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https://www.readbyqxmd.com/read/28807719/maternal-hypothyroidism-an-overview-of-current-experimental-models
#1
REVIEW
Mahboubeh Ghanbari, Asghar Ghasemi
Maternal hypothyroidism (MH) is the most common cause of transient congenital hypothyroidism. Different animal models are used for assessing developmental effects of MH in offspring. The severity and status of hypothyroidism in animal models must be a reflection of the actual conditions in humans. To obtain comparable results with different clinical conditions, which lead to MH in humans, several factors have been suggested for researchers to consider before designing the experimental models. Regarding development of fetal body systems during pregnancy, interference at different times provides different results and the appropriate time for induction of hypothyroidism should be selected based on accurate time of development of the system under assessment...
August 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/28804518/comparative-frequency-of-four-different-types-of-pregnancy-associated-thyrotoxicosis-in-a-single-thyroid-centre
#2
Akane Ide, Nobuyuki Amino, Takumi Kudo, Waka Yoshioka, Mako Hisakado, Eijun Nishihara, Mitsuru Ito, Shuji Fukata, Hirotoshi Nakamura, Akira Miyauchi
BACKGROUND: Pregnancy and delivery markedly influence thyroid function. However, the comparative prevalence of gestational thyrotoxicosis (GT), new onset of Graves' disease during pregnancy (GD during pregnancy), postpartum destructive thyrotoxicosis (PPT), and postpartum Graves' thyrotoxicosis (PPGD) has not yet been determined. METHODS: We prospectively registered and performed a review of 4127 consecutive non treated female patients with thyrotoxicosis, seen between August 2008 and December 2013 in our outpatient clinic of Kuma Hospital...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28799552/thyroid-function-thyroid-hypofunction-in-pregnancy
#3
Claire Greenhill
No abstract text is available yet for this article.
August 11, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28799288/neuroprotective-activity-of-cannabinoid-receptor-2-against-oxidative-stress-and-apoptosis-in-rat-pups-having-experimentally-induced-congenital-hypothyroidism
#4
Mehmet Eray Alcigir, Halef Okan Dogan, Sevil Atalay Vural, Fatma Meriç Yilmaz
In this study, it was aimed to show the cannabinoid receptor-2 (CB2) role, which is a part of neuroprotective endocannabinoidal system, against increasing nitric oxide synthetase (iNOS, eNOS) levels and the apoptotic activity (caspase-3, caspase-9 and DNA in situ fragmentation) within the postnatal critical period in pups of pregnant rats with artificially induced maternal thyroid hormone (TH) deficiency. Each of the 3 groups established comprised 1 male and 2 female rats, and they were coupled. Their pups were used...
August 11, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28776582/thyroid-disease-in-pregnancy-new-insights-in-diagnosis-and-clinical-management
#5
REVIEW
Tim I M Korevaar, Marco Medici, Theo J Visser, Robin P Peeters
Adequate thyroid hormone availability is important for an uncomplicated pregnancy and optimal fetal growth and development. Overt thyroid disease is associated with a wide range of adverse obstetric and child development outcomes. An increasing number of studies now indicate that milder forms of thyroid dysfunction are also associated with these adverse pregnancy outcomes. The definitions of both overt and subclinical thyroid dysfunction have changed considerably over the past few years, as new data indicate that the commonly used fixed upper limits of 2...
August 4, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28771718/effect-of-follicular-diameter-at-the-time-of-ovulation-triggering-on-pregnancy-outcomes-during-intrauterine-insemination
#6
Mohammad A Maher, Ahmed Abdelaziz, Yasser A Shehata
OBJECTIVE: To compare pregnancy outcomes when triggering ovulation at different follicle sizes during intrauterine insemination (IUI) cycles. METHODS: A prospective observational study was undertaken at two collaborative fertility centers in Saudi Arabia between January 2014 and May 2016. Women of any age were enrolled if they met inclusion criteria: primary, secondary, or unexplained infertility (≥1 year); day-2 follicle-stimulating hormone less than 12 IU/mL; normal prolactin, thyroid function, and uterine cavity; at least one patent tube; and a male partner with normal semen count and motility...
August 3, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28770411/effect-of-iodine-nutrition-on-pregnancy-outcomes-in-an-iodine-sufficient-area-in-china
#7
Yue Xiao, Huakun Sun, Chenyan Li, Yongze Li, Shiqiao Peng, Chenling Fan, Weiping Teng, Zhongyan Shan
Many studies focused on the association between thyroid disease and pregnancy outcomes. The present study explored the effect of iodine nutrition during the first trimester on pregnancy outcomes. One thousand five hundred sixty-nine pregnant, euthyroid women at ≤12 weeks of gestation in an iodine-sufficient area in China were recruited. According to the World Health Organization (WHO) criteria for iodine nutrition during pregnancy, participants were divided into four groups: adequate iodine (median urinary iodine concentration (UIC), 150-249 μg/L), mild deficiency (UIC, 100-150 μg/L), moderate and severe deficiency (UIC, <100 μg/L), and more than adequate and excessive (UIC, ≥250 μg/L) groups...
