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https://www.readbyqxmd.com/read/29475099/andrographolide-derivative-cx-10-ameliorates-dextran-sulphate-sodium-induced-ulcerative-colitis-in-mice-involvement-of-nf-%C3%AE%C2%BAb-and-mapk-signalling-pathways
#1
Zhenfang Gao, Cuicui Yu, Haiyue Liang, Xuekai Wang, Yue Liu, Xin Li, Kai Ji, Hui Xu, Mingyan Yang, Ke Liu, Dong Qi, Huaying Fan
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), which is characterized by chronic intestinal inflammation and leads to an increased risk of colon cancer. There are many studies using phyto-ingredients as a novel approach for the treatment of UC. The plant Andrographis paniculata (Acanthaceae) is a safe and edible vegetable that has been extensively adopted in traditional Chinese medicine for conditions involving inflammation, and the most active phytochemical agent is andrographolide...
February 20, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29474902/chloroform-fraction-of-foeniculum-vulgare-induced-ros-mediated-mitochondria-caspase-dependent-apoptotic-pathway-in-mcf-7-human-breast-cancer-cell-line
#2
Fareeduddin Quadri Syed, Ayman I Elkady, Furkhan Ahmed Mohammed, Muqtadir Baig Mirza, Khalid Rehman Hakeem, Saleh Alkarim
ETHNOPHARMACOLOGICAL RELEVANCE: Foeniculum vulgare Mill. (Fennel) is one of the most common herbs used in alternative medicines for its varied range of bioactivity. In Ecuador (South America), use of fennel in traditional cancer treatment is on record. AIM OF THE STUDY: The objective of the present study was to demonstrate the anti-proliferative and apoptotic effect of chloroform fraction of fennel (CFF) in MCF-7 cells. MATERIALS AND METHODS: Anti-proliferative assay (MTT assay) and colony formation assay was performed to study the growth inhibitory effect of CFF...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29474901/arachidonic-acid-metabonomics-study-for-understanding-therapeutic-mechanism-of-huo-luo-xiao-ling-dan-on-rat-model-of-rheumatoid-arthritis
#3
Nannan Wang, Xiaoning Zhao, Jiaxin Huai, Yiran Li, Congcong Cheng, Kaishun Bi, Ronghua Dai
ETHNOPHARMACOLOGICAL RELEVANCE: Huo Luo Xiao Ling Dan (HLXLD), a traditional Chinese medicine (TCM), is commonly used for the treatment of rheumatoid arthritis (RA). AIM OF THE STUDY: To explore the potential therapeutic mechanism of HLXLD on anti-inflammatory activity. MATERIALS AND METHODS: A metabolomic approach based on UFLC-MS/MS to profile arachidonic acid (AA) metabolic changes was used. The cyclooxygenase (COX) and lipoxygenase (LOX) catalyzed metabolites in plasma were quantified on 7, 14, 21, and 28 days after the rats injected with Complete Freund's adjuvant and orally administrated with HLXLD, methotrexate and dexamethasone in parallel as the positive control drugs...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29474900/hepatoprotective-effect-of-forsythiae-fructuse-water-extract-against-carbon-tetrachloride-induced-liver-fibrosis-in-mice
#4
Yi Zhang, Hui Miao, Hongyu Yan, Yuchen Sheng, Lili Ji
ETHNOPHARMACOLOGICAL RELEVANCE: The fruit of Forsythia suspensa (Thunb.) Vahl, named Forsythiae Fructus (Lian-Qiao), is a well-known traditional Chinese medicine (TCM) used for clearing away heat and toxic material, eliminating the mass and relieving swelling. AIM OF THE STUDY: This study aims to observe the attenuation of the water extract of Forsythiae Fructus (FSE) on carbon tetrachloride (CCl4 )-induced hepatic fibrosis in male C57BL/6 mice. MATERIALS AND METHODS: Hepatic fibrosis was induced in male C57BL/6 mice by intraperitoneal injection with 2ml/kg CCl4 (mixed 1: 3 in olive oil) twice a week for 4 weeks...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29474899/high-altitude-organic-gold-the-production-network-for-ophiocordyceps-sinensis-from-far-western-nepal
#5
Mariève Pouliot, Dipesh Pyakurel, Carsten Smith-Hall
