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Melinda Vass, Ágnes Diószegi, Norbert Németh, Viktória Sógor, Sándor Baráth, Eszter Szalai, László Módis, Soltész Pál
Rheopheresis is an extracorporal selective double-filtration procedure. In the first part of the treatment the blood is passes through the plasma filter, which separates blood cells from the plasma. Then the plasma flow to a second filter called MONET (Membranefiltration Optimised Novel Extracorporal Treatment). The MONET filter retains high molecular weight proteins such LDL, Lp(a), fibrinogen, α2 macroglobulin, vWF and IgM. Hereby the whole blood and plasma viscosity decrease, improves microcirculation, and has a positive effect on lipid profile as well...
October 15, 2016: Clinical Hemorheology and Microcirculation
Faisal G Bakaeen, Eric E Roselli, Douglas R Johnston, Edward G Soltesz, Michael Z Tong, Lars G Svensson
No abstract text is available yet for this article.
September 28, 2016: Journal of Surgical Research
Kristian Soltesz, Christopher Sturk, Audrius Paskevicius, Qiuming Liao, Guangqi Qin, Trygve Sjoberg, Stig Steen
: The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model. METHODS: Dynamic modeling and system identification were based on in vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. RESULTS: The control system responded both predictably and consistently to external disturbances...
August 25, 2016: IEEE Transactions on Bio-medical Engineering
Ryu Komatsu, Natalya Makarova, Jing You, Daniel I Sessler, David G Anthony, Yusuke Kasuya, Edward G Soltesz, Alparslan Turan
OBJECTIVE: To compare incidence of atrial arrhythmia, duration of care, and major complications after cardiac surgery between patients who received etomidate and those who received other induction agents. DESIGN: Retrospective cohort study utilizing propensity score matching. SETTING: A single academic, tertiary care hospital. PARTICIPANTS: Eight thousand nine hundred seventy-eight patients undergoing coronary artery bypass grafting (CABG), valve, or combined valve/CABG surgery requiring cardiopulmonary bypass between January 2005 and December 2010...
April 28, 2016: Journal of Cardiothoracic and Vascular Anesthesia
Jay J Idrees, Farhang Yazdchi, Edward G Soltesz, Andrew M Vekstein, Christopher Rodriguez, Eric E Roselli
OBJECTIVE: Patients with complex aortic disease often require multistaged repairs with numerous anastomoses. Manual suturing can be time consuming. To reduce ischemic time, a circular stapling device has been used to facilitate prosthetic graft-to-graft anastomoses. Objectives are to describe this technique and assess outcomes. METHODS: From February 2009 to May 2014, 44 patients underwent complex aortic repair with a circular end-to-end anastomosis (EEA) stapler at Cleveland Clinic...
October 2016: Journal of Thoracic and Cardiovascular Surgery
Dávid Ágoston Kovács, László Asztalos, Renáta Laczik, Roland Fedor, László Szabó, Lajos Lőcsey, Pál Soltész
INTRODUCTION: Development of atherosclerosis is accelerated in kidney transplant patients. Impaired metabolic pathways have complex effect on the arterial wall which can be measured by non-invasive techniques. Only few data are available on the change of stiffness parameters in the postoperative course. Therefore, in this study the authors analysed the stiffness parameters of kidney transplant recipients during the perioperative period. AIM: Non-invasive clinical trial of the arterial functional parameters in the early postoperative period...
June 12, 2016: Orvosi Hetilap
Michael P Robich, Nicholas K Schiltz, Douglas R Johnston, Stephanie Mick, Amar Krishnaswamy, Rodrigo A Iglesias, Dustin Hang, Eric E Roselli, Edward G Soltesz
INTRODUCTION: The need for permanent pacemaker implantation (PCM) following surgical aortic valve replacement (SAVR) is uncommon but can lead to increased hospital resource utilization. Using nationwide data, we sought to (1) identify hospital, patient, and procedure-level risk factors for PCM after SAVR and (2) determine incremental resource utilization. METHODS: We identified 659,692 patients from the Nationwide Inpatient Sample database who underwent SAVR with or without coronary artery bypass grafting (CABG), mitral valvuloplasty (MVr), or mitral valve replacement (MVR) between 1998 and 2009...
