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https://www.readbyqxmd.com/read/28724257/efficient-coproduction-of-gluconic-acid-and-xylonic-acid-from-lignocellulosic-hydrolysate-by-zn-ii-selective-inhibition-on-whole-cell-catalysis-by-gluconobacter-oxydans
#1
Xuelian Zhou, Xin Zhou, Lu Huang, Rou Cao, Yong Xu
With Zn(II)-selective inhibition on the whole-cell catalysis of Gluconobacter oxydans NL71, gluconic acid and xylonic acid were coproduced efficiently from the hydrolysate of corn stover. Further metabolism of gluconic acid to the by-product 2-ketogluconic acid was prevented by addition of 10g/L ZnCl2. Remarkably, yields of 93.91% of gluconic acid and 93.36% of xylonic acid were obtained with the supplement of ZnCl2 in the synthetic medium, without by-product production. After optimization of the concentrations of ZnCl2 and inocula of the strain, maximum amounts of gluconic acid and xylonic acid were coproduced at titers of 63...
July 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28724254/effects-of-calcium-on-the-performance-bacterial-population-and-microbial-metabolism-of-a-denitrifying-phosphorus-removal-system
#2
Hongliang Dai, Yifeng Wu, Lihong Peng, Zheqin Dai, Xiang Li, Xiwu Lu
A sequencing batch reactor was operated to study the effects of influent Ca(2+) on the efficiency, bacterial population, and microbial metabolism of denitrifying phosphorus removal system. Results showed that high Ca(2+) loading (≥80mg/L) significantly inhibited the performance of simultaneous nitrogen and phosphorus removal. The abundance of phosphorus removal-related organisms (Dechloromonas and Candidatus Accumulibacter) decreased with increasing Ca(2+) concentration from 20 to 140mg/L, while the abundance of glycogen-accumulating organisms and other bacteria increased...
July 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28724251/concurrent-exposures-to-nonylphenol-bisphenol-a-phthalates-and-organophosphate-pesticides-on-birth-outcomes-a-cohort-study-in-taipei-taiwan
#3
Yu-Fang Huang, Wen-Chi Pan, Yen-An Tsai, Chia-Huang Chang, Pei-Jung Chen, Yi-Shuan Shao, Ming-Song Tsai, Jia-Woei Hou, Chensheng Alex Lu, Mei-Lien Chen
Prenatal exposure to phenols, phthalates (PAEs), and organophosphate (OP) pesticides may increase the risk of abnormal birth outcomes. However, many previous studies have examined exposure to a limited number of chemical classes or exposure profiles limited to a specific stage of pregnancy. This study aims to characterize the concurrent exposure scenario throughout pregnancy by simultaneously monitoring internal doses of several endocrine-disrupting compounds (EDCs), including 2 phenols (nonylphenol (NP) and bisphenol A (BPA)), 9 PAEs, and 6 OP pesticide metabolites and to assess the relationships between concurrent exposure to EDCs and infant birth weight, length, and head and chest circumference...
July 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28724215/melatonin-inhibits-proliferation-and-invasion-via-repression-of-mirna-155-in-glioma-cells
#4
Junyi Gu, Zhongsheng Lu, Chenghong Ji, Yuchao Chen, Yuzhao Liu, Zhe Lei, Longqiang Wang, Hong-Tao Zhang, Xiangdong Li
Melatonin, an indolamine mostly synthesized in the pineal gland, exerts the anti-cancer effect by various mechanisms in glioma cells. Our previous study showed that miR-155 promoted glioma cell proliferation and invasion. However, the question of whether melatonin may inhibit glioma by regulating miRNAs has not yet been addressed. In this study, we found that melatonin (100μM, 1μM and 1nM) significantly inhibited the expression of miR-155 in human glioma cell lines U87, U373 and U251. Especially, the lowest expression of miR-155 was detected in 1μM melatonin-treated glioma cells...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28724133/a-nationwide-analysis-of-cost-variation-for-autologous-free-flap-breast-reconstruction
#5
Jessica I Billig, Yiwen Lu, Adeyiza O Momoh, Kevin C Chung
Importance: Cost variation among hospitals has been demonstrated for surgical procedures. Uncovering these differences has helped guide measures taken to reduce health care spending. To date, the fiscal consequence of hospital variation for autologous free flap breast reconstruction is unknown. Objective: To investigate factors that influence cost variation for autologous free flap breast reconstruction. Design, Setting, and Participants: A secondary cross-sectional analysis was performed using the Healthcare Cost and Utilization Project National Inpatient Sample database from 2008 to 2010...
