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https://www.readbyqxmd.com/read/29126017/epidermal-growth-factor-receptor-overexpression-and-outcomes-in-early-breast-cancer-a-systematic-review-and-a-meta-analysis
#1
REVIEW
Galileo A Gonzalez-Conchas, Laura Rodriguez-Romo, David Hernandez-Barajas, Juan F Gonzalez-Guerrero, Ivan A Rodriguez-Fernandez, Adrian Verdines-Perez, Arnoud J Templeton, Alberto Ocana, Bostjan Seruga, Ian F Tannock, Eitan Amir, Francisco E Vera-Badillo
BACKGROUND: The epidermal growth factor receptor (EGFR) is a member of the ErbB family of membrane tyrosine-kinase receptors. Studies exploring the prognostic role of EGFR-overexpression in early breast cancer have shown variable results, and the true prognostic value of EGFR is unknown. METHODS: A systematic review of identified publications exploring the association between EGFR-overexpression (as defined from different techniques and cut-offs) and outcomes [disease-free (DFS) and, overall survival (OS)] in women with early breast cancer...
October 31, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29042633/catsper1-promoter-is-bidirectional-and-regulates-the-expression-of-a-novel-lncrna
#2
Salma E Jiménez-Badillo, Norma Oviedo, Christian Hernández-Guzmán, Lorenza González-Mariscal, Javier Hernández-Sánchez
The Catsper1 gene, whose expression is restricted to male germ cells, has great importance in reproductive biology because of its function in sperm motility and fertilization. We previously reported that the promoter of this gene has transcriptional activity in either direction in a heterologous system. In the present study, we found that the Catsper1 promoter has in vitro transcriptional activity in either orientation in GC-1 spg mouse spermatogonial cells. The results also showed that this promoter regulates the expression of a new divergent Catsper1 gene named Catsper1au (Catsper1 antisense upstream transcript)...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28981450/determinant-factors-of-physical-performance-and-specific-throwing-in-handball-players-of-different-ages
#3
Manuel Ortega-Becerra, Fernando Pareja-Blanco, Pedro Jiménez-Reyes, Víctor Cuadrado-Peñafiel, Juan José González-Badillo
This study aimed to analyze various fitness qualities in handball players of different ages, and to determine the relationships between these parameters and throwing velocity. Forty-four handball players participated, pooled by age groups: ELITE (n = 13); under-18 (U18, n = 16); under-16 (U16, n = 15). The following tests were completed: 20-m running sprints; countermovement jumps (CMJ); jump squat to determine the load that elicited ∼20 cm jump height (JSLOAD-20cm); a progressive loading test in full-squat and bench-press to determine the load that elicited ∼1 m·s (SQ-V1-LOAD and BP-V1-LOAD), and handball throwing (Jump Throw and 3-Step Throw)...
June 2, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28965198/time-course-of-recovery-following-resistance-training-leading-or-not-to-failure
#4
Ricardo Morán-Navarro, Carlos E Pérez, Ricardo Mora-Rodríguez, Ernesto de la Cruz-Sánchez, Juan José González-Badillo, Luis Sánchez-Medina, Jesús G Pallarés
PURPOSE: To describe the acute and delayed time course of recovery following resistance training (RT) protocols differing in the number of repetitions (R) performed in each set (S) out of the maximum possible number (P). METHODS: Ten resistance-trained men undertook three RT protocols [S × R(P)]: (1) 3 × 5(10), (2) 6 × 5(10), and (3) 3 × 10(10) in the bench press (BP) and full squat (SQ) exercises. Selected mechanical and biochemical variables were assessed at seven time points (from - 12 h to + 72 h post-exercise)...
