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Sonia Duarte de Azevedo Bittencourt, Rosa Maria Soares Madeira Domingues, Lenice Gnocchi da Costa Reis, Márcia Melo Ramos, Maria do Carmo Leal
BACKGROUND: In Brazil, hospital childbirth care is available to all, but differences in access and quality of care result in inequalities of maternal health. The objective of this study is to assess the infrastructure and staffing of publicly financed labor and birth care in Brazil and its adequacy according to clinical and obstetric conditions potentially associated with obstetric emergencies. METHODS: Nationwide cross-sectional hospital-based study "Birth in Brazil: national survey into labor and birth" conducted in 2011-2012...
October 17, 2016: Reproductive Health
Julia R Van Liew, Rebecca L Brock, Alan J Christensen, Lucy Hynds Karnell, Nitin A Pagedar, Gerry F Funk
BACKGROUND: Weight loss and depressive symptoms are critical head and neck cancer outcomes, yet their relation over the illness course is unclear. METHODS: Associations between self-reported depressive symptoms and objective weight loss across the year after head and neck cancer diagnosis were examined using growth curve modeling techniques (n = 564). RESULTS: A reciprocal covariation pattern emerged-changes in depressive symptoms over time were associated with same-month changes in weight loss (t [1148] = 2...
October 5, 2016: Head & Neck
Takeshi Takahara, Go Wakabayashi, Hiroyuki Konno, Mitsukazu Gotoh, Hiroki Yamaue, Katsuhiko Yanaga, Jirou Fujimoto, Hironori Kaneko, Michiaki Unno, Itaru Endo, Yasuyuki Seto, Hiroaki Miyata, Masaru Miyazaki, Masakazu Yamamoto
BACKGROUND: The National Clinical Database (NCD) in Japan is a nationwide registry that collects the data of more than 1,200,000 surgical cases annually from over 3,500 hospitals. Based on the NCD data, this study compared the perioperative outcomes of major laparoscopic liver resection (LLR) with those of major open liver resection (OLR) using the propensity score matching method. METHODS: We collected data on 15,191 major hepatectomy cases (929 major LLR cases and 14,262 major OLR cases), and investigated the short-term outcomes in well-matched groups...
September 29, 2016: Journal of Hepato-biliary-pancreatic Sciences
A Stengel, W Kern, T Haferlach, M Meggendorfer, A Fasan, C Haferlach
Alterations in TP53 have been described in many cancer types including hematological neoplasms. We aimed at comparing TP53 mutations (mut) and deletions (del) in a large cohort of patients with hematological malignancies (n=3307), including AML (n=858), MDS (n=943), ALL (n=358), CLL (n=1148). Overall, alterations in TP53 were detected in 332/3307 cases (10%). The highest frequency was observed in ALL (total: 19%; mut+del: 6%; mut only: 8%; del only: 5%) and AML (total: 13%; mut+del: 5%; mut only: 7%; del only: 1%), whereas TP53 alterations occurred less frequently in CLL (total: 8%) and MDS (total: 7%)...
October 14, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Paul M Palevsky, Jane H Zhang, Stephen L Seliger, Nicholas Emanuele, Linda F Fried
BACKGROUND AND OBJECTIVES: The benefit of dual blockade of the renin-angiotensin system is limited by adverse effects. We performed a secondary analysis of the Veterans Affairs Nephropathy in Diabetes (VA NEPHRON-D) Study to describe the effect of increased intensity of renin-angiotensin system blockade on the incidence, risk factors, and outcomes of AKI. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In the VA NEPHRON-D Study, we randomized 1148 veterans receiving outpatient care with type 2 diabetes mellitus, eGFR of between 30 and 89...
September 27, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Luciane R Piccolo, Emily C Merz, Xiaofu He, Elizabeth R Sowell, Kimberly G Noble
Recent findings indicate robust associations between socioeconomic status (SES) and brain structure in children, raising questions about the ways in which SES may modify structural brain development. In general, cortical thickness and surface area develop in nonlinear patterns across childhood and adolescence, with developmental patterns varying to some degree by cortical region. Here, we examined whether age-related nonlinear changes in cortical thickness and surface area varied by SES, as indexed by family income and parental education...
2016: PloS One
Pasqualino Sirignano, Francesco Speziale, Laura Capoccia, Danilo Menna, Wassim Mansour, Nunzio Montelione, Francesco Setacci, Giuseppe Galzerano, Carlo Setacci
BACKGROUND: To evaluate the impact of iliac artery's diameters, tortuosity, and peripheral vascular patency on outcome of elective endovascular repair (EVAR) of abdominal aortic aneurysms (AAA) in 2 high volume vascular centers' experience. METHODS: A retrospective study was conducted on a prospectively collected database between 2010 and 2012. Anatomical features at pre-operative computed tomography (CTA) considered as potentially influencing outcomes were: iliac diameters, tortuosity (expressed as a ratio), and calcifications, bilateral internal iliac artery (IIA) patency, and presence of Trans-Atlantic Inter-Societies Consensus (TASC) II C/D femoro-popliteal occlusive disease (PAD)...