July 19, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28724091/effect-of-environmental-conditions-on-the-degradation-of-florasulam-in-typical-soils-of-northern-china
#6
Wangcang Su, Hongle Xu, Hongdan Hao, Renhai Wu, Hengliang Wang, Chuantao Lu
The widespread use of florasulam in China makes residues from this herbicide in soil a serious concern due to their potential to pollute the soil environment and groundwater. Accelerating the degradation of these residues will reduce their pollution potential. In this study, we investigated the degradation and adsorption of florasulam in four typical soils in northern China and examined the degradation of florasulam in Inceptisols at different temperatures, soil moisture contents, and pH values, as well as the influence of microorganisms and the use of organic matter and biogas slurry as soil amendments...
May 2017: Journal of Environmental Quality
https://www.readbyqxmd.com/read/28723926/ghsos1-a-plasma-membrane-na-h-antiporter-gene-from-upland-cotton-enhances-salt-tolerance-in-transgenic-arabidopsis-thaliana
#7
Xiugui Chen, Xuke Lu, Na Shu, Delong Wang, Shuai Wang, Junjuan Wang, Lixue Guo, Xiaoning Guo, Weili Fan, Zhongxu Lin, Wuwei Ye
Upland cotton (Gossypium hirsutum L.), an important source of natural fiber, can tolerate relatively high salinity and drought stresses. In the present study, a plasma membrane Na+/H+ antiporter gene, GhSOS1, was cloned from a salt-tolerant genotype of G. hirsutum, Zhong 9807. The expression level of GhSOS1 in cotton roots was significantly upregulated in the presence of high concentrations of NaCl (200 mM), while its transcript abundance was increased when exposed to low temperature and drought stresses. Localization analysis using onion epidermal cells showed that the GhSOS1 protein was localized to the plasma membrane...
2017: PloS One
https://www.readbyqxmd.com/read/28723896/maternal-h3k27me3-controls-dna-methylation-independent-imprinting
#8
Azusa Inoue, Lan Jiang, Falong Lu, Tsukasa Suzuki, Yi Zhang
Mammalian sperm and oocytes have different epigenetic landscapes and are organized in different fashions. After fertilization, the initially distinct parental epigenomes become largely equalized with the exception of certain loci, including imprinting control regions. How parental chromatin becomes equalized and how imprinting control regions escape from this reprogramming is largely unknown. Here we profile parental allele-specific DNase I hypersensitive sites in mouse zygotes and morula embryos, and investigate the epigenetic mechanisms underlying these allelic sites...
July 19, 2017: Nature
https://www.readbyqxmd.com/read/28723792/concomitant-stromal-tumor-and-early-cancer-of-the-stomach-what-should-be-done
#9
Yan Xu, Liangfang Shen, Zhaoxia Lu, Xiaowei Liu, Wei Wu, Deyun Feng, Jaladanki N Rao, Lan Xiao, Miao Ouyang
Concomitant gastric stromal tumor (GST) and gastric cancer (GC) is uncommon; even more uncommon is a concomitant GST and early stage GC (EGC). Tumor resection by endoscopic submucosal dissection (ESD) for concomitant GST and EGC has not been reported. We sought to define the clinical importance of detection of concomitant GST and EGC during the first esophagogastroduodenoscopy (EGD), and compare the clinical outcomes of ESD versus radical surgery for the treatment of concomitant GST and EGC. Our investigation was a retrospective cohort study...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723766/lady-with-wings-a-case-report-of-giant-neurofibromatosis-type-i
#10
Suraj Maharjan, Xiucun Li, Jianli Cui, Yang Liu, Laijin Lu
RATIONALE: Neurofibromatosis type I (NF-I) accounts for approximately 90% of neurofibromatosis. NF-I is an autosomal dominant genetic disease which results from the gene mutation of NF-I situated in chromosome 17q11.2. PATIENT CONCERNS: A 32-year-old lady presented with a giant wing like structure on her back which started growing from her childhood. DIAGNOSIS: A diagnosis of NF-I was confirmed as she presented with multiple cutaneous nodules, multiple café-au-lait macules of different sizes, scoliosis deformity, and positive family history of neurofibroma...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723696/advanced-glycation-end-products-downregulate-hoxa9ec-through-activation-of-nuclear-factor-kappa-b-by-reciprocal-interaction
#11
Qian-Qian Zhu, Dong-Lin Li, Yang-Yan He, Zi-Heng Wu, Lu Tian, Cheng-Fei Zheng, Nan Zhang, Hong-Kun Zhang
Advanced glycation end-products (AGEs) have been recognized as an important pathophysiological mechanism in endothelial dysfunction during diabetic atherogenesis. Homeobox (Hox) genes have been identified as playing a regulatory role in the adult cardiovascular system. Regulation of HoxA9EC is involved in diabetic endothelial dysfunction, but the mechanism of HoxA9EC regulation has remained undefined. Here, we sought to investigate how HoxA9EC is regulated in AGE-induced endothelial dysfunction and to explore the mechanism involved...
