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Occupational lung disease

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https://www.readbyqxmd.com/read/29447338/exposure-lag-response-in-longitudinal-studies-application-of-distributed-lag-non-linear-models-in-an-occupational-cohort
#1
Andreas M Neophytou, Sally Picciotto, Daniel M Brown, Lisa E Gallagher, Harvey Checkoway, Ellen A Eisen, Sadie Costello
Prolonged exposures can have complex relationships with health outcomes, as timing, duration, and intensity of exposure are all potentially relevant. Summary measures such as cumulative exposure or average intensity of exposure may not fully capture these relationships. We applied penalized and unpenalized distributed lag non-linear models (DLNMs) with flexible exposure-response and lag-response functions in order to examine the association between crystalline silica exposure and mortality from lung cancer and non-malignant respiratory disease in a cohort study of 2,342 California diatomaceous earth workers, followed 1942-2011...
February 13, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29432934/alpha-1-antitrypsin-deficiency-from-the-lung-to-the-heart
#2
Ivan Curjuric, Medea Imboden, Robert Bettschart, Seraina Caviezel, Julia Dratva, Marco Pons, Thomas Rothe, Arno Schmidt-Trucksäss, Daiana Stolz, Gian Andri Thun, Arnold von Eckardstein, Florian Kronenberg, Ilaria Ferrarotti, Nicole M Probst-Hensch
BACKGROUND AND AIMS: Alpha-1 antitrypsin (A1AT) is the most abundant serine protease inhibitor in human blood and exerts important anti-inflammatory and immune-modulatory effects. In combination with smoking or other long-term noxious exposures such as occupational dust and fumes, genetic A1AT deficiency can cause chronic obstructive pulmonary disease, a condition with elevated cardiovascular risk. The effects of A1AT deficiency on cardiovascular risk have hardly been studied today. METHODS: Using data from 2614 adults from the population-based SAPALDIA cohort, we tested associations of serum A1AT and SERPINA1 mutations with carotid intima-media thickness (CIMT, measured by B-mode ultrasonography) or self-reported arterial hypertension or cardiovascular disease in multiple regression models using a Mendelian Randomization like analysis design...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29429127/tissue-and-strain-specific-effects-of-a-genotoxic-carcinogen-1-3-butadiene-on-chromatin-and-transcription
#3
Jennifer W Israel, Grace A Chappell, Jeremy M Simon, Sebastian Pott, Alexias Safi, Lauren Lewis, Paul Cotney, Hala S Boulos, Wanda Bodnar, Jason D Lieb, Gregory E Crawford, Terrence S Furey, Ivan Rusyn
Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic control of transcription, and understanding of the chemical effects on both could inform the causal role of epigenetic alterations in disease mechanisms. In this study, we hypothesized that baseline variability in chromatin organization and transcription profiles among various tissues and mouse strains influence the outcome of exposure to the DNA damaging chemical 1,3-butadiene...
February 10, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
https://www.readbyqxmd.com/read/29423230/review-of-carcinogenicity-of-hexavalent-chrome-and-proposal-of-revising-approval-standards-for-an-occupational-cancers-in-korea
#4
Jungwon Kim, Sangyun Seo, Yangho Kim, Dae Hwan Kim
Background: The objective of this study is to suggest revised recognition standards for occupational disease due to chromium (VI) by reflecting recent domestic and international research works and considering domestic exposure status with respect to target organs, exposure period, and cumulative exposure dose in relation to the chromium (VI)-induced occupational disease compensation. Methods: In this study, the reports published by major international institutions such as World Health Organization (WHO) International Agency for Research on Cancer (IARC) (2012), Occupational Safety and Health Administration (OSHA) (2006), National Institute for Occupational Safety and Health (NIOSH) (2013), American Conference of Governmental Industrial Hygienists (ACGIH) (2004), National Toxicology Program (NTP) (2014), and Agency for Toxic Substances and Disease Registry (ASTDR) (2012) were reviewed and the recent research works searched by PubMed were summarized...
