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Gross examination

Asangi R Kumarapeli, William Bellamy, Ericka Olgaard, Nicole Massoll, Soheila Korourian
CONTEXT: - A thorough gross examination of specimens for breast cancer requires the tissue to be very thinly sectioned, which is often difficult in large mastectomy samples. We have implemented rapid chilling of mastectomy specimens before formalin fixation. OBJECTIVE: - To evaluate the effects of rapid chilling of breast tissue on subsequent biomarker and molecular testing. DESIGN: - Mastectomy specimens were chilled at -80°C for 20 minutes to facilitate uniform sectioning of tissue at 4-mm intervals and enhance proper fixation and identification of small lesions...
June 22, 2018: Archives of Pathology & Laboratory Medicine
L J Wang, Z Li, M Li, L Weng, W H Li, J DU, J Z Zhang
Pigmented extramammary Paget's disease (PEMPD) is an uncommon intraepithelial adenocarcinoma and a rare variant of Paget's disease, characterized as a superficial pigmented scaly macule clinically and an increased number of melanocytes scattered between the Paget's cells histologically. So it may be confused clinically and histologically with melanocytic tumors, dermatitis and other dermatoses. Different therapeutic attitudes are required in this case of adenocarcinoma in situ as opposed to melanoma and dermatitis...
June 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Erin M Harvey, Eileen R McGrath, Joseph M Miller, Amy L Davis, J Daniel Twelker, Leslie K Dennis
PURPOSE: To determine whether uncorrected astigmatism in toddlers is associated with poorer performance on the Bayley Scales of Infant and Toddler Development, 3rd edition (BSITD-III). METHODS: Subjects were 12- to 35-month-olds who failed an instrument-based vision screening at a well-child check. A cycloplegic eye examination was conducted. Full-term children with no known medical or developmental conditions were invited to participate in a BSITD-III assessment conducted by an examiner masked to the child's eye examination results...
June 18, 2018: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Arnas Bakavičius, Marija Barisienė, Marius Snicorius, Dileta Valančienė, Darius Dasevičius, Algirdas Žalimas, Robertas Kvaščevičius, Henrikas Ramonas, Vitalijus Sokolovas, Feliksas Jankevičius
Introduction: Mixed epithelial and stromal tumour of the kidney (MEST) is a rare and distinctive neoplasm accounting for 0.2% of all renal cancers. Most of these tumours behave in a benign fashion but 13 cases with malignant transformation have already been reported. We present the first case of an extremely aggressive MEST with rapid recurrence after radical treatment, demonstrating objective response to chemotherapy. Case presentation: A 31-year-old female presented to the hospital complaining of gross hematuria...
2018: Acta Medica Lituanica
Lauren P Cleveland, Denise Simon, Jason P Block
OBJECTIVES: To examine early compliance with the delayed federal calorie labeling regulation that requires posting calories on menus and menu boards at retail food chains with 20 or more establishments nationally. METHODS: We explored implementation of calorie labeling at 90 of the largest US chain restaurants and the 10 highest-grossing supermarket chains from May to December 2017. We contacted corporate offices and at least 2 locations for each chain, made site visits when possible, and supplemented these efforts with targeted Internet searches...
June 21, 2018: American Journal of Public Health
Stevie-Jo Maher, Nadja Schott, Natalie J Lander, Trina Hinkley, Lisa M Barnett
BACKGROUND/AIM: Parent proxy reports are well used in occupational therapy, yet historically parent report instruments of motor skill have not required parents to report on the same motor skills that their children are assessed on. The aim was to examine how well a parent report of children's fundamental movement skill (FMS) was associated with children's actual FMS. METHOD: A sample of 100 children aged 7-9 years from Melbourne, Australia, were recruited. Parents/guardians completed proxy report (parent version of the 'Pictorial Scale of Perceived Movement Skill Competence' (PMSC)) and children's actual motor skills were assessed ('Test of Gross Motor Development' 3rd edition (TGMD-3))...
June 21, 2018: Australian Occupational Therapy Journal
Hong Yan, Furong Wang, Lin Xiang, Wei Zhu, Cheng Liang
RATIONALE: Diffuse giant cell tumors of the tendon sheath (GCT-TS) in the temporomandibular joint (TMJ) are extremely rare. PATIENT CONCERNS: We reported the imaging appearance and the pathological findings of 2 male cases with diffuse GCT-TS in the TMJ (52 years for the case 1 and 50 years for the case 2) who complain of the hearing disorders of left ear when presenting to our hospital. DIAGNOSIS: Preoperative computerized tomography (CT) scan revealed an irregular mass in the left temporal fossa with the sizes of approximately 5...
