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https://www.readbyqxmd.com/read/28647804/estimating-the-long-term-functional-burden-of-osteoporosis-related-fractures
#1
S Fischer, K A Kapinos, A Mulcahy, L Pinto, O Hayden, R Barron
Although fractures are associated with short-term reductions in functional status, there is limited information on longer-term burden of fracture. This study documents evidence of an association between fractures and significant declines and functional health and activities that persist but attenuate beyond two years. INTRODUCTION: Although fractures are associated with short-term reductions in functional status and may have other short-term effects on healthcare utilization (hospitalization and follow-up care), there is limited information on long-term burden of fracture beyond 12 to 24 months post-fracture...
June 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28647792/regeneration-of-hyaline-cartilage-promoted-by-xenogeneic-mesenchymal-stromal-cells-embedded-within-elastin-like-recombinamer-based-bioactive-hydrogels
#2
David Pescador, Arturo Ibáñez-Fonseca, Fermín Sánchez-Guijo, Jesús G Briñón, Francisco Javier Arias, Sandra Muntión, Cristina Hernández, Alessandra Girotti, Matilde Alonso, María Consuelo Del Cañizo, José Carlos Rodríguez-Cabello, Juan Francisco Blanco
Over the last decades, novel therapeutic tools for osteochondral regeneration have arisen from the combination of mesenchymal stromal cells (MSCs) and highly specialized smart biomaterials, such as hydrogel-forming elastin-like recombinamers (ELRs), which could serve as cell-carriers. Herein, we evaluate the delivery of xenogeneic human MSCs (hMSCs) within an injectable ELR-based hydrogel carrier for osteochondral regeneration in rabbits. First, a critical-size osteochondral defect was created in the femora of the animals and subsequently filled with the ELR-based hydrogel alone or with embedded hMSCs...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28647654/the-clinical-features-and-surgical-outcomes-of-spinal-cord-tanycytic-ependymomas-a-report-of-40-cases
#3
Xiaogang Tao, Zonggang Hou, Shuyu Hao, Qi Zhang, Zhen Wu, Junting Zhang, Baiyun Liu
OBJECTIVE: Spinal cord tanycytic ependymomas (TEs) are rarely reported because of extremely low incidence. Understanding of this disease is therefore poor. The aim of this study was to analyze the incidence and clinical, radiological, pathological, and prognostic features of spinal cord TEs. METHODS: Approximately 4,000 spinal cord tumors were surgically resected in Beijing Tiantan Hospital between April 2009 and May 2016. We identified all cases of pathologically proved TEs among these patients...
June 21, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28647549/motivational-interviewing-improves-sustainable-return-to-work-in-injured-workers-after-rehabilitation-a-cluster-randomized-controlled-trial
#4
Douglas P Gross, Joanne Park, Fahreen Rayani, Colleen M Norris, Shaniff Esmail
OBJECTIVE: To examine whether motivational interviewing (MI) leads to more sustainable return-to-work outcomes for injured workers undergoing rehabilitation. MI is a client-centred counselling approach that facilitates behavioural change through identifying and resolving ambivalence. DESIGN: A cluster randomised controlled trial was conducted with analysis at level of claimant (registration ISRCTN45748422). SETTING: The study was conducted at a workers' compensation rehabilitation facility in Edmonton, Canada...
June 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28647545/workplace-interventions-to-improve-sitting-posture-a-systematic-review
#5
REVIEW
Paul Alan Swinton, Kay Cooper, Elizabeth Hancock
Evaluate the effectiveness of workplace interventions to improve sitting posture of workers that spend long periods of time seated at a visual display terminal. A systematic review of randomised controlled trials, non-randomised controlled trials and single-group intervention trials featuring workplace interventions with pre- and follow-up measurements of sitting posture was conducted (registered in PROSPERO, CRD#42015027648). Nine databases were searched for studies available between January 2005 and February 2016...
