keyword
https://read.qxmd.com/read/38490314/sirtuin-1-in-osteoarthritis-perspectives-on-regulating-glucose-metabolism
#1
REVIEW
Zhihao Liao, Xuepei Cai, Yifan Zheng, Jiayu Lin, Xia Yang, Weiyin Lin, Ying Zhang, Xin He, Chufeng Liu
Osteoarthritis (OA) is a degenerative disease characterised by articular cartilage destruction, and its complex aetiology contributes to suboptimal clinical treatment outcomes. A close association exists between glucose metabolism dysregulation and OA pathogenesis. Owing to the unique environment of low oxygen and glucose concentrations, chondrocytes rely heavily on their glycolytic capacity, exhibiting distinct spatiotemporal differences. However, under pathological stimulation, chondrocytes undergo excessive glycolytic activity while mitochondrial respiration and other branches of glucose metabolism are compromised...
March 13, 2024: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/38397799/piceid-octanoate-protects-retinal-cells-against-oxidative-damage-by-regulating-the-sirtuin-1-poly-adp-ribose-polymerase-1-axis-in-vitro-and-in-rd10-mice
#2
JOURNAL ARTICLE
Seyed Mohamadmehdi Moshtaghion, Estefanía Caballano-Infantes, Álvaro Plaza Reyes, Lourdes Valdés-Sánchez, Patricia Gallego Fernández, Berta de la Cerda, Maurizio S Riga, Manuel Álvarez-Dolado, Pablo Peñalver, Juan C Morales, Francisco J Díaz-Corrales
Retinitis pigmentosa is a common cause of inherited blindness in adults, which in many cases is associated with an increase in the formation of reactive oxygen species (ROS) that induces DNA damage, triggering Poly-ADP-Ribose Polymerase 1 (PARP1) activation and leading to parthanatos-mediated cell death. Previous studies have shown that resveratrol (RSV) is a promising molecule that can mitigate PARP1 overactivity, but its low bioavailability is a limitation for medical use. This study examined the impact of a synthesized new acylated RSV prodrug, piceid octanoate (PIC-OCT), in the 661W cell line against H2 O2 oxidative stress and in rd10 mice...
February 4, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38283227/sirtuin-1-activating-derivatives-belonging-to-the-anilinopyridine-class-displaying-in-vivo-cardioprotective-activities
#3
JOURNAL ARTICLE
Giulia Bononi, Valentina Citi, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo
Sirtuin 1 (SIRT1) is an enzyme that relies on NAD+ cofactor and functions as a deacetylase. It has been associated with various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases. Recent studies have shown that compounds that activate SIRT1 exhibit protective effects on the heart. Consequently, targeting SIRT1 has emerged as a viable approach to treat cardiovascular diseases, leading to the identification of several SIRT1 activators derived from natural or synthetic sources...
January 25, 2024: RSC medicinal chemistry
https://read.qxmd.com/read/38070792/sirt1-srebps-mediated-regulation-of-lipid-metabolism
#4
REVIEW
Shan Shen, Mingyang Shen, Lirun Kuang, Keyu Yang, Shiran Wu, Xinde Liu, Yuting Wang, Yong Wang
Sirtuins, also called silent information regulator 2, are enzymes that rely on nicotinamide adenine dinucleotide (NAD+) to function as histone deacetylases. Further investigation is warranted to explore the advantageous impacts of Sirtuin 1 (SIRT1), a constituent of the sirtuin group, on lipid metabolism, in addition to its well-researched involvement in extending lifespan. The regulation of gene expression has been extensively linked to SIRT1. Sterol regulatory element-binding protein (SREBP) is a substrate of SIRT1 that has attracted significant interest due to its role in multiple cellular processes including cell cycle regulation, DNA damage repair, and metabolic functions...
December 7, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37948437/senescence-targeted-and-nad-dependent-sirt1-activated-nanoplatform-to-counteract-stem-cell-senescence-for-promoting-aged-bone-regeneration
#5
JOURNAL ARTICLE
Ying Wang, Fangru Xie, Zirui He, Lingbin Che, Xi Chen, Yuan Yuan, Changsheng Liu
Age-related bone defects are a leading cause of disability and mortality in elderly individuals, and targeted therapy to delay the senescence of bone marrow-derived mesenchymal stem cells (MSCs) has emerged as a promising strategy to rejuvenate bone regeneration in aged scenarios. More specifically, activating the nicotinamide adenine dinucleotide (NAD+ )-dependent sirtuin 1 (SIRT1) pathway is demonstrated to effectively counteract MSC senescence and thus promote osteogenesis. Herein, based on an inventively identified senescent MSC-specific surface marker Kremen1, a senescence-targeted and NAD+ dependent SIRT1 activated nanoplatform is fabricated with a dual delivery of resveratrol (RSV) (SIRT1 promoter) and nicotinamide riboside (NR, NAD+ precursor)...
