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Association schizophrenia logistic regression

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https://www.readbyqxmd.com/read/28919292/treatment-patterns-health-care-resource-utilization-and-spending-in-medicaid-beneficiaries-initiating-second-generation-long-acting-injectable-agents-versus-oral-atypical-antipsychotics
#1
Dominic Pilon, Neeta Tandon, Marie-Hélène Lafeuille, Rhiannon Kamstra, Bruno Emond, Patrick Lefebvre, Kruti Joshi
PURPOSE: Second-generation long-acting injectable therapies (SGA-LAIs) may reduce health care resource utilization (HRU) and health care costs compared with daily oral atypical antipsychotics (OAAs) in patients with schizophrenia due to reduced dosing frequency, delivery/monitoring by a health care provider, and improved adherence. The aim of the present study was to compare treatment patterns, HRU, and Medicaid spending in patients with schizophrenia initiated on SGA-LAIs (overall and according to agent) versus OAAs...
September 14, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28887181/treatment-resistant-schizophrenia-and-neurological-soft-signs-may-converge-on-the-same-pathology-evidence-from-explanatory-analysis-on-clinical-psychopathological-and-cognitive-variables
#2
Andrea de Bartolomeis, Emiliano Prinzivalli, Gemma Callovini, Luigi D'Ambrosio, Benedetta Altavilla, Camilla Avagliano, Felice Iasevoli
Here, we investigated neurological soft signs (NSSs) in treatment resistant schizophrenia (TRS) vs treatment responder schizophrenia (SZ) patients. TRS is a severe condition, affecting approximately one-third of schizophrenia patients and representing a relevant clinical challenge. NSSs are neurological abnormalities reportedly described in schizophrenia patients and linked to dysregulated network connections. We explored the possibility that NSSs may be: i) more severe in TRS patients; ii) differentially associated to clinical/cognitive variables in TRS vs SZ; iii) predictive of having TRS...
September 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28861176/prevalence-of-obesity-and-diabetes-in-patients-with-schizophrenia
#3
Aniyizhai Annamalai, Urska Kosir, Cenk Tek
AIM: To compare the prevalence of diabetes in patients with schizophrenia treated at a community mental health center with controls in the same metropolitan area and to examine the effect of antipsychotic exposure on diabetes prevalence in schizophrenia patients. METHODS: The study was a comprehensive chart review of psychiatric notes of patients with schizophrenia and schizoaffective disorder treated at a psychosis program in a community mental health center. Data collected included psychiatric diagnoses, diabetes mellitus diagnosis, medications, allergies, primary care status, height, weight, body mass index (BMI), substance use and mental status exam...
August 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28834883/effect-of-charted-mental-illness-on-reperfusion-therapy-in-hospitalized-patients-with-an-acute-myocardial-infarction-in-florida
#4
Thomas R Campi, Sharon George, Diego Villacís, Melissa Ward-Peterson, Noël C Barengo, Juan C Zevallos
Patients with mental illness carry risk factors that predispose them to excess cardiovascular mortality from an acute myocardial infarction (AMI) compared to the general population. The aim of this study was to determine if patients with AMI and charted mental illness (CMI) received less reperfusion therapy following an AMI, compared to AMI patients without CMI in a recent sample population from Florida.A secondary analysis of data was conducted using the Florida Agency for Health Care Administration (FL-AHCA) hospital discharge registry...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28812245/association-of-elements-with-schizophrenia-and-intervention-of-selenium-supplements
#5
Zhe Li, Yumei Liu, Xia Li, Wen Ju, Guanrui Wu, Xiaomei Yang, Xiaofeng Fu, Xibao Gao
The purpose of this study is to explore more trace elements (zinc, potassium, copper, iron, boron, manganese, selenium, chromium and cadmium elements) in addition to calcium, magnesium, lead and arsenic in the sera of patients with schizophrenia and the general population in China and to determine the effect of selenium on schizophrenia patients. Participants were collected from the Pingyin County Mental Health Hospital and Pingyin County. A t test was used to analyse the differences between schizophrenia patients and healthy subjects, and element content differences in gender...
