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https://www.readbyqxmd.com/read/29147449/prostatic-lymphoma-masquerading-as-urinary-retention-and-hematuria-with-review-of-literature
#1
Tsering Gyalpo Lama Tamang, Prabhsimranjot Singh, Jonathan Garellek, Sonali Malhotra, Abhinav Binod Chandra, William Solomon
Lymphomas of prostate are very rare tumors. They are not commonly considered in the clinical and histological differential diagnosis of prostatic enlargement. We report a case of a 49-year-old man who presented to emergency department with several weeks of difficulty in urination, for which he was being treated for benign prostate hyperplasia with no improvement. Computerized tomography scan showed lobulated mass originating from the superior aspect of the prostate with right inguinal lymph node involvement and no distant organ metastatic disease...
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29146261/a-comprehensive-review-of-non-enterica-subspecies-of-salmonella-enterica
#2
REVIEW
Alexandre Lamas, José Manuel Miranda, Patricia Regal, Beatriz Vázquez, Carlos Manuel Franco, Alberto Cepeda
Salmonella is a major foodborne pathogen with a complex nomenclature. This genus is composed of two species, S. enterica and S. bongori. S. enterica is divided into six subspecies. S. enterica subspecies enterica is composed of more than 1500 serotypes with some of great importance, such as S. Typhimurium and S. Enteritidis. S. enterica subsp. enterica is responsible of more than 99% of human salmonellosis and therefore it is widely studied. However, the non-enterica subspecies of S. enterica have been little studied...
January 2018: Microbiological Research
https://www.readbyqxmd.com/read/29143092/laparoscopic-appendectomy-minimally-invasive-surgery-training-improves-outcomes-in-basic-laparoscopic-procedures
#3
Katherine D Gray, Joshua G Burshtein, Lama Obeid, Maureen D Moore, Gregory Dakin, Alfons Pomp, Cheguevara Afaneh
BACKGROUND: To determine whether minimally invasive surgery (MIS) training improves outcomes in laparoscopic appendectomy, a procedure that is commonly performed in general surgery training. METHODS: Retrospective review was conducted of all patients undergoing laparoscopic appendectomy for suspected acute appendicitis between 2014 and 2015 at a single-center, tertiary-care academic institution. Patients operated on by MIS-trained surgeons (MIS group) were compared to those operated on by general surgeons (GS group)...
November 15, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29142810/the-role-of-ivabradine-in-diastolic-heart-failure-with-preserved-ejection-fraction-a-doppler-echocardiographic-study
#4
Federico Cacciapuoti, Valerio Massimo Magro, Michele Caturano, Diana Lama, Fulvio Cacciapuoti
Background: Ivabradine (IVA) is effective in patients with coronary artery disease (CAD) or systolic heart failure in sinus rhythm. Its action consists in reducing heart rate (HR) and improving the time of left ventricular (LV) diastolic filling. The aim of this study was to evaluate the effects of IVA added to conventional therapy on patients with diastolic heart failure (DHF) and preserved ejection fraction (HFpEF). Methods: We evaluated 25 patients with DHF in the New York Heart Association (NYHA) Class II-III and sinus rhythm...
October 2017: Journal of Cardiovascular Echography
https://www.readbyqxmd.com/read/29141073/forces-of-tool-tissue-interaction-to-assess-surgical-skill-level
#5
Taku Sugiyama, Sanju Lama, Liu Shi Gan, Yaser Maddahi, Kourosh Zareinia, Garnette R Sutherland
Importance: The application of optimal forces between surgical instruments and tissue is fundamental to surgical performance and learning. To date, this force has not been measured clinically during the performance of microsurgery. Objectives: To establish a normative catalog of force profiles during the performance of surgery, to compare force variables among surgeons with different skill levels, and to evaluate whether such a force-based metric determines or differentiates skill level...
November 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/29140706/a-galactosylated-pro-drug-of-ursodeoxycholic-acid-design-synthesis-characterization-and-pharmacological-effects-in-a-rat-model-of-estrogen-induced-cholestasis
#6
Francesca Di Guida, Claudio Pirozzi, Salvatore Magliocca, Anna Santoro, Adriano Lama, Roberto Russo, Maria Nieddu, Lucia Burrai, Gianpiero Boatto, Maria Pina Mollica, Federica Sodano, Loretta Lazzarato, Konstantin Chegaev, Rosaria Meli, Giuseppina Mattace Raso, Maria Grazia Rimoli
Ursodeoxycholic acid (UDCA) is considered the first-choice therapy for cholestatic disorders. To enhance solubility and exploit specific transporters in liver, we synthesized a new galactosyl pro-drug of UDCA (UDCAgal). Ethinylestradiol (EE)-induced cholestasis was used to study and compare the effects of UDCAgal with UDCA on bile flow, hepatic canalicular efflux transporter expression, and inflammation. UDCAgal resulted quite stable both at pH 7.4 and 1.2 and regenerated the parent drug after incubation in human plasma...
