Cristina Müller, Aviral Singh, Christoph A Umbricht, Harshad R Kulkarni, Karl Johnston, Martina Benešová, Stefan Senftleben, Dirk Müller, Christiaan Vermeulen, Roger Schibli, Ulli Köster, Nicholas P van der Meulen, Richard P Baum
BACKGROUND: For almost a decade, terbium radioisotopes have been explored for their potential theragnostic application in nuclear medicine: 152 Tb and 155 Tb are the radioisotopes identified for PET or SPECT imaging, while 149 Tb and 161 Tb have suitable decay characteristics for α- and combined β- /Auger-e- -therapy, respectively. In the present study, the application of 152 Tb, in combination with PSMA-617 for imaging of prostate-specific membrane antigen (PSMA)-positive prostate cancer, was demonstrated in a preclinical setting and in a patient with metastatic castration-resistant prostate cancer (mCRPC)...
July 25, 2019: EJNMMI Research