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https://www.readbyqxmd.com/read/28316276/levosimendan-in-patients-with-left-ventricular-dysfunction-undergoing-cardiac-surgery
#1
Rajendra H Mehta, Jeffrey D Leimberger, Sean van Diepen, James Meza, Alice Wang, Rachael Jankowich, Robert W Harrison, Douglas Hay, Stephen Fremes, Andra Duncan, Edward G Soltesz, John Luber, Soon Park, Michael Argenziano, Edward Murphy, Randy Marcel, Dimitri Kalavrouziotis, Dave Nagpal, John Bozinovski, Wolfgang Toller, Matthias Heringlake, Shaun G Goodman, Jerrold H Levy, Robert A Harrington, Kevin J Anstrom, John H Alexander
Background Levosimendan is an inotropic agent that has been shown in small studies to prevent or treat the low cardiac output syndrome after cardiac surgery. Methods In a multicenter, randomized, placebo-controlled, phase 3 trial, we evaluated the efficacy and safety of levosimendan in patients with a left ventricular ejection fraction of 35% or less who were undergoing cardiac surgery with the use of cardiopulmonary bypass. Patients were randomly assigned to receive either intravenous levosimendan (at a dose of 0...
March 19, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28242017/the-left-atrial-appendage-a-surgical-target
#2
EDITORIAL
Edward Soltesz, Marc Gillinov
No abstract text is available yet for this article.
February 3, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28207437/lack-of-association-between-preoperative-statin-use-and-respiratory-and-neurologic-complications-after-cardiac-surgery
#3
Ryu Komatsu, Huseyin Oguz Yilmaz, Jing You, C Allen Bashour, Shobana Rajan, Edward G Soltesz, Daniel I Sessler, Alparslan Turan
BACKGROUND: Statins may reduce the risk of pulmonary and neurologic complications after cardiac surgery. METHODS: The authors acquired data for adults who had coronary artery bypass graft, valve surgery, or combined procedures. The authors matched patients who took statins preoperatively to patients who did not. First, the authors assessed the association between preoperative statin use and the primary outcomes of prolonged ventilation (more than 24 h), pneumonia (positive cultures of sputum, transtracheal fluid, bronchial washings, and/or clinical findings consistent with the diagnosis of pneumonia), and in-hospital all-cause mortality, using logistic regressions...
February 16, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28108567/role-of-the-frozen-elephant-trunk-procedure-for-chronic-aortic-dissection
#4
REVIEW
Eric E Roselli, Faisal G Bakaeen, Douglas R Johnston, Edward G Soltesz, Michael Z Tong
OBJECTIVES: Considering the chronic and progressive nature of aortic dissection, operative planning must anticipate the need for later interventions. We have increasingly used a modified version of the frozen elephant trunk repair operation to treat these patients. We review the indications, considerations for planning, and important operative details for performing frozen elephant trunk repair for chronic aortic dissection. METHODS: Frozen elephant trunk repair is performed using selective antegrade brain perfusion, direct placement of commercially available stent grafts with suture fixation in the aortic arch, and proximal aortic replacement...
January 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28043453/mechanical-vs-biologic-valves-our-modern-day-conundrum
#5
Thoralf M Sundt, Hartzell V Schaff, Edward G Soltesz, Miguel Sousa Uva, David H Adams
No abstract text is available yet for this article.
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28009257/interneuronal-mechanisms-of-hippocampal-theta-oscillations-in-a-full-scale-model-of-the-rodent-ca1-circuit
#6
Marianne J Bezaire, Ivan Raikov, Kelly Burk, Dhrumil Vyas, Ivan Soltesz
The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct interneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation...
December 23, 2016: ELife
https://www.readbyqxmd.com/read/27905022/neurophysiology-of-space-travel-energetic-solar-particles-cause-cell-type-specific-plasticity-of-neurotransmission
#7
Sang-Hun Lee, Barna Dudok, Vipan K Parihar, Kwang-Mook Jung, Miklós Zöldi, Young-Jin Kang, Mattia Maroso, Allyson L Alexander, Gregory A Nelson, Daniele Piomelli, István Katona, Charles L Limoli, Ivan Soltesz
In the not too distant future, humankind will embark on one of its greatest adventures, the travel to distant planets. However, deep space travel is associated with an inevitable exposure to radiation fields. Space-relevant doses of protons elicit persistent disruptions in cognition and neuronal structure. However, whether space-relevant irradiation alters neurotransmission is unknown. Within the hippocampus, a brain region crucial for cognition, perisomatic inhibitory control of pyramidal cells (PCs) is supplied by two distinct cell types, the cannabinoid type 1 receptor (CB1)-expressing basket cells (CB1BCs) and parvalbumin (PV)-expressing interneurons (PVINs)...
