keyword
https://read.qxmd.com/read/38489544/efficacy-and-safety-of-tirofiban-before-stenting-for-symptomatic-intracranial-atherosclerotic-stenosis-a-randomized-clinical-trial
#1
RANDOMIZED CONTROLLED TRIAL
Jun Zhang, Xin Huang, Guoqing Wang, Xianjun Wang, Tao Zhang, Dong Wang, Lifeng Qi, Jiye Liang, Bing Li, Jianfeng Chu, Kai Li, Lili Sun, Yun Song, Wei Zhao, Meimei Zheng, Yao Meng, Hao Yin, Wei Wang, Ju Han
BACKGROUND AND OBJECTIVES: Acute stent thrombosis (AST) is not uncommon and even catastrophic during intracranial stenting angioplasty in patients with symptomatic high-grade intracranial atherosclerotic stenosis (ICAS). The purpose of this study was to investigate whether adjuvant intravenous tirofiban before stenting could reduce the risk of AST and periprocedural ischemic stroke in patients receiving stent angioplasty for symptomatic ICAS. METHODS: A prospective, multicenter, open-label, randomized clinical trial was conducted from September 9, 2020, to February 18, 2022, at 10 medical centers in China...
April 9, 2024: Neurology
https://read.qxmd.com/read/38444355/long-circulating-nanoparticles-as-passive-targeting-nanocarriers-for-the-treatment-of-thrombosis
#2
JOURNAL ARTICLE
Junyao Li, Keqiang Lu, Shaokai Sun, Juanjuan Peng, Lingzhi Zhao
Thrombosis is the major cause of cardiovascular diseases. Only a small subset of patients could benefit from thrombolytic therapy due to the high bleeding risk brought about by the repeated administration of thrombolytic drugs. Nanoparticles with targeting ligands have been developed as nanocarriers of thrombolytic drugs to deliver the drug to the thrombus through active targeting. However, the passive targeting effect of nanoparticles on the thrombus is yet to be investigated. Herein, we prepared silica cross-linked micelles (SCLMs) with a long blood circulation half-life as drug carriers to target the thrombus through passive targeting...
March 6, 2024: Nanoscale
https://read.qxmd.com/read/38414555/the-impact-of-intraarterial-intravenous-and-combined-tirofiban-on-endovascular-treatment-for-acute-intracranial-atherosclerotic-occlusion
#3
JOURNAL ARTICLE
Zhiping Bu, Dapeng Sun, Gaoting Ma, Baixue Jia, Xu Tong, Xiaochuan Huo, Anxin Wang, Ning Ma, Feng Gao, Dapeng Mo, Ligang Song, Xuan Sun, Yiming Deng, Xiaoqing Li, Bo Wang, Gang Luo, Deguo Su, Zhongrong Miao
BACKGROUND AND PURPOSE: Adjunctive tirofiban administration in patients undergoing endovascular treatment (EVT) for acute large vessel occlusion (LVO) has been investigated in several studies. However, the findings are conflict. This study aimed to compare the effect of different administration pathways of tirofiban on patients undergoing EVT for acute LVO with intracranial atherosclerotic disease (ICAD). METHODS: Patients were selected from the ANGEL-ACT Registry (Endovascular Treatment Key Technique and Emergency Workflow Improvement of Acute Ischemic Stroke: A Prospective Multicenter Registry Study) and divided into four groups: intra-arterial (IA), intravenous (IV), and intra-arterial plus intravenous (IA+IV) and non-tirofiban...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38409912/perioperative-complications-of-arteriovenous-tirofiban-administration-versus-oral-dual-antiplatelet-therapy-for-stent-assisted-embolization-treated-aneurysmal-subarachnoid-hemorrhage-a-retrospective-controlled-cohort-analysis
#4
JOURNAL ARTICLE
Kaishan Wang, Yujie Chen, Yao Xu, Chen Yang, Zhaopan Lai, Binbin Tan, Gang Zhu, Hongping Miao
BACKGROUND: Major perioperative complications of stent-assisted embolization treated for aneurysmal subarachnoid hemorrhage patients include the formation of thromboembolic events (TEs) and hemorrhagic events (HEs), for which antiplatelet protocols play a key role. METHODS: We conducted a single-center retrospective analysis to compare the differences between arteriovenous tirofiban administration with traditional oral dual antiplatelet therapy (DAPT). A total of 417 consecutive patients were enrolled...
