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JOURNAL ARTICLE
Deepika V Karade, Vo Quang Huy Phan, H V Rasika Dias
Phenanthroline-based ligands with bulky aryl groups flanking the metal binding pocket enabled the synthesis and detailed investigation of ethylene complexes of copper(I), silver(I), and gold(I), including structural data of [{2,9-bis(2,4,6-triisopropylphenyl)-1,10-phenanthroline}M(C2 H4 )][SbF6 ] (M = Cu, Ag, Au), Additionally, a related copper(I)-ethylene complex with a highly fluorinated ligand is also reported. Gold(I) affects the ethylene moiety significantly as evident from the notable upfield coordination shifts of ethylene carbon signals in the NMR and lengthening of the ethylene CC bond length...
April 23, 2024: Dalton Transactions: An International Journal of Inorganic Chemistry
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JOURNAL ARTICLE
Rafaela G A Costa, Maiara de S Oliveira, Ana Carolina B da C Rodrigues, Suellen L R Silva, Ingrid R S B Dias, Milena B P Soares, Ludmila de Faro Valverde, Clarissa Araujo Gurgel Rocha, Rosane Borges Dias, Daniel P Bezerra
Acute myelogenous leukaemia (AML) originates and is maintained by leukaemic stem cells (LSCs) that are inherently resistant to antiproliferative therapies, indicating that a critical strategy for overcoming chemoresistance in AML therapy is to eradicate LSCs. In this work, we investigated the anti-AML activity of bortezomib (BTZ), emphasizing its anti-LSC potential, using KG-1a cells, an AML cell line with stem-like properties. BTZ presented potent cytotoxicity to both solid and haematological malignancy cells and reduced the stem-like features of KG-1a cells, as observed by the reduction in CD34- and CD123-positive cells...
April 2024: Journal of Cellular and Molecular Medicine
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JOURNAL ARTICLE
Shubham Pai Kuchelkar, Amit Dias, Edwin Gomes, Lydia Dias
BACKGROUND OBJECTIVES: Kyasanur Forest Disease (KFD) is a tick-borne, zoonotic viral hemorrhagic fever, previously known to be endemic to the state of Karnataka, India. The first outbreak of KFD in Goa state was reported in the Sattari taluka, in North Goa in 2015. This study aimed to investigate the outbreak and report the clinical manifestations and risk factors in people diagnosed with KFD. METHODS: A mixed methods approach was used, which included a case series report and 19 in-depth interviews (IDIs) conducted with people diagnosed with KFD...
January 1, 2024: Journal of Vector Borne Diseases
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JOURNAL ARTICLE
Carlota F Prendes, Paolo Spath, Manar Khashram, Nuno Dias, Federico Furlan, Ryan Gouveia E Melo, Enrico Gallitto, Björn Sonesson, Luis Mendes Pedro, Sinead Gormley, Mauro Gargiulo, Anders Wanhainen, Nikolaos Tsilimparis, Kevin Mani
OBJECTIVE: With an increasing life expectancy, more octogenarian patients are referred with complex aortic aneurysms (cAAA). The aim of this study was to evaluate short and mid-term outcomes following fenestrated aortic repair (FEVAR) in octogenarians. SUMMARY BACKGROUND DATA: Few studies looking at octogenarian-specific outcomes with diverging results. METHODS: Retrospective, multicentre cohort study including consecutive patients undergoing elective FEVAR for cAAAs or type IV thoracoabdominal aortic aneurysms between 2007-2022 in eight high-volume centres...
