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Tirofiban

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https://www.readbyqxmd.com/read/28424434/high-dose-bolus-tirofiban-versus-low-dose-bolus-in-patients-with-acute-coronary-syndrome-undergoing-percutaneous-coronary-intervention
#1
Taner Ulus, Utku Şenol, Senan Tahmazov, Kemal Iskenderov, Fezan Mutlu, Yüksel Çavuşoğlu
OBJECTIVE: Aim of the present study was to determine effects of high-dose versus low-dose intravenous (IV) bolus tirofiban on angiographic measures, ST resolution, enzymatic infarct size, and clinical outcomes in patients with acute coronary syndrome (ACS) who were undergoing percutaneous coronary intervention (PCI) and received current pharmacoinvasive therapy. METHODS: Acute coronary syndrome patients (n=271, 85.6% male; mean age: 57.9±12.6 years) from between 2009 and 2015 who received IV tirofiban therapy following PCI were retrospectively analyzed...
March 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28419294/preliminary-study-of-tirofiban-infusion-in-coil-embolization-of-ruptured-intracranial-aneurysms
#2
Chang Hyo Yoon, Ho-Won Lee, Young Soo Kim, Sang Won Lee, Jeong A Yeom, Jieun Roh, Seung Kug Baik
BACKGROUND: There have been some reports on the use of intra-arterial tirofiban in ruptured intracranial aneurysms, but few studies have reported on the use of 24 h of intravenous tirofiban infusion in patients with subarachnoid hemorrhage. OBJECTIVE: To present our experience with intravenous tirofiban infusion, in the form of a monotherapy as well as in addition to intra-arterial tirofiban, as a prophylactic, and as a rescue management for thrombus in patients who have undergone embolization with coils for ruptured intracranial aneurysms...
April 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28417457/effects-of-riboflavin-and-ultraviolet-light-treatment-on-platelet-thrombus-formation-and-thrombus-stability-on-collagen
#3
Chikahiro Terada, Masayuki Shiba, Tadashi Nagai, Masahiro Satake
BACKGROUND: Pathogen reduction technologies (PRTs) are considered for the implementation of safer platelet (PLT) transfusion. PRT treatment involves the addition of a photosensitizer to a blood component followed by ultraviolet (UV) light irradiation. However, the effects of PRT treatment on PLT thrombus formation and thrombus stability have not been satisfactorily clarified. STUDY DESIGN AND METHODS: Leukoreduced PLT concentrates (PCs) were treated with riboflavin and UV light (Mirasol PRT)...
April 17, 2017: Transfusion
https://www.readbyqxmd.com/read/28398400/-bioequivalence-and-excipients-the-case-of-tirofiban-a-warning-from-the-italian-society-of-interventional-cardiology-sici-gise
#4
Marianna Adamo, Roberto Bonmassari, Guglielmo Bernardi, Paola Colombo, Giovanni Esposito, Marco Ferlini, Alessio Gaetano La Manna, Ugo Limbruno, Alfredo Marchese, Ciro Mauro, Alberto Menozzi, Antonino Nicosia, Stefano Rigattieri, Giuseppe Tarantini, Fabio Tarantino, Marco Valgimigli, Ferdinando Varbella, Giuseppe Musumeci
No abstract text is available yet for this article.
February 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28386054/acute-myocardial-infarction-due-to-coronary-artery-embolism-in-a-22-year-old-woman-with-mitral-stenosis-with-atrial-fibrillation-under-warfarinization-successful-management-with-anticoagulation
#5
Santosh Kumar Sinha, Mukesh Jitendra Jha, Mahmadula Razi, Vikash Chaturvedi, Yatish Besthenahalli Erappa, Shravan Singh, Vikas Mishra, Dibbendhu Khanra, Karandeep Singh
BACKGROUND Coronary artery embolization is an exceedingly rare cause of myocardial infarction, but a few cases in association with prosthetic mechanical valves have been reported. We report a case of embolic myocardial infarction caused by a thrombus in the left atrium with deranged coagulation profile in a patient with critical mitral stenosis under warfarinization. CASE REPORT A 22-year-old woman was taken to the catheterization lab for early coronary intervention in lieu of non-ST elevation myocardial infarction...
