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https://www.readbyqxmd.com/read/28938005/recombinant-vaccines-of-a-cd4-t-cell-epitope-promote-efficient-control-of-paracoccidioides-brasiliensis-burden-by-restraining-primary-organ-infection
#1
Rodrigo Assunção Holanda, Julián Esteban Muñoz, Lucas Santos Dias, Leandro Buffoni Roque Silva, Julliana Ribeiro Alves Santos, Sthefany Pagliari, Érica Leandro Marciano Vieira, Tatiane Alves Paixão, Carlos Pelleschi Taborda, Daniel Assis Santos, Oscar Bruña-Romero
Paracoccidioidomycosis (PCM) is an infectious disease endemic to South America, caused by the thermally dimorphic fungi Paracoccidioides. Currently, there is no effective human vaccine that can be used in prophylactic or therapeutic regimes. We tested the hypothesis that the immunogenicity of the immunodominant CD4+ T-cell epitope (P10) of Paracoccidioides brasiliensis gp43 antigen might be significantly enhanced by using a hepatitis B virus-derived particle (VLP) as an antigen carrier. This chimera was administered to mice as a (His)6-purified protein (rPbT) or a replication-deficient human type 5 adenoviral vector (rAdPbT) in an immunoprophylaxis assay...
September 22, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28933800/prevalence-and-morphometric-analysis-of-idiopathic-osteosclerosis-in-a-chilean-population
#2
Ramón Fuentes, Alain Arias, Nicolás Astete, Constanza Farfán, Ivonne Garay, Fernando Dias
The aim of this study was to analyse the prevalence and morphometric parameters of idiopathic osteosclerosis (IO) in a Chilean population. IO is an intraosseous growth of compact, benign, unilocular, non-expandable bone that is referred to as an anatomical variation. A cross-sectional study was performed using 1000 digital panoramic radiographs of adults in which data on the location (maxillary/mandibular, right/left hemiarcades), shape, position to the dental apex, and the prevalence of IOs were observed in relation to gender and age...
September 21, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28933317/elstera-cyanobacteriorum-sp-nov-a-novel-bacterium-isolated-from-cyanobacterial-aggregates-in-a-eutrophic-lake
#3
Haiyuan Cai, Yonghui Zeng, Yanan Wang, Helong Jiang
A bacterial strain, TH019T, was isolated from cyanobacterial aggregates in a eutrophic lake, Taihu Lake, China. Cells were observed to be slightly curved rod-shaped and stained Gram-negative. Optimal growth was obtained at pH 7.0 (range, 5.0-9.0) and 28 °C (range, 20-37 °C) in R2A broth. The cells were found to be positive for oxidase and catalase activities, nitrate reduction and denitrification. The major respiratory quinone was ubiquinone Q-10. The major fatty acids were identified as C18 : 1 ω6c/C18 : 1 ω7c and C18 : 1 2OH...
September 21, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28932267/clinical-performance-of-an-infliximab-rapid-quantification-assay
#4
Fernando Magro, Joana Afonso, Susana Lopes, Rosa Coelho, Raquel Gonçalves, Paulo Caldeira, Paula Lago, Helena Tavares de Sousa, Jaime Ramos, Ana Rita Gonçalves, Paula Ministro, Isadora Rosa, Tânia Meira, Patrícia Andrade, João-Bruno Soares, Diana Carvalho, Paula Sousa, Ana Isabel Vieira, Joanne Lopes, Cláudia Camila Dias, Karel Geboes, Fátima Carneiro
BACKGROUND: Therapeutic drug monitoring (TDM)-based algorithms can be used to guide infliximab (IFX) adjustments in inflammatory bowel disease (IBD) patients. This study aimed to explore a rapid IFX-quantification test from a clinical perspective. METHODS: This manuscript describes a prospective cohort study involving 110 ulcerative colitis (UC) patients on the maintenance phase of IFX. IFX trough levels were quantified using a rapid quantification assay and a commonly-used reference kit...
September 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28930498/molecular-and-morphological-characterization-of-a-brazilian-lineage-of-plasmodium-novyella-unalis-in-turdus-spp-passeriformes-of-the-atlantic-forest-with-remarks-on-new-hosts-and-high-genetic-variation
#5
Raquel Tostes, Roberto Júnio Pedroso Dias, Luísa de Oliveira, Marcus Vinicius Xavier Senra, Carlos Luiz Massard, Marta D'Agosto
Plasmodium spp. are haemosporidian protozoans that alternate their live cycles between bloodsucking Culicidae dipterans and vertebrate hosts (mammals, reptiles and birds). In birds, these parasites are the causative agents of the so called avian malaria, a disease associated with considerable declines and extinctions in the avifauna in different geographical regions. In this work, we applied a multidisciplinary approach, light microscopy and cytochrome oxidase b (cyt b) gene sequence analysis for characterization of Plasmodium found in association with wild birds of the genus Turdus, collected in Atlantic forest fragments of southeastern Brazil...