February 2024: Brain and Behavior
https://read.qxmd.com/read/38390817/adjunct-intraarterial-or-intravenous-tirofiban-versus-no-tirofiban-after-successful-recanalization-of-basilar-artery-occlusion-stroke-the-basilar-registry
#5
JOURNAL ARTICLE
Huagang Li, Dongsheng Ju, Zhaojun Tao, Jiayin Wang, Thanh N Nguyen, Jeffrey L Saver, Raul G Nogueira, Chang Liu, Qingwu Yang, Zhongming Qiu, Congguo Yin, Dong Sun, Shudong Liu
BACKGROUND: Approximately half of patients who achieve successful reperfusion do not achieve functional independence. The present study sought to investigate the clinical outcomes and safety of intraarterial or intravenous tirofiban as adjunct therapy in patients with acute basilar artery occlusion who had achieved successful recanalization with endovascular treatment. METHODS AND RESULTS: In the national, prospective BASILAR (Endovascular Treatment for Acute Basilar Artery Occlusion Study) registry, 458 patients who met inclusion criteria were divided into 3 groups based on tirofiban administration (no tirofiban, n=262; intravenous tirofiban, n=101; intraarterial+intravenous tirofiban, n=95)...
February 23, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38363737/cost-effectiveness-of-tirofiban-for-acute-ischemic-stroke-without-large-or-medium-sized-vessel-occlusion-a-markov-modelling-analysis-from-the-chinese-and-united-states-perspectives
#6
JOURNAL ARTICLE
Li Wang, Yuhong Zeng, Limei Zhou, Ping Xu, Xianbin Guo, Yu Xie, Junxiu Cai, Min Pan, Jie Tang, Qingtao Gong, Rong Su, Yan Liu, Yake Lou
BACKGROUND: The RESCUE BT2 trial recently showcased the efficacy of tirofiban in treating acute ischemic stroke (AIS) without large or medium-sized vessel occlusion. To further assess the value of tirofiban from the perspectives of Chinese and US healthcare system, a study was conducted to evaluate its cost-effectiveness. METHODS: A hybrid model, integrating a short-term decision tree with a long-term Markov model, was developed to assess cost-effectiveness between tirofiban and aspirin for stroke patients without large or medium-sized vessel occlusion...
2024: PloS One
https://read.qxmd.com/read/38362756/intravenous-tirofiban-versus-alteplase-before-endovascular-treatment-in-acute-ischemic-stroke-a-pooled-analysis-of-the-devt-and-rescue-bt-trials
#7
JOURNAL ARTICLE
Hongfei Sang, Zhihua Cao, Jie Du, Thanh N Nguyen, Jeffrey L Saver, An Mao, Raul G Nogueira, Zhaojun Tao, Simin Zhou, Qin Han, Dong Sun, Bo Lei, Shudong Liu, Guoyong Zeng, Congguo Yin, Dongjing Xie, Weidong Luo, Zhenglong Jin, Zhongming Qiu
BACKGROUND: The present study aimed to evaluate the efficacy and safety of intravenous tirofiban versus alteplase before endovascular treatment (EVT) in acute ischemic stroke patients with intracranial large vessel occlusion. METHODS: This was a post hoc analysis using data from 2 multicenter, randomized trials: the DEVT trial (Direct Endovascular Treatment for Large Vessel Occlusion Stroke) from May 2018 to May 2020 and the RESCUE BT trial (Intravenous Tirofiban Before Endovascular Thrombectomy for Acute Ischemic Stroke) from October 2018 to October 2021...
February 16, 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38336813/the-safety-and-efficacy-of-intra-arterial-low-dose-tirofiban-administration-during-endovascular-therapy-in-patients-with-large-ischemic-core-volume
#8
JOURNAL ARTICLE
Kwang-Chun Cho, Nak-Hoon Son, So Hyeon Gwon, Jin Wook Choi, Woo Sang Jung
This study aimed to evaluate the safety and efficacy of intra-arterial (IA) administration of low- dose tirofiban during endovascular therapy in patients with large ischemic core volumes on initial brain CT. Patients were divided into two groups based on the use of IA tirofiban. We identified 87 patients (16 and 71 patients in the tirofiban and no-tirofiban groups, respectively) with acute ischemic stroke due to intracranial artery occlusion who underwent endovascular therapy with a low Alberta Stroke Program Early CT scores (2-5)...
