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https://www.readbyqxmd.com/read/29447055/advanced-microengineered-lung-models-for-translational-drug-discovery
#1
Brian F Niemeyer, Peng Zhao, Rubin M Tuder, Kambez H Benam
Lung diseases impose a significant socioeconomic burden and are a leading cause of morbidity and mortality worldwide. Moreover, respiratory medicine, unlike several other therapeutic areas, faces a disappointingly low number of new approved therapies. This is partly due to lack of reliable in vitro or in vivo models that can reproduce organ-level complexity and pathophysiological responses of human lung. Here, we examine new opportunities in application of recently emerged organ-on-chip technology to model human lung alveolus and small airway in preclinical drug development and biomarker discovery...
February 1, 2018: SLAS Discovery
https://www.readbyqxmd.com/read/29399755/using-3d-digital-models-to-establish-alveolar-morphotype
#2
Maja Konvalinkova, Wanda Urbanova, Katerina Langova, Magdalena Kotova
BACKGROUND AND AIMS: To propose a classification of alveolar morphotype, and assess a relationship between extraction/non-extraction orthodontic treatment and changes to the alveolar process. METHODS: Seventy-five subjects (mean age = 23.2, SD = 5.1) were selected. Areas of the sections of the alveolar process (ASAP) at three different levels (0, 2, and 4 mm) were measured on pre- and post-treatment 3D digital models. Method reliability was analyzed using Dahlberg's formula, intraclass correlation coefficient (ICC), and paired t-tests...
February 5, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29384701/evaluation-of-alveolar-bone-support-around-incisors-in-patients-with-unilateral-cleft-lip-alveolus-and-palate-in-late-mixed-dentition-using-cone-beam-computed-tomography
#3
Yingdan Pan, Yunting Zeng, Zeyu Zhang, Yiqin Liu, Yi Jing, Liwei Xiao
OBJECTIVES: To evaluate alveolar bone support around cleft-adjacent maxillary central incisors (U1) in patients with unilateral cleft lip, alveolus and palate (UCLAP) in the late mixed dentition and to investigate the correlation between the alveolar bone thickness (ABT) and tooth inclination. MATERIALS AND METHODS: Cone beam computed tomography scans of 45 subjects with UCLAP (29 boys, 16 girls; mean age = 10.74 ± 1.08 years) were assessed. The distance between the cementoenamel junction (CEJ) and alveolar bone crest (AC), and the ABTs at 3 mm, 6 mm, and the apex were measured on the labial, lingual and distal surfaces of U1...
January 31, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29374248/role-of-quzhou-fructus-aurantii-extract-in-preventing-and-treating-acute-lung-injury-and-inflammation
#4
Lili Li, Sheng Zhang, Yanfei Xin, Junying Sun, Feng Xie, Lin Yang, Zhiqin Chen, Hao Chen, Fang Liu, Yaoxian Xuan, Zhenqiang You
Quzhou Fructus Aurantii (QFA) is an authentic herb of local varieties in Zhejiang, China, which is usually used to treat gastrointestinal illnesses, but its effects on respiratory inflammation have not been reported yet. In our study, the anti-inflammatory activity of QFA extract (QFAE) was evaluated on copper sulfate pentahydrate (CuSO4·5H2O)-induced transgenic neutrophil fluorescent zebrafish model. QFAE showed a significant effect of anti-inflammation in CuSO4·5H2O-induced zebrafish by reducing the neutrophil number in the inflammatory site...
