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Joud K Alsaeed, Aldana M Zayed, Zainab H Buhassan, Sara H Alhadrami, Yahya Naguib, Mariwan Husni
Depression occurring during pregnancy, often known as antenatal depression, is a significant mental illness with negative impacts on the mother's health, the health of the unborn baby, and the general welfare of the family. The condition is linked to various negative pregnancy outcomes, such as preterm birth, low birth weight, elevated risks of gestational diabetes, and preeclampsia. The signs and symptoms of depression in pregnancy do not differ from depression at any time. Another condition that may resemble symptoms of antenatal depression is hyperthyroidism, which is characterized by increased levels of thyroid hormones...
December 2023: Curēus
#22
EDITORIAL
Katherine C Awh, Sylvia Hsu
Pemphigoid gestationis (PG) is a rare autoimmune bullous disease that occurs during pregnancy or the postpartum period. PG has been associated with an increased risk of Graves' disease possibly due to shared genetic factors and immune system fluctuations during pregnancy. However, the evidence supporting the association between PG and Graves' disease is mixed. Although dermatologists are cautioned to watch for Graves' disease in patients with a history of PG, this guidance is based on a single cohort where most patients were diagnosed with Graves' disease prior to PG onset...
November 2023: Curēus
#23
Marah Mansour, Rania Almasri, Noura Amin, George Hamwi, Rawdah Attoum, Ilda Moafak Kanbour, Sara Mohammad Talal Jeniat, Samar AlKhrait
INTRODUCTION AND IMPORTANCE: Molar pregnancy is the most common type of gestational trophoblastic disease. It manifests as vaginal bleeding, accompanied by high levels of β-human chorionic gonadotropin (β-HCG). This case aims to highlight the importance of considering gestational trophoblastic disease as a potential diagnosis and its serious complications. CASE PRESENTATION: A 24-year-old female presented with vomiting, nausea, and no complaint of vaginal bleeding...
December 2023: Annals of Medicine and Surgery
#24
Laurel Walfish, Nisha Gupta, Dong Bach Nguyen, Mark Sherman
Hyperthyroidism due to gestational trophoblastic disease (GTD) is a rare but potentially life-threatening condition. Optimal perioperative management is crucial for favorable outcomes and prevention of thyroid storm. However, scarce data exist defining the ideal approach to this complex clinical presentation. This case report describes a first-time pregnant 32-year-old woman who was found to be biochemically hyperthyroid in the context of a 10-week gestation molar pregnancy. Despite her biochemical values, the patient remained clinically asymptomatic of her thyroid disease...
November 2023: JCEM Case Rep
#25
A Case of Aplasia Cutis Congenita in the Setting of Maternal Carbimazole Use in the First Trimester.
Colin McGrath, Nancy O'Hanrahan, Michael Conall Dennedy, Michael A Boyle
Aplasia cutis congenita (ACC) is one of several congenital malformations associated with antithyroid/thiourylene drug use in pregnancy. While uncommon among the general population (1-3/100 000 cases), the risk among those on thiourylenes is between 1.6% and 3%. The scalp is the most common site for this congenital anomaly. We present the case of a male infant with multifocal ACC of the scalp discovered at birth and born to a mother with Graves disease that was controlled during pregnancy using carbimazole. Thyroid function tests were normal throughout the pregnancy...
November 2023: JCEM Case Rep
#26
JOURNAL ARTICLE
Sijin Yang, Lijuan Wang, Hui Zhang, Ji Yang, Wenhui Li, Yijin Zhang
This study investigated the differences in the thermal preferences of pregnant women during various trimesters and the factors influencing these preferences. The survey was conducted in a hospital waiting room, encompassing the testing of thermal environmental parameters, and the distribution of questionnaires to pregnant women. These questionnaires encompassed various aspects, including basic information, thermal responses, pregnancy diseases, and more. In total, 1388 questionnaires were collected, distributed across the first trimester (225 participants), second trimester (498 participants), and third trimester (665 participants)...
