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https://www.readbyqxmd.com/read/29332320/the-role-of-tiotropium-olodaterol-dual-bronchodilator-therapy-in-the-management-of-chronic-obstructive-pulmonary-disease
#1
REVIEW
David M G Halpin
Bronchodilator therapy is central to the management of chronic obstructive pulmonary disease and are recommended as the preferred treatment by the Global Obstructive Lung Disease Initiative (GOLD). Long acting anti-muscarinics (LAMA) and long acting β₂ agonists (LABA) are both more effective than regular short-acting drugs but many patients remain symptomatic despite monotherapy with these drugs. Combination therapy with LAMA and LABA increases the therapeutic benefit while minimizing dose-dependent side effects of long-acting bronchodilator therapy...
January 2018: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29330999/reasons-of-self-discharge-from-nursery-of-a-tertiary-care-hospital
#2
Rabia Abbas, Khawaja Ahmad Irfan Waheed, Talal Waqar, Muhammad Anwar, Rafia Gul, Sikandar Hayat, Syeda Tehseen Fatima, Muhammad Azhar
BACKGROUND: Patients who leave against medical advice (LAMA) from a health facility is a recognized problem. In neonatology practice this issue is particularly sensitive as repercussions can be severe. The purpose of this study was to evaluate the factors influencing the decision of parents to self-discharge their babies against medical advice. METHODS: This descriptive case series was conducted in the Department of Neonatology, of the Children's Hospital and the Institute of Child Health, Lahore from January to June 2015...
October 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29329234/poor-people-are-hospitalized-three-times-more-for-mental-health-services-than-the-non-poor-in-central-valley-california
#3
Gyanesh Lama, Emmanuel Alcala, John A Capitman
Introduction: Providing health insurance to the poor has become a standard policy response to health disparities between the poor and the non-poor. It is often assumed that if the poor people are given health insurance, they will use preventative care, which will prevent more expensive emergency visits and inpatient hospitalization, and in turn, it will save healthcare cost in the long run. This paper presents the findings from our study in California about what happens to the poor when they are given health insurance...
January 12, 2018: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/29329003/modified-forest-rotation-lengths-long-term-effects-on-landscape-scale-habitat-availability-for-specialized-species
#4
Jean-Michel Roberge, Karin Öhman, Tomas Lämås, Adam Felton, Thomas Ranius, Tomas Lundmark, Annika Nordin
We evaluated the long-term implications from modifying rotation lengths in production forests for four forest-reliant species with different habitat requirements. By combining simulations of forest development with habitat models, and accounting both for stand and landscape scale influences, we projected habitat availability over 150 years in a large Swedish landscape, using rotation lengths which are longer (+22% and +50%) and shorter (-22%) compared to current practices. In terms of mean habitat availability through time, species requiring older forest were affected positively by extended rotations, and negatively by shortened rotations...
January 9, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29324815/biophysical-insights-from-a-single-chain-camelid-antibody-directed-against-the-disrupted-in-schizophrenia-1-protein
#5
Antony S K Yerabham, Andreas Müller-Schiffmann, Tamar Ziehm, Andreas Stadler, Sabrina Köber, Xela Indurkhya, Rita Marreiros, Svenja V Trossbach, Nicholas J Bradshaw, Ingrid Prikulis, Dieter Willbold, Oliver H Weiergräber, Carsten Korth
Accumulating evidence suggests an important role for the Disrupted-in-Schizophrenia 1 (DISC1) protein in neurodevelopment and chronic mental illness. In particular, the C-terminal 300 amino acids of DISC1 have been found to mediate important protein-protein interactions and to harbor functionally important phosphorylation sites and disease-associated polymorphisms. However, long disordered regions and oligomer-forming subdomains have so far impeded structural analysis. VHH domains derived from camelid heavy chain only antibodies are minimal antigen binding modules with appreciable solubility and stability, which makes them well suited for the stabilizing proteins prior to structural investigation...