2018: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29422043/respiratory-health-effects-of-exposure-to-low-levels-of-airborne-endotoxin-a-systematic-review
#5
REVIEW
Azadèh Farokhi, Dick Heederik, Lidwien A M Smit
BACKGROUND: Elevated endotoxin levels have been measured in ambient air around livestock farms, which is a cause of concern for neighbouring residents. There is clear evidence that occupational exposure to high concentrations of airborne endotoxin causes respiratory inflammation, respiratory symptoms and lung function decline. However, health effects of exposure to low levels of endotoxin are less well described. The aim of this systematic review is to summarize published associations between exposure to relatively low levels of airborne endotoxin and respiratory health endpoints...
February 8, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29417838/lung-cancer-a-brief-review-of-epidemiology-and-screening
#6
Cláudia Gouvinhas, Ramon Andrade De Mello, Daniela Oliveira, José Manuel Castro-Lopes, Pedro Castelo-Branco, Ricardo Sales Dos Santos, Venceslau Hespanhol, Daniel Humberto Pozza
The global burden of lung cancer has been increasing over the past years, and is still a major threat to public health worldwide, leading to disabilities and premature mortality. Despite multifactorial cause, smoking remains as the major etiological factor, followed by occupational exposure to carcinogens, genetic predisposition and other concomitant diseases. In order to reduce the individual and social burden due to the direct and indirect costs related to the lung cancer treatment, accurate methods of screening are needed...
February 8, 2018: Future Oncology
https://www.readbyqxmd.com/read/29413507/respiratory-effects-of-trichloroethylene
#7
REVIEW
Orianne Dumas, Thomas Despreaux, Frédéric Perros, Edmund Lau, Pascal Andujar, Marc Humbert, David Montani, Alexis Descatha
Trichloroethylene (TCE) is a chlorinated solvent that has been used widely around the world in the twentieth century for metal degreasing and dry cleaning. Although TCE displays general toxicity and is classified as a human carcinogen, the association between TCE exposure and respiratory disorders are conflicting. In this review we aimed to systematically evaluate the current evidence for the respiratory effects of TCE exposure and the implications for the practicing clinician. There is limited evidence of an increased risk of lung cancer associated with TCE exposure based on animal and human data...
January 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29394417/association-analysis-identifies-new-risk-loci-for-coal-workers-pneumoconiosis-in-han-chinese-men
#8
Ting Wang, Yan Li, Meng Zhu, Wenxi Yao, Hongyan Wu, Xiaoming Ji, Zhibin Hu, Hongbing Shen, Xiangshan Fan, Chunhui Ni
Coal worker's pneumoconiosis (CWP) is a debilitating and progressive occupational lung disease resulted from long-term inhalation of airborne silica-containing coal mine dust. Both environmental factors and genetic variations contribute to CWP. Our previous genome-wide association study (GWAS) revealed a tiny fraction of variants with the top associations in Chinese Han population. To identify novel susceptibility loci of CWP, functional variants with suboptimal associations in the GWAS scan were further studied here...
January 31, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29394172/the-emerging-spectrum-of-exposure-related-bronchiolitis
#9
Silpa D Krefft, Carlyne D Cool, Cecile S Rose
PURPOSE OF REVIEW: Exposure-related bronchiolitis is increasingly recognized as an important but challenging clinical diagnosis. Acute and chronic inhalational exposures are associated with variable clinical presentations and a spectrum of histopathologic abnormalities affecting the small airways. This review provides an overview of the histologic patterns and occupational settings for exposure-related bronchiolitis, along with recent advances in disease diagnosis and management. RECENT FINDINGS: The entire histopathologic spectrum of bronchiolitis (constrictive, obliterative, proliferative, lymphocytic, respiratory) has been reported in exposure-related bronchiolitis...
February 1, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29388718/neonatal-respiratory-distress-syndrome-and-underlying-mechanisms-in-cloned-cattle
#10
Yifan Rao, Xiuzhu Sun, Na Yang, Fanyi Zhang, Xiaojing Jiang, Linhua Huang, Xiaogai Guo, Weihua Du, Haisheng Hao, Xueming Zhao, Qiuling Jiang, Yan Liu
Neonatal respiratory distress is a major mortality factor in cloned animals, but the pathogenesis of this disease is rarely investigated. In this study, four neonatal cloned cattle, born after full-term gestation, exhibited symptoms of neonatal respiratory distress syndrome (NRDS), which included symptoms of hyaline membrane disease as well as disordered surfactant homeostasis in their collapsed lungs. No differences in DNA methylation or histone modifications correlated with the suppressed SPB and SPC transcription observed in the cloned cattle group (P > 0...