April 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28377257/special-endovascular-treatment-for-acute-large-artery-occlusion-resulting-from-atherosclerotic-disease
#6
Ting-Yu Yi, Wen-Huo Chen, Yan-Min Wu, Mei-Fang Zhang, Yue-Hong Chen, Zong-Zhong Wu, Yan-Chuan Shi, Bai-Ling Chen
BACKGROUND: and Purpose: Acute intracranial atherosclerotic disease (IAD)-related large artery occlusion (LAO) is typically refractory to mechanical thrombectomy. We evaluated the feasibility and safety of emergency balloon-assisted or stent-assisted angioplasty performed with tirofiban administration for acute IAD-related LAO. METHODS: We identified, from among 55 consecutive patients who underwent endovascular treatment for LAO, 12 patients with acute IAD-related LAO who underwent balloon-assisted or stent-assisted angioplasty with (n = 3) or without passage of a stent retriever...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28347898/stentriever-thrombectomy-failure-a-challenge-in-stroke-management
#7
Claudio Baracchini, Filippo Farina, Matteo Soso, Federica Viaro, Silvia Favaretto, Anna Palmieri, Caterina Kulyk, Enzo Ballotta, Lorena Nico, Giacomo Cester, Francesco Causin
BACKGROUND: and Purpose: Stentriever thrombectomy failure in patients with acute ischemic stroke due to anterior circulation large artery occlusion (LAO) is not a rare event. The purpose of this study was to investigate whether other procedures (tirofiban, permanent stenting) are able to recanalize the occluded vessel and determine a better outcome without increasing mortality and intracranial hemorrhage (ICH) rates. METHODS: Among 513 patients consecutively admitted with anterior circulation stroke, 109 underwent stentriever thrombectomy...
March 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28331172/an-anti-coagulation-conundrum-implantation-of-total-artificial-heart-in-a-patient-with-heparin-induced-thrombocytopenia-type-ii
#8
Theodore J Cios, Yuliana Salamanca-Padilla, Dmitri Guvakov
BACKGROUND Heparin-induced thrombocytopenia (HIT) is a rare but life-threatening complication of heparin administration. It can present a major clinical dilemma for physicians caring for patients requiring life-saving urgent or emergent cardiac surgery. Studies have been published examining the use of alternative anticoagulants for patients undergoing cardiopulmonary bypass (CPB), however, evidence does not clearly support any particular approach. Presently, there are no large-scale, prospective randomized studies examining the impact of alternative anticoagulants on clinical outcomes for HIT-positive patients requiring cardiac surgery...
March 23, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28321019/myocardial-infarction-in-a-young-man-with-nephrotic-syndrome
#9
Zhenliang Chu, Hang Zhu, Bin Zhang, Liqin Jiang
A 26-year-old man diagnosed with nephrotic syndrome (NS) 2 years previously presented with chest pain. An electrocardiogram (ECG) performed at a local hospital showed ST-elevation in chest leads. Cardiac troponin-I was significantly positive. Echocardiography revealed mild regional wall-motion abnormalities in the heart apex. Seven days later, angiography (CAG) revealed a thrombus in the left anterior descending branch (LAD). Tirofiban was injected into the LAD for thromboclasis. ECG after CAG showed the ST-segment was much lower than before...
April 6, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28315823/corrigendum-to-validated-spectrofluorimetric-methods-for-the-determination-of-apixaban-and-tirofiban-hydrochloride-in-pharmaceutical-formulations-spectrochim-acta-a-mol-biomol-spectrosc-174-2017-326-330
#10
Ramzia I El-Bagary, Ehab F Elkady, Naira A Farid, Nadia F Youssef
No abstract text is available yet for this article.
