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https://www.readbyqxmd.com/read/28721552/high-plasma-adenosine-levels-in-overweight-obese-pregnant-women
#1
Priscila Badillo, Paola Salgado, Patricia Bravo, Katherine Guevara, Jesenia Acurio, Maria Angelica Gonzalez, Carlos Oyarzun, Rody San Martin, Carlos Escudero
We aim to investigate whether overweight/obese pregnant women have elevated plasma levels of adenosine associated with increased consumption of high-calorie food. Sixty women were included. They were divided into lean (n = 23 and n = 12) or overweight/obese (n = 7 and n = 18) non-pregnant and pregnant women, respectively. Clinical records and maternal blood samples were collected after informed consent. A self-reported dietary questionnaire was also completed. Plasma adenosine levels were determined with high-performance liquid chromatography...
July 18, 2017: Purinergic Signalling
https://www.readbyqxmd.com/read/28717206/an-amino-acid-signature-associated-with-obesity-predicts-2-year-risk-of-hypertriglyceridemia-in-school-age-children
#2
Sofia Moran-Ramos, Elvira Ocampo-Medina, Ruth Gutierrez-Aguilar, Luis Macías-Kauffer, Hugo Villamil-Ramírez, Blanca E López-Contreras, Paola León-Mimila, Joel Vega-Badillo, Roxana Gutierrez-Vidal, Ricardo Villarruel-Vazquez, Erandi Serrano-Carbajal, Blanca E Del-Río-Navarro, Adriana Huertas-Vázquez, Teresa Villarreal-Molina, Isabel Ibarra-Gonzalez, Marcela Vela-Amieva, Carlos A Aguilar-Salinas, Samuel Canizales-Quinteros
Childhood obesity is associated with a number of metabolic abnormalities leading to increased cardiovascular risk. Metabolites can be useful as early biomarkers and new targets to promote early intervention beginning in school age. Thus, we aimed to identify metabolomic profiles associated with obesity and obesity-related metabolic traits. We used data from the Obesity Research Study for Mexican children (ORSMEC) in Mexico City and included a case control (n = 1120), cross-sectional (n = 554) and a longitudinal study (n = 301) of 6-12-year-old children...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28648414/prognostic-role-of-ki-67-score-in-localized-prostate-cancer-a-systematic-review-and-meta-analysis
#3
REVIEW
Alejandro Berlin, Julio F Castro-Mesta, Laura Rodriguez-Romo, David Hernandez-Barajas, Juan F González-Guerrero, Iván A Rodríguez-Fernández, Galileo González-Conchas, Adrian Verdines-Perez, Francisco E Vera-Badillo
BACKGROUND: Ki-67 for quantifying tumor proliferation is widely used. In localized prostate cancer (PCa), despite a suggested predictive role of Ki-67 for outcomes after therapies, it has not been incorporated into clinical practice. Herein, we conduct a systematic review and meta-analysis of the literature reporting the association of Ki-67 and disease outcomes in PCa treated radically. METHODS: Medline and EMBASE databases were searched without date or language restrictions, using "KI67" and "prostate cancer" MeSH terms...
June 22, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28588448/structural-changes-of-amyloid-beta-in-hippocampus-of-rats-exposed-to-ozone-a-raman-spectroscopy-study
#4
Selva Rivas-Arancibia, Erika Rodríguez-Martínez, Isidro Badillo-Ramírez, Ulises López-González, José M Saniger
The aim of this work was to study the effect of oxidative stress on the structural changes of the secondary peptide structure of amyloid beta 1-42 (Aβ 1-42), in the dentate gyrus of hippocampus of rats exposed to low doses of ozone. The animals were exposed to ozone-free air (control group) and 0.25 ppm ozone during 7, 15, 30, 60, and 90 days, respectively. The samples were studied by: (1) Raman spectroscopy to detect the global conformational changes in peptides with α-helix and β-sheet secondary structure, following the deconvolution profile of the amide I band; and (2) immunohistochemistry against Aβ 1-42...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28465094/enhancement-of-vp6-immunogenicity-and-protective-efficacy-against-rotavirus-by-vp2-in-a-genetic-immunization
#5
D V Lopez-Guerrero, N Arias, L Gutierrez-Xicotencatl, L Chihu-Amparan, A González, A Pedroza-Saavedra, G Rosas-Salgado, J C Villegas-Garcia, O Badillo-Godinez, G Fernandez, S Lopez, F Esquivel-Guadarrama
VP2/VP6 virus like particles (VLPs) are very effective in inducing protection against the rotavirus infection in animal models. Individually, VP6 can also induce protection. However, there is no information about the immunogenicity of VP2. The aim of this work was to evaluate the efficacy of DNA vaccines codifying for VP2 or VP6, alone or combined, to induce protection against the rotavirus infection. Murine rotavirus VP2 and VP6 genes were cloned into the pcDNA3 vector. Adult BALB/c mice were inoculated three times by intramuscular (i...
