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https://www.readbyqxmd.com/read/29908471/searching-for-synergistic-calcium-antagonists-and-novel-therapeutic-regimens-for-coronary-heart-disease-therapy-from-a-traditional-chinese-medicine-suxiao-jiuxin-pill
#1
Wei Lei, Jianan Ni, Xueting Xia, Min Jiang, Gang Bai
Coronary heart disease is a vital cause of morbidity and mortality worldwide, and calcium channel blockers (CCBs) are important drugs that can be used to treat cardiovascular diseases. Suxiao Jiuxin Pill (SX), a traditional Chinese medicine, is widely used as an emergency drug for coronary heart disease therapy. However, understanding its potential mechanism in intracellular calcium concentration ([Ca2+ ]i ) modulation remains a challenge. To identify the active pharmacological ingredients (APIs) and reveal a novel combination therapy for ameliorating cardiovascular diseases, the ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) combined with a dual-luciferase reporter [Ca2+ ]i assay system was applied...
June 8, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29908468/first-report-on-the-pharmacokinetic-profile-of-nimbolide-a-novel-anticancer-agent-in-oral-and-intravenous-administrated-rats-by-lc-ms-method
#2
Shandilya Mahamuni Baira, Amit Khurana, Jaganmohan Somagoni, R Srinivas, Chandraiah Godugu, M V N Kumar Talluri
Nimbolide is a novel, natural compound with promising potential as a drug candidate for anticancer activity. It is isolated from the Indian traditional medicinal plant Azadirachta indica popularly known as neem. The present study was undertaken to explore the oral bioavailability and pharmacokinetic characteristics of nimbolide in rats using the LC/QTOF/MS method. A simple protein precipitation method using acetonitrile was employed for extracting nimbolide from rat plasma. The chromatographic separation of nimbolide and the internal standard (regorafenib) was attained on an Aquity BEH C18 column (100 × 2...
June 2, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29908314/quality-control-of-goji-fruits-of-lycium-barbarum-l-and-l-chinense-mill-a-value-chain-analysis-perspective
#3
Ruyu Yao, Michael Heinrich, Zigui Wang, Caroline S Weckerle
ETHNOPHARMACOLOGICAL RELEVANCE: Goji (fruits of Lycium barbarum L. and L. chinense Mill., Solanaceae) have been used as a traditional food and medicine for hundreds of years in Asian countries and are now consumed globally. Quality of herbal medicines is critical for safe use and has been shown to be affected by value chains. AIM OF THE STUDY: Using a value chain (VC) framework, we aim at understanding the influence of different VC types on goji quality and revenue of stakeholders...
June 13, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29908309/anti-inflammatory-and-antibacterial-effects-of-thymus-sipyleus-boiss-subsp-sipyleus-boiss-var-sipyleus-l-essential-oil-against-rhinosinusitis-pathogens
#4
Fatih Demirci, Nursenem Karaca, Mehmet Tekin, Betül Demirci
Thymus sipyleus BOISS. subsp. sipyleus BOISS. var. sipyleus L. of the Lamiaceae, locally known as thyme scented lemon, which is an endemic taxon collected from Sivas in Anatolia, was investigated in this study due to its folk medicine use against rhinosinusitis. The aromatic characteristics of the plant material gave the idea for the detailed evaluation of the volatiles and essential oil thereof. Consequently, the oil was obtained by Clevenger type hydrodistillation followed by gas chromatography-flame ionization detector (GC-FID) and gas chromatography/mass spectrometry (GC/MS) analyses for phytochemical characterization...
June 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29907156/an-ethnobotanical-survey-of-edible-fungi-in-chuxiong-city-yunnan-china
#5
Dongyang Liu, Hong Cheng, Rainer W Bussmann, Zhiyong Guo, Bo Liu, Chunlin Long
BACKGROUND: Chuxiong, known as "the City of Fungi," is rich in fungal resources and traditional knowledge related to fungal biodiversity. The local environment is an excellent habitat for a wide variety of edible fungi. In addition, the region is home to many ethnic minorities and especially the Yi ethnic group who has a long history for traditionally using fungi as food or medicine. The aims of this review are to provide up-to-date information on the knowledge about, and traditional management of, fungi in this area and give advice on future utilization and conservation...
