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https://www.readbyqxmd.com/read/29346438/colonization-of-the-cervicovaginal-space-with-gardnerella-vaginalis-leads-to-local-inflammation-and-cervical-remodeling-in-pregnant-mice
#1
Luz-Jeannette Sierra, Amy G Brown, Guillermo O Barilá, Lauren Anton, Carrie E Barnum, Snehal S Shetye, Louis J Soslowsky, Michal A Elovitz
The role of the cervicovaginal (CV) microbiome in regulating cervical function during pregnancy is poorly understood. Gardnerella vaginalis (G. vaginalis) is the most common bacteria associated with the diagnosis of bacterial vaginosis (BV). While BV has been associated with preterm birth (PTB), clinical trials targeting BV do not decrease PTB rates. It remains unknown if G. vaginalis is capable of triggering molecular, biomechanical and cellular events that could lead to PTB. The objective of this study was to determine if cervicovaginal colonization with G...
2018: PloS One
https://www.readbyqxmd.com/read/29346158/biomechanical-response-to-osteoarthritis-pain-treatment-may-impair-long-term-efficacy
#2
Katherine A Boyer
Pain has an important physiologic role and acts with and/or stimulates motor system adaptations to protect tissue from threats of damage. While clinically beneficial, removing the protective pain response may have negative consequence in osteoarthritis, a mechanically-mediated disease. We hypothesize motor system adaptations to joint pain and its treatment may impact osteoarthritis progression thereby limiting efficacy of pain therapies.
January 15, 2018: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/29345514/design-and-validation-of-an-instrumented-uneven-terrain-treadmill
#3
Alexandra S Voloshina, Daniel P Ferris
Studying human and animal locomotion on uneven terrain can be beneficial to basic science and applied studies for clinical and robotic applications. Traditional biomechanical analysis of human locomotion has often been limited to laboratory environments with flat, smooth runways and treadmills. We modified a regular exercise treadmill by attaching wooden blocks to the treadmill belt to yield an uneven locomotion surface. To ensure that these treadmill modifications facilitated biomechanical measurements, we compared ground reaction force data collected during running on the modified instrumented treadmill with a smooth surface to data collected using a conventional instrumented treadmill...
January 18, 2018: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/29345399/glycine-improves-the-remodeling-process-of-tenocytes-in-vitro
#4
Cristiano Pedrozo Vieira, Manuela Viola, Giane Daniela Carneiro, Maria Luisa D'Angelo, Cristina Pontes Vicente, Alberto Passi, Edson Rosa Pimentel
Tendinitis changes the biochemical and morphological properties of the tendon, promoting an increase of activity of metalloproteinases and disorganization of collagen bundles. Tenocytes the primary cells in tendon, are scattered throughout the collagenic fibres, and are responsible of tendon remodeling and tissue repair in pathological condition. In vivo, glycine, component of the typical Gly-X-Y collagen tripeptide, showed beneficial effects in biochemical and biomechanical properties of Achilles tendon with tendinitis...
January 18, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29343719/the-significant-role-of-c-abl-kinase-in-barrier-altering-agonists-mediated-cytoskeletal-biomechanics
#5
X Wang, L Wang, J G N Garcia, S M Dudek, G S Shekhawat, V P Dravid
Exploration of human pulmonary artery endothelial cell (EC) as a prototypical biomechanical system has important pathophysiologic relevance because this cell type plays a key role in the development of a wide variety of clinical conditions. The complex hierarchical organization ranging from the molecular scale up to the cellular level has an intimate and intricate relationship to the barrier function between lung tissue and blood. To understand the innate molecule-cell-tissue relationship across varied length-scales, the functional role of c-Abl kinase in the cytoskeletal nano-biomechanics of ECs in response to barrier-altering agonists was investigated using atomic force microscopy...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343182/fibronectin-enhances-cartilage-repair-by-activating-progenitor-cells-through-integrin-%C3%A9-5%C3%AE-1-receptor
#6
Tianqi Tao, Yang Li, Chang Gui, Yong Ma, Yingbin Ge, Hanhao Dai, Kaibin Zhang, Jing Du, Yang Guo, Yiqiu Jiang, Jianchao Gui
This study aimed to determine the effect of fibronectin (FN) on cartilage regeneration through the activation of chondrogenic progenitor cells (CPCs). Cells were isolated from the knee cartilage of mice and cultured in the presence of various concentrations of FN. Proliferation, migration and chondrogenic differentiation assays were performed in vitro. In some experiments, CPCs were pre-incubated with anti-integrin ɑ5β1 antibody for 60 min prior to FN treatment to block the integrin ɑ5β1 receptor. Soluble FN was mixed with Pluronic F-127 and injected into the joint cavity in an early-stage osteoarthritis (OA) model...
