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https://www.readbyqxmd.com/read/27880917/phenotypic-and-interaction-profiling-of-the-human-phosphatases-identifies-diverse-mitotic-regulators
#1
Nicole St-Denis, Gagan D Gupta, Zhen Yuan Lin, Beatriz Gonzalez-Badillo, Amanda O Veri, James D R Knight, Dushyandi Rajendran, Amber L Couzens, Ko W Currie, Johnny M Tkach, Sally W T Cheung, Laurence Pelletier, Anne-Claude Gingras
Reversible phosphorylation is a fundamental regulatory mechanism, intricately coordinated by kinases and phosphatases, two classes of enzymes widely disrupted in human disease. To better understand the functions of the relatively understudied phosphatases, we have used complementary affinity purification and proximity-based interaction proteomics approaches to generate a physical interactome for 140 human proteins harboring phosphatase catalytic domains. We identified 1,335 high-confidence interactions (1,104 previously unreported), implicating these phosphatases in the regulation of a variety of cellular processes...
November 22, 2016: Cell Reports
https://www.readbyqxmd.com/read/27806013/the-effect-of-high-speed-strength-training-on-physical-performance-in-young-soccer-players-of-different-ages
#2
David Rodriguez-Rosell, Felipe Franco-Márquez, Ricardo Mora-Custodio, Juan José González-Badillo
The aim of the present study was to compare the effectiveness of low-load, low-volume weight training combined with plyometrics on strength, sprint and jump performance in soccer players of different ages. Eighty-six soccer players from the same academy were categorized into 3 groups by age (under 13 year, U13, n = 30; under 15, U15, n = 28; under 17, U17, n = 28) and then randomly assigned into two subgroups: a strength training group (STG) and a control group (CG). The strength training program was performed twice a week for 6 weeks and consisted of full squats (load: 45-60% 1RM; volume: 3 set of 8-4 repetitions), jumps and straight line sprint exercises...
October 28, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27618386/effects-of-velocity-loss-during-resistance-training-on-performance-in-professional-soccer-players
#3
Fernando Pareja-Blanco, Luis Sánchez-Medina, Luis Suárez-Arrones, Juan José González-Badillo
AIM: To analyze the effects of two resistance training (RT) programs that used the same relative loading but different repetition volume, using the velocity loss during the set as the independent variable: 15% (VL15) vs. 30% (VL30). METHODS: Sixteen professional soccer players with RT experience (age 23.8 ± 3.5 years, body mass 75.5 ± 8.6 kg) were randomly assigned to two groups: VL15 (n = 8) or VL30 (n = 8) that followed a 6-week (18 sessions) velocity-based squat training program...
September 6, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/27489855/role-of-cysteine-residues-in-the-carboxyl-terminus-of-the-follicle-stimulating-hormone-receptor-in-intracellular-traffic-and-postendocytic-processing
#4
Brenda Melo-Nava, Patricia Casas-González, Marco A Pérez-Solís, Jean Castillo-Badillo, José L Maravillas-Montero, Eduardo Jardón-Valadez, Teresa Zariñán, Arturo Aguilar-Rojas, Nathalie Gallay, Eric Reiter, Alfredo Ulloa-Aguirre
Posttranslational modifications occurring during the biosynthesis of G protein-coupled receptors include glycosylation and palmitoylation at conserved cysteine residues located in the carboxyl-terminus of the receptor. In a number of these receptors, these modifications play an important role in receptor function and particularly, in intracellular trafficking. In the present study, the three cysteine residues present in the carboxyl-terminus of the human FSHR were replaced with glycine by site-directed mutagenesis...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27414074/light-load-maximal-lifting-velocity-full-squat-training-program-improves-important-physical-and-skill-characteristics-in-futsal-players
#5
Julio Torres-Torrelo, David Rodríguez-Rosell, Juan José González-Badillo
This study aimed to compare the effect of 6 weeks of resistance training or combined resistance training and change of direction exercises on physical performance and motor skills in futsal players. Thirty-four futsal players were divided into full squat group (SG, n = 12), combined full squat and change of direction exercises group (S+CDG, n = 12) and control group (CG, n = 10). The resistance training for SG consisted of full squat with low load (~45-58% 1RM) and low volume (4-6 repetitions), whereas the S+CDG performed the same resistance training program combined with loaded change of direction...