August 2016: Journal of Cardiac Surgery
A Alexander, M Maroso, I Soltesz
When studying the pathological mechanisms of epilepsy, there are a seemingly endless number of approaches from the ultrastructural level-receptor expression by EM-to the behavioral level-comorbid depression in behaving animals. Epilepsy is characterized as a disorder of recurrent seizures, which are defined as "a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain" (Fisher et al., 2005). Such abnormal activity typically does not occur in a single isolated neuron; rather, it results from pathological activity in large groups-or circuits-of neurons...
2016: Progress in Brain Research
Michael Anapolski, Dimitrios Panayotopoulos, Ibrahim Alkatout, Stefan Soltesz, Sven Schiermeier, Günter Noé
BACKGROUND: Electromechanical power morcellation is an important tool of modern laparoscopy. Recent reports on the spread of previously undetected malignancy by power morcellation indicate the need for additional protective devices to reduce this risk. We conducted a study to obtain the first data concerning the safety of an endobag with three closable ports during morcellation and subsequent bag extraction under in vitro conditions, mimicking the settings in our operating theater. The second purpose of the study was to establish a minimal width of the skin incision necessary to safely extract the sealed bag after morcellation...
May 18, 2016: Surgical Endoscopy
Michael Anapolski, Dimitrios Panayotopoulos, Ibrahim Alkatout, Stefan Soltesz, Lieselotte Mettler, Sven Schiermeier, Wolfgang Hatzmann, Günter Noé
INTRODUCTION: Unprotected power morcellation can lead to a spread of previously undiagnosed malignancy. We present a new containment bag with two closable trocar insertion sites to reduce this risk. This pilot study was designed to assess the feasibility of this device under everyday conditions. MATERIAL AND METHODS: The containment bag was used in ten laparoscopic supracervical hysterectomies. We evaluated time requirement for bag insertion into the abdominal cavity and in-bag morcellation...
August 2016: Minimally Invasive Therapy & Allied Technologies: MITAT
Jay J Idrees, Eric E Roselli, Ashley M Lowry, Joshua M Reside, Hoda Javadikasgari, Daniel J Johnson, Edward G Soltesz, Douglas R Johnston, Gösta B Pettersson, Eugene H Blackstone, Joseph F Sabik, Lars G Svensson
BACKGROUND: Guidelines supporting the decision to replace the aorta in patients with chronic asymptomatic proximal aortic disease are limited by lack of data on operative risks and long-term effectiveness in relation to aortic size. Therefore, we assessed and compared outcomes of patients undergoing elective isolated proximal aortic replacement for this disease vs replacement during multicomponent operations. METHODS: From January 2006 to January 2011, 1,889 patients underwent proximal aortic replacement (isolated, 212; multicomponent, 1,677) for chronic asymptomatic ascending and arch pathology...
June 2016: Annals of Thoracic Surgery
Mattia Maroso, Gergely G Szabo, Hannah K Kim, Allyson Alexander, Anh D Bui, Sang-Hun Lee, Beat Lutz, Ivan Soltesz
The mechanisms underlying the effects of cannabinoids on cognitive processes are not understood. Here we show that cannabinoid type-1 receptors (CB1Rs) control hippocampal synaptic plasticity and spatial memory through the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels that underlie the h-current (Ih), a key regulator of dendritic excitability. The CB1R-HCN pathway, involving c-Jun-N-terminal kinases (JNKs), nitric oxide synthase, and intracellular cGMP, exerts a tonic enhancement of Ih selectively in pyramidal cells located in the superficial portion of the CA1 pyramidal cell layer, whereas it is absent from deep-layer cells...
March 2, 2016: Neuron
Allyson Alexander, Ivan Soltesz
No abstract text is available yet for this article.
