48 primary care centers of the Spanish National Healthcare System. A total of 368 physicians and nurses were randomized...
January 6, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28187652/new-species-and-records-of-i-zavreliella-i-kieffer-1920-from-neotropical-region-diptera-chironomidae
#8
Lívia Maria Fusari, Luiz Carlos Pinho, Carlos José Einicker Lamas
A new species of Zavreliella Kieffer, Zavreliella kambeba sp. n., is described, based on male adults collected in the Amazon rainforest, Brazil. Further seven Zavreliella species are recorded for new localities in Brazil, with the first Neotropical record of Z. marmorata (van der Wulp). The genus Zavreliella is now composed of 15 species, of which adult males are reviewed in a key to their identification.
January 19, 2017: Zootaxa
https://www.readbyqxmd.com/read/28185242/long-acting-muscarinic-antagonist-lama-plus-long-acting-beta-agonist-laba-versus-laba-plus-inhaled-corticosteroid-ics-for-stable-chronic-obstructive-pulmonary-disease-copd
#9
REVIEW
Nobuyuki Horita, Atsushi Goto, Yuji Shibata, Erika Ota, Kentaro Nakashima, Kenjiro Nagai, Takeshi Kaneko
BACKGROUND: Three classes of inhaler medications are used to manage chronic obstructive pulmonary disease (COPD): long-acting beta-agonists (LABA), long-acting muscarinic antagonists (LAMA), and inhaled corticosteroids (ICS). When two classes of medications are required, LAMA plus LABA (LAMA+LABA) and LABA plus ICS (LABA+ICS) are often selected because these combinations can be administered via a single medication device. The previous Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidance recommended LABA+ICS as the first-line treatment for managing stable COPD in high-risk people of categories C and D...
February 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28180242/11-beta-dehydrogenase-type-2-activity-is-not-reduced-in-treatment-resistant-hypertension
#10
Lama Ghazi, Tanja Dudenbostel, Maria El Hachem, Mohammed Siddiqui, Chee Paul Lin, Suzanne Oparil, David A Calhoun
No abstract text is available yet for this article.
February 9, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28178954/experiencing-aging-or-demystifying-myths-impact-of-different-geriatrics-and-gerontology-teaching-strategies-in-first-year-medical-students
#11
Alessandra Lamas Granero Lucchetti, Giancarlo Lucchetti, Isabella Noceli de Oliveira, Alexander Moreira-Almeida, Oscarina da Silva Ezequiel
BACKGROUND: With the aging of the population comes a greater need for geriatric and gerontology teaching. However, there is currently a dearth of investigations on the impact of different educational methodologies for teaching in this area early in medical courses. The present study aims to determine the impact of two educational strategies on the topic "Geriatrics and Gerontology" ("experiencing aging" and "myths of aging") as compared to a control group (no intervention) on the attitudes, empathy and knowledge of first year medical students...
February 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/28177498/effects-of-switching-to-the-menthol-tobacco-heating-system-2-2-smoking-abstinence-or-continued-cigarette-smoking-on-clinically-relevant-risk-markers-a-randomized-controlled-open-label-multicenter-study-in-sequential-confinement-and-ambulatory-settings-part
#12
Frank Lüdicke, Patrick Picavet, Gizelle Baker, Christelle Haziza, Valerie Poux, Nicola Lama, Rolf Weitkunat
No abstract text is available yet for this article.
February 8, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28177489/effects-of-switching-to-the-tobacco-heating-system-2-2-menthol-smoking-abstinence-or-continued-cigarette-smoking-on-biomarkers-of-exposure-a-randomized-controlled-open-label-multicenter-study-in-sequential-confinement-and-ambulatory-settings-part-1
#13
Frank Lüdicke, Patrick Picavet, Gizelle Baker, Christelle Haziza, Valerie Poux, Nicola Lama, Rolf Weitkunat
No abstract text is available yet for this article.