November 30, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27801844/screening-auxin-response-in-vitro-culture-aptitude-and-susceptibility-to-agrobacterium-mediated-transformation-of-italian-commercial-durum-wheat-varieties
#8
Wilma Sabetta, Cristina Crosatti, Alexandra Soltész, Valentina Di Rienzo, Cinzia Montemurro
The development of a robust Agrobacterium-mediated transformation protocol for a recalcitrant species like durum wheat requires the identification and optimization of factors affecting T-DNA delivery and plant regeneration. The purpose of this research was to compare the behavior of diverse durum wheat genotypes during in vitro culture and Agrobacterium tumefaciens-mediated transformation, using immature embryos as explants. Apart from plant genotype, two of the main influencing factors for a successful genetic transformation have been examined here, i...
October 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27788942/outcomes-of-a-less-invasive-approach-for-proximal-aortic-operations
#9
Melissa M Levack, Muhammad Aftab, Eric E Roselli, Douglas R Johnston, Edward G Soltesz, A Marc Gillinov, Gösta B Pettersson, Brian Griffin, Richard Grimm, Donald F Hammer, Adil H Al Kindi, Turki B Albacker, Edgardo Sepulveda, Lucy Thuita, Eugene H Blackstone, Joseph F Sabik, Lars G Svensson
BACKGROUND: Less-invasive techniques have previously been described for mitral and aortic valve operations; however, few studies have examined their benefit for aortic root and ascending aorta reconstruction. Using propensity matching, we compared outcomes of patients undergoing proximal aortic operations through a J incision compared with full sternotomy. METHODS: From January 1995 to January 2014, 8,533 patients underwent proximal aortic operations at Cleveland Clinic...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27767963/rheopheresis-in-vascular-diseases
#10
Vass Melinda, Diószegi Ágnes, Németh Norbert, Sógor Viktória, Baráth Sándor, Szalai Eszter, Módis László, Pál Soltész
Rheopheresis is an extracorporal selective double-filtration procedure. In the first part of the treatment the blood is passes through the plasma filter, which separates blood cells from the plasma. Then the plasma flow to a second filter called MONET (Membranefiltration Optimised Novel Extracorporal Treatment). The MONET filter retains high molecular weight proteins such LDL, Lp(a), fibrinogen, α2 macroglobulin, vWF and IgM. Hereby the whole blood and plasma viscosity decrease, improves microcirculation, and has a positive effect on lipid profile as well...
2016: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/27712829/thoracoabdominal-aortic-aneurysm-repair-big-case-big-risk-big-center
#11
Faisal G Bakaeen, Eric E Roselli, Douglas R Johnston, Edward G Soltesz, Michael Z Tong, Lars G Svensson
No abstract text is available yet for this article.
November 2016: Journal of Surgical Research
https://www.readbyqxmd.com/read/27576237/closed-loop-prevention-of-hypotension-in-the-heartbeating-brain-dead-porcine-model
#12
Kristian Soltesz, Christopher Sturk, Audrius Paskevicius, Qiuming Liao, Guangqi Qin, Trygve Sjoberg, Stig Steen
The purpose of this paper is to demonstrate feasibility of a novel closed-loop controlled therapy for prevention of hypertension in the heartbeating brain-dead porcine model. METHODS: Dynamic modeling and system identification were based on in vivo data. A robust controller design was obtained for the identified models. Disturbance attenuation properties, and reliability of operation of the resulting control system, were evaluated in vivo. RESULTS: The control system responded both predictably and consistently to external disturbances...
August 25, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27554237/etomidate-and-the-risk-of-complications-after-cardiac-surgery-a-retrospective-cohort-analysis
#13
Ryu Komatsu, Natalya Makarova, Jing You, Daniel I Sessler, David G Anthony, Yusuke Kasuya, Edward G Soltesz, Alparslan Turan
OBJECTIVE: To compare incidence of atrial arrhythmia, duration of care, and major complications after cardiac surgery between patients who received etomidate and those who received other induction agents. DESIGN: Retrospective cohort study utilizing propensity score matching. SETTING: A single academic, tertiary care hospital. PARTICIPANTS: Eight thousand nine hundred seventy-eight patients undergoing coronary artery bypass grafting (CABG), valve, or combined valve/CABG surgery requiring cardiopulmonary bypass between January 2005 and December 2010...
December 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27449353/outcomes-after-aortic-graft-to-graft-anastomosis-with-an-automated-circular-stapler-a-novel-approach
#14
Jay J Idrees, Farhang Yazdchi, Edward G Soltesz, Andrew M Vekstein, Christopher Rodriguez, Eric E Roselli
OBJECTIVE: Patients with complex aortic disease often require multistaged repairs with numerous anastomoses. Manual suturing can be time consuming. To reduce ischemic time, a circular stapling device has been used to facilitate prosthetic graft-to-graft anastomoses. Objectives are to describe this technique and assess outcomes. METHODS: From February 2009 to May 2014, 44 patients underwent complex aortic repair with a circular end-to-end anastomosis (EEA) stapler at Cleveland Clinic...