2018: PloS One
https://www.readbyqxmd.com/read/29323239/specific-phospholipids-regulate-the-acquisition-of-neuronal-and-astroglial-identities-in-post-mitotic-cells
#6
Aneley Montaner, Themis Taynah da Silva Santana, Timm Schroeder, Marcelo Einiker-Lamas, Javier Girardini, Marcos Romualdo Costa, Claudia Banchio
Hitherto, the known mechanisms underpinning cell-fate specification act on neural progenitors, affecting their commitment to generate neuron or glial cells. Here, we show that particular phospholipids supplemented in the culture media modify the commitment of post-mitotic neural cells in vitro. Phosphatidylcholine (PtdCho)-enriched media enhances neuronal differentiation at the expense of astroglial and unspecified cells. Conversely, phosphatidylethanolamine (PtdEtn) enhances astroglial differentiation and accelerates astrocyte maturation...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322375/predictors-of-short-term-lama-ineffectiveness-in-treatment-na%C3%A3-ve-patients-with-moderate-to-severe-copd
#7
Vladimir Fijačko, Marina Labor, Mirjana Fijačko, Sanda Škrinjarić-Cincar, Slavica Labor, Iva Dumbović Dubravčić, Tatjana Bačun, Aleksandar Včev, Sanja Popović-Grle, Davor Plavec
BACKGROUND: No specific (only subgroup) recommendations for the use of long-acting muscarinic antagonists in chronic obstructive pulmonary disease (COPD) exist. The aim of this exploratory hypothesis generating study was to assess whether different phenotypic/endotypic characteristics could be determinants of the short-term ineffectiveness of the initial tiotropium bromide monotherapy in treatment naïve moderate to severe COPD patients. METHODS: A total of 51 consecutively recruited COPD patients were followed for 3 months after the initial evaluation and prescribed initial treatment (tiotropium)...
January 10, 2018: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/29319158/effect-of-restriction-vegan-diet-s-on-muscle-mass-oxidative-status-and-myocytes-differentiation-a-pilot-study
#8
D Vanacore, G Messina, S Lama, G Bitti, P Ambrosio, G C Tenore, A Messina, V Monda, S Zappavigna, M Boccellino, E Novellino, M Monda, P Stiuso
This study was conceived to evaluate the effects of three different diets on body composition, metabolic parameters and serum oxidative status. We enrolled three groups of healthy men (omnivores, vegetarians and vegans) with similar age, weight and BMI and we observed a significant decrease in muscle mass index and lean body mass in vegan compared to vegetarian and omnivore groups, and higher serum homocysteine levels in vegetarians and vegans compared to omnivores. We studied whether serum from omnivore, vegetarian and vegan subjects affected oxidative stress, growth and differentiation of both cardiomyoblast cell line H9c2 and H-H9c2 (H9c2 treated with H2 O2 to induce oxidative damage)...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29310962/glaucomatous-optic-neuropathy-associated-with-nocturnal-dip-in-blood-pressure-findings-from-the-maracaibo-aging-study
#9
Jesús D Melgarejo, Joseph H Lee, Michele Petitto, Juan B Yépez, Felipe A Murati, Zhezhen Jin, Carlos A Chávez, Rosa V Pirela, Gustavo E Calmón, Winston Lee, Matthew P Johnson, Luis J Mena, Lama A Al-Aswad, Joseph D Terwilliger, Rando Allikmets, Gladys E Maestre, C Gustavo De Moraes
PURPOSE: To determine which nocturnal blood pressure (BP) parameters (low levels or extreme dipper status) are associated with an increased risk of glaucomatous damage in Hispanics. DESIGN: Observational cross-sectional study. PARTICIPANTS: A subset (n = 93) of the participants from the Maracaibo Aging Study (MAS) who met the study eligibility criteria were included. These participants, who were at least 40 years of age, had measurements for optical tomography coherence, visual field (VF) tests, 24-hour BP, office BP, and intraocular pressure <22 mmHg...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29308450/eating-patterns-and-health-outcomes-in-patients-with-type-2-diabetes
#10
Roberta Aguiar Sarmento, Juliana Peçanha Antonio, Ingrid Lamas de Miranda, Bruna Bellicanta Nicoletto, Jussara Carnevale de Almeida
Purpose: To evaluate the relationship between eating patterns and therapeutic target's achieving in patients with type 2 diabetes. Methods: In this cross-sectional study, patients underwent clinical, laboratory, and nutritional evaluations. Dietary intake was assessed by a quantitative food frequency questionnaire and eating patterns identified by cluster analysis. The therapeutic targets were as follows: blood pressure, <140/90 mm Hg; BMI, <25 kg/m2 (<27 kg/m2 for elderly); waist circumference, <94 cm for men and <80 cm for women; fasting plasma glucose, <130 mg/dL; HbA1c, <7%; triglycerides, <150 mg/dL; HDL-cholesterol, >40 mg/dL for men and >50 mg/dL for women; LDL-cholesterol, <100 mg/dL...
