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hyperthyroidism pregnancy

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https://www.readbyqxmd.com/read/29142837/preoperative-management-in-patients-with-graves-disease
#1
REVIEW
Eliana Piantanida
Graves' disease is the most frequent cause of hyperthyroidism in iodine-sufficient geographical areas and is characterized by the presence in patients' serum of autoantibodies directed against the thyrotropin receptor (TRAb) that cause overproduction and release of thyroid hormones. Clinical presentation results from both hyperthyroidism and underlying autoimmunity. The diagnosis is based on characteristic clinical features and biochemical abnormalities. If serum thyrotropin (TSH) is low, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations should be measured to distinguish between subclinical (with normal circulating thyroid hormones) and overt hyperthyroidism (with increased circulating thyroid hormones)...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29137470/controversies-in-management-of-hyperthyroidism-during-pregnancy
#2
Fereidoun Azizi, Atieh Amouzegar
No abstract text is available yet for this article.
October 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29130077/study-of-the-factors-leading-to-fetal-and-neonatal-dysthyroidism-in-children-of-patients-with-graves-disease
#3
Maïa Banigé, Candice Estellat, Valerie Biran, Luc Desfrere, Valerie Champion, Alexandra Benachi, Yves Ville, Marc Dommergues, Pierre-Henri Jarreau, Mostafa Mokhtari, Claire Boithias, Frederic Brioude, Laurent Mandelbrot, Pierre-François Ceccaldi, Delphine Mitanchez, Michel Polak, Dominique Luton
Context: Neonatal hyperthyroidism was first described in 1912 and in 1964 was shown to be linked to transplacental passage of maternal antibodies. Few multicenter studies have described the perinatal factors leading to fetal and neonatal dysthyroidism. Objective: To show how fetal dysthyroidism (FD) and neonatal dysthyroidism (ND) can be predicted from perinatal variables, in particular, the levels of anti-thyrotropin receptor antibodies (TRAbs) circulating in the mother and child...
June 2017: J Endocr Soc
https://www.readbyqxmd.com/read/29067240/benign-thyroid-disease-in-pregnancy-a-state-of-the-art-review
#4
REVIEW
Efterpi Tingi, Akheel A Syed, Alexis Kyriacou, George Mastorakos, Angelos Kyriacou
Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase. Maternal thyroid dysfunction during pregnancy may have significant adverse maternal and fetal outcomes such as preterm delivery, preeclampsia, miscarriage and low birth weight. In this review we discuss the effect of thyroid disease on pregnancy and the current evidence on the management of different thyroid conditions in pregnancy and postpartum to improve fetal and neonatal outcomes, with special reference to existing guidelines on the topic which we dissect, critique and compare with each other...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29025533/negative-%C3%AE-hcg-and-molar-pregnancy-the-hook-effect
#5
Isabel Lobo Antunes, Joana Curado, Ana Quintas, Alcides Pereira
Molar pregnancy, included in gestational trophoblastic disease, is a benign pathology with ability to metastasize, usually occurring with excessively high βhCG levels. Clinical scenario is usually a woman in extremes of reproductive age presenting with amenorrhoea, pain and vaginal blood loss; signs derived from high βhCG levels may be present (hyperthyroidism, hyperemesis). Diagnosis is based on a positive pregnancy test - usually a qualitative urinary test. The limitation of this test results from its inability to become positive in presence of markedly high levels of βhCG, saturating the antigens used - known as the 'hook effect'...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28974300/the-treatment-of-illnesses-arising-in-pregnancy
#6
Michael Bolz, Sabine Körber, Toralf Reimer, Johannes Buchmann, Hans-Christof Schober, Volker Briese
BACKGROUND: The treatment of pregnant women who have illnesses unrelated to pregnancy can cause uncertainty among physicians. METHODS: We searched the PubMed database and specialty guidelines from Germany and abroad (the guidelines of the German Society for Gynecology and Obstetrics, the American Congress of Obstetri cians and Gynecologists, and the Royal College of Obstetricians and Gynaecologists) over the period 2007-2016 for information on standards for the diagnosis and treatment of five illnesses that can arise in pregnancy: bronchial asthma, migraine, hypothyroidism, hyperthyroidism, and varicose veins...
September 15, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28913145/subclinical-hypothyroidism-is-it-important-in-intracytoplasmic-sperm-injection-cycles
#7
Eray Çalışkan, Rahime Nida Ergin, Deniz Can Öztekin, Bülent Kars, Seda Çakır, Kenan Sofuoğlu
OBJECTIVE: To compare intracytoplasmic sperm injection (ICSI) outcomes of women with subclinical hypothyroidism with those of euthyroid women. MATERIALS AND METHODS: A retrospective case-control study was conducted. Out of 2529 ICSI cycles evaluated, 41 women with hypothyroidism, 28 women with hyperthyroidism, and 128 women with subclinical hyperthyroidism were excluded, and 2336 cycles were analyzed. Women were identified as having subclinical hypothyroidism (case group, n=105) in the presence of a thyroid-stimulating hormone level >4...
