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https://www.readbyqxmd.com/read/29682706/-risk-factors-of-anastomotic-leakage-in-the-procedures-of-trans-abdominal-and-transanal-total-mesorectal-excision-for-rectal-cancer
#1
Hongwei Yao, Zhongtao Zhang
Anastomotic leakage is one of the most serious complications following traditional trans-abdominal total mesorectal excision of rectal cancer. Anastomotic leakage not only affects the postoperative recovery of patients, but also affects their long-term survival. Transanal total mesorectal excision(taTME) is a new surgical procedure developed in recent years. Its anastomosis is different from traditional trans-abdominal total mesorectal excision surgery. The risk of anastomotic leakage and related risk factors are also different...
2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29682587/therapeutic-potential-of-pien-tze-huang-on-experimental-autoimmune-encephalomyelitis-rat
#2
Xuemei Qiu, Hui Luo, Xue Liu, Qingqing Guo, Kang Zheng, Danping Fan, Jiawen Shen, Cheng Lu, Xiaojuan He, Ge Zhang, Aiping Lu
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). There is still lack of commercially viable treatment currently. Pien Tze Huang (PZH), a traditional Chinese medicine, has been proved to have anti-inflammatory, neuroprotective, and immunoregulatory effects. This study investigated the possible therapeutic effects of PZH on experimental autoimmune encephalomyelitis (EAE) rats, a classic animal model of MS. Male Lewis rats were immunized with myelin basic protein (MBP) peptide to establish an EAE model and then treated with three doses of PZH...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29682561/anti-inflammatory-effect-of-geniposide-on-osteoarthritis-by-suppressing-the-activation-of-p38-mapk-signaling-pathway
#3
Yuan Chen, Kangquan Shou, Chunlong Gong, Huarui Yang, Yi Yang, Tongzhu Bao
It has been suggested that the activation of the p38 mitogen activated protein kinases (MAPKs) signaling pathway plays a significant role in the progression of OA by leading to the overexpression of proinflammatory cytokines, chemokines, and signaling enzymes in human osteoarthritis chondrocytes. However, most p38 MAPK inhibitors applied for OA have been thought to be limited due to their potential long-term toxicities. Geniposide (GE), an iridoid glycoside purified from the fruit of the herb, has been widely used in traditional medicine for the treatment of a variety of chronic inflammatory diseases...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29682150/positive-effect-of-acupuncture-and-cupping-in-infertility-treatment
#4
Jun-Xiang Wang, Yang Yang, Yue Song, Liang-Xiao Ma
Background: Infertility is clinically defined as the failure to conceive after 12 months of unprotected sexual intercourse. Organic disorders and lifestyle factors are highly associated with infertility. Generally, acupuncture and its related methods can be applied for treating infertility, according to the theory of Traditional Chinese Medicine. Successful cases of acupuncture-treated infertility without concomitant use of any medication are rare. This article presents a case of an infertile woman having a favorable response to acupuncture treatment...
April 1, 2018: Medical Acupuncture
https://www.readbyqxmd.com/read/29682147/acupuncture-or-acupressure-on-yintang-ex-hn-3-for-anxiety-a-preliminary-review
#5
REVIEW
Chan-Young Kwon, Boram Lee
Background: Anxiety is a very common psychiatric symptom and can also occur in many physical conditions. Due to the limitations of conventional pharmacotherapy, the discovery of nonpharmacologic treatments that alleviate anxiety effectively is clinically important. Yintang (EX-HN 3), an acupoint located between the eyebrows, is known to have a mentally stabilizing effect in Traditional Chinese Medicine. Objectives: This preliminary review was conducted to investigate the current state of studies using acupressure or acupuncture on EX-HN 3 alone for anxiety, and to explore ways to apply this in clinical settings and future research, including systematic reviews and clinical trials...