November 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29138547/efficacy-of-tiotropium-and-indacaterol-monotherapy-and-their-combination-on-dynamic-lung-hyperinflation-in-copd-a-random-open-label-crossover-study
#7
Keisaku Fujimoto, Haruna Yamazaki, Midori Ura, Yoshiaki Kitaguchi
Background and objective: The difference in efficacy of long-acting muscarinic antagonists (LAMAs) and long-acting β2-agonists (LABAs) for dynamic lung hyperinflation (DLH) in COPD is unclear. The purpose of this study was to elucidate the difference in efficacy of LAMA and LABA alone and the combination thereof for DLH. Subjects and methods: Thirty stable patients were enrolled and randomly divided into two groups following baseline measurements. One group was treated with 5 μg tiotropium (Respimat inhaler) for 4 weeks following a 4-week treatment with 150 μg indacaterol, while the other group was treated with indacaterol for 4 weeks following a 4-week treatment with tiotropium...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29136302/the-sociotype-in-dermatology
#8
S E Marron, R Del Moral, J Navarro, S Lamas, P C Marijuan, L Tomas-Aragones
Skin diseases can be the cause of a significant psychosocial burden for those who suffer them. A number of studies have considered issues such as a lower quality of life, increased anxiety, depression, suicidal ideation and other psychological disorders(1-3) . However, adequate means for evaluating social interaction difficulties, diminished social networks, and the impoverished conversational exchanges that affect the wellbeing and mental health of the individual have not been sufficiently developed. This article is protected by copyright...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29133556/interspecies-transmission-of-the-blaoxa-48-gene-from-klebsiella-pneumoniae-high-risk-clone-st147-to-different-escherichia-coli-clones-in-the-gut-microbiota
#9
Carmen Potel, Adriana Ortega, Lucía Martínez-Lamas, Verónica Bautista, Benito Regueiro, Jesús Oteo
OXA-48-producing K. pneumoniae (OXA-Kpn) have quickly spread in Spain and other European countries (1).….
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29130739/trans-umbilical-laparoscopic-assisted-appendectomy-in-the-pediatric-population-comparing-single-incision-and-2-trocar-techniques
#10
Mariana Borges-Dias, Leonor Carmo, Ruben Lamas-Pinheiro, Tiago Henriques-Coelho, José Estevão-Costa
INTRODUCTION: Trans-umbilical laparoscopic-assisted appendectomy (TULAA) combines advantages of open surgery with benefits of laparoscopy and can be performed either by single-incision or with two trocars; the present study aims to compare outcomes and cost of these techniques in a pediatric serie. MATERIAL AND METHODS: Patients undergoing TULAA between July 2013 and June 2014 were retrospectively reviewed. There were two groups: A (single-incision) - one umbilical trocar for a telescope with inbuilt working channel; and B (2-trocar) - one umbilical trocar for a 'standard' telescope plus a supra-pubic trocar for instruments...
November 13, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29128176/back-so-soon-is-early-recurrence-of-papillary-thyroid-cancer-really-just-persistent-disease
#11
Maria F Bates, Marcos R Lamas, Reese W Randle, Kristin L Long, Susan C Pitt, David F Schneider, Rebecca S Sippel
BACKGROUND: Papillary thyroid carcinoma has excellent survival, yet recurrence remains a challenge. We sought to determine the proportion of reoperations performed for persistent, rather than truly recurrent, disease. METHODS: We conducted a retrospective review of a prospectively maintained database. Patients with papillary thyroid carcinoma who underwent reoperation for disease from 2000-2016 were included. We defined recurrence as disease that developed after a patient had an undetectable thyroglobulin and a negative ultrasonography within 1 year of operation...
November 8, 2017: Surgery
https://www.readbyqxmd.com/read/29124477/correction-to-drug-delivery-from-an-innovative-lama-laba-co-suspension-delivery-technology-fixed-dose-combination-mdi-evidence-of-consistency-robustness-and-reliability
#12
Amber Doty, Jon Schroeder, Kou Vang, Mark Sommerville, Mervin Taylor, Brad Flynn, David Lechuga-Ballesteros, Peter Mack
This article was originally published Online First without open access. After publication it was discovered that the author had ordered open access during the production process. The incorrect license was assigned to this paper due to a technical error.