June 15, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29906747/anti-tumor-and-anti-metastasis-activities-of-honey-bee-larvae-powder-by-suppressing-the-expression-of-ezh2
#6
Masakatsu Kageyama, Kejuan Li, Shuang Sun, Guoqing Xing, Ran Gao, Zhongfang Lei, Zhenya Zhang
Honey bee larvae products have been widely used as traditional daily supplements and complementary medicine for health promotion. However, there is little scientific evidence about their bioactivities. This study was designed to examine the anti-tumor and anti-metastasis effects of honey bee larvae powder (HLP) and explore the underlying mechanism. A subcutaneous transplantation model (murine breast cancer cell 4T1-LUC) and lung metastasis model (murine melanoma cell B16-F10) were established to evaluate the anti-tumor and anti-metastasis effects of HLP...
June 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29906314/gromwell-lithospermum-erythrorhizon-root-extract-protects-against-glycation-and-related-inflammatory-and-oxidative-stress-while-offering-uv-absorption-capability
#7
Kelly M Glynn, Penny Anderson, David J Fast, James Koedam, John F Rebhun, Rodney A Velliquette
Glycation and advanced glycation endproducts (AGE) damage skin which is compounded by AGE-induced oxidative stress and inflammation. Lip and facial skin could be susceptible to glycation damage as they are chronically stressed. As Gromwell (Lithospermum erythrorhizon) root (GR) has an extensive traditional medicine history that includes providing multiple skin benefits, our objective was to determine if GR extract and its base naphthoquinone, shikonin, might protect skin by inhibiting glycation, increasing oxidative defenses, suppressing inflammatory responses, and offering ultraviolet (UV) absorptive potential in lip and facial cosmetic matrices...
June 15, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29904594/towards-precision-medicine-the-application-of-omics-technologies-in-asthma-management
#8
Chiara Scelfo, Carla Galeone, Francesca Bertolini, Marco Caminati, Patrizia Ruggiero, Nicola Facciolongo, Francesco Menzella
Asthma is a chronic obstructive respiratory disease characterised by bronchial inflammation. Its biological and clinical features have been widely explored and a number of pharmacological treatments are currently available. Currently several aspects of asthma pathophysiological background remain unclear, and this is crucial for the traditional asthma phenotype approach as well as for new endotype definition. In this scenario, the identification of new molecular and clinical biomarkers may be helpful in order to better understand the disease, define specific diagnostic tools and highlight relevant novel targets for pharmacology treatments...
2018: F1000Research
https://www.readbyqxmd.com/read/29904575/recent-advances-in-transfusions-in-neonates-infants
#9
REVIEW
Ruchika Goel, Cassandra D Josephson
Transfusions of red blood cells (RBCs), platelets, and plasma are critical therapies for infants and neonates (particularly preterm neonates) in the neonatal intensive care unit, who are the most frequently transfused subpopulation across all ages. Although traditionally a significant gap has existed between the blood utilization and the evidence base essential to adequately guide transfusion practices in infants and neonates, pediatric transfusion medicine is evolving from infancy and gradually coming of age...
2018: F1000Research
https://www.readbyqxmd.com/read/29904406/systematic-review-and-meta-analysis-of-the-efficacy-and-safety-of-biqi-capsule-in-rheumatoid-arthritis-patients
#10
Xiu-Min Chen, Jia-Qi Wu, Qing-Chun Huang, Jian-Yong Zhang, Jian-Hong Pen, Zhi-Sheng Huang, Yong-Liang Chu, Xiao-Hong He, Mao-Jie Wang, Run-Yue Huang
Biqi capsule is a Traditional Chinese Medicine preparation for treating rheumatoid arthritis (RA), and clinical studies have indicatedthat its effect may be more beneficial than that of Western medicine. The present study aimed to estimate the efficacy and safety of Biqi capsule alone or combined with methotrexate (MTX) compared with MTX alone for treating RA by performing a meta-analysis of randomized controlled trials and controlled clinical trials. A systematic literature search of studies published until March 2017 was performed...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29904398/apoptosis-and-antimigration-induction-in-human-skin-cancer-cells-by-rhodomyrtone
#11
Malatee Tayeh, Sirinun Nilwarangkoon, Chantra Tanunyutthawongse, Wilawan Mahabusarakum, Ramida Watanapokasin
Rhodomyrtone is a bioactive compound extracted from Rhodomyrtus tomentosa leaves. It has been used as a traditional herb medicine for many years. Rhodomyrtone exhibits antibacterial activity, anti-inflammatory and antioxidant activities. However, the anticancer activity of rhodomyrtone has not been previously reported. The present study investigated the anticancer effect of rhomyrtone on human epidermoid carcinoma A431 cells. The cytotoxic and antiproliferative effects of rhodomyrtone on A431 cells were investigated by an MTT assay...