August 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28758357/thyroid-medication-use-and-birth-defects-in-the-national-birth-defects-prevention-study
#8
Meredith M Howley, Sarah C Fisher, Alissa R Van Zutphen, Dorothy K Waller, Suzan L Carmichael, Marilyn L Browne
BACKGROUND: Thyroid disorders are common among reproductive-aged women, with hypothyroidism affecting 2 to 3% of pregnancies, and hyperthyroidism affecting an additional 0.1 to 1%. We examined associations between thyroid medications and individual birth defects using data from the National Birth Defects Prevention Study (NBDPS). METHODS: The NBDPS is a multisite, population-based, case-control study that included pregnancies with estimated delivery dates from 1997 to 2011...
July 31, 2017: Birth defects research
https://www.readbyqxmd.com/read/28755549/childhood-maltreatment-is-associated-with-increased-risk-of-subclinical-hypothyroidism-in-pregnancy
#9
Nora K Moog, Christine M Heim, Sonja Entringer, Norbert Kathmann, Pathik D Wadhwa, Claudia Buss
The critical importance of thyroid hormones for fetal development is well established. The developing fetus is dependent on the mother for adequate thyroid hormone supply, and maternal thyroid dysfunction in pregnancy may result in suboptimal fetal development. Because exposure to childhood maltreatment (CM) has been associated with thyroid dysfunction in the non-pregnant state, we sought to test the hypothesis that exposure to CM may represent a risk factor for the development of maternal hypothyroidism in pregnancy...
July 20, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28746798/thyroid-disease-symptoms-during-early-pregnancy-do-not-identify-women-with-thyroid-hypofunction-that-should-be-treated
#10
V J Pop, M A Broeren, W M Wiersinga, A Stagnaro-Green
OBJECTIVE: to evaluate whether women during early pregnancy with ''hypothyroidism'' symptoms are at risk for biochemical defined hypothyroidism. The 2017 guidelines of the American Thyroid Association (ATA) recommend case finding on the basis of symptoms to identify these women during pregnancy, while evidence is lacking. DESIGN: Construct validation of a thyroid hypofunction symptom checklist during first trimester of pregnancy comparing high scores with biochemical defined hypothyroidism...
July 26, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28727687/hippocampus-dependent-memory-and-allele-specific-gene-expression-in-adult-offspring-of-alcohol-consuming-dams-after-neonatal-treatment-with-thyroxin-or-metformin
#11
E Tunc-Ozcan, S L Wert, P H Lim, A Ferreira, E E Redei
Fetal alcohol spectrum disorder (FASD), the result of fetal alcohol exposure (FAE), affects 2-11% of children worldwide, with no effective treatments. Hippocampus-based learning and memory deficits are key symptoms of FASD. Our previous studies show hypothyroxinemia and hyperglycemia of the alcohol-consuming pregnant rat, which likely affects fetal neurodevelopment. We administered vehicle, thyroxine (T4) or metformin to neonatal rats post FAE and rats were tested in the hippocampus-dependent contextual fear-conditioning paradigm in adulthood...
July 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28726182/autoimmune-hypothyroidism-is-three-times-more-frequent-in-female-prolactinoma-patients-compared-to-healthy-women-data-from-a-cross-sectional-case-control-study
#12
Atanaska Elenkova, Iliana Аtanasova, Georgi Кirilov, Еmil Natchev, Ralitza Ivanova, Roussanka Кovatcheva, Silvia Vandeva, Dimitar Tcharaktchiev, Sabina Zacharieva
BACKGROUND: The potent immunomodulatory action of prolactin has been demonstrated in many experimental in vitro studies. In accordance with these data, our retrospective analyses revealed higher prevalence of autoimmune thyroid diseases in prolactinoma patients compared to general population. PURPOSE: A cross-sectional case-control study was carried out in a single tertiary referral centre. The main aim was to assess the frequency of newly diagnosed autoimmune thyroid diseases in female patients with prolactinomas...
July 19, 2017: Endocrine
https://www.readbyqxmd.com/read/28716942/maternal-photoperiod-programs-hypothalamic-thyroid-status-via-the-fetal-pituitary-gland
#13
Cristina Sáenz de Miera, Béatrice Bothorel, Catherine Jaeger, Valérie Simonneaux, David Hazlerigg
In wild mammals, offspring development must anticipate forthcoming metabolic demands and opportunities. Within species, different developmental strategies may be used, dependent on when in the year conception takes place. This phenotypic flexibility is initiated before birth and is linked to the pattern of day length (photoperiod) exposure experienced by the mother during pregnancy. This programming depends on transplacental communication via the pineal hormone melatonin. Here, we show that, in the Siberian hamster (Phodopus sungorus), the programming effect of melatonin is mediated by the pars tuberalis (PT) of the fetal pituitary gland, before the fetal circadian system and autonomous melatonin production is established...
