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Occupational lung disease

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https://www.readbyqxmd.com/read/28339739/unabated-occupational-risk-in-a-patient-with-rheumatoid-pulmonary-fibrosis
#1
V K Holden, S J Kligerman, T G Hastings, S E Hines
Background: This case highlights the importance of considering hypersensitivity pneumonitis (HP) in the differential diagnosis of interstitial lung disease (ILD) and of obtaining an occupational history so that remediable risk factors may be identified and managed. Aims: To report a case of a chicken sexer with severe rheumatoid arthritis (RA) who developed progressively worsening dyspnoea and restrictive lung disease associated with pulmonary fibrosis. Methods: Clinical investigation included physical examination, occupational history, pulmonary function tests (PFTs), chest imaging and bronchoalveolar lavage (BAL), as well as serological tests including standard IgE bird feather mixture and local IgG precipitin preparation to chicken excrement...
February 23, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/28326180/are-physicians-in-primary-health-care-able-to-recognize-pulmonary-fibrosis
#2
Minna Purokivi, Ulla Hodgson, Marjukka Myllärniemi, Eija-Riitta Salomaa, Riitta Kaarteenaho
Background: The early diagnosis of idiopathic pulmonary fibrosis (IPF) has become increasingly important due to evolving treatment options. IPF patients experience a significant delay in receiving an accurate diagnosis, thus delayed access to tertiary care is associated with higher mortality independently from disease severity. Objective: The aims were to evaluate whether there had been a delay in the referral process, and to determine whether the referring doctors had suspected IPF or other interstitial lung disease (ILD) already during the time of referral...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28326173/a-systematic-review-of-occupational-exposure-to-coal-dust-and-the-risk-of-interstitial-lung-diseases
#3
REVIEW
Christiane Beer, Henrik A Kolstad, Klaus Søndergaard, Elisabeth Bendstrup, Dick Heederik, Karen E Olsen, Øyvind Omland, Edward Petsonk, Torben Sigsgaard, David L Sherson, Vivi Schlünssen
Objective: Exposure to coal dust can cause interstitial lung disease (ILD), but whether this is due to pure coal or to the contents of quartz in coal is less clear. Here, we systematically reviewed the relation between 'pure coal' and ILD. Methods: In a systematic review based on PRISMA criteria 2945 articles were identified. Strict eligibility criteria, which evaluated the 'pure coal effect', led to the inclusion of only nine studies. Results: Among these nine studies six studies indicated an independent effect of the non-quartz part of coal on the development and progression of ILD, two did not demonstrate an effect and one was inconclusive...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28302218/-investigation-of-lung-cancer-patients-complicated-with-chronic-obstructive-pulmonary-disease-in-thoracic-surgical-department
#4
Rongbao Zhang, Xingyu Tan, Qing Chen, Jingan Wei, Jun Gai, Yan Wang, Ziyi Yang, Jing Li, Liyu Zhu, Zhongxian Huang, Quanying He
BACKGROUND: Lung cancer is an important complication of chronic obstructive pulmonary disease (COPD), and even significantly affects the prognosis of patients with COPD. COPD also affects the postoperative complications and recurrence in patients with lung cancer. This study aims to investigate lung cancer patients complicated with COPD in thoracic surgical department. METHODS: All medical records of lung cancer patients discharged from the Department of Thoracic Surgery of People's Hospital, Peking University during January 2015 and December 2015 were reviewed, including gender, age, tobacco smoke history, harmful occupational exposure, clinic symptom, chest computed tomography (CT) scanning, postoperative pathology result report, discharged diagnosis and spirometry [All patients underwent pulmonary function test are received bronchial dilation test if the based predicted value of forced expiratory volume in one second (FEV1) <70%]...
March 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28302109/interaction-of-cd14-haplotypes-and-soluble-cd14-on-pulmonary-function-in-agricultural-workers
#5
Tricia D LeVan, Lynette M Smith, Art J Heires, Ted R Mikuls, Jane L Meza, Lisa A Weissenburger-Moser, Debra J Romberger
BACKGROUND: Agricultural environments are contaminated with organic dusts containing bacterial components. Chronic inhalation of organic dusts is implicated in respiratory diseases. CD14 is a critical receptor for gram-negative lipopolysaccharide; however, its association with respiratory disease among agricultural workers is unknown. The objective of this study was to determine if serum soluble CD14 (sCD14) levels are associated with lung function among agricultural workers and if this association is modified by genetic variants in CD14...
March 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28299723/mold-and-human-health-a-reality-check
#6
REVIEW
Andrea T Borchers, Christopher Chang, M Eric Gershwin
There are possibly millions of mold species on earth. The vast majority of these mold spores live in harmony with humans, rarely causing disease. The rare species that does cause disease does so by triggering allergies or asthma, or may be involved in hypersensitivity diseases such as allergic bronchopulmonary aspergillosis or allergic fungal sinusitis. Other hypersensitivity diseases include those related to occupational or domiciliary exposures to certain mold species, as in the case of Pigeon Breeder's disease, Farmer's lung, or humidifier fever...
