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Paul R Hunter, Annette Prüss-Ustün
BACKGROUND: Although widely accepted as being one of the most important public health advances of the past hundred years, the contribution that improving sanitation coverage can make to child health is still unclear, especially since the publication of two large studies of sanitation in India which found no effect on child morbidity. We hypothesis that the value of sanitation does not come directly from use of improved sanitation but from improving community coverage. If this is so we further hypothesise that the relationship between sanitation coverage and child health will be non-linear and that most of any health improvement will accrue as sanitation becomes universal...
2016: PloS One
Harman Khatkar, Harry Hothi, Danielle de Villiers, Christian Lausmann, Daniel Kendoff, Thorsten Gehrke, John Skinner, Alister Hart
PURPOSE: Ceramic coatings have been used in metal-on-polyethylene (MOP) hips to reduce the risk of wear and also infection; the clinical efficacy of this remains unclear. This retrieval study sought to better understand the performance of coated bearing surfaces. METHODS: Forty-three coated MOP components were analysed post-retrieval for evidence of coating loss and gross polyethylene wear. Coating loss was graded using a visual semi-quantitative protocol. Evidence of gross polyethylene wear was determined by radiographic analysis and visual inspection of the retrieved implants...
October 25, 2016: International Orthopaedics
Zhale Rajavi, Ali Lashgari, Hamideh Sabbaghi, Narges Behradfar, Mehdi Yaseri
PURPOSE: To determine the incidence and related risk factors of reoperation among patients with infantile exotropia who were operated on at Imam Hossein Medical Center, Tehran, Iran, from 2001 to 2015. METHODS: In this study, 82 children (55 girls and 27 boys) with infantile exotropia were divided into two groups 3 months after their first operation: children with horizontal deviation of 10 prism diopters (PD) or less (n = 64; success group) and those with horizontal deviation greater than 10 PD (n = 18; failure group)...
October 25, 2016: Journal of Pediatric Ophthalmology and Strabismus
Vivek S Chawathe, Anil K Gaur, Badrinath D Athani, Shefali Gupta
A 14-year-old boy reported with congenital deformity of the left lower limb, with gross shortening, hip and knee flexion deformities, ankle with equinus deformity, and polydactyly of the left foot. Radiologic examination showed proximal femoral focal deficiency, double fibula, and duplication of the tarsal bones, and a diagnosis of 'proximal femoral focal deficiency associated with fibular duplication and diplopodia with complete agenesis of tibia' was made. Such association of deformities is very rare and poses difficulties in rehabilitation of the case...
October 25, 2016: Journal of Pediatric Orthopedics. Part B
Moses Abiala, John Olayiwola, Oluwatoyin Babatunde, Olapeju Aiyelaagbe, Sunday Akinyemi
BACKGROUND: Plant extracts were evaluated on poultry bacteria known to be threatening public health. This is to develop better bio-therapeutic agents from plant origin. METHODS: Bacteria were isolated from water, feed, crop, gizzard and faeces of layer chicken. Isolates of interest (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa and Klebsiella oxytoca) were subjected to antibiotic susceptibility test. Resistant strains were further evaluated against different plant extracts in comparison to Meropenem (control) using agar diffusion method...
October 26, 2016: BMC Complementary and Alternative Medicine
Eugénie Riesenkampff, Wietske Luining, Mike Seed, Paweena Chungsomprasong, Cedric Manlhiot, Bernadette Elders, Brian W McCrindle, Shi-Joon Yoo, Lars Grosse-Wortmann
BACKGROUND: Unfavorable left ventricular (LV) remodelling may be associated with adverse outcomes after Tetralogy of Fallot (TOF) repair. We sought to assess T1 cardiovascular magnetic resonance (CMR) markers of diffuse LV myocardial fibrosis in children after TOF repair, and associated factors. METHODS: In this prospective, cross-sectional study, native (=non-contrast) T1 times and extracellular volume fraction (ECV) were quantified in the LV myocardium using CMR...
October 26, 2016: Journal of Cardiovascular Magnetic Resonance
Gerald D Dodd, Anthony C Lanctot, Kimberly E Lind
Purpose To investigate the effect of change in portal vein flow rates on the size and shape of ablations created by a bipolar radiofrequency (RF) ablation device. Materials and Methods This study was exempt from institutional animal care and use committee review. An in vitro bovine liver model perfused with autologous blood via the portal vein at three flow rates (60, 80, 100 mL/min per 100 g of liver) was used. Four ablations, two bipolar and two monopolar (control probe), were made in each of five livers perfused at each flow rate...