ETHNOPHARMACOLOGICAL RELEVANCE: Ophiocordyceps sinensis (Berk.) G.H.Sung, J.M.Sung, Hywel-Jones & Spatafora, a high altitude Himalayan fungus-caterpillar product found in alpine meadows in China, Bhutan, Nepal, and India, has been used in the Traditional Chinese Medicine system for over 2000 years. Heightened demand in China over the past 15 years, coupled with limited production, has led to a price hike and increased economic importance of harvests to rural households throughout the species' range...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29474889/human-gut-microbiota-and-gastrointestinal-cancer
#6
REVIEW
Changting Meng, Chunmei Bai, Thomas D Brown, Leroy Hood, Qiang Tian
Human gut microbiota play an essential role in both healthy and diseased states of humans. In the past decade, the interactions between microorganisms and tumors have attracted much attention in the efforts understanding various features of the complex microbial communities, as well as the possible mechanisms through which the microbiota are involved in cancer prevention, carcinogenesis, and anti-cancer therapy. A large number of studies have indicated that microbial dysbiosis contributes to cancer susceptibility via multiple pathways...
February 20, 2018: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/29474268/twenty-five-years-of-lamivudine-current-and-future-use-for-the-treatment-of-hiv-1-infection
#7
Romina Quercia, Carlo-Federico Perno, Justin Koteff, Katy Moore, Cynthia McCoig, Marty St Clair, Daniel Kuritzkes
Innovation in medicine is a dynamic, complex, and continuous process that cannot be isolated to a single moment in time. Anniversaries offer opportunities to commemorate crucial discoveries of modern medicine, such as penicillin (1928), polio vaccination (inactivated, 1955; oral, 1961), the surface antigen of the hepatitis B virus (1967), monoclonal antibodies (1975), and the first HIV antiretroviral drugs (zidovudine, 1987). The advent of antiretroviral drugs has had a profound effect on the progress of the epidemiology of HIV infection, transforming a terminal, irreversible disease that caused a global health crisis into a treatable but chronic disease...
February 22, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29474265/global-mental-health-and-schizophrenia
#8
Laura Asher, Abebaw Fekadu, Charlotte Hanlon
PURPOSE OF REVIEW: The aim was to synthesize recent evidence on schizophrenia illness experience and outcomes and models of care in low and middle-income countries (LMICs). RECENT FINDINGS: There is a plurality of explanatory models for psychosis and increasing evidence that context influences experiences of stigma. People with schizophrenia in LMICs are vulnerable to food insecurity, violence and physical health problems, in addition to unmet needs for mental healthcare...
February 22, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29473913/establishment-of-the-volatile-signature-of-wine-based-aromatic-vinegars-subjected-to-maceration
#9
Rosa Perestrelo, Catarina L Silva, Pedro Silva, José S Câmara
The flavoring of vinegars with aromatic fruits and medicinal herbs is a practice with increasing trend mostly in countries with oenological tradition, resulting in a product of improved quality and consumer attractiveness. This study was directed towards the evaluation of the impact of the maceration process on the volatile signature of wine-based aromatic vinegars (WBAVs). The evaluation was performed using solid phase microextraction (SPME) combined with gas chromatography combined with mass spectrometry (GC-MS)...
February 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29473531/diabetic-complications-and-insight-into-antidiabetic-potentialities-of-ethno-medicinal-plants-a-review
#10
Muhammad Bilal, Muhammad Sarfaraz Iqbal, Syed Bilal Shah, Tahir Rasheed, Hafiz M N Iqbal
BACKGROUND: The naturally inspired treatment options for several disease conditions and human-health related disorders such as diabetes mellitus have gained considerable research interest. In this context, naturally occurring plants and herbs with medicinal functionalities have gained special place than ever before in the current medicinal world. OBJECTIVE: The objective of this review is to extend the current knowledge in the clinical field related to the diabetic complications...
