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https://www.readbyqxmd.com/read/28100244/is-aclidinium-alone-or-combined-with-a-laba-a-rational-choice-for-symptomatic-copd-patients
#1
REVIEW
F Blasi, G W Canonica, M Miravitlles
BACKGROUND: As emphasized by international recommendations and largely confirmed by clinical experience, long-acting bronchodilators play a central role in the maintenance treatment of chronic obstructive pulmonary disease (COPD) due to their proven efficacy in reducing airflow obstruction and improving symptoms. MAIN BODY: There are some important aspects to define with regard to inhalation therapy for COPD, particularly those concerning the selection criteria and the optimal use of long-acting bronchodilators...
January 18, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28099820/new-and-developing-non-adrenoreceptor-small-molecule-drugs-for-the-treatment-of-asthma
#2
Neil C Thomson
Introduction Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma. Additional drugs include leukotriene-receptor antagonists, slow-release theophylline and the long-acting muscarinic antagonist (LAMA) tiotropium (approved in 2015). There is a need for more effective therapies, as many patients continue to have poorly controlled asthma. Areas covered New and developing long-acting non-adrenoreceptor synthetic drugs for the treatment of symptomatic chronic asthma despite treatment with an ICS alone or combined with a LABA...
January 18, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28099612/tinea-faciei-on-the-right-eyebrow-caused-by-trichophyton-interdigitale
#3
Kai Wen Zhuang, Ya Ling Dai, Yu Ping Ran, Jebina Lama, Yi Ming Fan
Tinea faciei is a relatively uncommon dermatophyte infection entailing atypical clinical symptoms, usually misdiagnosed and treated with corticosteroids. The authors describe a case of tinea faciei on the right eyebrow caused by Trichophyton interdigitale. The patient was an 18-year-old girl, who had an inflammatory plaque with a scaly, pustular surface on the right eyebrow and upper eyelid, which had persisted for over 1 month. She was once misdiagnosed as having eczema and was treated using corticosteroid cream...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28099043/validation-of-the-arabic-version-of-the-infant-feeding-intentions-scale-among-lebanese-women
#4
Nadine Yehya, Hani Tamim, Lama Shamsedine, Soumaya Ayash, Lama Abdel Khalek, Amanda Abou Ezzi, Mona Nabulsi
BACKGROUND: The Infant Feeding Intentions (IFI) scale was shown to reliably measure maternal intentions to initiate breastfeeding and continue exclusive breastfeeding until 1, 3, or 6 months in English and Spanish but not in Arab contexts. Research aim: This study aimed to validate an Arabic version of the IFI scale (IFI-A) and examine its ability to predict exclusive breastfeeding at 1, 3, or 6 months in pregnant Lebanese women. METHODS: The internal consistency reliability and construct validity of the IFI-A scale were tested on 50 pregnant women (Group 1), whereas its predictive ability was tested on 196 pregnant women (Group 2), who were surveyed monthly about their infants' nutrition method until 6 months...
January 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28096283/laba-lama-combination-in-copd-a-meta-analysis-on-the-duration-of-treatment
#5
REVIEW
Luigino Calzetta, Paola Rogliani, Josuel Ora, Ermanno Puxeddu, Mario Cazzola, Maria Gabriella Matera
When there are no randomised clinical trials directly comparing all relevant treatment options, an indirect treatment comparison via meta-analysis of the available clinical evidence is an acceptable alternative. However, meta-analyses may be very misleading if not adequately performed. Here, we propose and validate a simple and effective approach to meta-analysis for exploring the effectiveness of long-acting β2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) fixed-dose combinations in chronic obstructive pulmonary disease...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28089081/asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome-literature-review-and-contributions-towards-a-portuguese-consensus
#6
D Araújo, E Padrão, M Morais-Almeida, J Cardoso, F Pavão, R B Leite, A C Caldas, A Marques
INTRODUCTION: Phenotypic overlap between the two main chronic airway pulmonary diseases, asthma and chronic obstructive pulmonary disease (COPD), has been the subject of debate for decades, and recently the nomenclature of asthma-COPD overlap syndrome (ACOS) was adopted for this condition. The definition of this entity in the literature is, however, very heterogeneous, it is therefore important to define how it applies to Portugal. METHODS: A literature review of ACOS was made in a first phase resulting in the drawing up of a document that was later submitted for discussion among a panel of chronic lung diseases experts, resulting in reflexions about diagnosis, treatment and clinical guidance for ACOS patients...
