keyword
https://read.qxmd.com/read/35396146/suprapancreatic-nodal-dissection-should-not-be-uniformly-selected-in-additional-gastrectomy-for-the-patients-who-diagnosed-as-pt1b-gastric-cancer-by-endoscopic-resection
#21
JOURNAL ARTICLE
Tsutomu Hayashi, Takaki Yoshikawa, Kenichi Ishizu, Mai Tsutsui, Takayuki Wada, Yukinori Yamagata, Hitoshi Katai
BACKGROUND: Surgery for T1b gastric cancer requires suprapancreatic nodes (SPA nodes) and perigastric nodes (PG nodes), however, SPA nodal dissection can cause pancreatic complications. If endoscopic treatment followed by additional surgery is planned, it may be possible to predict SPA nodal metastasis by analyzing the pathological information of the primary tumor in addition to the clinical findings. METHODS: Patients who underwent D1+ or D2 and who were pathologically diagnosed with pT1b were retrospectively analyzed...
August 2022: European Journal of Surgical Oncology
https://read.qxmd.com/read/34996481/prognostic-factors-for-elderly-gastric-cancer-patients-who-underwent-gastrectomy
#22
JOURNAL ARTICLE
Shunji Endo, Tomoki Yamatsuji, Yoshinori Fujiwara, Masaharu Higashida, Hisako Kubota, Hideo Matsumoto, Hironori Tanaka, Toshimasa Okada, Kazuhiko Yoshimatsu, Ken Sugimoto, Tomio Ueno
BACKGROUND: Patients with gastric cancer are aging in Japan. It is not clear which patients and which surgical procedures have survival benefits after gastrectomy. A multivariate analysis was performed. METHODS: The medical records of 166 patients aged ≥ 80 years who underwent gastrectomy without macroscopic residual tumors were retrospectively reviewed. Univariate and multivariate analyses using Cox proportional hazard models were performed to detect prognostic factors for overall survival...
January 7, 2022: World Journal of Surgical Oncology
https://read.qxmd.com/read/34837993/the-risk-of-lymph-node-metastasis-in-gastric-cancer-conforming-to-indications-of-endoscopic-resection-and-pylorus-preserving-gastrectomy-a-single-center-retrospective-study
#23
JOURNAL ARTICLE
Wu Yanzhang, Li Guanghua, Zhou Zhihao, Wang Zhixiong, Wang Zhao
BACKGROUND: Lymph node metastasis (LNM) status is an important prognostic factor that strongly influences the treatment decision of early gastric cancer (EGC). This study aimed to evaluate the pattern and clinical significance of LNM in EGC. METHODS: A total of 354 patients with carcinoma in situ (n = 42), EGC (n = 312) who underwent radical gastrectomy were enrolled. Their clinicopathological features, pathological reports, and prognostic data were collected and analyzed...
November 27, 2021: BMC Cancer
https://read.qxmd.com/read/34721783/efficacy-and-toxicity-of-capecitabine-combined-with-intensity-modulated-radiotherapy-after-d1-d2-lymph-node-dissection-in-patients-with-gastric-cancer
#24
JOURNAL ARTICLE
Xin Wang, Wei-Hu Wang, Shu-Lian Wang, Yong-Wen Song, Yue-Ping Liu, Yuan Tang, Ning Li, Wen-Yang Liu, Hui Fang, Ye-Xiong Li, Dong-Bing Zhao, Yihebali Chi, Lin Yang, Jing Jin
BACKGROUND: Adjuvant chemoradiotherapy (ACRT) with oral capecitabine and intensity-modulated radiotherapy (IMRT) were well tolerated in a phase I study in patients who had undergone partial or total gastrectomy for locally advanced gastric cancer (GC). This phase II study aimed to further determine the efficacy and toxicity of this combination after radical resection and D1/D2 lymph node dissection (LND) for patients with locally advanced GC. AIM: To further determine the efficacy and toxicity of this combination after radical resection and D1/D2 LND for patients with locally advanced GC...
October 15, 2021: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/34543741/clinical-implications-of-indocyanine-green-fluorescence-imaging-guided-laparoscopic-lymphadenectomy-for-patients-with-gastric-cancer-a-cohort-study-from-two-randomized-controlled-trials-using-individual-patient-data
#25
RANDOMIZED CONTROLLED TRIAL
Qing Zhong, Qi-Yue Chen, Xiao-Bo Huang, Guang-Tan Lin, Zhi-Yu Liu, Jun-Yu Chen, Hua-Gen Wang, Kai Weng, Ping Li, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Mi Lin, Ze-Ning Huang, Chao-Hui Zheng, Chang-Ming Huang
BACKGROUND: The value of indocyanine green (ICG) fluorescence imaging in tracing metastatic lymph nodes (LNs) has rarely been reported. We aimed to evaluate the clinical implications of fluorescence imaging-guided lymphadenectomy and the sensitivity of fluorescent lymphography to detect metastatic LN stations in gastric cancer (GC). MATERIALS AND METHODS: This analysis pooled data from two randomized controlled trials (FUGES-012 and FUGES-019 studies) on laparoscopic ICG tracer-guided lymphadenectomy for GC between November 2018 and October 2020...
