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https://www.readbyqxmd.com/read/27905655/-gastrointestinal-bezoars
#1
Ricardo Espinoza González
Gastrointestinal bezoars are a concretion of indigested material that can be found in the gastrointestinal tract of humans and some animals. This material forms an intraluminal mass, more commonly located in the stomach. During a large period of history animal bezoars were considered antidotes to poisons and diseases. We report a historical overview since bezoars stones were thought to have medicinal properties. This magic conception was introduced in South America by Spanish conquerors. In Chile, bezoars are commonly found in a camelid named guanaco (Lama guanicoe)...
August 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27903331/biomarkers-in-prodromal-parkinson-disease-a-qualitative-review
#2
Christine A Cooper, Lama M Chahine
BACKGROUND: Over the past several years, the concept of prodromal Parkinson disease (PD) has been increasingly recognized. This term refers to individuals who do not fulfill motor diagnostic criteria for PD, but who have clinical, genetic, or biomarker characteristics suggesting risk of developing PD in the future. Clinical diagnosis of prodromal PD has low specificity, prompting the need for objective biomarkers with higher specificity. In this qualitative review, we discuss objectively defined putative biomarkers for PD and prodromal PD...
November 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27895551/oct4-methylation-mediated-silencing-as-an-epigenetic-barrier-preventing-m%C3%A3-ller-glia-dedifferentiation-in-a-murine-model-of-retinal-injury
#3
Luis I Reyes-Aguirre, Monica Lamas
Müller glia (MG) is the most abundant glial type in the vertebrate retina. Among its many functions, it is capable of responding to injury by dedifferentiating, proliferating, and differentiating into every cell types lost to damage. This regenerative ability is notoriously absent in mammals. We have previously reported that cultured mammalian MG undergoes a partial dedifferentiation, but fails to fully acquire a progenitor phenotype and differentiate into neurons. This might be explained by a mnemonic mechanism comprised by epigenetic traits, such as DNA methylation...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27894858/elbow-dislocation-with-ipsilateral-fracture-of-the-distal-radius-associated-with-a-brachial-artery-injury-a-new-pathological-condition-of-traumatic-origin
#4
L Trigo Lahoz, C Lamas Gomez, J Sarasquete Reiriz, J de Caso Rodriguez, I Proubasta Renart
Elbow dislocation associated with ipsilateral fracture of the distal radius and a brachial artery injury is an uncommon traumatic entity. The two references of this injury combination appeared in 2015, although both authors did not realise that they were the first two cases published in the medical literature. Although mentioned in the text of the articles, no mention was made of the fracture of the distal radius in the titles. The purpose of this paper is to present three cases with this new traumatic pathological entity, explaining its pathogenetic mechanism, the treatment used, and the results obtained...
November 25, 2016: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/27890845/physician-modified-c3-excluder-endograft-as-the-preferred-solution-to-treat-a-juxtarenal-para-anastomotic-aneurysm
#5
Thibault Couture, Raphaël Coscas, Henri Lamas, Amélie Mlynski, Isabelle Javerliat, Olivier Goeau-Brissonniere, Marc Coggia
PURPOSE: Feasibility and early satisfactory results of physician-modified endografts have been reported. Most reports described the use of Cook Dacron aortic endografts (Cook Medical Inc, Bloomingtion, Ind). However, in some specific anatomic features (short aortic lenght, narrow aorta), use of this device may not appropriate. CASE REPORT: We here report a case of juxtarenal aortic aneuvrysm proximal to a former aortobifemoral graft in a high surgical risk patient...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27890625/pharmacological-treatment-optimization-for-stable-chronic-obstructive-pulmonary-disease-proposals-from-the-soci%C3%A3-t%C3%A3-de-pneumologie-de-langue-fran%C3%A3-aise
#6
M Zysman, F Chabot, P Devillier, B Housset, C M Panzini, N Roche
The Société de Pneumologie de Langue Française proposes a decision algorithm on long-term pharmacological COPD treatment. A working group reviewed the literature published between January 2009 and May 2016. This document lays out proposals and not guidelines. It only focuses on pharmacological treatments except vaccinations, smoking cessation treatments and oxygen therapy. Any COPD diagnosis, based on pulmonary function tests, should lead to recommend smoking cessation, vaccinations, physical activity, pulmonary rehabilitation in case of activity limitation, and short-acting bronchodilators...
November 24, 2016: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/27890024/end-of-life-experiences-and-deathbed-phenomena-as-reported-by-brazilian-healthcare-professionals-in-different-healthcare-settings
#7
Claudia Soares Dos Santos, Bianca Sakamoto Ribeiro Paiva, Alessandra Lamas Granero Lucchetti, Carlos Eduardo Paiva, Peter Fenwick, Giancarlo Lucchetti
OBJECTIVE: The objectives of the present study were to describe and compare the characteristics and reports of end-of-life experiences (ELEs) by healthcare professionals at different institutions and to investigate the influence of religious beliefs on these reports. METHOD: A multicenter study was carried out in Brazil that included six nursing homes (NHs), a cancer hospital (ONC), and a palliative care (PC) unit. Sociodemographic data, ELE reports (Fenwick's questionnaire), religiosity (the Duke Religion Index), spirituality (the Spirituality Self-Rating Scale), and mental health (the DASS-21 questionnaire) were assessed...