December 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28912725/enhanced-strength-and-sprint-levels-and-changes-in-blood-parameters-during-a-complete-athletics-season-in-800-m-high-level-athletes
#5
Beatriz Bachero-Mena, Fernando Pareja-Blanco, Juan J González-Badillo
The purpose of this study was to analyze changes in sprint, strength, hematological, and hormonal parameters in high-level 800 m athletes during a complete athletics season. Thirteen male athletes of national and international level in 800 m (personal best ranging from 1:43 to 1:58 min:ss) participated in this study. A total of 5 tests were conducted during a complete athletics season. Athletes performed sprint tests (20 and 200 m), countermovement jump (CMJ), jump squat (JS), and full squat (SQ) tests. Blood samples (red and white blood profile) and hormones were collected in test 1 (T1), test 3 (T3), and test 5 (T5)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28828089/relationships-between-sprint-jumping-and-strength-abilities-and-800-m-performance-in-male-athletes-of-national-and-international-levels
#6
Beatriz Bachero-Mena, Fernando Pareja-Blanco, David Rodríguez-Rosell, Juan Manuel Yáñez-García, Ricardo Mora-Custodio, Juan José González-Badillo
This study analysed the relationships between sprinting, jumping and strength abilities, with regard to 800 m running performance. Fourteen athletes of national and international levels in 800 m (personal best: 1:43-1:58 min:ss) completed sprint tests (20 m and 200 m), a countermovement jump, jump squat and full squat test as well as an 800 m race. Significant relationships (p < 0.01) were observed between 800 m performance and sprint tests: 20 m (r = 0.72) and 200 m (r = 0.84). Analysing the 200 m run, the magnitude of the relationship between the first to the last 50 m interval times and the 800 m time tended to increase (1st 50 m: r = 0...
September 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28828074/determinant-factors-of-the-squat-jump-in-sprinting-and-jumping-athletes
#7
Juan José González-Badillo, Pedro Jiménez-Reyes, Jorge Ramírez-Lechuga
The aim of this study was to assess the relationship between strength variables and maximum velocity (Vmax) in the squat jump (SJ) in sprinting and jumping athletes. Thirty-two sprinting and jumping athletes of national level (25.4 ± 4.5 years; 79.4 ± 6.9 kg and 180.4 ± 6.0 cm) participated in the study. Vmax in the SJ showed significant relationships with peak force 1 (PF1) (r = 0.82, p ≤ 0.001), peak force 2 (PF2) (r = 0.68, p ≤ 0.001), PF2 by controlling for PF1 (r = 0.30, non-significant), the maximum rate of force development at peak force 1 (RFDmax1) (r = 0...
September 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28755836/influenza-seasonality-goes-south-in-the-yucatan-peninsula-the-case-for-a-different-influenza-vaccine-calendar-in-this-mexican-region
#8
Guadalupe Ayora-Talavera, Gerardo Montalvo-Zurbia Flores, Jesus Gómez-Carballo, Refugio González-Losa, Laura Conde-Ferraez, Marylin Puerto-Solís, Irma López-Martínez, Alberto Díaz-Quiñonez, Gisela Barrera-Badillo, Rodolfo Acuna-Soto, Alicia A Livinski, Wladimir J Alonso
INTRODUCTION: While vaccination may be relatively straightforward for regions with a well-defined winter season, the situation is quite different for tropical regions. Influenza activity in tropical regions might be out of phase with the dynamics predicted for their hemispheric group thereby impacting the effectiveness of the immunization campaign. OBJECTIVE: To investigate how the climatic diversity of Mexico hinders its existing influenza immunization strategy and to suggest that the hemispheric vaccine recommendations be tailored to the regional level in order to optimize vaccine effectiveness...
July 26, 2017: Vaccine
https://www.readbyqxmd.com/read/28721552/high-plasma-adenosine-levels-in-overweight-obese-pregnant-women
#9
Priscila Badillo, Paola Salgado, Patricia Bravo, Katherine Guevara, Jesenia Acurio, Maria Angelica Gonzalez, Carlos Oyarzun, Rody San Martin, Carlos Escudero
We aim to investigate whether overweight/obese pregnant women have elevated plasma levels of adenosine associated with increased consumption of high-calorie food. Sixty women were included. They were divided into lean (n = 23 and n = 12) or overweight/obese (n = 7 and n = 18) non-pregnant and pregnant women, respectively. Clinical records and maternal blood samples were collected after informed consent. A self-reported dietary questionnaire was also completed. Plasma adenosine levels were determined with high-performance liquid chromatography...