April 1, 2018: Medical Acupuncture
https://www.readbyqxmd.com/read/29681983/time-sex-and-dose-dependent-alterations-of-the-gut-microbiota-by-consumption-of-dietary-daikenchuto-tu-100
#6
Jun Miyoshi, Kentaro Nobutani, Mark W Musch, Daina L Ringus, Nathaniel A Hubert, Masahiro Yamamoto, Yoshio Kase, Mitsue Nishiyama, Eugene B Chang
Medications or dietary components can affect both the host and the host's gut microbiota. Changes in the microbiota may influence medication efficacy and interactions. Daikenchuto (TU-100), a herbal medication, comprised of ginger, ginseng, and Japanese pepper, is widely used in Japanese traditional Kampo medicine for intestinal motility and postoperative paralytic ileus. We previously showed in mice that consumption of TU-100 for 4 weeks changed the gut microbiota and increased bioavailability of bacterial ginsenoside metabolites...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681980/anti-helicobacter-pylori-and-anti-inflammatory-effects-and-constituent-analysis-of-modified-xiaochaihutang-for-the-treatment-of-chronic-gastritis-and-gastric-ulcer
#7
Xin Chen, Lijuan Hu, Huanhuan Wu, Wei Liu, Shuhe Chen, Aijun Zhou, Yanwen Liu
Chronic gastritis and gastric ulcers are prevalent throughout the world and are considered to be a global health problem. Modified Xiaochaihutang (MXCHT) prescription is broadly used in traditional medicine hospital for the treatment of gastritis. In order to assess the anti- Helicobacter pylori (H. pylori) effect of MXCHT, agar diffusion method in vitro and fluid dilution method for the minimal inhibitory concentration (MIC) were established. The anti-inflammatory effects were then evaluated using mouse ear edema model and rat paw edema model...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681972/-in-vitro-bioactivity-of-methanolic-extracts-from-amphipterygium-adstringens-schltdl-schiede-ex-standl-chenopodium-ambrosioides-l-cirsium-mexicanum-dc-eryngium-carlinae-f-delaroche-and-pithecellobium-dulce-roxb-benth-used-in-traditional-medicine-in-mexico
#8
Peter Knauth, Gustavo J Acevedo-Hernández, M Eduardo Cano, Melesio Gutiérrez-Lomelí, Zaira López
Seven out of eight methanolic extracts from five plants native to Mexico were inactive against ten bacterial strains of clinical interest. The fruit extract of Chenopodium ambrosioides inhibited the bacteria Enterococcus faecalis (MIC = 4375  μ g/ml), Escherichia coli (MIC = 1094  μ g/ml), and Salmonella typhimurium (MIC = 137  μ g/ml). The fruit extract of C. ambrosioides was with CC50 = 45  μ g/ml most cytotoxic against the cell-line Caco-2, followed by the leaf extract from Pithecellobium dulce (CC50 = 126  μ g/ml); interestingly, leaves of C...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681970/-k-nearest-neighbor-algorithm-coupled-with-metabonomics-to-study-the-therapeutic-mechanism-of-sendeng-4-in-adjuvant-induced-rheumatoid-arthritis-rat
#9
Xiye Wang, Dan Li, Mingyang Jiang, Zhili Pei, Liang Xu
As a traditional Mongolian medicine, Sendeng-4 (SD) has been widely used to treat rheumatoid arthritis (RA) in Inner Mongolia and exhibits a good curative effect. Unfortunately, due to geographical factors, it is difficult to popularize this drug throughout the whole country, and the mechanism of action of SD has been unclear. In this study, a serum metabolite profile analysis was performed to identify potential biomarkers associated with adjuvant-induced RA and investigate the mechanism of action of SD. Ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) was performed for the metabonomics analysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681854/evidence-supports-tradition-the-in-vitro-effects-of-roman-chamomile-on-smooth-muscles
#10
Zsolt Sándor, Javad Mottaghipisheh, Katalin Veres, Judit Hohmann, Tímea Bencsik, Attila Horváth, Dezső Kelemen, Róbert Papp, Loránd Barthó, Dezső Csupor
The dried flowers of Chamaemelum nobile (L.) All. have been used in traditional medicine for different conditions related to the spasm of the gastrointestinal system. However, there have been no experimental studies to support the smooth muscle relaxant effect of this plant. The aim of our research was to assess the effects of the hydroethanolic extract of Roman chamomile, its fractions, four of its flavonoids (apigenin, luteolin, hispidulin, and eupafolin), and its essential oil on smooth muscles. The phytochemical compositions of the extract and its fractions were characterized and quantified by HPLC-DAD, the essential oil was characterized by GC and GC-MS...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681848/development-of-an-ultrasonication-assisted-extraction-based-hplc-with-a-fluorescence-method-for-sensitive-determination-of-aflatoxins-in-highly-acidic-hibiscus-sabdariffa
