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https://www.readbyqxmd.com/read/29165666/differences-in-outcomes-over-time-with-exclusive-enteral-nutrition-compared-to-steroids-in-children-with-mild-to-moderate-crohn-s-disease-results-from-the-growth-cd-study
#1
Noa Cohen-Dolev, Malgorata Sladek, Seamus Hussey, Dan Turner, Gabor Veres, Sibylle Koletzko, Javier Martin de Carpi, Annamaria Staiano, Ron Shaoul, Paolo Lionetti, Jorge Amil Dias, Anders Paerregaard, Federica Nuti, Tamar Pfeffer Gik, Tomer Ziv-Baran, Sivan Ben Avraham Shulman, Chen Sarbagili Shabat, Rotem Sigall Boneh, Richard K Russell, Arie Levine
Background: Exclusive enteral nutrition (EEN) and corticosteroids (CS) both induce similar rates of remission in mild to moderate pediatric Crohn's disease (CD), but differ with regard to mucosal healing. Our goal was to evaluate if EEN at diagnosis was superior to CS for improving long term outcomes. Methods: We prospectively followed newly diagnosed children <17 years with mild to moderate disease at baseline for two years in the GROWTH CD study. Patients were evaluated at baseline and at 8, 12, 78, and 104 weeks...
November 18, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29165455/isomer-specific-detection-in-the-uv-photodissociation-of-the-propargyl-radical-by-chirped-pulse-mm-wave-spectroscopy-in-a-pulsed-quasi-uniform-flow
#2
Bernadette M Broderick, Nicolas Suas-David, Nureshan Dias, Arthur G Suits
Isomer-specific detection and product branching fractions in the UV photodissociation of the propargyl radical is achieved through the use of chirped-pulse Fourier-transform mm-wave spectroscopy in a pulsed quasi-uniform flow (CPUF). Propargyl radicals are produced in the 193 nm photodissociation of 1,2-butadiene. Absorption of a second photon leads to H atom elimination giving three possible C3H2 isomers: singlets cyclopropenylidene (c-C3H2) and propadienylidene (l-C3H2), and triplet propargylene ((3)HCCCH)...
November 22, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29165046/phytophthora-parasitica-effector-pprxlr2-suppresses-nicotiana-benthamiana-immunity
#3
Ronaldo J D Dalio, Heros José Máximo, Tiago Silva Oliveira, Renata Dias, Michele Breton, Henrique Leme Felizatti, Marcos Antonio Antonio Machado
Phytophthora species secrete several classes of effector proteins during interaction with their hosts. These proteins can have multiple functions including modulation of host physiology and immunity. The RxLR effectors have the ability to enter plant cells using the plant machinery. Some of these effectors have been characterized as immunity suppressors; however, very little is known about their functions in the interaction between Phytophthora parasitica and its hosts. Using a bioinformatics pipeline, we have identified 172 candidate RxLR effectors (CREs) in the isolate IAC 01_95 of P...
November 22, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/29164276/physical-activity-and-heart-rate-variability-in-adolescents-with-abdominal-obesity
#4
Breno Quintella Farah, Aluísio Andrade-Lima, Antônio Henrique Germano-Soares, Diego Giulliano Destro Christofaro, Mauro Virgílio Gomes de Barros, Wagner Luiz do Prado, Raphael M Ritti-Dias
Physical activity is a protective factor for autonomic dysfunction. However, whether this occurs in adolescents with abdominal obesity is still unclear. Thus, the aim of this study was to analyze the association between physical activity and heart rate variability (HRV) in adolescents with and without abdominal obesity. This cross-sectional study included 1152 boys (age: 17 ± 1 years). HRV measures of time (root mean square of the squared differences between adjacent normal RR intervals-RMSSD and the percentage of adjacent intervals over 50 ms-PNN50) and frequency domains (balance sympathetic-vagal-LF/HF) were evaluated, as well as total physical activity, commuting physical activity, leisure-time physical activity, and abdominal obesity...
November 21, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29160903/smoking-cessation-leads-to-changes-in-survivin-expression-in-oral-mucosa
#5
Celina Faig Lima, Erica Crastechini, Nathalia Curto Dos Santos, Ana Carolina Prado Ribeiro, Thais Bianca Brandão, Félix Cristiano Ferreira de Castro, Jaqueline Scholz Issa, Janete Dias Almeida
BACKGROUND: Survivin is an inhibitor protein of apoptosis and play a role in oral carcinogenesis mechanism. METHODS: This aim of this study was to evaluate the effect of smoking in survivin expression of oral mucosa of chronic smokers with and without oral squamous cell carcinoma (OSCC). The study was composed of three groups: Group 1 - 26 patients smoking more than 20 cigarettes/day/10 years without either history of oral malignant neoplasia or visible clinical signs in the examined site; Group 2 - 26 patients with OSCC; Group 3 - 22 patients surgically treated for OSCC for at least 1 month...
