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https://www.readbyqxmd.com/read/28528404/a-direct-comparison-of-the-effects-of-the-antiretroviral-drugs-stavudine-tenofovir-and-the-combination-lopinavir-ritonavir-on-bone-metabolism-in-a-rat-model
#1
M M Conradie, M van de Vyver, E Andrag, M Conradie, W F Ferris
Antiretroviral (ARV) treatment may induce metabolic complications in HIV patients on long-term therapy that can affect bone health. In this study, the effects of the ARVs Stavudine (d4T), Tenofovir (TDF) and Lopinavir/ritonavir (LPV/r) on bone metabolism and lipodystrophy were directly compared in rats to negate the consequences of HIV-associated confounding factors. Healthy 12-14-week-old male Wistar rats (n = 40) were divided into four treatment groups and received an oral animal equivalent dose of either Stavudine (6...
May 20, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28528004/potential-contributions-of-skeletal-muscle-contractile-dysfunction-to-altered-biomechanics-in-obesity
#2
REVIEW
Lance M Bollinger
Obesity alters whole body kinematics and joint kinetics during activities of daily living which are thought to contribute to increased risk of musculoskeletal injury, development of lower extremity joint osteoarthritis (OA), and physical disability. To date, it has widely been accepted that excess adipose tissue mass is the major driver of biomechanical alterations in obesity. However, it is well established that obesity is a systemic disease affecting numerous, if not all, organ systems of the body. Indeed, obesity elicits numerous adaptations within skeletal muscle, including alterations in muscle structure (ex...
May 13, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28527840/prevalence-of-middle-mesial-canals-and-isthmi-in-the-mesial-root-of-mandibular-molars-an-in%C3%A2-vivo-cone-beam-computed-tomographic-study
#3
Mehrnaz Tahmasbi, Poorya Jalali, Madhu K Nair, Sevin Barghan, Umadevi P Nair
INTRODUCTION: Many studies have investigated the morphology of the mandibular molar, but the prevalence of the middle mesial (MM) canal in the mesial root of the mandibular molar is still the subject of controversy. In addition, in previous literature, a true MM canal has not been clearly distinguished from an isthmus between the mesiobuccal and mesiolingual canals. Therefore, the objectives of this study were 2-fold: METHODS: Ninety limited field of view cone-beam computed tomographic scans were observed...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28527835/biomechanical-study-on-surgical-fixation-methods-for-minimally-invasive-treatment-of-hallux-valgus
#4
Rui Mao, Junchao Guo, Chenyu Luo, Yubo Fan, Jianmin Wen, Lizhen Wang
Hallux valgus (HV) was one of the most frequent female foot deformities. The aim of this study was to evaluate mechanical responses and stabilities of the Kirschner, bandage and fiberglass fixations after the distal metatarsal osteotomy in HV treatment. Surface traction of different forefoot regions in bandage fixation and the biomechanical behavior of fiberglass bandage material were measured by a pressure sensor device and a mechanical testing, respectively. A three-dimensional foot finite element (FE) model was developed to simulate the three fixation methods (Kirschner, bandage and fiberglass fixations) in weight bearing...
May 17, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28527594/whole-globe-biomechanics-using-high-field-mri
#5
Andrew P Voorhees, Leon C Ho, Ning-Jiun Jan, Huong Tran, Yolandi van der Merwe, Kevin Chan, Ian A Sigal
The eye is a complex structure composed of several interconnected tissues acting together, across the whole globe, to resist deformation due to intraocular pressure (IOP). However, most work in the ocular biomechanics field only examines the response to IOP over smaller regions of the eye. We used high-field MRI to measure IOP induced ocular displacements and deformations over the whole globe. Seven sheep eyes were obtained from a local abattoir and imaged within 48 h using MRI at multiple levels of IOP. IOP was controlled with a gravity perfusion system and a cannula inserted into the anterior chamber...
May 17, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28527232/three-dimensional-evaluation-of%C3%A2-postural%C3%A2-stability-in-parkinson-s-disease-with-mobile-technology
#6
Sarah J Ozinga, Mandy Miller Koop, Susan M Linder, Andre G Machado, Tanujit Dey, Jay L Alberts
BACKGROUND: Postural instability is a hallmark of Parkinson's disease. Objective metrics to characterize postural stability are necessary for the development of treatment algorithms to aid in the clinical setting. OBJECTIVE: The aim of this project was to validate a mobile device platform and resultant three-dimensional balance metric that characterizes postural stability. METHODS: A mobile Application was developed, in which biomechanical data from inertial sensors within a mobile device were processed to characterize movement of center of mass in the medial-lateral, anterior-posterior and trunk rotation directions...
May 13, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28526627/dynamic-fatigue-measurement-of-human-erythrocytes-using-dielectrophoresis
#7
Yuhao Qiang, Jia Liu, E Du
Erythrocytes must undergo severe deformation to pass through narrow capillaries and submicronic splenic slits for several hundred thousand times in their normal lifespan. Studies of erythrocyte biomechanics have been mainly focused on cell deformability and rheology measured from a single application of stress and mostly under a static or quasi-static state using classical biomechanical techniques, such as optical tweezers and micropipette aspiration. Dynamic behavior of erythrocytes in response to cyclic stresses that contributes to the membrane failure in blood circulation is not fully understood...