January 18, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29342830/methods-to-improve-osseointegration-of-dental-implants-in-low-quality-type-iv-bone-an-overview
#7
REVIEW
Hamdan S Alghamdi
Nowadays, dental implants have become more common treatment for replacing missing teeth and aim to improve chewing efficiency, physical health, and esthetics. The favorable clinical performance of dental implants has been attributed to their firm osseointegration, as introduced by Brånemark in 1965. Although the survival rate of dental implants over a 10-year observation has been reported to be higher than 90% in totally edentulous jaws, the clinical outcome of implant treatment is challenged in compromised (bone) conditions, as are frequently present in elderly people...
January 13, 2018: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/29342321/contributions-of-material-properties-and-structure-to-increased-bone-fragility-for-a-given-bone-mass-in-the-ucd-t2dm-rat-model-of-type-2-diabetes
#8
Claire Acevedo, Meghan Sylvia, Eric Schaible, James L Graham, Kimber L Stanhope, Lionel N Metz, Bernd Gludovatz, Ann V Schwartz, Robert O Ritchie, Tamara N Alliston, Peter J Havel, Aaron J Fields
Adults with type 2 diabetes (T2D) have a higher fracture risk for a given bone quantity, but the mechanisms remain unclear. Using a rat model of polygenic obese T2D, we demonstrate that diabetes significantly reduces whole-bone strength for a given bone mass (micro-CT-derived BMC), and we quantify the roles of T2D-induced deficits in material properties versus bone structure, i.e., geometry and microarchitecture. Lumbar vertebrae and ulnae were harvested from 6-month-old lean Sprague-Dawley rats, obese Sprague-Dawley rats, and diabetic obese UCD-T2DM rats (diabetic for 69 ± 7 days; blood glucose >200 mg/dl)...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29342060/creep-and-wear-in-vitamin-e-infused-highly-cross-linked-polyethylene-cups-for-total-hip-arthroplasty-a-prospective-randomized-controlled-trial
#9
G Rochcongar, G Buia, E Bourroux, J Dunet, V Chapus, C Hulet
BACKGROUND: Aseptic loosening, the most common indication for revision surgery in total hip arthroplasty, can result from osteolysis caused by polyethylene (PE) wear particles. PE wear is increased by age-related oxidation of PE and free radicals emerging during irradiation cross-linking. Diffusion of vitamin E into PE stabilizes free radicals to maintain the biomechanical properties of PE. The purpose of this study was to determine whether vitamin E-infused highly cross-linked PE cups could reduce wear rates...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29341975/validation-of-a-simplified-implant-retained-cantilever-fixed-prosthesis
#10
João Paulo Mendes Tribst, Vinícius Anéas Rodrigues, Alexandre Luiz Souto Borges, Dimas Rennó de Lima, Renato Sussumu Nishioka
PURPOSE: To evaluate the stress and strain generated in a fixed four-element prosthesis under the application of axial and nonaxial loads using a simplified implant-supported fixed prosthesis model. MATERIALS AND METHODS: A 3-dimensional model was constructed containing 3 implants with a conventional anatomical prosthesis (G1). The second model with the same implant system received the simplified prosthesis (G2). A load of 300 N was applied at an axial point and a nonaxial point through finite element analysis software...
