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Tatenda C Nzenza, Yahya Al-Habbal, Glen R Guerra, S Manolas, Tuck Yong, Trevor McQuillan
BACKGROUND: Endoscopic retrograde cholangiopancreatography (ERCP) with endoscopic sphincterotomy (ES) has become well established as a modality for the management of common bile duct stones (CBDS), especially in the setting of associated cholangitis. Our study aims to determine the rate of long term morbidity of recurrent CBDS post ES. METHODS: A retrospective analysis of patients who underwent ERCP and ES (ERCP+ES) was undertaken on a prospectively maintained database from 1998 to 2012 at the Northern Hospital, Melbourne...
March 15, 2018: BMC Gastroenterology
You-Cai Zhu, Yue-Fen Zhou, Wen-Xian Wang, Chun-Wei Xu, Wu Zhuang, Kai-Qi Du, Gang Chen
ROS1 rearrangement is a validated therapeutic driver gene in non-small cell lung cancer (NSCLC) and represents a small subset (1-2%) of NSCLC. A total of 17 different fusion partner genes of ROS1 in NSCLC have been reported. The multi-targeted MET/ALK/ROS1 tyrosine kinase inhibitor (TKI) crizotinib has demonstrated remarkable efficacy in ROS1-rearranged NSCLC. Consequently, ROS1 detection assays include fluorescence in situ hybridization, immunohistochemistry, and real-time PCR. Next-generation sequencing (NGS) assay covers a range of fusion genes and approaches to discover novel receptor-kinase rearrangements in lung cancer...
March 8, 2018: Thoracic Cancer
Melanie A Holden, Kim L Bennell, Rebecca Whittle, Linda Chesterton, Nadine E Foster, Nicola A Halliday, Libby N Spiers, Elizabeth M Mason, Jonathan G Quicke, Christian D Mallen
Background: Hip osteoarthritis (OA) is common, painful and disabling. Physical therapists have an important role in managing patients with hip OA, however little is known about their current management approach and whether it aligns with clinical guideline recommendations. Objective: The objective of this study is to describe UK physical therapists' current management of patients with hip OA and to determine whether it aligns with clinical guidelines. Design: The design is a cross-section questionnaire...
March 4, 2018: Physical Therapy
Kylie Elizabeth Hunter, Anna Lene Seidler, Lisa M Askie
OBJECTIVES: To analyse prospective versus retrospective trial registration trends on the Australian New Zealand Clinical Trials Registry (ANZCTR) and to evaluate the reasons for non-compliance with prospective registration. DESIGN: Part 1: Descriptive analysis of trial registration trends from 2006 to 2015. Part 2: Online registrant survey. PARTICIPANTS: Part 1: All interventional trials registered on ANZCTR from 2006 to 2015. Part 2: Random sample of those who had retrospectively registered a trial on ANZCTR between 2010 and 2015...
March 1, 2018: BMJ Open
Yanyan Liu, Okechukwu C Ndumnego, Tingting Chen, Ryung S Kim, Elizabeth R Jenny-Avital, Thumbi Ndung'u, Douglas Wilson, Jacqueline M Achkar
Sputum smear-negative HIV-associated active tuberculosis (TB) is challenging to diagnose. CD14 is a pattern recognition receptor that is known to mediate monocyte activation. Prior studies have shown increased levels of soluble CD14 (sCD14) as a potential biomarker for TB, but little is known about its value in detecting smear-negative HIV-associated TB. We optimized a sandwich ELISA for the detection of sCD14, and tested sera from 56 smear-negative South African (39 culture-positive and 17 culture-negative) HIV-infected pulmonary TB patients and 24 South African and 43 US (21 positive and 22 negative for tuberculin skin test, respectively) HIV-infected controls...
February 27, 2018: Pathogens
Archana Mishra, Akash Kumar, Sanjoy Ghosh
Impact of second-generation ethanol (2G) use in transportation sector mainly depends upon energy efficiency of entire production process. The objective of present study was to determine energy efficiency of a potential lignocellulosic feedstock; wheat straw and its conversion into cellulosic ethanol in Indian scenario. Energy efficiency was determined by calculating Net energy ratio (NER), i.e. ratio of output energy obtained by ethanol and input energy used in ethanol production. Energy consumption and generation at each step is calculated briefly (11,837...
