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https://www.readbyqxmd.com/read/29471264/collective-transcriptomic-deregulation-of-hypertrophic-and-dilated-cardiomyopathy-importance-of-fibrotic-mechanism-in-heart-failure
#1
Beutline Malgija, Nachimuthu Senthil Kumar, Shanmughavel Piramanayagam
Myocardial fibrosis reside a common pathological feature in hypertrophic and dilated cardiomyopathy that results in ventricular dysfunction leading to heart failure. Though several studies reported the role of fibrosis in cardiac diseases, their pathologic mechanisms leading to heart failure remains unclear. A few studies have proposed integrated analysis of microarray information and protein-protein interaction (PPI) systems to discover subnetwork markers related to diagnosis and prognosis of the disease. In addition to PPI networks, we incorporated miRNAs and transcription factors to find the putative miRNAs and transcription factors that might regulate the pathological process and progression of cardiomyopathy and their further progression to heart failure...
February 10, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29470979/transcriptional-information-revealed-differentially-expressed-circular-rnas-in-facet-joint-osteoarthritis
#2
Chen Chu, Wu Chunshuai, Chen Jiajia, Zhang Jinlong, Xue Pengfei, Jiang Jiawei, Cui Zhiming
Circular RNAs are newly identified RNAs that regulate gene expression and execute various biological activities. Facet joint osteoarthritis (FJOA) is a severe facet joint cartilage degeneration disease that induces chronic low back pain to a larger population. The molecular mechanisms of FJOA, especially the presence and changes of circular RNAs in FJOA have not been investigated. In the current study, we analyzed RNA deep sequencing outcomes from healthy control group and FJOA group, identified and annotated circular RNAs, and determined the expressions of circular RNAs...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29469670/role-of-mirnas-in-treatment-response-and-toxicity-of-childhood-acute-lymphoblastic-leukemia
#3
Maitane Umerez, Susana Garcia-Obregon, Idoia Martin-Guerrero, Itziar Astigarraga, Angela Gutierrez-Camino, Africa Garcia-Orad
Childhood acute lymphoblastic leukemia survival rates have increased remarkably during last decades due, in part, to intensive treatment protocols. However, therapy resistance and toxicity are still two important barriers to survival. In this context, pharmacoepigenetics arises as a tool to identify new predictive markers, required to guide clinicians on risk stratification and dose individualization. The present study reviews current evidence about miRNA implication on childhood acute lymphoblastic leukemia therapy resistance and toxicity...
February 22, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29467872/differential-microrna-expression-profiles-in-tamoxifen-resistant-human-breast-cancer-cell-lines-induced-by-two-methods
#4
Peng Ye, Cheng Fang, Hui Zeng, Yu Shi, Zhongya Pan, Nairui An, Keli He, Li Zhang, Xinghua Long
Tamoxifen (TAM) resistance has become a severe problem for endocrine therapy of breast cancer. The present study investigated the association between microRNA (miRNA) expression and TAM resistance in breast cancer. The TAM-resistant breast cancer MCF-7C and MCF-7T cell lines were established using the human breast cancer cell line MCF-7 as the parental cell line and 4-hydroxytamoxifen (OHT) as the screening drug in vitro . The MCF-7C cell line was established by dose stepwise induction beginning with a low concentration of OHT; the MCF-7T cell line was established by temporal stepwise induction beginning with a high concentration of OHT...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29467665/analysis-of-microrna-expression-profiles-induced-by-yiqifumai-injection-in-rats-with-chronic-heart-failure
#5
Yu Zhao, Yunfei Li, Ling Tong, Xinying Liang, Han Zhang, Lan Li, Guanwei Fan, Yi Wang
Background: Yiqifumai Injection (YQFM) is clinically used to treat various cardiovascular diseases including chronic heart failure (CHF). The efficacy of YQFM for treating heart failure has been suggested, but the mechanism of action for pharmacological effects of YQFM is unclear. Methods: Echocardiography detection, left ventricular intubation evaluation, histopathology and immunohistochemical examination were performed in CHF rats to evaluate the cardioprotective effect of YQFM. Rat miRNA microarray and bioinformatics analysis were employed to investigate the differentially expressed microRNAs...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29466763/discovery-and-characterization-of-conserved-and-novel-micrornas-from-blunt-snout-bream-megalobrama-amblycephala-by-deep-sequencing
#6
Yong Huang, Wangbao Gong, Jianli Xiong, Xiao Chan Gao, Hong Tao Ren
MicroRNAs (miRNAs) are short, single stranded RNA molecules with approximately 22 nts in length, which regulate the stability and translation of messenger RNAs in several organisms. To increase the repertoire of miRNAs characterized in M. amblycephala, we used the deep sequencing technology to sequence a small RNA library using pooled RNA sample isolated from the 4 different tissues of M. amblycephala. A total of 309 conserved miRNAs that originated from 131 miRNA families were detected. 15 novel candidates miRNA were identified...
