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https://www.readbyqxmd.com/read/28724186/inositol-hexaphosphate-insp6-as-an-effective-topical-treatment-for-patients-receiving-adjuvant-chemotherapy-after-breast-surgery
#1
S Proietti, V Pasta, A Cucina, C Aragona, E Palombi, I Vucenik, M Bizzarri
OBJECTIVE: Oral treatment with inositol hexaphosphate (InsP6) has shown to be efficient in decreasing adverse effects in patients with breast cancer under chemotherapy. This study was aimed at evaluating and comparing the efficacy of topical InsP6 in improving quality of life in women treated with anticancer drugs. PATIENTS AND METHODS: The study was a double-blind, randomized controlled trial (RCT) with allocation concealment of 20 patients in two groups, one (experimental) applied 4% topical formulation of InsP6 once a day, whereas the second one (control) a gel containing hyaluronic acid...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28714091/habitual-diet-and-diet-quality-in-irritable-bowel-syndrome-a%C3%A2-case-control-study
#2
E F Tigchelaar, Z Mujagic, A Zhernakova, M A M Hesselink, S Meijboom, C W M Perenboom, A A M Masclee, C Wijmenga, E J M Feskens, D M A E Jonkers
BACKGROUND: Diet is considered to be a key factor in symptom generation in Irritable Bowel Syndrome (IBS) and patients tend to exclude food products from their diet in pursue of symptom relief, which may impair diet quality. METHODS: We evaluated habitual dietary intake in IBS patients with regard to nutrients and food products using an extensive food frequency questionnaire. One hundred ninety-four IBS patients were compared to 186 healthy controls using multiple logistic regression analysis...
July 17, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28709930/particle-image-velocimetry-study-of-the-celiac-trunk-hemodynamic-induced-by-continuous-flow-left-ventricular-assist-device
#3
Francesco Scardulla, Diego Bellavia, Leonardo D'Acquisto, Giuseppe M Raffa, Salvatore Pasta
Whereas left ventricular assist device (LVAD) is the gold-standard therapy for patients with heart failure, gastrointestinal bleeding is one of the most common complications. LVAD implantation may remarkably impact aortic hemodynamics so that experimental and computational flow analyses can be used to study the disease mechanisms. Here we present an experimentally-calibrated computational model of the celiac trunk hemodynamic of a LVAD-supported patient who experienced bleeding after device implantation. Specifically, both particle image velocimetry (PIV) and echocardiography were used to measure and compare flow distributions in each branch of a phantom model of the patient abdominal aorta...
July 12, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28709315/heat-perturbation-spreading-in-the-fermi-pasta-ulam-%C3%AE-system-with-next-nearest-neighbor-coupling-competition-between-phonon-dispersion-and-nonlinearity
#4
Daxing Xiong
We employ the heat perturbation correlation function to study thermal transport in the one-dimensional Fermi-Pasta-Ulam-β lattice with both nearest-neighbor and next-nearest-neighbor couplings. We find that such a system bears a peculiar phonon dispersion relation, and thus there exists a competition between phonon dispersion and nonlinearity that can strongly affect the heat correlation function's shape and scaling property. Specifically, for small and large anharmoncities, the scaling laws are ballistic and superdiffusive types, respectively, which are in good agreement with the recent theoretical predictions; whereas in the intermediate range of the nonlinearity, we observe an unusual multiscaling property characterized by a nonmonotonic delocalization process of the central peak of the heat correlation function...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28709247/intermittent-many-body-dynamics-at-equilibrium
#5
C Danieli, D K Campbell, S Flach
The equilibrium value of an observable defines a manifold in the phase space of an ergodic and equipartitioned many-body system. A typical trajectory pierces that manifold infinitely often as time goes to infinity. We use these piercings to measure both the relaxation time of the lowest frequency eigenmode of the Fermi-Pasta-Ulam chain, as well as the fluctuations of the subsequent dynamics in equilibrium. The dynamics in equilibrium is characterized by a power-law distribution of excursion times far off equilibrium, with diverging variance...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28707281/towards-a-comprehensive-conceptual-framework-of-active-travel-behavior-a-review-and-synthesis-of-published-frameworks
#6
REVIEW
Thomas Götschi, Audrey de Nazelle, Christian Brand, Regine Gerike
PURPOSE OF REVIEW: This paper reviews the use of conceptual frameworks in research on active travel, such as walking and cycling. Generic framework features and a wide range of contents are identified and synthesized into a comprehensive framework of active travel behavior, as part of the Physical Activity through Sustainable Transport Approaches project (PASTA). PASTA is a European multinational, interdisciplinary research project on active travel and health. RECENT FINDINGS: Along with an exponential growth in active travel research, a growing number of conceptual frameworks has been published since the early 2000s...