June 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29903020/efficacy-and-safety-of-acupuncture-for-functional-constipation-a-randomised-sham-controlled-pilot-trial
#12
Hye-Yoon Lee, Oh-Jin Kwon, Jung-Eun Kim, Mikyeong Kim, Ae-Ran Kim, Hyo-Ju Park, Jung-Hyo Cho, Joo-Hee Kim, Sun-Mi Choi
BACKGROUND: The prevalence of functional constipation (FC) is 3-27%, and FC has been reported to cause discomfort in daily life and various complications. The treatment for FC depends on laxatives, and thus, effective and non-toxic alternative treatments are needed. METHODS: We conducted a randomised, sham-controlled parallel-design, pilot trial. Participants with FC were randomly assigned to either the real acupuncture (RA) or sham acupuncture (SA) group. The RA consisted of eight fixed acupuncture points (bilateral ST25, ST27, BL52 and BL25) and four additional points targeted to the individual based on Traditional Korean medicine (TKM)...
June 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29903008/immunomodulatory-properties-of-quercetin-3-o-%C3%AE-l-rhamnopyranoside-from-rapanea-melanophloeos-against-influenza-a-virus
#13
Parvaneh Mehrbod, Muna Ali Abdalla, Fatemeh Fotouhi, Masoumeh Heidarzadeh, Abimbola O Aro, Jacobus N Eloff, Lyndy J McGaw, Folorunso O Fasina
BACKGROUND: Influenza infection is a major public health threat. The role of influenza A virus-induced inflammatory response in severe cases of this disease is widely recognized. Drug resistance and side effects of chemical treatments have been observed, resulting in increased interest in alternative use of herbal medications for prophylaxis against this infection. The South African medicinal plant, Rapanea melanophloeos (RM) (L.) Mez of the family Myrsinaceae was selected owing to its traditional use for the treatment of several diseases such as respiratory ailments and also previous preliminary studies of anti-influenza activity of its methanolic extract...
June 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29902909/-experience-from-four-dimensions-application-of-classic-formulas-for-treatment-of-dysmenorrhea
#14
Hu You, Chun-Xiang Zhou
The application of classic formulas from Shanghan Zabing Lun has a long history in treatment of dysmenorrhea. However, the understanding on how to use classic formula in treatment of dysmenorrhea is still insufficient in the traditional Chinese medicine (TCM), mainly limited to syndrome differentiation and the formula-syndrome correlation. The treatment method of syndrome differentiation is flexible and changeable, but the process is tedious and difficult to copy. In addition, its experience is not easy to summarize and pass on, and it is difficult for beginners to comprehend the essence...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902907/-external-therapies-of-traditional-chinese-medicine-combined-with-sodium-hyaluronate-injected-in-articular-cavity-therapy-on-knee-osteoarthritis-meta-analysis
#15
Yang-Kai Xu, Fu-Gui Zhu, Er-You Feng, Chao-Ling Fan, Guang-Shu Yu, Yan-Zhen Wei, Li-Hua Xie
To systematically evaluate the efficacy and safety of external therapies of traditional Chinese medicine(TCM) combined with sodium hyaluronate(SH) injected in articular cavity therapy on knee osteoarthritis(KOA). The following databases such as CNKI, WanFang, VIP, CBM, PubMed and Medline were researched to collect the randomized controlled trails on external therapies of TCM combined with sodium hyaluronate injected in articular cavity therapy on KOA. The selection of studies, assessment of methodological quality and data extraction were performed independently by two researchers...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902906/-meta-analysis-of-traditional-chinese-medicine-jianpi-therapy-in-treatment-of-atopic-dermatitis
#16
Yong Liu, Yi-Ding Zhao, Xiao-Ning Yan