#11
Xiaofei Liu, Guangyao Ying, Chaonan Sun, Meihua Yang, Lei Zhang, Shanshan Zhang, Xiaoyan Xing, Qian Li, Weijun Kong
The high acidity and complex components of Hibiscus sabdariffa have provided major challenges for sensitive determination of trace aflatoxins. In this study, sample pretreatment of H. sabdariffa was systematically developed for sensitive high performance liquid chromatography-fluorescence detection (HPLC-FLD) after ultrasonication-assisted extraction, immunoaffinity column (IAC) clean-up and on-line post-column photochemical derivatization (PCD). Aflatoxins B1 , B2 , G1 , G2 were extracted from samples by using methanol/water (70:30, v/v ) with the addition of NaCl...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681184/tam-infiltration-differences-in-tumor-first-and-zheng-first-models-and-the-underlying-inflammatory-molecular-mechanism-in-pancreatic-cancer
#12
Feng-Jiao Wang, Peng Wang, Lian-Yu Chen, Ya-Wen Geng, Hao Chen, Zhi-Qiang Meng, Lu-Ming Liu, Zhen Chen
BACKGROUND: Syndrome ( ZHENG in Chinese) in traditional Chinese medicine (TCM) refers to the intrinsic characteristics of a pathological process at a certain stage; these characteristics are influenced by internal and external environments and reveal the nature of a disease. Proper syndrome differentiation is the basic principle that guides clinical treatment. OBJECTIVE: To have a good understanding of tumor progression and the different mechanisms related to ZHENG that have occurred before and after tumor development and to explore the valid evaluation criteria of different pancreatic cancer syndromes to improve the guiding role of TCM syndrome differentiation in pancreatic cancer treatment...
April 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29680703/evaluation-of-phase-separation-in-a-single-stage-vertical-anaerobic-reactor-performance-and-microbial-composition-analysis
#13
Longyi Lv, Weiguang Li, Jiyong Bian, Yang Yu, Donghui Li, Zejia Zheng
In order to explore whether the acidogenic phase and methanogenic phase could be separated vertically into a single-stage anaerobic reactor, a controlled double circulation (CDC) anaerobic reactor was proposed for treating traditional Chinese medicine (TCM) wastewater in this study. The results showed that most of the organic pollutants and refractory were removed in the first reaction area where most of the amount of sludge existed. The organic acids were accumulated in the first reaction area, and larger specific methanogenic activity (SMA) and coenzyme F420 values were found in the second reaction area...
April 11, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29680098/modeling-clinical-outcomes-in-prostate-cancer-application-and-validation-of-the-discrete-event-simulation-approach
#14
Feng Pan, Odette Reifsnider, Ying Zheng, Irina Proskorovsky, Tracy Li, Jianming He, Sonja V Sorensen
OBJECTIVES: Treatment landscape in prostate cancer has changed dramatically with the emergence of new medicines in the past few years. The traditional survival partition model (SPM) cannot accurately predict long-term clinical outcomes because it is limited by its ability to capture the key consequences associated with this changing treatment paradigm. The objective of this study was to introduce and validate a discrete-event simulation (DES) model for prostate cancer. METHODS: A DES model was developed to simulate overall survival (OS) and other clinical outcomes based on patient characteristics, treatment received, and disease progression history...
April 2018: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/29679721/effectiveness-evaluation-of-digital-virtual-simulation-application-in-teaching-of-gross-anatomy
#15
Xiaohua Deng, Guowei Zhou, Bing Xiao, Zirui Zhao, Yicheng He, Chujun Chen
INTRODUCTION: digital virtual simulation (DVS) is increasingly used to supplement the teaching of anatomy. DVS can provide the students with three-dimensional (3D) stereoscopic images and precise structures in anatomy teaching. We investigated the effects of digital virtual simulation (DVS) application in gross anatomy teaching. MATERIALS AND METHODS: fourth-year medical students (n=120), majoring clinical medicine in 2013 grade from Xiangya School of Medicine, Central South University, were assigned into four classes...
