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https://www.readbyqxmd.com/read/29132344/tubeless-versus-standard-percutaneous-nephrolithotomy-an-update-meta-analysis
#1
Yang Xun, Qing Wang, Henglong Hu, Yuchao Lu, Jiaqiao Zhang, Baolong Qin, Yudi Geng, Shaogang Wang
BACKGROUND: To update a previously published systematic review and meta-analysis on the efficacy and safety of tubeless percutaneous nephrolithotomy (PCNL). METHODS: A systematic literature search of EMBASE, PubMed, Web of Science, and the Cochrane Library was performed to confirm relevant studies. The scientific literature was screened in accordance with the predetermined inclusion and exclusion criteria. After quality assessment and data extraction from the eligible studies, a meta-analysis was conducted using Stata SE 12...
November 13, 2017: BMC Urology
https://www.readbyqxmd.com/read/29113317/hydroxychloroquine-and-risk-of-cancer-in-patients-with-primary-sj%C3%A3-gren-syndrome-propensity-score-matched-landmark-analysis
#2
Yao-Fan Fang, Yen-Fu Chen, Ting-Ting Chung, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Chang-Fu Kuo, Jenn-Haung Lai
Hydroxychloroquine inhibits systemic inflammation and autophagy and may thus have antineoplastic effects [1]. We investigated the effect of hydroxychloroquine on cancer risk in patients with primary Sjögren syndrome(pSS). We used the Taiwan National Health Insurance Database to compare cancer incidence between incident pSS patients with or without at least 6-month hydroxychloroquine use within a 1- or 3-year period. Propensity score matched landmark analysis was used. We included 4194 alive patients without cancer 1 year after pSS diagnosis from 2000 through 2005...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29063225/preperitoneal-surgical-approach-to-treat-vesicoureteral-anastomotic-leakage-distal-stenosis-or-reflux-after-kidney-transplantation
#3
Tom Darius, Antoine Buemi, Laurent Coubeau, Nada Kanaan, Pierre Goffette, Michel Mourad
BACKGROUND: If endourological approaches are not applicable to treat vesicoureteral anastomotic complications after kidney transplantation, the surgical gold standard in many transplant centers is pyeloureterostomy or ureteroureterostomy using the native ureter. We report an original preperitoneal technique that can be used for vesicoureteral reanastomosis in kidney transplant recipients not eligible for endourological treatment. METHODS: Between January 2011 and December 2015, 18 kidney transplant recipients underwent this new surgical procedure...
October 23, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29059503/optimization-of-substrate-analog-furin-inhibitors
#4
Teodora Ivanova, Kornelia Hardes, Stephanie Kallis, Sven O Dahms, Manuel E Than, Sebastian Künzel, Eva Böttcher-Friebertshäuser, Iris Lindberg, Guan-Sheng Jiao, Ralf Bartenschlager, Torsten Steinmetzer
The proprotein convertase furin is a potential target for drug design, especially for the inhibition of furin-dependent virus replication. All effective synthetic furin inhibitors identified thus far are multibasic compounds; the highest potency was found for our previously developed inhibitor 4-(guanidinomethyl)-phenylacetyl-Arg-Tle-Arg-4-amidinobenzylamide (MI-1148). A first study in mice revealed a narrow therapeutic range for this tetrabasic compound, while significantly reduced toxicity was observed for some tribasic analogs...
October 23, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29053404/positive-body-image-is-positively-associated-with-hedonic-emotional-and-eudaimonic-psychological-and-social-well-being-in-british-adults
#5
Viren Swami, Laura Weis, David Barron, Adrian Furnham
Studies examining associations between positive body image and well-being have used a limited array of measures of each construct. To rectify this, we asked an online sample of 1148 UK adults to complete a range of measures of positive body image (body appreciation, body image flexibility, body pride, body acceptance from others) and a multi-dimensional measure of well-being (emotional, psychological, and social). Results showed that, once the effects of age and body mass index (BMI) had been accounted for, body appreciation significantly predicted all dimensions of well-being...
