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https://www.readbyqxmd.com/read/29221754/up-regulation-of-ypel1-and-ypel5-and-down-regulation-of-itga2-in-erlotinib-treated-egfr-mutant-non-small-cell-lung-cancer-a-bioinformatic-analysis
#1
Xiaoli Wu
PURPOSE: This study aimed to identify genes with significant alteration following treatment of epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) with tyrosine kinase inhibitors (TKIs). METHODS: We downloaded microarray data of GSE67051 from the Gene Expression Omnibus (GEO) database. Genes with differential expression were identified in two groups: erlotinib-treated versus DMSO-treated PC9 cells and erlotinib-treated versus DMSO-treated HCC827 cells...
December 5, 2017: Gene
https://www.readbyqxmd.com/read/29218111/the-diagnostic-value-of-microrna-4787-5p-and-microrna-4306-in-patients-with-acute-aortic-dissection
#2
Lei Wang, Shijie Zhang, Zhigao Xu, Jingjing Zhang, Li Li, Guoqiang Zhao
Acute aortic dissection (AAD) is a life-threatening cardiovascular disease with the high morbidity and mortality. Imaging modalities are the gold standard for the diagnosis of AAD; however, they are not always available in emergency department. Biomarker-assisted diagnosis is important for the early treatment of AAD. The aim of the present study was to identify potential microRNA (miRNA) biomarkers for AAD. Differentially expressed plasma miRNAs between AAD patients and age-matched healthy volunteers were analyzed by miRNA microarray...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218094/mir-351-negatively-regulates-osteoblast-differentiation-of-mscs-induced-by-cholesten-3-one-through-targeting-vdr
#3
Qiuke Hou, Yongquan Huang, Yiwen Luo, Bin Wang, Yamei Liu, Rudong Deng, Saixia Zhang, Fengbin Liu, Dongfeng Chen
Our previous reports indicated that (+)-cholesten-3-one induces osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs) by activating vitamin D receptor (VDR). However, whether and how miRNAs modulate osteogenic differentiation induced by (+)-cholesten-3-one have not been explored. In this study, miRNA array profiling and further validation by quantitative real-time PCR revealed that miR-351 was downregulated during (+)-cholesten-3-one-induced osteogenic differentiation of MSCs. Overexpression of miR-351 by miR-351 precursor transfection markedly inhibited the expression of osteoblast-specific genes, such as alkaline phosphatase (ALP), collagen type II, osteopontin (OPN), and runt-related transcription factor 2 (RUNX2), which consequently decreased a number of calcium mineralized nodules...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29218085/identification-and-differential-expression-of-micrornas-in-1-25-dihydroxyvitamin-d3-induced-osteogenic-differentiation-of-human-adipose-derived-mesenchymal-stem-cells
#4
Huijie Gu, Jun Xu, Zhongyue Huang, Liang Wu, Kaifeng Zhou, Yiming Zhang, Jiong Chen, Jiangni Xia, Xiaofan Yin
The aim of this study was to identify specific microRNAs (miRNAs) and their regulatory roles in the process of 1, 25-dihydroxyvitamin D3-induced (VD3-induced) osteogenic differentiation of human adipose-derived Mesenchymal stem cells (hAMSCs). The differentially expressed miRNAs in VD3-induced hAMSCs was examined. The putative target genes of these miRNAs were predicted. A total of 76 conserved miRNAs, including 18 miRNAs were significantly up-regulated and 58 miRNAs were significantly downregulated, and significantly differentially expressed between the two samples...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29217135/microrna-145-impedes-thrombus-formation-via-targeting-tissue-factor-in-venous-thrombosis
#5
Anita Sahu, Prabhash Kumar Jha, Amit Prabhakar, Heisnam Dinesh Singh, Neha Gupta, Tathagata Chatterjee, Tarun Tyagi, Swati Sharma, Babita Kumari, Somnath Singh, Velu Nair, Shailendra Goel, Mohammad Zahid Ashraf
Venous thromboembolism (VTE), the third leading cardiovascular complication, requires more understanding at molecular levels. Here, we have identified miR-145 as a key molecule for regulating thrombus formation in venous thrombosis (VT) employing network based bioinformatics approach and in vivo experiments. Levels of miR-145 showed an inverse correlation with thrombus load determined by coagulation variables. MiRNA target prediction tools and in vitro study identified tissue factor (TF) as a target gene for miR-145...