November 10, 2023: Small
https://read.qxmd.com/read/37388281/the-impacts-of-resveratrol-on-the-retinal-degeneration-in-a-rat-model-of-retinitis-pigmentosa-induced-by-alkylation-an-in-vivo-study
#6
JOURNAL ARTICLE
Weiming Yan, Yan Sun, Yutong Wang, Wangjiao Liang, Yuxin Xia, Weihua Yan, Meizhu Chen, Tao Chen, Dongliang Li
Upregulation of Sirtuin Type 1 (SIRT1), a nicotinamide adeninedinucleotide (NAD+ )-dependent deacetylase, has been proved to protect against ample ocular diseases, while its effect on retinitis pigmentosa (RP) has not been illustrated. The study was aimed to explore the impacts of resveratrol (RSV), a SIRT1 activator, on the photoreceptor degeneration in a rat model of RP induced by N-methyl-N-nitrosourea (MNU), an alkylation. The rats were induced RP phenotypes via the intraperitoneal injection of MNU. The electroretinogram was conducted and revealed that RSV could not prevent the decline of retinal function in the RP rats...
2023: Animal Cells and Systems
https://read.qxmd.com/read/37261640/sirt1-slows-the-progression-of-lupus-nephritis-by-regulating-the%C3%A2-nlrp3-inflammasome-through-ros-trpm2-ca-2-channel
#7
JOURNAL ARTICLE
Jihua Tian, Taiping Huang, Jingshu Chen, Jing Wang, Sijia Chang, Huanyu Xu, Xiaoshuang Zhou, Jia Yang, Yuan Xue, Tingting Zhang, Weiping Fan, Yanhong Wang
Systemic lupus erythematosus (SLE) is a chronic multisystem inflammatory disease associated with autoantibody formation. Lupus nephritis (LN) is one of the most severe organ manifestations of SLE. The inflammatory response is a key factor in kidney injury, and the NLRP3 inflammasome is frequently associated with the pathogenesis of LN. Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide (NAD +)-dependent histone deacetylase, is a promising therapeutic target for preventing renal injury. However, the mechanism of SIRT1 in LN remains unclear...
June 1, 2023: Clinical and Experimental Medicine
https://read.qxmd.com/read/37256428/resveratrol-attenuates-chronic-unpredictable-mild-stress-induced-alterations-in-the-sirt1-pgc1%C3%AE-sirt3-pathway-and-associated-mitochondrial-dysfunction-in-mice
#8
JOURNAL ARTICLE
Sidra Tabassum, Afzal Misrani, Hui-Xian Huang, Zai-Yong Zhang, Qiao-Wei Li, Cheng Long
Environmental challenges, specifically chronic stress, have long been associated with neuropsychiatric disorders, including anxiety and depression. Sirtuin-1 (SIRT1) is a NAD+ -dependent deacetylase that is widely distributed in the cortex and is involved in stress responses and neuropsychiatric disorders. Nevertheless, how chronic stress modulates the SIRT1 pathway and associated signaling remains unclear. In this study, we first explored the impact of chronic unpredictable mild stress (CUMS) on the SIRT1/PGC1α/SIRT3 pathway, on GABAergic mechanisms, and on mitophagy, autophagy and apoptosis in mice...
May 31, 2023: Molecular Neurobiology
https://read.qxmd.com/read/37169475/resveratrol-a-sirt1-activator-attenuates-aging-associated-alterations-in-skeletal-muscle-and-heart-in-mice
#9
JOURNAL ARTICLE
Ryusuke Hosoda, Ryuta Nakashima, Masaki Yano, Naotoshi Iwahara, Seidai Asakura, Iyori Nojima, Yukika Saga, Risa Kunimoto, Yoshiyuki Horio, Atsushi Kuno
Aging is associated with impairment of multiple organs, including skeletal muscle and heart. In this study, we investigated whether resveratrol, an activator of an NAD+ -dependent protein deacetylase Sirtuin-1 (SIRT1), attenuates age-related sarcopenia and cardiomyocyte hypertrophy in mice. Treatment of mice with resveratrol (0.4 g/kg diet) from 28 weeks of age for 32 weeks prevented aging-associated shortening of rotarod riding time. In the tibialis anterior (TA) muscle, histogram analysis showed that the atrophic muscle was increased in 60-week-old (wo) mice compared with 20-wo mice, which was attenuated by resveratrol...
