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Occupational lung disease

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https://www.readbyqxmd.com/read/29622826/hot-tub-lung-an-intriguing-diffuse-parenchymal-lung-disease
#1
Mohan Rudrappa, Laxmi Kokatnur
In pulmonary medicine, identical pathogenesis due to varied etiological agents can present with indistinguishable clinical presentation, and produce similar laboratory and radiological changes. The importance of eliciting detailed occupational and social history from patients cannot be stressed enough when dealing with patients suffering from diffuse parenchymal lung diseases. Hot Tub Lung(HTL) is a perplexing pulmonary disease attributed to the Mycobacterium Avium-intracellulare Complex (MAC). MAC is a ubiquitous atypical mycobacterium present in moist environment, and is not considered pathogenic, without the predisposing conditions like immunosuppression...
September 2017: Ghana Medical Journal
https://www.readbyqxmd.com/read/29617927/estimating-counterfactual-risk-under-hypothetical-interventions-in-the-presence-of-competing-events-crystalline-silica-exposure-and-mortality-from-two-causes-of-death
#2
Andreas M Neophytou, Sally Picciotto, Daniel M Brown, Lisa E Gallagher, Harvey Checkoway, Ellen A Eisen, Sadie Costello
Exposure to silica has been linked to excess risk of lung cancer and non-malignant respiratory disease mortality. In this study we estimated risk for both these outcomes in relation to occupational silica exposure as well as the reduction in risk that would result from hypothetical interventions on exposure in a cohort of exposed workers. Analyses were carried out in an all-male study population consisting of 2342 California diatomaceous earth workers regularly exposed to crystalline silica, followed between 1942 and 2011...
April 3, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29615629/asbestosis-is-prevalent-in-a-variety-of-construction-industry-trades
#3
G I Walters, A S Robertson, P S Bhomra, P S Burge
A diagnosis of asbestosis, which is a long-latency, fibrotic lung disease, has implications for the patient in terms of prognosis, treatment and compensation. Identifying and quantifying asbestos exposure is difficult without a detailed occupational history, and the threshold dose of asbestos required to cause asbestosis is not well understood. We reviewed all cases of asbestosis diagnosed between 2001 and 2016 at the Birmingham Regional NHS Occupational Lung Disease Service to determine the industries and occupations most frequently implicated in causation, in order to help clinicians identify where asbestosis might enter the differential diagnosis for a patient with chronic respiratory symptoms...
April 3, 2018: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29611614/occupational-lung-cancer-among-fisherman-a-triple-case-report
#4
Tarik Ghailan, Mustapha El Ftouh
BACKGROUND: The World Health Organisation places lung cancer as the leading cause of cancer mortality in the world. The fishermen are one of the most important consumers of tobacco, which remains the main risk factor for lung cancer. However, there are no epidemiological data on the role of other causes, particularly occupational ones, in genesis of this disease. The objective of our work is to expose medical and occupational data of 3 fishermen with lung cancer and discuss a possible occupational origin of their pathology...
2018: International Maritime Health
https://www.readbyqxmd.com/read/29592863/cadmium-in-tobacco-smokers-a-neglected-link-to-lung-disease
#5
REVIEW
Koustav Ganguly, Bettina Levänen, Lena Palmberg, Agneta Åkesson, Anders Lindén
Cadmium in tobacco smoke may contribute to the development of pulmonary emphysema. However, there is poor understanding of the mechanisms behind the pathogenic role of cadmium in this and other smoking-related lung diseases. The traditional focus on the total body burden of cadmium, estimated through analysis of urine, may not fully reflect the local burden of cadmium, since it is inhaled by smokers. Thus, assessing the local accumulation of cadmium in the lungs appears more relevant, given that there is tissue-specific retention of cadmium...
March 31, 2018: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29590255/use-of-cardiopulmonary-exercise-testing-to-assess-early-ventilatory-changes-related-to-occupational-particulate-matter
#6
T P Chao, E F Sperandio, T L V P Ostolin, V R Almeida, M Romiti, A R T Gagliardi, R L Arantes, V Z Dourado
Spirometry has been used as the main strategy for assessing ventilatory changes related to occupational exposure to particulate matter (OEPM). However, in some cases, as one of its limitations, it may not be sensitive enough to show abnormalities before extensive damage, as seen in restrictive lung diseases. Therefore, we hypothesized that cardiopulmonary exercise testing (CPET) may be better than spirometry to detect early ventilatory impairment caused by OEPM. We selected 135 male workers with at least one year of exposure...