June 21, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28646945/primary-amyloidosis-of-the-bladder-a-mimicker-of-bladder-cancer
#6
Ryan Fitzpatrick, Nicholas R Paterson, Eric C Belanger, Arleigh McCurdy, James Watterson
Amyloidosis is a protein folding disorder characterized by the deposition of fibrillar proteins into solid organs or tissues. Primary localized amyloidosis of the bladder is very rare and can mimic bladder cancer in its presentation with hematuria, lower urinary tract symptoms or a mass on imaging. A case of localized amyloidosis of the bladder in a 48-year-old man with painless gross hematuria and evidence of bladder mass on ultrasound is presented. Amyloidosis is a rare but important non-malignant process of the bladder...
June 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28646715/understanding-the-prevalence-of-lifetime-abstinence-from-alcohol-an-ecological-study
#7
Charlotte Probst, Jakob Manthey, Jürgen Rehm
BACKGROUND: The level of alcohol consumption and related burden in a country are strongly impacted by the prevalence of abstinence from alcohol use. The objective of this study was to characterize the association of lifetime abstinence from alcohol use with economic wealth (as measured in the gross domestic product [GDP]) and Muslim religion on a country level. METHODS: An ecological study was performed using aggregate data of 183 countries for the year 2010. Lifetime abstinence among men and women was predicted using fractional response regression models with the natural logarithm of GDP-PPP (purchasing power parity) and the proportion of Muslim population as predictors...
June 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28646530/pirfenidone-reduces-subchondral-bone-loss-and-fibrosis-after-murine-knee-cartilage-injury
#8
Deva D Chan, Jun Li, Wei Luo, Dan N Predescu, Brian J Cole, Anna Plaas
Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1(-/-) ) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1(-/-) mice, and Pirfenidone was administered in food starting after 3 days...
June 23, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28646377/efficacy-of-an-education-course-delivered-to-community-health-workers-in-diabetes-control-a-randomized-clinical-trial
#9
Camila Furtado de Souza, Mériane Boeira Dalzochio, Alessandra Teixeira Netto Zucatti, Rosana De Nale, Marília Tavares de Almeida, Jorge Luiz Gross, Cristiane Bauermann Leitão
BACKGROUND: Community health workers are community members who provide education and care for patients for a broad range of health issues, including diabetes mellitus. However, few community health workers are trained for diabetes education and little is known about the effectiveness of their interventions. The aim of this study is to evaluate the effect of a diabetes education program delivered to community health workers in improving the metabolic control of patients with type 2 diabetes mellitus...
June 23, 2017: Endocrine
https://www.readbyqxmd.com/read/28646025/remodeling-of-repolarization-and-arrhythmia-susceptibility-in-a-myosin-binding-protein-c-knockout-mouse-model
#10
Amir Toib, Chen Zhang, Giulia Borghetti, Xiaoxiao Zhang, Markus Wallner, Yijun Yang, Constantine Troupes, Hajime Kubo, Thomas Sharp, Eric Feldsott, Remus M Berretta, Neil Zalavadia, Danielle Trappanese, Shavonn Harper, Polina Gross, Xiongwen Chen, Sadia Mohsin, Steven Houser
Hypertrophic cardiomyopathy (HCM) is one of the most common genetic cardiac diseases and amongst the leading causes of sudden cardiac death (SCD) in the young. The cellular mechanisms leading to SCD in HCM are not well known. Prolongation of the action potential duration (APD) is a common feature predisposing hypertrophied hearts to SCD. Previous studies have explored the roles of inward Na(+) and Ca(2+) in the development of HCM, but the role of repolarizing K(+) currents have not been defined. The objective of this study was to characterize the arrhythmogenic phenotype and cellular electrophysiological properties of mice with HCM, induced by Myosin Binding Protein C (MyBPC) Knockout (KO) and to test the hypothesis that remodeling of repolarizing K(+) currents cause APD prolongation in MyBPC KO myocytes...