September 16, 2016: Journal of Cardiovascular Surgery
F V Bauermann, S M Falkenberg, J F Ridpath
The ability of ruminant pestivirus including bovine viral diarrhoea virus (BVDV) and the related emerging pestivirus, HoBi-like virus, to establish persistent infection (PI) following foetal infection is central to keeping these viruses in circulation. Non-PI dams carrying BVDV PI calves develop high levels of immunity due constantly viral exposure. A study to determine whether the immunity developed following the generation of a BVDV PI is enough to prevent HoBi-like virus infection of a subsequent foetus was performed...
September 11, 2016: Transboundary and Emerging Diseases
Guang-Shing Cheng, Zach J Stednick, David K Madtes, Michael Boeckh, George B McDonald, Steven A Pergam
Historically, diagnosis of enigmatic pulmonary disease after hematopoietic cell transplantation (HCT) required lung biopsy, but recent advancements in diagnosis and therapy for respiratory infections have changed how clinicians approach pulmonary abnormalities. We examined temporal trends in the use of lung biopsy after HCT. We retrospectively reviewed patients who underwent their first allogeneic HCT at the Fred Hutchinson Cancer Research Center between the years 1993 to 1997, 2003 to 2007, and 2013 to 2015 and subsequently underwent surgical lung biopsy for any reason...
August 31, 2016: Biology of Blood and Marrow Transplantation
Nils Hansen-Algenstaedt, Mun Keong Kwan, Petra Algenstaedt, Chee Kidd Chiu, Lennart Viezens, Teik Seng Chan, Chee Kean Lee, Jasmin Wellbrock, Chris Yin Wei Chan, Christian Schaefer
STUDY DESIGN: Prospective Propensity Score-Matched Study OBJECTIVE.: To compare the outcomes of minimal invasive surgery (MIS) and conventional open surgery for spinal metastasis patients. SUMMARY OF BACKGROUND DATA: There is lack of knowledge on whether minimally invasive surgery is comparable to conventional open surgery in treating spinal metastasis patients. METHODS: Spinal metastasis patients requiring surgeries from January 2008 to December 2010 in two spine centers were recruited...
August 31, 2016: Spine
Aaron Wong, James McKelvie, Carol Slight, Joanne Sims
PURPOSE: To investigate the patterns of uveitis at a tertiary referral center in New Zealand. METHODS: Retrospective data were collected for 1260 patients presenting to uveitis clinics in Auckland, New Zealand, between January 2008 and April 2014. Demographics, disease characteristics, and uveitis subtype were analyzed for all patients. RESULTS: Among 1148 patients, 70.3% had anterior uveitis. The most common diagnosis causing anterior uveitis was HLA B27-associated disease...
August 18, 2016: Ocular Immunology and Inflammation
Qian Cui, Fu-Tuo Feng, Miao Xu, Wen-Sheng Liu, You-Yuan Yao, Shang-Hang Xie, Xi-Zhao Li, Zu-Lu Ye, Qi-Sheng Feng, Li-Zhen Chen, Jin-Xin Bei, Lin Feng, Qi-Hong Huang, Wei-Hua Jia, Su-Mei Cao, Ellen T Chang, Weimin Ye, Hans-Olov Adami, Yi-Xin Zeng
Genetic susceptibility and Epstein-Barr virus (EBV) infection are important etiological factors in nasopharyngeal carcinoma (NPC). In this study, in southern China, where NPC is endemic, a single nucleotide polymorphism (SNP) in the EBV-encoded RPMS1 gene (locus 155391: G > A [G155391A]) and seven host SNPs (rs1412829, rs28421666, rs2860580, rs2894207, rs31489, rs6774494, and rs9510787) were confirmed to be significantly associated with NPC risk in 50 NPC cases versus 54 hospital-based controls with throat washing specimens and 1925 NPC cases versus 1947 hospital-based controls with buffy coat samples, respectively...
August 9, 2016: Oncotarget
Sara Burke, Vicki Black, Fernando Sánchez-Vizcaíno, Alan Radford, Angie Hibbert, Séverine Tasker
OBJECTIVES: The objective was to use electronic health records to describe the use of cefovecin (Convenia; Zoetis UK), a third-generation long-acting injectable antimicrobial, in a UK population of cats attending first-opinion practices, and to compare the use of Convenia to the licensed uses described on the UK Convenia datasheet. METHODS: Data were obtained as an Excel database from the Small Animal Veterinary Surveillance Network for all feline consultations containing the word Convenia and/or cefovecin from 1 September 2012 to 23 September 2013 inclusive...