June 2023: Journal of Pharmacological Sciences
https://read.qxmd.com/read/37116286/sirtuins-resveratrol-and-the-intertwining-cellular-pathways-connecting-them
#10
REVIEW
Anca Ungurianu, Anca Zanfirescu, Denisa Margină
Sirtuins are a family of NAD+ -dependent deacylases with numerous physiological and pathological implications, which lately became an attractive therapeutic target. Sirtuin-activating compounds (STACs) could be useful in disease prevention and treatment. Despite its bioavailability issues, resveratrol exerts a myriad of beneficial effects, known as the "resveratrol paradox". Modulation of sirtuins' expression and activity may, in fact, underlie many of resveratrol revered actions; however, the cellular pathways affected by modulating the activity of each sirtuin isoform, in different physio-pathological conditions, are not fully known...
July 2023: Ageing Research Reviews
https://read.qxmd.com/read/37105251/a-pharmacological-review-on-sirt-1-and-sirt-2-proteins-activators-and-inhibitors-call-for-further-research
#11
REVIEW
Mukesh Nandave, Rituparna Acharjee, Kinkini Bhaduri, Jyoti Upadhyay, Gnana Prasoona Rupanagunta, Mohd Nazam Ansari
Sirtuins or Sir (Silent information regulator) are NAD+ -dependent enzymes playing an important part in the pathogenesis and treatment of various disorders. They have ubiquitously expressed protein deacetylases. They are implicated in several cellular activities like DNA repair, cellular metabolism, mitochondrial function, and inflammation. Deletion of sirtuin protein, SIRT1 in the organs like brain, heart, liver and pancreas can cause inflammation and increases the level of free radical ions causing oxidative stress...
April 25, 2023: International Journal of Biological Macromolecules
https://read.qxmd.com/read/36881661/divergent-roles-of-sirtuin-1-in-human-granulosa-lutein-cells-similarities-to-hcg
#12
JOURNAL ARTICLE
Rina Meidan, Magdalena Szymanska
Sirtuin 1 (SIRT1) is an NAD+ dependent deacetylase that modifies gene expression through histone deacetylation. It also deacetylates non-histone substrates, e.g. tumor suppressor p53, NOS3, HIF1A, NFKB, FOXO3a, PGC-1α, and PPARγ. Consequently, it regulates a wide range of physiological functions including cell cycle control, energy expenditure, oxidative stress response, apoptosis, and aging. SIRT1 is expressed in ovarian granulosa cells (GCs) of various species including humans at different stages of the reproductive cycle...
March 6, 2023: Biology of Reproduction
https://read.qxmd.com/read/36597461/shedding-light-on-structure-function-and-regulation-of-human-sirtuins-a-comprehensive-review
#13
REVIEW
Abhishek Sharma, Pragati Mahur, Jayaraman Muthukumaran, Amit Kumar Singh, Monika Jain
Sirtuins play an important role in signalling pathways associated with various metabolic regulations. They possess mono-ADP-ribosyltransferase or deacylase activity like demalonylase, deacetylase, depalmitoylase, demyristoylase and desuccinylase activity. Sirtuins are histone deacetylases which depends upon nicotinamide adenine dinucleotide (NAD) that deacetylate lysine residues. There are a total of seven human sirtuins that have been identified namely, SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6 and SIRT7. The subcellular location of mammalian sirtuins, SIRT1, SIRT6, and SIRT7 are in the nucleus; SIRT3, SIRT4, and SIRT5 are in mitochondria, and SIRT2 is in cytoplasm...
January 2023: 3 Biotech
https://read.qxmd.com/read/36522127/nutraceutical-activation-of-sirt1-a-review
#14
REVIEW
James J DiNicolantonio, Mark F McCarty, James H O'Keefe
The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several complementary effects on cellular function that are favourable to healthspan; it is often thought of as an 'anti-aging' enzyme. Practical measures which might boost Sirt1 activity are therefore of considerable interest. A number of nutraceuticals have potential in this regard. Nutraceuticals reported to enhance Sirt1 synthesis or protein expression include ferulic acid, tetrahydrocurcumin, urolithin A, melatonin, astaxanthin, carnosic acid and neochlorogenic acid...
December 2022: Open Heart
https://read.qxmd.com/read/36235072/sirtuin-1-activating-compounds-discovery-of-a-class-of-thiazole-based-derivatives
#15
JOURNAL ARTICLE
Giulia Bononi, Valentina Citi, Margherita Lapillo, Alma Martelli, Giulio Poli, Tiziano Tuccinardi, Carlotta Granchi, Lara Testai, Vincenzo Calderone, Filippo Minutolo
Sirtuin 1 (SIRT1) is a NAD+ -dependent deacetylase implicated in various biological and pathological processes, including cancer, diabetes, and cardiovascular diseases. In recent years, SIRT1-activating compounds have been demonstrated to exert cardioprotective effects. Therefore, this enzyme has become a feasible target to treat cardiovascular diseases, and many SIRT1 activators, of a natural or synthetic origin, have been identified. In the present work, we developed thiazole-based SIRT1 activators, which showed remarkably higher SIRT1 activation potencies compared with those of the reference compound resveratrol when tested in enzymatic assays...