February 9, 2024: Scientific Reports
https://read.qxmd.com/read/38326710/adding-tirofiban-on-top-of-recombinant-tissue-plasminogen-activator-may-improve-clinical-outcome-in-acute-stroke-patients
#9
JOURNAL ARTICLE
Ruhui Liu, Zhigang Liang, Wei Li, Yan Zhan, Luyao Xu, Shaowan Yang, Guomin Zheng, Li Jiang, Liwen Xie, Zhongwen Sun, Yinbao Hu
No abstract text is available yet for this article.
January 2024: Journal of Stroke
https://read.qxmd.com/read/38300017/effects-of-solitaire-ab-stent-thrombectomy-with-tirofiban-and-butylphthalide-on-neurological-function-and-inflammatory-factors-in-acute-cerebral-infarction-patients
#10
JOURNAL ARTICLE
Le Bao, Ying Liu, Long Chen, Fei Wang, Yuzhi Zhu, Shuang Liang, Youbin Wang, Hetai Quan, Pengfei Li
BACKGROUND: Acute cerebral infarction profoundly affects patients' neurological function and quality of life. This study explores the impact of Solitaire AB stent thrombectomy, combined with tirofiban and butylphthalide, on neurological function and inflammatory factors in patients with acute cerebral infarction. METHODS: Seventy-three eligible patients treated between 2021 and 2023 were divided into a control group (Solitaire AB stent thrombectomy) and a treatment group (Solitaire AB stent thrombectomy with tirofiban and butylphthalide)...
February 1, 2024: International Journal of Neuroscience
https://read.qxmd.com/read/38299272/examining-the-efficacy-safety-and-future-prospects-of-tirofiban-in-managing-myocardial-infarction-among-diabetic-patients
#11
JOURNAL ARTICLE
Haajeera Samsudeen, V P Dharani Shrinivasan
BACKGROUND: Myocardial infarction (MI) is a leading cause of death worldwide, particularly in patients with diabetes mellitus (DM). Tirofiban, a platelet GP IIb/IIIa receptor inhibitor, has shown promise as adjunctive therapy in the emergency management of MI in diabetic patients. However, a comprehensive understanding of its use, efficacy, safety, and limitations in this patient population is necessary to optimize treatment strategies and improve patient outcomes. METHODOLOGY: This review article utilized a systematic approach to gather relevant research articles, clinical trials, and studies on the use of tirofiban in the therapy of MI in diabetic patients...
January 25, 2024: Current Diabetes Reviews
https://read.qxmd.com/read/38225640/early-tirofiban-versus-heparin-for-bridging-dual-antiplatelet-therapy-in-patients-undergoing-coronary-endarterectomy-combined-with-coronary-artery-bypass-grafting-a-multicenter-randomized-controlled-trial-protocol-the-thace-cabg-trial
#12
JOURNAL ARTICLE
Liang Chen, Ming-Xin Gao, Xin Du, Chi Wang, Wen-Yuan Yu, Hong-Li Liu, Xiao-Hang Ding, Bo-Lin Wang, Kui Zhang, Dong Xu, Zhen Han, Bao-Dong Xie, Ran Dong, Yang Yu
BACKGROUND: For complete revascularization, patients with diffuse coronary artery disease should have a coronary endarterectomy and a coronary artery bypass graft (CE-CABG). Sadly, CE can lead to a lack of endothelium, which raises the risk of thrombotic events. Even though daily dual antiplatelet therapies (DAPT) have been shown to reduce thrombotic events, the risk of perioperative thrombotic events is high during the high-risk period after CE-CABG, and there is no consistent protocol to bridge DAPT...