January 6, 2017: Revista Portuguesa de Pneumologia
https://www.readbyqxmd.com/read/28088173/high-risk-human-papillomavirus-infection-and-abnormal-cervical-cytology-among-nepali-and-bhutanese-refugee-women-living-in-eastern-nepal
#7
Madhav P Bhatta, Derek C Johnson, Mingma Lama, Shilu Aryal, Pema Lhaki, Sadeep Shrestha
BACKGROUND: Cervical cancer is the leading cause of cancer morbidity and mortality among women in Nepal and Bhutan. Data on high-risk human papillomavirus (HR-HPV) infection and cervical abnormalities among Nepali and Bhutanese women are sparse. The objectives of this study were to assess and compare the prevalence of HR-HPV infection and cervical abnormalities among Nepali and Bhutanese women living in Jhapa District in eastern Nepal; and examine the risk factors for HR-HPV infection and cervical abnormalities in those women...
January 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28077750/the-association-between-neurocysticercosis-and-hippocampal-atrophy-is-related-to-age
#8
Oscar H Del Brutto, Naoum P Issa, Perla Salgado, Victor J Del Brutto, Mauricio Zambrano, Julio Lama, Héctor H García
Neurocysticercosis (NCC) has been associated with hippocampal atrophy, but the prevalence and pathogenic mechanisms implicated in this relationship are unknown. Using a population-based, case-control study design, residents in a rural village (Atahualpa) aged ≥ 40 years with calcified NCC were identified as cases and paired to NCC-free individuals (control subjects) matched by age, sex, and level of education. Cases and control subjects underwent magnetic resonance imaging for hippocampal rating according to the Scheltens' scale for medial temporal atrophy and were interviewed to identify those with a clinical seizure disorder...
January 11, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28070299/evaluating-citizen-science-data-for-forecasting-species-responses-to-national-forest-management
#9
Louise Mair, Philip J Harrison, Mari Jönsson, Swantje Löbel, Jenni Nordén, Juha Siitonen, Tomas Lämås, Anders Lundström, Tord Snäll
The extensive spatial and temporal coverage of many citizen science datasets (CSD) makes them appealing for use in species distribution modeling and forecasting. However, a frequent limitation is the inability to validate results. Here, we aim to assess the reliability of CSD for forecasting species occurrence in response to national forest management projections (representing 160,366 km(2)) by comparison against forecasts from a model based on systematically collected colonization-extinction data. We fitted species distribution models using citizen science observations of an old-forest indicator fungus Phellinus ferrugineofuscus...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28063813/assessment-of-vascular-function-in-low-socioeconomic-status-preschool-children-a-pilot-study
#10
Lama Ghazi, Tanja Dudenbostel, Daisy Xing, Deborah Ejem, Anne Turner-Henson, Cynthia Irwin Joiner, Olivia Affuso, Andres Azuero, Suzanne Oparil, David A Calhoun, Marti Rice, Fadi G Hage
Elevated brachial blood pressure (BP) in childhood tracks into adulthood. Central BP and measures of arterial stiffness, such as aortic augmentation index (AIx) and pulse wave velocity (PWV), have been associated with future cardiovascular disease. This pilot study assessed the feasibility of noninvasively measuring these parameters in preschool children and explored factors that may be associated with elevated BP in this age group. Brachial BP was measured using an electronic oscillometric unit (Dinamap PRO 100) and defined as elevated when systolic BP (SBP) and/or diastolic BP (DBP) was ≥ the 90th percentile for age, gender, and height...