March 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28184261/dual-antiplatelet-therapy-and-non-cardiac-surgery-evolving-issues-and-anesthetic-implications
#11
REVIEW
Jong Wook Song, Sarah Soh, Jae-Kwang Shim
Dual antiplatelet therapy (DAPT) consisting of aspirin plus a P2Y12 inhibitor (clopidogrel, prasugrel, or ticagrelor) is imperative for the treatment of acute coronary syndrome, particularly during the re-endothelialization period after percutaneous coronary intervention (PCI). When patients undergo surgery during this period, the consequences of stent thrombosis are far more serious than those of bleeding complications, except in cases of intracranial surgery. The recommendations for perioperative DAPT have changed with emerging evidence regarding the improved efficacy of non-first-generation drug (everolimus, zotarolimus)-eluting stents (DES)...
February 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/28180001/assessment-of-platelet-function-in-patients-receiving-tirofiban-early-after-primary-coronary-intervention
#12
REVIEW
Péter Kupó, Dániel Aradi, Adrienn Tornyos, Margit Tőkés-Füzesi, András Komócsi
BACKGROUND: Following percutaneous coronary intervention, combined antiplatelet therapy is necessary. Platelet function testing (PFT) has prognostic value and may be applied in the risk assessment of acute coronary syndrome. In case of combined antiplatelet therapy, PFT may require special laboratory methods, as different antiplatelet agents may influence test results. MATERIALS AND METHODS: Platelet functions were measured in stent thrombosis-segment elevation myocardial infarction patients receiving aspirin, clopidogrel, and tirofiban...
December 2016: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28169555/aspiration-thrombectomy-and-intracoronary-tirofiban-via-guideliner-%C3%A2-catheter-for-a-thrombosed-aneurysmal-vessel
#13
James Fry, Ali Naqvi, Amit Bahia, Arnold Seto
A 52-year-old Asian male with no traditional risk factors for coronary artery disease presented with acute coronary syndrome. Coronary angiography showed complete thrombotic occlusion of the left circumflex with a large thrombus burden in the setting of diffuse aneurysmal enlargement of the coronary arteries consistent with antecedent Kawasaki disease. Manual thrombectomy with adjunctive intracoronary tirofiban was performed utilizing the GuideLiner catheter. Stent implantation was deferred. Follow-up imaging 48 h later showed preserved coronary flow and decreased thrombus burden...
February 7, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28155889/platelets-protect-lung-from-injury-induced-by-systemic-inflammatory-response
#14
Shuhua Luo, Yabo Wang, Qi An, Hao Chen, Junfei Zhao, Jie Zhang, Wentong Meng, Lei Du
Systemic inflammatory responses can severely injure lungs, prompting efforts to explore how to attenuate such injury. Here we explored whether platelets can help attenuate lung injury in mice resulting from extracorporeal circulation (ECC)-induced systemic inflammatory responses. Mice were subjected to ECC for 30 min, then treated with phosphate-buffered saline, platelets, the GPIIb/IIIa inhibitor Tirofiban, or the combination of platelets and Tirofiban. Blood and lung tissues were harvested 60 min later, and lung injury and inflammatory status were assessed...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27984753/validated-spectrofluorimetric-methods-for-the-determination-of-apixaban-and-tirofiban-hydrochloride-in-pharmaceutical-formulations
#15
Ramzia I El-Bagary, Ehab F Elkady, Naira A Farid, Nadia F Youssef
Apixaban and Tirofiban Hydrochloride are low molecular weight anticoagulants. The two drugs exhibit native fluorescence that allow the development of simple and valid spectrofluorimetric methods for the determination of Apixaban at λ ex/λ em=284/450nm and tirofiban HCl at λ ex/λ em=227/300nm in aqueous media. Different experimental parameters affecting fluorescence intensities were carefully studied and optimized. The fluorescence intensity-concentration plots were linear over the ranges of 0.2-6μgml(-1) for apixaban and 0...