April 29, 2017: Vaccine
https://www.readbyqxmd.com/read/28338365/movement-velocity-as-indicator-of-relative-intensity-and-level-of-effort-attained-during-the-set-in-pull-up-exercise
#6
Miguel Sánchez-Moreno, David Rodríguez-Rosell, Fernando Pareja-Blanco, Ricardo Mora-Custodio, Juan José González-Badillo
PURPOSE: to analyze the relationship between movement velocity and relative load (%1RM) in the pull-up exercise (PU), and to determine the pattern of repetition velocity loss during a single set to failure in pulling one's own body mass. METHODS: Fifty-two men (age = 26.5 ± 3.9 years, body mass = 74.3 ± 7.2 kg) performed a first evaluation (T1) consisting of an one-repetition maximum test (1RM), and a test of maximum number of repetitions to failure pulling one's own body mass (MNR) in the PU exercise...
March 24, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28237027/cholesterol-plays-a-larger-role-during-mycobacterium-tuberculosis-in%C3%A2-vitro-dormancy-and-reactivation-than-previously-suspected
#7
Maria D Soto-Ramirez, Diana A Aguilar-Ayala, Lazaro Garcia-Morales, Sofia M Rodriguez-Peredo, Claudia Badillo-Lopez, Diana E Rios-Muñiz, Mario A Meza-Segura, Gelen Y Rivera-Morales, Lizbel Leon-Solis, Jorge F Cerna-Cortes, Sandra Rivera-Gutierrez, Addy C Helguera-Repetto, Jorge A Gonzalez-Y-Merchand
It is known that cholesterol plays a key role for Mycobacterium tuberculosis (Mtb) adaptation and survival within the host, thus contributing to the establishment of dormancy. It has been extensively demonstrated that fatty acids are the main energy source of Mtb during infection and dormancy, and it has been proposed that these molecules are implicated in reactivation of bacilli from a dormant state. We used in vitro models to analyze Mtb gene expression during dormancy and reactivation when fatty acids and cholesterol are the unique carbon source in the media...
March 2017: Tuberculosis
https://www.readbyqxmd.com/read/28192832/velocity-loss-as-a-variable-for-monitoring-resistance-exercise
#8
Juan José González-Badillo, Juan Manuel Yañez-García, Ricardo Mora-Custodio, David Rodríguez-Rosell
This study aimed to analyze: 1) the pattern of repetition velocity decline during a single set to failure against different submaximal loads (50-85% 1RM) in the bench press exercise; and 2) the reliability of the percentage of performed repetitions, with respect to the maximum possible number that can be completed, when different magnitudes of velocity loss have been reached within each set. Twenty-two men performed 8 tests of maximum number of repetitions (MNR) against loads of 50-55-60-65-70-75-80-85% 1RM, in random order, every 6-7 days...
March 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28169153/effects-of-light-load-maximal-lifting-velocity-weight-training-vs-combined-weight-training-and-plyometrics-on-sprint-vertical-jump-and-strength-performance-in-adult-soccer-players
#9
David Rodríguez-Rosell, Julio Torres-Torrelo, Felipe Franco-Márquez, José Manuel González-Suárez, Juan José González-Badillo
OBJECTIVES: The purpose of this study was to compare the effects of combined light-load maximal lifting velocity weight training (WT) and plyometric training (PT) with WT alone on strength, jump and sprint performance in semiprofessional soccer players. DESIGN: Experimental, pre-post tests measures. METHODS: Thirty adult soccer players were randomly assigned into three groups: WT alone (FSG, n=10), WT combined to jump and sprint exercises (COM, n=10) and control group (CG, n=10)...
