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https://www.readbyqxmd.com/read/29678783/safety-and-efficacy-of-stereotactic-radioablation-targeting-pulmonary-vein-tissues-in-an-experimental-model
#1
Paul C Zei, Doug Wong, Edward Gardner, Thomas Fogarty, Patrick Maguire
BACKGROUND: Stereotactic radioablation (SR), a commonly used therapy to treat malignancies, has been utilized to treat refractory ventricular tachycardia, but the feasibility of treating atrial fibrillation (AF) with SR is unknown. OBJECTIVE: We evaluated the safety and efficacy of SR targeting pulmonary vein (PV) antral tissues as potential therapy for AF. METHODS: Seventeen adult canines and two adult swine underwent surgical fiducial marker placement, 3D anatomic rendering CT angiogram of the left atrium (LA), and creation of a treatment plan targeting the right superior pulmonary veins (RSPVs)...
April 17, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29676680/midline-central-fluid-percussion-model-of-traumatic-brain-injury-in-pediatric-and-adolescent-rats
#2
Rachel K Rowe, Jordan L Harrison, Timothy W Ellis, P David Adelson, Jonathan Lifshitz
OBJECTIVE Experimental traumatic brain injury (TBI) models hold significant validity to the human condition, with each model replicating a subset of clinical features and symptoms. TBI is the leading cause of mortality and morbidity in children and teenagers; thus, it is critical to develop preclinical models of these ages to test emerging treatments. Midline fluid percussion injury (FPI) might best represent mild and diffuse clinical brain injury because of the acute behavioral deficits, the late onset of behavioral morbidities, and the absence of gross histopathology...
April 20, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29676193/to-fidget-or-not-to-fidget-that-is-the-question-a-systematic-classroom-evaluation-of-fidget-spinners-among-young-children-with-adhd
#3
Paulo A Graziano, Alexis M Garcia, Taylor D Landis
OBJECTIVE: To examine how fidget spinners affect children with ADHD's gross motor activity and attentional functioning in class, both during the initial and final phase of an intensive evidence-based behavioral treatment. METHOD: Using an A-B-A-B design, 60 children ( Mage = 4.86 years, 83% Hispanic) diagnosed with ADHD participated in the study. Following a baseline period, four random children from each classroom were given fidget spinners across three separate days ( n = 48)...
April 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29674784/bat-wing-biometrics-using-collagen-elastin-bundles-in-bat-wings-as-a-unique-individual-identifier
#4
Sybill K Amelon, Sarah E Hooper, Kathryn M Womack
The ability to recognize individuals within an animal population is fundamental to conservation and management. Identification of individual bats has relied on artificial marking techniques that may negatively affect the survival and alter the behavior of individuals. Biometric systems use biological characteristics to identify individuals. The field of animal biometrics has expanded to include recognition of individuals based upon various morphologies and phenotypic variations including pelage patterns, tail flukes, and whisker arrangement...
May 29, 2017: Journal of Mammalogy
https://www.readbyqxmd.com/read/29674109/mixed-method-evaluation-of-a-cadaver-dissection-course-for-general-surgery-interns-an-innovative-approach-for-filling-the-gap-between-gross-anatomy-and-the-operating-room
#5
Yen-Yi Juo, Christina Hanna, Quach Chi, Grace Chang, Warwick J Peacock, Areti Tillou, Catherine E Lewis
OBJECTIVE: To evaluate an innovative whole cadaver dissection curriculum designed to focus on teaching procedure-relevant anatomy and surgical skills to surgery interns. DESIGN: A mixed methods explanatory sequential design incorporating both quantitative and qualitative evaluations was used to evaluate the cadaver dissection course. Quantitative data were prospectively collected and retrospectively reviewed in order to compare anatomy knowledge and operative skills before and after the course...