January 16, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29341426/biomechanical-histological-and-computed-x-ray-tomographic-analyses-of-hydroxyapatite-coated-peek-implants-in-an-extended-healing-model-in-rabbit
#11
Pär Johansson, Sargon Barkarmo, Mohammed Hawthan, Niccolò Peruzzi, Per Kjellin, Ann Wennerberg
No abstract text is available yet for this article.
January 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29340745/a-6-week-warm-up-injury-prevention-programme-results-in-minimal-biomechanical-changes-during-jump-landings-a-randomized-controlled-trial
#12
Jeffrey B Taylor, Kevin R Ford, Randy J Schmitz, Scott E Ross, Terry A Ackerman, Sandra J Shultz
PURPOSE: To examine the extent to which an ACL injury prevention programme modifies lower extremity biomechanics during single- and double-leg landing tasks in both the sagittal and frontal plane. It was hypothesized that the training programme would elicit improvements in lower extremity biomechanics, but that these improvements would be greater during a double-leg sagittal plane landing task than tasks performed on a single leg or in the frontal plane. METHODS: Ninety-seven competitive multi-directional sport athletes that competed at the middle- or high-school level were cluster randomized into intervention (n = 48, age = 15...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29340639/biomechanical-rigidity-and-quantitative-proteomics-analysis-of-segmental-regions-of-the-trabecular-meshwork-at-physiologic-and-elevated-pressures
#13
Janice A Vranka, Julia A Staverosky, Ashok P Reddy, Phillip A Wilmarth, Larry L David, Ted S Acott, Paul Russell, Vijay Krishna Raghunathan
Purpose: The extracellular matrix (ECM) of the trabecular meshwork (TM) modulates resistance to aqueous humor outflow, thereby regulating IOP. Glaucoma, a leading cause of irreversible blindness worldwide, is associated with changes in the ECM of the TM. The elastic modulus of glaucomatous TM is larger than age-matched normal TM; however, the biomechanical properties of segmental low (LF) and high flow (HF) TM regions and their response to elevated pressure, are unknown. Methods: We perfused human anterior segments at two pressures using an ex vivo organ culture system...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29340634/efficient-decellularization-for-bovine-pericardium-with-extracellular-matrix-preservation-and-good-biocompatibility
#14
Ning Li, Yang Li, Dejun Gong, Cuiping Xia, Xiaohong Liu, Zhiyun Xu
OBJECTIVES: In this study, we sought to explore an efficient decellularization protocol for bovine pericardia with better extracellular matrix preservation and good biocompatibility. METHODS: Bovine pericardia were decellularized by sodium dodecyl sulphate (SDS), SDS + sodium deoxycholate (SD), Triton X-100 (TX), TX + SD (TS), freeze-thaw cycles + SDS + SD (FSS) and freeze-thaw cycles + TX + SD (FTS), respectively. Untreated pericardia were used as native control...