March 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/27982267/in-lab-upfront-use-of-tirofiban-may-reduce-the-occurrence-of-no-reflow-during-primary-percutaneous-coronary-intervention-a-pilot-randomized-study
#16
Igor Matos Lago, Gustavo Caires Novaes, André Vannucchi Badran, Rafael Brolio Pavão, Ricardo Barbosa, Geraldo Luiz de Figueiredo, Moysés de Oliveira Lima, Jorge Luiz Haddad, André Schmidt, José Antônio Marin
Background: Despite successful opening of culprit coronary artery, myocardial reperfusion does not always follows primary percutaneous coronary intervention (PPCI). Glycoprotein IIb/IIIa inhibitors are used in the treatment of no-reflow (NR), but their role to prevent it is unproven. Objective: To evaluate the effect of in-lab administration of tirofiban on the incidence of NR in ST-elevation myocardial infarction (STEMI) treated with PPCI. Methods: STEMI patients treated with PPCI were randomized (24 tirofiban and 34 placebo) in this double-blinded study to assess the impact of intravenous tirofiban on the incidence of NR after PPCI according to angiographic and electrocardiographic methods...
November 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27981920/in-silico-analysis-of-amotosalen-hydrochloride-binding-to-cd-61-of-platelets
#17
Hammad Tufail Chaudhary
OBJECTIVE: To determine the docking of Amotosalen hydrochloride (AH) at CD-61 of platelets, and to suggest the cause of bleeding in AH treated platelets transfusion. STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Medical College, Taif University, Taif, Saudi Arabia, from October 2014 to May 2015. METHODOLOGY: The study was carried out in-silico. PDB (protein data bank) code of Tirofiban bound to CD-61 was 2vdm...
November 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27899850/evaluation-of-short-and-long-term-efficacy-of-combined-intracoronary-administration-of-high-dose-adenosine-and-tirofiban-during-primary-percutaneous-coronary-intervention
#18
Yanbing Li, Qiang Li, Feiou Li, Min Zong, Guobin Miao, Xinchun Yang, Zichuan Tong, Jianjun Zhang
BACKGROUND: To assess the influence of combined intracoronary application of high-dose adenosine and tirofiban in primary percutaneous coronary intervention (PCI) on clinical events and cardiac function. METHODS: Our study evaluated consecutive patients with acute ST-segment elevation myocardial infarction undergoing primary PCI, who were randomly divided into adenosine group (n = 130) and control group (n = 128). Combined with thrombus aspiration and then intracoronary tirofiban, the adenosine group received intracoronary adenosine (2 mg) through the aspiration catheter 2 times...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27891513/clinic-predictive-factors-for-insufficient-myocardial-reperfusion-in-st-segment-elevation-myocardial-infarction-patients-treated-with-selective-aspiration-thrombectomy-during-primary-percutaneous-coronary-intervention
#19
Jinfan Tian, Yue Liu, Xiantao Song, Min Zhang, Feng Xu, Fei Yuan, Shuzheng Lyu
Background. Insufficient data are available on the potential benefit of selective aspiration and clinical predictors for no-reflow in STEMI patients undergoing primary percutaneous coronary intervention (PPCI) adjunct with aspiration thrombectomy. Objective. The aim of our study was to investigate clinical predictors for insufficient reperfusion in patients with high thrombus burden treated with PPCI and manual aspiration thrombectomy. Methods. From January 2011 till December 2015, 277 STEMI patients undergoing manual aspiration thrombectomy and PPCI were selected and 202 patients with a Thrombolysis in Myocardial Infarction (TIMI) thrombus grade 4~5 were eventually involved in our study...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27852380/-clinical-analysis-of-endovascular-strategies-in-the-treatment-of-vertebrobasilar-dissecting-aneurysms
#20
Y Z Zang, Z G Wang, C W Wang, Y Zhang, X Ding, X F Wang
Objective: To evaluate the efficacy and safety of endovascular strategies for vertebrobasilar dissecting aneurysm (VBDA) and analyze advantages and disadvantages of different endovascular methods for the treatment of VBDA through long-term follow-up. Methods: Retrospectively analyzing was used for the clinical information of 45 cases of vertebrobasilar dissecting aneurysms treated with endovascular methods in our department from January 2007 to December 2015. The treatment modalities were classified into reconstructive surgery and destructive surgery that were based on parent artery preservation...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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