July 13, 2017: Current Environmental Health Reports
https://www.readbyqxmd.com/read/28681347/new-concepts-on-the-clinical-course-and-stratification-of-compensated-and-decompensated-cirrhosis
#7
REVIEW
Gennaro D'Amico, Alberto Morabito, Mario D'Amico, Linda Pasta, Giuseppe Malizia, Paola Rebora, Maria Grazia Valsecchi
The clinical course of cirrhosis has been typically described by a compensated and a decompensated state based on the absence or, respectively, the presence of any of bleeding, ascites, encephalopathy or jaundice. More recently, it has been recognized that increasing portal hypertension and several major clinical events are followed by a marked worsening in prognosis, and disease states have been proposed accordingly in a multistate model. The development of multistate models implies the assessment of the probabilities of more than one possible outcome from each disease state...
July 5, 2017: Hepatology International
https://www.readbyqxmd.com/read/28672067/comparison-of-fev1-reference-equations-for-evaluating-a-cystic-fibrosis-therapeutic-intervention
#8
Michael W Konstan, Jeffrey S Wagener, Donald R VanDevanter, David J Pasta, Stefanie J Millar, Wayne J Morgan
OBJECTIVES: The Global Lung Function Initiative (GLI, 2012) developed reference equations for forced expiratory volume in 1 s (FEV1 ). Previous equations were developed by groups led by Knudson (1983), Wang (1993), Hankinson (1999), and Stanojevic (2008).(1,2,4,6) We assessed how different prediction equations affect the conclusions from a therapeutic intervention study that evaluated the rate of percent predicted FEV1 (ppFEV1 ) decline. METHODOLOGY: Using data from the Epidemiologic Study of cystic fibrosis (CF), we re-analyzed our previous study evaluating the relationship of dornase alfa (DA) use with ppFEV1 using the Knudson, Wang & Hankinson, Stanojevic, and GLI equations...
July 3, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28664551/the-impact-of-voluntary-targets-on-the-sodium-content-of-processed-foods-in-brazil-2011-2013
#9
Eduardo A F Nilson, Ana M Spaniol, Vivian S S Gonçalves, Michele L Oliveira, Norm Campbell, Mary L'Abbé, Patricia C Jaime
Brazilians consume excessive dietary sodium (4700 mg/d); hence, the reduction of dietary sodium intake has been a Brazilian government priority. A set of strategies has been implemented that includes food and nutrition education initiatives and the reduction in the sodium content of processed foods and foods consumed out of the households. Since 2011, the Ministry of Health has selected priority food categories that contribute to over 90% of sodium intake from processed foods and have set biannual voluntary targets for sodium reduction with food industries to encourage food reformulation...
June 29, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28656971/dietary-patterns-cost-and-compliance-with-low-protein-diet-of-phenylketonuria-and-other-inherited-metabolic-diseases
#10
T Mlčoch, R Puda, P Ješina, M Lhotáková, Š Štěrbová, T Doležal
BACKGROUND/OBJECTIVES: Phenylketonuria (PKU) and several other inherited metabolic diseases (IMD) require a lifelong low-protein diet (LPD), otherwise they lead to many health complications. LPDs, however, carry a significant economic burden for patients and their families. The objective of this study was to explore the costs of low-protein foods (LPFs) necessary for LPD as well as dietary patterns and compliance towards an LPD. SUBJECTS/METHODS: A detailed questionnaire was created in cooperation with National Association of PKU and other IMD (NSPKU), and consequently sent to all NSPKU members treated with an LPD (n=303)...