December 24, 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28062314/sexually-acquired-zika-virus-a-systematic-review
#11
REVIEW
José Moreira, Thiago M Peixoto, André Machado de Siqueira, Cristiane C Lamas
BACKGROUND: Zika virus (ZIKV) is transmitted to humans primarily by Aedes mosquito bites. However, circumstantial evidence points to a sexual transmission route. OBJECTIVES: To assess the sexually-acquired ZIKV cases and to investigate the shedding of ZIKV in genital fluids. DATA SOURCES: PubMed, Scopus, Pro-MED-mail, and WHO ZIKV notification databases from inception to December 2016. SELECTION CRITERIA: Reports describing ZIKV acquisition through sex and studies reporting the detection or isolation of ZIKV in the genital fluids were included...
January 3, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28057707/an-update-on-lama-laba-combinations-for-copd
#12
(no author information available yet)
The management of symptoms of chronic obstructive pulmonary disease (COPD) typically involves the use of inhaled long-acting bronchodilators. Previously, we have reviewed the long-acting muscarinic antagonists (LAMAs) ▼aclidinium,(1) ▼glycopyrronium,(2) tiotropium(3) and ▼umeclidinium,(4) and the long-acting beta2 agonists (LABAs) indacaterol,(5) ▼olodaterol,(6) and ▼vilanterol (in combination with fluticasone) in the management of COPD.(7) Four fixed-dose combinations of a LAMA with a LABA are now available, all indicated as maintenance bronchodilator treatment to relieve symptoms in adult patients with COPD...
January 5, 2017: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/28056724/knowledge-and-preferences-concerning-acute-hiv-testing-programs-among-both-peruvian-men-who-have-sex-with-men-and-transgender-women
#13
Grace M Wandell, Yamile Molina, Hugo Sánchez, Anna C Greer, Jessica Ríos, Carolyn Bain, Patricia Segura, Javier R Lama, Jorge Sánchez, Ann Duerr
Immediate antiretroviral therapy (ART) for acute HIV infection (AHI) may decrease HIV transmission in high-risk populations. This study evaluated knowledge of AHI and AHI testing program preferences in Lima, Peru through four semi-structured focus groups with high-risk men who have sex with men (MSM) ( n = 20) and transgender women (TW) ( n = 16). Using content analysis, emergent themes included knowledge of AHI symptoms, AHI transmission potential, and the HIV testing window period, and preferences concerning point of care results...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28050979/assessment-of-the-pubertal-growth-period-using-the-open-apices-of-the-lower-teeth
#14
Yousef N Issa, Ahmad S Burhan, Fehmieh R Nawaya, Lama G Massouh
AIM: The purpose of this study was to evaluate whether the open apex measurements of the lower teeth can be used for prediction of the pubertal growth spurt. MATERIALS AND METHODS: The study group consisted of 150 males and 142 females ranging in age from 10 to 16 years. A total of 292 panoramic and 292 hand-wrist radiographs were obtained and analyzed. The skeletal maturity was determined according to the skeletal maturity indicators (SMIs) developed by Fishman...
January 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28045651/pharmacotherapy-follow-up-of-patients-under-treatment-with-biologic-agents-for-chronic-inflammatory-systemic-conditions-an-agreement-among-hospital-pharmacists-for-the-standardized-collection-of-a-minimum-set-of-data
#15
Miguel Ángel Calleja Hernández, Alicia Herrero Ambrosio, María Jesús Lamas Díaz, Julio Martínez Cutillas, Jose Luis Poveda Andrés, Belén Aragón
BACKGROUND AND OBJECTIVE: The objective of this study was to reach a consensus on the minimum set of data that would allow to optimize the pharmacotherapy follow-up of patients on biologic agents for chronic systemic inflammatory conditions, through structured and standardized collection with an electronic tool in the hospital pharmacy. MATERIALS AND METHOD: A scientific committee was formed (n = 5 hospital pharmacists). The Delphi Technique was used, 2 rounds of consultation by e-mail for hospital pharmacists...