November 23, 2017: EBioMedicine
https://www.readbyqxmd.com/read/29216638/microrna-122-inhibits-lipid-droplet-formation-and-hepatic-triglyceride-accumulation-via-yin-yang-1
#6
Guo-Yi Wu, Chen Rui, Ji-Qiao Chen, Eiketsu Sho, Shan-Shan Zhan, Xian-Wen Yuan, Yi-Tao Ding
BACKGROUND/AIMS: An increase in intracellular lipid droplet formation and hepatic triglyceride (TG) content usually results in nonalcoholic fatty liver disease. However, the mechanisms underlying the regulation of hepatic TG homeostasis remain unclear. METHODS: Oil red O staining and TG measurement were performed to determine the lipid content. miRNA expression was evaluated by quantitative PCR. A luciferase assay was performed to validate the regulation of Yin Yang 1 (YY1) by microRNA (miR)-122...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29215815/plasma-microrna-21-26a-and-29a-3p-as-predictive-markers-for-treatment-response-following-transarterial-chemoembolization-in-patients-with-hepatocellular-carcinoma
#7
Soon Sun Kim, Hyo Jung Cho, Ji Sun Nam, Hyun Ji Kim, Dae Ryong Kang, Je Hwan Won, Jinoo Kim, Jai Keun Kim, Jei Hee Lee, Bo Hyun Kim, Mi Young Lee, Sung Won Cho, Jae Youn Cheong
BACKGROUND: We investigated an association between the levels of plasma microRNA (miRNA)-21, -26a, and -29a-3p and treatment outcomes following transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). METHODS: A total of 198 patients with TACE-treated HCC were followed up for TACE refractoriness and liver transplantation (LT)-free survival. Pretreatment plasma miRNA-21, -26a, and -29a-3p levels were measured using quantitative real-time polymerase chain reaction...
January 1, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29215200/mir-424-5p-reduces-ribosomal-rna-and-protein-synthesis-in-muscle-wasting
#8
Martin Connolly, Richard Paul, Roser Farre-Garros, Samantha A Natanek, Susannah Bloch, Jen Lee, Jose P Lorenzo, Harnish Patel, Cyrus Cooper, Avan A Sayer, Stephen J Wort, Mark Griffiths, Michael I Polkey, Paul R Kemp
BACKGROUND: A loss of muscle mass occurs as a consequence of a range of chronic and acute diseases as well as in older age. This wasting results from an imbalance of protein synthesis and degradation with a reduction in synthesis and resistance to anabolic stimulation often reported features. Ribosomes are required for protein synthesis, so changes in the control of ribosome synthesis are potential contributors to muscle wasting. MicroRNAs (miRNAs) are known regulators of muscle phenotype and have been shown to modulate components of the protein synthetic pathway...
December 7, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29214636/evolution-of-microrna827-targeting-in-the-plant-kingdom
#9
Wei-Yi Lin, Yen-Yu Lin, Su-Fen Chiang, Cueihuan Syu, Li-Ching Hsieh, Tzyy-Jen Chiou
Unlike most ancient microRNAs, which conservatively target homologous genes across species, microRNA827 (miR827) targets two different types of SPX (SYG1/PHO81/XPR1)-domain-containing genes, NITROGEN LIMITATION ADAPTATION (NLA) and PHOSPHATE TRANSPORTER 5 (PHT5), in Arabidopsis thaliana and Oryza sativa to regulate phosphate (Pi) transport and storage, respectively. However, how miR827 shifted its target preference and its evolutionary history are unknown. Based on target prediction analysis, we found that in most angiosperms, miR827 conservatively targets PHT5 homologs, but in Brassicaceae and Cleomaceae it preferentially targets NLA homologs, and we provide evidence for the transition of target preference during Brassicales evolution...