November 21, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29160369/biomechanical-study-of-the-effect-of-platelet-rich-plasma-on-the-treatment-of-medial-collateral-ligament-lesion-in-rabbits
#6
Eduardo Louzada da Costa, Luiz Eduardo Moreira Teixeira, Bruno Jannotti Pádua, Ivana Duval de Araújo, Leonardo de Souza Vasconcellos, Luide Scalioni Borges Dias
PURPOSE: To evaluate the use of platelet-rich plasma in the early stages of healing of traumatic injury of the medial collateral ligament in the knee of rabbits. METHODS: Thirty rabbits were subjected to surgical lesion of the medial collateral ligament. Of these, 16 were treated with platelet-rich plasma and 14 with saline (control). After 3 and 6 weeks of treatment, 50% of the animals from each group were sacrificed, and biomechanical tests were performed on the injured ligament to compare the tensile strength between the two groups...
October 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29160223/hematology-and-condition-factor-of-tui-chub-and-fathead-minnow-parasitized-by-nematode-from-upper-klamath-lake-oregon-usa
#7
Maurício L Martins, Marcos Tavares-Dias, Andrew J Janik, Michael L Kent, Gabriela T Jerônimo
This study evaluated the hematological profile and condition factor (Kn) of tui chub Siphateles bicolor and fathead minnow Pimephales promelas and their associations with larvae of Contracaecum sp. infection of the heart. A total of 30 tui chub and 17 fathead minnow were collected from Upper Klamath Lake, Oregon, USA, measured, and weighed and blood was drawn for hematological analysis. Nematode larvae parasitized tui chub with a prevalence of 50% and mean intensity of 1.40, while 11.8% of fathead minnow were parasitized at a mean intensity of 1...
November 21, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/29159974/ultrasonographic-anatomy-of-the-atlanto-occipital-region-and-ultrasound-guided-cerebrospinal-fluid-collection-in-rabbits-oryctolagus-cuniculus
#8
Carlo Anselmi, Sara Dias, Jaume Martorell, Marc Navarro, Yvonne Espada, Rosa Novellas
Cerebrospinal fluid analyses are important for diagnosis of neurologic problems in rabbits and for translational research projects using rabbits as models. Blind puncture of the cisterna magna is the current standard technique for sampling cerebrospinal fluid in this species. However, the complexity and small size of the cisterna magna and surrounding structures are limitations of this technique. Aims of this prospective, anatomic, pilot study were to (1) describe the normal anatomy of the atlanto-occipital region, (2) describe ultrasonographic anatomic landmarks, and (3) develop and evaluate a technique for ultrasound-guided puncture of the cisterna magna for cerebrospinal fluid sampling in rabbits...
November 20, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/29157062/dna-barcoding-techniques-used-to-identify-the-shared-ichthyofauna-between-the-pantanal-floodplain-and-upper-parana-river
#9
Guilherme J da Costa-Silva, Fernando Yuldi Ashikaga, Cristiane Kioko Shimabukuro Dias, Luiz Henrique Garcia Pereira, Fausto Foresti, Claudio Oliveira
The biological invasion process is widely debated topic, as the population depletion of some species and the extinction of others are related to this process. To accelerate the identification of species and to detect non-native forms, new tools are being developed, such as those based on genetic markers. This study aimed to use Barcode DNA methodology to identify fish species that had translocated between the Parana and Paraguay River Basins. Based on a database of two studies that were conducted in these regions, 289 sequences of Cytochrome Oxidase C subunit 1 (COI) were used for General Mixed Youle Coalecent (GMYC) analysis, including 29 morphospecies that were sampled in both river basins...
November 20, 2017: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/29153860/the-antimicrobial-peptide-hs-1-inhibits-dengue-virus-infection
#10
Juliana M C Monteiro, Michelle D Oliveira, Roberto S Dias, Lorena Nacif-Marçal, Renato N Feio, Sukarno O Ferreira, Leandro L Oliveira, Cynthia C Silva, Sérgio O Paula
Dengue virus (DENV) is an arbovirus that belongs to the Flaviviridae family. Studies reveal that peptides secreted by amphibians have many functions, such as antiviral and antimicrobial activities. As there is no antiviral drug effective against the DENV, the antiviral activity of a synthetic peptide called HS-1, derived from the secretion of the anuran Hypsiboas semilineatus, has been evaluated. The assays of neutralization in the Vero cells show a complete inhibition of infection of the serotypes 2 and 3...