April 22, 2024: Annals of Surgery
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Yuyang Chen, Ruebena Dawes, Hyung Chul Kim, Sarah L Stenton, Susan Walker, Alicia Ljungdahl, Jenny Lord, Vijay S Ganesh, Jialan Ma, Alexandra C Martin-Geary, Gabrielle Lemire, Elston N D'Souza, Shan Dong, Jamie M Ellingford, David R Adams, Kirsten Allan, Madhura Bakshi, Erin E Baldwin, Seth I Berger, Jonathan A Bernstein, Natasha J Brown, Lindsay C Burrage, Kimberly Chapman, Alison G Compton, Chloe A Cunningham, Precilla D'Souza, Emmanuèle C Délot, Kerith-Rae Dias, Ellen R Elias, Carey-Anne Evans, Lisa Ewans, Kimberly Ezell, Jamie L Fraser, Lyndon Gallacher, Casie A Genetti, Christina L Grant, Tobias Haack, Alma Kuechler, Seema R Lalani, Elsa Leitão, Anna Le Fevre, Richard J Leventer, Jan E Liebelt, Paul J Lockhart, Alan S Ma, Ellen F Macnamara, Taylor M Maurer, Hector R Mendez, Stephen B Montgomery, Marie-Cécile Nassogne, Serena Neumann, Melanie O'Leary, Elizabeth E Palmer, John Phillips, Georgia Pitsava, Ryan Pysar, Heidi L Rehm, Chloe M Reuter, Nicole Revencu, Angelika Riess, Rocio Rius, Lance Rodan, Tony Roscioli, Jill A Rosenfeld, Rani Sachdev, Cas Simons, Sanjay M Sisodiya, Penny Snell, Laura St Clair, Zornitza Stark, Tiong Yang Tan, Natalie B Tan, Suzanna El Temple, David R Thorburn, Cynthia J Tifft, Eloise Uebergang, Grace E VanNoy, Eric Vilain, David H Viskochil, Laura Wedd, Matthew T Wheeler, Susan M White, Monica Wojcik, Lynne A Wolfe, Zoe Wolfenson, Changrui Xiao, David Zocche, John L Rubenstein, Eirene Markenscoff-Papadimitriou, Sebastian M Fica, Diana Baralle, Christel Depienne, Daniel G MacArthur, Joanna Mm Howson, Stephan J Sanders, Anne O'Donnell-Luria, Nicola Whiffin
Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed after comprehensive genetic testing, primarily of protein-coding genes 1 . Increasingly, large genome-sequenced cohorts are improving our ability to discover new diagnoses in the non-coding genome. Here, we identify the non-coding RNA RNU4-2 as a novel syndromic NDD gene. RNU4-2 encodes the U4 small nuclear RNA (snRNA), which is a critical component of the U4/U6.U5 tri-snRNP complex of the major spliceosome 2 . We identify an 18 bp region of RNU4-2 mapping to two structural elements in the U4/U6 snRNA duplex (the T-loop and Stem III) that is severely depleted of variation in the general population, but in which we identify heterozygous variants in 119 individuals with NDD...
April 9, 2024: medRxiv
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JOURNAL ARTICLE
Amanda Cristina Reis Gonzaga, Jayane Laís Dias Quintão, Giovane Galdino, Thiago Roberto Lima Romero, Grazielle Caroline da Silva, Virgínia Soares Lemos, Gabriel Henrique Campolina-Silva, Cleida Aparecida de Oliveira, Germán Arturo Bohórquez Mahecha, Igor Dimitri Gama Duarte
INTRODUCTION: Tissue injury results in the release of inflammatory mediators, including a cascade of algogenic substances, which contribute to the development of hyperalgesia. During this process, endogenous analgesic substances are peripherally released to counterbalance hyperalgesia. The present study aimed to investigate whether inflammatory mediators TNF-α, IL-1β, CXCL1, norepinephrine (NE) and prostaglandin E2 (PGE2) may be involved in the deflagration of peripheral endogenous modulation of inflammatory pain by activation of the cholinergic system...
April 20, 2024: Pharmacology
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JOURNAL ARTICLE
Vinicius Duarte Pimentel, Boris Timah Acha, Gabriel Felicio Gomes, João Luiz Macedo de Sousa Cardoso, Charllyton Luis Sena da Costa, Nelson Jorge Carvalho Batista, Daniel Dias Rufino Arcanjo, Wellington Dos Santos Alves, Francisco de Assis Oliveira
ETHNOPHARMACOLOGICAL RELEVANCE: Medicinal plants have shown promise in the search for new treatments of pulmonary emphysema. Anadenanthera colubrina, a species native to the Caatinga biome in northeastern Brazil, is widely recognized and traditionally employed in the treatment of pulmonary diseases. Many studies corroborate popular knowledge about the medicinal applications of A. colubrina, which has demonstrated a remarkable variety of pharmacological properties, however, its anti-inflammatory and antioxidant properties are highlighted...