January 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29305870/ophthalmic-econazole-hydrogels-for-the-treatment-of-fungal-keratitis
#11
Victoria Díaz-Tomé, Andrea Luaces-Rodríguez, Jesús Silva-Rodríguez, Sara Blanco-Dorado, Laura García-Quintanilla, José Llovo Taboada, José Blanco-Méndez, Michel Herranz, María Gil-Martínez, María Jesús Lamas, Miguel González-Barcia, Francisco J Otero-Espinar, Anxo Fernández-Ferreiro
Econazole is a feasible alternative treatment in the management of fungal keratitis. Nevertheless, its low water solubility is considered the main limitation to the incorporation into ophthalmic formulations. In this work, econazole nitrate is solubilized by using cyclodextrins to achieve an optimum therapeutic concentration. Phase solubility diagrams suggest a-cyclodextrin as the most effective cyclodextrin and later the inclusion complex formed with this one was characterised in solution by 1D, 2D-NMR and molecular modelling...
January 3, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29305841/the-role-of-fixed-dose-dual-bronchodilator-therapy-in-treating-copd
#12
REVIEW
Antonio Anzueto, Marc Miravitlles
The incidence of chronic obstructive pulmonary disease (COPD) is rising in the United States, and the disease represents a significant source of morbidity and mortality. Primary care providers face many challenges in COPD diagnosis and treatment, as different clinical phenotypes require personalized treatment approaches. Patient adherence and inhaler technique also contribute to treatment outcomes. Around 48% of primary care providers are unaware of guidelines and recommendations for COPD diagnosis and treatment, which may lead to misdiagnosis or undertreatment of COPD symptoms...
January 3, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29305733/preclinical-ex-vivo-evaluation-of-the-diagnostic-performance-of-a-new-device-for-in-situ-label-free-fluorescence-spectral-analysis-of-breast-masses
#13
Marie-Christine Mathieu, Alexis Toullec, Charlotte Benoit, Richard Berry, Pierre Validire, Pauline Beaumel, Yves Vincent, Pierre Maroun, Philippe Vielh, Lama Alchab, René Farcy, Hélène Moniz-Koum, Marie-Pierre Fontaine-Aupart, Suzette Delaloge, Corinne Balleyguier
OBJECTIVES: To assess the diagnostic performance of a new device for in situ label-free fluorescence spectral analysis of breast masses in freshly removed surgical specimens, in preparation for its clinical development. METHODS: Sixty-four breast masses from consenting patients who had undergone either a lumpectomy or a mastectomy were included. Label-free fluorescence spectral acquisitions were obtained with a 25G fibre-containing needle inserted into the mass...
January 5, 2018: European Radiology
https://www.readbyqxmd.com/read/29305653/the-effect-of-height-and-shoulder-to-hip-ratio-on-interpersonal-space-in-virtual-environment
#14
Farid Pazhoohi, Carlos Silva, João Lamas, Sandra Mouta, Jorge Santos, Joana Arantes
Previous research has associated men's physical features such as height and Shoulder-to-Hip Ratio (SHR) with dominance. Proxemics literature has suggested that the interpersonal space (comfort distance) increases in threatening and uncomfortable situations and decreases in unthreatening and comfortable situations. In the current study, we aimed to investigate the effect of different heights and SHRs on comfortable interpersonal distance by systematic manipulation of virtual confederates bodily features. More specifically, participants determined their comfort distances from virtual male confederates with different heights and SHRs in a virtual environment...
January 5, 2018: Psychological Research
https://www.readbyqxmd.com/read/29302318/methods-used-in-adaptation-of-health-related-guidelines-a-systematic-survey
#15
Rima A Abdul-Khalek, Andrea J Darzi, Mohammad W Godah, Lama Kilzar, Chantal Lakis, Arnav Agarwal, Elias Abou-Jaoude, Joerg J Meerpohl, Wojtek Wiercioch, Nancy Santesso, Hneine Brax, Holger Schünemann, Elie A Akl
Background: Adaptation refers to the systematic approach for considering the endorsement or modification of recommendations produced in one setting for application in another as an alternative to de novo development. Objective: To describe and assess the methods used for adapting health-related guidelines published in peer-reviewed journals, and to assess the quality of the resulting adapted guidelines. Methods: We searched Medline and Embase up to June 2015...