November 28, 2016: Palliative & Supportive Care
https://www.readbyqxmd.com/read/27883227/preterm-infants-exhibited-less-pain-during-a-heel-stick-when-they-were-played-the-same-music-their-mothers-listened-to-during-pregnancy
#8
Lina Kurdahi Badr, Taline Demerjian, Tania Daaboul, Hanan Abbas, Mirvat Hasan Zeineddine, Lama Charafeddine
AIM: Playing music during painful procedures has shown inconsistent benefits for preterm infants. This study observed preterm infants during a heel stick procedure to assess whether listening to the music their mothers listened to during pregnancy had any impact on their pain, physiological and behavioural parameters. METHODS: We randomly exposed 42 preterm infants, with a mean gestational age of 31.8 ±2.79 weeks, to the music their mothers listened to during pregnancy, recorded lullabies and no music, before, during and after a heel stick...
November 24, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27882479/albendazole-microcrystal-formulations-based-on-chitosan-and-cellulose-derivatives-physicochemical-characterization-and-in-vitro-parasiticidal-activity-in-trichinella-spiralis-adult-worms
#9
Josefina Priotti, Ana V Codina, Darío Leonardi, María D Vasconi, Lucila I Hinrichsen, María C Lamas
The oral route has notable advantages to administering dosage forms. One of the most important questions to solve is the poor solubility of most drugs which produces low bioavailability and delivery problems, a major challenge for the pharmaceutical industry. Albendazole is a benzimidazole carbamate extensively used in oral chemotherapy against intestinal parasites, due to its extended spectrum activity and low cost. Nevertheless, the main disadvantage is the poor bioavailability due to its very low solubility in water...
November 23, 2016: AAPS PharmSciTech
https://www.readbyqxmd.com/read/27876089/rapid-onset-obesity-hypoventilation-hypothalamic-dysfunction-autonomic-dysregulation-and-neuroendocrine-tumor-syndrome-with-a-homogenous-enlargement-of-the-pituitary-gland-a-case-report
#10
Lama Aljabban, Lina Kassab, Nour Alhuda Bakoura, Mohammad Fayez Alsalka, Ismaeil Maksoud
BACKGROUND: Rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation syndrome is a rare pediatric disorder with a variable sequence of clinical presentations, undefined etiology, and high risk of mortality. Our patient presented an unusual course of the disease accompanied by a homogenous mild enlargement of her pituitary gland with an intact pituitary-endocrine axis which, to the best of our knowledge, represents a new finding in rapid-onset obesity with hypoventilation, hypothalamic dysfunction, and autonomic dysregulation syndrome...
November 22, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27871894/optimizing-gdna-extraction-from-fresh-frozen-meningioma-tissue-for-downstream-genetic-analysis
#11
D T Proctor, E H Yoo, Z Vujadinovic, S Lama, G van Marle, G R Sutherland
OBJECTIVE: Meningioma is the most common brain tumor. Genetic mutations in meningioma that include deletion of the neurofibromatosis type 2 gene, (NF2), offer diagnostic information on tumor behavior, recurrence and potential response to treatment. Obtaining high-grade genetic material is critical for accurate, sensitive and robust molecular testing. Currently, no standardized procedure exists for extracting gDNA from meningioma, and this problem was addressed in this report. METHOD: This study compared the yield and quality of extracted gDNA from patient meningioma specimens using an optimized phenol chloroform method and two commercial silica column-based extractions kits and tested respective performances as template in qPCR tests and multiplex ligation-dependent probe amplification (MLPA) NF2 screening...
November 19, 2016: Clinical Biochemistry
https://www.readbyqxmd.com/read/27871851/dual-function-of-ixr1-in-transcriptional-regulation-and-recognition-of-cisplatin-dna-adducts-is-caused-by-differential-binding-through-its-two-hmg-boxes
#12
A Vizoso-Vázquez, M Lamas-Maceiras, R Fernández-Leiro, A Rico-Díaz, M Becerra, M E Cerdán
Ixr1 is a transcriptional factor involved in the response to hypoxia, which is also related to DNA repair. It binds to DNA through its two in-tandem high mobility group box (HMG-box) domains. Each function depends on recognition of different DNA structures, B-form DNA at specific consensus sequences for transcriptional regulation, or distorted DNA, like cisplatin-DNA adducts, for DNA repair. However, the contribution of the HMG-box domains in the Ixr1 protein to the formation of different protein-DNA complexes is poorly understood...