February 8, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28176893/indacaterol-glycopyrronium-versus-salmeterol-fluticasone-in-asian-patients-with-copd-at-a-high-risk-of-exacerbations-results-from-the-flame-study
#14
Jadwiga A Wedzicha, Nanshan Zhong, Masakazu Ichinose, Michael Humphries, Robert Fogel, Chau Thach, Francesco Patalano, Donald Banerji
BACKGROUND: The FLAME study demonstrated that indacaterol/glycopyrronium (IND/GLY), the fixed-dose combination of a long-acting β2-agonist (LABA, IND) and a long-acting muscarinic antagonist (LAMA, GLY), was superior to salmeterol/fluticasone combination (SFC) in preventing exacerbations in COPD patients with a high risk of exacerbations. In this study, we report a prespecified analysis of the efficacy and safety of IND/GLY versus SFC in Asian patients from the FLAME study. PATIENTS AND METHODS: Patients from Asian centers with moderate-to-very severe COPD and ≥1 exacerbation in the previous year from the 52-week, randomized FLAME study were included...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28175050/p280-therapeutic-drug-monitoring-of-infliximab-and-adalimumab-for-detection-of-patients-at-risk-of-loss-of-response-in-inflammatory-bowel-disease
#15
J Gonzalez-Lopez, J M Giráldez-Montero, R Ferreiro, A Lorenzo, M J Lamas, J E Dominguez-Munoz, M Barreiro-de Acosta
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28169875/vitamin-a-and-d-deficiencies-associated-with-incident-tuberculosis-in-hiv-infected-patients-initiating-antiretroviral-therapy-in-multinational-case-cohort-study
#16
Mark W Tenforde, Ashish Yadav, David W Dowdy, Nikhil Gupte, Rupak Shivakoti, Wei-Teng Yang, Noluthando Mwelase, Cecilia Kanyama, Sandy Pillay, Wadzanai Samaneka, Breno Santos, Selvamuthu Poongulali, Srikanth Tripathy, Cynthia Riviere, Sima Berendes, Javier R Lama, Sandra W Cardoso, Patcharaphan Sugandhavesa, Parul Christian, Richard D Semba, Thomas B Campbell, Amita Gupta
INTRODUCTION: Numerous micronutrients have immunomodulatory roles that may influence risk of tuberculosis (TB), but the association between baseline micronutrient deficiencies and incident TB after antiretroviral (ART) initiation in HIV-infected individuals is not well characterized. METHODS: We conducted a case-cohort study (n=332) within a randomized trial comparing three ART regimens in 1571 HIV treatment-naïve adults from nine countries. A subcohort of 30 patients was randomly selected from each country (n=270)...
February 6, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28167457/laparoscopic-diagnosis-and-repair-of-spigelian-hernia-a-case-report-and-literature-review
#17
Raul Mederos, Jose R Lamas, Javier Alvarado, Moises Matos, Ivett Padron, Anika Ramos
INTRODUCTION: Spigelian hernias are a rare type of hernia which protrude through the abdominal wall at the semilunar line. They are especially difficult to diagnose due to their location and non-specific symptoms and are often overlooked because of their positioning between muscular layers. Patients may present with localized pain which can aid the diagnosis. CT and ultrasound are also helpful. PRESENTATION OF CASE: We present the case of a 75-year-old female patient who presented to Hialeah Hospital with a one-year history of abdominal pain localized to the left lower quadrant...
January 20, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28161254/pharmacological-inhibition-of-dna-methyltransferase-1-promotes-neuronal-differentiation-from-rodent-and-human-nasal-olfactory-stem-progenitor-cell-cultures
#18
I Franco, L Ortiz-López, B Roque-Ramírez, G B Ramírez-Rodríguez, M Lamas
Nasal olfactory stem and neural progenitor cells (NOS/PCs) are considered possible tools for regenerative stem cell therapies in neurodegenerative diseases. Neurogenesis is a complex process regulated by extrinsic and intrinsic signals that include DNA-methylation and other chromatin modifications that could be experimentally manipulated in order to increase neuronal differentiation. The aim of the present study was the characterization of primary cultures and consecutive passages (P2-P10) of NOS/PCs isolated from male Swiss-Webster (mNOS/PCs) or healthy humans (hNOS/PCs)...
February 1, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28159259/comparison-of-methods-for-analysis-of-resveratrol-in-dietary-vegetable-supplements
#19
E Moretón-Lamas, M Lago-Crespo, M A Lage-Yusty, J López-Hernández
Resveratrol is a stilbene, which is one of a group of polyphenols in many plant foods. Interest in this substance lies in its potential health benefits. This study aimed to compare two different methods, chromatographic and constant-wavelength synchronous spectrofluorimetry, an alternative technique to determine the amount of resveratrol dietary supplements, as a model for more complex foods. High-performance liquid chromatography-photodyode array detector-mass spectrometry/mass spectrometry was used to confirm the results...
June 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28158976/the-role-of-serum-procalcitonin-in-establishing-the-diagnosis-and-prognosis-of-pleural-infection
#20
Giles Dixon, Adriana Lama-Lopez, Oliver J Bintcliffe, Anna J Morley, Clare E Hooper, Nick A Maskell
BACKGROUND: Bacterial pleural infection requires prompt identification to enable appropriate investigation and treatment. In contrast to commonly used biomarkers such as C-reactive protein (CRP) and white cell count (WCC), which can be raised due to non-infective inflammatory processes, procalcitonin (PCT) has been proposed as a specific biomarker of bacterial infection. The utility of PCT in this role is yet to be validated in a large prospective trial. This study aimed to identify whether serum PCT is superior to CRP and WCC in establishing the diagnosis of bacterial pleural infection...
February 3, 2017: Respiratory Research
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