October 3, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36230032/sirtfoods-new-concept-foods-functions-and-mechanisms
#16
REVIEW
Otobong Donald Akan, Dandan Qin, Tianyi Guo, Qinlu Lin, Feijun Luo
Sirtfood is a new concept food that compounds diets that can target sirtuins (SIRTs). SIRTs are nicotinamide adenine dinucleotide (NAD+ )-dependent deacylases and ADP-ribosyltransferases (enzymes). SIRTs are mediators of calorie restriction (CR) and their activation can achieve some effects similar to CR. SIRTs play essential roles in ameliorating obesity and age-related metabolic diseases. Food ingredients such as resveratrol, piceatannol, anthocyanidin, and quinine are potential modulators of SIRTs. SIRT modulators are involved in autophagy, apoptosis, aging, inflammation, and energy homeostasis...
September 21, 2022: Foods (Basel, Switzerland)
https://read.qxmd.com/read/36153473/research-progress-on-the-role-of-sirtuin-1-in-cerebral-ischemia
#17
REVIEW
Yijia Fangma, Haitong Wan, Chongyu Shao, Liang Jin, Yu He
A significant amount of evidence from the past few years has shown that Sirtuin 1 (SIRT1), a histone deacetylase dinucleotide of nicotinamide adenine dinucleotide (NAD+ ) is closely related to the cerebral ischemia. Several potential neuroprotective strategies like resveratrol, ischemia preconditioning, and caloric restriction exert their neuroprotection effects through SIRT1-related signaling pathway. However, the potential mechanisms and neuroprotection of SIRT1 in the process of cerebral ischemia injury development and recovery have not been systematically elaborated...
September 24, 2022: Cellular and Molecular Neurobiology
https://read.qxmd.com/read/35802632/short-term-resveratrol-treatment-restored-the-quality-of-oocytes-in-aging-mice
#18
JOURNAL ARTICLE
Naoki Okamoto, Yorino Sato, Yuta Kawagoe, Takahiko Shimizu, Kazuhiro Kawamura
The quality of oocytes declines by aging, resulting in their low competences for fertility. Here, resveratrol treatment showed increases in the rates of implantation and live offspring as well as decreases in the abortion rate as short as one week after treatment, although the number of ovulated oocytes and the rates of fertilization and blastocyst formation were not changed following resveratrol treatment. Resveratrol treatment did not cause abnormalities mouse estrous cycles and body weights. No abnormality was detected in both fetuses and placentas after 22 weeks of resveratrol treatment and the fetuses had normal fertility...
July 8, 2022: Aging
https://read.qxmd.com/read/35655601/the-effects-of-combined-resveratrol-and-high-intensity-interval-training-on-the-hippocampus-in-aged-male-rats-an-investigation-into-some-signaling-pathways-related-to-mitochondria
#19
JOURNAL ARTICLE
Maryam Amirazodi, Amin Mehrabi, Mohammad Amin Rajizadeh, Mohammad Abbas Bejeshk, Khadijeh Esmaeilpour, Farhad Daryanoosh, Abbasali Gaeini
Objectives: High-intensity interval training (HIIT) is a shape of interval training that provides ameliorated athletic capacity and has a good effect on health. Resveratrol is a natural polyphenol abundant in grapes and red wine and has been demonstrated to apply various useful health impacts on the body. This research aimed to evaluate the interactive effects of swimming HIIT and resveratrol consumption on SIRTs 3 & 4, NAD+/NADH, AMPK and SOD2 expression in aged rats. Materials and Methods: In total, forty-five old male albino rats (Wistar) with the age of twenty months were allocated into 5 groups randomly...
February 2022: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/35597887/preventive-effect-of-betaine-against-cognitive-impairments-in-amyloid-%C3%AE-peptide-injected-mice-through-sirtuin1-in-hippocampus
#20
JOURNAL ARTICLE
Daisuke Ibi, Sari Kondo, Ayano Ohmi, Yuya Kojima, Genki Nakasai, Rika Takaba, Masayuki Hiramatsu
In the pathophysiology of Alzheimer's disease, the deposition of amyloid β peptide (Aβ) is associated with oxidative stress, leading to cognitive impairment and neurodegeneration. We have already reported that betaine (glycine betaine), an osmolyte and methyl donor in cells, prevents the development of cognitive impairment in mice with intracerebroventricular injection of Aβ25-35 , an active fragment of Aβ, associated with oxidative stress in the hippocampus, but molecular mechanisms of betaine remain to be determined...
May 21, 2022: Neurochemical Research
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