April 18, 2024: Journal of Ethnopharmacology
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REVIEW
Jordana Borges C Diniz, Francisco Alfonso Rodriguez Elvir, Laís Silva Santana, Sávio Batista, Luisa Glioche Gasparri, João Paulo Mota Telles, Allan Dias Polverini
INTRODUCTION: For patients with drug-resistant epilepsy (DRE) who are not suitable for surgical resection, neuromodulation with vagus nerve stimulation (VNS) is an established approach. However, there is limited evidence of seizure reduction when replacing traditional VNS (tVNS) device with a cardiac-based one (cbVNS). This meta-analysis compares the seizure reduction achieved by replacing tVNS with cbVNS in a population with DRE. METHODS: We systematically searched PubMed, Embase, and Cochrane Central following PRISMA guidelines...
April 6, 2024: Seizure: the Journal of the British Epilepsy Association
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JOURNAL ARTICLE
Gabriela Manco Machado, Ana Clara Falabello Luca, Renata Paz Leal Pereira, Ana Yne Fernandez, Lucas Gabriel Santini Rodrigues, Isabella Petroline Leite, Maximiliano Sergio Cenci, Tatiana Pereira Cenci, Ana Paula Pires Santos, Branca Heloisa Oliveira, Paulo Nadanovsky, Marina Deus Moura Lima, Marcoeli Silva Moura, Edson Hilan Gomes Lucena, Tathiane Larissa Lenzi, Ana Carla Crispim, Fernanda Campos Almeida Carrer, Mariana Gabriel, Claudia Cazal Lira, Carla Vecchione Gurgel, Helder Henrique Costa Pinheiro, Gilberto Alfredo Pucca, Fábio Carneiro Martins, Paola Gondim Calvasina, Maria Fernanda Montezuma Tricoli, Camila Menezes Costa Castelo Branco, Raiza Dias Freitas, José Carlos Pettorossi Imparato, Daniela Prócida Raggio, Tamara Kerber Tedesco, Fausto Medeiros Mendes, Mariana Minatel Braga
BACKGROUND: Important evidence has been constantly produced and needs to be converted into practice. Professional consumption of such evidence may be a barrier to its implementation. Then, effective implementation of evidence-based interventions in clinical practice leans on the understanding of how professionals value attributes when choosing between options for dental care, permitting to guide this implementation process by maximizing strengthens and minimizing barriers related to that...
April 19, 2024: BMC Oral Health
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JOURNAL ARTICLE
Fabiana Duarte, Maria Inês Barradas, Ana Raquel Dias, Carlos Faria, Carina Machado, Carolina Pavão
BACKGROUND: Non-bacterial thrombotic endocarditis (NBTE) is a rare condition marked by sterile vegetations on cardiac valves, often linked to rheumatologic diseases, autoimmune disorders, and advanced solid malignancies. An early diagnosis and treatment of the associated clinical condition are mandatory, although they do not usually eliminate valvular vegetations, making anticoagulation essential to prevent embolic events. Despite variability, the prognosis of NBTE is usually unfavorable due to recurrent embolic events and the severity of the primary condition, typically advanced cancer...
April 19, 2024: Cardio-Oncology
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JOURNAL ARTICLE
Nicola S Diciolla, Patrícia Rebelo, Guilherme Rodrigues, Ana Sofia Grave, Cíntia Dias, Maria Gomes, E Samuel Santos, Zulmira Pereira, Luísa Pereira, Alda Marques
BACKGROUND: Validating walking trails is essential to promote physical activity (PA) safely and confidently in people with COPD. OBJECTIVES: We aimed to validate predetermined light, moderate, and vigorous intensities of walking trails in people with COPD. METHODS: This cross-sectional study included individuals with COPD walking in predetermined light, moderate and vigorous intensity trails. Activity intensity and volume outcomes were collected...