April 16, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29673420/neurologic-complications-associated-with-transdermal-placement-of-intrathecal-catheters-in-sheep
#6
Gabrielle C Musk, Nolan J McDonnell, Mark Newman, Matthew W Kemp
A study using an ovine model of transdermal intrathecal catheterization was planned to investigate the neurotoxicity ofmagnesium sulfate. Nonpregnant Merino cross ewes (n = 8; age, 5 y; weight, 55.0 ± 6.5 kg) were anesthetized for placementof a lumbar intrathecal catheter. The study protocol defined a 5-d recovery period after introduction of the catheter before theadministration of test substances (2 mL of 0.9% saline or 50 or 150 mg MgSO4) followed by euthanasia 1 wk later. Although 3sheep successfully completed the study as planned, one of the remaining 5 sheep was withdrawn when the catheter was accidentally dislodged 2 d after anesthesia; another was withdrawn because of persistent neurologic deficits of the left hindlimb and intense pruritus during the first 24 h after placement of the catheter; and the remaining 3 animals experienced unacceptable complications within the first 4 h of administration of the test substance...
April 19, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29673348/path-analysis-of-strength-spasticity-gross-motor-function-and-health-related-quality-of-life-in-children-with-spastic-cerebral-palsy
#7
Eun-Young Park
BACKGROUND: Measures of health-related quality of life may predict the future status of individuals with illnesses, and could therefore be a good indicator in children with cerebral palsy (CP). This study examines the causal relationship between spasticity, weakness, gross motor function, and health-related quality of life (QOL) in school-aged children with spastic CP and tests models of functional outcome mediated by gross motor function. METHODS: A total of 62 children (44 males, 18 females) with spastic CP were recruited...
April 19, 2018: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/29672175/comparison-of-hidden-blood-loss-between-three-different-surgical-approaches-for-treatment-of-thoracolumbar-fracture
#8
Ze-Xin Chen, Ze-Ming Sun, Chao Jiang, Hui Zhang, Min-Ji Tong, Yan Lin, Yao-Sen Wu
PURPOSE: To examine the hidden blood loss (HBL) in treatment of AO type A1-A3 thoracolumbar fractures with three different approaches and to explore the influential factors of HBL among patients after the surgery of internal fixation for thoracolumbar fractures. METHODS: We retrospectively studied 85 patients in treatment of thoracolumbar fractures: 25 patients via percutaneous approach (Group A), 33 patients via paraspinal approach (Group B), and 27 patients via conventional open approach (Group C)...
April 19, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29671179/clinical-infection-in-house-rats-rattus-rattus-caused-by-streptobacillus-notomytis
#9
Viktoria Michel, Claudia Ulber, Dietrich Pöhle, Beate Köpke, Katharina Engel, Ute Kaim, Ahmad Fawzy, Sophie Funk, Juliane Fornefett, Christoph Georg Baums, Tobias Eisenberg
Rat bite fever is an under-reported, under-diagnosed emerging zoonosis with worldwide distribution. Besides Spirillum minus, Streptobacillus moniliformis is the major causative microorganism although it usually colonises rats without any clinical signs. A group of house rats (Rattus rattus) kept in a zoo exhibition for educational purposes suffered from neurological signs including disorientation, torticollis, stall walking, ataxia and death. Gross pathological and histo-pathological examinations of the investigated rats revealed high-grade otitis interna et media, from which Streptobacillus notomytis was isolated in pure culture or as the predominant microorganism...
April 18, 2018: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29671047/atypical-outbreak-of-acute-coenurosis-by-taenia-multiceps-in-a-sheep-flock
#10
Davide Pintus, Antonio Varcasia, Giorgia Dessì, Claudia Tamponi, Maria Lucia Manunta, Giovanni Antonio Carboni, Maria Giovanna Cancedda, Ciriaco Ligios, Antonio Scala
Herein, we examined the brain of adult ewes and lambs less than 30 days old which were found affected by neurological signs in a flock located in Sardinia (Italy). Gross anatomo-pathological examination of all brains of the animals revealed multiple linear reddish-yellow foci of necrotic purulent inflammation due to oncosphere migration. Histologically, we confirmed a multifocal pyo-granulomatous meningo-encephalitis both in ewes and in lambs, confirming acute coenurosis. Morphological examination and DNA sequencing identified the Taenia multiceps we isolated as Tm1 strain...