February 18, 2018: Gene
https://www.readbyqxmd.com/read/29464864/inferences-of-individual-drug-responses-across-diverse-cancer-types-using-a-novel-competing-endogenous-rna-network
#7
Yan Zhang, Xin Li, Dianshuang Zhou, Hui Zhi, Peng Wang, Yue Gao, Maoni Guo, Ming Yue, Yanxia Wang, Weitao Shen, Shangwei Ning, Yixue Li, Xia Li
Differences in individual drug responses is an obstacle to progression in cancer treatment, and predicting responses would help to plan treatment. The accumulation of cancer molecular profiling and drug response data provides opportunities and challenges to identify novel molecular signatures and mechanisms of tumor responsiveness to drugs. This study evaluated drug responses with a competing endogenous RNA (ceRNA) system that depended on competition between diverse RNA species. We identified drug response-related ceRNAs (DRCEs) by combining the sequence and expression data of long noncoding RNAs (lncRNAs), microRNAs (miRNAs) and messenger RNAs (mRNAs) and the survival data of cancer patients treated with drugs...
February 21, 2018: Molecular Oncology
https://www.readbyqxmd.com/read/29464486/microrna-322-cluster-promotes-tau-phosphorylation-via-targeting-brain-derived-neurotrophic-factor
#8
Jun Zhang, Zanchao Liu, Yuanyuan Pei, Wen Yang, Chicu Xie, Shiqi Long
Brain-derived neurotrophic factor (BDNF) is a crucial regulator to support synaptic plasticity and neuronal survival, its significant decrease is a pathophysiological hallmark in Alzheimer's disease (AD) brains and accounts for poor prognosis. MicroRNAs (miRNAs) interfere with the translation of target mRNAs and control a variety of physiological and pathological processes. MiR-322 is the rodent homologue of human miR-424, it is involved in the modulation of cell differentiation, proliferation, apoptosis and metabolic activities in diverse tissues and organs...
February 20, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29464088/deciphering-microrna-targets-in-pancreatic-cancer-using-mircomb-r-package
#9
Maria Vila-Casadesús, Elena Vila-Navarro, Giulia Raimondi, Cristina Fillat, Antoni Castells, Juan José Lozano, Meritxell Gironella
MiRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. They play important roles in cancer but little is known about the specific functions that each miRNA exerts in each type of cancer. More knowledge about their specific targets is needed to better understand the complexity of molecular networks taking part in cancer. In this study we report the miRNA-mRNA interactome occurring in pancreatic cancer by using a bioinformatic approach called miRComb, which combines tissue expression data with miRNA-target prediction databases (TargetScan, miRSVR and miRDB)...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29464019/the-involvement-of-serum-exosomal-mir-500-3p-and-mir-770-3p-in-aging-modulation-by-calorie-restriction
#10
Eun Kyeong Lee, Hyoung Oh Jeong, Eun Jin Bang, Chul Hong Kim, Ji Young Mun, Seulgi Noh, Jeong-An Gim, Dae Hyun Kim, Ki Wung Chung, Byung Pal Yu, Hae Young Chung
Recent studies have shown a role for miRNAs in aging and age-related diseases, and the modulation of miRNA expression by diet attracts attention as a new therapeutic strategy. Here, we focused on identifying specific exosomal miRNAs derived from serum of aged rats and the effect of short-term calorie restriction (CR) on their expression. Exosomes from serum of young (7-month), old (22-month), and old-CR Sprague Dawley rats were isolated and characterized by transmission electron microscopy analyses, dynamic light scattering measurements, and Western blotting...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29464002/mir-205-5p-and-mir-342-3p-cooperate-in-the-repression-of-the-e2f1-transcription-factor-in-the-context-of-anticancer-chemotherapy-resistance
#11
Xin Lai, Shailendra K Gupta, Ulf Schmitz, Stephan Marquardt, Susanne Knoll, Alf Spitschak, Olaf Wolkenhauer, Brigitte M Pützer, Julio Vera
High rates of lethal outcome in tumour metastasis are associated with the acquisition of invasiveness and chemoresistance. Several clinical studies indicate that E2F1 overexpression across high-grade tumours culminates in unfavourable prognosis and chemoresistance in patients. Thus, fine-tuning the expression of E2F1 could be a promising approach for treating patients showing chemoresistance. Methods: We integrated bioinformatics, structural and kinetic modelling, and experiments to study cooperative regulation of E2F1 by microRNA (miRNA) pairs in the context of anticancer chemotherapy resistance...