September 20, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28928009/oropharyngeal-epignathus-with-partial-facial-duplication-report-of-a-rare-case
#6
M Herath, B S M S Siriwardena, R D Jayasinghe, D K Dias
Foetal oral teratoma or epignathus is a rare benign condition that originates in the oropharyngeal region. The term 'teratoma' refers to a mass composed of poorly organized tissues derived from each of the three germ layers. Epignathus may occur when one twin ceases development during gestation and becomes vestigial to the fully formed dominant twin. The reported incidence of epignathus is approximately 1:35,000 to 1:200,000 live births. A unique case of partial facial duplication with gross histological and radiological evidence of partial duplication of the facial elements and organs is presented herein...
September 16, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28927856/migration-flow-and-its-impact-on-tuberculosis-notification-in-portugal
#7
Ana Dias, Rita Gaio, Pedro Sousa, Marta Gomes, Olena Oliveira, Raquel Duarte
INTRODUCTION: Tuberculosis notification in Portugal has decreased in the last few years. As a consequence of the economic crisis, emigration has increased and immigration has decreased. Immigrants are a risk group for tuberculosis. Most emigrants are 20-44 years old and belong to the age group most affected by tuberculosis. OBJECTIVE: To describe the decrease in tuberculosis notification in Portugal over the last years from a demographical point of view. METHODS: Mathematical analysis was performed to quantify the effect of the migration movements (separately and simultaneously) on tuberculosis notification in Portugal from 2008 to 2014...
September 16, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28926981/antibiofilm-activity-and-mechanism-of-action-of-the-disinfectant-chloramine-t-on-candida-spp-and-its-toxicity-against-human-cells
#8
Gabriela Lacet Silva Ferreira, Pedro Luiz Rosalen, Larissa Rangel Peixoto, Ana Luiza Alves de Lima Pérez, Fabíola Galbiatti de Carvalho Carlo, Lúcio Roberto Cançado Castellano, Jefferson Muniz de Lima, Irlan Almeida Freires, Edeltrudes de Oliveira Lima, Ricardo Dias de Castro
We evaluated the antifungal and anti-biofilm activity, mechanism of action and cytotoxicity of chloramine T trihydrate (CAT) against Candida spp. The Minimum Inhibitory and Fungicidal Concentrations (MIC/MFC) of CAT were determined. Changes in CAT-treated C. albicans growth kinetics and micromorphology were evaluated, as well as the mechanism of action, and its effects on biofilm. Cytotoxicity was assessed by the hemolysis method. The data were analyzed by inferential statistics (p ≤ 0.05). CAT showed antifungal activity against all strains, with MIC values ranging between 1...
September 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28926618/teneurin-2-presence-in-rat-and-human-odontoblasts
#9
K R Torres-da-Silva, G W L Tessarin, C A Dias, I Z Guiati, E Ervolino, A Gonçalves, I M Beneti, D A Lovejoy, C A Casatti
Teneurins are transmembrane proteins consisting of four paralogues (Ten-1-4), notably expressed in the central nervous system during development. All teneurins contain a bioactive peptide in their carboxyl terminal named teneurin C-terminal associated peptide (TCAP). The present study analyzed the detailed distribution of teneurin-2-like immunoreactive (Ten-2-LI) cells in developing and mature rat molar teeth, as well as in mature human dental pulps. Ten-2 and TCAP-2 genic expressions were also evaluated in rat and human dental pulps...
2017: PloS One
https://www.readbyqxmd.com/read/28924340/hypotony-management-through-transconjunctival-scleral-flap-resuturing-analysis-of-surgical-outcomes-and-success-predictors
#10
Ana Luiza B Scoralick, Izabela Almeida, Michele Ushida, Diego T Dias, Syril Dorairaj, Tiago S Prata, Fábio N Kanadani
AIM: To investigate surgical outcomes and success predictors of transconjunctival scleral flap resuturing for the management of hypotony due to overfiltration following trabeculectomy with mitomycin C. MATERIALS AND METHODS: Noncomparative, retrospective, interventional case series in which all glaucoma patients from two glaucoma services undergoing transconjunctival scleral flap resuturing between May 2012 and July 2016 were enrolled. Included eyes had to have hypotony [intraocular pressure (IOP) < 6 mm Hg] and/or hypotony maculopathy caused by excessive filtration following trabeculectomy...