February 21, 2018: Recent Patents on Inflammation & Allergy Drug Discovery
https://www.readbyqxmd.com/read/29473364/-discussion-on-several-contents-of-textbook-acupuncture-and-moxibustion-new-century-4th-edition
#11
Kaiyu Tian
The textbook Acupuncture and Moxibustion (New Century 4th Edition) was published by China Press of Traditional Chinese Medicine in August of 2016. The author proposed several discussions in the textbook. The information, including the issue date of China national standard Standardized Manipulations of Acupuncture and Moxibustion , the number of foreign countries where China medical teams were assigned, and the number of acupuncture indications recommended by WHO, was not accurate. The content, including several methods of acupoint location, specification of filiform needles, rotating angle of needle, disinfection of needles and skin, locations and indications of scalp acupuncture, etc...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29473185/spectrum-effect-relationship-between-hplc-fingerprints-and-hypolipidemic-effect-of-curcuma-aromatica
#12
Meiqiong Liu, Youjiao Wu, Shushi Huang, Huagang Liu, Jie Feng
Curcuma aromatica was used as an oriental Traditional Chinese Medicine (TCM), and it is mainly distributed in Guangxi, China. In this study, 10 batches of C. aromatica were collected from different origins in Guangxi. The fingerprints were established by HPLC technique to investigate the quality stability of C. aromatica. Spectrum-effect relationship between HPLC fingerprints and hypolipidemic effect of C. aromatica was assessed by similarity analysis (SA), gray relational analysis (GRA) and multiple linear regression analysis (MLRA)...
February 23, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29473017/roadmap-to-wellness-exploring-live-customized-music-at-the-bedside-for-hospitalized-children
#13
R Serene Perkins, Maura Boyce, Megan C Byrtek, Regina C Ellis, Cindy Hill, Paul S Fitzpatrick, Shaban Demirel
Background: Randomized trials on clinical outcomes of music are conflicting, with few performed in the postoperative pediatric population. We aimed to determine if there was a benefit of a live, customized bedside music delivery program (MyMusicRx® ) for children hospitalized after pediatric surgery. We present our perspective on the utility of music medicine, review others' work in this area, and discuss future directions. Methods: All admitted postsurgical patients aged between 5 and 18 years were considered...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29472858/an-integrated-lipidomics-and-phenotype-study-reveals-protective-effect-and-biochemical-mechanism-of-traditionally-used-alisma-orientale-juzepzuk-in-chronic-kidney-disease
#14
Fang Dou, Hua Miao, Jing-Wen Wang, Lin Chen, Ming Wang, Hua Chen, Ai-Dong Wen, Ying-Yong Zhao
Alisma orientale Juzepzuk (AO) is widely used for various diuretic and nephropathic treatments in traditional Chinese medicines (TCM). In a clinical setting, AO is used as both a lipid-lowering and tubular interstitial fibrosis agent. However, the mechanisms of AO for the treatment of renal interstitial fibrosis and abnormal lipid metabolism are not well-understood. In this study, pharmacological and UPLC-HDMS-based lipidomic approaches were employed to investigate the lipid-lowering and tubular interstitial fibrosis effect of AO on rats with adenine-induced chronic kidney disease (CKD)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29472786/exploration-and-local-utilization-of-medicinal-vegetation-naturally-grown-in-the-deusai-plateau-of-gilgit-pakistan
#15
Kifayat Ullah Khan, Maqarab Shah, Habib Ahmad, Shujaul Mulk Khan, Inayat Ur Rahman, Zafar Iqbal, Raees Khan, Elsayed Fathi Abd Allah, Abdulaziz Abdullah Alqarawi, Abeer Hashem, Abdullah Aldubise
In the study area, the traditional knowledge regarding the uses of local wild medicinal plants for the health care of human and domestic animals is totally in hold of old people. The young ones are unaware about such an indispensable practices. The objective of the current study was to transfer this sort of precious knowledge from old members of the community to young generations in documented form.