April 18, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29679640/cepfostering-efficacy-and-toxicity-evaluation-of-traditional-chinese-medicine-and-natural-products
#16
REVIEW
Tong Wu, Gui-Yuan Yu, Jia Xiao, Chang Yan, Hiroshi Kurihara, Yi-Fang Li, Kwok-Fai So, Rong-Rong He
Efficacy and safety assessments are essential thresholds for drug candidates from preclinical to clinical research. Conventional mammalian in vivo models cannot offer rapid pharmacological and toxicological screening, whereas cell-based or cell-free in vitro systems often lead to inaccurate results because of the lack of physiological environment. Within the avian species, chick is the first bird to have its genome sequencing. Meantime, chick embryo is an easily operating, relatively transparent and extensively accessible model, whose physiological and pathological alterations can be visualized by egg candler, staining and image technologies...
April 18, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29679266/changes-in-content-of-triterpenoids-and-polysaccharides-in-ganoderma-lingzhi-at-different-growth-stages
#17
Toshinori Nakagawa, Qinchang Zhu, Sonam Tamrakar, Yhiya Amen, Yasuhiro Mori, Hiroto Suhara, Shuhei Kaneko, Hiroko Kawashima, Kotaro Okuzono, Yoshiyuki Inoue, Koichiro Ohnuki, Kuniyoshi Shimizu
Ganoderma lingzhi is a traditional medicinal mushroom, and its extract contains many bioactive compounds. Triterpenoids and polysaccharides are the primary bioactive components that contribute to its medicinal properties. In this study, we quantified 18 triterpenoids, total triterpenoid content and total polysaccharide content in the ethanol and water extracts of G. lingzhi at different growth stages. Triterpenoids were quantified by liquid chromatograph-tandem mass spectrometry in the multiple-reaction-monitoring mode...
April 20, 2018: Journal of Natural Medicines
https://www.readbyqxmd.com/read/29679255/needle-tissue-interactive-mechanism-and-steering-control-in-image-guided-robot-assisted-minimally-invasive-surgery-a-review
#18
Pan Li, Zhiyong Yang, Shan Jiang
Image-guided robot-assisted minimally invasive surgery is an important medicine procedure used for biopsy or local target therapy. In order to reach the target region not accessible using traditional techniques, long and thin flexible needles are inserted into the soft tissue which has large deformation and nonlinear characteristics. However, the detection results and therapeutic effect are directly influenced by the targeting accuracy of needle steering. For this reason, the needle-tissue interactive mechanism, path planning, and steering control are investigated in this review by searching literatures in the last 10 years, which results in a comprehensive overview of the existing techniques with the main accomplishments, limitations, and recommendations...
April 21, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29678043/an-automated-technique-to-construct-a-knowledge-base-of-traditional-chinese-herbal-medicine-for-cancers-an-exploratory-study-for-breast-cancer
#19
Phung Anh Nguyen, Hsuan-Chia Yang, Rong Xu, Yu-Chuan Jack Li
Traditional Chinese Medicine utilization has rapidly increased worldwide. However, there is limited database provides the information of TCM herbs and diseases. The study aims to identify and evaluate the meaningful associations between TCM herbs and breast cancer by using the association rule mining (ARM) techniques. We employed the ARM techniques for 19.9 million TCM prescriptions by using Taiwan National Health Insurance claim database from 1999 to 2013. 364 TCM herbs-breast cancer associations were derived from those prescriptions and were then filtered by their support of 20...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677121/prophylactic-neuroprotection-of-total-glucosides-of-paeoniae-radix-alba-against-semen-strychni-induced-neurotoxicity-in-rats-suppressing-oxidative-stress-and-reducing-the-absorption-of-toxic-components
#20
Shujuan Li, Yanjie Chu, Ruowen Zhang, Linjia Sun, Xiaohui Chen
Strychnos alkaloids (SAs) are the main toxic constituents in Semen Strychni, a traditional Chinese medicine, which is known for its fatal neurotoxicity. Hence, the present study was carried out to evaluate the neurotoxicity induced by SAs and the pre-protective effects of the total glucosides of Paeoniae Radix Alba (TGP). An SA brain damage model was firstly established. The neurotoxicity induced by SAs and the pre-protective effects of TGP were confirmed by physical and behavioral testing, biochemical assay, and histological examination...
April 20, 2018: Nutrients
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