October 2021: International Journal of Surgery
https://read.qxmd.com/read/34313862/single-incision-plus-one-port-laparoscopic-gastrectomy-versus-conventional-multi-port-laparoscopy-assisted-gastrectomy-for-gastric-cancer-a-retrospective-study
#26
JOURNAL ARTICLE
Guang-Sheng Du, En-Lai Jiang, Yuan Qiu, Wen-Sheng Wang, Jiu-Heng Yin, Shuai Wang, Yun-Bo Li, Yi-Hui Chen, Hua Yang, Wei-Dong Xiao
BACKGROUND: We compared short-term perioperative outcomes after single-incision plus one-port laparoscopic gastrectomy (SILG+1) and conventional multi-port laparoscopy-assisted gastrectomy (C-LAG) for gastric cancer. METHODS: The work was conducted between August 2017 and October 2019. A total of 90 patients with early or advanced gastric cancer were retrospectively analyzed: 43 patients of which underwent SILG+1, and 47 of which underwent C-LAG, respectively. These were divided into two groups: the total gastrectomy group (SILT+1 and C-LATG) and the distal gastrectomy group (SILD + 1 and C-LADG)...
May 2022: Surgical Endoscopy
https://read.qxmd.com/read/34150106/analysis-on-the-application-value-of-goal-directed-fluid-therapy-in-patients-undergoing-laparoscopy-assisted-radical-gastrectomy-with-fast-track-anesthesia
#27
JOURNAL ARTICLE
Aiping Tang, Shuying Zhou
OBJECTIVE: To explore the application value of goal-directed fluid therapy (GDFT) in patients undergoing laparoscopy-assisted radical gastrectomy with fast-track anesthesia. METHODS: From December 2016 to December 2019, 74 patients who underwent laparoscopy-assisted radical gastrectomy under the concept of enhanced recovery after surgery (ERAS) in gastrointestinal Surgery department of Tongling People's Hospital were selected as research participants. They were divided into two groups: the routine group (patients were treated with conventional fluids) (n=37) and the GDFT group (patients were treated with GDFT) (n=37)...
2021: American Journal of Translational Research
https://read.qxmd.com/read/33910779/lymph-node-dissection-for-gastric-cancer-establishment-of-d2-and-the-current-position-of-splenectomy-in-europe-and-japan
#28
REVIEW
Z Faiz, T Hayashi, T Yoshikawa
Two European phase III trials comparing D1 and D2 demonstrated that D2 did not improve the overall survival and was associated with a high mortality related to splenectomy. However, a long-term follow-up study showed that the gastric cancer-related death rate was significantly higher in D1 than D2. Based on these findings, the standard surgery in Europe became D2 without pancreatico-splenectomy to prevent mortality. In contrast, the JCOG9501 phase III comparing D2 and D2 plus para-aortic nodal dissection did not showed a survival efficacy of extended lymphadenectomy, but the mortality rate was quite low in both surgeries...
April 21, 2021: European Journal of Surgical Oncology
https://read.qxmd.com/read/33887514/d2-dissection-improves-disease-specific-survival-in-advanced-gastric-cancer-patients-15-year-follow-up-results-of-the-italian-gastric-cancer-study-group-d1-versus-d2-randomised-controlled-trial
#29
RANDOMIZED CONTROLLED TRIAL
M Degiuli, R Reddavid, M Tomatis, A Ponti, M Morino, M Sasako
BACKGROUND: The extended lymphadenectomy (D2) was recently introduced in several guidelines as the optimal treatment for gastric cancer, based only on the 15-year follow-up results of the Dutch randomised trial, while the British Medical Research Council (MRC) study failed to demonstrate a survival benefit over the more limited D1 dissection. The Italian Gastric Cancer Study Group randomised controlled trial (RCT) was also undertaken to compare D1 versus D2 gastrectomy, and a tendency to improve survival in patients with advanced resectable disease (pT > 1N+) was documented despite negative results in the entire patient population...
June 2021: European Journal of Cancer
https://read.qxmd.com/read/33854810/pancreatic-fistula-after-d1-d2-radical-gastrectomy-according-to-the-updated-international-study-group-of-pancreatic-surgery-criteria-risk-factors-and-clinical-consequences-experience-of-surgeons-with-high-caseloads-in-a-single-surgical-center-in-eastern-europe
#30
JOURNAL ARTICLE
Alexandru Martiniuc, Traian Dumitrascu, Mihnea Ionescu, Stefan Tudor, Monica Lacatus, Vlad Herlea, Catalin Vasilescu
Purpose: Incidence, risk factors, and clinical consequences of pancreatic fistula (POPF) after D1+/D2 radical gastrectomy have not been well investigated in Western patients, particularly those from Eastern Europe. Materials and Methods: A total of 358 D1+/D2 radical gastrectomies were performed by surgeons with high caseloads in a single surgical center from 2002 to 2017. A retrospective analysis of data that were prospectively gathered in an electronic database was performed...