July 14, 2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/27286181/mechanical-metabolic-and-perceptual-response-during-sprint-training
#6
P Jimenez-Reyes, F Pareja-Blanco, V Cuadrado-Peñafiel, J A Morcillo, J A Párraga, J J González-Badillo
This study aimed to analyze perceptual, metabolic and mechanical responses to sprint training sessions. 9 male high-level sprinters performed 40 m running sprints up to a loss of 3% in speed, with 4 min rests between sets. Perceptual (rating of perceived exertion, RPE), mechanical (speed and countermovement jump height loss) and metabolic (blood lactate and ammonia) parameters were measured pre-exercise and after each sprint was performed. Relationships between the variables were calculated with a 90% confidence interval...
September 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/27172267/traditional-vs-sport-specific-vertical-jump-tests-reliability-validity-and-relationship-with-the-legs-strength-and-sprint-performance-in-adult-and-teen-soccer-and-basketball-players
#7
David Rodriguez-Rosell, Ricardo Mora-Custodio, Felipe Franco-Márquez, Juan Manuel Yáñez-García, Juan José González-Badillo
The vertical jump is considered an essential motor skill in many team sports. Many protocols have been used to assess vertical jump ability. However, controversy regarding test selection still exists based upon the reliability and specificity of the tests. The main aim of this study was to analyze the reliability and validity of two standardized [Countermovement jump (CMJ) and Abalakov jump (AJ)] and two sport-specific [run-up with two (2-LEGS) or one leg (1-LEG) take-off jump] vertical jump tests, and their usefulness as predictors of sprint and strength performance for soccer (n = 127) and basketball (n = 59) players in three different categories (Under-15, Under-18 and Adults)...
May 9, 2016: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/27149669/interaction-between-hormonal-receptor-status-age-and-survival-in-patients-with-brca1-2-germline-mutations-a-systematic-review-and-meta-regression
#8
Arnoud J Templeton, Laura Diez Gonzalez, Francisco E Vera-Badillo, Ariadna Tibau, Robyn Goldstein, Boštjan Šeruga, Amirrtha Srikanthan, Atanasio Pandiella, Eitan Amir, Alberto Ocana
BACKGROUND: Germline mutations in the BRCA1 and BRCA2 genes are the most frequent known hereditary causes of familial breast cancer. Little is known about the interaction of age at diagnosis, estrogen receptor (ER) and progesterone receptor (PgR) expression and outcomes in patients with BRCA1 or BRCA2 mutations. METHODS: A PubMed search identified publications exploring the association between BRCA mutations and clinical outcome. Hazard ratios (HR) for overall survival were extracted from multivariable analyses...
2016: PloS One
https://www.readbyqxmd.com/read/27038416/effects-of-velocity-loss-during-resistance-training-on-athletic-performance-strength-gains-and-muscle-adaptations
#9
F Pareja-Blanco, D Rodríguez-Rosell, L Sánchez-Medina, J Sanchis-Moysi, C Dorado, R Mora-Custodio, J M Yáñez-García, D Morales-Alamo, I Pérez-Suárez, J A L Calbet, J J González-Badillo
We compared the effects of two resistance training (RT) programs only differing in the repetition velocity loss allowed in each set: 20% (VL20) vs 40% (VL40) on muscle structural and functional adaptations. Twenty-two young males were randomly assigned to a VL20 (n = 12) or VL40 (n = 10) group. Subjects followed an 8-week velocity-based RT program using the squat exercise while monitoring repetition velocity. Pre- and post-training assessments included: magnetic resonance imaging, vastus lateralis biopsies for muscle cross-sectional area (CSA) and fiber type analyses, one-repetition maximum strength and full load-velocity squat profile, countermovement jump (CMJ), and 20-m sprint running...
March 31, 2016: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/27002490/validity-of-a-simple-method-for-measuring-force-velocity-power-profile-in-countermovement-jump
#10
Pedro Jiménez-Reyes, Pierre Samozino, Fernando Pareja-Blanco, Filipe Conceição, Víctor Cuadrado-Peñafiel, Juan José González-Badillo, Jean-Benoît Morin
PURPOSE: 1) to analyze the reliability and validity of a simple computation method to evaluate force (F), velocity (v) and power (P) output during a countermovement jump (CMJ) suitable for use in field conditions; and 2) to verify the validity of this computation method to compute the CMJ Force-velocity (F-v) profile (including unloaded and loaded jumps) in trained athletes. METHODS: Sixteen high-level male sprinters and jumpers performed maximal CMJs under six different load conditions (from 0 to 87 kg)...