October 29, 2023: Journal of Thermal Biology
#27
JOURNAL ARTICLE
Jiaming Liu, Xinglei Xie, Apolonia García-Patterson, Queralt Asla, Helena Sardà, Ana Chico, Juan M Adelantado, Eulàlia Urgell, Rosa Corcoy
PURPOSE: Gestational weight gain (GWG) is an important contributor to pregnancy outcomes in the general obstetric population and different subgroups. The corresponding information in women with thyroid conditions is limited. We aimed to evaluate the relationship between GWG according to institute of medicine (IOM) and pregnancy outcomes in women with thyroid disorders. METHODS: We performed a retrospective analysis of 620 pregnant women either treated with levothyroxine (N = 545) or attended because of hyperthyroidism during pregnancy (N = 75)...
November 19, 2023: Archives of Gynecology and Obstetrics
#28
JOURNAL ARTICLE
Haiyan Zheng, Qian Wang, Feng Chen
As previously demonstrated, serum beta-human chorionic gonadotropin (β-hCG) is linked to identifying early gestational abnormalities. This research was aimed at investigating the correlation between serum β-hCG levels and thyroid metabolic function in pregnant women with hyperemesis gravidarum (HG). Ninety-one pregnant women with HG were selected as the study group and divided into early pregnancy (EP), mid-pregnancy (MP), and late pregnancy (LP) groups according to their gestational weeks, while 84 normal pregnant women were selected as the control group...
2023: Chinese Journal of Physiology
#29
JOURNAL ARTICLE
Kyung Eun Lee, Ha Eun Oh, Sa Jin Kim, Geum Joon Cho, Min-Jeong Oh, Sung Won Han, Soo Bin Lee, Jae Eun Shin
OBJECTIVES: During pregnancy, many women develop thyroid disorders, which can result in fetal and neonatal development defects. We investigated whether maternal thyroid dysfunction would affect their children's growth and obesity. STUDY DESIGN: We conducted a nationwide population-based cohort study using a combination of data from several Korean nationwide registries to investigate the association between maternal thyroid dysfunction, offspring growth, and obesity...
December 2023: European Journal of Obstetrics, Gynecology, and Reproductive Biology
#30
Kara E Hensley, Christopher W Fiechter, Alysson Klein, Rhabia Hussein, Henry J Weiss, Mihail Zilbermint
We present a rare case of hydatidiform molar pregnancy, which led to the development of thyroid storm, followed by a rare complication of takotsubo cardiomyopathy in the setting of a COVID-19 infection. A 21-year-old female of 22 weeks gestational age presented with heavy vaginal blood loss, brown emesis, tachycardia, and lethargy. Through clinical presentation and ultrasound confirmation, a molar pregnancy was diagnosed. Laboratory data and clinical presentation of thyrotoxicosis supported a diagnosis of thyroid storm...
2023: Journal of Community Hospital Internal Medicine Perspectives
#31
JOURNAL ARTICLE
Rebecca Oelkrug, Lisbeth Harder, Mehdi Pedaran, Anne Hoffmann, Beke Kolms, Julica Inderhees, Sogol Gachkar, Julia Resch, Kornelia Johann, Olaf Jöhren, Kerstin Krause, Jens Mittag
It is well established that maternal thyroid hormones play an important role for the developing fetus; however, the consequences of maternal hyperthyroidism for the offspring remain poorly understood. Here we show in mice that maternal 3,3',5-triiodothyronine (T3) treatment during pregnancy leads to improved glucose tolerance in the adult male offspring and hyperactivity of brown adipose tissue (BAT) thermogenesis in both sexes starting early after birth. The activated BAT provides advantages upon cold exposure, reducing the strain on other thermogenic organs like muscle...