March 16, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28286422/hypersensitivity-pneumonitis-a-complex-lung-disease
#7
REVIEW
Gian Galeazzo Riario Sforza, Androula Marinou
Hypersensitivity pneumonitis (HP), also called extrinsic allergic alveolitis, is a respiratory syndrome involving the lung parenchyma and specifically the alveoli, terminal bronchioli, and alveolar interstitium, due to a delayed allergic reaction. Such reaction is secondary to a repeated and prolonged inhalation of different types of organic dusts or other substances to which the patient is sensitized and hyper responsive, primarily consisting of organic dusts of animal or vegetable origin, more rarely from chemicals...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28277982/mapping-differential-cellular-protein-response-of-mouse-alveolar-epithelial-cells-to-multi-walled-carbon-nanotubes-as-a-function-of-atomic-layer-deposition-coating
#8
Gina M Hilton, Alexia J Taylor, Salik Hussain, Erinn C Dandley, Emily H Griffith, Stavros Garantziotis, Gregory N Parsons, James C Bonner, Michael S Bereman
Carbon nanotubes (CNTs), a prototypical engineered nanomaterial, have been increasingly manufactured for a variety of novel applications over the past two decades. However, since CNTs possess fiber-like shape and cause pulmonary fibrosis in rodents, there is concern that mass production of CNTs will lead to occupational exposure and associated pulmonary diseases. The aim of this study was to use contemporary proteomics to investigate the mechanisms of cellular response in E10 mouse alveolar epithelial cells in vitro after exposure to multi-walled CNTs (MWCNTs) that were functionalized by atomic layer deposition (ALD)...
March 13, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28248570/the-diacetyl-exposed-human-airway-epithelial-secretome-new-insights-into-flavoring-induced-airways-disease
#9
David M Brass, William M Gwinn, Ashlee M Valente, Francine L Kelly, Christie D Brinkley, Andrew E Nagler, M Arthur Moseley, Daniel L Morgan, Scott M Palmer, Matthew W Foster
Bronchiolitis obliterans (BO) is an increasingly important lung disease characterized by fibroproliferative airway lesions and decrements in lung function. Occupational exposure to the artificial food flavoring ingredient diacetyl, commonly used to impart a buttery flavor to microwave popcorn, has been associated with BO development. In the occupational setting, diacetyl vapor is first encountered by the airway epithelium. To better understand the effects of diacetyl vapor on the airway epithelium we used an unbiased proteomic approach to characterize both the apical and basolateral secretomes of air liquid interface cultures of primary human airway epithelial cells from four unique donors after exposure to an occupationally relevant ~1100 ppm of diacetyl vapor or PBS as a control on alternating days...
March 1, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/28241711/-identification-of-occupation-disease-of-one-case-of-lung-cancer-caused-by-the-coke-oven-emissions
#10
H W Ding, L L Yang, L H Gao
No abstract text is available yet for this article.
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28195659/silica-exposure-and-disease-in-semi-precious-stone-craftsmen-minas-gerais-brazil
#11
Ana Paula S Carneiro, Nayara F T Braz, Eduardo Algranti, Olivia M P A Bezerra, Natália P S Araujo, Lênio S Amaral Eng Hyg, Jean L Edmé, Annie Sobaszek, Nathalie Chérot-Kornobis
BACKGROUND: Brazil is an exporter of precious stones and craftsmen often work in poor conditions. We assessed silica-related diseases among crystal craftsmen and the complexity of its control. METHODS: Case-series including 118 subjects evaluated from 2006 to 2015, based on medical interviews, chest X-rays, spirometry, and respirable silica samples. RESULTS: Median age and length of exposure were 32 and 13 years, respectively. Silicosis, with 1/0 as a threshold, was diagnosed radiologically in 57 individuals (48...
March 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/28194087/occupational-bronchiolitis-induced-by-cotton-dust-exposure-in-a-nonsmoker
#12
Richa Mittal, Pawan Gupta, Sunil K Chhabra
The most well-known disease caused by cotton dust is byssinosis though it is also associated with chronic obstructive airways disease, and very rarely, interstitial lung disease. Obliterative bronchiolitis has never been reported in this setting. We report a 63-year-old, nonsmoker male, who presented with complaints of cough and exertional dyspnoea for 10 years. He had worked in textile industry for 35 years and symptoms had persisted even after quitting. Examination revealed prolonged expiration with expiratory wheeze, and pulmonary function tests revealed severe airflow limitation with air trapping and impaired diffusion capacity...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28194086/silicosis-in-the-form-of-progressive-massive-fibrosis-a-diagnostic-challenge
#13
Somnath Bhattacharya, Atin Dey, Amitava Pal, Saurav Kar, Sayantan Saha
Silicosis is a major occupational lung disease with a relatively fatal and irreversible outcome. Early diagnosis for shifting the potential candidates to safe modes of workplace as well as for prevention of further progression is the cornerstone of management. Here, we present a complicated case of silicosis in the form of progressive massive fibrosis, which was initially interpreted as tuberculosis; radiological images had resemblance with tuberculosis and cryptogenic organizing pneumonia. Radiology-guided trucut biopsy was imperative to confirm the diagnosis...