June 23, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28645884/investigation-of-the-effects-of-lycium-barbarum-polysaccharides-against-cadmium-induced-damage-in-testis
#11
Maria Vittoria Varoni, Sergio Domenico Gadau, Valeria Pasciu, Elena Baralla, Elisa Serra, Domenico Palomba, Maria Piera Demontis
This study describes the effects of Lycium barbarum polysaccharides (LBP) on testicular damage induced by cadmium (Cd). Adult male rats were i.p. injected with CdCl2 (4mg/Kg, once) with or without LBP pretreatment (300mg/Kg orally, once a day, for 30days). Testis weight, morphological/histological structure and oxidative stress parameters were evaluated. Several adverse effects were observed after CdCl2 injection, with a significant decrease in body/testis weight ratio (P<0.05), gross morphological changes with hyperemia of the parenchyma, increased volume and alteration in the structure of the seminiferous tubules...
June 20, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28645657/gross-pathology-physiological-and-toxicological-responses-in-relation-to-metals-and-persistent-organic-pollutants-pops-burden-in-tilapia-species-from-ogun-river-nigeria
#12
Oju R Ibor, Aina O Adeogun, Azubuike V Chukwuka, Augustine Arukwe
We have investigated gross pathology, physiological (steroid precursors) and toxicological responses (oxidative stress and phase II biotransformation) in relation to tissue contaminant burden in Tilapia species along the entire length (320 km) of Ogun River, Nigeria. The Ogun River is the longest and largest river in Southwestern Nigeria located along heavily industrialized cities and receives complex mixtures of effluents. A total of 1074 tilapias were collected from three sampling points (Abeokuta, Isheri and Ikorodu) and from an upstream control point (Igboho) and evaluated for gross pathological changes, hepatic transcript levels for oxidative stress and phase II biotransformation responses...
June 8, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28645604/posterior-paramedian-approach-to-a-ventrally-located-spinal-meningioma
#13
Han Soo Chang
BACKGROUND: To approach a ventral spinal pathology, a lateral viewing angle is often required. However, lateral approaches to the spine are usually more technically demanding and require certain amount of surgical expertise. In this report, we describe a simple and easy technique to obtain the lateral viewing angle to the ventral spinal pathology. CASE DESCRIPTION: The technique is demonstrated in a ventrally located meningioma at C2 level. Axial magnetic resonance imaging (MRI) showed a square posterior shift of the spinal cord with little lateral space, which necessitated a more lateral viewing angle than the conventional posterior approach...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28645194/predictors-of-treatment-response-and-survival-outcomes-in-meningioma-recurrence-with-atypical-or-anaplastic-histology
#14
Muhammad O Chohan, Christopher T Ryan, Ranjodh Singh, Ryan M Lanning, Anne S Reiner, Marc K Rosenblum, Viviane Tabar, Philip H Gutin
BACKGROUND: Recurrence rates for atypical and anaplastic meningiomas range between 9% and 50% after gross total resection and between 36% and 83% after subtotal resection. Optimal treatment of recurrent meningiomas exhibiting atypical/anaplastic histology is complicated because they are often refractory to both surgery and radiation. OBJECTIVE: To evaluate clinical determinants of recurrence and treatment-specific outcomes in patients with recurrent meningiomas exhibiting atypical/anaplastic histology at our institution...
June 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28645046/a-paradigm-shift-for-socioeconomic-justice-and%C3%A2-health-from-focusing-on-inequalities-to%C3%A2-aiming%C3%A2-at-sustainable-equity
#15
Juan E Garay, David E Chiriboga
OBJECTIVES: To measure the 'best possible health for all', incorporating sustainability, and to establish the magnitude of global health inequity. STUDY DESIGN: Observational, retrospective. METHODS: We identified countries with three criteria: (1) a healthy population-life expectancy above world average; (2) living conditions feasible to replicate worldwide-per-capita gross domestic product (GDP-pc) below the world average; and (3) sustainability-per-capita carbon dioxide emissions lower than the planetary pollution boundary...