April 2016: Nature Neuroscience
Stefan Soltesz, Christian Stark, Karl G Noé, Michael Anapolski, Thomas Mencke
PURPOSE: Positioning for surgery can restrict access to the patient's hand, thereby limiting assessment of the response at the adductor pollicis muscle to ulnar nerve stimulation. We evaluated a novel site to assess neuromuscular block by stimulating the accessory nerve and measuring the acceleromyographic response at the trapezius muscle. METHODS: In this prospective non-blinded observational study, we assessed neuromuscular transmission in anesthetized adult female patients undergoing elective laparoscopic gynecological surgery...
June 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Stefan Soltesz, Dorothee Meiger, Susanne Milles-Thieme, Guido Saxler, Stephan Ziegeler
PURPOSE: Many institutions perform peripheral femoral and/or sciatic nerve blocks for analgesia after total knee arthroplasty. The aim of the present investigation was to compare the analgesic effect of an intermittent sciatic block (boluses on demand only) with a continuous infusion. METHODS: One hundred and forty patients receiving a femoral and a sciatic nerve block (SNB) by catheter were assessed. The femoral catheter was infused continuously in both groups...
September 2016: International Orthopaedics
Anh D Bui, Allyson Alexander, Ivan Soltesz
The unpredictability and severity of seizures contribute to the debilitating nature of epilepsy. These factors also render the condition particularly challenging to treat, as an ideal treatment would need to detect and halt the pathological bursts of hyperactivity without disrupting normal brain activity. Optogenetic techniques offer promising tools to study and perhaps eventually treat this episodic disorder by controlling specific brain circuits in epileptic animals with great temporal precision. Here, we briefly review the current treatment options for patients with epilepsy...
December 23, 2015: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Alexander Kantorovich, Jodie M Fink, Michael A Militello, Seth R Bauer, Edward G Soltesz, Nader Moazami
Appropriate early anticoagulation after left ventricular assist device (LVAD) implantation has not been established with practices ranging from no anticoagulation to early heparinization. The goal of this study was to evaluate the efficacy and morbidity of three strategies before initiating oral anticoagulation therapy. This was a noninterventional, retrospective, matched historical control cohort study. The primary and secondary endpoints were thrombotic complications (TCs) and bleeding up to 30 days post-LVAD implantation...
March 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Cristian Rosu, Edward G Soltesz
The lack of an ideal prosthetic heart valve leaves surgeons and their patients with a difficult choice at the time of valve replacement surgery. Current guidelines mainly emphasize patient age, contraindications to anticoagulation, and patient desires in their recommendations for the type of prosthesis to implant. Aortic valve replacement is the most frequently performed valve replacement, and 5 articles in recent years have presented important data on outcomes with different prosthesis types. The findings suggest that in young patients, transvalvular prosthesis gradients have an effect on long-term bioprosthesis durability...
2015: Seminars in Thoracic and Cardiovascular Surgery
Caren Armstrong, Jessica Wang, Soo Yeun Lee, John Broderick, Marianne J Bezaire, Sang-Hun Lee, Ivan Soltesz
The medial entorhinal cortex layer II (MEClayerII ) is a brain region critical for spatial navigation and memory, and it also demonstrates a number of changes in patients with, and animal models of, temporal lobe epilepsy (TLE). Prior studies of GABAergic microcircuitry in MEClayerII revealed that cholecystokinin-containing basket cells (CCKBCs) select their targets on the basis of the long-range projection pattern of the postsynaptic principal cell. Specifically, CCKBCs largely avoid reelin-containing principal cells that form the perforant path to the ipsilateral dentate gyrus and preferentially innervate non-perforant path forming calbindin-containing principal cells...
June 2016: Hippocampus
Jay J Idrees, Nicholas K Schiltz, Douglas R Johnston, Stephanie Mick, Nicholas G Smedira, Joseph F Sabik, Eugene H Blackstone, Lars G Svensson, Edward G Soltesz
BACKGROUND: Postoperative stroke is a devastating complication after aortic valve replacement (AVR). Our objective was to use a large national database to identify the incidence of and risk factors for stroke after AVR, as well as to determine incremental mortality, resource use, and cost of stroke. METHODS: We identified 360,437 patients who underwent isolated surgical AVR between 1998 and 2011 from the National Inpatient Sample (NIH) database. Mean age was 66 ± 32 years...
March 2016: Annals of Thoracic Surgery
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