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https://www.readbyqxmd.com/read/29313576/pharmacological-reperfusion-therapy-with-tenecteplase-in-7-668-indian-patients-with-st-elevation-myocardial-infarction-a-real-world-indian-experience
#1
S S Iyengar, Tiny Nair, Jagdish Hiremath, Anjan Lal Dutta, Uday Jadhav, V K Katyal, Dayanand Kumbla, Immaneni Sathyamurthy, R K Jain, M Srinivasan, Prasant Kr Sahoo
Objective: This real-world, observational, prescription event monitoring study was conducted to evaluate safety and efficacy of indigenous tenecteplase (TNK-tPA) in Indian patients presenting with ST elevation myocardial infarction (STEMI). Methods: This is a multi-centric, observational, prescription event monitoring study. Data was collected for 7,668 patients from 1,307 investigator sites across India from January 2011 to February 2016. Results: Overall, 76...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29281605/trends-in-cardiovascular-risk-profiles
#2
REVIEW
Samir Kapadia
Outcomes for patients with coronary artery disease (CAD) have improved in the past 20 years likely due to advances in clinical care such as angiotensin-converting enzyme inhibitors, antiplatelet agents, and reduced time to cardiac cauterization procedures. But how have the risk factors for CAD changed in the past 2 decades? Analysis of nearly 4,000 patients with ST-elevation myocardial infarction (STEMI) at a tertiary care center found that patients presenting with acute STEMI are younger and more obese than in the past...
December 2017: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29260713/correlates-of-non-target-vessel-related-adverse-events-in-patients-with-st-segment-elevation-myocardial-infarction-insights-from-5-year-follow-up-of-the-examination-trial
#3
Giosafat Spitaleri, Elisabetta Moscarella, Salvatore Brugaletta, Alberto Pernigotti, Luis Ortega-Paz, Josep Gomez-Lara, Angel Cequier, Andrés Íñiguez-Romo, Antonio Serra, Pilar Jiménez-Quevedo, Vicente Mainar, Gianluca Campo, Maurizio Tespili, Peter den Heijer, Armando Bethencourt, Nicolás Vazquez, Marco Valgimigli, Patrick W Serruys, Manel Sabaté
AIMS: to determine the 5-year correlates of non-TV related adverse events (AE) in STEMI patients included in the EXAMINATION trial. METHODS AND RESULTS: the EXAMINATION trial randomized 1498 STEMI patients to bare-metal or everolimus-eluting stent. In this sub-study, patients were analyzed according to non-TV related AE, defined as the composite of either non-TV revascularization (non-TVR) or non-TV related myocardial infarction (MI). At 5-year follow-up, 125 patients (8...
December 19, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29230597/presence-of-post-systolic-shortening-is-an-independent-predictor-of-heart-failure-in-patients-following-st-segment-elevation-myocardial-infarction
#4
Philip Brainin, Sune Haahr-Pedersen, Morten Sengeløv, Flemming Javier Olsen, Thomas Fritz-Hansen, Jan Skov Jensen, Tor Biering-Sørensen
Following an ischemic event post systolic shortening (PSS) may occur. We investigated the association between PSS in patients with ST-segment elevation myocardial infarction (STEMI) following primary percutaneous coronary intervention (pPCI) and occurrence of cardiovascular events at follow-up. A total of 373 patients admitted with STEMI and treated with pPCI were prospectively included in the study cohort. All patients were examined by echocardiography a median of 2 days after admission (interquartile range, 1-3 days)...
December 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29223429/predicting-risk-of-cardiac-events-among-st-segment-elevation-myocardial-infarction-patients-with-conservatively-managed-non-infarct-related-artery-coronary-artery-disease-an-analysis-of-the-duke-databank-for-cardiovascular-disease
#5
RANDOMIZED CONTROLLED TRIAL
Sameer A Hirji, Susanna R Stevens, Linda K Shaw, Erin C Campbell, Christopher B Granger, Manesh R Patel, Michael H Sketch, Tracy Y Wang, E Magnus Ohman, Eric D Peterson, J Matthew Brennan
BACKGROUND: Recent randomized evidence has demonstrated benefit with complete revascularization during the index hospitalization for multivessel coronary artery disease ST-segment elevation myocardial infarction (STEMI) patients; however, this benefit likely depends on the risk of future major adverse cardiovascular events (MACE). METHODS: Using data from Duke University Medical Center (2003-2012), we identified those at high risk for 1-year MACE among 664 STEMI patients with conservatively managed non-infarct-related artery (non-IRA) lesions...