May 2016: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28183200/spirometry-a-predictor-of-lung-cancer-among-asbestos-workers
#14
Beata Świątkowska, Neonila Szeszenia-Dąbrowska
OBJECTIVE: The significance of lung function as an independent risk factor for lung cancer remains unclear. The objective of the study is to answer the question if spirometry can identify patients at risk for lung cancer among people occupationally exposed to asbestos dust in the past. METHODS: In order to identify a group of individuals with the highest risk of lung cancer incidence based on lung function levels of FEV1% predicted value, we examined 6882 subjects enrolled in the health surveillance program for asbestos related diseases over the years 2000-2014...
January 2017: Inhalation Toxicology
https://www.readbyqxmd.com/read/28162043/chest-ultrasonography-in-health-surveillance-of-asbestos-related-lung-diseases
#15
Andrea Smargiassi, Giuliana Pasciuto, Ilaria Pedicelli, Erminia Lo Greco, Mariarosaria Calvello, Riccardo Inchingolo, Gioacchino Schifino, Patrizio Capoluongo, Pasquale Patriciello, Maurizio Manno, Alfonso Cirillo, Giuseppe Maria Corbo, Gino Soldati, Ivo Iavicoli
OBJECTIVES: Exposure to asbestos fibers can lead to different lung diseases, such as pleural thickening and effusion, asbestosis, mesothelioma, and lung cancer. These diseases are expected to peak in the next few years. The aim of the study was to validate ultrasonography (US) as a diagnostic tool in the management of lung diseases in subjects with a history of occupational exposure to asbestos. METHODS: Fifty-nine retired male workers previously exposed to asbestos were enrolled in the study...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28159026/design-and-validation-of-a-self-administered-questionnaire-as-an-aid-to-detection-of-occupational-exposure-to-lung-carcinogens
#16
C Pélissier, V Dutertre, P Fournel, I Gendre, J Michel Vergnon, J Kalecinski, F Tinquaut, L Fontana, F Chauvin
OBJECTIVE: Ten to thirty percent of lung cancer is thought to be of occupational origin. Lung cancer is under-declared as an occupational disease in Europe, and most declarations of occupational disease concern asbestos. The purpose of this study was to design and validate a short, sensitive self-administered questionnaire, as an aid for physicians in detecting occupational exposure to asbestos and other lung carcinogens in order to remedy occupational lung cancer under-declaration. STUDY DESIGN: Cross-sectional study...
February 2017: Public Health
https://www.readbyqxmd.com/read/28153749/energy-landscape-of-a-gstp1-polymorph-linked-with-cytological-function-decay-in-response-to-chemical-stressors
#17
Zarrin Basharat, Azra Yasmin
Gene polymorphisms lead to varied structure and functional properties. A single nucleotide polymorphism (SNP) i.e. Ile105Val (rs1695) in glutathione S-transferase P1 (GSTP1) gene influences cytological toxicity and modulates the risk to occupational diseases. Apart from this, cancer, neuropathy, NOx, SOx and ozone mediated respiratory function decline including lung inflammation, asthma, allergy etc., have been reported in people with this missense mutation. Here, the functional properties of rs1695 polymorph are revisited through a computational approach...
April 20, 2017: Gene
https://www.readbyqxmd.com/read/28149975/two-men-with-dyspnea-enlarged-lymph-nodes-%C3%A2-dx
#18
Ali Abdul-Hai, David Ergas, Miriam Katz, Stephen Dh Malnick
Systolic heart failure has been previously recognized as a cause of reversible mediastinal lymphadenopathy (MLN). Other causes of MLN include sarcoidosis, various malignancies, pulmonary infections, and occupational lung diseases. There are, however, no reports of MLN in patients with diastolic heart failure.
December 2016: Journal of Family Practice
https://www.readbyqxmd.com/read/28141625/social-media-use-for-occupational-lung-disease
#19
Philip Harber, Gondy Leroy
PURPOSE OF REVIEW: Social media have great impact on all aspects of life throughout the world. The utilization of social media for occupational lung disease, however, has been much more limited. This article summarizes recent literature concerning social media for occupational lung disease and identifies areas for additional use. RECENT FINDINGS: Social media are used in six relevant areas: information dissemination, peer-to-peer communication, survey research data collection, participatory research and exposome data acquisition, assessing public concerns, and knowledge generation...
January 30, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28140833/nanoparticles-induced-apoptosis-of-human-airway-epithelium-is-mediated-by-prongf-p75-ntr-signaling
#20
Sreeparna Chakraborty, Vincent Castranova, Miriam K Perez, Giovanni Piedimonte
Environmental and occupational exposures to respirable ultrafine fractions of particulate matter (PM) have been implicated in the initiation and exacerbation of lung diseases. However, the precise mechanisms underlying production of cell damage and death attributed to nanoparticles (NP) on human airway epithelium are not fully understood. This study examined the role of neurotrophic pathways in NP-induced airway toxicity. Size and agglomeration of TiO2 nanoparticles (TiO2-NP) and fine (TiO2-FP) particles were measured by dynamic light scattering...
2017: Journal of Toxicology and Environmental Health. Part A
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