2018: Theranostics
https://www.readbyqxmd.com/read/29463374/nano-vesicles-are-a-potential-tool-to-monitor-therapeutic-efficacy-of-carbon-ion-radiotherapy-in-prostate-cancer
#12
Qi Yu, Ping Li, Meilin Weng, Shuang Wu, Yafang Zhang, Xue Chen, Qing Zhang, Guangxia Shen, Xianting Ding, Shen Fu
Exosomes are nano-vesicles that contribute to the effectiveness of many treatments. The aim of this study was to identify profiles of microRNA (miRNA) contained in serum exosomes that are differentially regulated in patients with prostate cancer undergoing carbon ion radiotherapy (CIRT). RNA was extracted from serum exosomes of eight patients with localized prostate cancer before and after CIRT, and miRNA was analyzed by the next generation sequencing. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the major signaling pathways associated with the proliferation of prostate cancer cells, such as MAPK, PI3K-AKT, mTOR, and AMPK may be implicated in the mechanism of CIRT action...
January 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29463215/association-of-differential-mirna-expression-with-hepatic-vs-peritoneal-metastatic-spread-in-colorectal-cancer
#13
Sabine Heublein, Markus Albertsmeier, David Pfeifer, Lisa Loehrs, Alexandr V Bazhin, Thomas Kirchner, Jens Werner, Jens Neumann, Martin Kurt Angele
BACKGROUND: Though peritoneal carcinomatosis reflects a late stage of colorectal cancer (CRC), only few patients present with synchronous or metachronous liver metastases alongside their peritoneal carcinomatosis. It is hypothesized that this phenomenon may be causally linked to molecular characteristics of the primary CRC. This study used miRNA profiling of primary CRC tissue either metastasized to the liver, to the peritoneum or not metastasized at all thus to identify miRNAs potentially associated with defining the site of metastatic spread in CRC...
February 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29461897/rna-protein-discordant-expression-of-fndc5-in-central-nervous-system-is-likely-to-be-mediated-through-micrornas
#14
Somayeh Tanhaei, Parvaneh Nikpour, Kamran Ghaedi, Farzaneh Rabiee, Farshad Homayouni Moghadam, Mohammad Hossein Nasr-Esfahani
Fibronectin type III domain-containing 5 protein (Fndc5) is responsible for producing a secretory protein termed, "irisin." A modified expression of Fndc5 has been reported in different tissues during development, differentiation processes, as well as in metabolic events such as exercise. One of the important issues to be fixed is whether Fndc5 RNA level and protein content are concerted and modified hand in hand. Therefore, the aim of this study is to assess Fndc5 RNA and protein levels in various tissues of mouse and rat with emphasis on brain...
February 20, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29461880/expression-profiles-of-six-atherosclerosis-associated-micrornas-that-cluster-in-patients-with-hyperhomocysteinemia-a-clinical-study
#15
Kejian Liu, Saiyare Xuekelati, Kang Zhou, Zhitao Yan, Xu Yang, Azeem Inayat, Jiangdong Wu, Xiaomei Guo
The aim of this study is to discuss the hypothesis that expression of plasma atherosclerosis-associated microRNAs (miRNAs) in hyperhomocysteinemia (Hhcy) patients could predict the presence of atherosclerosis from different channels. Six plasma miRNAs (miR-145, miR-155, miR-222, miR-133, miR-217, and miR-30) selected for our study have been confirmed as critical gene regulators involved in atherosclerosis and can be steadily determined in plasma. Expression of the above six plasma circulating miRNAs revealed significant upregulation of two miRNAs (miR-133 and miR-217) and downregulation of three miRNAs (miR-145, miR-155, and miR-222)...