May 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28526290/hominoid-arcade-shape-pattern-and-magnitude-of-covariation
#8
Stefanie Stelzer, Philipp Gunz, Simon Neubauer, Fred Spoor
The shape of the dental arcade and canine size distinguish extant humans from all apes. Humans are characterized by a parabolic arcade with short postcanine tooth rows and small canines, whereas apes have long, U-shaped arcades with large canines. The evolutionary and biomechanical mechanisms underlying arcade shape differences between and within groups are not well understood. It is unclear, for example, whether evolutionary changes in the covariation among modules comprising the upper and lower jaws are the cause and/or consequence of different arcade shapes...
June 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28526023/high-incidence-of-periprosthetic-joint-infection-with-propionibacterium-acnes-after-the-use-of-a-stemless-shoulder-prosthesis-with-metaphyseal-screw-fixation-a-retrospective-cohort-study-of-241-patients-propionibacter-infections-after-eclipse-tsa
#9
Lisa Johansson, Nils P Hailer, Hans Rahme
BACKGROUND: A stemless shoulder prosthesis with humeral metaphyseal screw fixation was introduced in order to save bone-stock and to facilitate reconstruction of biomechanics (Eclipse®). The aim of this study was to analyze whether the risk of infection is different with this implant compared to conventional shoulder prosthesis. METHODS: Two hundred and forty-one patients (54.8% females) were operated with a shoulder arthroplasty and followed for median 2.0 (0...
May 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28525774/development-and-validation-of-a-physical-model-to-investigate-the-biomechanics-of-infant-head-impact
#10
M Jones, D Darwall, G Khalid, R Prabhu, A Kemp, O Arthurs, P Theobald
Head injury in childhood is the single most common cause of death or permanent disability from injury. However, despite its frequency and significance, there is little understanding of the response of a child's head to injurious loading. This is a significant limitation when making early diagnoses, informing clinical and/or forensic management or injury prevention strategies. With respect to impact vulnerability, current understanding is predominantly based on a few post-mortem-human-surrogate (PMHS) experiments...
April 13, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28525483/development-of-a-remodeled-caspar-retractor-and-its-application-in-the-measurement-of-distractive-resistance-in-an-in-vitro-anterior-cervical-distraction-model
#11
Junxiang Wen, Jianwei Xu, Lijun Li, Mingjie Yang, Jie Pan, Deyu Chen, Lianshun Jia, Jun Tan
STUDY DESIGN: In vitro biomechanical study of the cervical intervertebral distraction using a remodeled Caspar retractor. OBJECTIVE: To investigate the torques required for distraction to different heights in an in vitro C3-C4 anterior cervical distraction model using a remodeled Caspar retractor, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). SUMMARY OF BACKGROUND DATA: No previous studies have reported on the torques required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525481/comparison-of-the-clinical-and-radiographic-results-between-cervical-artificial-disk-replacement-and-anterior-cervical-fusion-a-6-year-prospective-nonrandomized-comparative-study
#12
Wei Tian, Kai Yan, Xiao Han, Jie Yu, Peihao Jin, Xiaoguang Han
STUDY DESIGN: Prospective nonrandomized comparative study. OBJECTIVE: To compare the long-term clinical and radiographic results of cervical artificial disk replacement (CADR) and anterior cervical discectomy and fusion (ACDF), and to provide our evidence if CADR could reduce adjacent segment degeneration (ASD). SUMMARY OF BACKGROUND DATA: CADR is widely used in spine surgery today. Despite the short-term results of it having been ascertained, the long-term results are still under observation...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525470/factors-affecting-the-nonlinear-force-versus-distraction-height-curves-in-an-in-vitro-c5-c6-anterior-cervical-distraction-model
#13
Junxiang Wen, Jianwei Xu, Lijun Li, Mingjie Yang, Jie Pan, Deyu Chen, Lianshun Jia, Jun Tan
STUDY DESIGN: In vitro biomechanical study of cervical intervertebral distraction. OBJECTIVE: To investigate the forces required for distraction to different heights in an in vitro C5-C6 anterior cervical distraction model, focusing on the influence of the intervertebral disk, posterior longitudinal ligament (PLL), and ligamentum flavum (LF). SUMMARY OF BACKGROUND DATA: No previous studies have reported on the forces required for distraction to various heights or the factors resisting distraction in anterior cervical discectomy and fusion...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28525468/cortical-bone-trajectory-for-thoracic-pedicle-screws-a-technical-note
#14
Keitaro Matsukawa, Yoshiyuki Yato, Richard A Hynes, Hideaki Imabayashi, Naobumi Hosogane, Takashi Asazuma, Toshiyasu Matsui, Yasushi Kobayashi, Koichi Nemoto
STUDY DESIGN: A morphometric measurement of new thoracic pedicle screw trajectory using computed tomography and a biomechanical study on cadaveric thoracic vertebrae using insertional torque. OBJECTIVE: To introduce a new thoracic pedicle screw trajectory which maximizes engagement with denser bone. SUMMARY OF BACKGROUND DATA: Cortical bone trajectory (CBT) which maximizes the thread contact with cortical bone provides enhanced screw purchase...