March 2021: Journal of Gastric Cancer
https://read.qxmd.com/read/33755967/prognostic-significance-of-palliative-gastrectomy-in-incurable-advanced-gastric-cancer-a-retrospective-cohort-study-and-meta-analysis
#31
JOURNAL ARTICLE
C Zheng, Z-M Gao, H-B Huang, K Li, X-F Liu
OBJECTIVE: There is controversy regarding the role of palliative gastrectomy in patients with incurable advanced gastric cancer requiring surgical intervention. The present retrospective cohort study and meta-analysis aimed to determine whether palliative gastrectomy plus chemotherapy can prolong the survival of patients with incurable advanced gastric cancer requiring surgical intervention. PATIENTS AND METHODS: The data from 153 patients diagnosed with incurable advanced gastric cancer requiring surgical intervention at our institute between January 2000 and December 2012 were retrospectively reviewed...
March 2021: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/33677846/effect-of-preoperative-tumour-under-staging-on-the-long-term-survival-of-patients-undergoing-radical-gastrectomy-for-gastric-cancer
#32
JOURNAL ARTICLE
Mi Lin, Qi-Yue Chen, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Chang-Ming Huang
Purpose: This study aimed to evaluate the effect of preoperative tumour staging deviation (PTSD) on the long-term survival of patients undergoing radical gastrectomy for gastric cancer (RGGC). Materials and Methods: Clinicopathological data of 2 346 patients who underwent RGGC were retrospectively analysed. The preoperative tumour-lymph node-metastasis (TNM) under-staging group (uTNM) comprised patients who had earlier preoperative TNM than postoperative TNM, and the no preoperative under-staging group (nTNM) comprised the remaining patients...
March 5, 2021: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://read.qxmd.com/read/33598873/prognostic-factors-for-cytology-positive-gastric-cancer-a-multicenter-retrospective-analysis
#33
JOURNAL ARTICLE
Shunji Endo, Kazuhiro Nishikawa, Masakazu Ikenaga, Kazumasa Fujitani, Junji Kawada, Tomoki Yamatsuji, Hisako Kubota, Masaharu Higashida, Yoshinori Fujiwara, Tomio Ueno
BACKGROUND: The prognosis of patients with gastric cancer and positive peritoneal lavage cytology is poor, even after gastrectomy. Though the standard therapy for this population is radical gastrectomy followed by S-1 chemotherapy, treatments vary among institutions and eras. We conducted a multicenter retrospective study to investigate the prognostic factors for cytology-positive gastric cancer. METHODS: We reviewed the medical records obtained from 6 institutions, covering 2000-2019...
May 2021: International Journal of Clinical Oncology
https://read.qxmd.com/read/33503112/gastrectomy-in-octogenarians-with-gastric-cancer-is-it-feasible
#34
JOURNAL ARTICLE
Francisco Diogo Almeida Silva, Marina Alessandra Pereira, Marcus Fernando Kodama Pertille Ramos, Ulysses Ribeiro-Junior, Bruno Zilberstein, Ivan Cecconello, Andre Roncon Dias
BACKGROUND: The octogenarian population is expanding worldwide and demand for gastrectomy due to gastric cancer in this population is expected to grow. However, the outcomes of surgery with curative intent in this age group are poorly reported and it is unclear what matters most to survival: age, clinical status, disease´s stage, or the extent of the surgery performed. AIM: Evaluate the results of gastrectomy in octogenarians with gastric cancer and to verify the factors related to survival...
2021: Brazilian Archives of Digestive Surgery: ABCD
https://read.qxmd.com/read/33408057/is-lymph-node-dissection-for-neuroendocrine-carcinoma-of-the-stomach-effective-as-it-is-for-adenocarcinoma
#35
JOURNAL ARTICLE
Yukinori Yamagata, Takaki Yoshikawa, Kenichi Ishizu, Ayako Kamiya, Takeyuki Wada, Tsutomu Hayashi, Sho Otsuki, Hitoshi Katai
BACKGROUND: We evaluated the significance of lymph node dissection for gastric neuroendocrine carcinoma (NEC) by calculating the therapeutic value index for each station. METHODS: This study included 2164 advanced gastric cancer patients (common-type [Common-GC], n = 2125; and gastric NEC [NEC-GC], n = 39). Clinicopathological data were collected, and survival, type of recurrence, and the index for each type of gastrectomy were determined. RESULTS: NEC-GC was characterized by an older population (P = 0...