April 18, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29670715/the-effect-of-surface-topographical-changes-of-two-different-surface-treatments-rotary-instrument
#11
Nashwan-Ahmed Qaed, Bilal-Diab Mourshed, Hashem-Motahir Al-Shamiri, Nader Alaizari, Saleh-Sulaiman Alhamdah
Background: One of the major innovations in endodontics has been the introduction of nickel-titanium (NiTi) alloy. This study evaluated the surface topographical changes of two different surface treatments rotary instrument after instrumentation and sterilization. Material and Methods: 240 Extracted teeth were included in this study. 90 new AlphaKite and Revo-S NiTi rotary instruments were selected and divided into two groups (Group A 45 AlphaKite and group B 45 Revo-S)...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29669235/histological-observations-on-adipocere-in-human-remains-buried-for-21-years-at-the-toma%C3%A5-ica-grave-site-in-bosnia-and-herzegovina
#12
Adis Salihbegović, John Clark, Nermin Sarajlić, Svjetlana Radović, Finlay Finlay, Anes Jogunčić, Emina Spahić, Vedo Tuco
The Tomašica grave-site near Prijedor in the north of Bosnia is reported to be the largest primary mass grave discovered thus far relating to the 1992-95 war. A total of 275 complete bodies and 125 body parts were exhumed from it in 2013. Post mortem examinations of the victims showed that nearly all had died from gunshot injuries but an additional striking feature was the degree of preservation of many of the bodies, even 21 years on, with skin, soft tissues and internal organs still present in abundance and gross structures clearly identifiable...
April 18, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29666316/patterns-of-plant-carbon-nitrogen-and-phosphorus-concentration-in-relation-to-productivity-in-china-s-terrestrial-ecosystems
#13
Zhiyao Tang, Wenting Xu, Guoyi Zhou, Yongfei Bai, Jiaxiang Li, Xuli Tang, Dima Chen, Qing Liu, Wenhong Ma, Gaoming Xiong, Honglin He, Nianpeng He, Yanpei Guo, Qiang Guo, Jiangling Zhu, Wenxuan Han, Huifeng Hu, Jingyun Fang, Zongqiang Xie
Plant nitrogen (N) and phosphorus (P) content regulate productivity and carbon (C) sequestration in terrestrial ecosystems. Estimates of the allocation of N and P content in plant tissues and the relationship between nutrient content and photosynthetic capacity are critical to predicting future ecosystem C sequestration under global change. In this study, by investigating the nutrient concentrations of plant leaves, stems, and roots across China's terrestrial biomes, we document large-scale patterns of community-level concentrations of C, N, and P...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29661130/a-survey-of-functional-genomic-variation-in-domesticated-chickens
#14
Martijn F L Derks, Hendrik-Jan Megens, Mirte Bosse, Jeroen Visscher, Katrijn Peeters, Marco C A M Bink, Addie Vereijken, Christian Gross, Dick de Ridder, Marcel J T Reinders, Martien A M Groenen
BACKGROUND: Deleterious genetic variation can increase in frequency as a result of mutations, genetic drift, and genetic hitchhiking. Although individual effects are often small, the cumulative effect of deleterious genetic variation can impact population fitness substantially. In this study, we examined the genome of commercial purebred chicken lines for deleterious and functional variations, combining genotype and whole-genome sequence data. RESULTS: We analysed over 22,000 animals that were genotyped on a 60 K SNP chip from four purebred lines (two white egg and two brown egg layer lines) and two crossbred lines...
April 16, 2018: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/29659329/cost-effectiveness-analyses-of-the-21-gene-assay-in-breast-cancer-systematic-review-and-critical-appraisal
#15
Shi-Yi Wang, Weixiong Dang, Ilana Richman, Sarah S Mougalian, Suzanne B Evans, Cary P Gross
Purpose Prior studies examining cost effectiveness of the 21-gene assay (Oncotype DX [ODX]) for women with hormone receptor-positive, early-stage breast cancer have yielded disparate results. We aimed to explore why these analyses may have yielded different conclusions. Methods We conducted a systematic literature review of cost-effectiveness analyses (CEAs) of ODX. We examined the extent to which the structure of CEA modeling, the assumptions of the models, and the selection of input parameters influenced cost-effectiveness estimates...