October 24, 2023: Nature Communications
#32
REVIEW
Marcio José Concepción-Zavaleta, Julia Cristina Coronado-Arroyo, Juan Eduardo Quiroz-Aldave, Luis Alberto Concepción-Urteaga, José Paz-Ibarra
INTRODUCTION: Female infertility is defined as the inability to achieve pregnancy following one year of consistent, unprotected sexual intercourse. Among the various endocrine factors contributing to this complex issue, thyroid dysfunction assumes a pivotal and noteworthy role. METHODS: A narrative review, encompassing 134 articles up to 2023, was conducted utilizing the PubMed/Medline, EMBASE, and Scielo databases. The primary focus of this review was to investigate the effects of thyroid dysfunction on female infertility...
November 2023: Diabetes & Metabolic Syndrome
#33
JOURNAL ARTICLE
Raghavendran Priyanka, Subbiah Sridhar, Baskaran Sumathi, Ashok Raja Jeyaraj, Vasanthiy Natarajan, Eagappan Subbiah, Kasthuri Santharam Raghavan, Jayaraman Sangumani
PURPOSE: The aim is to validate the third generation Thyrotropin receptor antibody (TRAb) assay for predicting neonatal thyroid dysfunction and adverse pregnancy outcomes in pregnant women with Graves' disease. METHODS: This prospective cohort study was conducted in TRAb positive pregnant women with Graves' disease and their off springs. The primary outcome was to assess different forms of neonatal thyroid dysfunction in relation to maternal and neonatal TRAb levels...
October 20, 2023: Endocrine
#34
JOURNAL ARTICLE
Emna Jelloul, Georgiana Sitoris, Flora Veltri, Pierre Kleynen, Serge Rozenberg, Kris G Poppe
OBJECTIVE: The aim of the study was to investigate the impact of suppressed serum TSH levels (sTSH) during early pregnancy on maternal and neonatal outcomes. METHODS: In this single-centre, retrospective cohort study 1081 women were screened at 11.8 ± 2.4 weeks of pregnancy for TSH, free T4 (FT4) and TPOAb. Exclusion criteria were twin- and assisted- reproduction pregnancies, women with TSH levels >3.74 mIU/L, severe hyperthyroidism, treated for thyroid dysfunction before or after screening and gestational blood sampling <6 or >16 weeks of pregnancy...
December 1, 2023: European Thyroid Journal
#35
REVIEW
Sun Y Lee, Elizabeth N Pearce
IMPORTANCE: Overt hyperthyroidism, defined as suppressed thyrotropin (previously thyroid-stimulating hormone) and high concentration of triiodothyronine (T3) and/or free thyroxine (FT4), affects approximately 0.2% to 1.4% of people worldwide. Subclinical hyperthyroidism, defined as low concentrations of thyrotropin and normal concentrations of T3 and FT4, affects approximately 0.7% to 1.4% of people worldwide. Untreated hyperthyroidism can cause cardiac arrhythmias, heart failure, osteoporosis, and adverse pregnancy outcomes...
October 17, 2023: JAMA
#36
JOURNAL ARTICLE
Inesse Ait Amara, Diana Bula-Ibula
OBJECTIVE: There is no specific recommendation for management in pregnant women: the aim of this review, based on a clinical case study, is to clarify its development, complications, risk factor and treatment. METHODS: A review of the literature was performed by consulting the Pubmed, Cochrane Library, and Science Direct databases. RESULTS: Primary hyperparathyroidism is defined as excessive production of parathyroid hormone resulting in hypercalcemia...