August 15, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28806363/clinical-epidemiology-of-single-versus-multiple-substance-use-disorders-polysubstance-use-disorder
#6
Ish P Bhalla, Elina A Stefanovics, Robert A Rosenheck
OBJECTIVE: While research on substance abuse has largely focused on people who have a single substance use disorder (SUD), many people abuse multiple substances. Studies have yet to examine the distinctive characteristics of patients diagnosed with more than 1 SUD and how those with polysubstance use disorder (PSUD) differ from those with a single SUD. METHODS: National Veterans Health Administration data from fiscal year 2012 were used to compare veterans diagnosed 1 SUD to veterans diagnosed with 2-3, and >3 SUDs on demographic characteristics, psychiatric and medical diagnoses, medical and psychiatric service utilization, and psychotropic medication fills...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28792989/-factors-associated-with-perception-of-improvement-by-users-of-centers-for-psychosocial-care-in-the-south-of-brazil
#7
Uiasser Thomas Franzmann, Luciane Prado Kantorski, Vanda Maria da Rosa Jardim, Carlos Alberto Dos Santos Treichel, Michele Mandagará de Oliveira, Fabiane Machado Pavani
This study aimed to investigate factors associated with perceived improvement among users of Centers for Psychosocial Care. This was a cross-sectional study of 1,493 users of Centers for Psychosocial Care in the South of Brazil. Users' perceived improvement was assessed by Perceived Change Scale - Patients (PCS-Patients). Associated factors were investigated using logistic regression guided by a hierarchical model, with statistical significance set at p < 0.05. Factors associated with the outcome were: state where the Center for Psychosocial Care was located, paid work, diagnosis of schizophrenia, age at diagnosis < 18 years, longer time attending the center, ease of access, and involvement in the evaluation...
August 7, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28792563/-initiating-an-antipsychotic-drug-treatment-for-schizophrenia-the-situation-in-quebec-canada-from-1998-to-2006
#8
Jean-Daniel Carrier, Lucie Blais, Alan Cohen, Josiane Courteau, Pasquale Roberge, Annie Larouche, Sylvain Grignon, Marie-Josée Fleury, Alain Lesage, Marie-France Demers, Marc-André Roy, André Delorme, Alain Vanasse
Objectives To describe factors associated with the following characteristics of the first prescription of an antipsychotic drug treatment (ADT): 1) prescribing physician type (psychiatrist vs. general practitioner); 2) second-generation vs. first-generation antipsychotic drug; 3) in conjunction with at least one additional antipsychotic drug (multitherapy); 4) never renewed by the patient.Methods This is a pharmacoepidemiologic study using administrative data from the Régie de l'assurance maladie du Québec (RAMQ), the public healthcare insurer in Quebec, Canada...
2017: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/28789791/serious-mental-illness-and-medical-comorbidities-findings-from-an-integrated-health-care-system
#9
Amber L Bahorik, Derek D Satre, Andrea H Kline-Simon, Constance M Weisner, Cynthia I Campbell
OBJECTIVE: To examine the odds associated with having medical comorbidities among patients with serious mental illness (SMI) in a large integrated health system. METHOD: In a secondary analysis of electronic health record data, this study identified 25,090 patients with an ICD-9 SMI diagnosis of bipolar disorder (n=20,308) or schizophrenia (n=4782) and 25,090 controls who did not have a SMI, matched on age, gender, and medical home facility. Conditional logistic regressions compared the odds associated with having nine medical comorbidity categories and fifteen chronic or serious conditions among patients with SMI versus controls...
September 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28758885/dimensional-traits-of-schizotypy-associated-with-glycine-receptor-glra1-polymorphism-an-exploratory-candidate-gene-association-study
#10
Anvi K Vora, Amanda M Fisher, Antonia S New, Erin A Hazlett, Margaret McNamara, Qiaoping Yuan, Zhifeng Zhou, Colin Hodgkinson, David Goldman, Larry J Siever, Panos Roussos, M Mercedes Perez-Rodriguez
Schizotypy captures the underlying genetic vulnerability to schizophrenia. However, the genetic underpinnings of schizotypy remain unexplored. The authors examined the relationship between single nucleotide polymorphisms (SNPs) and schizotypy. A sample of 137 subjects (43 healthy controls, 34 subjects with schizotypal personality disorder [SPD], 32 with borderline personality disorder, and 25 with other personality disorders) completed the Schizotypal Personality Questionnaire (SPQ). Subjects were genotyped using a custom array chip...