March 22, 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/26990723/effect-of-low-vs-moderate-load-squat-training-on-strength-jump-and-sprint-performance-in-physically-active-women
#11
R Mora-Custodio, D Rodríguez-Rosell, F Pareja-Blanco, J M Yañez-García, J J González-Badillo
This study aimed to analyze the effects of resistance training (RT) load on neuromuscular performance. Twenty-seven physically active women were randomly distributed into 3 groups: a low-load group (LLG); a moderate-load group (MLG); and a control group (CG). The RT consisted of full squat exercise with a low load (40-60% 1RM, LLG) or a moderate load (65-80% 1RM, MLG). Sprint times (T10, T20, and T10-20), countermovement jump (CMJ), estimated one-repetition maximum (1RMest) and velocity attained against the first (FMPV) and the last load (LMPV) common to both tests were assessed pre- and post-test...
June 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/26970332/acute-and-delayed-response-to-resistance-exercise-leading-or-not-leading-to-muscle-failure
#12
Fernando Pareja-Blanco, David Rodríguez-Rosell, Luis Sánchez-Medina, Juan Ribas-Serna, Covadonga López-López, Ricardo Mora-Custodio, Juan Manuel Yáñez-García, Juan José González-Badillo
This study compared the time course of recovery following two resistance exercise protocols differing in the number of repetitions per set with regard to the maximum possible (to failure) number. Ten men performed three sets of 6 versus 12 repetitions with their 70% 1RM (3 × 6 [12] versus 3 × 12 [12]) in the bench press (BP) and squat (SQ) exercises. Mechanical [CMJ height, velocity against the 1 m s(-1) load (V1 -load)], biochemical [testosterone, cortisol, growth hormone, prolactin, insulin-like growth factor-1, creatine kinase (CK)] and heart rate variability (HRV) and complexity (HRC) were assessed pre-, postexercise (Post) and at 6, 24 and 48 h-Post...
March 11, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/26667923/short-term-recovery-following-resistance-exercise-leading-or-not-to-failure
#13
J J González-Badillo, D Rodríguez-Rosell, L Sánchez-Medina, J Ribas, C López-López, R Mora-Custodio, J M Yañez-García, F Pareja-Blanco
This study analyzed the time course of recovery following 2 resistance exercise protocols differing in level of effort: maximum (to failure) vs. half-maximum number of repetitions per set. 9 males performed 3 sets of 4 vs. 8 repetitions with their 80% 1RM load, 3×4(8) vs. 3×8(8), in the bench press and squat. Several time-points from 24 h pre- to 48 h post-exercise were established to assess the mechanical (countermovement jump height, CMJ; velocity against the 1 m·s(-1) load, V1-load), biochemical (testosterone, cortisol, GH, prolactin, IGF-1, CK) and heart rate variability (HRV) and complexity (HRC) response to exercise...
April 2016: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/26604269/circulating-dna-and-survival-in-solid-tumors
#14
Alberto Ocaña, Laura Díez-González, Dolores C García-Olmo, Arnoud J Templeton, Francisco Vera-Badillo, María José Escribano, Gemma Serrano-Heras, Verónica Corrales-Sánchez, Bostjan Seruga, Fernando Andrés-Pretel, Atanasio Pandiella, Eitan Amir
BACKGROUND: The ability to undertake molecular analysis to inform on prognosis and predictors of response to therapy is limited by accessibility of tissue. Measurement of total circulating free DNA (cfDNA) or circulating tumor DNA (ctDNA) in peripheral blood may allow easier access to tumor material and help to predict clinical outcomes. METHODS: A systematic review of electronic databases identified publications exploring the association between cfDNA or ctDNA and overall survival (OS) in solid tumors...
February 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/26537985/jump-squat-performance-and-its-relationship-with-relative-training-intensity-in-high-level-athletes
#15
Pedro Jiménez-Reyes, Fernando Pareja-Blanco, Carlos Balsalobre-Fernández, Víctor Cuadrado-Peñafiel, Manuel A Ortega-Becerra, Juan J González-Badillo
PURPOSE: To examine the relationship between the relative load in full squats and the height achieved in jump-squat (JS) exercises and to determine the load that maximizes the power output of high-level athletes. METHOD: Fifty-one male high-level track-and-field athletes (age 25.2 ± 4.4 y, weight 77. ± 6.2 kg, height 179.9 ± 5.6 cm) who competed in sprinting and jumping events took part in the study. Full-squat 1-repetition-maximum (1-RM) and JS height (JH) with loads from 17 to 97 kg were measured in 2 sessions separated by 48 h...