December 2017: American Heart Journal
https://www.readbyqxmd.com/read/29208886/coronary-angiography-findings-and-its-determinants-in-patients-presenting-with-acute-coronary-syndrome-a-descriptive-analysis-from-asian-population
#6
M Chourasiya, S Satheesh, R Selvaraj, B Jayaraman, A A Pillai
The aim was to study the angiographic profile in patients presented as acute coronary syndrome and its relation with risk factors and comparison between genders. This prospective observational study was performed on total 352 patients of acute coronary syndrome were analyzed for various risk factors, angiographic pattern in Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, South India from January 2015 to July 2016. Mean age of presentation was 52.62±11.63 years. Male were 271(77...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29189830/-ambulatory-cardiac-rehabilitation-in-trieste-protocols-of-intervention-activities-and-outcomes
#7
Sara Doimo, Patrizia Maras, Giulia Barbati, Enrico Fabris, Alessio Della Mattia, Kareem Salame, Giuseppe Gatti, Gianfranco Sinagra
BACKGROUND: Cardiac rehabilitation (CR) is a model of care proven to reduce mortality and morbidity in patients with coronary artery disease. The aim of this study is to describe the ambulatory CR model of the Cardiovascular Department of Trieste (Italy), analyzing the outcome of the population. METHODS: We analyzed clinical and instrumental characteristics of all consecutive patients after ST-elevation myocardial infarction (STEMI), non-ST-elevation myocardial infarction (NSTEMI), coronary artery bypass graft with or without valve surgery (CABG/CABGV), or planned percutaneous coronary intervention (PCI), referred for CR from January 1, 2009, to December 31, 2015...
December 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/29178978/the-association-between-exposure-to-air-pollutants-including-pm10-pm2-5-ozone-carbon-monoxide-sulfur-dioxide-and-nitrogen-dioxide-concentration-and-the-relative-risk-of-developing-stemi-a-case-crossover-design
#8
Mohammad Ali Akbarzadeh, Isa Khaheshi, Amirsina Sharifi, Negin Yousefi, Mohammadreza Naderian, Mohammad Hasan Namazi, Morteza Safi, Hossein Vakili, Habibollah Saadat, Saeed Alipour Parsa, Negin Nickdoost
BACKGROUND: Unfavorable associations between air pollution and myocardial infarction are broadly investigated in recent studies and some of them revealed considerable associations; however, controversies exists between these investigations with regard to culprit components of air pollution and significance of correlation between myocardial infarction risk and air pollution. METHODS: The association between exposure to PM10, PM2.5, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide concentration of background air that residents of Tehran, the capital city of Iran, which is ranked as the most air polluted city of Iran and the relative risk of developing ST-elevation myocardial infarction (STEMI) were investigated by a case-crossover design...
November 24, 2017: Environmental Research
https://www.readbyqxmd.com/read/29153575/persistent-iron-within-the-infarct-core%C3%A2-after-st-segment-elevation-myocardial-infarction-implications-for-left-ventricular-remodeling-and-health%C3%A2-outcomes
#9
Jaclyn Carberry, David Carrick, Caroline Haig, Nadeem Ahmed, Ify Mordi, Margaret McEntegart, Mark C Petrie, Hany Eteiba, Stuart Hood, Stuart Watkins, Mitchell Lindsay, Andrew Davie, Ahmed Mahrous, Ian Ford, Naveed Sattar, Paul Welsh, Aleksandra Radjenovic, Keith G Oldroyd, Colin Berry
OBJECTIVES: This study sought to determine the incidence and prognostic significance of persistent iron in patients post-ST-segment elevation myocardial infarction (STEMI). BACKGROUND: The clinical significance of persistent iron within the infarct core after STEMI complicated by acute myocardial hemorrhage is poorly understood. METHODS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI [Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction])...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29141503/association-of-the-genetic-and-traditional-risk-factors-of-ischaemic-heart-disease-with-stemi-and-nstemi-development
#10
Diana Žaliaduonytė-Pekšienė, Vaiva Lesauskaitė, Rasa Liutkevičienė, Vytenis Tamakauskas, Vilius Kviesulaitis, Giedrė Šinkūnaitė-Maršalkienė, Sandrita Šimonytė, Simonita Mačiulskytė, Eglė Tamulevičiūtė-Prascienė, Olivija Gustienė, Abdonas Tamošiūnas, Remigijus Žaliūnas
INTRODUCTION: To evaluate the influence of traditional risk factors of ischaemic heart disease and genetic factors to predict different types of acute coronary syndromes. MATERIALS AND METHODS: Five hundred and twenty-three patients with acute coronary syndromes (393 with ST elevation myocardial infarction (STEMI) and 130 with non-ST elevation myocardial infarction (NSTEMI)) comprised the study group. The control group consisted of 645 subjects free from symptoms of ischaemic heart disease and stroke...