March 26, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29584453/rural-residence-and-copd-exacerbations-analysis-of-the-spiromics-cohort
#7
Robert M Burkes, Amanda J Gassett, Agathe S Ceppe, Wayne Anderson, Wanda K O'Neal, Prescott G Woodruff, Jerry A Krishnan, R Graham Barr, MeiLan K Han, Fernando J Martinez, Alejandro P Comellas, Allison A Lambert, Joel D Kaufman, Mark T Dransfield, J Michael Wells, Richard E Kanner, Robert Paine, Eugene R Bleecker, Laura M Paulin, Nadia N Hansel, M Bradley Drummond
RATIONALE: Rural residence is associated with poor outcomes in several chronic diseases. The association between rural residence and chronic obstructive pulmonary disease (COPD) exacerbations remains unclear. OBJECTIVE: To determine the independent association between rural residence and COPD-related outcomes including COPD exacerbations, airflow obstruction and symptom burden. METHODS: A total of 1684 Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) participants with FEV1/FVC<0...
March 27, 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29574493/immigrant-respiratory-health-a-diverse-perspective-in-environmental-influences-on-respiratory-health
#8
REVIEW
Andrea A Pappalardo, Giselle Mosnaim
PURPOSE OF REVIEW: The aim of this review is to examine the prevalence of and impact of environmental exposures in the workplace and home on immigrant respiratory health in the USA. RECENT FINDINGS: Few studies report levels of workplace and home environmental exposures for immigrant children and adults, and documenting these findings is an important first step to addressing their respiratory health concerns. Rates of respiratory disease are lowest upon first arrival and increase with duration of residency in the USA...
March 24, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29569274/the-effects-of-acetaldehyde-exposure-on-histone-modifications-and-chromatin-structure-in-human-lung-bronchial-epithelial-cells
#9
Danqi Chen, Lei Fang, Hongjie Li, Chunyuan Jin
As the primary metabolite of alcohol and the most abundant carcinogen in tobacco smoke, acetaldehyde is linked to a number of human diseases associated with chronic alcohol consumption and smoking including cancers. In addition to direct DNA damage as a result of the formation of acetaldehyde-DNA adducts, acetaldehyde may also indirectly impact proper genome function through the formation of protein adducts. Histone proteins are the major component of the chromatin. Post-translational histone modifications (PTMs) are critically important for the maintenance of genetic and epigenetic stability...
March 22, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29543564/chest-ct-scan-findings-in-world-trade-center-workers
#10
Rafael E de la Hoz, Jonathan Weber, Dongming Xu, John T Doucette, Xiaoyu Liu, Deborah A Carson, Juan C Celedón
We examined the chest CT scans of 1,453 WTC responders using the International Classification of High-resolution CT for Occupational and Environmental Respiratory Diseases. Univariate and bivariate analyses of potential work-related pleural abnormalities were performed with pre-WTC and WTC-related occupational exposure data, spirometry, demographics and quantitative CT measurements. Logistic regression was used to evaluate occupational predictors of those abnormalities. Chest CT scans were performed first at a median of 6...
March 15, 2018: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/29538276/a-review-and-meta-analysis-of-occupational-titanium-dioxide-exposure-and-lung-cancer-mortality
#11
Hien Q Le, John A Tomenson, David B Warheit, Jon P Fryzek, Ashley P Golden, Elizabeth D Ellis
OBJECTIVE: A review of studies of occupational titanium dioxide (TiO2) exposure was conducted, and results from the three industry-based cohort mortality studies were summarized using meta-analysis. METHODS: Summary standardized mortality ratios (SSMR) and summary Cox regression coefficients from exposure-response models were derived using random effects models. RESULTS: Results from studies of 24,312 TiO2 production workers were combined...
March 13, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29528143/nickel-exposure-induces-persistent-mesenchymal-phenotype-in-human-lung-epithelial-cells-through-epigenetic-activation-of-zeb1
#12
Cynthia C Jose, Lakshmanan Jagannathan, Vinay Singh Tanwar, Xiaoru Zhang, Chongzhi Zang, Suresh Cuddapah
Nickel (Ni) is an environmental and occupational carcinogen, and exposure to Ni is associated with lung and nasal cancers in humans. Furthermore, Ni exposure is implicated in several lung diseases including chronic inflammatory airway diseases, asthma and fibrosis. However, the mutagenic potential of Ni is low and does not correlate with its potent toxicity and carcinogenicity. Therefore, mechanisms underlying Ni exposure-associated diseases remain poorly understood. Since the health risks of environmental exposures often continue post exposure, understanding the exposure effects that persist after the termination of exposure could provide mechanistic insights into diseases...
March 12, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29518070/dental-personnel-treated-for-idiopathic-pulmonary-fibrosis-at-a-tertiary-care-center-virginia-2000-2015
#13
Randall J Nett, Kristin J Cummings, Brenna Cannon, Jean Cox-Ganser, Steven D Nathan
In April 2016, a Virginia dentist who had recently received a diagnosis of idiopathic pulmonary fibrosis (IPF) and was undergoing treatment at a specialty clinic at a Virginia tertiary care center contacted CDC to report concerns that IPF had been diagnosed in multiple Virginia dentists who had sought treatment at the same specialty clinic. IPF is a chronic, progressive lung disease of unknown cause and associated with a poor prognosis (1). Although IPF has been associated with certain occupations (2), no published data exist regarding IPF in dentists...