January 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28066847/an-efficient-ugi-3cr-aza-diels-alder-pomeranz-fritsch-protocol-towards-novel-aza-analogues-of-%C3%A2-nuevamine-%C3%A2-lennoxamine-and-magallanesine-a-diversity-oriented-synthesis-approach
#10
Óscar Vázquez-Vera, Jorge S Sánchez-Badillo, Alejandro Islas-Jácome, Manuel A Rentería-Gómez, Shrikant G Pharande, Carlos J Cortes-García, Mónica A Rincón-Guevara, Ilich A Ibarra, Rocío Gámez-Montaño, Eduardo González-Zamora
A rapid and efficient synthesis of a series of (±)-nuevamine, (±)-lennoxamine and magallanesine aza analogues is described. The synthetic strategy involves Ugi-3CR and two further condensation processes, aza-Diels-Alder cycloaddition and the Pomeranz-Fritsch reaction. The variation of the chain-size in aldehyde moieties provided structural diversity in only two operational reaction steps.
January 9, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28031763/evolution-of-determinant-factors-of-repeated-sprint-ability
#11
Fernando Pareja-Blanco, Luis Suarez-Arrones, David Rodríguez-Rosell, Manuel López-Segovia, Pedro Jiménez-Reyes, Beatriz Bachero-Mena, Juan José González-Badillo
The aim of this study was to investigate the changes in the relationships between repeated sprint ability (RSA) and anthropometric measures as well as fitness qualities in soccer players. Twenty-one professional soccer players performed several anthropometric and physical tests including countermovement vertical jumps (CMJs), a straight-line 30 m sprint (T30), an RSA test (6 x 20 + 20 m with 20 s recovery), a progressive isoinertial loading test in a full squat, a Yo-Yo Intermittent Recovery Test Level-1 (YYIRT-1) and a 20 m shuttle run test (20mSRT)...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/27880917/phenotypic-and-interaction-profiling-of-the-human-phosphatases-identifies-diverse-mitotic-regulators
#12
Nicole St-Denis, Gagan D Gupta, Zhen Yuan Lin, Beatriz Gonzalez-Badillo, Amanda O Veri, James D R Knight, Dushyandi Rajendran, Amber L Couzens, Ko W Currie, Johnny M Tkach, Sally W T Cheung, Laurence Pelletier, Anne-Claude Gingras
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence interactions (1,104 previously unreported), implicating these phosphatases in the regulation of a variety of cellular processes...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27806013/the-effect-of-high-speed-strength-training-on-physical-performance-in-young-soccer-players-of-different-ages
#13
David Rodriguez-Rosell, Felipe Franco-Márquez, Ricardo Mora-Custodio, Juan José González-Badillo
The aim of the present study was to compare the effectiveness of low-load, low-volume weight training combined with plyometrics on strength, sprint and jump performance in soccer players of different ages. Eighty-six soccer players from the same academy were categorized into 3 groups by age (under 13 year, U13, n = 30; under 15, U15, n = 28; under 17, U17, n = 28) and then randomly assigned into two subgroups: a strength training group (STG) and a control group (CG). The strength training program was performed twice a week for 6 weeks and consisted of full squats (load: 45-60% 1RM; volume: 3 set of 8-4 repetitions), jumps and straight line sprint exercises...
October 28, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27618386/effects-of-velocity-loss-during-resistance-training-on-performance-in-professional-soccer-players
#14
Fernando Pareja-Blanco, Luis Sánchez-Medina, Luis Suárez-Arrones, Juan José González-Badillo
PURPOSE: To analyze the effects of 2 resistance-training (RT) programs that used the same relative loading but different repetition volume, using the velocity loss during the set as the independent variable: 15% (VL15) vs 30% (VL30). METHODS: Sixteen professional soccer players with RT experience (age 23.8 ± 3.5 y, body mass 75.5 ± 8.6 kg) were randomly assigned to 2 groups, VL15 (n = 8) or VL30 (n = 8), that followed a 6-wk (18-session) velocity-based squat-training program...
April 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27489855/role-of-cysteine-residues-in-the-carboxyl-terminus-of-the-follicle-stimulating-hormone-receptor-in-intracellular-traffic-and-postendocytic-processing
#15
Brenda Melo-Nava, Patricia Casas-González, Marco A Pérez-Solís, Jean Castillo-Badillo, José L Maravillas-Montero, Eduardo Jardón-Valadez, Teresa Zariñán, Arturo Aguilar-Rojas, Nathalie Gallay, Eric Reiter, Alfredo Ulloa-Aguirre
Posttranslational modifications occurring during the biosynthesis of G protein-coupled receptors include glycosylation and palmitoylation at conserved cysteine residues located in the carboxyl-terminus of the receptor. In a number of these receptors, these modifications play an important role in receptor function and particularly, in intracellular trafficking. In the present study, the three cysteine residues present in the carboxyl-terminus of the human FSHR were replaced with glycine by site-directed mutagenesis...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27414074/light-load-maximal-lifting-velocity-full-squat-training-program-improves-important-physical-and-skill-characteristics-in-futsal-players
#16
Julio Torres-Torrelo, David Rodríguez-Rosell, Juan José González-Badillo
This study aimed to compare the effect of 6 weeks of resistance training or combined resistance training and change of direction exercises on physical performance and motor skills in futsal players. Thirty-four futsal players were divided into full squat group (SG, n = 12), combined full squat and change of direction exercises group (S+CDG, n = 12) and control group (CG, n = 10). The resistance training for SG consisted of full squat with low load (~45-58% 1RM) and low volume (4-6 repetitions), whereas the S+CDG performed the same resistance training program combined with loaded change of direction...