January 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28043861/the-importance-of-the-hypothalamo-pituitary-adrenal-axis-as-a-therapeutic-target-in-anorexia-nervosa
#16
REVIEW
Rami Bou Khalil, Lama Souaiby, Nassim Farès
Anorexia nervosa (AN) is an eating disorder, mainly affecting women, with a lifetime prevalence of about 1%, that can run a chronic course. While an effective pharmacotherapy is lacking, it is hypothesized that the progesterone and type II glucocorticoid receptor antagonist mifepristone (RU486) might be useful, as it is well known that the hypothalamo-pituitary-adrenal axis (HPA) is activated in AN. Even if secondary to the eating disorder, an active HPA axis may contribute to maintaining the neuroendocrine, emotional and behavioral effects observed in AN...
December 30, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28039304/allergen-valency-dose-and-fc%C3%AE%C2%B5ri-occupancy-set-thresholds-for-secretory-responses-to-pen-a-1-and-motivate-design-of-hypoallergens
#17
Avanika Mahajan, Lama A Youssef, Cédric Cleyrat, Rachel Grattan, Shayna R Lucero, Christopher P Mattison, M Frank Erasmus, Bruna Jacobson, Lydia Tapia, William S Hlavacek, Mark Schuyler, Bridget S Wilson
Ag-mediated crosslinking of IgE-FcεRI complexes activates mast cells and basophils, initiating the allergic response. Of 34 donors recruited having self-reported shrimp allergy, only 35% had significant levels of shrimp-specific IgE in serum and measurable basophil secretory responses to rPen a 1 (shrimp tropomyosin). We report that degranulation is linked to the number of FcεRI occupied with allergen-specific IgE, as well as the dose and valency of Pen a 1. Using clustered regularly interspaced palindromic repeat-based gene editing, human RBL(rαKO) cells were created that exclusively express the human FcεRIα subunit...
December 30, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28034706/vagal-and-recurrent-laryngeal-nerves-neuromonitoring-during-thyroidectomy-and-parathyroidectomy-a-prospective-study
#18
N Julien, E Ferrary, A Sokoloff, G Lamas, O Sterkers, D Bernadeschi
OBJECTIVES: The aim of the study was to stimulate the vagal and the recurrent laryngeal nerves during and after thyroidectomy or parathyroidectomy, to record muscle responses, interpret the electrophysiological modifications and identify prognostic factors for postoperative vocal fold mobility. PATIENTS AND METHODS: A prospective study monitored 151 vagal nerves and 144 recurrent laryngeal nerves in 114 patients. Seven patients (14 vagal nerves) underwent continuous monitoring via an automatic periodic stimulation (APS(®)) electrode...
December 26, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28032876/evaluaci%C3%A3-n-de-las-evidencias-y-calidad-de-las-gu%C3%A3-as-de-pr%C3%A3-ctica-cl%C3%A3-nica-sobre-deterioro-de-la-integridad-cut%C3%A3-nea-%C3%A3%C2%BAlceras-y-heridas-cr%C3%A3-nicas
#19
J M Rumbo Prieto, M Romero Martín, D Bellido Guerrero, L Arantón Areosa, C D Raña Lama, F Palomar Llatas
Fundamento. La situación epidemiológica, sociosanitaria y económica que rodea al deterioro de la integridad cutánea supone un gran problema para el sistema sanitario. Su prevención y tratamiento crea incertidumbre y variabilidad profesional siendo prioritario contar con buenas Guías de Práctica Clínica (GPC). El objetivo fue conocer la calidad de las GPC sobre prevención y tratamiento de úlceras por presión (UPP), úlceras venosas de la pierna (UVP) y úlceras de pie diabético (UPD). Metodología...
December 30, 2016: Anales del Sistema Sanitario de Navarra
https://www.readbyqxmd.com/read/28029671/prescribing-skills-of-first-and-second-year-mbbs-students-of-a-teaching-hospital
#20
K Chapagain, B D Paranjape, G Lama
INTRODUCTION: To ensure safe, effective and rational prescribing by tomorrow's doctors it is important to assess the prescribing skills of today's medical students. The aim of this study was to assess the prescribing skills of MBBS preclinical students of a Teaching Hospital. METHODS: First and second year medical students were given different sets of common clinical scenarios and asked to write a prescription for these. The physician and drug related components were analyzed following the WHO guidelines...
October 2016: JNMA; Journal of the Nepal Medical Association
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