April 18, 2024: Heart & Lung: the Journal of Critical Care
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JOURNAL ARTICLE
Eduardo Delabio Auer, Valéria Bumiller-Bini Hoch, Emiliano Borges da Silva, Yohan Ricci Zonta, Luciane Alarcão Dias-Melicio, Thelma Larocca Skare, Vanessa F Picceli, Iara José Messias-Reason, Angelica Beate Winter Boldt
Neutrophil extracellular traps (NETs) are cell-extruded DNA strands coated with neutrophils' nuclear proteins and enzymes from cytotoxic granules, produced by NETosis, a cell death pathway. They perform an important defensive role in innate immunity, but their increased production and/or inefficient degradation expose new antigens, such as DNA or citrullinated histone peptides, triggering autoimmunity. This study aimed to access possible associations between serum NETs levels with epidemiological, clinical, and serological data from a well-characterized SLE Brazilian patients' cohort...
April 5, 2024: Immunobiology
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JOURNAL ARTICLE
Luciana de Souza Santos, Marília Harumi Higuchi Dos Santos Rehder, Marcelo Vailati Negrao, Beatriz R Goes-Santos, Edgar Toschi-Dias, Camila Jordão Paixão, Ursula Urias, Natali Schiavo Giannetti, Ludhmila A Hajjar, Roberto Kalil Filho, Carlos E Negrão
BACKGROUND: It is unclear whether muscle blood flow (MBF) is altered in long-term Hodgkin Lymphoma (HL) survivors. We test the hypothesis that: 1) MBF response during mental stress (MS) is impaired in long-term HL survivors; 2) Aerobic exercise training combined with local strength exercise (ET) restores MBF responses during MS in these survivors. METHODS: Eighteen 5-year HL survivors and 10 aged-paired healthy subjects (HC) were studied. Twenty HL survivors were randomly divided into two groups: Exercise-trained (HLT, n=10) and untrained (HLUT, n=10)...
April 19, 2024: American Journal of Physiology. Heart and Circulatory Physiology
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JOURNAL ARTICLE
Statine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro).
Pedro Henrique R de A Azevedo, Priscila G Camargo, Larissa E C Constant, Stephany da S Costa, Celimar Sinézia Silva, Alice S Rosa, Daniel D C Souza, Amanda R Tucci, Vivian N S Ferreira, Thamara Kelcya F Oliveira, Nathalia R R Borba, Carlos R Rodrigues, Magaly G Albuquerque, Luiza R S Dias, Rafael Garrett, Milene D Miranda, Diego Allonso, Camilo Henrique da S Lima, Estela Maris F Muri
COVID-19 is a multisystemic disease caused by the SARS-CoV-2 airborne virus, a member of the Coronaviridae family. It has a positive sense single-stranded RNA genome and encodes two non-structural proteins through viral cysteine-proteases processing. Blocking this step is crucial to control virus replication. In this work, we reported the synthesis of 23 statine-based peptidomimetics to determine their ability to inhibit the main protease (Mpro) activity of SARS-CoV-2. Among the 23 peptidomimetics, 15 compounds effectively inhibited Mpro activity by 50% or more, while three compounds (7d, 8e, and 9g) exhibited maximum inhibition above 70% and IC50 < 1 µM...
April 18, 2024: Scientific Reports
#15
JOURNAL ARTICLE
Rita Ornelas Saraiva, Verónica Pavão Borges, Mário Jorge Silva, Rafaela Loureiro, Tiago Capela, Gonçalo Ramos, Jorge Canena, António Mateus Dias, Rui Alves, João Coimbra
INTRODUCTION: Experience with endoscopic retrograde cholangiopancreatography (ERCP) in the pediatric population is limited. Few medical centers have experts specifically trained in pediatric therapeutic endoscopy. As a result, patients are generally referred to adult endoscopists with high experience in the procedure. The aim of this study was to characterize the experience of an adult endoscopy unit with ERCP on pediatric patients, with a special focus on very young patients. METHODS: We retrospectively analyzed indications, technical success rate, final clinical diagnosis, and complications of ERCPs in children <18 years at our tertiary referral hospital center between January 1994 and June 2022...
April 2024: GE Portuguese Journal of Gastroenterology
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JOURNAL ARTICLE
Erika Bastos Lima Freire, Catarina Brasil d'Alva, Mayara Ponte Madeira, Grayce Ellen da Cruz Paiva Lima, Virginia Oliveira Fernandes, Lindenberg Barbosa Aguiar, Leonardo Barreira Portella, Renan Galvão Ozório, Clarisse Mourão Melo Ponte, Ana Paula Dias Rangel Montenegro, Renan Magalhães Montenegro Junior
INTRODUCTION: Congenital Generalized Lipodystrophy (CGL) is a rare autosomal recessive disease caused by mutations in genes responsible for the formation and development of adipocytes. Bone abnormalities are described. However, there is a scarcity of data. OBJECTIVE: To describe bone characteristics in a large CGL1 and 2 case series. METHODS: Cross-sectional study that assessed bone radiological features of CGL patients of a reference hospital in Fortaleza (CE), Brazil...