November 18, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27865150/event-level-analysis-of-alcohol-consumption-and-condom-use-in-partnership-contexts-among-men-who-have-sex-with-men-and-transgender-women-in-lima-peru
#13
Jeanne R Delgado, Eddy R Segura, Jordan E Lake, Jorge Sanchez, Javier R Lama, Jesse L Clark
BACKGROUND: We explored the association between alcohol use and condomless receptive (CRAI) and insertive (CIAI) anal intercourse within partnership contexts of men who have sex with men (MSM) and transgender women (TGW) in Lima, Peru. METHODS: From 2012-2014, we surveyed men and TGW (n=1607) who reported anal intercourse with ≥1 male or TGW. Alcohol use with up to 3 sexual partners during the prior 90days was evaluated. Bivariate and multivariate analyses used generalized estimating equations to assess event-level associations between alcohol use, CRAI, CIAI, and partnership characteristics while adjusting for participant clustering from multiple partners...
November 3, 2016: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/27863901/a-systematic-review-of-the-literature-on-disorders-of-sleep-and-wakefulness-in-parkinson-s-disease-from-2005-to-2015
#14
REVIEW
Lama M Chahine, Amy W Amara, Aleksandar Videnovic
Sleep disorders are among the most common non-motor manifestations in Parkinson's disease (PD) and have a significant negative impact on quality of life. While sleep disorders in PD share most characteristics with those that occur in the general population, there are several considerations specific to this patient population regarding diagnosis, management, and implications. The available research on these disorders is expanding rapidly, but many questions remain unanswered. We thus conducted a systematic review of the literature published from 2005 to 2015 on the following disorders of sleep and wakefulness in PD: REM sleep behavior disorder, insomnia, nocturia, restless legs syndrome and periodic limb movements, sleep disordered breathing, excessive daytime sleepiness, and circadian rhythm disorders...
August 31, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27857426/nonlinear-optical-responses-in-two-dimensional-transition-metal-dichalcogenide-multilayer-ws-sub-2-sub-wse-sub-2-sub-mos-sub-2-sub-and-mo-sub-0-5-sub-w-sub-0-5-sub-s-sub-2-sub-publisher-s-note
#15
S Bikorimana, P Lama, A Walser, R Dorsinville, S Anghel, A Mitioglu, A Micu, L Kulyuk
This publisher's note amends the Funding section of a recent publication [Opt. Express24, 20685 (2016].
November 14, 2016: Optics Express
https://www.readbyqxmd.com/read/27853383/uk-specific-cost-effectiveness-of-tiotropium-olodaterol-fixed-dose-combination-versus-other-lama-laba-combinations-in-patients-with-copd
#16
Abigail Tebboth, Andrew Ternouth, Nuria Gonzalez-Rojas
OBJECTIVE: The aim of this study is to assess the cost-effectiveness of other long-acting muscarinic antagonist + long-acting β2 agonist combinations in comparison with Spiolto(®) Respimat(®) (tiotropium + olodaterol fixed-dose combination [FDC]) for maintenance treatment to relieve symptoms in adult patients with chronic obstructive pulmonary disease. METHODS: A previously published individual-level Markov model was adapted for the perspective of the UK health care system, in line with recommendations from the National Institute for Health and Care Excellence...
2016: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/27852080/prevalence-of-small-airway-dysfunction-among-copd-patients-with-different-gold-stages-and-its-role-in-the-impact-of-disease
#17
Ernesto Crisafulli, Roberta Pisi, Marina Aiello, Matteo Vigna, Panagiota Tzani, Anna Torres, Giuseppina Bertorelli, Alfredo Chetta
BACKGROUND: In chronic obstructive pulmonary disease (COPD) patients, small-airway dysfunction (SAD) is considered a functional hallmark of disease. However, the exact role of SAD in the clinical presentation of COPD is not yet completely understood; moreover, it is not known whether SAD may have a relationship with the impact of disease. OBJECTIVES: To evaluate the prevalence of SAD among COPD patients categorized by the old and the new GOLD classification and to ascertain whether there is a relationship between SAD and impact of disease measured by the COPD Assessment Test (CAT) questionnaire...
November 17, 2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27851112/1476-assessing-the-3rd-international-consensus-definition-for-septic-shock-sepsis-3-in-cancer-patients
#18
Lama Nazer, Aseel Abusara, Feras Hawari
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851078/1442-characteristics-and-outcomes-of-critically-ill-cancer-patients-with-septic-shock-an-8-year-study
#19
Lama Nazer, Rawan Daoud, Marciana Bargash, Marciana Bargash, Feras Hawari
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847292/the-role-of-the-microbiome-in-kidney-stone-formation
#20
REVIEW
Mansi Mehta, David S Goldfarb, Lama Nazzal
Nephrolithiasis is a complex disease of worldwide prevalence that is influenced by both genetic and environmental factors. About 75% of kidney stones are predominantly composed of calcium oxalate and urinary oxalate is considered a crucial risk factor. Microorganisms may have a role in the pathogenesis and prevention of kidney stones and the involvement of the intestinal microbiome in this renal disease has been a recent area of interest. Oxalobacter formigenes is a gram negative bacteria that degrades oxalate in the gut decreasing urinary oxalate excretion...
November 12, 2016: International Journal of Surgery
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