December 30, 2020: European Journal of Surgical Oncology
https://read.qxmd.com/read/33285738/long-term-oncological-outcomes-of-laparoscopic-gastrectomy-for-grossly-early-gastric-cancer-mimicking-advanced-gastric-cancer-propensity-score-matching-analysis
#36
JOURNAL ARTICLE
Sung Eun Oh, Ji Yeong An, Min-Gew Choi, Tae Sung Sohn, Jae Moon Bae, Jun Ho Lee
Laparoscopic gastrectomy became an option in the treatment of early gastric cancer (EGC) in clinical practice. However, whether laparoscopic surgery for grossly EGC-mimicking advanced gastric cancer (AGC) patients is oncologically safe long-term is still controversial.We retrospectively analyzed 472 patients with AGC who were diagnosed as clinical EGC. Patients received laparoscopic or open gastrectomy with standard lymph node (LN) dissection from January 2007 to February 2015. We used a 1:3 propensity score matching method for the analysis...
December 4, 2020: Medicine (Baltimore)
https://read.qxmd.com/read/33188500/operative-and-oncological-outcomes-after-d2-versus-d1-gastrectomy-of-operable-gastric-cancer-an-observational-study
#37
JOURNAL ARTICLE
Mohamed M Elmessiry, Tarek A El-Fayoumi, Haytham M Fayed, Ahmed A Gebaly, Eman A E Mohamed
BACKGROUND: The optimal surgery for operable gastric carcinoma is still controversial. The aim of the current study was to assess the outcomes of D2 compared with D1 gastrectomy. STUDY: This observational study included 80 patients with operable gastric cancer treated by D2 gastrectomy at Alexandria University Hospital between January 2010 and January 2016. Another 68 patients treated by D1 gastrectomy during the same period were included. Both groups were compared regarding operative mortality, morbidities, tumor recurrence, and 5-year survival rates...
November 13, 2020: Journal of Gastrointestinal Cancer
https://read.qxmd.com/read/32945996/assessment-of-diagnostic-value-of-fluorescent-lymphography-guided-lymphadenectomy-for-gastric-cancer
#38
JOURNAL ARTICLE
Minoa K Jung, Minah Cho, Chul Kyu Roh, Won Jun Seo, Seohee Choi, Taeil Son, Hyoung-Il Kim, Woo Jin Hyung
BACKGROUND: Indocyanine green fluorescent lymphography helps visualize the lymphatic drainage pattern in gastric cancer; however, it is unknown whether fluorescent lymphography visualizes all metastatic lymph nodes. This study aimed to evaluate the sensitivity of fluorescent lymphography to detect metastatic lymph node stations and lymph nodes and the risk of false-negative findings. METHODS: Patients with clinical T1-4a gastric cancer were included. Indocyanine green was peritumorally injected the day prior to surgery by endoscopy...
September 18, 2020: Gastric Cancer
https://read.qxmd.com/read/32919813/oncologic-feasibility-of-d1-gastrectomy-for-patients-with-ct1n1-ct2n0-1-or-ct3n0-gastric-cancer
#39
JOURNAL ARTICLE
Itamoto Kota, Hikage Makoto, Kamiya Satoshi, Tanizawa Yutaka, Bando Etsuro, Terashima Masanori
INTRODUCTION: D2 gastrectomy has shown a survival benefit in patients with highly advanced gastric cancer; however, it remains unclear whether D2 gastrectomy is required for patients with early-stage advanced gastric cancer or early gastric cancer with limited lymph node metastasis. This analysis aimed to clarify the oncologic feasibility of D1+ gastrectomy in patients with cT1N1, cT2N0-1, or cT3N0 gastric cancer. METHODS: This retrospective cohort analysis included 466 patients with cT1N1, cT2N0-1, or cT3N0 gastric cancer who received curative gastrectomy with either D2 or D1+ dissection...
July 27, 2020: European Journal of Surgical Oncology
https://read.qxmd.com/read/32719184/european-single-center-experience-on-356-operated-patients-for-gastric-cancer
#40
JOURNAL ARTICLE
Alfredo Garofalo, Fabio Carboni, Orietta Federici, Manuel Giofrè, Andrea Balla, Mario Valle, Pietro Ursi
AIM: Surgery in association with lymphadenectomy is the treatment of choice for the gastric adenocarcinoma. Aim is to report our experience in the surgical treatment of gastric cancer in a European center. MATERIAL AND METHODS: A prospectively maintained database identified 515 patients. Staging laparoscopy was performed to rule out peritoneal carcinomatosis in suspicious cases. Type of surgery and lymphadenectomy were determined according to the Japanese guidelines and pathological staging according to the TNM classification...
2020: Annali Italiani di Chirurgia
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