July 20, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28723671/qishenyiqi-pill-attenuates-atherosclerosis-by-promoting-regulatory-t-cells-inhibiting-t-helper-17-cells-and-accelerating-cholesterol-excretion
#12
Li Peng, Chong-Shan Lv, Yun Zhao, Shao-Dong Chen, Yang Huang, Da-Wei Lu, Shu-Qiong Huang, Zong-Bao Yang, Lin-Chao Qian, Lei Wen
OBJECTIVE: The aim of this study was to explore potential immunoregulatory mechanisms underlying the suppressive effect on atherosclerosis of QiShenYiQi pill (QSYQ). METHODS AND RESULTS: Male ApoE-/- mice were maintained on a Western-type diet and QSYQ treatment for eight weeks. Determination of atherosclerosis demonstrated that QSYQ attenuated plaque formation and decreased the level of blood low-density lipoproteins-cholesterol. QSYQ treatment did not affect body weight but reduced the ratio of liver weight and body weight...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723662/acetyl-lupeolic-acid-inhibits-akt-signaling-and-induces-apoptosis-in-chemoresistant-prostate-cancer-cells-in-vitro-and-in-vivo
#13
Claudia Schmidt, Cornelia Loos, Lu Jin, Michael Schmiech, Christoph Q Schmidt, Menna El Gaafary, Tatiana Syrovets, Thomas Simmet
The triterpenoid acetyl-lupeolic acid (ac-LA) isolated from the oleogum resin of Boswellia carterii reduced the viability of a panel of cancer cell lines more efficiently than lupeol. There was no detectable intracellular conversion of ac-LA to lupeol and vice versa. In contrast to docetaxel, ac-LA did not induce selection of treatment-resistant cancer cells. By various parameters including DNA fragmentation, ac-LA was shown to induce apoptosis in androgen-independent PC-3 cells, whereas in MDA-MB-231 breast cancer cells, ac-LA led to cell accumulation in the G2/M phase of the cell cycle, but not to apoptosis...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723654/disrupted-small-world-brain-network-topology-in-pure-conduct-disorder
#14
Feng-Mei Lu, Jian-Song Zhou, Jiang Zhang, Xiao-Ping Wang, Zhen Yuan
OBJECTIVES: Conduct disorder (CD) is characterized by the violation of the rights of others or basic social rules and a repetitive, persistent pattern of antisocial and aggressive behaviors. A large number of functional and structural neuroimaging studies have identified widely abnormalities in specific brain regions in CD, but the alterations in the topological organization of functional networks among them remain largely unknown. METHODS: Resting-state functional magnetic resonance imaging was applied to investigate the intrinsic functional connectivity in 18 pure CD patients and eighteen typically developing healthy controls...