October 19, 2016: Radiology
Young Bin Ji, Seung Jae Oh, Seok-Gu Kang, Jung Heo, Sang-Hoon Kim, Yuna Choi, Seungri Song, Hye Young Son, Se Hoon Kim, Ji Hyun Lee, Seung Joo Haam, Yong Min Huh, Jong Hee Chang, Chulmin Joo, Jin-Suck Suh
Gross total resection (GTR) of glioma is critical for improving the survival rate of glioma patients. One of the greatest challenges for achieving GTR is the difficulty in discriminating low grade tumor or peritumor regions that have an intact blood brain barrier (BBB) from normal brain tissues and delineating glioma margins during surgery. Here we present a highly sensitive, label-free terahertz reflectometry imaging (TRI) that overcomes current key limitations for intraoperative detection of World Health Organization (WHO) grade II (low grade), and grade III and IV (high grade) gliomas...
October 26, 2016: Scientific Reports
Nicholas F Brown, Thomas Carter, Paul Mulholland
Pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor. Anaplastic features are found in 20-30% of cases of PXA and are associated with poor outcomes. Typical treatment is with gross total resection, followed by radiation therapy and cytotoxic chemotherapy at relapse. BRAFV600 mutations have been identified in 38-60% of patients with PXA. Several case reports and small case series have identified clinical benefit with BRAF inhibition in patients with BRAFV600-mutated PXA. We report the second published case of successful treatment with the BRAF inhibitor dabrafenib in a female patient with relapsed anaplastic PXA with a BRAFV600 mutation, and the first published case of dabrafinib treatment following intolerance to vemurafenib...
October 26, 2016: CNS Oncology
Rimal Hanif Dossani, Hesam Akbarian-Tefaghi, Lori Lemonnier, Vikas Mehta, Jamie A Jacobsohn, Bharat Guthikonda
Mucoepidermoid carcinoma (MEC) is one of the most common malignant tumors of both major and minor salivary glands. Although there are reports of parotid MEC tumors extending intracranially via the facial nerve, intracranial extension from MEC originating from minor salivary glands in the palate has not previously been reported. This report presents a case of MEC arising from the minor salivary glands of the palate and extending into the middle fossa via the foramen rotundum with perineural invasion of the maxillary division of the trigeminal nerve...
October 2016: Journal of Neurological Surgery Reports
Benjamin Mason Meier, Averi Chakrabarti
The Kingdom of Bhutan is seeking to progressively realize the human right to health without addressing the cross-cutting human rights principles essential to a rights-based approach to health. Through a landscape analysis of the Bhutanese health system, documentary review of Bhutanese reporting to the United Nations human rights system, and semi-structured interviews with health policymakers in Bhutan, this study examines the normative foundations of Bhutan's focus on "a more meaningful purpose for development than just mere material satisfaction...
June 2016: Health and Human Rights
Cullen L Myers, Franco K K Li, Byoung-Mo Koo, Omar M El-Halfawy, Shawn French, Carol A Gross, Natalie C J Strynadka, Eric D Brown
The cell wall of most Gram-positive bacteria contains equal amounts of peptidoglycan and the phosphate-rich glycopolymer wall teichoic acid (WTA). During phosphate-limited growth of the Gram-positive model organism Bacillus subtilis 168, WTA is lost from the cell wall in a response mediated by the PhoPR two component system, which regulates genes involved in phosphate conservation and acquisition. It has been thought that WTA provides a phosphate source to sustain growth during starvation conditions, however, WTA degradative pathways have not been described for this, or any condition of bacterial growth...
October 25, 2016: Journal of Biological Chemistry
James C Fredenburgh, Peter L Gross, Jeffrey I Weitz
Despite the introduction of direct oral anticoagulants (DOACs), the search for more effective and safer antithrombotic strategies continues. Better understanding of the pathogenesis of thrombosis has fostered two new approaches to achieving this goal. First, evidence that thrombin may be as important as platelets to thrombosis at sites of arterial injury and that platelets contribute to venous thrombosis has prompted trials comparing anticoagulants with aspirin for secondary prevention in arterial thrombosis and aspirin with anticoagulants for primary and secondary prevention of venous thrombosis...