To evaluate the clinical efficacy of traditional Chinese medicine Jianpi therapy in the treatment of atopic dermatitis. CNKI, Wanfang knowledge service platform, VIP journal database, Chinese biomedical literature database (CBM), PubMed, the Cochrane Library and EMbase database from inception to December 2017 were searched for the randomized controlled trials (RCTs) on traditional Chinese medicine Jianpi therapy in the treatment of atopic dermatitis. Literature selection and information extraction was completed and screened by two independent reviewers, and then the Cochrane recommended bias risk assessment method was used to evaluate the bias risk, and Review Manager 5...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902903/-mechanisms-of-hirudo-in-promoting-blood-circulation-and-removing-stasis-based-on-network-pharmacology
#17
Luo-Dan Ouyang, Xiao-Song Hu, Ming Niu, Wen Gao, Yu Cheng, Jia-Bo Wang, Li Ma
The study aims to analyze the mechanisms of Hirudo in promoting blood circulation and removing blood stasis based on network pharmacology. A database of chemical components of Hirudo was established through literature retrieval. The targets were predicted by using the reverse pharmacophore matching method and screened according to the antithrombotic and anticoagulant drug targets approved by FDA in the DrugBank database. Then, the targets were analyzed by KEGG pathway analysis, the protein interactions were analyzed by using BioGrid database, and the active constituents-target-pathway network model of Hirudo was established to study the mechanisms of Hirudo in promoting blood circulation and removing blood stasis...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902900/-preliminary-study-on-two-analytical-methods-for-evaluation-of-traditional-chinese-medicine-syndromes-model-in-rats-with-blood-stasis-due-to-sleep-deprivation
#18
Ting-Ting Hao, Hao Guo, Jian-Xun Liu, Jin-Cheng Chen, Jian-Xun Ren, Cheng-Ren Lin, Jun-Guo Ren
The comparison on evaluating blood stasis syndrome in sleep deprived rats was carried out by using R, G, B image analysis of Tongue and palm as well as auricle, palm surface laser Doppler flow perfusion. The experiment was performed by means of a small platform on the water environment for sleep deprivation. The rats were weekly weighed at fixed time, and their macroscopic signs were observed; and their tongue and palm images of the control and model group were respectively collected by the SLR camera at the 2nd, 4th and 6th week...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902880/-chemical-constituents-from-traditional-uighur-herbal-medicine-elaeagnus-angustifolia-flowers
#19
Xiao-Yu Chen, Jian-Xin Han, Yu-Shuang Liu, Aisa Hajiakber, Tao Yuan
Seven aromatic glycosides (1-7), including four phenylethanol glycosides, one phenylmethanol glycoside, one phenylpropane glycoside and one benzoside, were isolated from the methanolic extract of Uighur Medicine Elaeagnus angustifolia flowers. Their structures were elucidated based on the analysis of spectroscopic data (1D, 2D NMR and HR-MS). Compound 1 is a new compound, named as angustifol A. Six known compounds were identified as 2-phenylethyl-O-β-D-glucopyranoside(2), salidroside (3), vanillic acid 4-O-β-D-glucopyranoside(4), vanilloloside (5), (Z)-isoconiferin (6), 2-phenylethyl-6-O-α-L-arabinofuranosyl-β-D-glucopyranoside (7)...
May 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29902864/protective-effect-of-acidic-polysaccharide-from-schisandra-chinensis-on-acute-ethanol-induced-liver-injury-through-reducing-cyp2e1-dependent-oxidative-stress
#20
Rongshuang Yuan, Xue Tao, Shuang Liang, Yan Pan, Li He, Jinghui Sun, Ju Wenbo, Xiangyan Li, Jianguang Chen, Chunmei Wang
AIM: Schisandra chinensis is a well-known traditional Chinese medicine used mainly as a recipe for hepatoprotection. Modern researches have revealed that the hepatoprotection is related to its lignans and crude polysaccharide. In this study, we examined the effect and mechanism of Schisandra chinensis acidic polysaccharide (SCAP) on the liver injury induced by ethanol. MAIN METHODS: SCAP was extracted with water extraction and ethanol precipitation. Liver injury models of both mice and HepG2 cells were produced by ethanol...
March 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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