2024: Frontiers in Endocrinology
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JOURNAL ARTICLE
V M Roriz, Mll Santana, V L Boaventura, E D Zanotto, O Peitl, D R Dias
OBJECTIVE: The objective of this study was to compare the efficacy of Biosilicate and Duraphat in the treatment of dentin hypersensitivity (DH). METHODS AND MATERIALS: This clinical trial was conducted with young adults presenting DH. A visual analogue scale (VAS) was used to assess the level of pain, using volatile and tactile tests. Forty participants presenting two teeth with DH were included, and these teeth were divided into two groups according to the treatment: Biosilicate or Duraphat...
April 17, 2024: Operative Dentistry
#18
JOURNAL ARTICLE
Juliana Raissa Oliveira Ricarte, Maria Dinara de Araújo Nogueira, Matheus Aragão Dias Firmino, Luis Felipe Nunes de Oliveira, Ashley Brito Valentim, Géssica de Souza Martins, Ana Cecília Pereira Dantas, Nayeli Silva Lima Matias, Enairton Vinicius da Silva Rocha, Kaluce Gonçalves de Sousa Almondes, Carla Soraya Costa Maia
RATIONALE/OBJECTIVE: The phase angle (PhA) is a measurement obtained from the resistance and reactance found in the bioelectrical impedance examination and is useful in assessing nutritional status and in assessing cardiometabolic diseases. Therefore, the objective was to correlate the phase angle to the anthropometric variables of cardiometabolic risk (CMR) in children and adolescents. SUBJECTS/METHODS: Weight, height, body mass index (BMI), waist circumference (WC) and neck circumference (NC), waist-to-height ratio (WHtR), and PhA of 1231 children and adolescents aged between 5 and 18 years were assessed...
April 17, 2024: European Journal of Clinical Nutrition
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JOURNAL ARTICLE
Andre Roncon Dias, Marina A Pereira, Marcus F K P Ramos, Rodrigo José de Oliveira, Osmar Kenji Yagi, Ulysses Ribeiro
BACKGROUND: Robot-assisted gastrectomy (RG) has been shown to be safe and feasible in the treatment of gastric cancer (GC). However, it is unclear whether RG is equivalent to laparoscopic gastrectomy (LG), especially in the Western world. Our objective was to compare the outcomes of RG and LG in GC patients. METHODS: We reviewed all gastric adenocarcinoma patients who underwent curative gastrectomy by minimally invasive approach in our institution from 2009 to 2022...
April 17, 2024: Journal of Surgical Oncology
#20
JOURNAL ARTICLE
Déthié Ngom, Aliou Khoulé, Elisabeth Thérèse Faye, Ousseynou Sène, Sokhna Maymouna Diop, Samba Niang Sagne, Mamadou Korka Diallo, Moussa Dia, Mamadou Aliou Barry, Yoro Diaw, Mamoudou Bocoum, El Hadji Mamadou Ndiaye, Yoro Sall, Boly Diop, Oumar Faye, Ousmane Faye, Mawlouth Diallo, Etienne Simon-Lorière, Anavaj Sakuntabhai, Gamou Fall, Diawo Diallo
OBJECTIVE: Crimean-Congo haemorrhagic fever (CCHF) is a severe zoonotic arboviral disease that occurs widely in Eastern and Western Europe, Asia and Africa. The disease is becoming of growing public health importance in Senegal. However, analysis of tick infestation, CCHF virus (CCHFV) circulation extent and risk factors during ongoing outbreak are scarce. A thorough outbreak investigation was carried out during a CCHF outbreak in Podor (Northern Senegal) in August 2022. METHODS: Ticks and blood samples were collected from animals (cattle, goats and sheep) randomly selected from confirmed CCHF human cases houses, neighbourhoods and surrounding villages...
April 16, 2024: Zoonoses and Public Health
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