January 15, 2024: Trials
https://read.qxmd.com/read/38196486/clinical-study-of-edaravone-dexborneol-combined-with-tirofiban-in-treatment-of-acute-cerebral-infarction
#13
JOURNAL ARTICLE
Yuxia Mi, Zhigang Hou, Jiaqi Liu, Caixia Zhang
OBJECTIVE: To explore the clinical efficacy and safety of edaravone dexborneol combined with tirofiban in the treatment of acute cerebral infarction. METHODS: This is a retrospective study. A total of 80 patients with acute cerebral infarction (ACI) treated in Cangzhou People's Hospital from March 2018 to December 2021 were selected, and randomly divided into the routine group(n=40) and intervention group(n=40) according to the principle of random draw. Neurological deficits in the two groups were evaluated and compared before and after treatment using the National Institutes of Health Stroke Scale (NIHSS)...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38196129/early-tirofiban-administration-after-intravenous-thrombolysis-in-acute-ischemic-stroke-advent-study-protocol-of-a-multicenter-randomized-double-blind-placebo-controlled-clinical-trial
#14
JOURNAL ARTICLE
Zhen-Ni Guo, Ke-Jia Zhang, Peng Zhang, Yang Qu, Reziya Abuduxukuer, Thanh N Nguyen, Hui-Sheng Chen, Yi Yang
BACKGROUND: Nearly half of patients with acute ischemic stroke who undergo intravenous thrombolysis (IVT) fail to achieve excellent functional outcomes. Early administration of tirofiban after IVT may improve patient outcomes. OBJECTIVE: To evaluate the efficacy and safety of early tirofiban administration after intravenous tenecteplase in patients with acute ischemic stroke. METHODS AND DESIGN: The ADVENT trial is a multicenter, randomized, parallel-controlled, double-blind clinical trial...
January 9, 2024: European Stroke Journal
https://read.qxmd.com/read/38195586/statistical-analysis-plan-for-the-multicenter-open-randomized-controlled-clinical-trial-to-assess-the-efficacy-and-safety-of-intravenous-tirofiban-vs-aspirin-in-acute-ischemic-stroke-due-to-tandem-lesion-undergoing-recanalization-therapy-by-endovascular-treatment
#15
JOURNAL ARTICLE
Elena Zapata-Arriaza, Manuel Medina-Rodríguez, Francisco Moniche Álvarez, Asier de Albóniga-Chindurza, Marta Aguilar-Pérez, Leire Ainz-Gómez, Pablo Baena-Palomino, Aynara Zamora, Blanca Pardo-Galiana, Fernando Delgado-Acosta, Roberto Valverde Moyano, Elvira Jiménez-Gómez, Isabel Bravo Rey, Rafael Oteros Fernández, Irene Escudero-Martínez, Isabel Vielba-Gomez, Lluis Morales Caba, Jose Díaz Pérez, Estefania García Molina, Sonia Mosteiro, María Del Mar Castellanos Rodrigo, Laura Amaya Pascasio, Carlos Hidalgo, María Del Mar Freijo Guerrero, Eva González Díaz, Jose María Ramírez Moreno, Luis Fernández Prudencio, Mikel Terceño Izaga, Saima Bashir Viturro, Miguel Ángel Gamero-García, Silvia Jiménez Jorge, Clara Rosso Fernández, Joan Montaner, Alejandro González García
RATIONALE: In-stent reocclusion after endovascular therapy has a negative impact on outcomes in acute ischemic stroke (AIS) due to tandem lesions (TL). Optimal antiplatelet therapy approach in these patients to avoid in-stent reocclusion is yet to be elucidated. AIMS: To assess efficacy and safety of intravenous tirofiban versus intravenous aspirin in patients undergoing MT plus carotid stenting in the setting of AIS due to TL. SAMPLE SIZE ESTIMATES: Two hundred forty patients will be enrolled, 120 in every treatment arm...
January 9, 2024: Trials
https://read.qxmd.com/read/38172252/use-of-tirofiban-in-endovascular-thrombectomy-more-questions-than-answers
#16
EDITORIAL
Bonaventure Ip, Hao Wang, Simon Chun Ho Yu
No abstract text is available yet for this article.