December 2017: Journal of Global Health
https://www.readbyqxmd.com/read/29297450/knowledge-of-tuberculosis-and-vaccine-trial-preparedness-in-lima-peru
#16
E Shu, M E Sobieszczyk, V G Sal Y Rosas, P Segura, J T Galea, L Lecca, J Sanchez, J R Lama
SETTING: A safe, effective vaccine would improve tuberculosis (TB) control worldwide. Extensive community engagement will be essential to ensure the interest and participation of populations at highest risk. OBJECTIVE/METHOD: To inform the potential implementation of efficacy studies, we assessed TB knowledge, attitudes towards licensed vaccines and willingness to participate in future TB vaccine efficacy trials among 262 household contacts of 79 recently diagnosed pulmonary TB cases in Lima, Peru...
December 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29297386/illness-recognition-decision-making-and-care-seeking-for-maternal-and-newborn-complications-a-qualitative-study-in-sarlahi-district-nepal
#17
Tsering P Lama, Subarna K Khatry, Joanne Katz, Steven C LeClerq, Luke C Mullany
BACKGROUND: Identification of maternal and newborn illness and the decision-making and subsequent care-seeking patterns are poorly understood in Nepal. We aimed to characterize the process and factors influencing recognition of complications, the decision-making process, and care-seeking behavior among families and communities who experienced a maternal complication, death, neonatal illness, or death in a rural setting of Nepal. METHODS: Thirty-two event narratives (six maternal/newborn deaths each and 10 maternal/newborn illnesses each) were collected using in-depth interviews and small group interviews...
December 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29297057/association-of-cardiovascular-risk-with-inhaled-long-acting-bronchodilators-in-patients-with-chronic-obstructive-pulmonary-disease-a-nested-case-control-study
#18
Meng-Ting Wang, Jun-Ting Liou, Chen Wei Lin, Chen-Liang Tsai, Yun-Han Wang, Yu-Juei Hsu, Jyun-Heng Lai
Importance: The associations between cardiovascular disease (CVD) and inhaled long-acting β2-agonists (LABAs) or long-acting antimuscarinic antagonists (LAMAs) in chronic obstructive pulmonary disease (COPD) are greatly debated. Pivotal and relevant randomized clinical trials included prior LABA or LAMA users and excluded patients with baseline CVD; therefore, cardiovascular events arising from first-time LABA or LAMA use, if any, could not be observed. There is an urgent need to examine whether new use of and duration since initiating LABAs and LAMAs could act as important determinants of cardiovascular events...
January 2, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29291504/pre-slaughter-cattle-welfare-indicators-for-use-in-commercial-abattoirs-with-voluntary-monitoring-systems-a-systematic-review
#19
REVIEW
Natyieli Losada-Espinosa, Morris Villarroel, Gustavo A María, Genaro C Miranda-de la Lama
Animal welfare has become an important subject of public, economic and political concern, leading to the need to validate indicators that are feasible to use at abattoirs. A systematic review was carried out, which identified 72 cattle welfare indicators (CWI) that were classified into four categories (physiological, morphometric, behavioral and meat quality). Their validity and feasibility for use in abattoirs were evaluated as potential measures of cattle welfare during transportation to the abattoir and at the abattoir itself...
December 8, 2017: Meat Science
https://www.readbyqxmd.com/read/29291068/phylogeny-of-anophelinae-using-mitochondrial-protein-coding-genes
#20
Peter G Foster, Tatiane Marques Porangaba de Oliveira, Eduardo S Bergo, Jan E Conn, Denise Cristina Sant'Ana, Sandra Sayuri Nagaki, Silvio Nihei, Carlos Einicker Lamas, Christian González, Caio Cesar Moreira, Maria Anice Mureb Sallum
Malaria is a vector-borne disease that is a great burden on the poorest and most marginalized communities of the tropical and subtropical world. Approximately 41 species of Anopheline mosquitoes can effectively spread species of Plasmodium parasites that cause human malaria. Proposing a natural classification for the subfamily Anophelinae has been a continuous effort, addressed using both morphology and DNA sequence data. The monophyly of the genus Anopheles, and phylogenetic placement of the genus Bironella, subgenera Kerteszia, Lophopodomyia and Stethomyia within the subfamily Anophelinae, remain in question...
November 2017: Royal Society Open Science
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