July 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723624/lncrna-ancr-down-regulation-promotes-tgf-%C3%AE-induced-emt-and-metastasis-in-breast-cancer
#15
Zhongwei Li, Meichen Dong, Dongmei Fan, Pingfu Hou, Hongyuan Li, Lingxia Liu, Cong Lin, Jiwei Liu, Liangping Su, Lan Wu, Xiaoxue Li, Baiqu Huang, Jun Lu, Yu Zhang
Epithelial to mesenchymal transition (EMT) is a progression of cellular plasticity critical for development, differentiation, cancer cells migration and tumor metastasis. As a well-studied factor, TGF-β participates in EMT and involves in physiological and pathological functions of tumor progression. Accumulating evidence indicates that long noncoding RNAs(lncRNAs) play crucial roles in EMT and tumor metastasis. Here, we find that lncRNA ANCR participates in TGF-β1-induced EMT. By our ChIP and Real-time PCR assays, we reveal that TGF-β1 down-regulates ANCR expression by increasing HDAC3 enrichment at ANCR promoter region, which decreases both H3 and H4 acetylation of ANCR promoter...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28723598/effects-of-tumor-necrosis-factor-blocker-on-salicylate-induced-tinnitus-in-mice
#16
Juen-Haur Hwang, David Chang-Wei Huang, Yin-Chang Lu, Wei-Shiung Yang, Tien-Chen Liu
OBJECTIVE: Neuroinflammation is considered a novel mechanism for acute tinnitus. Here, we investigated the effects of a tumor necrosis factor (TNF) blocker on the gene expression of inflammatory-cytokine in the cochlea in a tinnitus animal model. METHODS: Enbrel® (30 mg/kg, intraperitoneally (i.p.)) were administrated to the mice with the salicylate induced tinnitus for 3 days. Tinnitus score and mRNA expression levels of TNFR1, TNFR2, and N-methyl-d-aspartate receptor subunit 2B (NR2B) and its downstream regulatory element antagonist modulator (DREAM) in the cochlea of mice were measured and compared to the control...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28723567/cold-inducible-sirt6-regulates-thermogenesis-of-brown-and-beige-fat
#17
Lu Yao, Xiaona Cui, Qi Chen, Xiaoying Yang, Fude Fang, Jun Zhang, Guoqing Liu, Wanzhu Jin, Yongsheng Chang
Promoting development and function of brown and beige fat may reduce obesity. Here, we show that fat SIRT6 expression is markedly induced by cold exposure and a β-adrenergic agonist. Deletion of SIRT6 in adipose tissue impairs the thermogenic function of brown adipocytes, causing a morphological "whitening" of brown fat, reduced oxygen (O2) consumption, obesity, decreased core body temperature, and cold sensitivity. Fat SIRT6-deleted mice exhibit increased blood glucose levels, severe insulin resistance, and hepatic steatosis...
July 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28723328/artemisinin-resistant-plasmodium-falciparum-in-africa
#18
Feng Lu, Richard Culleton, Jun Cao
No abstract text is available yet for this article.
July 20, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28723311/visual-perceptual-learning-and-models
#19
Barbara Dosher, Zhong-Lin Lu
Visual perceptual learning through practice or training can significantly improve performance on visual tasks. Originally seen as a manifestation of plasticity in the primary visual cortex, perceptual learning is more readily understood as improvements in the function of brain networks that integrate processes, including sensory representations, decision, attention, and reward, and balance plasticity with system stability. This review considers the primary phenomena of perceptual learning, theories of perceptual learning, and perceptual learning's effect on signal and noise in visual processing and decision...
July 19, 2017: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28723194/aromatization-of-9-10-dihydroacridine-derivatives-discovering-a-highly-selective-and-rapid-responding-fluorescent-probe-for-peroxynitrite
#20
Zhi-Heng Li, Rui Liu, Zheng-Li Tan, Lan He, Zhong-Lin Lu, Bing Gong
As part of an effort to develop generally applicable strategies for creating probes suitable for detecting important molecular and ionic species, the oxidative aromatization of nonfluorescent 9,10-dihydroacridine derivatives triggered by peroxynitrite (ONOO(-)) led to the identification of compound 2H, 9-phenyl-9,10-dihydroacridine-4-carboxylic acid, as a rapid-responding fluorescent probe capable of detecting ONOO(-) with an extraordinary selectivity. Adding a little more than 1 equiv of ONOO(-) to a solution of 2H resulted in over 100-fold fluorescence enhancement...
April 28, 2017: ACS Sensors
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