November 2015: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/26446908/influence-of-companion-diagnostics-on-efficacy-and-safety-of-targeted-anti-cancer-drugs-systematic-review-and-meta-analyses
#16
REVIEW
Alberto Ocana, Josee-Lyne Ethier, Laura Díez-González, Verónica Corrales-Sánchez, Amirrtha Srikanthan, María J Gascón-Escribano, Arnoud J Templeton, Francisco Vera-Badillo, Bostjan Seruga, Saroj Niraula, Atanasio Pandiella, Eitan Amir
BACKGROUND: Companion diagnostics aim to identify patients that will respond to targeted therapies, therefore increasing the clinical efficacy of such drugs. Less is known about their influence on safety and tolerability of targeted anti-cancer agents. METHODS AND FINDINGS: Randomized trials evaluating targeted agents for solid tumors approved by the US Food and Drug Administration since year 2000 were assessed. Odds ratios (OR) and and 95% confidence intervals (CI) were computed for treatment-related death, treatment-discontinuation related to toxicity and occurrence of any grade 3/4 adverse events (AEs)...
November 24, 2015: Oncotarget
https://www.readbyqxmd.com/read/26444293/determining-the-optimum-power-load-in-jump-squat-using-the-mean-propulsive-velocity
#17
Irineu Loturco, Fabio Yuzo Nakamura, Valmor Tricoli, Ronaldo Kobal, Cesar Cavinato Cal Abad, Katia Kitamura, Carlos Ugrinowitsch, Saulo Gil, Lucas Adriano Pereira, Juan José González-Badillo
The jump squat is one of the exercises most frequently used to improve lower body power production, which influences sports performance. However, the traditional determination of the specific workload at which power production is maximized (i.e., optimum power load) is time-consuming and requires one-repetition maximum tests. Therefore, the aim of this study was to verify whether elite athletes from different sports would produce maximum mean propulsive power values at a narrow range of mean propulsive velocities, resulting in similar jump heights...
2015: PloS One
https://www.readbyqxmd.com/read/26395837/movement-velocity-as-a-measure-of-exercise-intensity-in-three-lower-limb-exercises
#18
Filipe Conceição, Juvenal Fernandes, Martin Lewis, Juan José Gonzaléz-Badillo, Pedro Jimenéz-Reyes
The purpose of this study was to investigate the relationship between movement velocity and relative load in three lower limbs exercises commonly used to develop strength: leg press, full squat and half squat. The percentage of one repetition maximum (%1RM) has typically been used as the main parameter to control resistance training; however, more recent research has proposed movement velocity as an alternative. Fifteen participants performed a load progression with a range of loads until they reached their 1RM...
2016: Journal of Sports Sciences
https://www.readbyqxmd.com/read/26218231/effects-of-6-weeks-resistance-training-combined-with-plyometric-and-speed-exercises-on-physical-performance-of-pre-peak-height-velocity-soccer-players
#19
David Rodriguez-Rosell, Felipe Franco-Márquez, Fernando Pareja-Blanco, Ricardo Mora-Custodio, Juan M Yáñez-García, José M González-Suárez, Juan J González-Badillo
PURPOSE: To analyze the effects of low-load, high-velocity resistance training (RT) combined with plyometrics on physical performance in pre-peak-height-velocity (PHV) soccer players. METHODS: Thirty young soccer players from the same academy were randomly assigned to either a strength training (STG, n = 15) or a control group (CG, n = 15). Strength training consisted of full squat exercise with low load (45-58% 1RM) and low volume (4-8 repetitions/set) combined with jumps and sprints twice a week over 6 wk of preseason...
March 2016: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/26182442/maximal-velocity-as-a-discriminating-factor-in-the-performance-of-loaded-squat-jumps
#20
Pedro Jiménez-Reyes, Fernando Pareja-Blanco, David Rodríguez-Rosell, Mario C Marques, Juan José González-Badillo
PURPOSE: To determine what variables determine the differences in performance on 2 tests of squat jump (SJ) performed under light load in highly trained athletes using maximal velocity (Vmax) or flight time (FT) as the discriminating factor of SJ performance. METHODS: Thirty-two participants performed 2 maximal weighted SJs using a force platform synchronized with a linear transducer. Mean force (Fmean), mean and maximal power (Pmean, Pmax), peak force (PF), maximal rate of force development (RFDmax), and time required to attain PF (TPF) and RFDmax (TRFDmax) were analyzed...
March 2016: International Journal of Sports Physiology and Performance
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