May 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27286181/mechanical-metabolic-and-perceptual-response-during-sprint-training
#17
P Jimenez-Reyes, F Pareja-Blanco, V Cuadrado-Peñafiel, J A Morcillo, J A Párraga, J J González-Badillo
This study aimed to analyze perceptual, metabolic and mechanical responses to sprint training sessions. 9 male high-level sprinters performed 40 m running sprints up to a loss of 3% in speed, with 4 min rests between sets. Perceptual (rating of perceived exertion, RPE), mechanical (speed and countermovement jump height loss) and metabolic (blood lactate and ammonia) parameters were measured pre-exercise and after each sprint was performed. Relationships between the variables were calculated with a 90% confidence interval...
September 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/27172267/traditional-vs-sport-specific-vertical-jump-tests-reliability-validity-and-relationship-with-the-legs-strength-and-sprint-performance-in-adult-and-teen-soccer-and-basketball-players
#18
David Rodríguez-Rosell, Ricardo Mora-Custodio, Felipe Franco-Márquez, Juan M Yáñez-García, Juan J González-Badillo
Rodríguez-Rosell, D, Mora-Custodio, R, Franco-Márquez, F, Yáñez-García, JM, González-Badillo, JJ. Traditional vs. sport-specific vertical jump tests: reliability, validity, and relationship with the legs strength and sprint performance in adult and teen soccer and basketball players. J Strength Cond Res 31(1): 196-206, 2017-The vertical jump is considered an essential motor skill in many team sports. Many protocols have been used to assess vertical jump ability. However, controversy regarding test selection still exists based on the reliability and specificity of the tests...
January 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27149669/interaction-between-hormonal-receptor-status-age-and-survival-in-patients-with-brca1-2-germline-mutations-a-systematic-review-and-meta-regression
#19
REVIEW
Arnoud J Templeton, Laura Diez Gonzalez, Francisco E Vera-Badillo, Ariadna Tibau, Robyn Goldstein, Boštjan Šeruga, Amirrtha Srikanthan, Atanasio Pandiella, Eitan Amir, Alberto Ocana
BACKGROUND: Germline mutations in the BRCA1 and BRCA2 genes are the most frequent known hereditary causes of familial breast cancer. Little is known about the interaction of age at diagnosis, estrogen receptor (ER) and progesterone receptor (PgR) expression and outcomes in patients with BRCA1 or BRCA2 mutations. METHODS: A PubMed search identified publications exploring the association between BRCA mutations and clinical outcome. Hazard ratios (HR) for overall survival were extracted from multivariable analyses...
2016: PloS One
https://www.readbyqxmd.com/read/27038416/effects-of-velocity-loss-during-resistance-training-on-athletic-performance-strength-gains-and-muscle-adaptations
#20
F Pareja-Blanco, D Rodríguez-Rosell, L Sánchez-Medina, J Sanchis-Moysi, C Dorado, R Mora-Custodio, J M Yáñez-García, D Morales-Alamo, I Pérez-Suárez, J A L Calbet, J J González-Badillo
We compared the effects of two resistance training (RT) programs only differing in the repetition velocity loss allowed in each set: 20% (VL20) vs 40% (VL40) on muscle structural and functional adaptations. Twenty-two young males were randomly assigned to a VL20 (n = 12) or VL40 (n = 10) group. Subjects followed an 8-week velocity-based RT program using the squat exercise while monitoring repetition velocity. Pre- and post-training assessments included: magnetic resonance imaging, vastus lateralis biopsies for muscle cross-sectional area (CSA) and fiber type analyses, one-repetition maximum strength and full load-velocity squat profile, countermovement jump (CMJ), and 20-m sprint running...
July 2017: Scandinavian Journal of Medicine & Science in Sports
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