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https://www.readbyqxmd.com/read/29593317/ca1-pyramidal-cell-diversity-enabling-parallel-information-processing-in-the-hippocampus
#1
REVIEW
Ivan Soltesz, Attila Losonczy
Hippocampal network operations supporting spatial navigation and declarative memory are traditionally interpreted in a framework where each hippocampal area, such as the dentate gyrus, CA3, and CA1, consists of homogeneous populations of functionally equivalent principal neurons. However, heterogeneity within hippocampal principal cell populations, in particular within pyramidal cells at the main CA1 output node, is increasingly recognized and includes developmental, molecular, anatomical, and functional differences...
April 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29577764/-immunoadsorption-in-a-patient-with-dilated-cardiomyopathy-the-first-case-in-hungary
#2
Pál Soltész, Melinda Vass, Ágnes Diószegi, Ivetta Mányiné Siket, Ildikó Garai, Csaba Kun, Orsolya Bene, Attila Kertész, István Édes
Dilated cardiomyopathy is the main cause of heart transplantation. The etiology is unknown in almost half of the cases. Many cardiac specific antibodies have been identified till now which can cause decreased cardiac function, ventricular tachycardia or sudden heart death. The prognosis of DCM is poor despite the development of medical treatment. Immunoadsorption is hopeful since, with the removal of antibodies, cardiac function and NYHA class can improve and LVAD/heart transplantation-free survival can be prolonged...
April 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29540322/persistent-nature-of-alterations-in-cognition-and-neuronal-circuit-excitability-after-exposure-to-simulated-cosmic-radiation-in-mice
#3
Vipan K Parihar, Mattia Maroso, Amber Syage, Barrett D Allen, Maria C Angulo, Ivan Soltesz, Charles L Limoli
Of the many perils associated with deep space travel to Mars, neurocognitive complications associated with cosmic radiation exposure are of particular concern. Despite these realizations, whether and how realistic doses of cosmic radiation cause cognitive deficits and neuronal circuitry alterations several months after exposure remains unclear. In addition, even less is known about the temporal progression of cosmic radiation-induced changes transpiring over the duration of a time period commensurate with a flight to Mars...
July 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29449490/dentate-gyrus-mossy-cells-control-spontaneous-convulsive-seizures-and-spatial-memory
#4
Anh D Bui, Theresa M Nguyen, Charles Limouse, Hannah K Kim, Gergely G Szabo, Sylwia Felong, Mattia Maroso, Ivan Soltesz
Temporal lobe epilepsy (TLE) is characterized by debilitating, recurring seizures and an increased risk for cognitive deficits. Mossy cells (MCs) are key neurons in the hippocampal excitatory circuit, and the partial loss of MCs is a major hallmark of TLE. We investigated how MCs contribute to spontaneous ictal activity and to spatial contextual memory in a mouse model of TLE with hippocampal sclerosis, using a combination of optogenetic, electrophysiological, and behavioral approaches. In chronically epileptic mice, real-time optogenetic modulation of MCs during spontaneous hippocampal seizures controlled the progression of activity from an electrographic to convulsive seizure...
February 16, 2018: Science
https://www.readbyqxmd.com/read/29377282/impact-of-intraoperative-cytokine-adsorption-on-outcome-of-patients-undergoing-orthotopic-heart-transplantation-an-observational-study
#5
Endre Nemeth, Eniko Kovacs, Kristof Racz, Adam Soltesz, Szabolcs Szigeti, Nikolett Kiss, Gergely Csikos, Kinga B Koritsanszky, Viktor Berzsenyi, Gabor Trembickij, Szabolcs Fabry, Zoltan Prohaszka, Bela Merkely, Janos Gal
AIM: The aim of this study was to assess the influence of intraoperative cytokine adsorption on the perioperative vasoplegia, inflammatory response and outcome during orthotopic heart transplantation (OHT). METHODS: Eighty-four OHT patients were separated into the cytokine adsorption (CA)-treated group or controls. Vasopressor demand, inflammatory response described by procalcitonin and C-reactive protein, and postoperative outcome were assessed performing propensity score matching...