May 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/28921800/initial-testing-stage-1-of-m6620-formerly-vx-970-a-novel-atr-inhibitor-alone-and-combined-with-cisplatin-and-melphalan-by-the-pediatric-preclinical-testing-program
#11
Raushan T Kurmasheva, Dias Kurmashev, C Patrick Reynolds, Min Kang, Jianwrong Wu, Peter J Houghton, Malcolm A Smith
BACKGROUND: M6620 is a novel inhibitor of the DNA damage repair enzyme ATR, and has potentiated the activity of cisplatin and irinotecan in non-small cell lung cancer and colon cancer xenografts, respectively. PROCEDURES: M6620 was tested in vitro at concentrations ranging from 1.0 nM to 10.0 μM and at 75 nM in combination with cisplatin or melphalan. M6620 was tested against 24 solid tumor xenografts alone and in combination with cisplatin. Cisplatin was administered intraperitoneally on days 1 and 8 at a dose of 5 mg/kg...
September 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28917371/cannabinoids-for-spasticity-due-to-multiple-sclerosis-or-paraplegia-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#12
REVIEW
Victoria P da Rovare, Gabriel P A Magalhães, Guilherme D A Jardini, Matheus L Beraldo, Mariel O Gameiro, Arnav Agarwal, Gustavo José Luvizutto, Lucas Paula-Ramos, Samira Esteves Afonso Camargo, Luciane Dias de Oliveira, Rodrigo Bazan, Regina El Dib
OBJECTIVES: Spasticity remains highly prevalent in patients with spinal cord injury and multiple sclerosis. To summarize the effects of cannabinoids compared with usual care, placebo for spasticity due to multiple sclerosis (MS) or paraplegia. METHODS: Searches of MEDLINE, EMBASE, CENTRAL and LILACS to March 2017 were performed to identify randomized controlled trials. The primary outcomes were spasticity and spasm frequency. The criteria were any patient with MS and spasticity affecting upper or lower limbs or both, and that had a confirmed diagnosis of MS based on validated criteria, or however defined by the authors of the included studies...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28916037/electrochemical-aptasensor-for-human-osteopontin-detection-using-a-dna-aptamer-selected-by-selex
#13
Sofia G Meirinho, Luís G Dias, António M Peres, Lígia R Rodrigues
A DNA aptamer with affinity and specificity for human osteopontin (OPN), a potential breast cancer biomarker, was selected using the SELEX process, considering its homology rate and the stability of its secondary structures. This aptamer exhibited a satisfactory affinity towards OPN, showing dissociation constants lower than 2.5 nM. It was further used to develop a simple, label-free electrochemical aptasensor against OPN. The aptasensor showed good sensitivity towards OPN in standard solutions, being the square wave voltammetry (SWV), compared to the cyclic voltammetry, the most sensitive technique with detection and quantification limits of 1...
September 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28914629/association-between-ambulatory-blood-pressure-values-and-central-aortic-pressure-in-a-large-population-of-normotensive-and-hypertensive-patients
#14
Ana Rouxinol-Dias, Sara Araújo, José A Silva, Loide Barbosa, Jorge Polónia
OBJECTIVE: Our aim was to examine the association of ambulatory blood pressure monitoring (ABPM) and central blood pressure (CBP) data in a large set of normotensive and hypertensive patients and its relation with pulse wave velocity (PWV). PATIENTS AND METHODS: This cross-sectional study was carried out in a single centre and included 2864 individuals who carried out an ABPM, measurement of CBP from the aortic waveform (SphygmoCor) and carotid-femoral PWV (Complior)...
September 13, 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28913723/therapeutic-implications-of-the-molecular-and-immune-landscape-of-triple-negative-breast-cancer
#15
REVIEW
Ana C Gregório, Manuela Lacerda, Paulo Figueiredo, Sérgio Simões, Sérgio Dias, João Nuno Moreira
Treatment and management of breast cancer imposes a heavy burden on public health care, and incidence rates continue to increase. Breast cancer is the most common female neoplasia and primary cause of death among women worldwide. The recognition of breast cancer as a complex and heterogeneous disease, comprising different molecular entities, was a landmark in our understanding of this malignancy. Valuing the impact of the molecular characteristics on tumor behavior enabled a better assessment of a patient's prognosis and increased the predictive power to therapeutic response and clinical outcome...