October 25, 2016: Blood
Lannah L Lua, Tiare Evans, Nadia Gomez
When gross hematuria occurs after a successful vaginal birth after cesarean section, bladder injury should be suspected. We present the case of a postpartum patient who had progressively worsening abdominal pain a few hours after delivery and was found to have a simultaneous bladder and uterine rupture. The case highlights a laparoscopic approach to repairing both defects in the immediate postpartum period.
October 22, 2016: Journal of Minimally Invasive Gynecology
Cristina Paules, Victoria Pueyo, Elena Martí, Susana Vilchez, Irina Burd, Pilar Calvo, Daniel Oros
BACKGROUND: Threatened preterm labor is a leading cause of hospital admission during pregnancy. Patients presenting with an episode of threatened preterm labor who deliver at term are considered to have false preterm labor. However, threatened preterm labor has been proposed as a pathological insult that is not always sufficient to induce irreversible spontaneous preterm birth but that could alter the normal course of pregnancy. OBJECTIVE: The aim of this study was to evaluate threatened preterm labor during pregnancy as a risk factor of neurodevelopmental deficits of children at 2 years of age...
October 22, 2016: American Journal of Obstetrics and Gynecology
I Biasato, M Tursi, S Zanet, E Longato, M T Capucchio
A 7-year-old male castrated domestic short-haired cat suddenly died. Gross examination revealed severe right-sided haemothorax with blood clots, four adult filarial nematodes in the blood clots and the caudal vena cava and haemorrhage dissecting into the tunica media of the right pulmonary artery. Histopathological investigation showed fibrosis of the tunica intima and disorganization/fragmentation of the elastic fibres accompanied by fibrous tissue deposition in the tunica media of both branches of pulmonary artery...
October 22, 2016: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
T Doshi, C Wilson, C Paterson, C Lamb, A James, K MacKenzie, J Soraghan, L Petropoulakis, G Di Caterina, D Grose
AIMS: To carry out statistical validation of a newly developed magnetic resonance imaging (MRI) auto-contouring software tool for gross tumour volume (GTV) delineation in head and neck tumours to assist in radiotherapy planning. MATERIALS AND METHODS: Axial MRI baseline scans were obtained for 10 oropharyngeal and laryngeal cancer patients. GTV was present on 102 axial slices and auto-contoured using the modified fuzzy c-means clustering integrated with the level set method (FCLSM)...
October 22, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
Kamil Krawczynski, Takuya Mishima, Xin Huang, Yoel Sadovsky
MicroRNA-210 (miR-210) has been implicated in homeostatic adaptation during hypoxia. We hypothesized that miR-210 deficiency impacts feto-placental growth. As expected, mir-210 knockout (ko) mice exhibited markedly reduced placental miR-210 expression, compared to wild-type (wt) mice. Mating of mir-210 heterozygotes resulted in near Mendelian progeny distribution, with insignificant differences between wt and ko animals with regard to embryo or placental weight and gross morphology. Intriguingly, exposure of mice to non-severe hypoxia (O2 = 12%) between E11...
November 2016: Placenta
Julie Ouellet-Pelletier, Chantal Guimont, Marie Gauthier, Jocelyn Gravel
OBJECTIVES: The purpose of this study was to assess adverse events associated with diagnostic urethral catheterization (UC) in young children and to determine their impact on the patient and their family. METHODS: This was a prospective cohort study conducted in the emergency department of a tertiary-care pediatric hospital. All 3- to 24-month-old children with fever who had a diagnostic UC were eligible. Parents who consented to participate were contacted by phone within 7 to 10 days after the UC to answer a standardized questionnaire inquiring about complications...
November 2016: CJEM
R Walker, T Carvalho-Pereira, S Serrano, G Pedra, K Hacker, J Taylor, A Minter, A Pertile, A Panti-May, M Carvalho, F N Souza, N Nery, G Rodrigues, T Bahiense, M G Reis, A I Ko, J E Childs, M Begon, F Costa
Urban slum environments in the tropics are conducive to the proliferation and the spread of rodent-borne zoonotic pathogens to humans. Calodium hepaticum (Brancroft, 1893) is a zoonotic nematode known to infect a variety of mammalian hosts, including humans. Norway rats (Rattus norvegicus) are considered the most important mammalian host of C. hepaticum and are therefore a potentially useful species to inform estimates of the risk to humans living in urban slum environments. There is a lack of studies systematically evaluating the role of demographic and environmental factors that influence both carriage and intensity of infection of C...
October 26, 2016: Epidemiology and Infection
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