December 5, 2017: New Phytologist
https://www.readbyqxmd.com/read/29213288/microrna-214-suppresses-osteogenic-differentiation-of-human-periodontal-ligament-stem-cells-by-targeting-atf4
#10
Siqi Yao, Wei Zhao, Qianmin Ou, Lanchen Liang, Xuefeng Lin, Yan Wang
Periodontitis is the main cause of adult tooth loss. Stem cell-based tissue engineering has become a promising therapy for periodontitis treatment. To date, human periodontal ligament stem cells (hPDLSCs) have been shown to be a favorable source for tissue engineering, but modulatory mechanisms of hPDLSCs remain unclear. Approximately 60% of mammalian genes are the targets of over 2000 miRNAs in multiple human cell types, and miRNAs are able to influence various biological processes in the human body, including bone formation...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29212193/microrna-expression-profiling-in-exosomes-derived-from-gastric-cancer-stem-like-cells
#11
Zhan-Peng Sun, An-Qi Li, Wen-Huan Jia, Sen Ye, Grace Van Eps, Jian-Min Yu, Wei-Jun Yang
Cancer stem-like cells (CSCs) have been identified as the initial cell in formation of cancer. Quiescent CSCs can "hide out" from traditional cancer therapy which may produce an initial response but are often unsuccessful in curing patients. Thus, levels of CSC in patients may be used as an indicator to measure the chance of recurrence of cancer after therapy. The goals of our work are to develop specific exosomal miRNA clusters for gastric CSCs that can potentially predict which patients are at high risk for developing gastric cancer (GC) in order to diagnose GC at an early stage...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212155/small-molecule-mediated-induction-of-mir-9-suppressed-vascular-smooth-muscle-cell-proliferation-and-neointima-formation-after-balloon-injury
#12
Onju Ham, Se-Yeon Lee, Byeong-Wook Song, Chang Youn Lee, Jiyun Lee, Hyang-Hee Seo, Sang Woo Kim, Soyeon Lim, Il-Kwon Kim, Seahyoung Lee, Ki-Chul Hwang
Pathologic proliferation and migration of vascular smooth muscle cells (VSMCs) exacerbate cardiovascular disease. MicroRNAs (miRNAs), as endogenous inhibitors of protein synthesis, are expected to modulate pathologic proliferation of VSMCs. Here we report that both platelet-derived growth factor receptor (PDGFR) targeting miR-9 and a small molecule that increases miR-9 can inhibit the serum-induced proliferation of VSMCs. First, based on miRNA-target prediction databases and empirical data, we have selected miR-9 as a potent anti-proliferative miRNA in VSMCs...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29209617/mirroring-the-multiple-potentials-of-micrornas-in-acute-myocardial-infarction
#13
REVIEW
Solenne Paiva, Onnik Agbulut
At present, cardiovascular diseases are depicted to be the leading cause of death worldwide according to the World Health Organization. In the future, projections predict that ischemic heart disease will persist in the top main causes of illness. Within this alarming context, some tiny master regulators of gene expression programs, namely, microRNAs (miRNAs) carry three promising potentials. In fact, miRNAs can prove to be useful not only in terms of biomarkers allowing heart injury detection but also in terms of therapeutics to overcome limitations of past strategies and treat the lesions...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29209592/increased-expression-of-a-microrna-correlates-with-anthelmintic-resistance-in-parasitic-nematodes
#14
Victoria Gillan, Kirsty Maitland, Roz Laing, Henry Gu, Neil D Marks, Alan D Winter, David Bartley, Alison Morrison, Philip J Skuce, Andrew M Rezansoff, John S Gilleard, Axel Martinelli, Collette Britton, Eileen Devaney
Resistance to anthelmintic drugs is a major problem in the global fight against parasitic nematodes infecting humans and animals. While previous studies have identified mutations in drug target genes in resistant parasites, changes in the expression levels of both targets and transporters have also been reported. The mechanisms underlying these changes in gene expression are unresolved. Here, we take a novel approach to this problem by investigating the role of small regulatory RNAs in drug resistant strains of the important parasite Haemonchus contortus...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29209340/abiotic-stress-responsive-mirna-target-network-and-related-markers-snp-ssr-in-brassica-juncea
#15
Indra Singh, Shuchi Smita, Dwijesh C Mishra, Sanjeev Kumar, Binay K Singh, Anil Rai