October 20, 2017: Journal of Social Psychology
https://www.readbyqxmd.com/read/28944055/understanding-the-links-between-resilience-and-type-2-diabetes-self-management-a-qualitative-study-in-south-australia
#6
A L Wilson, D McNaughton, S B Meyer, P R Ward
BACKGROUND: Research conducted by Ward, Muller, Tsourtos, et al. (Soc Sci Med 72(7):1140-1148, 2011) has led to the development of the psycho-social interactive model of resilience, which reveals the interaction between individual resilience factors (i.e. coping, confidence and self esteem) and external resilience environments (i.e. employment, supportive family environments and health promoting policies) in facilitating the development of resilience. This present study explored the utility of this model of resilience for understanding how people self-manage type-2 diabetes...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28933974/the-influence-of-unilateral-oophorectomy-on-the-age-of-menopause
#7
M Rosendahl, M K Simonsen, J J Kjer
OBJECTIVE: To determine the age of menopause after premenopausal unilateral oophorectomy (UO) and to establish whether UO at a young age leads to menopause at a younger age than if UO occurs at an older age. METHODS: A cohort of 28 731 women, of whom 17 781 (62%) were menopausal, was investigated. Information on menopause was obtained from self-reported questionnaires. Surgical data were obtained from the National Patient Register to avoid recollection bias...
September 21, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28923008/an-eleven-year-retrospective-hospital-based-study-of-epidemiological-data-regarding-human-strongyloidiasis-in-northeast-thailand
#8
Thidarat K Prasongdee, Pokkamol Laoraksawong, Wanida Kanarkard, Ratthaphol Kraiklang, Kraisit Sathapornworachai, Sureeporn Naonongwai, Porntip Laummaunwai, Oranuch Sanpool, Pewpan M Intapan, Wanchai Maleewong
BACKGROUND: Human strongyloidiasis is a chronic and persistent gastrointestinal disease caused by infection with soil-transmitted helminths of the genus Strongyloides. The aim of this research was to obtain diagnostic prevalence regarding strongyloidiasis in northeast Thailand through a hospital-based study. METHODS: Patients' demographic data and the results of stool examinations conducted using the formalin ethyl acetate concentration technique were collected from the parasitology laboratory records at Srinagarind Hospital in Khon Kaen, Thailand...
September 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28917538/identification-of-ibv-qx-vaccine-markers-should-vaccine-acceptance-by-authorities-require-similar-identifications-for-all-live-ibv-vaccines
#9
Valeria Listorti, Andrea Laconi, Elena Catelli, Mattia Cecchinato, Caterina Lupini, Clive J Naylor
IBV genotype QX causes sufficient disease in Europe for several commercial companies to have started developing live attenuated vaccines. Here, one of those vaccines (L1148) was fully consensus sequenced alongside its progenitor field strain (1148-A) to determine vaccine markers, thereby enabling detection on farms. Twenty-eight single nucleotide substitutions were associated with the 1148-A attenuation, of which any combination can identify vaccine L1148 in the field. Sixteen substitutions resulted in amino acid coding changes of which half were in spike...
September 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28890353/identifying-principles-for-effective-messages-about-chemicals-in-cigarette-smoke
#10
Seth M Noar, Dannielle E Kelley, Marcella H Boynton, Jennifer C Morgan, Marissa G Hall, Jennifer R Mendel, Kurt M Ribisl, Noel T Brewer
US law requires the Food and Drug Administration (FDA) to disclose information on harmful and potentially harmful chemicals in cigarette smoke (i.e., constituents) to the public. To inform this effort, we sought to identify principles for creating constituent messages that effectively discourage smoking. Participants were an online convenience sample of 1148 US smokers ages 18+. We developed a library of 76 messages about constituents only and constituents plus contextualizing information (i.e., toxic products that also contain the chemical, health effects, or both)...