January 29, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29366029/rheopheresis-treatment-of-diabetic-foot-syndrome
#6
Agnes Dioszegi, Melinda Vass, Norbert Nemeth, Viktoria Sogor, Sador Barath, Miklos Kaplar, Pal Soltesz
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366028/study-of-microcirculatory-impairment-in-type-2-diabetic-patients-with-symptoms-of-peripherial-neuropathy
#7
Melinda Nanasy-Vass, Agnes Dioszegi, Anna Flasko, Ferenc Mechler, Miklos Kaplar, Pal Soltesz
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29365562/predictive-value-of-endothel-dysfunction-arterial-stiffness-and-carotid-intima-media-thickness-in-thrombotic-manifestations-of-primary-antiphospholipid-syndrome
#8
Katalin Veres, Agnes Dioszegi, Zsuzsa Bereczky, Beata Kovacs, Pal Soltesz
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353500/-doege-potter-syndrome-with-giant-malignant-solitary-fibrous-tumour-of-the-pleura
#9
József Kas, Attila Csekeő, Csaba Fehér, Attila Vágvölgyi, Gábor Grmela, Judit Varga, Zsolt Rozgonyi, Ibolya Soltész, János Fillinger, Zsuzsanna Pápai, Erika Lahm, Pál Vadász
Infrequent solitary fibrous tumours of the pleura are associated with hypoglycaemia only in a few percent of the cases; this condition is called Doege-Potter syndrome, named after its first descriptors. Our 63 years old male patient has previously undergone clinical treatment for intrathoracic fluid accumulation on the left side caused by a giant tumour-like mass in the lower left lobe detected by CT scan. In the course of further investigations performed due to increasing load-induced dyspnoea, lung core biopsy verified low grade sarcoma in the tumour...
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29335356/single-bursts-of-individual-granule-cells-functionally-rearrange-feedforward-inhibition
#10
Máté Neubrandt, Viktor János Oláh, János Brunner, Endre Levente Marosi, Ivan Soltesz, János Szabadics
The sparse single-spike activity of dentate gyrus granule cells (DG GCs) is punctuated by occasional brief bursts of 3-7 action potentials. It is well-known that such presynaptic bursts in individual mossy fibers (MFs; axons of granule cells) are often able to discharge postsynaptic CA3 pyramidal cells due to powerful short-term facilitation. However, what happens in the CA3 network after the passage of a brief MF burst, before the arrival of the next burst or solitary spike, is not understood. Because MFs innervate significantly more CA3 interneurons than pyramidal cells, we focused on unitary MF responses in identified interneurons in the seconds-long postburst period, using paired recordings in rat hippocampal slices...
February 14, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29317695/alterations-in-the-properties-of-the-cell-membrane-due-to-glycosphingolipid-accumulation-in-a-model-of-gaucher-disease
#11
Gyula Batta, Lilla Soltész, Tamás Kovács, Tamás Bozó, Zoltán Mészár, Miklós Kellermayer, János Szöllősi, Peter Nagy
Gaucher disease is a lysosomal storage disease characterized by the malfunction of glucocerebrosidase resulting in the accumulation of glucosylceramide and other sphingolipids in certain cells. Although the disease symptoms are usually attributed to the storage of undigested substrate in lysosomes, here we show that glycosphingolipids accumulating in the plasma membrane cause profound changes in the properties of the membrane. The fluidity of the sphingolipid-enriched membrane decreased accompanied by the enlargement of raft-like ordered membrane domains...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29273323/durability-of-aortic-valve-cusp-repair-with-and-without-annular-support
#12
Ahmad Zeeshan, Jay J Idrees, Douglas R Johnston, Jeevanantham Rajeswaran, Eric E Roselli, Edward G Soltesz, A Marc Gillinov, Brian Griffin, Richard Grimm, Donald F Hammer, Gösta B Pettersson, Eugene H Blackstone, Joseph F Sabik, Lars G Svensson
BACKGROUND: To determine the value of aortic valve repair rather than replacement for valve dysfunction, we assessed late outcomes of various repair techniques in the contemporary era. METHODS: From January 2001 to January 2011, aortic valve repair was planned in 1,124 patients. Techniques involved commissural figure-of-8 suspension sutures (n = 63 [6.2%]), cusp repair with commissuroplasty (n = 481 [48%]), debridement (n = 174 [17%]), free-margin plication (n = 271 [27%]) or resection (n = 75) or both, or annulus repair with resuspension (n = 230 [23%]), root reimplantation (n = 252 [25%]), or remodeling (n = 35 [3...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29240760/novel-linear-motif-filtering-protocol-reveals-the-role-of-the-lc8-dynein-light-chain-in-the-hippo-pathway
#13
Gábor Erdős, Tamás Szaniszló, Mátyás Pajkos, Borbála Hajdu-Soltész, Bence Kiss, Gábor Pál, László Nyitray, Zsuzsanna Dosztányi
Protein-protein interactions (PPIs) formed between short linear motifs and globular domains play important roles in many regulatory and signaling processes but are highly underrepresented in current protein-protein interaction databases. These types of interactions are usually characterized by a specific binding motif that captures the key amino acids shared among the interaction partners. However, the computational proteome-level identification of interaction partners based on the known motif is hindered by the huge number of randomly occurring matches from which biologically relevant motif hits need to be extracted...