February 1, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29378587/prevalence-and-characteristics-of-copd-among-pneumoconiosis-patients-at-an-occupational-disease-prevention-institute-a-cross-sectional-study
#11
Yating Peng, Xin Li, Shan Cai, Yan Chen, Weirong Dai, Wenfeng Liu, Zijing Zhou, Jiaxi Duan, Ping Chen
BACKGROUND: Pneumoconiosis may play an important role in the development of chronic obstructive pulmonary disease (COPD), and the complication of COPD may impose a heavy burden of illness. METHODS: The study was conducted in Hunan Province in China from December 1, 2015, to December 1, 2016. Consecutive underground male pneumoconiosis patients employed for at least 1 year were recruited from the Hunan Occupational Disease Prevention Institute. Patient information, respiratory symptoms and clinical data were collected using a structured questionnaire...
January 29, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29373770/-spirometry-in-a-population-of-coal-miners-in-paipa-colombia
#12
Nubia González, Sara Lucía Díaz, Myriam Rocío Wilches, Mabel Patricia Franky, Cesar Méndez A, Andrea Del Rosario Herrera
INTRODUCTION: Respiratory diseases resulting from exposure to particulate matter such as in coal mining remains a research challenge in this country and a public health issue. Spirometry is a basic test of fundamental respiratory function for the diagnosis and monitoring of these types of chronic lung diseases. OBJECTIVE: To determine spirometric values in the coal mining municipality of Paipa and their association with age and occupational exposure times. MATERIALS AND METHODS: We conducted a descriptive cross-sectional study...
December 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29370680/health-effects-of-environmental-pollution-in-population-living-near-industrial-complex-areas-in-korea
#13
Sang-Yong Eom, Sanghyuk Bae, Ji-Ae Lim, Guen-Bae Kim, Seung-Do Yu, Yangho Kim, Hyun-Sul Lim, Bu-Soon Son, Domyung Paek, Yong-Dae Kim, Heon Kim, Mina Ha, Ho-Jang Kwon
Several epidemiological studies have reported an association between environmental pollution and various health conditions in individuals residing in industrial complexes. To evaluate the effects of pollution from industrial complex on human health, we performed a pooled analysis of environmental epidemiologic monitoring data for residents living near national industrial complexes in Korea. The respiratory and allergic symptoms and the prevalence of acute and chronic diseases, including cancer, were used as the outcome variables for health effects...
January 16, 2018: Environmental Health and Toxicology
https://www.readbyqxmd.com/read/29342164/environmental-dust-inhalation-in-the-european-badger-meles-meles-systemic-distribution-of-silica-laden-macrophages-pathological-changes-and-association-with-mycobacterium-bovis-infection-status
#14
Janne M Schoening, Leigh A L Corner, Locksley L McV Messam, Joseph P Cassidy, Alan Wolfe
Chronic inhalation of crystalline silica and silicates may lead to severe lung disease in humans, termed silicosis. The disease is an occupational health concern in miners and related professions worldwide. Silicosis is also a strong risk factor for tuberculosis in humans. Due to its subterranean lifestyle, the European badger (Meles meles) is continuously exposed to environmental dust, while this species is also susceptible to tuberculosis, caused by Mycobacterium bovis. To date, a thorough investigation of mineral dust retention and its possible implication as a risk factor for mycobacterial infection in badgers has not been performed...
2018: PloS One
https://www.readbyqxmd.com/read/29337701/update-on-metal-induced-occupational-lung-disease
#15
Anne E Wyman, Stella E Hines
PURPOSE OF REVIEW: Occupational and environmental exposures to metals can result in multiple pulmonary conditions. This article will review recent epidemiologic and mechanistic studies that have enhanced our understanding of the association between particular lung diseases and exposure to specific metals. RECENT FINDINGS: Recent studies have broadened our understanding of the mechanisms of lung diseases such as CBD in established industries and drawn attention to conditions that may arise from exposure to metals such as indium in developing technologies...