September 7, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28853212/tissue-glycomics-distinguish-tumour-sites-in-women-with-advanced-serous-adenocarcinoma
#11
Merrina Anugraham, Francis Jacob, Arun V Everest-Dass, Andreas Schoetzau, Sheri Nixdorf, Neville F Hacker, Daniel Fink, Viola Heinzelmann-Schwarz, Nicolle H Packer
In the era of precision medicine, the tailoring of cancer treatment is increasingly important as we transition from organ-based diagnosis towards a more comprehensive and patient-centric molecular diagnosis. This is particularly the case for high-grade serous adenocarcinomas of the ovary and peritoneum, which are commonly diagnosed at an advanced stage, and collectively treated and managed similarly. We characterized the N- and O-glycome of serous ovarian (OC) and peritoneal cancer (PC) tissues using PGC-LC-ESI-IT-MS/MS profiling and validated the discriminatory glycans and their corresponding glyco-gene expression levels using cell lines and transcriptomic data from 232 patients...
November 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28834070/patient-navigation-for-patients-frequently-visiting-the-emergency-department-a-randomized-controlled-trial
#12
David Seaberg, Stanton Elseroad, Michael Dumas, Sudave Mendiratta, Jessica Whittle, Cheryl Hyatte, Jan Keys
BACKGROUND: Emergency department (ED) superutilizers (patients with five or more visits/year) comprise only 5% of the patients seen yet comprise 25% of total ED visits. Although the reasons for this are multifactorial, the cost to the patient and the community is exceedingly high. The cost is not just monetary; care of these patients is inappropriately fragmented and their presence in the ED may contribute to overcrowding affecting the community's emergency readiness. Previous studies using staff trained to help patients navigate their care options have had conflicting results...
August 21, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28793003/complete-axillary-dissection-without-drainage-for-the-surgical-treatment-of-breast-cancer-a-randomized-clinical-trial
#13
Ruffo Freitas-Junior, Luís Fernando Jubé Ribeiro, Marise Amaral Rebouças Moreira, Geraldo Silva Queiroz, Maurício Duarte Esperidião, Marco Aurélio Costa Silva, Rubens José Pereira, Rossana Araújo Catão Zampronha, Rosemar Macedo Sousa Rahal, Leonardo Ribeiro Soares, Danielle Laperche Dos Santos, Maria Virginia Thomazini, Cassiana Ferreira Silva de Faria, Régis Resende Paulinelli
OBJECTIVE: This randomized clinical trial evaluated the possibility of not draining the axilla following axillary dissection. METHODS: The study included 240 breast cancer patients who underwent axillary dissection as part of conservative treatment. The patients were divided into two groups depending on whether or not they were subjected to axillary drainage. ClinicalTrials.gov: NCT01267552. RESULTS: The median volume of fluid aspirated was significantly lower in the axillary drainage group (0...
July 2017: Clinics
https://www.readbyqxmd.com/read/28783821/maintenance-of-certification-and-texas-sb-1148-a-threat-to-professional-self-regulation
#14
David H Johnson
No abstract text is available yet for this article.
August 22, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28731372/exploring-the-effect-of-vitamin-d3-supplementation-on-the-anti-ebv-antibody-response-in-relapsing-remitting-multiple-sclerosis
#15
Linda Rolf, Anne-Hilde Muris, Amandine Mathias, Renaud Du Pasquier, Inga Koneczny, Giulio Disanto, Jens Kuhle, Sreeram Ramagopalan, Jan Damoiseaux, Joost Smolders, Raymond Hupperts
BACKGROUND: Epstein-Barr virus (EBV) infection and vitamin D insufficiency are potentially interacting risk factors for multiple sclerosis (MS). OBJECTIVES: To investigate the effect of high-dose vitamin D3 supplements on antibody levels against the EBV nuclear antigen-1 (EBNA-1) in patients with relapsing-remitting multiple sclerosis (RRMS) and to explore any underlying mechanism affecting anti-EBNA-1 antibody levels. METHODS: This study utilized blood samples from a randomized controlled trial in RRMS patients receiving either vitamin D3 (14,000 IU/day; n = 30) or placebo ( n = 23) over 48 weeks...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28722669/hydroxychloroquine-and-risk-of-cancer-in-patients-with-primary-sj%C3%A3-gren-syndrome-propensity-score-matched-landmark-analysis
#16
