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https://www.readbyqxmd.com/read/27908574/reconstruction-of-a-post-traumatic-maxillary-ridge-using-a-radial-forearm-free-flap-and-immediate-tissue-engineering-bone-morphogenetic-protein-bone-marrow-aspirate-concentrate-and-cortical-cancellous-bone-case-report
#1
James C Melville, Ramzey Tursun, J Marshall Green, Robert E Marx
The purpose of this article is to describe reconstruction of the maxillary alveolar ridge by use of a microvascular free flap combined with an immediate tissue-engineered bone graft. This novel surgical technique involved the use of a radial forearm free flap and immediate allogeneic avascular bone graft augmented with bone morphogenetic protein and bone marrow aspirate concentrate. A poly-d,l-lactic acid mesh was used a containment unit for the bone graft. The patient was successfully treated with a viable radial forearm free flap for soft tissue and regeneration of bone with adequate height and width, which allowed the placement of 3 dental implants with excellent arch coordination...
November 9, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27880906/emergence-of-a-wave-of-wnt-signaling-that-regulates-lung-alveologenesis-by-controlling-epithelial-self-renewal-and-differentiation
#2
David B Frank, Tien Peng, Jarod A Zepp, Melinda Snitow, Tiffaney L Vincent, Ian J Penkala, Zheng Cui, Michael J Herriges, Michael P Morley, Su Zhou, Min Min Lu, Edward E Morrisey
Alveologenesis is the culmination of lung development and involves the correct temporal and spatial signals to generate the delicate gas exchange interface required for respiration. Using a Wnt-signaling reporter system, we demonstrate the emergence of a Wnt-responsive alveolar epithelial cell sublineage, which arises during alveologenesis, called the axin2+ alveolar type 2 cell, or AT2(Axin2). The number of AT2(Axin2) cells increases substantially during late lung development, correlating with a wave of Wnt signaling during alveologenesis...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27870344/elastic-properties-of-chimpanzee-craniofacial-cortical-bone
#3
Poorva Gharpure, Elias D Kontogiorgos, Lynne A Opperman, Callum F Ross, David S Strait, Amanda Smith, Leslie C Pryor, Qian Wang, Paul C Dechow
Relatively few assessments of cranial biomechanics formally take into account variation in the material properties of cranial cortical bone. Our aim was to characterize the elastic properties of chimpanzee craniofacial cortical bone and compare these to the elastic properties of dentate human craniofacial cortical bone. From seven cranial regions, 27 cylindrical samples were harvested from each of five chimpanzee crania. Assuming orthotropy, axes of maximum stiffness in the plane of the cortical plate were derived using modified equations of Hooke's law in a Mathcad program...
December 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/27849354/the-treatment-effects-of-flaxseed-derived-secoisolariciresinol-diglycoside-and-its-metabolite-enterolactone-on-benign-prostatic-hyperplasia-involve-the-g-protein-coupled-estrogen-receptor-1
#4
Guan-Yu Ren, Chun-Yang Chen, Wei-Guo Chen, Ya Huang, Li-Qiang Qin, Li-Hua Chen
Secoisolariciresinol diglucoside (SDG), a lignan extracted from flaxseed, has been shown to suppress benign prostatic hyperplasia (BPH). However, little is known about the mechanistic basis for its anti-BPH activity. The present study showed that enterolactone (ENL), the mammalian metabolite of SDG, shared the similar binding site of G1 on a new type of membranous estrogen receptor, G-protein-coupled estrogen eceptor 1 (GPER), by docking simulations method. ENL and G1 (the specific agonist of GPER) inhibited the proliferation of human prostate stromal cell line WPMY-1 as shown by MTT assay and arrested cell cycle at the G0/G1 phase, which was displayed by propidium iodide staining following flow cytometer examination...
December 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/27849104/biomechanical-comparison-of-two-ostectomy-configurations-for-partial-mandibulectomy
#5
Daniel Linden, Brad M Matz, Ramsis Farag, Harry W Boothe, D Michael Tillson, Ralph Henderson
OBJECTIVE: To determine the stiffness and load to failure of two different ostectomy configurations using canine mandibles. STUDY DESIGN: Cadaveric biomechanical assessment. ANIMALS: Paired mandibles (n = 30). METHODS: Standardized partial ostectomies were created on the alveolar surface of 30 mandibles. Samples were randomly assigned to right-angled (n = 15) or crescentic ostectomy (n = 15). Excision spanned the mesial aspect of the fourth premolar tooth to the distal aspect of first molar tooth...
