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Occupational lung disease

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https://www.readbyqxmd.com/read/29217870/temporal-prediction-of-future-state-occupation-in-a-multistate-model-from-high-dimensional-baseline-covariates-via-pseudo-value-regression
#1
Sandipan Dutta, Susmita Datta, Somnath Datta
In many complex diseases such as cancer, a patient undergoes various disease stages before reaching a terminal state (say disease free or death). This fits a multistate model framework where a prognosis may be equivalent to predicting the state occupation at a future time t. With the advent of high throughput genomic and proteomic assays, a clinician may intent to use such high dimensional covariates in making better prediction of state occupation. In this article, we offer a practical solution to this problem by combining a useful technique, called pseudo value regression, with a latent factor or a penalized regression method such as the partial least squares (PLS) or the least absolute shrinkage and selection operator (LASSO), or their variants...
2017: Journal of Statistical Computation and Simulation
https://www.readbyqxmd.com/read/29216763/upregulated-mir-29c-suppresses-silica-induced-lung-fibrosis-through-the-wnt-%C3%AE-catenin-pathway-in-mice
#2
X Wang, K Xu, X Y Yang, J Liu, Q Zeng, F S Wang
Silicosis is an irreversible lung disease resulting from long-term inhalation of occupational dust containing silicon dioxide. However, the pathogenesis of silicosis has not been clearly understood yet. Accumulating evidence suggests that miR-29 may have a significant anti-fibrotic capacity, meanwhile it may relate to Wnt/β-catenin pathway. The purpose of this study was to discuss the role of miR-29 in the progression of silicosis. A lentiviral vector was constructed, named Lv-miR-29c, which was overexpressing miR-29c...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29216202/composition-and-variation-of-respiratory-microbiota-in-healthy-military-personnel
#3
Jun Hang, Nela Zavaljevski, Yu Yang, Valmik Desai, Richard C Ruck, Louis R Macareo, Richard G Jarman, Jaques Reifman, Robert A Kuschner, Paul B Keiser
Certain occupational and geographical exposures have been associated with an increased risk of lung disease. As a baseline for future studies, we sought to characterize the upper respiratory microbiomes of healthy military personnel in a garrison environment. Nasal, oropharyngeal, and nasopharyngeal swabs were collected from 50 healthy active duty volunteers eight times over the course of one year (1107 swabs, completion rate = 92.25%) and subjected to pyrosequencing of the V1-V3 region of 16S rDNA. Respiratory bacterial taxa were characterized at the genus level, using QIIME 1...
2017: PloS One
https://www.readbyqxmd.com/read/29186624/local-and-systemic-inflammation-may-mediate-diesel-engine-exhaust-induced-lung-function-impairment-in-a-chinese-occupational-cohort
#4
Haitao Wang, Huawei Duan, Tao Meng, Mo Yang, Lianhua Cui, Ping Bin, Yufei Dai, Yong Niu, Meili Shen, Liping Zhang, Yuxin Zheng, Shuguang Leng
Diesel exhaust (DE) as the major source of vehicle-emitted particle matter in ambient air impairs lung function. The objectives were to assess the contribution of local (e.g., the fraction of exhaled nitric oxide [FeNO] and serum Club cell secretory protein [CC16]) and systemic (e.g., serum C-reaction protein [CRP] and interleukin-6 [IL-6]) inflammation to DE induced lung function impairment using a unique cohort of diesel engine testers (DET, n = 137) and non-DETs (n = 127), made up of current and non-current smokers...
November 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29179515/characteristics-survival-and-risk-factors-of-chinese-young-lung-cancer-patients-the-experience-from-two-institutions
#5
Jianjie Li, Fan Yang, Xiao Li, Min Zhang, Ruozi Fu, Xiaodan Yin, Jun Wang
Limited data is available regarding lung cancer in Chinese young adults. This study was aimed to determine the characteristics, survival, and prognostic factors of young lung cancer patients in China. We reviewed demographic and clinical data, and survival information of 420 young patients (20-45 years old) diagnosed with lung cancer in two Chinese hospitals between 2000 and 2013. The results showed that lung cancer occurred more frequently (70%) and affected more males than females (43.8% vs 26.7%) in patients older than 36; whereas, more females were affected under age 35 (16...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29167298/prevalence-and-burden-of-chronic-bronchitis-symptoms-results-from-the-bold-study
#6
Filip Mejza, Louisa Gnatiuc, A Sonia Buist, William M Vollmer, Bernd Lamprecht, Daniel O Obaseki, Pawel Nastalek, Ewa Nizankowska-Mogilnicka, Peter G J Burney
We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study.Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years.Data from 24 855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bronchitis across sites, from 10...