Yao-Fan Fang, Yen-Fu Chen, Ting-Ting Chung, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Chang-Fu Kuo, Jenn-Haung Lai
Hydroxychloroquine inhibits systemic inflammation and autophagy and may thus have antineoplastic effects [1]. We investigated the effect of hydroxychloroquine on cancer risk in patients with primary Sjögren syndrome(pSS). We used the Taiwan National Health Insurance Database to compare cancer incidence between incident pSS patients with or without at least 6-month hydroxychloroquine use within a 1- or 3-year period. Propensity score matched landmark analysis was used. We included 4194 alive patients without cancer 1 year after pSS diagnosis from 2000 through 2005...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28714331/-hand-hygiene-technique-assessment-using-electronic-equipment-in-26-hungarian-healthcare-institutions
#17
Ákos Lehotsky, Júlia Morvai, László Szilágyi, Száva Bánsághi, Alíz Benkó, Tamás Haidegger
INTRODUCTION: Hand hygiene is probably the most effective tool of nosocomial infection prevention, however, proper feedback and control is needed to develop the individual hand hygiene practice. AIM: Assessing the efficiency of modern education tools, and digital demonstration and verification equipment during their wide-range deployment. METHOD: 1269 healthcare workers took part in a training organized by our team. The training included the assessment of the participants' hand hygiene technique to identify the most often missed areas...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28708490/effect-of-season-and-age-on-indian-red-jungle-fowl-gallus-gallus-murghi-semen-characteristics-a-4-year-retrospective-study
#18
B A Rakha, M S Ansari, S Akhter, E Blesbois
The reproductive potential of the adult males is expected to vary with age/season and largely differ not only in closely related avian species but even in subspecies, breeds and/or strains of the same species. Thus, it is pre-requisite to have knowledge of seminal parameters to achieve maximum production potential of at-risk species for ex situ in vitro conservation programs. A 4-year study was designed to evaluate the effect of age and season (spring, summer, autumn and winter) on semen characteristics of Indian red jungle fowl (Gallus gallus murghi) in a retrospective manner...
May 24, 2017: Theriogenology
https://www.readbyqxmd.com/read/28697021/injuries-sustained-during-contact-with-law-enforcement-an-analysis-from-us-trauma-centers
#19
Morgan Schellenberg, Kenji Inaba, Jayun Cho, James M Tatum, Galinos Barmparas, Aaron Strumwasser, Daniel Grabo, Cynthia Bir, Alexander Eastman, Demetrios Demetriades
BACKGROUND: Injuries sustained by civilians from interaction with police are a polarizing contemporary sociopolitical issue. Few comprehensive studies have been published using national hospital-based data. The aim of this study was to examine the epidemiology of these injuries to better understand this mechanism of injury. METHODS: Patients entered into the NTDB (01/2007 - 12/2012) with E-codes E970.0-E976.0 (ICD-9-CM), identifying injuries associated with law enforcement in the course of legal action, were enrolled...
July 8, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28691436/viral-kinetics-in-untreated-versus-treated-acute-hiv-infection-in-prospective-cohort-studies-in-thailand
#20
Jintanat Ananworanich, Leigh Anne Eller, Suteeraporn Pinyakorn, Eugene Kroon, Somchai Sriplenchan, James Lk Fletcher, Duanghathai Suttichom, Christopher Bryant, Rapee Trichavaroj, Peter Dawson, Nelson Michael, Nittaya Phanuphak, Merlin L Robb
INTRODUCTION: The extent of viral replication during acute HIV infection (AHI) influences HIV disease progression. However, information comparing viral load (VL) kinetics with and without antiretroviral therapy (ART) in AHI is limited. The knowledge gained could inform preventive strategies aimed at reducing VL during AHI and therapeutic strategies to alter the viral kinetics that may enhance the likelihood of achieving HIV remission. METHODS: The analysis utilized VL data captured during the first year of HIV infection from two studies in Thailand: the RV217 study (untreated AHI, 30 participants and 412 visits) and the RV254 study (treated AHI, 235 participants and 2803 visits)...
June 26, 2017: Journal of the International AIDS Society
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