November 16, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27834817/classification-of-27-tumor-associated-antigens-by-histochemical-analysis-of-36-freshly-resected-lung-cancer-tissues
#6
Gene Kurosawa, Mototaka Sugiura, Yoshinobu Hattori, Hiroyuki Tsuda, Yoshikazu Kurosawa
In previous studies, we identified 29 tumor-associated antigens (TAAs) and isolated 488 human monoclonal antibodies (mAbs) that specifically bind to one of the 29 TAAs. In the present study, we performed histochemical analysis of 36 freshly resected lung cancer tissues by using 60 mAbs against 27 TAAs. Comparison of the staining patterns of tumor cells, bronchial epithelial cells, and normal pulmonary alveolus cells and interalveolar septum allowed us to determine the type and location of cells that express target molecules, as well as the degree of expression...
November 8, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27802588/gene-profiles-in-a-smoke-induced-copd-mouse-lung-model-following-treatment-with-mesenchymal-stem-cells
#7
You-Sun Kim, Nurdan Kokturk, Ji-Young Kim, Sei Won Lee, Jaeyun Lim, Soo Jin Choi, Wonil Oh, Yeon-Mok Oh
Mesenchymal stem cells (MSCs) effectively reduce airway inflammation and regenerate the alveolus in cigarette- and elastase-induced chronic obstructive pulmonary disease (COPD) animal models. The effects of stem cells are thought to be paracrine and immune-modulatory because very few stem cells remain in the lung one day after their systemic injection, which has been demonstrated previously. In this report, we analyzed the gene expression profiles to compare mouse lungs with chronic exposure to cigarette smoke with non-exposed lungs...
October 2016: Molecules and Cells
https://www.readbyqxmd.com/read/27792826/cervical-metastasis-in-squamous-cell-carcinoma-of-the-hard-palate-and-maxillary-alveolus
#8
Yekaterina Koshkareva, Jeffrey C Liu, Miriam Lango, Thomas Galloway, John P Gaughan, John A Ridge
We conducted a retrospective study to determine the incidence and treatment outcomes of neck metastases in patients with squamous cell carcinoma (SCC) of the hard palate and/or maxillary alveolus after surgical excision of the primary tumor. We also sought to identify any risk factors for recurrence. Our study population was made up of 20 patients-9 men and 11 women, aged 46 to 88 years (mean: 72.6)-who had undergone excision of an SCC of the hard palate and/or maxillary alveolus at a tertiary care cancer center over a 7-year period...
October 2016: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/27771163/influence-of-secondary-wound-healing-after-mandibular-third-molar-coronectomy
#9
S Franco, E Vignudelli, G Monaco, C Marchetti
Our aim was to describe the postoperative morbidity related to secondary wound healing after coronectomy. Ten of 116 patients treated by coronectomy healed by second intention as a result of failed sutures. We made a retrospective analysis after two years to evaluate the postoperative morbidity related to secondary wound healing. The complete closure of the alveolus of the 10 surgical sites was recorded three months after coronectomy. No patients had postoperative infections, dry socket, or pulpitis. All patients were free of symptoms, the retained roots were completely included, and were not detectable with a periodontal probe...
October 19, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27767023/radiographic-study-of-the-prevalence-and-distribution-of-hypodontia-associated-with-unilateral-and-bilateral-clef-lip-and-palate-in-a-hungarian-population
#10
Ádám Berniczei-Roykó, Jan-Hendrik Tappe, Axel Krinner, Tomasz Gredes, András Végh, Katona Gábor, Kamila Linkowska-Świdzińska, Ute Ulrike Botzenhart
BACKGROUND Cleft defects are one of the most frequent birth-deformities of the orofacial region and they are commonly associated with anomalies of the tooth structure, size, shape, formation, eruption, and tooth number. The aim of our study was to evaluate the prevalence, distribution, and potential association of combined hypodontia in cleft-affected patients with regard to all types of teeth in both jaws in the permanent dentition. MATERIAL AND METHODS This retrospective radiographic analysis included patients with various types of clefts treated orthodontically in the Department of Orofacial Orthopedics and Orthodontics at Heim Pàl Children's Hospital, Budapest...