March 2018: 3 Biotech
Charles Daultrey, John Hardman, Shahram Anari
Background: The nasal septum is composed of cartilaginous and bony components and an understanding of each component volume is essential in both functional and cosmetic surgery. Objectives: We sought to radiographically measure septal dimensions on cross sectional computer tomography (CT) images, establishing average parameters for normal anatomy among a single, Caucasian population group. Methods: One hundred and fifty consecutive sinus CT scan images were examined and 100 cases with appropriate sagittal views were included in the study...
February 19, 2018: Aesthetic Surgery Journal
Sören Verstraete, Ilse Vanhorebeek, Esther van Puffelen, Inge Derese, Catherine Ingels, Sascha C Verbruggen, Pieter J Wouters, Koen F Joosten, Jan Hanot, Gonzalo G Guerra, Dirk Vlasselaers, Jue Lin, Greet Van den Berghe
BACKGROUND: Children who have suffered from critical illnesses that required treatment in a paediatric intensive care unit (PICU) have long-term physical and neurodevelopmental impairments. The mechanisms underlying this legacy remain largely unknown. In patients suffering from chronic diseases hallmarked by inflammation and oxidative stress, poor long-term outcome has been associated with shorter telomeres. Shortened telomeres have also been reported to result from excessive food consumption and/or unhealthy nutrition...
February 21, 2018: Critical Care: the Official Journal of the Critical Care Forum
P Y Santiago, F Becquet, X Zanlonghi, J M Bosc
This study aimed to precisely map current ophthalmologic consultation in France through systematic data collection in one consultation day. Nine ophthalmologic centers participated in the survey, performing 1148 observations of patients aged from 2 to 102 years old, with a mean of 55.12years old and a male/female distribution of 43.8 %/56.2 %. In general, the patients came in either spontaneously (28.8 %) or for follow-up (59.6 %). Emergency consultations comprised 5.7 % of all cases. Comorbidities or major risk factors were found...
February 10, 2018: Journal Français D'ophtalmologie
Denis Fouque, Hubert Roth, Bernadette Darné, Louis Jean-Bouchet, Eric Daugas, Tilman B Drüeke, Thierry Hannedouche, Guillaume Jean, Gérard M London
Background: Abnormal serum phosphate, calcium and parathyroid hormone (PTH) levels in patients with chronic kidney disease (CKD) undergoing haemodialysis have been associated with poor survival. The French Phosphorus and Calcium Observatory (Photo-Graphe ® 3) aimed to estimate the percentage of CKD patients achieving the three Kidney Disease: Improving Global Outcomes (KDIGO) targets about optimal serum phosphate, calcium and PTH over a 3.5-year follow-up period. Methods: This was a prospective, multicentre, epidemiological observational study conducted with nephrologists in France, selected using a clustering approach...
February 2018: Clinical Kidney Journal
Tetsu Ohnuma, Yoshiro Hayashi, Kazuto Yamashita, John Marquess, Alan Kawarai Lefor, Masamitsu Sanui
Although a majority of patients in the intensive care unit (ICU) receive antibiotics, little is known about patterns of antibiotic use in ICUs in Japan. The objective of this study was to evaluate the pattern of antibiotic use in ICUs. A nationwide one-day cross-sectional surveillance of antibiotic use in the ICU was conducted three times between January 2011 and December 2011. All patients aged ≧16-years old were included. Data from 52 ICUs and 1148 patients were reviewed. There were 1028 prescriptions for intravenous antibiotics...
February 1, 2018: International Journal of Antimicrobial Agents
Jessica Caudwell-Hall, Ixora Kamisan Atan, Chris Brown, Rodrigo Guzman Rojas, Susanna Langer, Ka Lai Shek, Hans Peter Dietz
INTRODUCTION: Levator trauma is a risk factor for development of pelvic organ prolapse. We aimed to identify antenatal predictors for significant damage to the levator ani muscle during first vaginal delivery. MATERIALS AND METHODS: A retrospective observational study utilising data from two studies with identical inclusion criteria and assessment protocols between 2005 and 2014. 1148 primiparae with an uncomplicated singleton pregnancy were recruited and assessed with translabial ultrasound at 36 weeks antepartum and 871 (76%) returned for reassessment 3-6 months postpartum...
February 2, 2018: Acta Obstetricia et Gynecologica Scandinavica
Hanna Vihonen, Markku Kuisma, Jouni Nurmi
BACKGROUND: The current study investigates the incidence, aetiology, and outcome of hypoglycaemia of patients without diabetes in the EMS. METHODS: The study was a retrospective cohort study that utilized electronic EMS patient record system (population of one million). All patients encountered by EMS with plasma glucose ≤3.9 mmol/l from 2009 to 2015 were included in the study and hospital records were screened manually to detect possible reasons for hypoglycaemia...