Abiotic stress is one of the major factors responsible for huge yield loss in crop plants. MicroRNAs play a key role in adaptive responses of plants under abiotic stress conditions through post-transcriptional gene regulations. In present study, 95 potential miRNAs were predicted in Brassica juncea using comparative genomics approach. It was noted that these miRNAs, target several transcription factors (TFs), transporter family proteins, signaling related genes, and protease encoding genes. Nineteen distinct miRNA-target regulatory networks were observed with significant involvement in regulation of transcription, response to stimulus, hormone and auxin mediated signaling pathway related gene ontology (GO) term...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29209166/mir-145-5p-nurr1-tnf-%C3%AE-signaling-induced-microglia-activation-regulates-neuron-injury-of-acute-cerebral-ischemic-reperfusion-in-rats
#16
Xuemei Xie, Li Peng, Jin Zhu, Yang Zhou, Lingyu Li, Yanlin Chen, Shanshan Yu, Yong Zhao
Nurr1 is a member of the nuclear receptor 4 family of orphan nuclear receptors that is decreased in inflammatory responses and leads to neurons death in Parkinson's disease. Abnormal expression of Nurr1 have been attributed to various signaling pathways, but little is known about microRNAs (miRNAs) regulation of Nurr1 in ischemia/reperfusion injury. To investigate the post transcriptional regulatory networks of Nurr1, we used a miRNA screening approach and identified miR-145-5p as a putative regulator of Nurr1...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29209147/transcriptome-integration-analysis-in-hepatocellular-carcinoma-reveals-discordant-intronic-mirna-host-gene-pairs-in-expression
#17
Yulin Sun, Fubo Ji, Mia R Kumar, Xin Zheng, Yi Xiao, Niya Liu, Jiong Shi, Linda Wong, Marshonna Forgues, Lun-Xiu Qin, Zhao-You Tang, Xiaohang Zhao, Xin Wei Wang, Junfang Ji
Intronic miRNAs, residing in intronic regions of host genes, are thought to be co-transcribed from their host genes and present consistent expression patterns with host genes. Recent studies reported a few intronic miRNAs with discordant expression with their host genes. We therefore aimed to understand the expression pattern of intronic miRNAs and their host genes in hepatocellular carcinoma (HCC) and reveal possible associated molecular mechanisms. Our genome wide integration analysis of miRNA and mRNA transcriptomes, in three dataset from 550 patients with HCC, found that a large amount of miRNA-host gene pairs were discordantly expressed...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29209106/noncoding-rnas-as-drivers-of-the-phenotypic-plasticity-of-oesophageal-mucosa
#18
EDITORIAL
Matteo Fassan, Sonia Facchin, Giada Munari, Giuseppe Nicolò Fanelli, Greta Lorenzon, Edoardo Savarino
The histological commitment of the lower oesophageal mucosa largely depends on a complex molecular landscape. After extended inflammatory insult due to gastroesophageal reflux disease, squamous oesophageal mucosa may differentiate into columnar metaplastic mucosa. In this setting, the presence of intestinal metaplasia is considered the starting point of Barrett's carcinogenetic cascade. Aside from secondary prevention strategies for Barrett's mucosa (BM) patients, there are multiple endoscopic ablative therapies available for BM eradication and for the replacement of metaplastic epithelia with a neosquamous mucosa...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29208599/prognostic-mirna-classifier-in-early-stage-mycosis-fungoides-development-and-validation-in-a-danish-nationwide-study
#19
Lise M Lindahl, Søren Besenbacher, Anne H Rittig, Pamela Celis, Andreas Willerslev-Olsen, Lise M R Gjerdrum, Thorbjørn Krejsgaard, Claus Johansen, Thomas Litman, Anders Woetmann, Niels Odum, Lars Iversen
Mycosis fungoides (MF) is the most frequent form of cutaneous T-cell lymphoma. The disease often takes an indolent course, but in approximately one third of the patients, the disease progresses to an aggressive malignancy with a poor prognosis. At the time of diagnosis, it is impossible to predict which patients develop severe disease and are in need of aggressive treatment. Accordingly, we investigated the prognostic potential of microRNAs (miRNAs) at the time of diagnosis in MF. Using a qRT-PCR platform, we analysed miRNA expression in diagnostic skin biopsies from 154 Danish patients with early-stage MF...
December 5, 2017: Blood
https://www.readbyqxmd.com/read/29208566/mir-26a-and-mir-26b-mediate-osteoarthritis-progression-by-targeting-fut4-via-nf-%C3%AE%C2%BAb-signaling-pathway
#20
Jialei Hu, Zi Wang, Yue Pan, Jia Ma, Xiaoyan Miao, Xia Qi, Huimin Zhou, Li Jia
Osteoarthritis (OA) is the most common joint disease, characterized by articular cartilage degradation and changes in all other joint tissues. MicroRNAs (miRNAs) play an important role in mediating the main risk factors for OA. This study aimed to investigate the effect of miR-26a/26b on the proliferation and apoptosis of human chondrocytes by targeting fucosyltransferase 4 (FUT4) through NF-κB signaling pathway. We revealed the differential expression profiles of FUT4 and miR-26a/26b in the articular cartilage tissues of OA patients and normal people...
December 2, 2017: International Journal of Biochemistry & Cell Biology
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