October 21, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27764909/value-of-sagittal-color-doppler-ultrasonography-as-a-supplementary-tool-in-the-differential-diagnosis-of-fetal-cleft-lip-and-palate
#11
Myoung Seok Lee, Jeong Yeon Cho, Sang Youn Kim, Seung Hyup Kim, Joong Shin Park, Jong Kwan Jun
Purpose: The purpose of this study was to evaluate the feasibility and usefulness of sagittal color Doppler ultrasonography (CDUS) for the diagnosis of fetal cleft lip (CL) and cleft palate (CP). Methods: We performed targeted ultrasonography on 25 fetuses with CL and CP, taking coronal and axial images of the upper lip and maxillary alveolar arch in each case. The existence of defects in and malalignment of the alveolus on the axial image, hard palate defects on the midsagittal image, and flow-through defects on CDUS taken during fetal breathing or swallowing were assessed...
August 6, 2016: Ultrasonography
https://www.readbyqxmd.com/read/27746008/delayed-onset-infections-after-lower-third-molar-germectomy-could-be-related-to-the-space-distal-to-the-second-molar
#12
G Monaco, S Cecchini, M R Gatto, G A Pelliccioni
The onset of delayed infection after lower third molar germectomy is influenced by the amount of distal space. This retrospective study aimed to determine whether the incidence of delayed onset infection is related to the space distal to the second molar. The ratio between the distal space and the crown width, measured according to the Ganss protocol on panoramic radiographs, was obtained for 218 surgical germectomies performed for orthodontic reasons in 134 patients. A delayed onset infection occurred following 20 germectomies at between 2 and 8 weeks after surgery; purulent exudates from the alveolus and swelling were present...
October 13, 2016: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27745784/preoperative-evaluation-of-micro-organisms-in-non-operated-cleft-in-soft-palate-impact-on-use-of-antibiotics
#13
G J Roode, K-W Bütow, S Naidoo
To identify the pathogenic micro-organisms that had colonised preoperatively in clefts in the soft palate and oro-nasopharynx, we retrospectively studied the preoperative microbiological profiles of 200 infants who had had primary repair of all types of cleft in the soft palate. Data from a private practice that specialises in the repair of facial clefts were extracted randomly from patients' files. We analysed the results of the culture of preoperative swabs taken from clefts in the soft palate and oro-nasopharynx, and the resistance profile of organisms towards various antibiotics...
October 10, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27721622/embryonal-rhabdomyosarcoma-a-rare-oral-tumor
#14
Sila Datta, Jay Gopal Ray, Tushar Deb, Santanu Patsa
Rhabdomyosarcoma is the malignant neoplasm of striated muscle and a relatively uncommon tumor of the oral cavity. Embryonal variety is the most common subtype, observed in children below 10 years of age but occasionally seen in adolescents and young adults. The present report describes a case of embryonal rhabdomyosarcoma in the left posterior buccal mucosa, with extension in the adjacent alveolus, soft palate, oropharynx and nasopharynx of a 17-year-old female.
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27667546/long-term-outcomes-of-simplified-gingivoperiosteoplasty-performed-at-the-time-of-hard-palatal-closure-a-review-of-55-alveolar-clefts
#15
Kihwan Han, Jungheum Park, Jaehoon Choi, Daegu Son
Few studies have examined the long-term outcomes of gingivoperiosteoplasty at the age of permanent canine eruption. The success rates of gingivoperiosteoplasty vary significantly depending on the surgeon because of the difficulty of the surgical technique. Therefore, the authors utilized a simplified gingivoperiosteoplasty technique by inserting one or two large, triangular-shaped mucoperiosteal flaps on the opposite side in a tongue-in-groove or interdigitation fashion. The purpose of this study was to evaluate the long-term outcomes of this simplified gingivoperiosteoplasty technique at the age of permanent canine eruption...