November 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29165103/occupation-exposed-to-road-traffic-emissions-and-respiratory-health-among-congolese-transit-workers-particularly-bus-conductors-in-kinshasa-a-cross-sectional-study
#7
Etongola Papy Mbelambela, Ryoji Hirota, Masamitsu Eitoku, Sifa Marie Joelle Muchanga, Hidenori Kiyosawa, Kahoko Yasumitsu-Lovell, Ontshick Leader Lawanga, Narufumi Suganuma
OBJECTIVES: Road-traffic emissions (RTE) induce adverse health effects, notably respiratory symptoms and respiratory diseases, as a result of pollutants deposited into the respiratory tract. The aim of this study was to evaluate the association between occupation groups of Congolese transit workers exposed to RTE, particularly bus conductors and respiratory health, in Kinshasa. METHODS: A cross-sectional study was conducted from 2015 April 20(th) to May 14(th), whose participants were bus conductors (n = 110), bus drivers (n = 107), taxi-motorcyclists (n = 102) and high school teachers (control group; n = 106)...
March 20, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29160385/usual-interstitial-pneumonia-typical-possible-and-inconsistent-patterns
#8
Pedro Paulo Teixeira E Silva Torres, Marcelo Fouad Rabahi, Maria Auxiliadora Carmo Moreira, Gustavo de Souza Portes Meirelles, Edson Marchiori
Idiopathic pulmonary fibrosis is a severe and progressive chronic fibrosing interstitial lung disease, a definitive diagnosis being established by specific combinations of clinical, radiological, and pathological findings. According to current international guidelines, HRCT plays a key role in establishing a diagnosis of usual interstitial pneumonia (UIP). Current guidelines describe three UIP patterns based on HRCT findings: a typical UIP pattern; a pattern designated "possible UIP"; and a pattern designated "inconsistent with UIP", each pattern having important diagnostic implications...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29157144/personal-exposure-of-dairy-workers-to-dust-endotoxin-muramic-acid-ergosterol-and-ammonia-on-large-scale-dairies-in-the-high-plains-western-united-states
#9
Margaret E Davidson, Joshua Schaeffer, Maggie L Clark, Sheryl Magzamen, Elizabeth J Brooks, Thomas J Keefe, Mary Bradford, Noa Roman-Muniz, John Mehaffy, Gregory Dooley, Jill A Poole, Frank M Mitloehner, Sue Reed, Marc B Schenker, Stephen J Reynolds
Dairy workers experience a high degree of bioaerosol exposure, composed of an array of biological and chemical constituents, which have been tied to adverse health effects. A better understanding of the variation in the magnitude and composition of exposures by task is needed to inform worker protection strategies. To characterize the levels and types of exposures, 115 dairy workers grouped into three task categories on nine farms in the high plains western United States underwent personal monitoring for inhalable dust, endotoxin, 3-hydroxy fatty acids (3-OHFA), muramic acid, ergosterol, and ammonia over one work shift...
November 20, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29141963/current-and-new-challenges-in-occupational-lung-diseases
#10
REVIEW
Sara De Matteis, Dick Heederik, Alex Burdorf, Claudio Colosio, Paul Cullinan, Paul K Henneberger, Ann Olsson, Anne Raynal, Jos Rooijackers, Tiina Santonen, Joaquin Sastre, Vivi Schlünssen, Martie van Tongeren, Torben Sigsgaard
Occupational lung diseases are an important public health issue and are avoidable through preventive interventions in the workplace. Up-to-date knowledge about changes in exposure to occupational hazards as a result of technological and industrial developments is essential to the design and implementation of efficient and effective workplace preventive measures. New occupational agents with unknown respiratory health effects are constantly introduced to the market and require periodic health surveillance among exposed workers to detect early signs of adverse respiratory effects...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29135200/overview-of-silica-related-clusters-in-the-united-states-will-fracking-operations-become-the-next-cluster
#11
M Thomas Quail
Silicosis is the oldest know occupational pulmonary disease. It is a progressive disease and any level of exposure to respirable crystalline silica particles or dust has the potential to develop into silicosis. Silicosis is caused by silica particles or dust entering the lungs and damaging healthy lung tissue. The damage restricts the ability to breathe. Exposure to silica increases a worker’s risk of developing cancer or tuberculosis. This special report will provide background history of silicosis in the U...
January 2017: Journal of Environmental Health
https://www.readbyqxmd.com/read/29129170/comprehensive-guide-to-the-diagnosis-and-management-of-occupational-lung-diseases
#12
Arthur Bill W Musk
No abstract text is available yet for this article.
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29129163/occupational-lung-diseases-in-australia
#13
REVIEW
Ryan F Hoy, Fraser Brims
Occupational exposures are an important determinant of respiratory health. International estimates note that about 15% of adult-onset asthma, 15% of chronic obstructive pulmonary disease and 10-30% of lung cancer may be attributable to hazardous occupational exposures. One-quarter of working asthmatics either have had their asthma caused by work or adversely affected by workplace conditions. Recently, cases of historical occupational lung diseases have been noted to occur with new exposures, such as cases of silicosis in workers fabricating kitchen benchtops from artificial stone products...