December 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29225805/hospital-procedure-volume-does-not-predict-acute-kidney-injury-after-coronary-artery-bypass-grafting-a-nationwide-study
#14
Ankit Sakhuja, Kianoush Kashani, Jesse Schold, Wisit Cheungpasitporn, Edward Soltesz, Sevag Demirjian
Background: Acute kidney injury (AKI) is common after coronary artery bypass grafting (CABG) and is associated with poor outcome. Increased hospital procedure volume has been associated with better outcomes. However, the impact of hospital CABG volume on AKI needing dialysis (AKI-D) is less clear. We designed this study to examine (i) the impact of number of annual CABG procedures per hospital (CABG-vol) on AKI-D and inpatient mortality and (ii) if it modifies the relationship between AKI-D and mortality...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29217087/evolution-of-simplified-frozen-elephant-trunk-repair-for-acute-debakey-type-i-dissection-midterm-outcomes
#15
Eric E Roselli, Jay J Idrees, Faisal G Bakaeen, Michael Z Tong, Edward G Soltesz, Stephanie Mick, Douglas R Johnston, Mathew J Eagleton, Venu Menon, Lars G Svensson
BACKGROUND: A modified technique for frozen elephant trunk (FET) repair of acute DeBakey type I dissection has evolved. Procedural modifications are described and midterm outcomes evaluated. METHODS: From 2009 to 2016, 72 patients with DeBakey type I dissection underwent emergency simplified FET. Mean age was 59 ± 15 years. Presentation included malperfusion (n = 22, 31%), rupture (n = 12, 16%), and aortic insufficiency (n = 42, 58%). Concomitant procedures included valve replacement (n = 9), root replacement (n = 11; valve sparing n = 6), cusp repair (n = 11), and valve resuspension (n = 21)...
March 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29102214/the-atrial-fibrillation-prescription
#16
EDITORIAL
Marc Gillinov, Edward G Soltesz
No abstract text is available yet for this article.
January 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29089092/atrial-fibrillation-in-the-patient-undergoing-mitral-valve-surgery-a-once-in-a-lifetime-opportunity
#17
EDITORIAL
Marc Gillinov, Edward G Soltesz
No abstract text is available yet for this article.
March 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29080475/an-electrophysiological-investigation-of-reinforcement-effects-in-attention-deficit-hyperactivity-disorder-dissociating-cue-sensitivity-from-down-stream-effects-on-target-engagement-and-performance
#18
Georgia Chronaki, Fruzsina Soltesz, Nicholas Benikos, Edmund J S Sonuga-Barke
OBJECTIVE: Neural hypo-sensitivity to cues predicting positive reinforcement has been observed in ADHD using the Monetary Incentive Delay (MID) task. Here we report the first study using an electrophysiological analogue of this task to distinguish between (i) cue related anticipation of reinforcement and downstream effects on (ii) target engagement and (iii) performance in a clinical sample of adolescents with ADHD and controls. METHODS: Thirty-one controls and 32 adolescents with ADHD aged 10-16 years performed the electrophysiological (e)-MID task - in which preparatory cues signal whether a response to an upcoming target will be reinforced or not - under three conditions; positive reinforcement, negative reinforcement (response cost) and no consequence (neutral)...
December 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29050390/involvement-of-fast-spiking-cells-in-ictal-sequences-during-spontaneous-seizures-in-rats-with-chronic-temporal-lobe-epilepsy
#19
Adam R Neumann, Robrecht Raedt, Hendrik W Steenland, Mathieu Sprengers, Katarzyna Bzymek, Zaneta Navratilova, Lilia Mesina, Jeanne Xie, Valerie Lapointe, Fabian Kloosterman, Kristl Vonck, Paul A J M Boon, Ivan Soltesz, Bruce L McNaughton, Artur Luczak
See Lenck-Santini (doi:10.1093/awx205) for a scientific commentary on this article. Epileptic seizures represent altered neuronal network dynamics, but the temporal evolution and cellular substrates of the neuronal activity patterns associated with spontaneous seizures are not fully understood. We used simultaneous recordings from multiple neurons in the hippocampus and neocortex of rats with chronic temporal lobe epilepsy to demonstrate that subsets of cells discharge in a highly stereotypical sequential pattern during ictal events, and that these stereotypical patterns were reproducible across consecutive seizures...
September 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29031792/control-of-myogenic-tone-and-agonist-induced-contraction-of-intramural-coronary-resistance-arterioles-by-cannabinoid-type-1-receptors-and-endocannabinoids
#20
Mária Szekeres, György L Nádasy, Eszter Soltész-Katona, László Hunyady
It was tested whether intrinsic CB1 R activation modifies myogenic and agonist induced contraction of intramural coronary resistance arteries of the rat. CB1 R protein was detected by immuno-histochemistry and by Western blot, its mRNA by qRT-PCR in their wall. Microsurgically prepared cylindrical coronary segments (∼100-150μm) developed myogenic contraction (∼20% of relaxed luminal diameter), from which a substantial relaxation (∼15%) in response to WIN55212 (a specific agonist of the CB1 Rs) has been found...
January 2018: Prostaglandins & Other Lipid Mediators
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