January 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29356619/the-effect-of-nasoalveolar-molding-on-nasal-airway-anatomy-a-9-year-follow-up-of-patients-with-unilateral-cleft-lip-and-palate
#5
Jonathan P Massie, Karl Bruckman, William J Rifkin, Christopher M Runyan, Pradip R Shetye, Barry Grayson, Roberto L Flores
OBJECTIVE: To determine the effects of nasoalveolar molding (NAM) on nasal airway architecture. DESIGN: Retrospective case-control study of patients with unilateral cleft lip treated with NAM vs without NAM. SETTING: Tertiary referral center specializing in cleft and craniofacial care. Patients, Participants, and Interventions: Thirty-six patients with complete unilateral cleft lip and alveolus: 19 with NAM therapy and 17 without NAM therapy...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29321014/current-status-of-nylon-teeth-myth-in-tanzania-a-cross-sectional-study
#6
Emeria Abella Mugonzibwa, Febronia Kokulengya Kahabuka, Samwel Charles Mwalutambi, Emil Namakuka Kikwilu
BACKGROUND: Nylon teeth myth is a belief of associating infant illnesses with bulges on infants' alveolus that mark the positions of underlying developing teeth and that it is necessary to treat the condition mainly by traditional healers to prevent infant death. The traditional treatment often leads to serious complications that may lead to infant death. Although the government instituted educational campaigns against the myth in 1980s to 1990s, to date, repeated unpublished reports from different parts of the country indicate continued existence of the myth...
January 10, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29285334/bisphosphonates-therapy-in-children-with-osteogenesis-imperfecta-clinical-experience-in-oral-surgery
#7
G Ierardo, M Bossù, G D'Angeli, M Celli, G Sfasciotti
Objectives: To define the possible complications of oral surgery in childhood in patients affected by type 1 Osteogenesis imperfecta (OI) and treated with bisphosphonates (BP). Methods: The study was conducted among 20 patients in childhood with an age range 8-14 (12 ♂ e 8 ♀) affected by OI. Patients were initially evaluated at the Policlinico Umberto I, University Hospital of Rome, Rare Disease Center Skeletal Dysplasia-Bone Metabolic Pathologies and after at the Policlinico Umberto I, University Hospital of Rome, Head and Neck Department, UOC Pediatric Dentistry...
July 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29284981/neurilemmoma-of-maxillary-alveolus-a-rare-case-report-and-review-of-literature
#8
Saravanan Kandasamy, R Senthil Nathan, Reena Rachel John
Schwannomas or neurilemmomas are benign, slow growing, usually solitary and encapsulated tumor, originating from Schwann cells of the nerve sheath. Intraoral schwannomas account for 1% of head and neck region and are commonly seen at the base of the tongue. Most of the literature, reports of schwannomas in the tongue region are common. In this article we report a rare occurrence of schwannoma in the maxillary alveolus region and its management. A 45 year old female patient reported to the department of oral and maxillofacial surgery with a complaint of swelling in the left maxillary alveolus in relation to molar teeth that had been present for more than 3 months...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29249870/effects-of-fty720-on-lung-injury-induced-by-hindlimb-ischemia-reperfusion-in-rats
#9
Liangrong Wang, Feifei Chen, Yafei Pan, Lina Lin, Xiangqing Xiong
Background: Sphingosine-1-phosphate (S1P) is a biologically active lysophospholipid mediator involved in modulating inflammatory process. We investigated the effects of FTY720, a structural analogue of S1P after phosphorylation, on lung injury induced by hindlimb ischemia reperfusion (IR) in rats. Methods: Fifty Sprague-Dawley rats were divided into groups SM, IR, F3, F5, and F10. Group SM received sham operation, and bilateral hindlimb IR was established in group IR...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29225322/immunohistochemical-study-on-the-secretory-host-defense-system-with-lysozyme-and-secretory-phospholipase-a2-throughout-rat-respiratory-tract
#10
Natsumi Masuda, Youhei Mantani, Chiaki Yoshitomi, Hideto Yuasa, Miho Nishida, Masaya Arai, Junichi Kawano, Toshifumi Yokoyama, Nobuhiko Hoshi, Hiroshi Kitagawa
The host defense system with lysozyme and secretory phospholipase A2 (sPLA2) was immunohistochemically investigated in rat respiratory tract under healthy conditions. In the nasal epithelium, a large number of non-ciliated and non-microvillous cells (NC) and a small number of goblet cells (GC) were immunopositive for lysozyme and sPLA2. A few acinar cells and almost all epithelial cells of intercalated ducts were immunopositive for both bactericidal substances in the nasal glands. In the laryngeal and tracheal epithelia, few NC and GC were immunopositive for both bactericidal substances...