November 20, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/29118577/associations-between-occupational-inhalation-risks-and-feno-levels-in-airway-obstruction-patients-results-from-the-national-health-and-nutrition-examination-survey-2007-2012
#14
Yi-Chih Huang, Mei-Chen Yang
Purpose: To investigate associations between occupational inhalation risks and fractional exhaled nitric oxide (FeNO) levels in patients with chronic obstructive pulmonary disease (COPD). Patients and methods: Data of 16,486 subjects who had undergone spirometry with pre-bronchodilator and post-bronchodilator lung function assessment were retrieved from the National Health and Nutrition Examination Survey, 2007-2012 database. After excluding 2,638 subjects with missing spirometry values, data of 13,336 subjects were included for analysis...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29104652/plain-and-contrast-enhanced-chest-computed-tomography-scan-findings-of-pulmonary-cryptococcosis-in-immunocompetent-patients
#15
Rongshui Yang, Yan Yan, Yuhuan Wang, Xiaohuan Liu, Xinhui Su
Pulmonary cryptococcosis is most commonly reported in immunocompromised patients, whereas immunocompetent hosts are rarely affected and may be asymptomatic, resulting in reduced diagnostic performance of computed tomography (CT) imaging. Thus, the aim of the present study was to review the plain and contrast-enhanced chest CT scan findings of primary pulmonary cryptococcosis in immunocompetent patients, with the aim of improving the diagnosis of this type of pulmonary disease. In the present study, a total of 27 immunocompetent patients of clinically confirmed pulmonary cryptococcosis were analyzed retrospectively...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29099505/histological-findings-and-lung-dust-analysis-as-the-basis-for-occupational-disease-compensation-in-asbestos-related-lung-cancer-in-germany
#16
Inke Sabine Feder, Anja Theile, Andrea Tannapfel
OBJECTIVES: This study has researched the significance of histologically raised findings and lung dust analyses in the context of claiming the recognition of and thus compensation for an asbestos-associated occupational disease. MATERIAL AND METHODS: For this approach, all findings from the German Mesothelioma Register in 2015 that included lung dust analyses were evaluated and were compared with information on asbestos fiber exposure at work based on fiber years, and with the results of radiological findings...
November 2, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29093191/silica-induced-fibrosis-an-ancient-response-from-the-early-metazoans
#17
Marina Pozzolini, Sonia Scarfì, Lorenzo Gallus, Sara Ferrando, Carlo Cerrano, Marco Giovine
Exposure to crystalline silica particles causes silicosis, an occupational disease leading to an overproduction of collagen in the lung. The first step of this pathology is characterized by the release of inflammatory mediators. Tumour necrosis factor (TNF) is a pro-inflammatory cytokine directly involved in silica-induced pulmonary fibrosis. The marine demosponge Chondrosia reniformis is able to incorporate silica grains and partially dissolve the crystalline forms apparently without toxic effects. In the present work, C...
November 1, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29089391/correction-of-odds-ratios-in-case-control-studies-for-exposure-misclassification-with-partial-knowledge-of-the-degree-of-agreement-among-experts-who-assessed-exposures
#18
Igor Burstyn, Paul Gustafson, Javier Pintos, Jérôme Lavoué, Jack Siemiatycki
OBJECTIVES: Estimates of association between exposures and diseases are often distorted by error in exposure classification. When the validity of exposure assessment is known, this can be used to adjust these estimates. When exposure is assessed by experts, even if validity is not known, we sometimes have information about interrater reliability. We present a Bayesian method for translating the knowledge of interrater reliability, which is often available, into knowledge about validity, which is often needed but not directly available, and applying this to correct odds ratios (OR)...
October 31, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29089390/circulatory-disease-in-french-nuclear-fuel-cycle-workers-chronically-exposed-to-uranium-a-nested-case-control-study
#19
Sergey Zhivin, Irina Guseva Canu, Estelle Davesne, Eric Blanchardon, Jérôme-Philippe Garsi, Eric Samson, Christine Niogret, Lydia B Zablotska, Dominique Laurier
OBJECTIVES: There is growing evidence of an association between low-dose external γ-radiation and circulatory system diseases (CSDs), yet sparse data exist about an association with chronic internal uranium exposure and the role of non-radiation risk factors. We conducted a nested case-control study of French AREVA NC Pierrelatte nuclear workers employed between 1960 and 2005 to estimate CSD risks adjusting for major CSD risk factors (smoking, blood pressure, body mass index, total cholesterol and glycaemia) and external γ-radiation dose...
October 31, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29083017/pulmonary-prevention-program-in-the-proszowice-county-description-and-results
#20
Wojciech Skucha, Filip Mejza, Pawel Nastalek, Zbigniew Doniec
INTRODUCTION: In the Proszowice county, both lung cancer and chronic obstructive pulmonary disease (COPD) are more common in comparison with other regions of Poland. The purpose of this study was to provide a report on a prevention program carried out in the area to reduce the burden of COPD and lung cancer in the region. MATERIAL AND METHODS: The program consisted of the following: active prevention - questionnaire survey offered to every county inhabitant aged at least 40 and chest X-ray and spirometry performed in selected subjects; and passive prevention - covering multiple educational activities promoting healthy lifestyle...
October 30, 2017: Advances in Respiratory Medicine
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