January 13, 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29324056/cardiopulmonary-effects-induced-by-occupational-exposure-to-titanium-dioxide-nanoparticles
#16
Lin Zhao, Yifang Zhu, Zhangjian Chen, Huadong Xu, Jingwen Zhou, Shichuan Tang, Zhizhen Xu, Fanling Kong, Xinwei Li, Yifei Zhang, Xianzuo Li, Ji Zhang, Guang Jia
Although some toxicological studies have reported that exposure to titanium dioxide nanoparticles (nano-TiO2) may elicit adverse cardiopulmonary effects, related data collected from human are currently limited. The purpose of this study is to explore cardiopulmonary effects among workers who were exposed to nano-TiO2 and to identify biomarkers associated with exposure. A cross-sectional study was conducted in a nano-TiO2 manufacturing plant in eastern China. Exposure assessment and characterization of TiO2 particles were performed in a packaging workshop...
January 11, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29319052/measurement-of-lung-cancer-tumor-markers-in-a-glass-wool-company-workers-exposed-to-respirable-synthetic-vitreous-fiber-and-dust
#17
Shabnam Abtahi, Mahyar Malekzadeh, Ghafour Nikravan, Abbas Ghaderi
BACKGROUND: Occupational exposures to respirable synthetic vitreous fiber (SVF) and dust are associated with many lung diseases including lung cancer. Low-dose computed tomography is used for screening patients who are highly suspicious of having lung carcinoma. However, it seems not to be cost-effective. Serum biomarkers could be a useful tool for the surveillance of occupational exposure, by providing the possibility of diagnosing lung cancer in its early stages. OBJECTIVE: To determine if serum carcinoembryonic antigen (CEA) and cytokeratin fragment (CYFRA) 21-1 levels in workers exposed more than normal population to respirable SVF and dust may be used as indicators of progression towards lung cancer...
January 2018: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29316765/-analysis-of-clinical-features-in-patients-with-pneumoconiosis-complicated-with-pulmonary-emphysema
#18
X Li, W R Dai, L Li, W F Liu, Z X Yang, L Xie
Objective: To investigate the clinical features of pneumoconiosis complicated with pulmo-nary emphysema. Methods: selected 868 patients with pneumoconiosis were selected from December 2015 to December 2016 in Hunan occupational disease prevention and treatment hospital. Collected the results of high-resolution spiral CT, arterial blood gas, ECG, pulmonary function and MRC score. The subjects were divided into pneumoconiosis complicated with pulmonary emphysema group and simple pneumoconiosis group accord-ing to the results of HRCT...
November 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/29284684/chest-physician-reported-work-related-long-latency-respiratory-disease-in-great%C3%A2-britain
#19
Melanie Carder, Andrew Darnton, Matthew Gittins, S Jill Stocks, David Ross, Chris M Barber, Raymond M Agius
Much of the current burden of long-latency respiratory disease (LLRD) in Great Britain is attributed to historical asbestos exposure. However, continuing exposure to other agents, notably silica, also contributes to disease burden. The aim of this study was to investigate the incidence of work-related LLRD reported by chest physicians in Great Britain, including variations by age, gender, occupation and suspected agent.LLRD incidence and incidence rate ratios by occupation were estimated (1996-2014). Mesothelioma cases by occupation were compared with proportional mortality ratios...
December 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29277064/reduced-serum-club-cell-protein-as-a-pulmonary-damage-marker-for-chronic-fine-particulate-matter-exposure-in-chinese-population
#20
Yanhua Wang, Huawei Duan, Tao Meng, Meili Shen, Qianpeng Ji, Jie Xing, Qingrong Wang, Ting Wang, Yong Niu, Tao Yu, Zhong Liu, Hongbing Jia, Yuliang Zhan, Wen Chen, Zhihu Zhang, Wenge Su, Yufei Dai, Xuchun Zhang, Yuxin Zheng
BACKGROUND: Exposure to fine particulate matter (PM2.5) pollution is associated with increased morbidity and mortality from respiratory diseases. However, few population-based studies have been conducted to assess the alterations in circulating pulmonary proteins due to long-term PM2.5 exposure. METHODS: We designed a two-stage study. In the first stage (training set), we assessed the associations between PM2.5 exposure and levels of pulmonary damage markers (CC16, SP-A and SP-D) and lung function in a coke oven emission (COE) cohort with 558 coke plant workers and 210 controls...
December 21, 2017: Environment International
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