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https://www.readbyqxmd.com/read/28546527/effect-of-necrosis-on-the-mirna-mrna-regulatory-network-in-crt-mg-human-astroglioma-cells
#1
So-Hee Ahn, Jung-Hyuck Ahn, Dong-Ryeol Ryu, Jisoo Lee, Min-Sun Cho, Youn-Hee Choi
Purpose: Glioblastoma multiforme (GBM) is the most common adult primary intracranial tumor. The remarkable features of GBM include central necrosis. MicroRNAs (miRNAs) have been considered as diagnostic/prognostic biomarkers for many cancers, including glioblastoma. However, the effect of necrosis on the miRNA expression profile and predicted miRNA-mRNA regulatory information remain unclear. The purpose of this study is to examine the effect of necrotic cells on the modulation of miRNA and mRNA expression profiles and miRNA-mRNA network in CRT-MG cells...
May 22, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28546098/altered-long-non-coding-rna-expression-profile-in-rabbit-atria-with-atrial-fibrillation-tcons_00075467-modulates-atrial-electrical-remodeling-by-sponging-mir-328-to-regulate-cacna1c
#2
Zhan Li, Ximin Wang, Weizong Wang, Juanjuan Du, Jinqiu Wei, Yong Zhang, Jiangrong Wang, Yinglong Hou
Electrical remodeling has been reported to play a major role in the initiation and maintenance of atrial fibrillation (AF). Long non-coding RNAs (lncRNAs) have been increasingly recognized as contributors to the pathology of heart diseases. However, the roles and mechanisms of lncRNAs in electrical remodeling during AF remain unknown. In this study, the lncRNA expression profiles of right atria were investigated in AF and non-AF rabbit models by using RNA sequencing technique and validated using quantitative real-time polymerase chain reaction (qRT-PCR)...
May 22, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28546024/mirna-8159-is-involved-in-tlr-signaling-pathway-regulation-after-pathogen-infection-by-direct-targeting-tlr13-in-miiuy-croaker
#3
Junxia Cui, Yunhang Gao, Qing Chu, Dekun Bi, Tianjun Xu
Toll-like receptors (TLRs) play a crucial role in the recognition of immune reactions against invading pathogens. The molecular regulation mechanisms of TLR expression in aquatic organisms remain unclear. MicroRNAs (miRNAs) are small non-coding RNAs that are critical adjustors of immune signaling pathway at the post-transcriptional level and play critical roles in intricate networks of host-pathogen interactions and innate immunity. The critical role of TLRs in host defense for discerning certain kinds of pathogen associated molecular patternsand striking a cascade immune response in fish have been demonstrated...
May 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28545608/differential-regulation-analysis-reveals-dysfunctional-regulatory-mechanism-involving-transcription-factors-and-micrornas-in-gastric-carcinogenesis
#4
Quanxue Li, Junyi Li, Wentao Dai, Yi-Xue Li, Yuan-Yuan Li
Gastric cancer (GC) is one of the most incident malignancies in the world. Although lots of featured genes and microRNAs (miRNAs) have been identified to be associated with gastric carcinogenesis, underlying regulatory mechanisms still remain unclear. In order to explore the dysfunctional mechanisms of GC, we developed a novel approach to identify carcinogenesis relevant regulatory relationships, which is characterized by quantifying the difference of regulatory relationships between stages. Firstly, we applied the strategy of differential coexpression analysis (DCEA) to transcriptomic datasets including paired mRNA and miRNA of gastric samples to identify a set of genes/miRNAs related to gastric cancer progression...
March 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28545454/combining-serum-mirnas-cea-and-cyfra21-1-with-imaging-and-clinical-features-to-distinguish-benign-and-malignant-pulmonary-nodules-a-pilot-study-xianfeng-li-et-al-combining-biomarker-imaging-and-clinical-features-to-distinguish-pulmonary-nodules
#5
Xianfeng Li, Qinghua Zhang, Xiayun Jin, Lihua Cao
BACKGROUND: Our study was designed to improve the accuracy of determining whether pulmonary nodules are benign or malignant. METHODS: We evaluated the clinical and imaging features and serum markers: neuron specific enolase (NSE), carcino-embryonic antigen (CEA), cytokeratin fragment antigen 21-1 (CYFRA 21-1), miRNA-21-5p, and miR-574-5pof in 39 patients with pathology information. Factors that differed significantly between those with benign versus malignant pulmonary nodules were used to establish a prediction model for identifying malignant nodules...