December 8, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29223639/extensive-phenotyping-of-the-orofacial-and-dental-complex-in-crouzon-syndrome
#11
Alexander Khominsky, Robin Yong, Sarbin Ranjitkar, Grant Townsend, Peter J Anderson
OBJECTIVES: Fibroblast growth factor receptor 2 (FGFR2) C342Y/+ mutation is a known cause of Crouzon syndrome that is characterised by craniosynostosis and midfacial hypoplasia. Our aim was to conduct extensive phenotyping of the maxillary, mandibular and dental morphology associated with this mutation. MATERIALS AND METHODS: Morphometric data were obtained from 40 mice, representing two genotypes (Crouzon and wild-type) and two sexes (males and females) (n=10 in each group)...
October 27, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29223634/the-composite-palatal-island-flap-modification-of-an-existing-technique-to-reconstruct-the-maxillary-alveolus
#12
A Mosea
No abstract text is available yet for this article.
December 6, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/29213014/a-case-of-a-giant-mass-in-the-lumbar-region-of-a-newborn-calf
#13
Kazuki Yoshioka, Aika Ishikawa, Makoto Sugiyama, Jun Nagasao, Motohiro Kikuchi
The present report describes a newborn calf with spina bifida that presented with a giant mass of the lumbar region, as well as subsequent gross, histological, and immunohistochemical examinations. A malformed Japanese black calf (estimated weight = 20 kg) was euthanized immediately after birth. A gross evaluation revealed a giant mass (approximately 60 cm × 30 cm × 15 cm) covered by the hair coat in the lumbar region and connected with the hair coat of the trunk. The mass surface was divided by a deep polygonal groove and externally resembled a lobulated kidney...
2017: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/29195817/radial-plane-tooth-position-and-bone-wall-dimensions-in-the-anterior-maxilla-a-cbct-classification-for-immediate-implant-placement
#14
Howard Gluckman, Carla Cruvinel Pontes, Jonathan Du Toit
STATEMENT OF PROBLEM: The biological and esthetic challenge of the post-extraction ridge is relevant to restorative implant dentistry, most significantly in the anterior esthetic zone. Previous authors have discussed facial bone wall dimensions and classified their variations. A reclassification may be pertinent. PURPOSE: The purpose of this observational, clinical study was to introduce a new classification system for anterior maxilla tooth position with guidelines for immediate implant placement...
November 29, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29194721/initial-experiences-with-nam-assisted-primary-repair-of-the-bclp-deformity
#15
Sabarinath Prasad, Sreeja Ravindran, Vasanth Radhakrishnan, P V Hazarey, Amit Vanka, Bhavya Rajan
BACKGROUND: Primary surgical repair of the bilateral cleft lip and palate (BCLP) deformity is challenging. Infant Orthopedic (IO) procedures are often used to assist surgical reconstruction of normal anatomy. Nasoalveolar molding (NAM) is a presurgical infant orthopedic procedure that attempts to reduce the cleft nasal deformity, in addition to the lip and alveolus, leading to an esthetic primary surgical repair. OBJECTIVE: NAM provides the surgical team with a better foundation for an easier and more esthetic single stage repair at the level of nose in addition to the lip and alveolus...
December 1, 2017: Special Care in Dentistry
https://www.readbyqxmd.com/read/29192349/placement-of-an-antibiotic-oral-pack-on-the-hard-palate-after-primary-cleft-palatoplasty-a-randomized-controlled-trial-into-the-effect-on-fistula-rates
#16
Rajgopal R Reddy, Srinivas Gosla Reddy, Bhavya Banala, Ewald M Bronkhorst, Ann W Kummer, Anne Marie Kuijpers-Jagtman, Stefaan J Bergé
OBJECTIVE: The objective of this study is to determine whether placement of an antibiotic oral pack on the hard palate reduces fistula rates after primary cleft palatoplasty. SUBJECTS AND METHODS: This study was a parallel blocked randomized controlled trial. The study consisted of two groups of 100 patients each with non-syndromic unilateral complete cleft lip, alveolus, and hard and soft palate that underwent primary palatoplasty. Group A had an oral pack placed on the hard palate for 5 days postoperatively while group B did not...