July 31, 2017: Journal of Personality Disorders
https://www.readbyqxmd.com/read/28750581/rare-genome-wide-copy-number-variation-and-expression-of-schizophrenia-in-22q11-2-deletion-syndrome
#11
Anne S Bassett, Chelsea Lowther, Daniele Merico, Gregory Costain, Eva W C Chow, Therese van Amelsvoort, Donna McDonald-McGinn, Raquel E Gur, Ann Swillen, Marianne Van den Bree, Kieran Murphy, Doron Gothelf, Carrie E Bearden, Stephan Eliez, Wendy Kates, Nicole Philip, Vandana Sashi, Linda Campbell, Jacob Vorstman, Joseph Cubells, Gabriela M Repetto, Tony Simon, Erik Boot, Tracy Heung, Rens Evers, Claudia Vingerhoets, Esther van Duin, Elaine Zackai, Elfi Vergaelen, Koen Devriendt, Joris R Vermeesch, Michael Owen, Clodagh Murphy, Elena Michaelovosky, Leila Kushan, Maude Schneider, Wanda Fremont, Tiffany Busa, Stephen Hooper, Kathryn McCabe, Sasja Duijff, Karin Isaev, Giovanna Pellecchia, John Wei, Matthew J Gazzellone, Stephen W Scherer, Beverly S Emanuel, Tingwei Guo, Bernice E Morrow, Christian R Marshall
OBJECTIVE: Chromosome 22q11.2 deletion syndrome (22q11.2DS) is associated with a more than 20-fold increased risk for developing schizophrenia. The aim of this study was to identify additional genetic factors (i.e., "second hits") that may contribute to schizophrenia expression. METHOD: Through an international consortium, the authors obtained DNA samples from 329 psychiatrically phenotyped subjects with 22q11.2DS. Using a high-resolution microarray platform and established methods to assess copy number variation (CNV), the authors compared the genome-wide burden of rare autosomal CNV, outside of the 22q11...
July 28, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28750156/psychiatric-conditions-as-predictors-of-rehospitalization-among-african-american-patients-hospitalized-with-heart-failure
#12
Marvin Louis Roy Lu, Toni Anne De Venecia, Abhinav Goyal, Mary Rodriguez Ziccardi, Napatt Kanjanahattakij, Mahek Kishor Shah, Carlos D Davila, Vincent M Figueredo
INTRODUCTION: African Americans (AAs) have the highest risk of developing heart failure (HF) among all ethnicities in the United States and are associated with higher rates of readmissions and mortality. This study aims to determine the prevalence and relationship of common psychiatric conditions to outcomes of patients hospitalized with HF. HYPOTHESIS: Psychiatric conditions lead to worse outcomes in HF patients. METHODS: This single-center retrospective study enrolled 611 AA patients admitted to an urban teaching community hospital for HF from 2010 to 2013...
July 27, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28749830/characteristics-of-patients-involved-in-physical-assault-in-an-acute-inpatient-psychiatric-setting
#13
Sohag N Sanghani, Akeem N Marsh, Majnu John, Arya Soman, Leonardo V Lopez, Yolana A Young, Mark J Russ
BACKGROUND: Although aggressive behavior in psychiatric settings is a major concern, very few studies have focused exclusively on physical assault in a general inpatient psychiatric population. OBJECTIVES: This study had 3 main goals: (1) to evaluate the prevalence of assaultive behavior in an acute psychiatric hospital; (2) to identify the clinical and socio-demographic factors associated with assaultive behavior during hospitalization; and (3) to explore whether a diagnosis of schizophrenia spectrum disorder increases the risk of assaultive behavior...
July 2017: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/28738196/parental-age-and-the-risk-of-obsessive-compulsive-disorder-and-tourette-syndrome-chronic-tic-disorder-in-a-nationwide-population-based-sample
#14
Roshan Chudal, Susanna Leivonen, Hanna Rintala, Susanna Hinkka-Yli-Salomäki, Andre Sourander
OBJECTIVES: Advancing paternal age has been associated with several neuropsychiatric disorders in children. However, there is limited understanding of this association with obsessive compulsive disorder (OCD) and Tourette syndrome/chronic tic disorder (TS/CT) with inconsistent findings. We examined the association between parental age and offspring OCD and TS/CT. METHODS: This nested case-control study used the Finnish Hospital Discharge Register (FHDR) to identify 1358 individuals with OCD and 1195 with TS/CT, born from 1991 to 2009 and diagnosed by 2010...
July 18, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28734239/stigma-resistance-and-its-association-with-internalised-stigma-and-psychosocial-outcomes-among-psychiatric-outpatients
#15
Ying Wen Lau, Louisa Picco, Shirlene Pang, Anitha Jeyagurunathan, Pratika Satghare, Siow Ann Chong, Mythily Subramaniam
Studies have suggested that stigma resistance plays an important role in the recovery from mental illness. However, there has been limited research in Asian countries that has examined the benefits of stigma resistance among the mentally ill in Asian populations. Hence, this study aimed to assess the prevalence of stigma resistance and establish the socio-demographic correlates of stigma resistance, as well as its association with internalised stigma and psychosocial outcomes among a multi-ethnic population of 280 outpatients with obsessive compulsive disorder (OCD), schizophrenia, depressive disorders and anxiety disorders in Singapore...