May 25, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28544907/micrornas-that-affect-the-fanconi-anemia-brca-pathway-are-downregulated-in-imatinib-resistant-chronic-myeloid-leukemia-patients-without-detectable-bcr-abl-kinase-domain-mutations
#6
E Yap, Z A Norziha, A Simbun, N R Tumian, S K Cheong, C F Leong, C L Wong
Chronic myeloid leukemia (CML) patients who do not achieve landmark responses following treatment with imatinib mesylate (IM) are considered IM-resistant. Although IM-resistance can be due to BCR-ABL kinase domain (KD) mutations, many IM-resistant patients do not have detectable BCR-ABL KD mutations. MicroRNAs (miRNAs) are short non-coding RNAs that control gene expression. To investigate the role of miRNAs in IM-resistance, we recruited 8 chronic phase CML patients with IM-resistance who tested negative for BCR-ABL KD mutations and 2 healthy normal controls...
May 18, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28543764/mir-31-regulates-spermatogonial-stem-cells-meiosis-via-targeting-stra8
#7
Yingjie Wang, Qisheng Zuo, Yulin Bi, Wenhui Zhang, Jin Jin, Liangliang Zhang, Ya-Ni Zhang, Bichun Li
Stra8 (stimulated by retinoic acid gene 8) is a specific gene that is expressed in mammalian germ cells during transition from mitosis to meiosis and plays a key role in the initiation of meiosis in mammals and birds. So, the evaluation of the Stra8 pathway in cSSCs may provide a deeper insight into mammalian spermatogenesis. miRNA was also an important regulating factor for meiosis of SSCs. However, there is currently no data indicating that miRNA regulate the meiosis of SSCs via Stra8. Here, we predicted the prospective miRNA targeting to Stra8 using the online Bioinformatics database-Targetscan, and performed an analysis of the dual-luciferase recombinant vector, pGL3-CMV-LUC-MCS-Stra8-3'UTR...
May 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28542273/expression-profile-of-epstein-barr-virus-and-human-adenovirus-small-rnas-in-tonsillar-b-and-t-lymphocytes
#8
Farzaneh Assadian, Wael Kamel, Göran Laurell, Catharina Svensson, Tanel Punga, Göran Akusjärvi
We have used high-throughput small RNA sequencing to characterize viral small RNA expression in purified tonsillar B and T lymphocytes isolated from patients tested positive for Epstein-Barr virus (EBV) or human adenovirus (HAdV) infections, respectively. In the small set of patients analyzed, the expression profile of EBV and HAdV miRNAs could not distinguish between patients diagnosed with tonsillar hypertrophy or chronic/recurrent tonsillitis. The EBV miR-BART expression profile among the patients diagnosed with tonsillar diseases resembles most closely the pattern seen in EBV+ tumors (Latency II/I)...
2017: PloS One
https://www.readbyqxmd.com/read/28542189/mir-277-4989-regulate-transcriptional-landscape-during-juvenile-to-adult-transition-in-the-parasitic-helminth-schistosoma-mansoni
#9
Anna V Protasio, Stijn van Dongen, Julie Collins, Leonor Quintais, Diogo M Ribeiro, Florian Sessler, Martin Hunt, Gabriel Rinaldi, James J Collins, Anton J Enright, Matthew Berriman
Schistosomes are parasitic helminths that cause schistosomiasis, a disease affecting circa 200 million people, primarily in underprivileged regions of the world. Schistosoma mansoni is the most experimentally tractable schistosome species due to its ease of propagation in the laboratory and the high quality of its genome assembly and annotation. Although there is growing interest in microRNAs (miRNAs) in trematodes, little is known about the role these molecules play in the context of developmental processes...