June 2018: Medicine (Baltimore)
Thomas Hermanns, Nico C Grossmann, Marian S Wettstein, Etienne X Keller, Christian D Fankhauser, Oliver Gross, Benedikt Kranzbühler, Martin Lüscher, Alexander H Meier, Tullio Sulser, Cédric Poyet
PURPOSE: To investigate whether heat-induced fiber degradation and loss of power output, which occurred during GreenLight laser vaporization (LV) of the prostate using the first- and second-generation 80 and 120 W laser, are still an issue during LV using the upgraded third generation 180 W GreenLight XPS™ laser. METHODS: Laser beam power output of 53 laser fibers was measured at baseline and after every 25 kJ of delivered energy during routine 180 W GreenLight XPS™ LV in 47 patients with prostatic bladder outflow obstruction...
June 19, 2018: World Journal of Urology
Cornelia Putz, Ann- Kathrin Blessing, Sarah Erhard, Katharina Fiethen, Andreas Geisbüsch, Mirjam Niklasch, Leonhard Döderlein, Sebastian Immanuel Wolf, Thomas Dreher
BACKGROUND: Deterioration of gait in adolescent and adult patients with cerebral palsy can be associated with multiple factors. Multilevel surgery (MLS) is one option in adults with cerebral palsy to improve gait function with encouraging short-term results. It is a question whether these improvements are maintained over time. METHODS: In a retrospective consecutive cohort study, adults with bilateral spastic cerebral palsy (BSCP) treated with MLS between 1995 and 2011 were scanned for potential inclusion...
June 20, 2018: International Orthopaedics
Brittany L Aguilar, Patrick A Forcelli, Ludise Malkova
The basal ganglia are an evolutionarily old group of structures, with gross organization conserved across species. Despite this conservation, there is evidence suggesting that anatomical organization of a key output nucleus of the basal ganglia, the substantia nigra pars reticulata (SNpr), diverges across species. Nevertheless, there are relatively few comparative studies examining the impact of manipulations of SNpr across species. Here, we evaluated the role of SNpr in a highly conserved behavior: prepulse inhibition of the acoustic startle response (PPI)...
June 19, 2018: Scientific Reports
William Brady Little, Elpida Artemiou, Anne Conan, Cathryn Sparks
Although cadaveric dissection has historically been the cornerstone of anatomical education, it comes at the cost of some emotional, moral, safety, and environmental concerns. Computer assisted learning (CAL) programs are an increasingly common solution to these issues; however, research regarding the efficacy of high fidelity simulation is limited. The traditional first semester veterinary gross anatomy course curriculum at Ross University School of Veterinary Medicine (RUSVM) was supplemented with a web based virtual anatomy program, IVALA™ (www...
June 19, 2018: Veterinary Sciences
Mohammad R Khan, Jayesh Dudhia, Frederic H David, Roberta De Godoy, Vedika Mehra, Gillian Hughes, Stephanie G Dakin, Andrew J Carr, Allen E Goodship, Roger K W Smith
BACKGROUND: Intra-synovial tendon injuries display poor healing, which often results in reduced functionality and pain. A lack of effective therapeutic options has led to experimental approaches to augment natural tendon repair with autologous mesenchymal stem cells (MSCs) although the effects of the intra-synovial environment on the distribution, engraftment and functionality of implanted MSCs is not known. This study utilised a novel sheep model which, although in an anatomically different location, more accurately mimics the mechanical and synovial environment of the human rotator cuff, to determine the effects of intra-synovial implantation of MSCs...
June 19, 2018: Stem Cell Research & Therapy
Jocelyn M Moulton, Crystal Cole, Nicola D Ridgers, Genevieve Pepin, Lisa M Barnett
BACKGROUND/AIM: The aim of this study was to determine the face validity and the reliability of a pictorial scale to assess preschool children's perceived movement skills. METHODS: The pictorial scale examines the perceptions of the 12 fundamental movement skills presented in the Test of Gross Motor Development-2 (six locomotor and six object control skills) and six active play skills (e.g. cycling). A total of 91 Australian children aged four to five years from 14 preschools completed the scale on two occasions to determine test-retest reliability...
June 19, 2018: Australian Occupational Therapy Journal
Antoine Schernberg, Sophie Bockel, Pierre Annede, Ingrid Fumagalli, Alexandre Escande, Fabien Mignot, Manon Kissel, Philippe Morice, Enrica Bentivegna, Sebastien Gouy, Eric Deutsch, Christine Haie-Meder, Cyrus Chargari
OBJECTIVE: To study the prognostic value of gross tumor volume (GTV) shrinkage and its dosimetric implication in a large cohort of cervical cancer patients receiving definitive chemoradiotherapy plus image-guided adaptive brachytherapy (IGABT). MATERIALS AND METHODS: Clinical records of consecutive patients treated in our Institution between February 2004 and November 2015 by concurrent chemoradiotherapy (45Gy in 25 fractions +/- lymph node boosts) followed by a magnetic resonance imaging (MRI)-guided adaptive pulse-dose rate brachytherapy were included...