February 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29472785/honey-single-food-stuff-comprises-many-drugs
#16
REVIEW
Shahid Ullah Khan, Syed Ishtiaq Anjum, Khaista Rahman, Mohammad Javed Ansari, Wasim Ullah Khan, Sajid Kamal, Baharullah Khattak, Ali Muhammad, Hikmat Ullah Khan
Honey is a natural food item produced by honey bees. Ancient civilizations considered honey as a God gifted prestigious product. Therefore, a huge literature is available regarding honey importance in almost all religions. Physically, honey is a viscous and jelly material having no specific color. Chemically, honey is a complex blend of many organic and inorganic compounds such as sugars, proteins, organic acids, pigments, minerals, and many other elements. Honey use as a therapeutic agent is as old as human civilization itself...
February 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29472781/evaluation-of-traditional-medicinal-plant-cissus-setosa-roxb-vitaceae-for-antiulcer-property
#17
Chinnamaruthu Jayachitra, Senguttuvan Jamuna, Mohammad Ajmal Ali, Subramaniam Paulsamy, Fahad M A Al-Hemaid
Cissus setosa is an indigenous medicinal herb commonly used for the treatment of gastro ulcers. In the current investigation the aerial methanolic extract of C. setosa was investigated for their antiulcer activity using pylorus ligation and ethanol in experimental rats. The extract was administered at the doses of 200 and 400 mg/kg b.w. orally for 3 days. However, higher dose of the extract subsequently reduced gastric ulcer induced aberrations by pylorus ligation (70.05%) and ethanol (78.16%) as judged by their altered biochemical parameters such as free acidity, total acidity, total carbohydrate, total protein and pepsin activity...
February 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29472313/luminal-a-breast-cancer-and-molecular-assays-a-review
#18
REVIEW
Jennifer J Gao, Sandra M Swain
PURPOSE: Chemotherapy has been the historical mainstay of treatment for patients with breast cancer, with immunohistochemical markers and tumor characteristics driving treatment decisions. The discovery of different intrinsic subtypes of breast cancer has advanced the understanding of breast cancer, with gene-based assays shedding further light on tumor behavior and response to treatment. DESIGN: This review focuses on the landscape of the luminal A subtype, its definition based on immunohistochemistry (IHC) and gene assays, the prognostic and predictive value of these assays, guideline recommendations, and treatment implications...
February 22, 2018: Oncologist
https://www.readbyqxmd.com/read/29471996/the-eyes-have-it
#19
Lindsay Machan
The ocular lens is one of the most susceptible structures in the body to radiation damage. Unfortunately, much of the traditional academic and regulatory thinking on thresholds to develop radiation-induced opacities or cataracts has proven to be false. Individual vulnerability to the effects of radiation is extremely variable, largely because each individual is variably genetically equipped to repair the damage caused by radiation. Therefore many people, including some unsuspecting interventional radiologists may have no, or almost no, threshold at all for cataract development after radiation injury...
March 2018: Techniques in Vascular and Interventional Radiology
https://www.readbyqxmd.com/read/29471987/unique-contributions-of-keraleeya-ayurveda-in-pediatric-health-care
#20
REVIEW
Seetha Chandran, K S Dinesh, B J Patgiri, Prasanth Dharmarajan
Childhood is considered as the most important phase in life, which determines the quality of health, well being, learning and behaviour across the lifespan. This may be the reason for giving the foremost position for Balacikitsa among Ashtangas (8 branches) of Ayurveda. The regional growth of indigenous medicine gave significant contribution for the development of primary health care. Kerala has major contribution of many authentic textbooks of Balacikitsa like Arogyakalpadruma, Vaidya Tarakam etc. These are more practically oriented and it can be considered as a physician's quick reference hand book...
February 19, 2018: Journal of Ayurveda and Integrative Medicine
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