January 3, 2024: Cardiovascular and Interventional Radiology
https://read.qxmd.com/read/38166398/efficacy-and-safety-of-a-pharmaco-invasive-strategy-using-half-dose-recombinant-human-prourokinase-in-patients-with-st-segment-elevation-myocardial-infarction-during-hospitalization
#17
JOURNAL ARTICLE
Jie Dou, Jie Gao, Huihui Yang, Ruoling Guo, Chao Jiang, Jingtao Guo, Donglei Luo
This study investigated the efficacy and safety of pharmaco-invasive strategy with half-dose recombinant human prourokinase (PHDP) during hospitalization for patients with ST-segment elevation myocardial infarction (STEMI) to provide references for the treatment of STEMI. Patients with STEMI who fulfilled the inclusion and exclusion criteria and attended Chengde Central Hospital, Hebei Province, China, between September 3, 2019, and December 28, 2021, were included in this study. The experimental group received PHDP and the control group underwent primary percutaneous coronary intervention (PPCI)...
2024: Clinical and Applied Thrombosis/hemostasis
https://read.qxmd.com/read/38156359/effects-of-tirofiban-on-large-vessel-occlusion-stroke-are-modified-by-etiology-and-renal-function
#18
JOURNAL ARTICLE
Chang Liu, Fengli Li, Liyuan Chen, Jiacheng Huang, Hongfei Sang, Thanh N Nguyen, Jeffrey L Saver, Mohamad Abdalkader, Weiling Kong, Jie Yang, Changwei Guo, Chen Gong, Liping Huang, Yanzhu Pan, Xinxin Wang, Yangmei Chen, Zhongming Qiu, Wenjie Zi
OBJECTIVE: Renal function can modify the outcomes of large vessel occlusion (LVO) stroke across stroke etiologies in disparate degrees. The presence of renal function deficit can also impair the pharmacokinetics of tirofiban. Hence, this study aimed to investigate the roles of renal function in determining efficacy and safety of intravenous tirofiban before endovascular treatment (EVT) for acute ischemic stroke patients with large vessel occlusion (LVO). METHODS: This study was a post hoc exploratory analysis of the RESCUE-BT trial...
December 29, 2023: Annals of Clinical and Translational Neurology
https://read.qxmd.com/read/38143693/adverse-drug-effect-profiles-of-gp2b-3a-inhibitors-a-comparative-review-of-the-last-two-decades
#19
REVIEW
Naziha Hasan, Walter Jauregui, Mahrukh Zubair, Venugopala K Pushparajan, Bryan J Carson, Durga Manaswini Attaluri, Diny Dixon, Aman Jaisinghani, Andres Chuecos, Deepika Ravichandran
ST-Elevation Myocardial Infarction and non-ST Elevation Myocardial Infarction belong to the acute coronary syndrome group of diseases. These conditions are characterized by the complete or partial blockage of one or several coronary arteries, resulting in myocardial injury or necrosis. Various medications are used in their treatment, with the most recent addition being Glycoprotein IIb/IIIa inhibitors. They work by hindering the activity of glycoprotein IIb/IIIa receptors, which, in turn, prevents the clumping of platelets...
November 2023: Curēus
https://read.qxmd.com/read/38132509/unraveling-the-mechanism-of-platelet-aggregation-suppression-by-thioterpenoids-molecular-docking-and-in-vivo-antiaggregant-activity
#20
JOURNAL ARTICLE
Liliya E Nikitina, Pavel S Bocharov, Alexander A Ksenofontov, Elena V Antina, Ilmir R Gilfanov, Roman S Pavelyev, Olga V Ostolopovskaya, Inna V Fedyunina, Zulfiya R Azizova, Svetlana V Pestova, Evgeniy S Izmest'ev, Svetlana A Rubtsova, Sergei V Boichuk, Aigul R Galembikova, Elena A Smolyarchuk, Ilshat G Mustafin, Airat R Kayumov, Aleksandr V Samorodov
Natural monoterpenes and their derivatives are widely considered the effective ingredients for the design and production of novel biologically active compounds. In this study, by using the molecular docking technique, we examined the effects of two series of "sulfide-sulfoxide-sulfone" thioterpenoids containing different (e.g., bornane and pinane) monoterpene skeletons on the platelet's aggregation. Our data revealed that all the synthesized compounds exhibit inhibitory activities on platelet aggregation. For example, compound 1 effectively inhibited platelet activation and demonstrated direct binding with CD61 integrin, a well-known platelet GPIIb-IIIa receptor on platelets...
November 27, 2023: Biomimetics
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