July 18, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28717206/an-amino-acid-signature-associated-with-obesity-predicts-2-year-risk-of-hypertriglyceridemia-in-school-age-children
#10
Sofia Moran-Ramos, Elvira Ocampo-Medina, Ruth Gutierrez-Aguilar, Luis Macías-Kauffer, Hugo Villamil-Ramírez, Blanca E López-Contreras, Paola León-Mimila, Joel Vega-Badillo, Roxana Gutierrez-Vidal, Ricardo Villarruel-Vazquez, Erandi Serrano-Carbajal, Blanca E Del-Río-Navarro, Adriana Huertas-Vázquez, Teresa Villarreal-Molina, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Carlos A Aguilar-Salinas, Samuel Canizales-Quinteros
Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets to promote early intervention beginning in school age. Thus, we aimed to identify metabolomic profiles associated with obesity and obesity-related metabolic traits. We used data from the Obesity Research Study for Mexican children (ORSMEC) in Mexico City and included a case control (n = 1120), cross-sectional (n = 554) and a longitudinal study (n = 301) of 6-12-year-old children...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28648414/prognostic-role-of-ki-67-score-in-localized-prostate-cancer-a-systematic-review-and-meta-analysis
#11
REVIEW
Alejandro Berlin, Julio F Castro-Mesta, Laura Rodriguez-Romo, David Hernandez-Barajas, Juan F González-Guerrero, Iván A Rodríguez-Fernández, Galileo González-Conchas, Adrian Verdines-Perez, Francisco E Vera-Badillo
BACKGROUND: Ki-67 for quantifying tumor proliferation is widely used. In localized prostate cancer (PCa), despite a suggested predictive role of Ki-67 for outcomes after therapies, it has not been incorporated into clinical practice. Herein, we conduct a systematic review and meta-analysis of the literature reporting the association of Ki-67 and disease outcomes in PCa treated radically. METHODS: Medline and EMBASE databases were searched without date or language restrictions, using "KI67" and "prostate cancer" MeSH terms...
June 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28588448/structural-changes-of-amyloid-beta-in-hippocampus-of-rats-exposed-to-ozone-a-raman-spectroscopy-study
#12
Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Isidro Badillo-Ramírez, Ulises López-González, José M Saniger
The aim of this work was to study the effect of oxidative stress on the structural changes of the secondary peptide structure of amyloid beta 1-42 (Aβ 1-42), in the dentate gyrus of hippocampus of rats exposed to low doses of ozone. The animals were exposed to ozone-free air (control group) and 0.25 ppm ozone during 7, 15, 30, 60, and 90 days, respectively. The samples were studied by: (1) Raman spectroscopy to detect the global conformational changes in peptides with α-helix and β-sheet secondary structure, following the deconvolution profile of the amide I band; and (2) immunohistochemistry against Aβ 1-42...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28465094/enhancement-of-vp6-immunogenicity-and-protective-efficacy-against-rotavirus-by-vp2-in-a-genetic-immunization
#13
D V Lopez-Guerrero, N Arias, L Gutierrez-Xicotencatl, L Chihu-Amparan, A González, A Pedroza-Saavedra, G Rosas-Salgado, J C Villegas-Garcia, O Badillo-Godinez, G Fernandez, S Lopez, F Esquivel-Guadarrama
VP2/VP6 virus like particles (VLPs) are very effective in inducing protection against the rotavirus infection in animal models. Individually, VP6 can also induce protection. However, there is no information about the immunogenicity of VP2. The aim of this work was to evaluate the efficacy of DNA vaccines codifying for VP2 or VP6, alone or combined, to induce protection against the rotavirus infection. Murine rotavirus VP2 and VP6 genes were cloned into the pcDNA3 vector. Adult BALB/c mice were inoculated three times by intramuscular (i...
April 29, 2017: Vaccine
https://www.readbyqxmd.com/read/28338365/movement-velocity-as-indicator-of-relative-intensity-and-level-of-effort-attained-during-the-set-in-pull-up-exercise
#14
Miguel Sánchez-Moreno, David Rodríguez-Rosell, Fernando Pareja-Blanco, Ricardo Mora-Custodio, Juan José González-Badillo
PURPOSE: to analyze the relationship between movement velocity and relative load (%1RM) in the pull-up exercise (PU), and to determine the pattern of repetition velocity loss during a single set to failure in pulling one's own body mass. METHODS: Fifty-two men (age = 26.5 ± 3.9 years, body mass = 74.3 ± 7.2 kg) performed a first evaluation (T1) consisting of an one-repetition maximum test (1RM), and a test of maximum number of repetitions to failure pulling one's own body mass (MNR) in the PU exercise...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28237027/cholesterol-plays-a-larger-role-during-mycobacterium-tuberculosis-in%C3%A2-vitro-dormancy-and-reactivation-than-previously-suspected
#15
Maria D Soto-Ramirez, Diana A Aguilar-Ayala, Lazaro Garcia-Morales, Sofia M Rodriguez-Peredo, Claudia Badillo-Lopez, Diana E Rios-Muñiz, Mario A Meza-Segura, Gelen Y Rivera-Morales, Lizbel Leon-Solis, Jorge F Cerna-Cortes, Sandra Rivera-Gutierrez, Addy C Helguera-Repetto, Jorge A Gonzalez-Y-Merchand
It is known that cholesterol plays a key role for Mycobacterium tuberculosis (Mtb) adaptation and survival within the host, thus contributing to the establishment of dormancy. It has been extensively demonstrated that fatty acids are the main energy source of Mtb during infection and dormancy, and it has been proposed that these molecules are implicated in reactivation of bacilli from a dormant state. We used in vitro models to analyze Mtb gene expression during dormancy and reactivation when fatty acids and cholesterol are the unique carbon source in the media...