September 14, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28913361/insulin-resistance-predicts-atherogenic-lipoprotein-profile-in-nondiabetic-subjects
#16
Flávia De C Cartolano, Gabriela D Dias, Maria C P de Freitas, Antônio M Figueiredo Neto, Nágila R T Damasceno
BACKGROUND: Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an atherogenic lipid subfraction profile. METHODS: Complete clinical evaluation and biochemical analysis (lipid, glucose profile, LDL, and HDL subfractions and LDL phenotype and size) were performed in 181 patients...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28912068/angiogenic-imbalance-and-diminished-matrix-metalloproteinase-2-and-9-underlie-regional-decreases-in-uteroplacental-vascularization-and-feto-placental-growth-in-hypertensive-pregnancy
#17
Carlos A Dias-Junior, Juanjuan Chen, Ning Cui, Charles L Chiang, Minglin Zhu, Zongli Ren, Jose S Possomato-Vieira, Raouf A Khalil
Preeclampsia is a form of hypertension-in-pregnancy (HTN-Preg) with unclear mechanism. Generalized reduction of uterine perfusion pressure (RUPP) could be an initiating event leading to uteroplacental ischemia, angiogenic imbalance, and HTN-Preg. Additional regional differences in uteroplacental blood flow could further affect the pregnancy outcome and increase the risk of preeclampsia in twin or multiple pregnancy, but the mechanisms involved are unclear. To test the hypothesis that regional differences in angiogenic balance and matrix metalloproteinases (MMPs) underlie regional uteroplacental vascularization and feto-placental development, we compared fetal and placental growth, and placental and myoendometrial vascularization in the proximal, middle and distal regions of the uterus (in relation to the iliac bifurcation) in normal pregnant (Preg) and RUPP rats...
September 11, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28904664/-pregnancy-and-delivery-in-patients-with-a-personal-history-of-cesarean-section-in-dakar-epidemiological-clinical-therapeutic-and-prognostic-aspects
#18
Cyr Espérance Koulimaya-Gombet, Abdoul Aziz Diouf, Moussa Diallo, Anna Dia, Codou Sène, Jean Charles Moreau, Alassane Diouf
The aim of our study was to determine hospitalization rate for vaginal birth after cesarean section in Pikine, to evaluate the quality of the management of pregnant women with previous cesarean section and to determine prognostic factors of the outcome of a trial of scar. We conducted a retrospective study based on medical records and operational protocols of patients who underwent vaginal birth after cesarean section over the period 1 January 2010 - 31 December 2011. We analyzed socio-demographic data, pregnancy follow-up, therapeutic modalities and prognosis...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904655/assessment-of-potentially-preventable-hospitalizations-in-the-regional-hospital-of-saint-louis-senegal
#19
Abdoul Aziz Ndiaye, Mouhameth Bakhoum, Alioune Badara Tall, Ndeye Fatou Ngom-Gueye, Mohamed Sidy Seck, Boubacar Gueye, Awa Diop-Ba, Awa Gaye, Gallo Papa Sow, Lamine Gueye, Anta Tal-Dia
INTRODUCTION: The "potentially preventable hospitalizations (PPH)'' are hospital admissions that could have been avoided through effective primary care given at the appropriate time. Non-communicable diseases (NCDs), causes of PPH, are the leading cause of death worldwide with significant socioeconomic consequences especially in developing countries. This study aimed to assess the burden of potentially preventable hospitalizations in the St. Louis regional hospital. METHODS: This was a descriptive cross-sectional study...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28903025/experimental-neospora-caninum-infection-in-chickens-gallus-gallus-domesticus-with-oocysts-and-tachyzoites-of-two-recent-isolates-reveals-resistance-to-infection
#20
Solange Oliveira, Juliana Aizawa, Herbert Sousa Soares, Daniela Pontes Chiebao, Márcio Botelho de Castro, Aline S Hora, Marcos Gomes Lopes, Gereon Schares, Mark C Jenkins, Oliver C H Kwok, Ricardo Augusto Dias, Solange Maria Gennari, Jitender P Dubey, Hilda Fátima Jesus Pena
The importance of birds in the biological cycle of Neospora caninum is not clear. We report unsuccessful Neospora infection in chickens (Gallus gallus domesticus) using two isolates of N. caninum. In experiment #1, 30 White Leghorn chickens were orally inoculated with viable N. caninum oocysts (NC-SP1 isolate, 200 oocysts per bird) via the crop at 21days of age. Groups of three birds were euthanised at intervals of 7days (a total of 9weeks) and one group was challenged with the same oocyst dose at 37daysp.i...
September 10, 2017: International Journal for Parasitology
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