August 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28716848/managing-thyroid-disease-in-women-planning-pregnancy
#14
Jennifer Yamamoto, Lois E Donovan
No abstract text is available yet for this article.
July 17, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28713532/bilateral-cavernous-sinus-thrombosis-as-first-manifestation-of-primary-burkitt-lymphoma-of-the-thyroid-gland
#15
Mehdi Moghaddasi, Mona Nabovvati, Saeed Razmeh
Cavernous sinus thrombosis (CST) is a rare condition that is usually associated with infections, pregnancy, vasculitis and some types of medication, such as the contraceptive pill and paraneoplastic. Primary Burkitt lymphoma (PBL) of the thyroid gland is very uncommon and the clinical description of such cases has been largely limited to case reports. In this paper, we present a case of CST as the first manifestation of PBL of the thyroid gland. To the best of our knowledge, our patient is the first case report of PBL of the thyroid gland that presents with bilateral CST...
June 23, 2017: Neurology International
https://www.readbyqxmd.com/read/28713331/thyroid-stimulating-hormone-receptor-antibodies-in-pregnancy-clinical-relevance
#16
REVIEW
Ines Bucci, Cesidio Giuliani, Giorgio Napolitano
Graves' disease is the most common cause of thyrotoxicosis in women of childbearing age. Approximately 1% of pregnant women been treated before, or are being treated during pregnancy for Graves' hyperthyroidism. In pregnancy, as in not pregnant state, thyroid-stimulating hormone (TSH) receptor (TSHR) antibodies (TRAbs) are the pathogenetic hallmark of Graves' disease. TRAbs are heterogeneous for molecular and functional properties and are subdivided into activating (TSAbs), blocking (TBAbs), or neutral (N-TRAbs) depending on their effect on TSHR...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28704192/risk-factors-for-postpartum-thyroid-dysfunction-in-euthyroid-women-prior-to-pregnancy
#17
Boyan I Nonchev, Antoaneta V Argatska, Blagovest K Pehlivanov, Maria M Orbetzova
BACKGROUND: Thyroid dysfunction is common during the postpartum and the predisposing factors for its development are considered specific for the population studied. The aim of this study was to evaluate the risk factors for the occurrence of postpartum thyroid dysfunction (PPTD) in euthyroid women prior to pregnancy. MATERIALS AND METHODS: Forty-five women with PPTD and 55 age-matched euthyroid postpartum women from Plovdiv, Bulgaria were included in the study. TSH, FT4, FT3, TPOAb, TgAb, TRAb were measured and ultrasound evaluation of the thyroid was performed in the first trimester of pregnancy and during the postpartum...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28690281/women-with-subclinical-hypothyroidism-are-at-low-risk-of-poor-pregnancy-outcome-in-japan
#18
Seishi Furukawa, Kazuko Miyakawa, Joichi Shibata, Mitsutoshi Iwashita
Maternal subclinical hypothyroidism may be associated with adverse pregnancy outcomes, although not consistently across regions. Here, we sought to determine the effect of elevated thyroid-stimulating hormone (TSH) on pregnancy outcomes in Japanese women without known medical complications. TSH was determined by dried blood spots at 8-20 weeks of gestation, and 3.0-10.0 μU/mL of TSH was considered as elevated TSH (eTSH). A retrospective study involving 167 cases of eTSH was conducted. Five hundred and seventy eight of controls with normal TSH and without thyroid antibodies were selected...
July 2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28689782/the-microbiota-and-autoimmunity-their-role-in-thyroid-autoimmune-diseases
#19
REVIEW
Hedda L Köhling, Sue F Plummer, Julian R Marchesi, Kelly S Davidge, Marian Ludgate
Since the 1970s, the role of infectious diseases in the pathogenesis of Graves' disease (GD) has been an object of intensive research. The last decade has witnessed many studies on Yersinia enterocolitica, Helicobacter pylori and other bacterial organisms and their potential impact on GD. Retrospective, prospective and molecular binding studies have been performed with contrary outcomes. Until now it is not clear whether bacterial infections can trigger autoimmune thyroid disease. Common risk factors for GD (gender, smoking, stress, and pregnancy) reveal profound changes in the bacterial communities of the gut compared to that of healthy controls but a pathogenetic link between GD and dysbiosis has not yet been fully elucidated...
July 6, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28672769/reference-intervals-and-longitudinal-changes-in-copeptin-and-mr-proadm-concentrations-during-pregnancy
#20
Annemiek M C P Joosen, Ivon J M van der Linden, Lianne Schrauwen, Alisia Theeuwes, Monique J M de Groot, Antonius A M Ermens
BACKGROUND: Vasopressin and adrenomedullin and their stable by-products copeptin and midregional part of proadrenomedullin (MR-proADM) are promising biomarkers for the development of preeclampsia. However, clinical use is hampered by the lack of trimester-specific reference intervals. We therefore estimated reference intervals for copeptin and MR-proADM in disease-free Dutch women throughout pregnancy. METHODS: Apparently healthy low risk pregnant women were recruited...
June 16, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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