March 9, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29515016/answer-to-photo-quiz-occupational-lung-disease-on-a-farm
#14
(no author information available yet)
No abstract text is available yet for this article.
March 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29515015/occupational-lung-disease-on-a-farm
#15
H Li, B Wang, J H Keshavamurthy, N B Thomson
No abstract text is available yet for this article.
March 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29484482/new-interplay-between-interstitial-and-alveolar-macrophages-explains-pulmonary-alveolar-proteinosis-pap-induced-by-indium-tin-oxide-particles
#16
François Huaux, Valentin De Gussem, Astrid Lebrun, Yousof Yakoub, Mihaly Palmai-Pallag, Saloua Ibouraadaten, Francine Uwambayinema, Dominique Lison
Occupational exposure to indium tin oxide (ITO) particles has been associated with the development of severe lung diseases, including pulmonary alveolar proteinosis (PAP). The mechanisms of this lung toxicity remain unknown. Here, we reveal the respective roles of resident alveolar (Siglec-Fhigh AM) and recruited interstitial (Siglec-Flow IM) macrophages contributing in concert to the development of PAP. In mice treated with ITO particles, PAP is specifically associated with IL-1α (not GM-CSF) deficiency and Siglec-Fhigh AM (not Siglec-Flow IM) depletion...
April 2018: Archives of Toxicology
https://www.readbyqxmd.com/read/29481529/dosimetry-is-key-to-good-epidemiology-workers-at-mallinckrodt-chemical-works-had-seven-different-source-exposures
#17
Elizabeth D Ellis, John D Boice, Ashley P Golden, David J Girardi, Sarah S Cohen, Michael T Mumma, Roy E Shore, Richard W Leggett, George D Kerr
Mallinckrodt Chemical Works was the earliest uranium processing facility in the Manhattan Project, beginning in 1942. Even then, concern existed about possible health effects resulting from exposure to radiation and pitchblende dust. This concern was well founded as the facility processed Belgian Congo pitchblende ore that was up to 60% pure uranium with high U content and up to 100 mg of radium per ton. Workers were exposed to external gamma radiation plus internal radiation from inhalation and ingestion of pitchblende dust (uranium, radium, and silica)...
April 2018: Health Physics
https://www.readbyqxmd.com/read/29466814/-dgp-interstitial-lung-disease-patient-questionnaire
#18
M Kreuter, U Ochmann, D Koschel, J Behr, F Bonella, M Claussen, U Costabel, S Jungmann, M Kolb, D Nowak, F Petermann, M Pfeiffer, M Polke, A Prasse, J Schreiber, J Wälscher, H Wirtz, D Kirsten
BACKGROUND:  Interstitial lung diseases (ILD) encompass different heterogeneous, mainly chronic diseases of the pulmonary interstitium and/or alveoli with known and unknown reasons. The diagnostic of ILD is challenging and should be performed interdisciplinary. The medical history is of major importance and therefore, in German-speaking countries the Frankfurter Bogen (published in 1985) was utilised to scrutinise the medical history of the patient. This by now more than 30-years-old questionnaire requires a revision with regard to content and language...
February 21, 2018: Pneumologie
https://www.readbyqxmd.com/read/29465110/james-craufurd-gregory-19th-century-scottish-physicians-and-the-link-between-occupation-as-a-coal-miner-and-lung-disease
#19
K Donaldson, W A Wallace, T A Elliot, C Henry
By the mid-19th century about 200,000 miners were employed in a UK coal mining industry still growing with the advances of the Industrial Revolution. Coal miners were long known to suffer poor health but the link to inhaling dust in the mines had not been made. In 1813 George Pearson was the first to suggest that darkening of lungs seen in normal individuals as they aged was caused by inhaled soot from burning oil, candles and coal, which were the common domestic sources of heat and light. In 1831 Dr James Craufurd Gregory first described black pigmentation and disease in the lungs of a deceased coal miner and linked this to pulmonary accumulation of coal mine dust...
September 2017: Journal of the Royal College of Physicians of Edinburgh
https://www.readbyqxmd.com/read/29459517/reduced-lung-function-and-cerebral-small-vessel-disease-in-japanese-men-the-shiga-epidemiological-study-of-subclinical-atherosclerosis-sessa
#20
Ruriko Seto-Yukimura, Emiko Ogawa, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Kazuhiko Nozaki, Akira Fujiyoshi, Katsuyuki Miura, Yasutaka Nakano, Hirotsugu Ueshima
AIM: We aimed to investigate the association between reduced lung function and cerebral small vessel diseases via cranial magnetic resonance imaging (MRI) in the cross-sectional study of the general Japanese population. METHODS: We recruited participants aged ≥40 years from the general population of a single city in Japan. We clarified the comorbidities and treatments, smoking habits, second-hand smoke exposure, current alcohol consumption, education level, exercise habits, and occupation...
February 16, 2018: Journal of Atherosclerosis and Thrombosis
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