November 30, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29184405/absence-of-lung-fibrosis-after-a-single-pulmonary-delivery-of-lipid-nanocapsules-in-rats
#17
José Hureaux, Franck Lacoeuille, Frédéric Lagarce, Marie-Christine Rousselet, Aurélien Contini, Patrick Saulnier, Jean-Pierre Benoit, Thierry Urban
Lipid nanocapsules (LNCs) are potential drug carriers for pulmonary delivery since they can be nebulized without any structural or functional changes, and the aerosols produced are highly compatible with pulmonary drug delivery in human beings. The alveolar surface tension, in vitro cytotoxicity, biodistribution and pulmonary toxicity in rats of a single endotracheal spray of LNCs or paclitaxel-loaded LNCs were studied. In vitro cytotoxicity of LNCs after a spray remained unchanged. Biodistribution study showed a homogeneous repartition in the lungs in rats with an improvement in lung retention of the radiolabeled tracer loaded in LNCs compared to the absence of LNCs with a lung half-time of 8...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29175081/epithelial-mesenchymal-crosstalk-influences-cellular-behavior-in-a-3d-alveolus-fibroblast-model-system
#18
Katherine J R Lewis, Jessica K Hall, Emi A Kiyotake, Tova Christensen, Vivek Balasubramaniam, Kristi S Anseth
Interactions between lung epithelium and interstitial fibroblasts are increasingly recognized as playing a major role in the progression of several lung pathologies, including cancer. Three-dimensional in vitro co-culture systems offer tissue-relevant platforms to study the signaling interplay between diseased and healthy cell types. Such systems provide a controlled environment in which to probe the mechanisms involved in epithelial-mesenchymal crosstalk. To recapitulate the native alveolar tissue architecture, we employed a cyst templating technique to culture alveolar epithelial cells on photodegradable microspheres and subsequently encapsulated the cell-laden spheres within poly (ethylene glycol) (PEG) hydrogels containing dispersed pulmonary fibroblasts...
February 2018: Biomaterials
https://www.readbyqxmd.com/read/29157548/imaging-of-benign-odontogenic-lesions
#19
REVIEW
William C Scarfe, Shiva Toghyani, Bruno Azevedo
Numerous benign cysts or solid tumors may present in the jaws. These arise from tooth-forming tissues in the dental alveolus or from nonodontogenic tissues in the basal bone of the mandible and maxilla. Radiologists provide 2 deliverables to assist in diagnosis and management: (1) appropriately formatted images demonstrating the location and extent of the lesion and (2) interpretive reports highlighting specific radiologic findings and an impression providing a radiologic differential diagnosis. This article provides guidance on essential image protocols for planning treatments, a radiologic differential diagnostic algorithm based on location and pattern recognition, and a summary of the main features of benign odontogenic lesions...
January 2018: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/29110549/a-104-week-pulmonary-toxicity-assessment-of-long-and-short-single-wall-carbon-nanotubes-after-a-single-intratracheal-instillation-in-rats
#20
Kazumasa Honda, Masato Naya, Hiroshi Takehara, Hiromichi Kataura, Katsuhide Fujita, Makoto Ema
We compared long-term pulmonary toxicities after a single intratracheal instillation of two types of dispersed single-wall carbon nanotubes (SWCNTs), namely, those with relatively long or short linear shapes with average lengths of 8.6 and 0.55 µm, respectively. Both types of SWCNTs were instilled intratracheally in male F344 rats at 0.2 or 1.0 mg/kg (long SWCNTs) or 1.0 mg/kg (short SWCNTs). Pulmonary responses were characterized at 26, 52 and 104 weeks after a single instillation. Inflammatory changes, test substance deposition, test substance engulfment by macrophages, and alveolar wall fibrosis were observed in the lungs of almost all test rats at 52 and 104 weeks after short nanotube instillation...
November 7, 2017: Inhalation Toxicology
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