February 20, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29459716/common-deregulation-of-seven-biological-processes-by-micrornas-in-gastrointestinal-cancers
#16
Lin Zhang, Yuchen Zhang, Sunny H Wong, Priscilla T Y Law, Shan Zhao, Jun Yu, Matthew T V Chan, William K K Wu
MicroRNAs are frequently dysregulated in human neoplasms, including gastrointestinal cancers. Nevertheless, the global influence of microRNA dysregulation on cellular signaling is still unknown. Here we sought to elucidate cellular signaling dysregulation by microRNAs in gastrointestinal cancers at the systems biology level followed by experimental validation. Signature dysregulated microRNAs in gastric, colorectal and liver cancers were defined based on our previous studies. Targets of signature dysregulated miRNAs were predicted using multiple computer algorithms followed by gene enrichment analysis to identify biological processes perturbed by dysregulated microRNAs...
February 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29456662/microrna-profiles-of-bmscs-induced-into-osteoblasts-with-osteoinductive-medium
#17
Zhixiong Yan, Yong Guo, Yang Wang, Yanan Li, Jiahui Wang
MicroRNA (miRNA) plays an important role in cell differentiation and functions as a regulator. Therefore, miRNA is important in the process of bone marrow mesenchymal stem cells (BMSCs) being induced into osteoblasts. In this study, mouse BMSCs were induced with osteoinductive medium, the indices related to osteoblastic differentiation were assayed, including alkaline phosphatase, the deposit of calcium and protein levels of osteocalcin. Using miRNA microarray and reverse transcription-quantitative polymerase chain reaction analyses, differentially expressed miRNAs in the cells, which were induced with osteoinductive medium, were selected and identified...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455649/molecular-subtyping-of-nasopharyngeal-carcinoma-npc-and-a-microrna-based-prognostic-model-for-distant-metastasis
#18
Lan Zhao, Alvin H W Fong, Na Liu, William C S Cho
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic cancer, with diverse molecular characteristics and clinical outcomes. This study aims to dissect the molecular heterogeneity of NPC, followed by the construction of a microRNA (miRNA)-based prognostic model for prediction of distant metastasis. METHODS: We retrieved two NPC datasets: GSE32960 and GSE70970 as training and validation cohorts, respectively. Consensus clustering was employed for cluster discovery, and support vector machine was used to build a classifier...
February 19, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29455432/serum-mirna-27a-and-mirna-18b-as-potential-predictive-biomarkers-of-hepatitis-c-virus-associated-hepatocellular-carcinoma
#19
Nearmeen M Rashad, Amal S El-Shal, Sally M Shalaby, Salem Y Mohamed
Hepatitis C virus (HCV) infection remains the main risk factor for chronic hepatitis (CHC), liver cirrhosis, and hepatocellular carcinoma (HCC). Changes in microRNA (miRNA) profiles can be associated with HCV infection and may either favor or inhibit the virus and/or its complication. Moreover, miRNAs have emerged as key regulators of various cancers including HCC. The aim of this work was to investigate the potentail role of miRNA-27a and miRNA-18b expression levels as non-invasive predictive biomarkers of hepatitis C virus-associated HCC...
February 17, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29455245/chronic-hyperinsulinemia-induced-mir-27b-is-linked-to-adipocyte-insulin-resistance-by-targeting-insulin-receptor
#20
Ankita Srivastava, Kripa Shankar, Muheeb Beg, Sujith Rajan, Abhishek Gupta, Salil Varshney, Durgesh Kumar, Sanchita Gupta, Raj Kumar Mishra, Anil Nilkanth Gaikwad
Defect in insulin signaling leads to the development of insulin resistance followed by type 2 diabetes. Exploiting our previously developed physiological chronic hyperinsulinemia (CI)-mediated insulin resistance (IR) model, we wanted to understand how miRNAs contribute to the development of IR. Amongst the identified and validate miRNAs, the expression of miR-27b was found to be highly upregulated during CI-induced IR in 3T3-L1 adipocytes. We also validated the expression of miR-27b in CI-induced IR in human mesenchymal stem cell (hMSC)-derived adipocytes and in vivo high fat diet (HFD)-induced IR mice model...
February 17, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
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