November 16, 2017: Virology
https://www.readbyqxmd.com/read/29145967/bone-intramedullary-reaming-grafts-the-fracture-site-with-cd146-skeletal-progenitors-and-downmodulates-the-inflammatory-environment
#11
Leonardo R Rocha, Rafaela C Sartore, Ana C Leal, Rhayra B Dias, Maria Eugenia L Duarte, João Antônio M Guimarães, Danielle C Bonfim
INTRODUCTION: Femoral shaft fractures generally occur in young adults following a high-energy trauma and are prone to delayed union/non-union. Novel therapies to stimulate bone regeneration will have to mimic some of the aspects of the biology of fracture healing; however, which are these aspects is unclear. Locked intramedullary nailing is the current treatment of choice for the stabilisation of femur shaft fractures, and it is associated with accelerated healing and increased union rates...
October 2017: Injury
https://www.readbyqxmd.com/read/29143881/rmce-based-insect-cell-platform-to-produce-membrane-proteins-captured-on-hiv-1-gag-virus-like-particles
#12
João Vidigal, Bárbara Fernandes, Mafalda M Dias, Marco Patrone, António Roldão, Manuel J T Carrondo, Paula M Alves, Ana P Teixeira
Conformationally complex membrane proteins (MPs) are therapeutic targets in many diseases, but drug discovery has been slowed down by the lack of efficient production tools. Co-expression of MPs with matrix proteins from enveloped viruses is a promising approach to obtain correctly folded proteins at the surface of virus-like particles (VLPs), preserving their native lipidic environment. Here, we implemented a site-specific recombinase-mediated cassette exchange (RMCE) strategy to establish a reusable HIV-1 Gag-expressing insect cell line for fast production of target MPs on the surface of Gag-VLPs...
November 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29142433/prosopis-juliflora-pods-alkaloid-rich-fraction-in-vitro-anthelmintic-activity-on-goat-gastrointestinal-parasites-and-its-cytotoxicity-on-vero-cells
#13
Helimar Gonçalves Lima, Danilo Cavalcante Gomes, Nathália Silva Santos, Êuder Reis Dias, Mariana Borges Botura, Maria José Moreira Batatinha, Alexsandro Branco
Background: This study was designed to assess the in vitro anthelmintic activity of the fraction containing alkaloid from Prosopis juliflora pods on goat gastrointestinal nematodes using the egg hatch assay (EHA), larval migration inhibition assay (LMIA), and larval motility assay (LMA). Materials and Methods: The alkaloid-rich fraction (AF) - content juliprosopine as major alkaloid - was obtained from ethyl acetate extract after fractionation in Sephadex LH-20 chromatography column and its characterization were made by nuclear magnetic resonance analysis together with literature data comparison...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29140377/influence-of-the-prosthetic-index-on-fracture-resistance-of-morse-taper-dental-implants
#14
Karla Zancopé, Caio César Dias Resende, Carolina Guimarães Castro, Rafael Calixto Salatti, Flávio Domingues das Neves
PURPOSE: Manufacturers have inserted a prosthetic index, an internal hexagon to guide prosthetic components inside Morse taper implants. However, it is still unclear if this mechanism could decrease the mechanical strength of Morse taper implants. The aim of this study was to evaluate the influence of the prosthetic index inside Morse taper implants on fracture resistance compared with nonindexed implants. MATERIALS AND METHODS: Fifty-seven Morse taper implants, with 11...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29139609/development-of-a-high-throughput-method-based-on-thin-film-microextraction-using-a-96-well-plate-system-with-a-cork-coating-for-the-extraction-of-emerging-contaminants-in-river-water-samples
#15
Lucas Morés, Adriana Neves Dias, Eduardo Carasek
In this study, a new method was developed in which a biosorbent material is used as the extractor phase in conjunction with a recently described sample preparation technique called thin-film microextraction and a 96-well plate system. The method was applied to the determination of emerging contaminants, such as 3-(4-methylbenzylidene) camphor, ethylparaben, triclocarban and bisphenol A, in water samples. The separation and detection of the analytes were performed by high-performance liquid chromatography with diode array detection...