May 23, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28540688/machine-learning-techniques-in-exploring-microrna-gene-discovery-targets-and-functions
#10
Sumi Singh, Ryan G Benton, Anurag Singh, Anshuman Singh
In recent years, the role of miRNAs in post-transcriptional gene regulation has provided new insights into the understanding of several types of cancers and neurological disorders. Although miRNA research has gathered great momentum since its discovery, traditional biological methods for finding miRNA genes and targets continue to remain a huge challenge due to the laborious tasks and extensive time involved. Fortunately, advances in computational methods have yielded considerable improvements in miRNA studies...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28540682/the-limitations-of-existing-approaches-in-improving-microrna-target-prediction-accuracy
#11
Rasiah Loganantharaj, Thomas A Randall
MicroRNAs (miRNAs) are small (18-24 nt) endogenous RNAs found across diverse phyla involved in posttranscriptional regulation, primarily downregulation of mRNAs. Experimentally determining miRNA-mRNA interactions can be expensive and time-consuming, making the accurate computational prediction of miRNA targets a high priority. Since miRNA-mRNA base pairing in mammals is not perfectly complementary and only a fraction of the identified motifs are real binding sites, accurately predicting miRNA targets remains challenging...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28540680/computational-prediction-of-microrna-target-genes-target-prediction-databases-and-web-resources
#12
Justin T Roberts, Glen M Borchert
MicroRNA (miRNA) mediated silencing and repression of mRNA molecules requires complementary base pairing between the "seed" region of the miRNA and the "seed match" region of target mRNAs. While this mechanism is fairly well understood, accurate prediction of valid miRNA targets remains challenging due to factors such as imperfect sequence specificity, target site availability, and the thermodynamic stability of the mRNA structure itself. As knowledge of what genes are being targeted by each miRNA is arguably the most important facet of miRNA biology, many approaches have been developed to address the need for reliable prediction and ranking of putative targets, with most using a combination of various strategies such as evolutionary conservation, statistical inference, and distinct features of the target sequences themselves...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28540679/genome-wide-analysis-of-microrna-regulated-transcripts
#13
David Chevalier, Glen M Borchert
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by either degrading transcripts or repressing translation . Over the past decade the significance of miRNAs has been unraveled by the characterization of their involvement in crucial cellular functions and the development of disease. However, continued progress in understanding the endogenous importance of miRNAs, as well as their potential uses as therapeutic tools, has been hindered by the difficulty of positively identifying miRNA targets...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28539288/-predictive-value-of-mirna-29a-and-mirna-10a-5p-for-28-day-mortality-in-patients-with-sepsis-induced-acute-kidney-injury
#14
Rui Huo, Min Dai, Yi Fan, Jing-Zheng Zhou, Li Li, Jian Zu
OBJECTIVE: To investigate the value of miR-29a and miR-10a-5p in predicting 28-day mortality in patients with sepsis-induced acute kidney injury. METHODS: Seventy-four patients with sepsis-induced acute kidney injury (AKI) and 41 patients with sepsis but without AKI (control) were examined for serum levels of miR-29a and miR-10a-5p using RT-PCR. The patients were followed up for 28 days to record their survival. Pearson correlation analysis was used to test the correlations of miR-29a and miR-10a-5p with serum creatinine (Scr), cystatin C (Cys-C), and KIM-1 in patients with AKI...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28539268/mir-221-mediates-the-epithelial-mesenchymal-transition-of-hepatocellular-carcinoma-by-targeting-adipor1
#15
Tong Li, Min Li, Shaobo Hu, Xiang Cheng, Yang Gao, Shuai Jiang, Qihong Yu, Chen Zhang, Ping Sun, Wenjing Xian, Zifang Song, Yong Zhang, Qichang Zheng
Recent studies have shown that miRNAs play vital roles in tumorigenesis. However, their effects on the epithelial-mesenchymal transition (EMT) in hepatocellular carcinoma (HCC) need to be better understood. Our present study demonstrates that miR-221, which is overexpressed in HCC tissues, promotes EMT in HCC cell lines by targeting a new gene, AdipoR1. First, overexpression of miR-221 was identified in 40 pairs of human HCC tumor and matched normal tissues. Moreover, we found that elevated miR-221 was strongly associated with worse clinicopathologic features in HCC patients...