January 10, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29340344/biomechanical-comparison-of-different-implant-inclinations-and-cantilever-lengths-in-all-on-4-treatment-concept-by-three-dimensional-finite-element-analysis
#15
Oguz Ozan, Sevcan Kurtulmus-Yilmaz
PURPOSE: The aim of this study was to evaluate the effect of implant inclination and cantilever length on the stress distribution in mandibular cortical bone, implant, abutment, prosthetic framework, and prosthetic screw via three-dimensional (3D) finite element analysis (FEA). MATERIALS AND METHODS: Four different finite element models (0-0, 17-17, 30-30, 45-30) were designed according to the tilting angle (0, 17, 30, and 45 degrees) of the posterior implant and angle of multiunit abutments (0, 17, and 30 degrees)...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29339984/functional-vs-traditional-analysis-in-biomechanical-gait-data-an-alternative-statistical-approach
#16
Jihong Park, Matthew K Seeley, Devin Francom, C Shane Reese, J Ty Hopkins
In human motion studies, discrete points such as peak or average kinematic values are commonly selected to test hypotheses. The purpose of this study was to describe a functional data analysis and describe the advantages of using functional data analyses when compared with a traditional analysis of variance (ANOVA) approach. Nineteen healthy participants (age: 22 ± 2 yrs, body height: 1.7 ± 0.1 m, body mass: 73 ± 16 kg) walked under two different conditions: control and pain+effusion. Pain+effusion was induced by injection of sterile saline into the joint capsule and hypertonic saline into the infrapatellar fat pad...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339488/ultrafast-imaging-of-cell-elasticity-with-optical-microelastography
#17
Pol Grasland-Mongrain, Ali Zorgani, Shoma Nakagawa, Simon Bernard, Lia Gomes Paim, Greg Fitzharris, Stefan Catheline, Guy Cloutier
Elasticity is a fundamental cellular property that is related to the anatomy, functionality, and pathological state of cells and tissues. However, current techniques based on cell deformation, atomic force microscopy, or Brillouin scattering are rather slow and do not always accurately represent cell elasticity. Here, we have developed an alternative technique by applying shear wave elastography to the micrometer scale. Elastic waves were mechanically induced in live mammalian oocytes using a vibrating micropipette...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29339193/a-pilot-study-on-the-biomechanical-assessment-of-obstructive-sleep-apnea-pre-and-post-bariatric-surgery
#18
Ahmed M Al-Jumaily, Sherif Ashaat, Bryn Martin, Rachael Pohle-Krauza, Matthew Krauza, Adrian Dan, John Zografakis
Obesity is a major risk factor for obstructive sleep apnea patients. In obese patients the severity of this risk can be reduced by bariatric surgery. This pilot study investigates the perioperative effects of bariatric surgery on obstructive sleep apnea and on the physical and biomechanical characteristics of the upper airway. Polysomnography and computer tomography data for 10 morbid obese patients promoted for bariatric surgery were conducted before surgery and at 6 and 12 months postoperatively for assessment of the oropharyngeal anatomy, and subsequent three-dimensional modelling of the airway...
January 12, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29339174/the-impact-of-strabismus-surgery-on-gait-pattern-in-patients-with-congenital-or-starting-within-one-year-of-age-strabismus
#19
Enrica Sipio, Anna Dickmann, Irene Aprile, Marco Germanotta, Chiara Simbolotti, Annabella Salerni, Gustavo Savino, Luca Padua
Strabismus is a common visual disorder that negatively affects walking and balance. Therapeutic interventions for strabismus include strabismus surgery. Few studies investigated the relationship between strabismus surgery and postural control while, to the best of our knowledge, none has been conducted to assess the influence of strabismus surgery on gait. Therefore, the aim of this study was to evaluate the locomotion characteristics over patients with congenital or starting within one year of age strabismus, one month and three months after strabismus surgery...
January 12, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29339002/development-of-a-new-three-directional-distractor-system-for-the-correction-of-maxillary-transverse-and-sagittal-deficiency
#20
Canay Yılmaz Asan, Nükhet Kütük, Gökmen Kurt, Alper Alkan
PURPOSE: Class 3 malocclusions with maxillary deficiency, which are treated surgically and/or ordonotically, are common among adult patients. The aim of this study was to develop a three-directional bone-borne distractor that would allow the transverse expansion and sagittal advancement of the maxilla simultaneously. MATERIALS AND METHODS: Computed tomography images of a patient with maxillary deficiency were transmitted to a software program, and a distractor was designed with different sizes (D1, D2, D3) and manufactured from titanium alloy...
December 18, 2017: Journal of Cranio-maxillo-facial Surgery
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