June 2017: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28892983/transient-thyrotoxicosis-in-molar-pregnancy
#8
Samarth Virmani, Sujatha B Srinivas, Rama Bhat, Raghavendra Rao, Ranjini Kudva
Molar pregnancy is one of the components of a broader spectrum of diseases known as Gestational Trophoblastic Disease (GTD), presenting with amenorrhoea and irregular bleeding which may be rarely associated with passage of vesicles per vagina. However, it can rarely be associated with hyperthyroidism, which may be associated with clinical features of hyperthyroidism. The following is a report of a 20-year-old woman who presented with amenorrhea followed by irregular bleeding per vagina, thyromegaly and abnormal levels of thyroid hormones...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28758357/thyroid-medication-use-and-birth-defects-in-the-national-birth-defects-prevention-study
#9
Meredith M Howley, Sarah C Fisher, Alissa R Van Zutphen, Dorothy K Waller, Suzan L Carmichael, Marilyn L Browne
BACKGROUND: Thyroid disorders are common among reproductive-aged women, with hypothyroidism affecting 2 to 3% of pregnancies, and hyperthyroidism affecting an additional 0.1 to 1%. We examined associations between thyroid medications and individual birth defects using data from the National Birth Defects Prevention Study (NBDPS). METHODS: The NBDPS is a multisite, population-based, case-control study that included pregnancies with estimated delivery dates from 1997 to 2011...
July 31, 2017: Birth defects research
https://www.readbyqxmd.com/read/28726182/autoimmune-hypothyroidism-is-three-times-more-frequent-in-female-prolactinoma-patients-compared-to-healthy-women-data-from-a-cross-sectional-case-control-study
#10
Atanaska Elenkova, Iliana Аtanasova, Georgi Кirilov, Еmil Natchev, Ralitza Ivanova, Roussanka Кovatcheva, Silvia Vandeva, Dimitar Tcharaktchiev, Sabina Zacharieva
BACKGROUND: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population. PURPOSE: A cross-sectional case-control study was carried out in a single tertiary referral centre. The main aim was to assess the frequency of newly diagnosed autoimmune thyroid diseases in female patients with prolactinomas...
September 2017: Endocrine
https://www.readbyqxmd.com/read/28713331/thyroid-stimulating-hormone-receptor-antibodies-in-pregnancy-clinical-relevance
#11
REVIEW
Ines Bucci, Cesidio Giuliani, Giorgio Napolitano
Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. TRAbs are heterogeneous for molecular and functional properties and are subdivided into activating (TSAbs), blocking (TBAbs), or neutral (N-TRAbs) depending on their effect on TSHR...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28671971/effects-of-methimazole-and-propylthiouracil-exposure-during-pregnancy-on-the-risk-of-neonatal-congenital-malformations-a-meta-analysis
#12
Rongjing Song, Hepu Lin, Yue Chen, Xiuying Zhang, Wanyu Feng
OBJECTIVE: The aim of this study was to determine the effect of exposure to different antithyroid drugs during pregnancy on the incidence of neonatal congenital malformations. METHODS: A meta-analysis was performed to compare the incidence of neonatal congenital malformations after exposure to different antithyroid drugs during pregnancy. Twelve studies that met the inclusion criteria were included in this meta-analysis. PubMed, Embase, and CENTRAL databases were searched from inception until January 2017...
2017: PloS One
https://www.readbyqxmd.com/read/28666083/maternal-thyroid-function-prepregnancy-obesity-and-gestational-weight-gain-the-generation-r-study-a-prospective-cohort-study
#13
Fernanda M Collares, Tim I M Korevaar, Albert Hofman, Eric A P Steegers, Robin P Peeters, Vincent W V Jaddoe, Romy Gaillard
OBJECTIVE: Maternal prepregnancy obesity and excessive gestational weight gain are associated with pregnancy complications. Thyroid function is related to differences in body mass index (BMI) in adult populations. We examined the associations of maternal thyroid function in early pregnancy with maternal BMI and weight gain during pregnancy. DESIGN AND METHODS: In a population-based prospective cohort study among 5726 mothers, we measured maternal TSH and FT4 levels at 13...
June 30, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28639966/risk-of-embryopathies-with-use-of-antithyroidal-medications
#14
Stine L Andersen
PURPOSE OF REVIEW: Hyperthyroidism in pregnant women should be adequately treated to prevent maternal and fetal complications. The treatment of choice in pregnancy is antithyroidal medications (ATDs). The risk of embryopathies associated with the use of Methimazole (MMI) and Propylthiouracil (PTU) in early pregnancy is a matter of clinical attention and concern. This review describes current evidence and how scientific findings are reflected in current clinical guidelines. RECENT FINDINGS: Embryopathies after the use of ATDs were previously mainly described in case reports and considered rare...