August 9, 2016: Journal of Feline Medicine and Surgery
K Khunti, C L Gillies, H Dallosso, E M Brady, L J Gray, G Kilgallen, A Willis, A Zafar, M J Davies
AIMS: To assess the opportunistic use in primary care of a computer risk score versus a self-assessment risk score for undiagnosed type 2 diabetes. METHODS: We conducted a randomised controlled trial in 11 primary care practices in the UK. 577 patients aged 40-75years with no current diagnosis of type 2 diabetes were recruited to a computer based risk score (Leicester Practice Computer Risk Score (LPCRS)) or a patient self-assessment score (Leicester Self-Assessment Score (LSAS))...
August 2016: Diabetes Research and Clinical Practice
Tina Roche, Natasha Jennings, Stuart Clifford, Jane O'connell, Matthew Lutze, Edward Gosden, N Fionna Hadden, Glenn Gardner
Risk stratification tools for patients presenting to rural EDs with undifferentiated chest pain enable early definitive treatment in high-risk patients. This systematic review compares the most commonly used risk stratification tools used to predict the risk of major adverse cardiac event (MACE) for patients presenting to rural EDs with chest pain. A comprehensive search of MEDLINE and Embase for studies published between January 2011 and January 2015 was undertaken. Study quality was assessed using QUADAS-2 criteria and the PRISMA guidelines...
October 2016: Emergency Medicine Australasia: EMA
Roxanne P Kerani, Joshua T Herbeck, Susan E Buskin, Julia C Dombrowksi, Amy Bennett, Elizabeth Barash, Lindley A Barbee, Matthew R Golden
Little is known about the frequency of ongoing HIV transmission within U.S. African immigrant communities. We used HIV surveillance and partner services data to describe African-born persons newly reported with HIV infection in King County (KC), WA from 1/1/2010 to 12/31/2013. We performed phylogenetic clustering analysis of HIV-1 pol to identify putative transmission events within this population. From 2010 to 2013, 1148 KC adults were reported with HIV, including 102 (9 %) born in Africa. Forty-one African-born cases were interviewed and reported diagnosis after arrival in the U...
July 9, 2016: Journal of Immigrant and Minority Health
Andrew Finney, Emma Healey, Joanne L Jordan, Sarah Ryan, Krysia S Dziedzic
BACKGROUND: The National Institute for Health and Care Excellence's Osteoarthritis (OA) guidelines recommended that future research should consider the benefits of combination therapies in people with OA across multiple joint sites. However, the clinical effectiveness of such approaches to OA management is unknown. This systematic review therefore aimed to identify the clinical and cost effectiveness of multidisciplinary approaches targeting multiple joint sites for OA in primary care...
2016: BMC Musculoskeletal Disorders
Ulf K Radunski, Gunnar K Lund, Dennis Säring, Sebastian Bohnen, Christian Stehning, Bernhard Schnackenburg, Maxim Avanesov, Enver Tahir, Gerhard Adam, Stefan Blankenberg, Kai Muellerleile
INTRODUCTION: This study evaluated the ability of T1 and T2 mapping cardiovascular magnetic resonance (CMR) to detect myocardial injury in apparently normal myocardium of patients with myocarditis. MATERIALS AND METHODS: We included 20 patients with "infarct-like" acute myocarditis who had typical focal myocardial lesions on late gadolinium enhancement (LGE) images as well as 20 healthy controls. The CMR protocol consisted of a standard myocarditis protocol which was combined with T1 (modified Look-Locker inversion recovery (MOLLI) with a 3(3)5 scheme and T2 mapping (hybrid gradient- and spin-echo multi-echo sequence, GraSE)...
July 7, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Dvir Netanely, Ayelet Avraham, Adit Ben-Baruch, Ella Evron, Ron Shamir
BACKGROUND: Breast cancer is a heterogeneous disease comprising several biologically different types, exhibiting diverse responses to treatment. In the past years, gene expression profiling has led to definition of several "intrinsic subtypes" of breast cancer (basal-like, HER2-enriched, luminal-A, luminal-B and normal-like), and microarray based predictors such as PAM50 have been developed. Despite their advantage over traditional histopathological classification, precise identification of breast cancer subtypes, especially within the largest and highly variable luminal-A class, remains a challenge...
2016: Breast Cancer Research: BCR
Erika Frischknecht Christensen, Thomas Mulvad Larsen, Flemming Bøgh Jensen, Mette Dahl Bendtsen, Poul Anders Hansen, Søren Paaske Johnsen, Christian Fynbo Christiansen
OBJECTIVE: Knowledge about patients after calling for an ambulance is limited to subgroups, such as patients with cardiac arrest, myocardial infarction, trauma and stroke, while population-based studies including all diagnoses are few. We examined the diagnostic pattern and mortality among all patients brought to hospital by ambulance after emergency calls. DESIGN: Registry-based cohort study. SETTING AND PARTICIPANTS: We included patients brought to hospital in an ambulance dispatched after emergency calls during 2007-2014 in the North Denmark Region (580 000 inhabitants)...
2016: BMJ Open
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