April 16, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29659197/morphological-features-of-the-branching-pattern-of-the-hypoglossal-nerve
#16
Yujiro Sakamoto
The hypoglossal or twelfth cranial nerve is the motor nerve to the extrinsic and intrinsic muscles of the tongue, and the superior root of the ansa cervicalis and the thyrohyoid and geniohyoid branches are delivered through the nerve. This study investigated the muscular branches of the hypoglossal nerve to clarify their spatial relationships with the muscles of the tongue and the neighboring structures. The muscles and the nerve were gross anatomically examined in 42 cadavers. The superior root and the thyrohyoid branch left the nerve near the occipital and lingual arteries, respectively...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29658831/short-burst-interval-treadmill-training-walking-capacity-and-performance-in-cerebral-palsy-a-pilot-study
#17
Kristie F Bjornson, Noelle Moreau, Amy Winter Bodkin
PURPOSE: To examine the effect of short-burst interval locomotor treadmill training (SBLTT) on walking capacity and performance in cerebral palsy (CP). METHODS: Twelve children with spastic diplegic CP (average 8.6 years) across Gross Motor Function Classification System levels II (8) and III (4) were randomized to 20 SBLTT sessions over 4 or 10 weeks. SBLTT consisted of alternating 30 seconds of slow and fast walking for 30 minutes/session. Outcomes included the 10 m walk test, one-minute walk test (1MWT), and timed-up-and go (TUG) (capacity) and StepWatch (performance) collected at baseline, post, and 6 weeks post...
April 16, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29658680/rectal-cancer-and-the-pathologist
#18
Mariana Berho, Pablo A Bejarano
INTRODUCTION: Examination of the rectum by pathologists is instrumental in the management of patients affected by rectal carcinoma. That role includes evaluation of multiple gross and microscopic features that convey prognostic implications. EVIDENCE ACQUISITION: The analysis is based on the authors' experience handling rectal specimens along with review of the pertinent literature in these areas: margins of excision, quality of the mesorectum, diligence and techniques to sample lymph nodes, tumor budding, grading of residual amount of carcinoma after pre-operative therapy, vascular/perineural invasion, and staging the tumor...
April 13, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29656325/dosing-of-the-second-generation-cryoballoon-using-acute-time-to-pulmonary-vein-isolation-as-an-indicator-of-durable-ablation-in-a-canine-model
#19
Wilber Su, Nicolas Coulombe, Nicole Kirchhof, Erin Grassl, Dan Wittenberger
BACKGROUND: Rigid time-based dosing protocol(s) currently used in the clinic for cryoballoon ablation of atrial fibrillation may be inadequate to guide the circumferential and transmural cryothermal energy transfer across the pulmonary vein (PV) and may result in injury to collateral tissues or electrical gaps between the PV and left atrium (LA). OBJECTIVE: A physiologic endpoint (e.g., acute time-to-PV isolation a.k.a. time-to-effect; TTE) may be effective in the determination of a transmural lesion formation and may allow for individualized ablation dosing across each PV...
April 14, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29655856/acute-and-subchronic-toxicities-in-dogs-and-genotoxicity-of-honokiol-microemulsion
#20
Xiujun Qin, Jingjing Yin, Wei Zhang, Jianguo Li, Jianhua Wen, Shizhong Chen
This article aims to conduct toxicity test research on honokiol microemulsion(HM) to provide reference frame for the safe dose design as well as the toxic and adverse reaction monitoring in clinic. High performance liquid chromatography (HPLC) method was adopted to determine the concentration, stability and uniformity of HM and the results indicated that the test sample was conformed to the toxicity test requirements. In the acute toxicity test, six intravenous drip dosages, namely, 100.0, 66.7, 44.4, 19.8, 8...
April 12, 2018: Regulatory Toxicology and Pharmacology: RTP
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