November 9, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29120273/triple-therapy-in-copd-what-we-know-and-what-we-don-t
#13
Peter M A Calverley, Helgo Magnussen, Marc Miravitlles, Jadwiga A Wedzicha
Triple inhaled therapy for chronic obstructive pulmonary disease (COPD) consists of an inhaled corticosteroid (ICS), a long-acting β2-agonist (LABA) and a long-acting muscarinic antagonist (LAMA) taken in combination. Triple therapy is recommended by the Global initiative for Chronic Obstructive Lung Disease (GOLD) for patients who experience recurrent exacerbations despite treatment with either a dual bronchodilator (preferred initial therapy) or LABA/ICS combination (alternative initial therapy). Although there is evidence for the greater efficacy of triple therapy compared with LABA/ICS and LAMA monotherapy with regards to improved lung function, health status, and exacerbation rate, the efficacy of triple therapy when compared with dual bronchodilation (LABA/LAMA) is as yet unknown...
November 9, 2017: COPD
https://www.readbyqxmd.com/read/29119473/preference-of-oral-tenofovir-disoproxil-fumarate-emtricitabine-versus-rectal-tenofovir-reduced-glycerin-1-gel-regimens-for-hiv-prevention-among-cisgender-men-and-transgender-women-who-engage-in-receptive-anal-intercourse-with-men
#14
Alex Carballo-Diéguez, Rebecca Giguere, Curtis Dolezal, Cheng-Shiun Leu, Iván C Balán, William Brown, Christine Rael, Barbra A Richardson, Jeanna M Piper, Linda-Gail Bekker, Suwat Chariyalertsak, Anupong Chitwarakorn, Pedro Gonzales, Timothy H Holtz, Albert Liu, Kenneth H Mayer, Carmen D Zorrilla, Javier R Lama, Ian McGowan, Ross D Cranston
Oral pre-exposure prophylaxis (PrEP) can prevent HIV transmission. Yet, some may prefer not to take systemic daily medication. MTN-017 was a 3-period, phase 2 safety and acceptability study of microbicide gel applied rectally either daily or before and after receptive anal intercourse (RAI), compared to daily oral tablet. At baseline, cisgender men and transgender women who reported RAI (N = 187) rated the daily oral regimen higher in overall liking, ease of use, and likelihood of future use than the gel regimens...
November 8, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29116901/use-of-ics-in-copd-from-blockbuster-medicine-to-precision-medicine
#15
Marco Contoli, Angelo G Corsico, Pierachille Santus, Fabiano Di Marco, Fulvio Braido, Paola Rogliani, Luigi Calzetta, Nicola Scichilone
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, whose burden is expected to increase in the next decades, because of numerous risk factors, including the aging of the population. COPD is both preventable and treatable by an effective management including risk factor reduction, prevention, assessment, and treatment of acute exacerbations and co-morbidities. The available agents approved for COPD treatment are long-acting or ultra-long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) bronchodilators, as well as inhaled corticosteroids (ICS) in combination with LABAs...
November 8, 2017: COPD
https://www.readbyqxmd.com/read/29115881/a-review-of-current-and-developing-fixed-dose-laba-lama-combinations-for-treating-copd
#16
Chitra Lal, Charlie Strange
The current GOLD (Global Initiative for Chronic Obstructive Lung Disease) recommendations suggest using long acting β2 agonists (LABA) and long acting muscarinic antagonists (LAMA) in combination for group B COPD patients with persistent symptoms, group C COPD patients with further exacerbations on LAMA therapy alone and for group D COPD patients with or without combination with inhaled corticosteroids (ICS). Thus, there is a lot of interest in developing LABA/LAMA combinations for maintenance therapy of chronic stable COPD...
November 8, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29112494/proposal-for-the-creation-of-a-national-strategy-for-precision-medicine-in-cancer-a-position-statement-of-seom-seap-and-sefh
#17
Pilar Garrido, Azucena Aldaz, Miguel Ángel Calleja, Enrique De Álava, María Jesús Lamas, Miguel Martín, Xavier Matías-Guiu, José Palacios, Ruth Vera
Precision medicine is an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person. Precision medicine is transforming clinical and biomedical research, as well as health care itself from a conceptual, as well as a methodological viewpoint, providing extraordinary opportunities to improve public health and lower the costs of the healthcare system. However, the implementation of precision medicine poses ethical-legal, regulatory, organizational and knowledge-related challenges...