July 20, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28616924/-reference-intervals-of-thyroid-hormones-in-normal-pregnant-women-and-effects-of-thyroid-autoantibodies-on-thyroid-hormone-levels-in-pregnant-women-in-chengdu-area
#15
Yu-Min Chen, Jing Zeng, Yue-Rong Yan, Dan Luo, Lu Huang, Hui Huang
OBJECTIVES: To establish the reference intervals of thyroid hormones in normal pregnant women in Chengdu area of China, and to investigate the effects of thyroid autoantibodies on thyroid function in pregnant women. METHODS: We included 696 pregnant women who had gestation data from June 2013 to March 2014 in Chengdu Women & Children's Central Hospital. Every subject under went questionnaire survey, physical examination, thyroid ultrasound and measurement of thyroid hormone and thyroid autoantibodies...
May 2017: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28600040/anti-n-methyl-d-aspartate-receptor-nmdar-encephalitis-during-pregnancy-clinical-analysis-of-reported-cases
#16
Yan-Chao Shi, Xiu-Ju Chen, Hong-Mei Zhang, Zhen Wang, Da-Yong Du
OBJECTIVE: To analyze the clinical features of 13 pregnant patients with anti-N-Methyl-d-Aspartate receptor (NMDAR) encephalitis. MATERIALS AND METHODS: Retrospective review of thirteen reported cases was conducted for anti-NMDAR encephalitis patients during pregnancy. The clinical data were collected from papers published in PubMed prior to 16 February 2016. Statistical analysis of the data was performed, which encompasses the patients' age, past medical history, onset of symptoms, concomitant with ovarian teratomas, immunotherapy, outcomes of mothers and newborns...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28583776/-neonatal-hyperthyroidism-a-sometimes-challenging-diagnosis
#17
C Couturier, F Cneude, A Spiteri, F Nugues, T Debillon
Graves disease complicates two pregnancies out of 1000 and when it is known before pregnancy, it warrants careful monitoring of the fetus and the newborn. We report on a case of neonatal hyperthyroidism, which revealed a previously unknown maternal thyroid disease. In this situation, neonatal signs can be misinterpreted, delaying the diagnosis. Neonatal hyperthyroidism is, however, a therapeutic emergency because of the risk of cardiac and neurological complications. The neonatologist must identify thyroid disease in the absence of a maternal history in order to promptly start therapy...
July 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28522204/peg-interferon-plus-nucleotide-analogue-treatment-versus-no-treatment-in-patients-with-chronic-hepatitis-b-with-a-low-viral-load-a-randomised-controlled-open-label-trial
#18
Annikki de Niet, Louis Jansen, Femke Stelma, Sophie B Willemse, Sjoerd D Kuiken, Sebastiaan Weijer, Carin M J van Nieuwkerk, Hans L Zaaijer, Richard Molenkamp, R Bart Takkenberg, Maarten Koot, Joanne Verheij, Ulrich Beuers, Hendrik W Reesink
BACKGROUND: Antiviral treatment is currently not recommended for patients with chronic hepatitis B with a low viral load. However, they might benefit from acquiring a functional cure (hepatitis B surface antigen [HBsAg] loss with or without formation of antibodies against hepatitis B surface antigen [anti-HBs]). We assessed HBsAg loss during peg-interferon-alfa-2a (peg-IFN) and nucleotide analogue combination therapy in patients with chronic hepatitis B with a low viral load. METHODS: In this randomised controlled, open-label trial, patients were enrolled from the Academic Medical Center (AMC), Amsterdam, Netherlands...
May 15, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28489513/thyroid-function-during-early-life-and-dental-development
#19
S Vucic, T I M Korevaar, B Dhamo, V W V Jaddoe, R P Peeters, E B Wolvius, E M Ongkosuwito
Children with low levels of thyroid hormones (hypothyroidism) have delayed tooth eruption, enamel hypoplasia, micrognathia, and anterior open bite, whereas children with hyperthyroidism may suffer from accelerated tooth eruption, maxillary, and mandibular osteoporosis. However, it is still unknown whether thyroid function variations within the normal or subclinical range also have an impact on hard dental tissues in healthy children. The objective of this study was, therefore, to investigate the association between thyroid function from the fetal period until early childhood and dental development at school age...
August 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28485783/influence-of-screening-and-intervention-of-hyperthyroidism-on-pregnancy-outcome
#20
Y Wang, X-L Sun, C-L Wang, H-Y Zhang
OBJECTIVE: To discuss the influence of screening and intervention of hyperthyroidism on pregnancy outcome. PATIENTS AND METHODS: The clinical data of 122 pregnant women who had been confirmed with hyperthyroidism from April 2012 to July 2014 in the Weifang People's Hospital were analyzed retrospectively (25 untreated, 97 treated). 60 with normal pregnancy check were randomly selected as control group. The pregnancy outcomes of the two groups of patients were analyzed...
April 2017: European Review for Medical and Pharmacological Sciences
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