October 2017: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/28983170/analysis-of-risk-factors-presentation-and-in-hospital-events-of-very-young-patients-presenting-with-st-elevation-myocardial-infarction
#11
Edward L Callachan, Alawi A Alsheikh-Ali, Lee A Wallis
INTRODUCTION: In the Indian subcontinent and Arab Gulf, coronary artery disease is affecting younger persons at greater rates. Few studies have focused on young ST-elevation myocardial infarction (STEMI) patients in these regions. We examine the clinical profile and treatment of STEMI patients aged <40 years. METHODS: Participants consisted of 77 STEMI patients, aged <40 years, admitted to hospitals in Abu Dhabi. Data were collected using electronic medical records...
October 2017: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/28974830/experience-and-outcomes-of-primary-percutaneous-coronary-intervention-for-patients-with-st-segment-elevation-myocardial-infarction-of-tertiary-care-center-in-bosnia-and-herzegovina
#12
Elmir Jahic
BACKGROUND: Primary percutaneous coronary intervention (PCI) is an emergent percutaneous catheter intervention in the setting of ST-segment elevations myocardial infarction (STEMI), without previous fibrinolytic treatment. AIM: To evaluate the feasibility and outcomes of primary percutaneous coronary interventions for STEMI in regional tertiary care cardiac centre in Bosnia and Herzegovina. METHODS: Between January 2014 and December 2016, consecutive 549 STEMI patients who underwent primary PCI were prospectively enrolled in a primary PCI registry...
June 2017: Medical Archives
https://www.readbyqxmd.com/read/28927394/laboratory-markers-of-cardiac-and-metabolic-complications-after-generalized-tonic-clonic-seizures
#13
Robert D Nass, Sina Meiling, René P Andrié, Christian E Elger, Rainer Surges
BACKGROUND: Generalized tonic-clonic seizures (GTCS) frequently lead to emergency inpatient referrals. Laboratory blood values are routinely performed on admission to detect underlying causes and metabolic or cardiac complications. Our goal was to assess the nature and frequency of complications occurring in association with GTCS. METHODS: We retrospectively extracted data from emergency protocols and discharge letters of adult patients admitted to the Department of Epileptology between 01/2010 and 06/2015...
September 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28889210/ketamine-and-midazolam-differently-impact-post-intubation-hemodynamic-profile-when-used-as-induction-agents-during-emergency-airway-management-in-hemodynamically-stable-patients-with-st-elevation-myocardial-infarction
#14
Marco Zuin, Gianluca Rigatelli, Fabio Dell'Avvocata, Giuseppe Faggian, Luca Conte, Sara Giatti, Flavio Michielan, Loris Roncon
We investigated the incidence of post-intubation hypotension (PIH) in hemodynamically stable patients with STEMI requiring rapid sequences intubation (RSI) and medicated with ketamine or midazolam as induction agent. STEMI patients admitted between 1st January 2009 and 1st January 2017 who did not receive any type of inotropic support before the endotracheal intubation (ETI) was reviewed. PIH was defined as a reduction greater than 20% or a drop of systolic blood pressure (SBP) below 90 mmHg within 10 min from the administration of the induction agent [ketamine (1 mg/kg) or midazolam (0...
September 9, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28888267/sex-based-differences-in-quality-of-care-and-outcomes-in-a-health-system-using-a-standardized-stemi-protocol
#15
MULTICENTER STUDY
Janet Wei, Puja K Mehta, Elizabeth Grey, Ross F Garberich, Robert Hauser, C Noel Bairey Merz, Timothy D Henry
BACKGROUND: Recent data from the National Cardiovascular Data Registry indicate that women with ST-segment-elevation myocardial infarction (STEMI) continue to have higher mortality and reported delays in treatment compared with men. We aimed to determine whether the sex difference in mortality exists when treatment disparities are reduced. METHODS: Using a prospective regional percutaneous coronary intervention (PCI)-based STEMI system database with a standardized STEMI protocol, we evaluated baseline characteristics, treatment, and clinical outcomes of STEMI patients stratified by sex...