June 28, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28655506/in-silico-shear-and-intramural-stresses-are-linked-to-aortic-valve-morphology-in-dilated-ascending-aorta
#11
S Pasta, G Gentile, G M Raffa, D Bellavia, G Chiarello, R Liotta, A Luca, C Scardulla, M Pilato
OBJECTIVE/BACKGROUND: The development of ascending aortic dilatation in patients with bicuspid aortic valve (BAV) is highly variable, and this makes surgical decision strategies particularly challenging. The purpose of this study was to identify new predictors, other than the well established aortic size, that may help to stratify the risk of aortic dilatation in BAV patients. METHODS: Using fluid-structure interaction analysis, both haemodynamic and structural parameters exerted on the ascending aortic wall of patients with either BAV (n = 21) or tricuspid aortic valve (TAV; n = 13) with comparable age and aortic diameter (42...
June 24, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28654921/effect-of-maternal-dietary-patterns-during-pregnancy-on-self-reported-allergic-diseases-in-the-first-3-years-of-life-results-from-the-gusto-study
#12
Evelyn Xiu Ling Loo, Lynn Ong, Anne Goh, Ai-Ru Chia, Oon Hoe Teoh, Marjorelee T Colega, Yiong Huak Chan, Seang Mei Saw, Kenneth Kwek, Peter D Gluckman, Keith M Godfrey, Hugo Van Bever, Bee Wah Lee, Yap Seng Chong, Mary Foong-Fong Chong, Lynette Pei-Chi Shek
BACKGROUND: Maternal diet during pregnancy has been suggested to be an important early-life exposure that influences immune tolerance and the development of allergic diseases in offspring. METHODS: We examined the relationship between maternal dietary patterns assessed using 24-h recalls and food diaries at 26-28 weeks of pregnancy and the subsequent development of allergic outcomes in the offspring in the Growing Up in Singapore towards Healthy Outcomes (GUSTO) birth cohort...
June 28, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28651551/consumer-attitudes-and-misperceptions-associated-with-trends-in-self-reported-cereal-foods-consumption-cross-sectional-study-of-western-australian-adults-1995-to-2012
#13
Christina Mary Pollard, Claire Elizabeth Pulker, Xingqiong Meng, Jane Anne Scott, Felicity Claire Denham, Vicky Anne Solah, Deborah Anne Kerr
BACKGROUND: The reasons for low adherence to cereal dietary guidelines are not well understood but may be related to knowledge, attitudes, beliefs and perceived barriers. This study aims to assess trends in cereal foods consumption, intention to change and factors associated with intake among Western Australian (WA) adults 18 to 64 years. METHOD: Cross-sectional data from the 1995, 1998, 2001, 2004, 2009, and 2012 Nutrition Monitoring Survey Series involving 7044 adults were pooled...
June 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28635340/from-seed-to-cooked-pasta-influence-of-traditional-and-non-conventional-transformation-processes-on-total-antioxidant-capacity-and-phenolic-acid-content
#14
Daniela Martini, Roberto Ciccoritti, Isabella Nicoletti, Francesca Nocente, Danilo Corradini, Maria Grazia D'Egidio, Federica Taddei
The aim of this work was to compare the traditional with a non-conventional (i.e. kernel micronisation) durum wheat milling process by monitoring the content of bound, conjugated and free phenolic acids (PAs) and the level of the total antioxidant capacity (TAC) occurring in the durum wheat pasta production chain, from seed to cooked pasta. The traditional transformation processes negatively influenced TAC and PA content (40% and 89% decrease from seed to cooked pasta, respectively), mainly during the milling process (25% and 84% decrease of TAC and PA, respectively), which has been related to the removal of external layers of kernels...