October 10, 2023: Gynecologie, Obstetrique, Fertilite & Senologie
#37
JOURNAL ARTICLE
Simona De Angelis, Emanuela Medda, Daniela Rotondi, Maria Masocco, Valentina Minardi, Benedetta Contoli, Valentina Possenti, Angela Sorbo, Marilena D'Amato, Anna Chiara Turco, Alberto Augusto Pastorelli, Paolo Stacchini, Roberto Da Cas, Marcello Bagnasco, Daniela Bonofiglio, Maurizio Gasperi, Domenico Meringolo, Caterina Mian, Mariacarla Moleti, Francesco Vermiglio, Efisio Puxeddu, Augusto Taccaliti, Massimo Tonacchera, Salvatore Ulisse, Antonio Dimida, Teresa Rago, Elena Nazzari, Mara Schiavo, Irene Bossert, Giacomo Sturniolo, Carlo Corbetta, Cristina Cereda, Laura Cappelletti, Marta Camilot, Francesca Teofoli, Renzo Ciatti, Elisabetta Tarsi, Nicola Perrotti, Onorina Marasco, Giovanna Scozzafava, Francesca Righetti, Sebastiano Andò, Stefania Catalano, Mariarosaria Cristofaro, Giovanni Sorrenti, Simona Censi, Silvia Morelli, Enke Baldini, Giuseppe Plutino, Roberto Copparoni, Elena Alonzo, Claudia Giacomozzi, Marco Silano, Antonella Olivieri
CONTEXT: In 2005, a nationwide program of iodine prophylaxis on voluntary basis was implemented in Italy by law. However, recent data on iodine status are lacking. OBJECTIVE: The aim of this study was to evaluate efficiency, effectiveness, and possible adverse effects (increased occurrence of thyroid autoimmunity and hyperthyroidism) of the Italian iodine prophylaxis program. METHODS: In the period 2015-2019 a nationwide survey was performed...
October 11, 2023: Journal of Clinical Endocrinology and Metabolism
#38
JOURNAL ARTICLE
Glòria Tena Vivó, Neus Parellada Esquius, Oriol Cunillera Puértolas, Mercè Albareda Riera, Mónica Isidro Albaladejo, Lluís Vila Ballester
OBJECTIVE: This study aimed to monitoring the prevalence of previously identified thyroid disorders and hypothyroidism monitoring before pregnancy. MATERIAL AND METHODS: A retrospective cross-sectional study of women whose pregnancies occurred between 2014 and 2016 was conducted, including 120,763 pregnancies in Catalonia (Spain). The presence of thyroid disorders in women was based on disease diagnostic codes and/or prescription of levothyroxine or antithyroid drugs...
2023: Frontiers in Endocrinology
#39
JOURNAL ARTICLE
Emna Jelloul, Georgiana Sitoris, Flora Veltri, Pierre Kleynen, Serge Rozenberg, Kris G Poppe
OBJECTIVE: To investigate the impact of suppressed serum TSH levels (sTSH) during early pregnancy on maternal and neonatal outcomes. METHODS: Single centre, retrospective cohort study in 1081 women screened at 11.8 ± 2.4 weeks of pregnancy for TSH, free T4 (FT4) and TPOAb. Exclusion criteria were twin- and assisted reproduction pregnancies, women with TSH levels >3.74 mIU/L, severe hyperthyroidism, treated for thyroid dysfunction before or after screening and gestational blood sampling <6 or >16 weeks of pregnancy...
October 1, 2023: European Thyroid Journal
#40
JOURNAL ARTICLE
Eman A Alotaibi, Adhwa M AlHaidar, Shahad A Alotaibi, Norah A Alshehri, Raghad A Alotaibi, Yaser Y Bashumeel, Reema Nassar, Mohammed A Batais
Objective This study investigates the prevalence and risk of thyroid disturbances in pregnant women with pre-existing diabetes mellitus (DM) or gestational diabetes mellitus (GDM) in a tertiary hospital setting in Riyadh, SA. This research's findings may help identify potential risk factors associated with thyroid disturbances during pregnancy and facilitate early diagnosis for at-risk pregnant women. Subjects and methods A retrospective cross-sectional study was conducted at an endocrinology clinic between October 2018 and December 2021 to evaluate the electronic records of pregnant women with DM or GDM who had documented normal thyroid function before pregnancy...
August 2023: Curēus
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