September 2017: American Heart Journal
https://www.readbyqxmd.com/read/28883734/prognostic-impact-of-blood-pressure-and-heart-rate-at-admission-on-in-hospital-mortality-after-primary-percutaneous-intervention-for-acute-myocardial-infarction-with-st-segment-elevation-in-western-romania
#16
Diana Aurora Bordejevic, Florina Caruntu, Cristian Mornos, Ioan Olariu, Lucian Petrescu, Mirela Cleopatra Tomescu, Ioana Citu, Adelina Mavrea, Sorin Pescariu
BACKGROUND: The purpose of this retrospective study was to evaluate the prognostic impact of systolic blood pressure (SBP) and heart rate (HR) on in-hospital mortality in ST-segment elevation acute myocardial infarction (STEMI) patients, after primary percutaneous intervention (PCI). PATIENTS AND METHODS: The study included 294 patients admitted for STEMI. They were divided into five groups according to the SBP at admission: group I, <105 mmHg; group II, 105-125 mmHg; group III, 126-140 mmHg; group IV, 141-158 mmHg; and group V, ≥159 mmHg...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28864322/impact-of-body-mass-index-on-5-year-clinical-outcomes-in-patients-with-st-segment-elevation-myocardial-infarction-after-everolimus-eluting-or-bare-metal-stent-implantation
#17
RANDOMIZED CONTROLLED TRIAL
Elisabetta Moscarella, Giosafat Spitaleri, Salvatore Brugaletta, Sara Sentí Farrarons, Alberto Pernigotti, Luis Ortega-Paz, Angel Cequier, Andrés Iñiguez, Antonio Serra, Pilar Jiménez-Quevedo, Vicente Mainar, Gianluca Campo, Maurizio Tespili, Peter den Heijer, Armando Bethencourt, Nicolás Vazquez, Marco Valgimigli, Patrick W Serruys, Manel Sabaté
Patients with high body mass index (BMI) seem to have better outcomes after percutaneous coronary intervention than normal-weight patients. However, contrasting results have been reported on the "obesity paradox" in patients presenting with ST-elevation myocardial infarction (STEMI). The aim of our study was to investigate the impact of BMI on mortality in the population enrolled in the Evaluation of the Xience-V stent in Acute Myocardial INfArcTION (EXAMINATION) trial. The EXAMINATION trial randomized 1,498 patients with STEMI to a bare-metal stent or an everolimus-eluting stent...
November 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28844989/acute-myocardial-infarction-changes-in-patient-characteristics-management-and-6-month-outcomes-over-a-period-of-20-years-in-the-fast-mi-program-french-registry-of-acute-st-elevation-or-non-st-elevation-myocardial-infarction-1995-to-2015
#18
Etienne Puymirat, Tabassome Simon, Guillaume Cayla, Yves Cottin, Meyer Elbaz, Pierre Coste, Gilles Lemesle, Pascal Motreff, Batric Popovic, Khalife Khalife, Jean Noel Labeque, Thibault Perret, Christophe Le Ray, Laurent Orion, Bernard Jouve, Didier Blanchard, Patrick Peycher, Johanne Silvain, P Gabriel Steg, Patrick Goldstein, Pascal J Gueret, Loic Belle, Nadia Aissaoui, Jean Ferrières, Francois Schiele, Nicolas Danchin
Background -ST-segment-elevation myocardial infarction (STEMI) and non-ST-segment-elevation myocardial infarction (NSTEMI) management has evolved considerably over the past 2 decades. Little information on mortality trends in the most recent years is available. We assessed trends in characteristics, treatments, and outcomes for acute myocardial infarction in France between 1995 and 2015. Methods - We used data from 5 one-month registries, conducted 5 years apart, from 1995 to 2015, including 14 423 patients with acute myocardial infarction (59% STEMI) admitted to cardiac intensive care units in metropolitan France...
August 27, 2017: Circulation
https://www.readbyqxmd.com/read/28838603/effect-of-shorter-door-to-balloon-times-over-20-years-on-outcomes-of-patients-with-anterior-st-elevation-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#19
Amgad Mentias, Mohammad Q Raza, Amr F Barakat, Dalia Youssef, Russell Raymond, Venu Menon, Conrad Simpfendorfer, Irving Franco, Stephen Ellis, E Murat Tuzcu, Samir R Kapadia
Cardiovascular disease remains the most common cause of mortality. We studied the change in outcomes for anterior ST-elevation myocardial infarction (STEMI) between 1995 and 2014. Over the past 20 years, 1,658 patients presenting to our center with anterior STEMI underwent primary percutaneous coronary intervention within 12 hours of presentation. We divided these into 4 quartiles, 1995 to 1999 (n = 312), 2000 to 2004 (n = 408), 2005 to 2009 (n = 428), and 2010 to 2014 (n = 510). Across the 4 quartiles, mean age decreased (64...
October 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28836016/impact-of-age-on-short-and-long-term-mortality-of-patients-with-st-elevation-myocardial-infarction-in-the-vienna-stemi-network
#20
Paul Michael Haller, Bernhard Jäger, Serdar Farhan, Günter Christ, Wolfgang Schreiber, Franz Weidinger, Thomas Stefenelli, Georg Delle-Karth, Alfred Kaff, Gerald Maurer, Kurt Huber
BACKGROUND AND AIM: Our senescent society includes a growing number of elderly people suffering from ST-elevation myocardial infarction (STEMI); however, exactly this population is often underrepresented in randomized trials. Hence, our aim was to investigate the influence of age on patient characteristics, as well as short- and long-term outcome in the Vienna STEMI registry. METHODS: We included all patients of the Vienna STEMI registry (2003-2009). Patients were stratified into age cohorts (≤45, 46-59, 60-79 and ≥80 years, respectively)...
August 23, 2017: Wiener Klinische Wochenschrift
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