June 20, 2017: Public Health
https://www.readbyqxmd.com/read/28644922/hands-support-and-postural-oscillation-during-sit-to-stand-movement-in-children-with-cerebral-palsy-and-typical-children
#16
Silvia Leticia Pavão, Nelci Adriana Cicuto Ferreira Rocha
The authors aimed to compare the weight bearing on hands during sit-to-stand (STS) movement in children with cerebral palsy (CP) and typical children (TC), verify its effect on postural oscillation, and analyze the relationship between weight bearing on hands and postural oscillation. Twenty children with CP (Gross Motor Function Classification System levels I and II) and 35 TC performed STS with and without anterior hands support. Mann-Whitney test compared weight bearing between groups. Wilcoxon test investigated differences in postural oscillation between the conditions with and without anterior hand support for both groups...
June 23, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28644821/zirconium-oxocluster-polymer-hybrid-nanoparticles-prepared-by-photoactivated-miniemulsion-copolymerization
#17
Cesare Benedetti, Paraskevi Flouda, Alice Antonello, Christine Rosenauer, Francisco F Perez-Pla, Katharina Landfester, Silvia Gross, Rafael Munoz-Espi
Photoactivated free radical miniemulsion copolymerization of methyl methacrylate (MMA) and the zirconium oxocluster Zr4O2(methacrylate)12 is used as an effective and fast preparation method of polymer/inorganic hybrid nanoparticles. The oxoclusters, covalently anchored to the polymer network, act as metal-organic cross-linkers, thus improving the thermomechanical properties of the resulting hybrid nanoparticles. Benzoin carbonyl organic compounds were used as photoinitiators. The obtained materials are compared in terms of cross-linking, effectiveness of cluster incorporation, and size distribution with the analogous nanoparticles produced by using conventional thermally-induced free radical miniemulsion copolymerization...
June 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28644716/the-effects-of-acute-carbohydrate-and-caffeine-feeding-strategies-on-cycling-efficiency
#18
Matthew Cole, James G Hopker, Jonathan D Wiles, Damian A Coleman
To assess the effect of carbohydrate and caffeine on gross efficiency (GE), 14 cyclists (V̇O2max 57.6 ± 6.3 ml.kg(-1.)min(-1)) completed 4 × 2-hour tests at a submaximal exercise intensity (60% Maximal Minute Power). Using a randomized, counter-balanced crossover design, participants consumed a standardised diet in the 3-days preceding each test and subsequently ingested either caffeine (CAF), carbohydrate (CHO), caffeine+carbohydrate (CAF+CHO) or water (W) during exercise whilst GE and plasma glucose were assessed at regular intervals (~30 mins)...
June 23, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28644345/yield-of-endoscopy-in-pediatric-gastroparesis
#19
Tara A Altepeter, Stephen Shaffer
OBJECTIVES: The aim of the study was to quantify the diagnostic yield of upper endoscopy in children with gastroparesis and to develop a clinical model for gastroparesis using common symptoms and screening blood tests. METHODS: We retrospectively reviewed charts of 196 patients of age 4 to 18 years evaluated for gastroparesis between 2009 and 2013. All patients completed a standard solid-phase gastric emptying scan and upper endoscopy within a 12-month period. We analyzed gross and histologic endoscopy findings...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28644242/effects-of-participation-in-sports-programs-on-walking-ability-and-endurance-over-time-in-children-with-cerebral-palsy
#20
Sandy A Ross, Morgan Yount, Sara Ankarstad, Samantha Bock, Britta Orso, Kimberly Perry, Jennifer Miros, Janice E Brunstrom-Hernandez
OBJECTIVE: Children with cerebral palsy may benefit from maintaining a high level of physical fitness similar to typically developing children especially in terms of long-term physical performance, although in practice this is often difficult. The purpose of this study was to determine the effect of participation in sports programs on walking ability and endurance over time. DESIGN: A retrospective cohort study included participants with cerebral palsy, aged 6 to 20 yrs, who attended a summer sports program from 2004 to 2012...
June 21, 2017: American Journal of Physical Medicine & Rehabilitation
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