July 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28734096/association-of-toxoplasma-gondii-infection-with-schizophrenia-and-its-relationship-with-suicide-attempts-in-these-patients
#16
Maryam Ansari-Lari, Hassan Farashbandi, Fahimeh Mohammadi
OBJECTIVES: To investigate the association between schizophrenia and Toxoplasma gondii, and to assess the association of infection with suicide attempts and age of onset of schizophrenia in these patients. METHODS: Case-control study Fars Province, southern Iran. Cases were individuals with psychiatric diagnosis of schizophrenia as per Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. Controls were healthy blood donors, frequency-matched with patients according to age and sex...
July 22, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28716128/tobacco-dependence-among-people-with-mental-illness-a-facility-based-cross-sectional-study-from-southwest-ethiopia
#17
Zemenay Molla, Lamesa Dube, Wolfgang Krahl, Matiwos Soboka
BACKGROUND: Tobacco smoking is a health care issue in developed as well as in developing countries. Tobacco smoking among people with mental illness is significantly higher than in the general population. Tobacco smoking has negative effects on physical, mental and financial well-being of people with mental illness but little is known about tobacco dependence among mental health service users in sub-Saharan African countries, including Ethiopia. Therefore, this study attempted to assess the prevalence of tobacco dependence and associated factors among mental health service users at Jimma University teaching hospital...
July 17, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28697856/demographic-and-clinical-correlates-of-substance-use-disorders-in-first-episode-psychosis
#18
Mary F Brunette, Kim T Mueser, Steven Babbin, Piper Meyer-Kalos, Robert Rosenheck, Christoph U Correll, Corrine Cather, Delbert G Robinson, Nina R Schooler, David L Penn, Jean Addington, Sue E Estroff, Jennifer Gottlieb, Shirley M Glynn, Patricia Marcy, James Robinson, John M Kane
BACKGROUND: We assessed the prevalence and correlates of lifetime substance use disorders in people with first episode psychosis using the baseline data from the Recovery After an Initial Schizophrenia Episode (RAISE) Early Treatment Program study. METHODS: Research staff assessed 404 first episode patients at 34 community mental health centers across the United States with the Structured Clinical Interview for DSM-IV for diagnoses of psychotic and substance use disorders...
July 8, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28687481/prevalence-and-risk-factors-for-hiv-hepatitis-b-and-hepatitis-c-in-people-with-severe-mental-illness-a-total-population-study-of-sweden
#19
Clarissa Bauer-Staeb, Lena Jörgensen, Glyn Lewis, Christina Dalman, David P J Osborn, Joseph F Hayes
BACKGROUND: Severe mental illness is associated with increased morbidity and mortality. The elevated risk of blood-borne viruses (BBVs) in people with severe mental illness is of concern, but the full extent of this problem is unclear. We aimed to determine the prevalence of and risk factors for BBVs in people with severe mental illness. METHODS: In this nationwide, population-based, cross-sectional study, we estimated the point prevalence of HIV, hepatitis B (HBV), and hepatitis C (HCV) in people with severe mental illness, including the total adult (≥18 years) Swedish population...
September 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28651908/prevalence-demographic-and-clinical-features-of-comorbid-depressive-symptoms-in-drug-na%C3%A3-ve-patients-with-schizophrenia-presenting-with-first-episode-psychosis
#20
Jing Dai, Xiangdong Du, Guangzhong Yin, Yingyang Zhang, Haishen Xia, Xiaosi Li, Rylan Cassidy, Qingchun Tong, Dachun Chen, Antonio Lucio Teixeira, Yingjun Zheng, Yuping Ning, Jair C Soares, Man-Xi He, Xiang Yang Zhang
Depressive symptoms are common in first episode schizophrenia. However, the prevalence and its associations of comorbid depressive symptoms with clinical variables are less well characterized in Chinese Han patients with schizophrenia. In this cross-sectional study, we recruited 240 first-episode and drug naïve (FEDN) inpatients with schizophrenia. All patients were rated on the 17-item Hamilton Depression Rating Scale (HAMD-17) to measure depressive symptoms, and also on the Positive and Negative Syndrome Scale (PANSS) for psychopathology...
June 23, 2017: Schizophrenia Research
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