February 1, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Zhibin Li, Changqin Liu, Xiulin Shi, Zheng Chen, Dongmei Wang, Long Li, Yichang Tu, Mingzhu Lin, Suhuan Liu, Shuyu Yang, Xuejun Li
Elevated serum fetuin-B is suggested to be associated with insulin resistance, but it is unknown if this association is causal. The aim of this study was to explore the potential causal relationship between fetuin-B and insulin resistance.We used Mendelian randomization analysis by incorporating information of genetic variants in FETUB and serum fetuin-B concentrations with insulin resistance in 1148 obese Chinese adults.Common genetic variants (FETUB rs4686434, rs6785067, and rs3733159) were significantly associated with serum fetuin-B concentrations but not with insulin resistance...
December 2017: Medicine (Baltimore)
Rajkumar Chinnadurai, James Ritchie, Darren Green, Philip A Kalra
Background: Non-alcoholic fatty liver disease (NAFLD) is an independent risk factor associated with cardiovascular disease (CVD) and incidence of chronic kidney disease (CKD). NAFLD is threatening to become a major public health problem in association with the metabolic syndrome. The association of NAFLD with outcomes in patients with advanced CKD has not been evaluated. In this study, the prevalence of NAFLD and its impact on cardiovascular and renal outcomes and mortality were determined in a large secondary care CKD cohort...
January 30, 2018: Nephrology, Dialysis, Transplantation
Vincent Roolvink, Veemal V Hemradj, Jan Paul Ottervanger, Arnoud Wj van 't Hof, Jan-Henk E Dambrink, At Marcel Gosselink, Elvin Kedhi, Harry Suryapranata
BACKGROUND: The association between chronic beta-blocker treatment and haemodynamics at admission in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention is not well studied. We investigated the impact of chronic beta-blocker treatment on the risk of cardiogenic shock and pre-shock at admission in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention. METHODS AND RESULTS: A total of 4907 patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention were included in the study...
January 1, 2018: European Heart Journal. Acute Cardiovascular Care
Guray Kuzu, Ozlem Keskin, Ruth Nussinov, Attila Gursoy
A revised Table 6 and Supporting Information are provided for the article by Kuzu et al. [(2016), Acta Cryst. D72, 1137-1148].
January 1, 2018: Acta Crystallographica. Section D, Structural Biology
Joanna Stańczak, Beata Biernat, Maria Racewicz, Marta Zalewska, Anna Matyjasek
In two surveys conducted in April and May 2013, a total of 1148 unfed ticks belonging to two species, Ixodes ricinus and Dermacentor reticulatus, were collected by flagging lower vegetation in 15 different localities throughout the Białowieża Primeval Forest (Podlaskie voivodship; north-eastern Poland) and in its buffer zone. In order to establish their infection rate with Rickettsia spp. individual adult ticks and pooled nymphs were tested by real-time PCR targeting the gltA gene. For the further identification of rickettsial species, positive samples were subjected for nested and semi-nested PCR targeting ompA and 16S rRNA genes, respectively, followed by sequencing analysis...
December 21, 2017: Ticks and Tick-borne Diseases
Alfredo Nuñez-Castruita, Norberto López-Serna
OBJECTIVES: To determine the prevalence of low-set ears (LSE) in a group of human foetuses, to analyse the associated anomalies, and to review the development mechanisms possibly involved. METHODS: A total of 1759 human foetuses from spontaneous abortion were evaluated. Foetuses were obtained from the Foetuses and Embryos Collection of the Embryology Department of the Faculty of Medicine of the Autonomous University of Nuevo León. The Ethics Committee gave its approval for this study (EH-230-16)...
January 2018: International Journal of Pediatric Otorhinolaryngology
Shahrzad Salmasi, Kah Seng Lee, Long Chiau Ming, Chin Fen Neoh, Mahmoud E Elrggal, Zaheer-Ud- Din Babar, Tahir Mehmood Khan, Muhammad Abdul Hadi
BACKGROUND: Globally, cancer is one of the leading causes of mortality. High treatment cost, partly owing to higher prices of anti-cancer drugs, presents a significant burden on patients and healthcare systems. The aim of the present study was to survey and compare retail prices of anti-cancer drugs between high, middle and low income countries in the South-East Asia, Western Pacific and Eastern Mediterranean regions. METHODS: Cross-sectional survey design was used for the present study...
December 28, 2017: BMC Cancer
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