June 16, 2018: International Journal of Radiation Oncology, Biology, Physics
S A Martinson, S J Greenwood, D Wadowska, K Martin
Microsporidial spores were identified in the musculature of a loggerhead sea turtle Caretta caretta found dead on the shore in New Brunswick, Canada. Gastroenteritis was diagnosed on gross postmortem examination, with no gross abnormalities detected in the skeletal muscle. Histologically, the microsporidial spores were associated with inflammation and muscular necrosis and measured 1.1-1.7 × 2.2-3.4 µm. Spores were typically identified within sporophorous vesicles and, less often, in sporophorocysts and were weakly Gram positive, had punctate PAS staining, and were occasionally strongly acid-fast...
June 19, 2018: Diseases of Aquatic Organisms
Esteban Soto, Matt J Griffin, Juan Alberto Morales, Elías Barquero Calvo, Fernanda de Alexandre Sebastião, Adrián Lopez Porras, Xindy Víquez-Rodríguez, Stephen R Reichley, Thomas G Rosser, Cynthia Ware, Barbara A Byrne, Julio C García, Benjamin R LaFrentz, Alvin C Camus
Historically, piscine francisellosis in various warm, temperate and coldwater fish hosts has been attributed to Francisella noatunensis From 2015-2016, an undescribed Francisella sp. was recovered during mortality events in cultured spotted rose snapper ( Lutjanus guttatus ) off the Pacific coast of Central America. Despite high mortality and emaciation, limited gross findings were observed in affected fish. Histological examination revealed multifocal granulomatous lesions, with the presence of numerous small, pleomorphic coccobacilli, predominantly in the peritoneum, spleen, kidneys, liver, pancreas, heart, and intestine...
June 18, 2018: Applied and Environmental Microbiology
Raquel A S Cruz, Wagner B Rodrigues, Simone Silveira, Victor H S Oliveira, Camila Gonçalves Campos, Ronaldo V Leite Filho, Fabiana M Boabaid, David Driemeier, Cláudio W Canal, Amauri A Alfieri, Caroline A Pescador, Edson M Colodel
A HoBi-like pestivirus was first described in 2004 in a Brazilian fetal bovine serum that was exported to Germany. Nevertheless, it is believed that the virus had been present since the 1990's, when it was detected in buffalos of Brazilian origin. Reproductive and respiratory diseases have been reported since 2001 in cattle, and more recently, diseases accompanied by a clinical presentation of mucosal disease-like (MD-like lesions have been reported as well. In the present study, the authors reported the oldest case of MD--like in cattle, associated with a HoBi-like pestivirus infection...
June 11, 2018: Research in Veterinary Science
Andrew Miller, Narelle Eather, Mitch Duncan, David Revalds Lubans
This study investigated if object control relates to children's game play competence, and examined these competencies as correlates of physical activity and cardiorespiratory fitness. Game play (Game Performance Assessment Instrument), object control (The Test Gross Motor Development-3), moderate-to-vigorous physical activity (Accelerometry), and cardiorespiratory fitness (20-metre shuttle) assessments were completed for 107 children (57% Female, 43% Male) aged 9-12 years (M 10.53, SD 0.65). Two-level regression of object control on game play competence, and object control and game play competence on physical activity and cardiorespiratory fitness assessed associations...
June 18, 2018: Journal of Sports Sciences
Caitlin E Moss, Andrew Robson, Erol Fikrig, Sukanya Narasimhan
Infectious diseases transmitted by arthropod vectors continue to pose a significant threat to human health worldwide. The pathogens causing these diseases, do not exist in isolation when they colonize the vector; rather, they likely engage in interactions with resident microorganisms in the gut lumen. The vector microbiota has been demonstrated to play an important role in pathogen transmission for several vector-borne diseases. Whether resident bacteria in the gut of the Ixodes scapularis tick, the vector of several human pathogens including Borrelia burgdorferi, influence tick transmission of pathogens is not determined...
June 1, 2018: Journal of Visualized Experiments: JoVE
Chia-Ing Jan, Wan-Chen Tsai, Horng-Jyh Harn, Woei-Cherng Shyu, Ming-Chao Liu, Hsin-Man Lu, Shao-Chih Chiu, Der-Yang Cho
Background: Glioblastoma (GBM) is the most common and lethal primary malignant glioma in adults. Dendritic cell (DC) vaccines have demonstrated promising results in GBM clinical trials. However, some patients do not respond well to DC therapy, with survival rates similar to those of conventional therapy. We retrospectively analyzed clinical and laboratory data to evaluate the factors affecting vaccine treatment. Methods: Forty-seven patients with de novo GBM were enrolled at China Medical University Hospital between 2005 and 2010 and divided into two subgroups...
2018: Frontiers in Immunology
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