November 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29112493/-cysteamine-ophthalmic-hydrogel-for-the-treatment-of-ocular-cystinosis
#18
Anxo Fernández-Ferreiro, Andrea Luaces-Rodríguez, Victoria Díaz-Tomé, María Gil-Martínez, María Teresa Rodríguez Ares, Rosario Touriño Peralba, José Blanco-Méndez, Miguel González-Barcia, Francisco Javier Otero-Espinar, María Jesús Lamas
Ocular cystinosis is a rare disease characterised by the deposit of cystine crystals on the corneal surface, which hinder patients' eyesight. Oral cysteamine is given as cysteamine; however, it does not reach the cornea due to the lack of corneal vascularization making necessary its  administration by the topical ocular route. The aim of the present study is to  determine the stability of an ophthalmic hydrogel of cysteamine, which can be  potentially prepared at hospital pharmacy departments, under different preservation conditions during a follow-up of 30 days...
November 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29107820/audiovisual-integration-increases-the-intentional-step-synchronization-of-side-by-side-walkers
#19
Dominic Noy, Sandra Mouta, Joao Lamas, Daniel Basso, Carlos Silva, Jorge A Santos
When people walk side-by-side, they often synchronize their steps. To achieve this, individuals might cross-modally match audiovisual signals from the movements of the partner and kinesthetic, cutaneous, visual and auditory signals from their own movements. Because signals from different sensory systems are processed with noise and asynchronously, the challenge of the CNS is to derive the best estimate based on this conflicting information. This is currently thought to be done by a mechanism operating as a Maximum Likelihood Estimator (MLE)...
November 3, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29107648/corrigendum-to-european-contribution-to-the-study-of-ros-a-summary-of-the-findings-and-prospects-for-the-future-from-the-cost-action-bm1203-eu-ros-redox-biol-13-2017-94-162
#20
J Egea, I Fabregat, Y M Frapart, P Ghezzi, A Görlach, T Kietzmann, K Kubaichuk, U G Knaus, M G Lopez, G Olaso-Gonzalez, A Petry, R Schulz, J Vina, P Winyard, K Abbas, O S Ademowo, C B Afonso, I Andreadou, H Antelmann, F Antunes, M Aslan, M M Bachschmid, R M Barbosa, V Belousov, C Berndt, D Bernlohr, E Bertrán, A Bindoli, S P Bottari, P M Brito, G Carrara, A I Casas, A Chatzi, N Chondrogianni, M Conrad, M S Cooke, J G Costa, A Cuadrado, P My-Chan Dang, B De Smet, B Debelec-Butuner, I H K Dias, J D Dunn, A J Edson, M El Assar, J El-Benna, P Ferdinandy, A S Fernandes, K E Fladmark, U Förstermann, R Giniatullin, Z Giricz, A Görbe, H Griffiths, V Hampl, A Hanf, J Herget, P Hernansanz-Agustín, M Hillion, J Huang, S Ilikay, P Jansen-Dürr, V Jaquet, J A Joles, B Kalyanaraman, D Kaminskyy, M Karbaschi, M Kleanthous, L O Klotz, B Korac, K S Korkmaz, R Koziel, D Kračun, K H Krause, V Křen, T Krieg, J Laranjinha, A Lazou, H Li, A Martínez-Ruiz, R Matsui, G J McBean, S P Meredith, J Messens, V Miguel, Y Mikhed, I Milisav, L Milković, A Miranda-Vizuete, M Mojović, M Monsalve, P A Mouthuy, J Mulvey, T Münzel, V Muzykantov, I T N Nguyen, M Oelze, N G Oliveira, C M Palmeira, N Papaevgeniou, A Pavićević, B Pedre, F Peyrot, M Phylactides, G G Pircalabioru, A R Pitt, H E Poulsen, I Prieto, M P Rigobello, N Robledinos-Antón, L Rodríguez-Mañas, A P Rolo, F Rousset, T Ruskovska, N Saraiva, S Sasson, K Schröder, K Semen, T Seredenina, A Shakirzyanova, G L Smith, T Soldati, B C Sousa, C M Spickett, A Stancic, M J Stasia, H Steinbrenner, V Stepanić, S Steven, K Tokatlidis, E Tuncay, B Turan, F Ursini, J Vacek, O Vajnerova, K Valentová, F Van Breusegem, L Varisli, E A Veal, A S Yalçın, O Yelisyeyeva, N Žarković, M Zatloukalová, J Zielonka, R M Touyz, A Papapetropoulos, T Grune, S Lamas, H H H W Schmidt, F Di Lisa, A Daiber
No abstract text is available yet for this article.
October 26, 2017: Redox Biology
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