June 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28523981/classification-of-lunge-biomechanics-with-multiple-and-individual-inertial-measurement-units
#15
Martin A O'Reilly, Darragh F Whelan, Tomas E Ward, Eamonn Delahunt, Brian Caulfield
Lunges are a common, compound lower limb resistance exercise. If completed with aberrant technique, the increased stress on the joints used may increase risk of injury. This study sought to first investigate the ability of inertial measurement units (IMUs), when used in isolation and combination, to (a) classify acceptable and aberrant lunge technique (b) classify exact deviations in lunge technique. We then sought to investigate the most important features and establish the minimum number of top-ranked features and decision trees that are needed to maintain maximal system classification efficacy...
May 19, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28522238/biomechanical-comparison-of-four-coupled-fixation-systems-for-acl-reconstruction-with-bone-socket-or-full-tunnel-on-the-tibial-side
#16
Edoardo Monaco, Mattia Fabbri, Riccardo Maria Lanzetti, Andrea Del Duca, Luca Labianca, Andrea Ferretti
BACKGROUND: To compare in an animal model the biomechanical properties of four coupled fixation devices currently used in ACL reconstruction. Three out of four devices used a full tibial tunnel with an interference screw, while the other one system used a tibial socket and an adjustable loop suspension device. The null hypothesis is that there are no biomechanical differences between all the techniques tested. METHODS: Thirty two femur-graft-tibia complexes were mounted on a tensile machine using bovine digital extensor tendons, porcine knees and four different fixation device combinations: After a preconditioning with a tensile load of 90N for five minutes, 1000cycles between 0 and 150N were applied to the complex before the final pulled to failure...
May 15, 2017: Knee
https://www.readbyqxmd.com/read/28520764/rib-biomechanical-properties-exhibit-diagnostic-potential-for-accurate-ageing-in-forensic-investigations
#17
Andrea Bonicelli, Bledar Xhemali, Elena F Kranioti, Peter Zioupos
Age estimation remains one of the most challenging tasks in forensic practice when establishing a biological profile of unknown skeletonised remains. Morphological methods based on developmental markers of bones can provide accurate age estimates at a young age, but become highly unreliable for ages over 35 when all developmental markers disappear. This study explores the changes in the biomechanical properties of bone tissue and matrix, which continue to change with age even after skeletal maturity, and their potential value for age estimation...
2017: PloS One
https://www.readbyqxmd.com/read/28520678/anterior-cruciate-ligament-injury-at-the-time-of-anterior-tibial-spine-fracture-in-young-patients-an-observational-cohort-study
#18
Meredith H Mayo, Justin J Mitchell, Derek P Axibal, Jorge Chahla, Claire Palmer, Armando F Vidal, Jason T Rhodes
BACKGROUND: Anterior tibial spine fractures (ATSF) in the skeletally immature parallel anterior cruciate ligament (ACL) tears in adult patients, yet these injuries are generally regarded as mutually exclusive. Biomechanical analysis suggests that intrinsic ACL damage occurs during ATSF, and long-term clinical studies demonstrate residual anteroposterior knee laxity following ATSF. We aim to describe prevalence, demographics, and characteristics of pediatric patients who sustained ATSF with concomitant ACL injury...
May 17, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28520556/breast-tissue-stiffness-estimation-for-surgical-guidance-using-gravity-induced-excitation
#19
Rebekah H Griesenauer, Jared A Weis, Lori R Arlinghaus, Ingrid M Meszoely, Michael I Miga
Tissue stiffness interrogation is fundamental in breast cancer diagnosis and treatment. Furthermore, biomechanical models for predicting breast deformations have been created for several breast cancer applications. Within these applications, constitutive mechanical properties must be defined and the accuracy of this estimation directly impacts the overall performance of the model. In this study, we present an image-derived computational framework to obtain quantitative, patient specific stiffness properties for application in image-guided breast cancer surgery and interventions...
May 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28520458/anchored-transosseous-equivalent-versus-anchorless-transosseous-rotator-cuff-repair-a-biomechanical-analysis-in-a-cadaveric-model
#20
Kelly G Kilcoyne, Stanley G Guillaume, Catherine V Hannan, Evan R Langdale, Stephen M Belkoff, Uma Srikumaran
BACKGROUND: The original approach for the repair of torn rotator cuffs involved an open technique with sutures passing through the greater tuberosity and tendon. The development of suture anchors allowed for an all-arthroscopic approach with anchor configurations attempting to re-create a transosseous fixation pattern. Presently, an arthroscopic approach can be combined with a transosseous suture configuration without using anchors. PURPOSE: To evaluate cyclic loading, ultimate load to failure, and the failure mechanisms of transosseous-equivalent (TOE) repair with anchors and anchorless transosseous (AT) repair of rotator cuff tears...
May 1, 2017: American Journal of Sports Medicine
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