September 7, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27638039/long-term-mid-facial-growth-of-patients-with-a-unilateral-complete-cleft-of-lip-alveolus-and-palate-treated-by-two-stage-palatoplasty-cephalometric-analysis
#16
I F P M Kappen, G K P Bittermann, R M Schouten, D Bittermann, E Etty, R Koole, M Kon, A B Mink van der Molen, C C Breugem
OBJECTIVES: The aim of this study is to evaluate long-term facial growth in adults previously treated for an isolated unilateral complete cleft lip, alveolus and palate by two-stage palatoplasty. MATERIALS AND METHODS: Unilateral cleft lip and palate (UCLP) patients of 17 years and older treated by two-stage palatoplasty were invited for long-term follow-up. During follow-up, lateral cephalograms were obtained (n = 52). Medical history was acquired from their medical files...
September 16, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27633512/replantation-of-a-displaced-incisor-in-a-boy-with-a-cleft-lip-and-alveolus-a-case-report
#17
Heidrun Schaaf, Heiko Kerkmann, Felix Pitka, Niko Christian Bock, Sameh Attia
BACKGROUND: Tooth replantation after traumatic avulsion or transplantation is a challenge in oral surgery. A special method named auto-alloplastic replantation, in which a titanium post is used after extraoral endodontic treatment, combines several advantages. The treatment is performed in one step with no further endodontic intervention, no wide root canal instrumentation, no recontamination, and reduced endodontic infection. This is the first report on replantation of an ectopic tooth in a patient with a cleft lip and alveolus using this method...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27548400/use-of-a-resin-bonded-bridge-to-replace-a-congenitally-missing-lateral-incisor-treatment-of-intrusion-of-teeth
#18
Paul S Rosen, Oded Bahat, Stuart J Froum, Fereidoun Daftary, Howard Rosenthal, Sylvan Feldman
Craniofacial growth is an important factor to consider when providing dental implant treatment for adolescents to replace missing teeth. Ongoing longitudinal observation has demonstrated that such tooth replacements may appear intruded over time, because there may be ongoing downward and anterior movement of both the alveolus and the teeth at a rate exceeding that of the dental implant, which acts like an ankylosed unit. This case reports on a 23.5-year-old female patient who, at age 16, had orthodontics completed and was left with a space where the maxillary right lateral incisor was congenitally missing with the hope of future restoration with a dental implant...
July 2016: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27537228/nasal-airway-dysfunction-in-children-with-cleft-lip-palate-results-of-a-cross-sectional-population-based-study-with-anatomic-and-surgical-considerations
#19
Danielle L Sobol, Alexander C Allori, Anna R Carlson, Irene J Pien, Stephanie E Watkins, Arthur S Aylsworth, Robert E Meyer, Luiz A Pimenta, Ronald P Strauss, Barry L Ramsey, Eileen Raynor, Jeffrey R Marcus
BACKGROUND: The aesthetic aspects of the cleft lip nasal deformity have been appreciated for over a century, but the functional implications of the deformity have remained largely misunderstood or underappreciated. This study aims to describe the frequency and severity of nasal obstructive symptoms among children and adolescents with cleft lip and/or palate (CL/P), addressing the hypotheses that age and cleft type/severity are associated with the development of nasal obstructive symptoms...
August 15, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27519658/surgical-reconstruction-of-maxillary-defects-using-a-computer-assisted-design-computer-assisted-manufacturing-produced-titanium-mesh-supporting-a-free-flap
#20
Achille Tarsitano, Salvatore Battaglia, Leonardo Ciocca, Roberto Scotti, Riccardo Cipriani, Claudio Marchetti
The maxilla provides support to the overlying structures and contributes significantly to the overall facial appearance and to critical functions such as mastication, speech, and deglutition. Many different techniques have been used over the years to achieve this reconstructive goal. Modern computer-assisted surgery affords new methods for planning resections, as well as optimising reconstructive outcomes and functional rehabilitation. The aim of this study was to describe our experience with, and technique for, the functional, structural, and aesthetic reconstruction of maxillary bone defects using a computer-assisted design (CAD)/computer-assisted manufacturing (CAM)-printed titanium mesh to provide structural support for free flap reconstruction...
September 2016: Journal of Cranio-maxillo-facial Surgery
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