June 21, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/28626589/the-effects-of-food-labelling-on-postexercise-energy-intake-in-sedentary-women
#15
Jacynthe Lafrenière, Jessica McNeil, Véronique Provencher, Éric Doucet
Food labelling has been previously reported to influence energy intake (EI). Whether food labels influence postexercise EI remains to be determined. We assessed how food labelling and exercise (Ex) interact to influence food perception and postexercise EI. In this randomized crossover design, 14 inactive women participated in 4 experimental conditions: Ex (300 kcal at 70% of VO2peak) and lunch labelled as low in fat (LF), Ex and lunch labelled as high in fat (HF), Rest and LF, and Rest and HF. The lunch was composed of a plate of pasta, yogurt, and oatmeal cookies, which had the same nutritional composition across the 4 experimental conditions...
2017: Journal of Obesity
https://www.readbyqxmd.com/read/28617084/patients-with-cystic-fibrosis-and-a-g551d-or-homozygous-f508del-mutation-similar-lung-function-decline
#16
Gregory S Sawicki, Edward F McKone, Stefanie J Millar, David J Pasta, Michael W Konstan, Barry Lubarsky, Jeffrey S Wagener
No abstract text is available yet for this article.
June 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28602133/nutritional-and-environmental-factors-in-attention-deficit-hyperactivity-disorder-adhd-a-cross-sectional-study
#17
Ismael San Mauro Martín, Javier Andrés Blumenfeld Olivares, Elena Garicano Vilar, Manuela Echeverry López, Marta García Bernat, Yaiza Quevedo Santos, Marta Blanco López, Paloma Elortegui Pascual, Elena Borregon Rivilla, Mario Rincón Barrado
OBJECTIVES: Attention-deficit hyperactivity disorder (ADHD) has been related to nutrient deficiencies and 'unhealthy' diets, and to date there is only one study that examined the relationship between the Mediterranean diet and ADHD. The aim was to determine the association between those environmental, nutritional, and body composition factors that may affect the pathogenesis and symptomatology of patients with ADHD in Spain. METHODS: A total of 89 children and adolescents (41 with diagnosed ADHD and 48 controls) were studied in an observation case-control study...
June 11, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28582480/pastaspark-multiple-sequence-alignment-meets-big-data
#18
José M Abuín, Tomás F Pena, Juan C Pichel
Motivation: One basic step in many bioinformatics analyses is the Multiple Sequence Alignment (MSA). One of the state of the art tools to performMSA is PASTA (Practical Alignments using SATé and TrAnsitivity). PASTA supportsmultithreading but it is limited to process datasets on shared memory systems. In this work we introduce PASTASpark, a tool that uses the Big Data engine Apache Spark to boost the performance of the alignment phase of PASTA, which is the most expensive task in terms of time consumption...
June 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28578068/phenolic-profile-and-fermentation-patterns-of-different-commercial-gluten-free-pasta-during-in-vitro-large-intestine-fermentation
#19
Gabriele Rocchetti, Luigi Lucini, Giulia Chiodelli, Gianluca Giuberti, Antonio Gallo, Francesco Masoero, Marco Trevisan
The fate of phenolic compounds, along with short-chain fatty acids (SCFAs) production kinetics, was evaluated on six different commercial gluten-free (GF) pasta samples varying in ingredient compositions, focussing on the in vitro faecal fermentation after the gastrointestinal digestion. A general reduction of both total phenolics and reducing power was observed in all samples, together with a substantial change in phenolic profile over 24h of faecal fermentation, with differences among GF pasta samples. Flavonoids, hydroxycinnamics and lignans degraded over time, with a concurrent increase in low-molecular-weight phenolic acids (hydroxybenzoic acids), alkylphenols, hydroxybenzoketones and tyrosols...
July 2017: Food Research International
https://www.readbyqxmd.com/read/28562673/analysis-of-parb-centromere-interactions-by-multiplex-spr-imaging-reveals-specific-patterns-for-binding-parb-in-six-centromeres-of-burkholderiales-chromosomes-and-plasmids
#20
Flavien Pillet, Fanny Marie Passot, Franck Pasta, Véronique Anton Leberre, Jean-Yves Bouet
Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales...
2017: PloS One
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