November 15, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29138533/comparison-of-visual-outcomes-after-bilateral-implantation-of-a-diffractive-trifocal-intraocular-lens-and-blended-implantation-of-an-extended-depth-of-focus-intraocular-lens-with-a-diffractive-bifocal-intraocular-lens
#16
André Lins de Medeiros, André Gustavo de Araújo Rolim, Antonio Francisco Pimenta Motta, Bruna Vieira Ventura, César Vilar, Mário Augusto Pereira Dias Chaves, Pedro Carlos Carricondo, Wilson Takashi Hida
Purpose: The purpose of this study was to compare the visual outcomes and subjective visual quality between bilateral implantation of a diffractive trifocal intraocular lens, Alcon Acrysof IQ(®) PanOptix(®) TNFT00 (group A), and blended implantation of an extended depth of focus lens, J&J Tecnis Symfony(®) ZXR00 with a diffractive bifocal intraocular lens, J&J Vision Tecnis(®) ZMB00 (group B). Methods: This prospective, nonrandomized, consecutive, comparative study included the assessment of 40 eyes in 20 patients implanted with multifocal intraocular lens...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29138300/high-zika-virus-seroprevalence-in-salvador-northeastern-brazil-limits-the-potential-for-further-outbreaks
#17
Eduardo Martins Netto, Andres Moreira-Soto, Celia Pedroso, Christoph Höser, Sebastian Funk, Adam J Kucharski, Alexandra Rockstroh, Beate M Kümmerer, Gilmara Souza Sampaio, Estela Luz, Sara Nunes Vaz, Juarez Pereira Dias, Fernanda Anjos Bastos, Renata Cabral, Thomas Kistemann, Sebastian Ulbert, Xavier de Lamballerie, Thomas Jaenisch, Oliver J Brady, Christian Drosten, Manoel Sarno, Carlos Brites, Jan Felix Drexler
During 2015 to 2016, Brazil reported more Zika virus (ZIKV) cases than any other country, yet population exposure remains unknown. Serological studies of ZIKV are hampered by cross-reactive immune responses against heterologous viruses. We conducted serosurveys for ZIKV, dengue virus (DENV), and Chikungunya virus (CHIKV) in 633 individuals prospectively sampled during 2015 to 2016, including microcephaly and non-microcephaly pregnancies, HIV-infected patients, tuberculosis patients, and university staff in Salvador in northeastern Brazil using enzyme-linked immunosorbent assays (ELISAs) and plaque reduction neutralization tests...
November 14, 2017: MBio
https://www.readbyqxmd.com/read/29137873/-validity-time-of-normal-preoperative-tests-for-surgical-reintervention-and-the-impact-on-postoperative-outcomes
#18
Lafayete William Ferreira Ramos, Cristiano F Souza, Ivan Wilson Hossni Dias, Rogério G Oliveira, Bárbara Cristina, Marcelo Calil, João Carlos Sampaio Góes
BACKGROUND AND OBJECTIVE: There are few data defining the period of time in which preoperative tests can be considered valid. The purpose of this study was to determine the likelihood of changes in the results of preoperative tests previously normal in relation to time, and the impact of these changes on postoperative outcomes. METHODS: A total of 970 patients with normal preoperative tests before the first surgery and who required a new intervention were included...
November 11, 2017: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29137705/novel-approach-to-high-throughput-determination-of-endocrine-disruptors-using-recycled-diatomaceous-earth-as-a-green-sorbent-phase-for-thin-film-solid-phase-microextraction-combined-with-96-well-plate-system
#19
Nicolas Kirschner, Adriana Neves Dias, Dilma Budziak, Cristian Berto da Silveira, Josias Merib, Eduardo Carasek
A sustainable approach to TF-SPME is presented using recycled diatomaceous earth, obtained from a beer purification process, as a green sorbent phase for the determination of bisphenol A (BPA), benzophenone (BzP), triclocarban (TCC), 4-methylbenzylidene camphor (4-MBC) and 2-ethylhexyl-p-methoxycinnamate (EHMC) in environmental water samples. TF-SPME was combined with a 96-well plate system allowing for high-throughput analysis due to the simultaneous extraction/desorption up to 96 samples. The proposed sorbent phase exhibited good stability in organic solvents, as well as satisfactory analytical performance...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29137304/monocarboxylate-transporter-1-mct1-a-tool-to-stratify-acute-myeloid-leukemia-aml-patients-and-a-vehicle-to-kill-cancer-cells
#20
Filipa Lopes-Coelho, Carolina Nunes, Sofia Gouveia-Fernandes, Rita Rosas, Fernanda Silva, Paula Gameiro, Tânia Carvalho, Maria Gomes da Silva, José Cabeçadas, Sérgio Dias, Luís G Gonçalves, Jacinta Serpa
Dysregulation of glucose/lactate dynamics plays a role in cancer progression, and MCTs are key elements in metabolic remodeling. VEGF is a relevant growth factor in the maintenance of bone marrow microenvironment and it is also important in hematological diseases. Our aim was to investigate the role of VEGF in the metabolic adaptation of Acute myeloid leukemia (AML) cells by evaluating the metabolic profiles and cell features according to the AML lineage and testing lactate as a metabolic coin. Our in vitro results showed that AML promyelocytic (HL60) and monocytic (THP1) (but not erythroid- HEL) lineages are well adapted to VEGF and lactate rich environment...
October 10, 2017: Oncotarget
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