October 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27430050/-favourable-effects-of-kidney-transplantation-on-vascular-condition-of-patients-potential-prognostic-significance-of-non-invasive-measurement-of-arterial-stiffness
#15
Dávid Ágoston Kovács, László Asztalos, Renáta Laczik, Roland Fedor, László Szabó, Lajos Lőcsey, Pál Soltész
INTRODUCTION: Development of atherosclerosis is accelerated in kidney transplant patients. Impaired metabolic pathways have complex effect on the arterial wall which can be measured by non-invasive techniques. Only few data are available on the change of stiffness parameters in the postoperative course. Therefore, in this study the authors analysed the stiffness parameters of kidney transplant recipients during the perioperative period. AIM: Non-invasive clinical trial of the arterial functional parameters in the early postoperative period...
June 12, 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27335256/risk-factors-and-outcomes-of-patients-requiring-a-permanent-pacemaker-after-aortic-valve-replacement-in-the-united-states
#16
MULTICENTER STUDY
Michael P Robich, Nicholas K Schiltz, Douglas R Johnston, Stephanie Mick, Amar Krishnaswamy, Rodrigo A Iglesias, Dustin Hang, Eric E Roselli, Edward G Soltesz
INTRODUCTION: The need for permanent pacemaker implantation (PCM) following surgical aortic valve replacement (SAVR) is uncommon but can lead to increased hospital resource utilization. Using nationwide data, we sought to (1) identify hospital, patient, and procedure-level risk factors for PCM after SAVR and (2) determine incremental resource utilization. METHODS: We identified 659,692 patients from the Nationwide Inpatient Sample database who underwent SAVR with or without coronary artery bypass grafting (CABG), mitral valvuloplasty (MVr), or mitral valve replacement (MVR) between 1998 and 2009...
August 2016: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/27323941/organization-and-control-of-epileptic-circuits-in-temporal-lobe-epilepsy
#17
A Alexander, M Maroso, I Soltesz
When studying the pathological mechanisms of epilepsy, there are a seemingly endless number of approaches from the ultrastructural level-receptor expression by EM-to the behavioral level-comorbid depression in behaving animals. Epilepsy is characterized as a disorder of recurrent seizures, which are defined as "a transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain" (Fisher et al., 2005). Such abnormal activity typically does not occur in a single isolated neuron; rather, it results from pathological activity in large groups-or circuits-of neurons...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27194256/preclinical-safety-testing-for-morcellation-and-extraction-for-an-endobag-with-sealable-ports-in-vitro-pilot-study
#18
Michael Anapolski, Dimitrios Panayotopoulos, Ibrahim Alkatout, Stefan Soltesz, Sven Schiermeier, Günter Noé
BACKGROUND: Electromechanical power morcellation is an important tool of modern laparoscopy. Recent reports on the spread of previously undetected malignancy by power morcellation indicate the need for additional protective devices to reduce this risk. We conducted a study to obtain the first data concerning the safety of an endobag with three closable ports during morcellation and subsequent bag extraction under in vitro conditions, mimicking the settings in our operating theater. The second purpose of the study was to establish a minimal width of the skin incision necessary to safely extract the sealed bag after morcellation...
January 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27192613/power-morcellation-inside-a-secure-endobag-a-pilot-study
#19
Michael Anapolski, Dimitrios Panayotopoulos, Ibrahim Alkatout, Stefan Soltesz, Lieselotte Mettler, Sven Schiermeier, Wolfgang Hatzmann, Günter Noé
INTRODUCTION: Unprotected power morcellation can lead to a spread of previously undiagnosed malignancy. We present a new containment bag with two closable trocar insertion sites to reduce this risk. This pilot study was designed to assess the feasibility of this device under everyday conditions. MATERIAL AND METHODS: The containment bag was used in ten laparoscopic supracervical hysterectomies. We evaluated time requirement for bag insertion into the abdominal cavity and in-bag morcellation...
August 2016: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/26952291/outcomes-after-elective-proximal-aortic-replacement-a-matched-comparison-of-isolated%C3%A2-versus-multicomponent-operations
#20
COMPARATIVE STUDY
Jay J Idrees, Eric E Roselli, Ashley M Lowry, Joshua M Reside, Hoda Javadikasgari, Daniel J Johnson, Edward G Soltesz, Douglas R Johnston, Gösta B Pettersson, Eugene H Blackstone, Joseph F Sabik, Lars G Svensson
BACKGROUND: Guidelines supporting the decision to replace the aorta in patients with chronic asymptomatic proximal aortic disease are limited by lack of data on operative risks and long-term effectiveness in relation to aortic size. Therefore, we assessed and compared outcomes of patients undergoing elective isolated proximal aortic replacement for this disease vs replacement during multicomponent operations. METHODS: From January 2006 to January 2011, 1,889 patients underwent proximal aortic replacement (isolated, 212; multicomponent, 1,677) for chronic asymptomatic ascending and arch pathology...
June 2016: Annals of Thoracic Surgery
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