March 2017: Tuberculosis
https://www.readbyqxmd.com/read/28192832/velocity-loss-as-a-variable-for-monitoring-resistance-exercise
#16
Juan José González-Badillo, Juan Manuel Yañez-García, Ricardo Mora-Custodio, David Rodríguez-Rosell
This study aimed to analyze: 1) the pattern of repetition velocity decline during a single set to failure against different submaximal loads (50-85% 1RM) in the bench press exercise; and 2) the reliability of the percentage of performed repetitions, with respect to the maximum possible number that can be completed, when different magnitudes of velocity loss have been reached within each set. Twenty-two men performed 8 tests of maximum number of repetitions (MNR) against loads of 50-55-60-65-70-75-80-85% 1RM, in random order, every 6-7 days...
March 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28169153/effects-of-light-load-maximal-lifting-velocity-weight-training-vs-combined-weight-training-and-plyometrics-on-sprint-vertical-jump-and-strength-performance-in-adult-soccer-players
#17
David Rodríguez-Rosell, Julio Torres-Torrelo, Felipe Franco-Márquez, José Manuel González-Suárez, Juan José González-Badillo
OBJECTIVES: The purpose of this study was to compare the effects of combined light-load maximal lifting velocity weight training (WT) and plyometric training (PT) with WT alone on strength, jump and sprint performance in semiprofessional soccer players. DESIGN: Experimental, pre-post tests measures. METHODS: Thirty adult soccer players were randomly assigned into three groups: WT alone (FSG, n=10), WT combined to jump and sprint exercises (COM, n=10) and control group (CG, n=10)...
January 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28066847/an-efficient-ugi-3cr-aza-diels-alder-pomeranz-fritsch-protocol-towards-novel-aza-analogues-of-%C3%A2-nuevamine-%C3%A2-lennoxamine-and-magallanesine-a-diversity-oriented-synthesis-approach
#18
Óscar Vázquez-Vera, Jorge S Sánchez-Badillo, Alejandro Islas-Jácome, Manuel A Rentería-Gómez, Shrikant G Pharande, Carlos J Cortes-García, Mónica A Rincón-Guevara, Ilich A Ibarra, Rocío Gámez-Montaño, Eduardo González-Zamora
A rapid and efficient synthesis of a series of (±)-nuevamine, (±)-lennoxamine and magallanesine aza analogues is described. The synthetic strategy involves Ugi-3CR and two further condensation processes, aza-Diels-Alder cycloaddition and the Pomeranz-Fritsch reaction. The variation of the chain-size in aldehyde moieties provided structural diversity in only two operational reaction steps.
January 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28031763/evolution-of-determinant-factors-of-repeated-sprint-ability
#19
Fernando Pareja-Blanco, Luis Suarez-Arrones, David Rodríguez-Rosell, Manuel López-Segovia, Pedro Jiménez-Reyes, Beatriz Bachero-Mena, Juan José González-Badillo
The aim of this study was to investigate the changes in the relationships between repeated sprint ability (RSA) and anthropometric measures as well as fitness qualities in soccer players. Twenty-one professional soccer players performed several anthropometric and physical tests including countermovement vertical jumps (CMJs), a straight-line 30 m sprint (T30), an RSA test (6 x 20 + 20 m with 20 s recovery), a progressive isoinertial loading test in a full squat, a Yo-Yo Intermittent Recovery Test Level-1 (YYIRT-1) and a 20 m shuttle run test (20mSRT)...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/27880917/phenotypic-and-interaction-profiling-of-the-human-phosphatases-identifies-diverse-mitotic-regulators
#20
Nicole St-Denis, Gagan D Gupta, Zhen Yuan Lin, Beatriz Gonzalez-Badillo, Amanda O Veri, James D R Knight, Dushyandi Rajendran, Amber L Couzens, Ko W Currie, Johnny M Tkach, Sally W T Cheung, Laurence Pelletier, Anne-Claude Gingras
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence interactions (1,104 previously unreported), implicating these phosphatases in the regulation of a variety of cellular processes...
November 22, 2016: Cell Reports
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