May 21, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28538367/identifying-mirna-mrna-regulation-network-of-chronic-pancreatitis-based-on-the-significant-functional-expression
#16
Dan Wang, Lei Xin, Jin-Huan Lin, Zhuan Liao, Jun-Tao Ji, Ting-Ting Du, Fei Jiang, Zhao-Shen Li, Liang-Hao Hu
BACKGROUND: The aim of this study was to explore the underlying molecular mechanism and potential molecular biomarkers of chronic pancreatitis (CP) and construct a miRNA-mRNA regulation network. METHODS: To explore the involvement of miRNAs in CP, we downloaded the miRNA and mRNA expression profiles of CP patients and healthy controls and identified the differentially expressed miRNAs and genes. Functional analysis was conducted and significant pathways were utilized...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28537673/comprehensive-analysis-of-microrna-mrna-signature-in-colon-adenocarcinoma
#17
J-Y Wang, C-L Wang, X-M Wang, F-J Liu
OBJECTIVE: The goal of our study was to identify the regulatory mechanisms of gene expression mediated by miRNAs and DNA methylation in colon adenocarcinoma (COAD). MATERIALS AND METHODS:   The miRNAs and mRNAs expression and DNA methylation data of COAD and adjacent normal tissues were obtained from The Cancer Genome Atlas (TCGA) database. Based on the differentially expressed miRNAs and mRNAs, miRNA-mRNA pairs were obtained by correlation analysis and prediction algorithms...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28537672/mir-425-5p-promotes-tumor-progression-via-modulation-of-cyld-in-gastric-cancer
#18
Y-F Yan, F-M Gong, B-S Wang, W Zheng
OBJECTIVE: MicroRNAs (miRNAs) have emerged as important gene regulators and are recognized as key players in carcinogenesis. The present study investigated the role of miR-425-5p in the development and progression of gastric cancer (GC). PATIENTS AND METHODS: The miR-425-5p level in GC tissues and cells was assayed by qRT-PCR. Then, the effects of miR-425-5p expression on the biological behavior of GC cells were investigated. Analysis of target protein expression was determined by Western blotting...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28537507/electroacupuncture-alleviated-brain-damages-through-mir-191a-5p-targeting-neuronal-calcium-sensor-1-after-ischemic-stroke
#19
Heng Zhou, Ceng Yang, Fuhai Bai, Zhi Ma, Jingyi Wang, Feng Wang, Feng Li, Qiang Wang, Lize Xiong
Electroacupuncture (EA) administration before or after cerebral ischemia has been shown to afford protection against ischemic injury. However, the underlying mechanism of EA-mediated protection is still unclear. Functional microRNAs (miRNAs) are believed to play important roles in neuroprotection and synaptic plasticity during and after ischemia. In a previous study, we identified 20 miRNAs that are expressed in the penumbra and are significantly changed after EA treatment. Here, we used bioinformatics analysis to predict the biological functions and gene-networks of these miRNAs...
May 24, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28537131/acupuncture-ameliorates-postoperative-ileus-via-il-6-mir-19a-kit-axis-to-protect-interstitial-cells-of-cajal
#20
Jingjing Deng, Shu Yang, Qing Yuan, Yuzhong Chen, Dandan Li, Haimei Sun, Xinghua Tan, Fuchun Zhang, Deshan Zhou
Acupuncture is a therapy effective in treating postoperative ileus (POI); its underlying mechanisms remain unclear. MicroRNAs (miRNAs) participate in inflammation and injury to the interstitial cells of Cajal (ICCs), both of which are considered to be contributors to POI. C-kit, encoding KIT, a specific marker of ICCs, is predicted to be targeted by miR-19a, an inflammation-related miRNA. Therefore, we investigated a possible link between inflammation, miR-19a, and ICCs in POI, as well as the mechanism by which these factors are affected by acupuncture...
May 24, 2017: American Journal of Chinese Medicine
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